Variant key	seen in RNA (1=Yes,0=No)	ID	tumor type	1000genome all freq	dbSNP_ID	Cosmic Info	CGC Tier	Gene Name	All Transcripts AAchange for 25mer	Transcript Info	transcript ID	Mutation type	Exon	cDNA change	AA change	Wt Epitope	Mut Epitope	Gene Expression Decile for this sample(1=lowest expression-10=highest expression)	Exome VAF Decile	Screening Status	Comments	key	mmp status
14:45513866-45513866 G>T	0.0	4335	COLORECTAL	-	-	-	-	FAM179B	uc001wvv.3,p.R1316L|NM_015091,p.R1316L|ENST00000361577,p.R1316L|uc001wvw.3,p.R1316L|ENST00000361462,p.R1316L	retained_intron, protein_coding, nonsense_mediated_decay	uc001wvw.3	nonsynonymous SNV	exon13	c.G3947T	p.R1316L	VQEVKNLRSGVSRAAVVCLSDLFTY	VQEVKNLRSGVSLAAVVCLSDLFTY	8.0	4.0	-	-	4335_14:45513866-45513866 G>T_VQEVKNLRSGVSLAAVVCLSDLFTY	0.0
1:6680026-6680026 A>T	1.0	4196	COLORECTAL	-	-	-	-	PHF13	NM_153812,p.K102M|uc001aob.4,p.K102M|ENST00000377648,p.K102M	protein_coding, processed_transcript	uc001aob.4	nonsynonymous SNV	exon3	c.A305T	p.K102M	FSHLQPTLLQRAKPSNFLLDRKKTD	FSHLQPTLLQRAMPSNFLLDRKKTD	6.0	5.0	-	-	4196_1:6680026-6680026 A>T_FSHLQPTLLQRAMPSNFLLDRKKTD	0.0
7:132192270-132192270 T>A	0.0	4298	COLORECTAL	-	-	-	-	PLXNA4	uc003vra.4,p.S395C|ENST00000378539,p.S395C|ENST00000359827,p.S395C|uc003vrb.3,p.S395C|NM_181775,p.S395C|uc003vrc.2,p.S395C|NM_001105543,p.S395C|NM_020911,p.S395C|ENST00000321063,p.S395C|ENST00000423507,p.S395C	retained_intron, protein_coding	uc003vrc.2	nonsynonymous SNV	exon2	c.A1183T	p.S395C	LAWLKVKDIPCSSALLTIDDNFCGL	LAWLKVKDIPCSCALLTIDDNFCGL	5.0	4.0	-	-	4298_7:132192270-132192270 T>A_LAWLKVKDIPCSCALLTIDDNFCGL	0.0
7:117431919-117431919 C>T	1.0	4346	COLORECTAL	-	-	ID=COSM1548059;OCCURENCE=1(lung)	-	CTTNBP2	ENST00000160373,p.R444Q|NM_033427,p.R444Q|uc003vjf.3,p.R444Q|ENST00000441556,p.R444Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vjf.3	nonsynonymous SNV	exon4	c.G1331A	p.R444Q	CANTSLHPGLNPRIQAARFRFQGNA	CANTSLHPGLNPQIQAARFRFQGNA	5.0	9.0	-	-	4346_7:117431919-117431919 C>T_CANTSLHPGLNPQIQAARFRFQGNA	0.0
16:11935835-11935835 C>T	1.0	4335	COLORECTAL	-	-	-	-	RSL1D1	uc010buv.1,p.G220R|uc002dbp.1,p.G220R|NM_015659,p.G220R	retained_intron, protein_coding, nonsense_mediated_decay	uc010buv.1	nonsynonymous SNV	exon6	c.G658A	p.G220R	SGSCSAIRIGHVGMQIEHIIENIVA	SGSCSAIRIGHVRMQIEHIIENIVA	10.0	7.0	CD8	-	4335_16:11935835-11935835 C>T_SGSCSAIRIGHVRMQIEHIIENIVA	1.0
12:123818611-123818611 A>G	1.0	2591	MELANOMA	-	-	-	-	SBNO1	ENST00000420886,p.Y300H|uc001uet.2,p.Y300H|ENST00000267176,p.Y299H|ENST00000602398,p.Y300H|uc001uev.2,p.Y298H|uc010tao.2,p.Y299H|uc009zxy.1,p.Y265H|NM_001167856,p.Y300H|uc010tap.2,p.Y300H|uc001ueu.2,p.Y299H|ENST00000602750,p.Y299H|NM_018183,p.Y299H	protein_coding	uc010tap.2	nonsynonymous SNV	exon6	c.T898C	p.Y300H	GWLSALQLEAITYAAQQHETFLPNG	GWLSALQLEAITHAAQQHETFLPNG	6.0	3.0	-	-	2591_12:123818611-123818611 A>G_GWLSALQLEAITHAAQQHETFLPNG	0.0
1:29435945-29435945 C>T	1.0	3879	MELANOMA	-	-	-	-	EPB41	uc001brl.2,p.T771I|uc001brg.2,p.T581I|NM_203342,p.T581I|ENST00000356093,p.T771I|uc001bri.2,p.T715I|uc021okg.1,p.T750I|ENST00000347529,p.T715I|ENST00000373798,p.T804I|uc001brm.2,p.T804I|ENST00000349460,p.T581I|ENST00000343067,p.T804I|uc009vtm.2,p.T383I|NM_001166007,p.T541I|uc001brj.2,p.T541I|ENST00000398863,p.T707I|NM_203343,p.T715I|NM_001166005,p.T804I|uc009vtl.2,p.T498I	protein_coding, processed_transcript	uc021okg.1	nonsynonymous SNV	exon14	c.C2249T	p.T750I	SETPSSTTTTQITKTVKGGISETRI	SETPSSTTTTQIIKTVKGGISETRI	7.0	3.0	-	-	3879_1:29435945-29435945 C>T_SETPSSTTTTQIIKTVKGGISETRI	0.0
4:47938625-47938625 C>T	0.0	3903	MELANOMA	-	-	-	-	CNGA1	ENST00000402813,p.R698Q|ENST00000358519,p.R629Q|NM_000087,p.R629Q|uc003gxu.3,p.R698Q|ENST00000420489,p.R629Q|NM_001142564,p.R698Q|uc003gxt.4,p.R629Q|ENST00000514170,p.R629Q|ENST00000544810,p.R629Q	retained_intron, protein_coding	uc003gxu.3	nonsynonymous SNV	exon10	c.G2093A	p.R698Q	GSDPKDLEEKVTRMEGSVDLLQTRF	GSDPKDLEEKVTQMEGSVDLLQTRF	2.0	8.0	-	-	3903_4:47938625-47938625 C>T_GSDPKDLEEKVTQMEGSVDLLQTRF	0.0
11:118771477-118771477 G>A	1.0	3466	MELANOMA	-	-	-	1	BCL9L	ENST00000334801,p.P992L|uc001pug.3,p.P992L|NM_182557,p.P992L|uc009zal.3,p.P987L	protein_coding, processed_transcript	uc009zal.3	nonsynonymous SNV	exon6	c.C2960T	p.P987L	GSSLSVRSPTGSPSRLKSPSMAVPS	GSSLSVRSPTGSLSRLKSPSMAVPS	7.0	4.0	-	-	3466_11:118771477-118771477 G>A_GSSLSVRSPTGSLSRLKSPSMAVPS	0.0
21:47776997-47776997 C>T	1.0	3713	MELANOMA	-	-	-	-	PCNT	NM_006031,p.S682L|uc002zji.4,p.S682L|uc002zjj.3,p.S564L|ENST00000359568,p.S682L	retained_intron, protein_coding, processed_transcript	uc002zjj.3	nonsynonymous SNV	exon13	c.C1691T	p.S564L	VLGLETEHKVQLSLLQTELKEEIEL	VLGLETEHKVQLLLLQTELKEEIEL	8.0	2.0	-	-	3713_21:47776997-47776997 C>T_VLGLETEHKVQLLLLQTELKEEIEL	0.0
