%0 Generic %A Post, Christina %A Boule, Lisbeth A. %A Burke, Catherine %A O'Dell, Colleen %A Winans, Bethany %A Paige Lawrence, B. %D 2019 %T IFNg FCS files to support Figs 3 & 4 in "The ancestral environment shapes antiviral CD8+ T cell responses across generations" %U https://nih.figshare.com/articles/dataset/IFNg_FCS_files_to_support_Figs_3_4_in_The_ancestral_environment_shapes_antiviral_CD8_T_cell_responses_across_generations_/9696308 %R 10.35092/yhjc.9696308.v1 %2 https://nih.figshare.com/ndownloader/files/17372615 %2 https://nih.figshare.com/ndownloader/files/17372618 %2 https://nih.figshare.com/ndownloader/files/17372621 %2 https://nih.figshare.com/ndownloader/files/17372627 %2 https://nih.figshare.com/ndownloader/files/17372636 %2 https://nih.figshare.com/ndownloader/files/17372633 %2 https://nih.figshare.com/ndownloader/files/17372624 %2 https://nih.figshare.com/ndownloader/files/17372630 %2 https://nih.figshare.com/ndownloader/files/17372639 %2 https://nih.figshare.com/ndownloader/files/17372642 %2 https://nih.figshare.com/ndownloader/files/17372645 %2 https://nih.figshare.com/ndownloader/files/17372648 %2 https://nih.figshare.com/ndownloader/files/17372651 %2 https://nih.figshare.com/ndownloader/files/17372654 %2 https://nih.figshare.com/ndownloader/files/17372657 %2 https://nih.figshare.com/ndownloader/files/17372660 %2 https://nih.figshare.com/ndownloader/files/17372669 %2 https://nih.figshare.com/ndownloader/files/17372672 %2 https://nih.figshare.com/ndownloader/files/17372666 %2 https://nih.figshare.com/ndownloader/files/17372675 %2 https://nih.figshare.com/ndownloader/files/17372678 %2 https://nih.figshare.com/ndownloader/files/17372681 %2 https://nih.figshare.com/ndownloader/files/17372687 %2 https://nih.figshare.com/ndownloader/files/17372684 %2 https://nih.figshare.com/ndownloader/files/17372690 %2 https://nih.figshare.com/ndownloader/files/17372693 %2 https://nih.figshare.com/ndownloader/files/17372696 %2 https://nih.figshare.com/ndownloader/files/17372699 %2 https://nih.figshare.com/ndownloader/files/17372705 %2 https://nih.figshare.com/ndownloader/files/17372708 %2 https://nih.figshare.com/ndownloader/files/17372702 %2 https://nih.figshare.com/ndownloader/files/17372714 %2 https://nih.figshare.com/ndownloader/files/17372711 %2 https://nih.figshare.com/ndownloader/files/17372723 %2 https://nih.figshare.com/ndownloader/files/17372717 %2 https://nih.figshare.com/ndownloader/files/17372720 %2 https://nih.figshare.com/ndownloader/files/17372726 %2 https://nih.figshare.com/ndownloader/files/17372729 %K aryl hydrocarbon receptor %K transgenerational exposure %K influenza virus %X

Figure 3: F0 exposure to TCDD has developmental, but not transgenerational effects on the CD8+ T response to IAV in the lung of male TCDD lineage offspring


7-8 male mice from each treatment group were infected with IAV and the CD8+ T cell response in the lung was measured 8 days later.


(I) The flow plot depicts the mean percent of IFNg+CD8+ T cells in the lung of F1 offspring. (J) The mean number of IFNg+CD8+ T cells in the lung of F1 offspring. (K) The flow plots show the mean percent of IFNg+CD8+ T cells in the lung of F3 offspring. (L) The mean number of IFNg+CD8+ T cells in the lung of F3 offspring.


Figure 4: In the MLN, F0 AHR activation alters the CD8+ T cell response of female and male F1 but not F3 generation offspring. F1 and F3 generation offspring were generated as shown in Fig 1A. 7-9 adult F1 and F3 generation offspring from each treatment group were infected with IAV and MLN cells were harvested on day 8 (males) or 9 (females) post infection. The graphs depict the mean number of cells from vehicle and TCDD offspring found in the MLN on day 8 or 9 post IAV infection.


(C) The number of IFNg+CD8+ T cells in female F1 (left) and F3 (right) offspring.

(G) The number of IFNg+CD8+ T cells in male F1 (left) and F3 (right) generation offspring.
%I The NIH Figshare Archive