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Two-photon Dataset from All Mice for Sit & Goard: Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex

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posted on 12.06.2020 by Kevin Sit, Michael Goard
Accompanying dataset for Sit KK, Goard MJ. Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex.

This dataset contains all the two-photon recordings in L2/3 V1 for all mice used.

See related data in collection here: https://doi.org/10.35092/yhjc.c.5018363

The purpose of these data is to understand the organization of neural activity in response to coherent motion in the murine visual cortex.

The manuscript associated with these data is Sit KK, Goard MJ. Distributed and Retinotopically Asymmetric Processing of Coherent Motion in Mouse Visual Cortex.

ABSTRACT
Perception of visual motion is important for a range of ethological behaviors in mammals. In primates, specific visual cortical regions are specialized for processing of coherent visual motion. However, whether mouse visual cortex has a similar organization remains unclear, despite powerful genetic tools available for measuring population neural activity. Here, we use widefield and 2-photon calcium imaging of transgenic mice to measure mesoscale and cellular responses to coherent motion. Imaging of primary visual cortex (V1) and higher visual areas (HVAs) during presentation of natural movies and random dot kinematograms (RDKs) reveals varied responsiveness to coherent motion, with stronger responses in dorsal stream areas compared to ventral stream areas. Moreover, there is considerable anisotropy within visual areas, such that neurons representing the lower visual field are more responsive to coherent motion. These results indicate that processing of visual motion in mouse cortex is distributed heterogeneously both across and within visual areas.

Funding

Dissection of the neural circuitry of short-term memory in behaving mice

National Institute of Mental Health

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NeuroNex Technology Hub: Nemonic: Next generation multiphoton neuroimaging consortium

Directorate for Biological Sciences

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Hillblom Foundation

Whitehall Foundation

History

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  • MH - National Institute of Mental Health (NIMH)

Is this associated with a publication?

No

I confirm there is no human identifiable information in this dataset.

Yes

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