1:170521499-170521499 C>T	1.0	3713	MELANOMA	-	-	ID=COSM677209;OCCURENCE=1(lung)	-	GORAB	uc009wvx.2,p.P181S|ENST00000367763,p.P361S|uc001ghb.2,p.P181S|uc001ghd.2,p.P154S|NM_152281,p.P361S|uc001ghc.2,p.P181S|uc001gha.2,p.P361S	protein_coding, processed_transcript	uc009wvx.2	nonsynonymous SNV	exon5	c.C541T	p.P181S	KENRKCQEQAVSPKVDDQCGNSSSI	KENRKCQEQAVSSKVDDQCGNSSSI	7.0	9.0	-	-	3713_1:170521499-170521499 C>T_KENRKCQEQAVSSKVDDQCGNSSSI	0.0
14:39771344-39771344 A>T	1.0	4234	NSCLC	-	-	-	-	CTAGE5	ENST00000603904,p.E240D|uc001wvg.4,p.E269D|NM_203355,p.E269D|uc001wvj.4,p.E240D|uc010tqe.1,p.E231D|uc001wvf.4,p.E194D|ENST00000553352,p.E240D|uc001wva.4,p.E240D|NM_005930,p.E269D|NM_001247988,p.E240D|uc001wuy.4,p.E189D|ENST00000396158,p.E274D|NM_001247990,p.E194D|NM_203354,p.E257D|ENST00000280083,p.E269D|ENST00000557038,p.E189D|uc001wvh.4,p.E269D|NM_001247989,p.E274D|ENST00000556148,p.E194D|NM_203356,p.E240D|ENST00000341749,p.E257D|uc001wvb.4,p.E240D|ENST00000553728,p.E804D|ENST00000348007,p.E269D|ENST00000341502,p.E269D|uc001wuz.4,p.E257D|uc001wvc.4,p.E214D|uc001wvi.4,p.E274D|ENST00000396165,p.E240D|uc001wve.1,p.E245D	 processed_transcript,protein_coding	uc010tqe.1	nonsynonymous SNV	exon9	c.A693T	p.E231D	LNDKESHIKTLTERLLKMKDWAAML	LNDKESHIKTLTDRLLKMKDWAAML	9.0	10.0	-	-	4234_14:39771344-39771344 A>T_LNDKESHIKTLTDRLLKMKDWAAML	0.0
2:179499194-179499194 T>A	0.0	4298	COLORECTAL	-	-	-	-	TTN	ENST00000342992,p.K11537M|NM_003319,p.K5040M|ENST00000589042,p.K14105M|uc021vtb.2,p.K5040M|NM_133437,p.K5232M|uc021vsy.2,p.K11537M|ENST00000460472,p.K5040M|uc021vsz.2,p.K5232M|NM_133432,p.K5165M|NM_001256850,p.K12464M|uc031rqc.1,p.K14105M|ENST00000359218,p.K5165M|uc021vta.2,p.K5165M|NM_001267550,p.K14105M|ENST00000591111,p.K12464M|ENST00000342175,p.K5232M|uc031rqd.1,p.K12464M|NM_133378,p.K11537M	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon180	c.A37391T	p.K12464M	KSSDKFDIIADGKKHILVINDSQFD	KSSDKFDIIADGMKHILVINDSQFD	7.0	6.0	-	-	4298_2:179499194-179499194 T>A_KSSDKFDIIADGMKHILVINDSQFD	0.0
19:46319206-46319206 T>G	1.0	4345	COLORECTAL	-	-	-	-	SYMPK	uc002pdn.3,p.E1197A|ENST00000245934,p.E1197A|NM_004819,p.E1197A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002pdn.3	nonsynonymous SNV	exon26	c.A3590C	p.E1197A	SEEAMDFREEGPECETPGIFISMDD	SEEAMDFREEGPACETPGIFISMDD	9.0	4.0	-	-	4345_19:46319206-46319206 T>G_SEEAMDFREEGPACETPGIFISMDD	0.0
2:189910536-189910536 C>G	0.0	4186	BREAST	-	-	-	-	COL5A2	NM_000393,p.R1100T|uc002uqk.3,p.R1100T|ENST00000374866,p.R1100T|uc010frx.3,p.R676T	retained_intron, protein_coding	uc010frx.3	nonsynonymous SNV	exon30	c.G2027C	p.R676T	PGPVGAPGDAGQRGDPGSRGPIGPP	PGPVGAPGDAGQTGDPGSRGPIGPP	7.0	4.0	-	-	4186_2:189910536-189910536 C>G_PGPVGAPGDAGQTGDPGSRGPIGPP	0.0
1:157805798-157805798 C>A	0.0	4245	COLORECTAL	-	-	-	-	CD5L	NM_005894,p.G68V|uc001frk.4,p.G68V|ENST00000368174,p.G68V	protein_coding, processed_transcript	uc001frk.4	nonsynonymous SNV	exon3	c.G203T	p.G68V	KDVAVLCRELGCGAASGTPSGILYE	KDVAVLCRELGCVAASGTPSGILYE	2.0	5.0	-	-	4245_1:157805798-157805798 C>A_KDVAVLCRELGCVAASGTPSGILYE	0.0
11:20869220-20869220 C>T	0.0	4278	COLORECTAL	-	-	ID=COSM213828;OCCURENCE=1(breast)	-	NELL1	NM_201551,p.R143C|uc001mqf.3,p.R143C|uc009yid.3,p.R171C|NM_006157,p.R143C|NM_001288713,p.R171C|uc001mqe.3,p.R143C|ENST00000532434,p.R143C|ENST00000298925,p.R171C|ENST00000357134,p.R143C	retained_intron, protein_coding, processed_transcript	uc009yid.3	nonsynonymous SNV	exon5	c.C511T	p.R171C	HNGKPRTEALPYRMADGQWHKVALS	HNGKPRTEALPYCMADGQWHKVALS	5.0	10.0	-	-	4278_11:20869220-20869220 C>T_HNGKPRTEALPYCMADGQWHKVALS	0.0
8:28651392-28651392 G>T	1.0	4245	COLORECTAL	-	-	-	-	INTS9	NM_018250,p.S323R|ENST00000523303,p.S323R|ENST00000521777,p.S299R|uc011lav.2,p.S299R|uc003xha.3,p.S323R|NM_001172562,p.S299R|uc011lax.2,p.S216R|NM_001145159,p.S302R|ENST00000521022,p.S323R|uc011law.2,p.S302R|ENST00000397363,p.S217R|ENST00000523436,p.S278R|ENST00000416984,p.S302R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lax.2	nonsynonymous SNV	exon8	c.C648A	p.S216R	CLYQYIDSAGLSSVPLYFISPVANS	CLYQYIDSAGLSRVPLYFISPVANS	8.0	5.0	-	-	4245_8:28651392-28651392 G>T_CLYQYIDSAGLSRVPLYFISPVANS	0.0
6:71004099-71004099 G>A	1.0	2369	MELANOMA	-	-	-	-	COL9A1	ENST00000370496,p.S156L|uc003pfg.4,p.S156L|NM_001851,p.S156L|ENST00000357250,p.S156L	retained_intron, protein_coding, processed_transcript	uc003pfg.4	nonsynonymous SNV	exon5	c.C467T	p.S156L	IKINGQTQSVVFSYKGLDGSLQTAA	IKINGQTQSVVFLYKGLDGSLQTAA	7.0	9.0	-	-	2369_6:71004099-71004099 G>A_IKINGQTQSVVFLYKGLDGSLQTAA	0.0
9:132620855-132620855 C>T	1.0	4129	NSCLC	-	-	-	-	USP20	uc004bys.3,p.S103F|ENST00000315480,p.S103F|NM_006676,p.S103F|NM_001008563,p.S103F|uc004byr.3,p.S103F|uc004byt.2,p.S103F|ENST00000358355,p.S103F|NM_001110303,p.S103F|ENST00000372429,p.S103F	protein_coding, processed_transcript	uc004byt.2	nonsynonymous SNV	exon6	c.C308T	p.S103F	FLEQRLAAPLLGSSSKFSEQDSPPP	FLEQRLAAPLLGFSSKFSEQDSPPP	7.0	10.0	-	-	4129_9:132620855-132620855 C>T_FLEQRLAAPLLGFSSKFSEQDSPPP	0.0
