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Dataset from Mouse 4 for Sit & Goard: Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex
datasetposted on 12.06.2020 by Kevin Sit, Michael Goard
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Accompanying dataset for Sit KK, Goard MJ. Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex.
This dataset contains the data for mouse 4 / 10
See all data in collection here: https://doi.org/10.35092/yhjc.c.5018363
These datasets contain calcium imaging data taken from L2/3 of the primary visual cortex in mice. Mice were head fixed and passively watching a random dot kinematogram stimulus. The stimulus data vector for processing these data are also included. The accompanying code to analyze these data can be found at: https://github.com/kevinksit/CoherentMotionProject
Data are either in preprocessed DFF matrices, which represent the change in neural activity compared to a baseline or raw images from the microscope. All data are processed with MATLAB 2018b.
The purpose of these data is to understand the organization of neural activity in response to coherent motion in the murine visual cortex.
The manuscript associated with these data is Sit KK, Goard MJ. Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex.
Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific visual cortical regions are specialized for processing of coherent visual motion. However, whether mouse visual cortex has a similar organization remains unclear, despite powerful genetic tools available for measuring population neural activity. Here, we use widefield and 2-photon calcium imaging of transgenic mice to measure mesoscale and cellular responses to coherent motion. Imaging of primary visual cortex (V1) and higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) reveals varied responsiveness to coherent motion, with stronger responses in dorsal stream areas compared to ventral stream areas. Moreover, there is considerable anisotropy within visual areas, such that neurons representing the lower visual field are more responsive to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed heterogeneously both across and within visual areas.
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- MH - National Institute of Mental Health (NIMH)