14:31833417-31833417 ->A	0.0	4278	COLORECTAL	-	-	-	-	HEATR5A	ENST00000404677,p.L683fs|NM_015473,p.L683fs|ENST00000389961,p.L677fs|uc010tpk.1,p.L683fs|ENST00000543095,p.L683fs|uc001wrf.4,p.L683fs|ENST00000439727,p.L390fs|uc001wrg.1,p.L272fs|ENST00000439348,p.L677fs|uc010ami.3,p.L288fs	retained_intron, protein_coding	uc010tpk.1	frameshift insertion	exon16	c.2048dupT	p.L683fs	VVYRQRLYELLILLPPETYEGNLCA	VVYRQRLYELLIFITS	9.0	9.0	-	-	4278_14:31833417-31833417 ->A_VVYRQRLYELLIFITS	0.0
7:150839595-150839595 C>T	1.0	2556	MELANOMA	-	-	-	-	AGAP3	uc003wjg.1,p.S716F|ENST00000463381,p.S385F|NM_031946,p.S716F|uc003wjj.1,p.S215F|NM_001281300,p.S385F|uc003wje.1,p.S385F|uc003wjk.1,p.S134F|ENST00000397238,p.S716F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003wjk.1	nonsynonymous SNV	exon3	c.C401T	p.S134F	HRHLGAHLSRVRSLDLDDWPPELLA	HRHLGAHLSRVRFLDLDDWPPELLA	9.0	1.0	-	-	2556_7:150839595-150839595 C>T_HRHLGAHLSRVRFLDLDDWPPELLA	0.0
11:78380497-78380497 C>T	0.0	4259	COLORECTAL	-	-	-	-	TENM4	ENST00000278550,p.R2298Q|uc001ozl.4,p.R2298Q|NM_001098816,p.R2298Q|ENST00000530738,p.R762Q|uc001ozk.4,p.R523Q	retained_intron, protein_coding, processed_transcript	uc001ozl.4	nonsynonymous SNV	exon32	c.G6893A	p.R2298Q	SWSVRYRYDGLGRRVSSKSSHSHHL	SWSVRYRYDGLGQRVSSKSSHSHHL	4.0	6.0	-	-	4259_11:78380497-78380497 C>T_SWSVRYRYDGLGQRVSSKSSHSHHL	0.0
1:242042461-242042461 C>A	1.0	4189	MELANOMA	-	-	-	-	EXO1	NM_130398,p.S642Y|NM_003686,p.S642Y|uc009xgq.3,p.S641Y|ENST00000348581,p.S642Y|ENST00000518483,p.S642Y|ENST00000366548,p.S642Y|uc021plj.1,p.S642Y|uc001hzh.3,p.S642Y|NM_006027,p.S642Y|uc021plk.1,p.S642Y	protein_coding, processed_transcript	uc021plk.1	nonsynonymous SNV	exon11	c.C1925A	p.S642Y	LQQFRRKSDSPTSLPENNMSDVSQL	LQQFRRKSDSPTYLPENNMSDVSQL	8.0	1.0	-	-	4189_1:242042461-242042461 C>A_LQQFRRKSDSPTYLPENNMSDVSQL	0.0
8:117778974-117778974 G>T	1.0	4126	NSCLC	-	-	-	-	UTP23	ENST00000517814,p.Q44H|ENST00000521703,p.Q44H|ENST00000357148,p.Q44H|ENST00000309822,p.Q44H|uc003yoc.3,p.Q44H|ENST00000517820,p.Q44H|NM_032334,p.Q44H|ENST00000521071,p.Q44H	retained_intron, protein_coding, nonsense_mediated_decay	uc003yoc.3	nonsynonymous SNV	exon1	c.G132T	p.Q44H	GTFCQAALRGRIQLREQLPRYLMGE	GTFCQAALRGRIHLREQLPRYLMGE	9.0	6.0	CD8	-	4126_8:117778974-117778974 G>T_GTFCQAALRGRIHLREQLPRYLMGE	1.0
5:82833434-82833434 G>C	0.0	3775	CERVICAL	-	-	-	-	VCAN	ENST00000343200,p.E551Q|NM_001164097,p.E551Q|uc003kil.3,p.E202Q|uc003kii.3,p.E1538Q|ENST00000513960,p.E551Q|NM_004385,p.E1538Q|uc003kij.3,p.E551Q|ENST00000265077,p.E1538Q	retained_intron, protein_coding, processed_transcript	uc003kil.3	nonsynonymous SNV	exon1	c.G604C	p.E202Q	DTEVGHQAHEHTEPVSLFPEESSGE	DTEVGHQAHEHTQPVSLFPEESSGE	10.0	8.0	-	-	3775_5:82833434-82833434 G>C_DTEVGHQAHEHTQPVSLFPEESSGE	0.0
15:69739230-69739230 G>T	1.0	4196	COLORECTAL	-	-	-	-	KIF23	uc010bii.3,p.M745I|ENST00000260363,p.M939I|ENST00000559279,p.M835I|uc002asc.3,p.M835I|NM_004856,p.M835I|ENST00000558585,p.M652I|ENST00000537891,p.M652I|NM_001281301,p.M745I|uc002asb.3,p.M939I|ENST00000352331,p.M835I|uc010ukc.2,p.M652I|NM_138555,p.M939I|ENST00000395392,p.M931I	retained_intron, protein_coding, nonsense_mediated_decay	uc010ukc.2	nonsynonymous SNV	exon17	c.G1956T	p.M652I	TDVETRCSVAVEMRAGSQLGPGYQH	TDVETRCSVAVEIRAGSQLGPGYQH	9.0	3.0	-	-	4196_15:69739230-69739230 G>T_TDVETRCSVAVEIRAGSQLGPGYQH	0.0
13:99092429-99092429 C>G	1.0	4301	MELANOMA	-	-	-	-	FARP1	ENST00000319562,p.L857V|ENST00000595437,p.L888V|NM_005766,p.L857V|uc001vnj.3,p.L857V|uc001vnh.3,p.L888V|ENST00000376586,p.L888V|NM_001286839,p.L888V	retained_intron, protein_coding, processed_transcript	uc001vnj.3	nonsynonymous SNV	exon23	c.C2569G	p.L857V	EKWVEDIQMAIDLAEKSSSPAPEFL	EKWVEDIQMAIDVAEKSSSPAPEFL	9.0	5.0	-	-	4301_13:99092429-99092429 C>G_EKWVEDIQMAIDVAEKSSSPAPEFL	0.0
X:38033598-38033598 G>A	1.0	3713	MELANOMA	-	-	-	-	SRPX	NM_001170751,p.P55L|uc011mkh.2,p.P55L|ENST00000538295,p.P55L|ENST00000378533,p.P55L|NM_006307,p.P55L|uc004ddy.2,p.P55L|NM_001170752,p.P55L|ENST00000432886,p.P55L|uc011mki.2,p.P55L	protein_coding, processed_transcript	uc011mki.2	nonsynonymous SNV	exon3	c.C164T	p.P55L	EVGYSHPRYKDTPWCSPIKVKYGDV	EVGYSHPRYKDTLWCSPIKVKYGDV	10.0	10.0	CD8	-	3713_X:38033598-38033598 G>A_EVGYSHPRYKDTLWCSPIKVKYGDV	1.0
1:155451059-155451059 C>T	1.0	3903	MELANOMA	-	-	-	-	ASH1L	ENST00000392403,p.M534I|NM_018489,p.M534I|uc009wqr.1,p.M534I|ENST00000368346,p.M534I|uc001fkt.3,p.M534I|uc009wqq.3,p.M534I	retained_intron, protein_coding, nonsense_mediated_decay	uc009wqr.1	nonsynonymous SNV	exon4	c.G1602A	p.M534I	QPPVYCTSPDFKMGGASDVSTAKSP	QPPVYCTSPDFKIGGASDVSTAKSP	7.0	1.0	-	-	3903_1:155451059-155451059 C>T_QPPVYCTSPDFKIGGASDVSTAKSP	0.0
4:141543786-141543786 C>T	1.0	4000	MELANOMA	-	-	-	-	TBC1D9	NM_015130,p.E1122K|uc010ioj.3,p.E1122K|ENST00000442267,p.E1122K	retained_intron, protein_coding	uc010ioj.3	nonsynonymous SNV	exon21	c.G3364A	p.E1122K	VEPLPASLAPDSEEHSLGGQMEDIK	VEPLPASLAPDSKEHSLGGQMEDIK	8.0	3.0	-	-	4000_4:141543786-141543786 C>T_VEPLPASLAPDSKEHSLGGQMEDIK	0.0
8:144620290-144620290 G>A	1.0	3466	MELANOMA	-	-	-	-	ZC3H3	NM_015117,p.S416L|ENST00000262577,p.S416L|uc003yyd.2,p.S416L	protein_coding	uc003yyd.2	nonsynonymous SNV	exon2	c.C1247T	p.S416L	ASQLSPVLSRSPSGDRPAVGHSGLK	ASQLSPVLSRSPLGDRPAVGHSGLK	5.0	7.0	-	-	3466_8:144620290-144620290 G>A_ASQLSPVLSRSPLGDRPAVGHSGLK	0.0
3:145791123-145791123 T>A	1.0	2369	MELANOMA	-	-	-	-	PLOD2	uc003evq.1,p.Y225F|uc003evr.1,p.Y565F|ENST00000461497,p.Y225F|ENST00000494950,p.Y510F|ENST00000360060,p.Y544F|NM_000935,p.Y544F|uc003evs.1,p.Y544F|ENST00000282903,p.Y565F|NM_182943,p.Y565F|uc011bnm.1,p.Y510F	retained_intron, protein_coding, nonsense_mediated_decay	uc011bnm.1	nonsynonymous SNV	exon16	c.A1529T	p.Y510F	QIFENPVDWKEKYINRDYSKIFTEN	QIFENPVDWKEKFINRDYSKIFTEN	6.0	2.0	-	-	2369_3:145791123-145791123 T>A_QIFENPVDWKEKFINRDYSKIFTEN	0.0
9:5763492-5763492 G>T	1.0	4245	COLORECTAL	-	-	ID=COSM1109396;OCCURENCE=1(endometrium)	-	RIC1	ENST00000414202,p.R822I|ENST00000251879,p.R822I|ENST00000418622,p.R743I|uc003zjj.1,p.R285I|uc003zjl.4,p.R785I|NM_020829,p.R822I|uc003zjh.4,p.R822I|ENST00000381532,p.R743I|NM_001206557,p.R785I|uc003zji.4,p.R822I|NM_001135920,p.R822I|ENST00000449720,p.R706I	retained_intron, protein_coding, nonsense_mediated_decay	uc003zjl.4	nonsynonymous SNV	exon18	c.G2354T	p.R785I	QLEVLFPFCVVERTSQIYLHHILRQ	QLEVLFPFCVVEITSQIYLHHILRQ	6.0	9.0	-	-	4245_9:5763492-5763492 G>T_QLEVLFPFCVVEITSQIYLHHILRQ	0.0
3:74350924-74350924 C>T	0.0	4326	BREAST	-	-	-	-	CNTN3	NM_020872,p.D607N|uc003dpm.1,p.D607N|ENST00000263665,p.D607N	protein_coding, processed_transcript	uc003dpm.1	nonsynonymous SNV	exon14	c.G1819A	p.D607N	RGSPGPPENVKVDEITDTTAQLSWK	RGSPGPPENVKVNEITDTTAQLSWK	4.0	10.0	-	-	4326_3:74350924-74350924 C>T_RGSPGPPENVKVNEITDTTAQLSWK	0.0
X:30577674-30577674 C>A	0.0	4266	COLORECTAL	-	-	-	-	CXorf21	NM_025159,p.A267S|uc004dcg.2,p.A267S|uc022bui.1,p.A267S|ENST00000378962,p.A267S	protein_coding	uc022bui.1	nonsynonymous SNV	exon1	c.G799T	p.A267S	QVSREKNLETSKARDIVFSRLLQLM	QVSREKNLETSKSRDIVFSRLLQLM	2.0	8.0	-	-	4266_X:30577674-30577674 C>A_QVSREKNLETSKSRDIVFSRLLQLM	0.0
19:43097789-43097789 G>A	0.0	4213	COLORECTAL	0.0009	-	-	-	CEACAM8	ENST00000244336,p.R110W|NM_001816,p.R110W|uc002oud.2,p.R110W	protein_coding	uc002oud.2	nonsynonymous SNV	exon2	c.C328T	p.R110W	RETIYPNASLLMRNVTRNDTGSYTL	RETIYPNASLLMWNVTRNDTGSYTL	4.0	7.0	-	-	4213_19:43097789-43097789 G>A_RETIYPNASLLMWNVTRNDTGSYTL	0.0
7:18875201-18875201 C>A	0.0	4287	COLORECTAL	-	-	-	-	HDAC9	NM_058176,p.P857T|NM_178425,p.P860T|ENST00000432645,p.P857T|ENST00000401921,p.P816T|uc003sue.3,p.P857T|ENST00000441542,p.P860T|ENST00000406451,p.P857T|uc003suh.3,p.P857T|uc003suj.3,p.P816T|uc003suk.3,p.P105T|NM_178423,p.P857T|uc003sui.3,p.P860T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003suk.3	nonsynonymous SNV	exon4	c.C313A	p.P105T	YDEGNFFPGSGAPNEVGTGLGEGYN	YDEGNFFPGSGATNEVGTGLGEGYN	6.0	10.0	-	-	4287_7:18875201-18875201 C>A_YDEGNFFPGSGATNEVGTGLGEGYN	0.0
15:101120911-101120911 G>A	1.0	3903	MELANOMA	-	-	ID=COSM1719370;OCCURENCE=2(NS)	-	LINS	ENST00000561308,p.S46F|ENST00000559577,p.S46F|NM_001040616,p.S46F|ENST00000560272,p.S46F|uc002bwi.3,p.S46F|ENST00000559736,p.S46F|uc002bwg.3,p.S46F|ENST00000560934,p.S46F|ENST00000314742,p.S46F	retained_intron, protein_coding, processed_transcript	uc002bwi.3	nonsynonymous SNV	exon2	c.C137T	p.S46F	PAVSDQDCSTATSLEWANTCGIQGR	PAVSDQDCSTATFLEWANTCGIQGR	8.0	4.0	-	-	3903_15:101120911-101120911 G>A_PAVSDQDCSTATFLEWANTCGIQGR	0.0
17:48243435-48243435 G>A	0.0	4316	COLORECTAL	-	-	-	-	SGCA	ENST00000262018,p.V12M|uc002iqi.3,p.V12M|NM_001135697,p.V12M|NM_000023,p.V12M|ENST00000344627,p.V12M|ENST00000502555,p.V12M|uc002iqj.3,p.V12M|ENST00000543315,p.V12M|ENST00000513821,p.V12M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002iqj.3	nonsynonymous SNV	exon1	c.G34A	p.V12M	MAETLFWTPLLVVLLAGLGDTEAQ	MAETLFWTPLLMVLLAGLGDTEAQ	2.0	7.0	-	-	4316_17:48243435-48243435 G>A_MAETLFWTPLLMVLLAGLGDTEAQ	0.0
2:166231326-166231326 T>A	0.0	4329	COLORECTAL	-	-	-	-	SCN2A	NM_001040143,p.N1368K|NM_001040142,p.N1368K|ENST00000375437,p.N1368K|ENST00000357398,p.N1368K|ENST00000375427,p.N1368K|ENST00000283256,p.N1368K|uc002udc.3,p.N1368K|NM_021007,p.N1368K|uc002udd.3,p.N1368K|uc002ude.3,p.N1368K	retained_intron, protein_coding	uc002ude.3	nonsynonymous SNV	exon21	c.T4104A	p.N1368K	VNLFAGKFYHCINYTTGEMFDVSVV	VNLFAGKFYHCIKYTTGEMFDVSVV	2.0	4.0	-	-	4329_2:166231326-166231326 T>A_VNLFAGKFYHCIKYTTGEMFDVSVV	0.0
1:894319-894319 G>A	1.0	4298	COLORECTAL	-	-	-	-	NOC2L	ENST00000327044,p.P57S|NM_015658,p.P57S|uc001abz.4,p.P57S|uc009vjq.3,p.P57S	retained_intron, protein_coding, processed_transcript	uc009vjq.3	nonsynonymous SNV	exon2	c.C169T	p.P57S	EAARSPDKPGGSPSASRRKGRASEH	EAARSPDKPGGSSSASRRKGRASEH	10.0	4.0	-	-	4298_1:894319-894319 G>A_EAARSPDKPGGSSSASRRKGRASEH	0.0
6:32037930-32037930 C>A	0.0	4252	COLORECTAL	-	-	-	-	TNXB	NM_019105,p.G1751V|ENST00000375244,p.G1751V|uc003nzl.2,p.G1751V|ENST00000375247,p.G1751V	retained_intron, protein_coding	uc003nzl.2	nonsynonymous SNV	exon14	c.G5252T	p.G1751V	FLLYGLLGKKRHGPLTADGTTEARS	FLLYGLLGKKRHVPLTADGTTEARS	7.0	10.0	-	-	4252_6:32037930-32037930 C>A_FLLYGLLGKKRHVPLTADGTTEARS	0.0
8:86171755-86171755 G>C	1.0	4252	COLORECTAL	-	-	-	-	CA13	uc003ydg.2,p.S114T|ENST00000321764,p.S114T|NM_198584,p.S114T	retained_intron, protein_coding, processed_transcript	uc003ydg.2	nonsynonymous SNV	exon3	c.G341C	p.S114T	DDHGSEHIVDGVSYAAELHVVHWNS	DDHGSEHIVDGVTYAAELHVVHWNS	7.0	9.0	-	-	4252_8:86171755-86171755 G>C_DDHGSEHIVDGVTYAAELHVVHWNS	0.0
18:58038632-58038632 G>C	1.0	4301	MELANOMA	-	-	-	-	MC4R	NM_005912,p.I317M|ENST00000299766,p.I317M|uc002lie.1,p.I317M	protein_coding	uc002lie.1	nonsynonymous SNV	exon1	c.C951G	p.I317M	RSQELRKTFKEIICCYPLGGLCDLS	RSQELRKTFKEIMCCYPLGGLCDLS	4.0	5.0	-	-	4301_18:58038632-58038632 G>C_RSQELRKTFKEIMCCYPLGGLCDLS	0.0
1:181453086-181453086 T>A	0.0	4326	BREAST	-	-	-	-	CACNA1E	uc009wxt.3,p.L69Q|ENST00000360108,p.L69Q|NM_001205293,p.L69Q|ENST00000357570,p.L20Q|uc009wxs.3,p.L69Q|ENST00000358338,p.L20Q|NM_001205294,p.L69Q|ENST00000524607,p.L69Q|ENST00000367573,p.L69Q|ENST00000367570,p.L69Q|uc001gow.3,p.L69Q|NM_000721,p.L69Q|ENST00000526775,p.L69Q	retained_intron, protein_coding	uc009wxt.3	nonsynonymous SNV	exon1	c.T206A	p.L69Q	PVRQNCFTVNRSLFIFGEDNIVRKY	PVRQNCFTVNRSQFIFGEDNIVRKY	3.0	8.0	-	-	4326_1:181453086-181453086 T>A_PVRQNCFTVNRSQFIFGEDNIVRKY	0.0
8:144776275-144776275 C>T	0.0	3713	MELANOMA	-	-	-	-	ZNF707	ENST00000532205,p.P231S|ENST00000532158,p.P231S|uc003yze.4,p.P231S|uc003yzh.4,p.P158S|NM_001288805,p.P231S|ENST00000454097,p.P231S|ENST00000358656,p.P231S|uc010mfh.3,p.P231S|NM_173831,p.P231S|NM_001100598,p.P231S|NM_001100599,p.P231S|ENST00000418203,p.P231S|NM_001288806,p.P231S|NM_001288808,p.P195S|NM_001288809,p.P195S|uc010mfi.3,p.P231S|uc003yzf.4,p.P231S|NM_001288807,p.P158S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010mfi.3	nonsynonymous SNV	exon5	c.C691T	p.P231S	LQRHQKNHTREKPFCCEACGQAFSL	LQRHQKNHTREKSFCCEACGQAFSL	4.0	3.0	-	-	3713_8:144776275-144776275 C>T_LQRHQKNHTREKSFCCEACGQAFSL	0.0
11:77850619-77850619 T>C	1.0	4252	COLORECTAL	-	-	-	-	ALG8	NM_024079,p.I6V|uc001oza.1,p.I6V|NM_001007027,p.I6V|uc001oyz.1,p.I6V|ENST00000530454,p.I6V|ENST00000299626,p.I6V|ENST00000376156,p.I6V|ENST00000532050,p.I6V|ENST00000526737,p.I6V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001oza.1	nonsynonymous SNV	exon1	c.A16G	p.I6V	MAALTIATGTGNWFSALA	MAALTVATGTGNWFSALA	10.0	7.0	-	-	4252_11:77850619-77850619 T>C_MAALTVATGTGNWFSALA	0.0
14:24619999-24619999 C>T	0.0	4238	COLORECTAL	0.0005	-	-	-	RNF31	ENST00000559275,p.R313C|uc001wml.1,p.R313C|uc010alg.1,p.R279C|NM_017999,p.R464C|uc001wmn.1,p.R464C|ENST00000382687,p.R313C|ENST00000324103,p.R464C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010alg.1	nonsynonymous SNV	exon7	c.C835T	p.R279C	LEKGPPKPGPPRRLSAPLPSSCGDP	LEKGPPKPGPPRCLSAPLPSSCGDP	10.0	9.0	-	-	4238_14:24619999-24619999 C>T_LEKGPPKPGPPRCLSAPLPSSCGDP	0.0
13:114774921-114774921 T>A	1.0	4284	COLORECTAL	-	-	-	-	RASA3	ENST00000334062,p.Y537F|uc001vuj.3,p.Y154F|ENST00000389544,p.Y505F|uc010tkk.2,p.Y505F|NM_007368,p.Y537F|uc001vui.3,p.Y537F	protein_coding	uc010tkk.2	nonsynonymous SNV	exon17	c.A1514T	p.Y505F	LSKSKSASFKESYMATFYEFFNEQK	LSKSKSASFKESFMATFYEFFNEQK	8.0	4.0	-	-	4284_13:114774921-114774921 T>A_LSKSKSASFKESFMATFYEFFNEQK	0.0
7:47897291-47897291 G>C	0.0	4316	COLORECTAL	-	-	-	-	PKD1L1	uc003tny.2,p.A1501G|NM_138295,p.A1501G|ENST00000289672,p.A1501G	retained_intron, protein_coding, processed_transcript	uc003tny.2	nonsynonymous SNV	exon28	c.C4502G	p.A1501G	VHLPGDLAGHSPAGAETQSPCYISQ	VHLPGDLAGHSPGGAETQSPCYISQ	3.0	4.0	-	-	4316_7:47897291-47897291 G>C_VHLPGDLAGHSPGGAETQSPCYISQ	0.0
5:148619409-148619409 T>C	0.0	4246	COLORECTAL	-	-	-	-	ABLIM3	ENST00000506113,p.S388P|uc003lqa.1,p.S334P|uc003lqc.1,p.S388P|uc003lpy.2,p.S388P|NM_001301028,p.S326P|uc003lqb.3,p.S326P|NM_001301027,p.S334P|NM_001301018,p.S388P|NM_014945,p.S388P|ENST00000356541,p.S326P|uc003lpz.1,p.S388P|ENST00000504238,p.S326P|uc003lqf.3,p.S326P|ENST00000326685,p.S326P|uc003lqe.1,p.S326P|NM_001301015,p.S388P|ENST00000508983,p.S388P|uc003lqd.1,p.S326P|ENST00000309868,p.S388P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lqf.3	nonsynonymous SNV	exon10	c.T976C	p.S326P	YIDSPTYSRQGMSPTFSRSPHHYYR	YIDSPTYSRQGMPPTFSRSPHHYYR	6.0	2.0	-	-	4246_5:148619409-148619409 T>C_YIDSPTYSRQGMPPTFSRSPHHYYR	0.0
2:74087201-74087201 G>T	1.0	4234	NSCLC	-	-	-	-	STAMBP	ENST00000394070,p.D381Y|NM_006463,p.D381Y|NM_201647,p.D381Y|uc002sju.3,p.D381Y|NM_213622,p.D381Y|ENST00000394073,p.D381Y|ENST00000339566,p.D381Y|uc002sjs.3,p.D381Y|ENST00000409707,p.D381Y|uc002sjv.3,p.D381Y	protein_coding, processed_transcript	uc002sjv.3	nonsynonymous SNV	exon9	c.G1141T	p.D381Y	PKFQETGFFKLTDHGLEEISSCRQK	PKFQETGFFKLTYHGLEEISSCRQK	9.0	5.0	-	-	4234_2:74087201-74087201 G>T_PKFQETGFFKLTYHGLEEISSCRQK	0.0
2:152695789-152695789 C>G	1.0	4284	COLORECTAL	-	-	-	-	CACNB4	ENST00000201943,p.K407N|uc002txz.3,p.K451N|uc002txy.3,p.K435N|NM_000726,p.K469N|NM_001005747,p.K435N|ENST00000539935,p.K469N|ENST00000534999,p.K435N|ENST00000427385,p.K451N|ENST00000439467,p.K464N|ENST00000397327,p.K422N|uc002tya.3,p.K469N|ENST00000360283,p.K436N|NM_001145798,p.K407N|NM_001005746,p.K451N|uc010fnz.3,p.K407N	retained_intron, protein_coding, processed_transcript	uc010fnz.3	nonsynonymous SNV	exon13	c.G1221C	p.K407N	TSDENYHNERARKSRNRLSSSSQHS	TSDENYHNERARNSRNRLSSSSQHS	4.0	5.0	-	-	4284_2:152695789-152695789 C>G_TSDENYHNERARNSRNRLSSSSQHS	0.0
5:140812775-140812775 ->T	0.0	4345	COLORECTAL	-	-	-	-	PCDHGA12	NM_032094,p.L817fs|uc011dba.2,p.L817fs	protein_coding	uc011dba.2	frameshift insertion	exon1	c.2450dupT	p.L817fs	GLIEVSLYQIFFLFFF	GLIEVSLYQIFFLFFFL	8.0	10.0	-	translate beyond stop codon PR	4345_5:140812775-140812775 ->T_GLIEVSLYQIFFLFFFL	0.0
2:27445408-27445408 G>T	0.0	4234	NSCLC	-	-	-	-	CAD	uc010eyw.3,p.G173W|NM_004341,p.G173W|uc002rji.3,p.G173W|ENST00000403525,p.G173W|ENST00000264705,p.G173W	retained_intron, protein_coding, processed_transcript	uc010eyw.3	nonsynonymous SNV	exon5	c.G517T	p.G173W	EVSIKTPRVFNTGGAPRILALDCGL	EVSIKTPRVFNTWGAPRILALDCGL	8.0	6.0	-	-	4234_2:27445408-27445408 G>T_EVSIKTPRVFNTWGAPRILALDCGL	0.0
2:220479947-220479947 C>T	1.0	3713	MELANOMA	-	-	-	-	STK11IP	ENST00000295641,p.P1012S|NM_052902,p.P1012S|uc002vml.3,p.P1012S|ENST00000456909,p.P1001S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002vml.3	nonsynonymous SNV	exon24	c.C3034T	p.P1012S	PAASGEASEKVPPSGPGPAVRVREQ	PAASGEASEKVPSSGPGPAVRVREQ	5.0	2.0	-	-	3713_2:220479947-220479947 C>T_PAASGEASEKVPSSGPGPAVRVREQ	0.0
6:93956590-93956590 T>G	0.0	4160	COLORECTAL	-	-	-	2	EPHA7	uc011eac.2,p.K878N|NM_004440,p.K882N|ENST00000369303,p.K882N|uc003pof.3,p.K877N|NM_001288629,p.K877N|uc003poe.3,p.K882N	protein_coding	uc011eac.2	nonsynonymous SNV	exon15	c.A2634C	p.K878N	LDCWQKERAERPKFEQIVGILDKMI	LDCWQKERAERPNFEQIVGILDKMI	1.0	2.0	-	-	4160_6:93956590-93956590 T>G_LDCWQKERAERPNFEQIVGILDKMI	0.0
4:114199081-114199081 C>G	0.0	4186	BREAST	-	-	-	-	ANK2	ENST00000503423,p.S570C	retained_intron, protein_coding, processed_transcript	ENST00000503423	nonsynonymous SNV	exon17	c.C1709G	p.S570C	AKLLLQRRAAADSAGKNGYTPLHIA	AKLLLQRRAAADCAGKNGYTPLHIA	2.0	7.0	-	-	4186_4:114199081-114199081 C>G_AKLLLQRRAAADCAGKNGYTPLHIA	0.0
7:122091488-122091488 C>T	1.0	3919	MELANOMA	-	-	-	-	CADPS2	uc022akr.1,p.R743K|ENST00000313070,p.R740K|uc010lkq.3,p.R740K|ENST00000449022,p.R743K|ENST00000412584,p.R740K|NM_017954,p.R743K|NM_001009571,p.R740K|uc003vkg.4,p.R440K|ENST00000334010,p.R744K|NM_001167940,p.R743K	protein_coding, processed_transcript	uc022akr.1	nonsynonymous SNV	exon15	c.G2228A	p.R743K	DGIGTVSVEEKERFEEIKERLSSLL	DGIGTVSVEEKEKFEEIKERLSSLL	3.0	7.0	-	-	3919_7:122091488-122091488 C>T_DGIGTVSVEEKEKFEEIKERLSSLL	0.0
12:113629545-113629545 C>T	1.0	2556	MELANOMA	-	-	ID=COSM1561823;OCCURENCE=1(large_intestine)	-	RITA1	NM_001286215,p.R269C|NM_032848,p.R245C|ENST00000549621,p.R245C|ENST00000548278,p.R245C|ENST00000552495,p.R269C|uc001tur.1,p.R245C	protein_coding	uc001tur.1	nonsynonymous SNV	exon4	c.C733T	p.R245C	VTFRSPLVTSRARSVSISVPSTPRR	VTFRSPLVTSRACSVSISVPSTPRR	7.0	4.0	-	-	2556_12:113629545-113629545 C>T_VTFRSPLVTSRACSVSISVPSTPRR	0.0
7:142460314-142460314 G>A	0.0	4326	BREAST	-	-	-	-	PRSS1	ENST00000486171,p.A177T|ENST00000492062,p.A113T|uc003wak.2,p.A163T|NM_002769,p.A163T|ENST00000311737,p.A163T|uc003wam.2,p.A103T	retained_intron, protein_coding	uc003wam.2	nonsynonymous SNV	exon2	c.G307A	p.A103T	GADYPDELQCLDAPVLSQAKCEASY	GADYPDELQCLDTPVLSQAKCEASY	3.0	1.0	-	-	4326_7:142460314-142460314 G>A_GADYPDELQCLDTPVLSQAKCEASY	0.0
14:24437989-24437989 C>G	0.0	4186	BREAST	-	-	-	-	DHRS4	ENST00000558263,p.C180W|ENST00000382761,p.C162W|NM_001282987,p.C180W	protein_coding	NM_001282987	nonsynonymous SNV	exon6	c.C540G	p.C180W	PADKKVRRARGLCWHRVFPVL	PADKKVRRARGLWWHRVFPVL	9.0	5.0	-	-	4186_14:24437989-24437989 C>G_PADKKVRRARGLWWHRVFPVL	0.0
17:55189857-55189857 C>G	1.0	4196	COLORECTAL	-	-	-	-	AKAP1	uc010dcm.3,p.Q661E|ENST00000571629,p.Q661E|NM_003488,p.Q661E|uc021uak.1,p.Q661E|uc010wnl.2,p.Q661E|NM_001242903,p.Q661E|ENST00000573326,p.Q243E|ENST00000337714,p.Q661E|NM_001242902,p.Q661E|ENST00000539273,p.Q661E|uc002iux.3,p.Q661E|ENST00000572557,p.Q661E	protein_coding, nonsense_mediated_decay	uc021uak.1	nonsynonymous SNV	exon6	c.C1981G	p.Q661E	TQSVQICHIEGSQHHVDKALNLIGK	TQSVQICHIEGSEHHVDKALNLIGK	10.0	9.0	-	-	4196_17:55189857-55189857 C>G_TQSVQICHIEGSEHHVDKALNLIGK	0.0
2:48033630-48033630 G>A	1.0	4189	MELANOMA	-	-	-	1	MSH6	ENST00000538136,p.E979K|ENST00000234420,p.E1281K|NM_001281494,p.E979K|NM_001281492,p.E1151K|NM_000179,p.E1281K|uc002rwd.4,p.E1281K|uc010fbj.3,p.E979K|NM_001281493,p.E979K|uc010yoj.2,p.E979K|ENST00000540021,p.E1151K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010yoj.2	nonsynonymous SNV	exon9	c.G2935A	p.E979K	CMVENECEDPSQETITFLYKFIKGA	CMVENECEDPSQKTITFLYKFIKGA	10.0	2.0	-	-	4189_2:48033630-48033630 G>A_CMVENECEDPSQKTITFLYKFIKGA	0.0
X:152914821-152914821 G>A	0.0	4095	COLORECTAL	-	-	-	-	DUSP9	uc004fhy.4,p.D170N|NM_001395,p.D170N|ENST00000342782,p.D170N|uc004fhx.4,p.D170N|ENST00000370167,p.D170N	protein_coding, processed_transcript	uc004fhy.4	nonsynonymous SNV	exon3	c.G508A	p.D170N	PVVGLGSLCLGSDCSDAESEADRDS	PVVGLGSLCLGSNCSDAESEADRDS	2.0	7.0	-	-	4095_X:152914821-152914821 G>A_PVVGLGSLCLGSNCSDAESEADRDS	0.0
1:26135580-26135580 C>T	1.0	3466	MELANOMA	-	-	-	-	SEPN1	ENST00000354177,p.P237S	protein_coding, processed_transcript	ENST00000354177	nonsynonymous SNV	exon5	c.C709T	p.P237S	FHPRPFVKTRFAPQGAVACLTAISD	FHPRPFVKTRFASQGAVACLTAISD	10.0	7.0	-	-	3466_1:26135580-26135580 C>T_FHPRPFVKTRFASQGAVACLTAISD	0.0
X:63410414-63410414 G>A	1.0	3879	MELANOMA	-	-	-	1	AMER1	NM_152424,p.S918F|uc022byb.1,p.S918F|uc004dvo.3,p.S918F|ENST00000330258,p.S918F	protein_coding	uc022byb.1	nonsynonymous SNV	exon1	c.C2753T	p.S918F	LSNSHLVQGYLESDELQAQQEDSDE	LSNSHLVQGYLEFDELQAQQEDSDE	5.0	10.0	-	-	3879_X:63410414-63410414 G>A_LSNSHLVQGYLEFDELQAQQEDSDE	0.0
12:3757673-3757673 G>T	0.0	4326	BREAST	-	-	-	-	CRACR2A	uc001qmj.2,p.P385T|NM_032680,p.P385T|ENST00000252322,p.P385T	protein_coding, processed_transcript, nonsense_mediated_decay	uc001qmj.2	nonsynonymous SNV	exon11	c.C1153A	p.P385T	RCVGGHWPVLRAPPRSLGSEGPV	RCVGGHWPVLRATPRSLGSEGPV	5.0	1.0	-	-	4326_12:3757673-3757673 G>T_RCVGGHWPVLRATPRSLGSEGPV	0.0
7:2962271-2962271 C>T	0.0	2591	MELANOMA	-	-	ID=COSM1292494;OCCURENCE=1(skin),1(haematopoietic_and_lymphoid_tissue)	1	CARD11	NM_032415,p.E756K|ENST00000355508,p.E227K|uc003smv.3,p.E756K|ENST00000396946,p.E756K	retained_intron, protein_coding	uc003smv.3	nonsynonymous SNV	exon17	c.G2266A	p.E756K	SGPVTLHYKVNHEGYRKLVKDMEDG	SGPVTLHYKVNHKGYRKLVKDMEDG	1.0	2.0	-	-	2591_7:2962271-2962271 C>T_SGPVTLHYKVNHKGYRKLVKDMEDG	0.0
14:20943231-20943231 C>T	1.0	3466	MELANOMA	-	-	-	-	PNP	uc001vxo.4,p.R158C|ENST00000361505,p.R158C|NM_000270,p.R158C|ENST00000553591,p.R197C|uc021rns.1,p.R29C	retained_intron, protein_coding	uc021rns.1	nonsynonymous SNV	exon2	c.C85T	p.R29C	PLRGPNDERFGDRFPAMSDAYDRTM	PLRGPNDERFGDCFPAMSDAYDRTM	8.0	4.0	-	-	3466_14:20943231-20943231 C>T_PLRGPNDERFGDCFPAMSDAYDRTM	0.0
11:55135612-55135612 T>A	0.0	4281	COLORECTAL	-	-	-	-	OR4A15	uc010rif.2,p.S85T|ENST00000314706,p.S85T|NM_001005275,p.S85T	protein_coding	uc010rif.2	nonsynonymous SNV	exon1	c.T253A	p.S85T	IIVTIMASQSLGSPMYFFLASLSFI	IIVTIMASQSLGTPMYFFLASLSFI	1.0	4.0	-	-	4281_11:55135612-55135612 T>A_IIVTIMASQSLGTPMYFFLASLSFI	0.0
5:125911121-125911121 G>T	1.0	4180	BREAST	-	-	-	-	ALDH7A1	ENST00000553117,p.A229D|NM_001201377,p.A201D|ENST00000409134,p.A229D|ENST00000510111,p.A200D|NM_001202404,p.A256D|NM_001182,p.A229D|uc011cxa.2,p.A256D|ENST00000447989,p.A256D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cxa.2	nonsynonymous SNV	exon7	c.C767A	p.A256D	WKGAPTTSLISVAVTKIIAKVLEDN	WKGAPTTSLISVDVTKIIAKVLEDN	9.0	4.0	-	-	4180_5:125911121-125911121 G>T_WKGAPTTSLISVDVTKIIAKVLEDN	0.0
19:39329617-39329617 ->A	0.0	3998	MELANOMA	-	-	-	-	HNRNPL	uc002ojk.3,p.V80fs|uc002ojp.1,p.V80fs|ENST00000600873,p.V291fs|NM_001005335,p.V291fs|uc002ojl.3,p.V80fs|NM_001533,p.V424fs|uc021uui.1,p.V291fs|ENST00000221419,p.V424fs|uc021uuh.1,p.V424fs|uc002ojj.1,p.V80fs	retained_intron, protein_coding, nonsense_mediated_decay	uc021uui.1	frameshift insertion	exon9	c.872dupT	p.V291fs	VKFMKSKPGAAMVEMADGYAVDRAI	VKFMKSKPGAAMVGDG	10.0	9.0	-	-	3998_19:39329617-39329617 ->A_VKFMKSKPGAAMVGDG	0.0
17:7127020-7127020 G>A	1.0	3775	CERVICAL	-	-	-	-	ACADVL	ENST00000543245,p.E437K|uc002gev.4,p.E414K|ENST00000350303,p.E392K|uc002gex.4,p.E338K|NM_001033859,p.E392K|uc002gew.4,p.E392K|NM_001270447,p.E437K|uc010vtp.3,p.E437K|ENST00000356839,p.E414K|NM_001270448,p.E338K|NM_000018,p.E414K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vtp.3	nonsynonymous SNV	exon13	c.G1309A	p.E437K	ANMDQGATDFQIEAAISKIFGSEAA	ANMDQGATDFQIKAAISKIFGSEAA	10.0	10.0	-	-	3775_17:7127020-7127020 G>A_ANMDQGATDFQIKAAISKIFGSEAA	0.0
4:138452830-138452830 G>A	1.0	3919	MELANOMA	-	-	-	-	PCDH18	uc003ihe.4,p.S138L|NM_019035,p.S138L|ENST00000344876,p.S138L|ENST00000412923,p.S138L|NM_001300828,p.S138L|uc003ihf.4,p.S131L	protein_coding	uc003ihf.4	nonsynonymous SNV	exon1	c.C392T	p.S131L	EVLDINDNSPQFSRSLIPIEISESA	EVLDINDNSPQFLRSLIPIEISESA	1.0	10.0	-	-	3919_4:138452830-138452830 G>A_EVLDINDNSPQFLRSLIPIEISESA	0.0
X:54497148-54497148 G>-	1.0	4259	COLORECTAL	-	-	ID=COSM1468675;OCCURENCE=3(large_intestine)	-	FGD1	NM_004463,p.P176fs|uc004dtg.3,p.P176fs|ENST00000375135,p.P176fs	protein_coding	uc004dtg.3	frameshift deletion	exon3	c.527delC	p.P176fs	KPSYLQMPRMPPPLEPIPPPPSRPL	KPSYLQMPRMPPHWSPSPLHHHAHCLPTPEWPRAWLPGQRPAPVLQQYPH	4.0	5.0	-	-	4259_X:54497148-54497148 G>-_KPSYLQMPRMPPHWSPSPLHHHAHCLPTPEWPRAWLPGQRPAPVLQQYPH	0.0
12:21682018-21682018 G>A	0.0	2556	MELANOMA	-	-	-	-	SPX	NM_030572,p.D98N|ENST00000256969,p.D98N|uc001rfa.1,p.D98N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rfa.1	nonsynonymous SNV	exon5	c.G292A	p.D98N	TILLASLQKSPEDEEKNFDQTRFLE	TILLASLQKSPENEEKNFDQTRFLE	4.0	3.0	-	-	2556_12:21682018-21682018 G>A_TILLASLQKSPENEEKNFDQTRFLE	0.0
3:45963271-45963271 T>G	1.0	4136	BREAST	-	-	-	-	FYCO1	uc003cpb.5,p.S1475R|ENST00000535325,p.S1495R|ENST00000438446,p.S146R|ENST00000296137,p.S1475R|NM_024513,p.S1475R|uc011bal.1,p.S1495R	retained_intron, protein_coding	uc011bal.1	nonsynonymous SNV	exon18	c.A4483C	p.S1495R	HLTVDRPVIYDGSDFL	HLTVDRPVIYDGRDFL	7.0	6.0	-	-	4136_3:45963271-45963271 T>G_HLTVDRPVIYDGRDFL	0.0
4:119239674-119239674 C>T	1.0	3713	MELANOMA	-	-	-	-	PRSS12	ENST00000296498,p.E337K|NM_003619,p.E337K|uc003ica.2,p.E337K	retained_intron, protein_coding, processed_transcript	uc003ica.2	nonsynonymous SNV	exon5	c.G1009A	p.E337K	GIAKAWHQAYFGEGSGPVMLDEVRC	GIAKAWHQAYFGKGSGPVMLDEVRC	3.0	9.0	-	-	3713_4:119239674-119239674 C>T_GIAKAWHQAYFGKGSGPVMLDEVRC	0.0
1:27939744-27939744 C>T	0.0	3795	MELANOMA	-	-	-	-	FGR	NM_001042747,p.R456Q|NM_001042729,p.R456Q|uc001boj.3,p.R456Q|ENST00000374003,p.R456Q|ENST00000374004,p.R456Q|uc001bok.3,p.R456Q|uc001boi.3,p.R159Q|ENST00000399173,p.R456Q|uc001bom.3,p.R456Q|uc001bol.3,p.R456Q|ENST00000374005,p.R456Q|ENST00000545953,p.R390Q|NM_005248,p.R456Q	protein_coding, processed_transcript	uc001bom.3	nonsynonymous SNV	exon12	c.G1367A	p.R456Q	FGILLTELITKGRIPYPGMNKREVL	FGILLTELITKGQIPYPGMNKREVL	4.0	8.0	-	-	3795_1:27939744-27939744 C>T_FGILLTELITKGQIPYPGMNKREVL	0.0
13:28143271-28143271 C>T	1.0	2556	MELANOMA	-	-	-	-	LNX2	uc001url.4,p.G184S|NM_153371,p.G184S|uc001urm.1,p.G184S|ENST00000316334,p.G184S	protein_coding	uc001urm.1	nonsynonymous SNV	exon3	c.G550A	p.G184S	GTLSPEADCLGTGAVPVERHLTSAS	GTLSPEADCLGTSAVPVERHLTSAS	7.0	8.0	-	-	2556_13:28143271-28143271 C>T_GTLSPEADCLGTSAVPVERHLTSAS	0.0
12:53070889-53070889 C>T	0.0	4245	COLORECTAL	-	-	-	-	KRT1	ENST00000252244,p.R403H|NM_006121,p.R403H|uc001sav.1,p.R403H|uc001sau.1,p.R403H	retained_intron, protein_coding	uc001sav.1	nonsynonymous SNV	exon6	c.G1208A	p.R403H	VRNSKIEISELNRVIQRLRSEIDNV	VRNSKIEISELNHVIQRLRSEIDNV	4.0	10.0	-	-	4245_12:53070889-53070889 C>T_VRNSKIEISELNHVIQRLRSEIDNV	0.0
2:138400076-138400076 G>A	0.0	4235	COLORECTAL	-	-	-	-	THSD7B	ENST00000272643,p.R1276Q|ENST00000409968,p.R1273Q|ENST00000413152,p.R1245Q	retained_intron, protein_coding, processed_transcript	ENST00000413152	nonsynonymous SNV	exon21	c.G3734A	p.R1245Q	QTCGHGGRMSRTRFIIMPTQGEGRP	QTCGHGGRMSRTQFIIMPTQGEGRP	2.0	5.0	-	-	4235_2:138400076-138400076 G>A_QTCGHGGRMSRTQFIIMPTQGEGRP	0.0
22:31521399-31521399 C>T	0.0	3775	CERVICAL	-	-	-	-	INPP5J	uc011alk.2,p.S158L|ENST00000412277,p.S158L|NM_001284286,p.S158L|ENST00000331075,p.S225L|NM_001284285,p.S225L|uc003aju.4,p.S225L|uc010gwf.3,p.S225L	retained_intron, protein_coding, processed_transcript	uc011alk.2	nonsynonymous SNV	exon3	c.C473T	p.S158L	TQEQALAPASTASGAASVGQTSARK	TQEQALAPASTALGAASVGQTSARK	3.0	9.0	-	-	3775_22:31521399-31521399 C>T_TQEQALAPASTALGAASVGQTSARK	0.0
15:22954270-22954270 C>T	1.0	3713	MELANOMA	-	-	-	-	CYFIP1	ENST00000560848,p.H474Y|NM_001287810,p.H474Y|uc001yus.3,p.H474Y|uc010aya.1,p.H502Y|uc001yut.3,p.H474Y|NM_014608,p.H474Y|ENST00000313077,p.H474Y	retained_intron, protein_coding, nonsense_mediated_decay	uc010aya.1	nonsynonymous SNV	exon13	c.C1504T	p.H502Y	QVLMGRMESVFNHAIRHTVYAALQD	QVLMGRMESVFNYAIRHTVYAALQD	7.0	8.0	-	-	3713_15:22954270-22954270 C>T_QVLMGRMESVFNYAIRHTVYAALQD	0.0
6:44116291-44116291 C>T	1.0	3466	MELANOMA	-	-	-	-	TMEM63B	uc003ows.3,p.T291I|ENST00000259746,p.T388I|uc003owr.3,p.T388I|NM_018426,p.T388I|ENST00000323267,p.T388I|uc003owq.1,p.T388I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ows.3	nonsynonymous SNV	exon11	c.C872T	p.T291I	LKDFNVCKCQGCTCRGEPRPSSCSE	LKDFNVCKCQGCICRGEPRPSSCSE	8.0	9.0	-	-	3466_6:44116291-44116291 C>T_LKDFNVCKCQGCICRGEPRPSSCSE	0.0
4:145039891-145039891 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GYPA	uc003ijp.4,p.L51I|ENST00000504786,p.L51I	retained_intron, protein_coding, nonsense_mediated_decay	uc003ijp.4	nonsynonymous SNV	exon3	c.C151A	p.L51I	YISSQTNGERVQLAHHFSEPEITLI	YISSQTNGERVQIAHHFSEPEITLI	1.0	9.0	-	-	4258_4:145039891-145039891 G>T_YISSQTNGERVQIAHHFSEPEITLI	0.0
7:1526409-1526409 C>G	1.0	4071	COLORECTAL	-	-	-	-	INTS1	uc003skn.2,p.R943T|NM_001080453,p.R943T|ENST00000389470,p.R1086T|uc003skp.1,p.R290T|ENST00000404767,p.R943T	retained_intron, protein_coding, processed_transcript	uc003skp.1	nonsynonymous SNV	exon8	c.G869C	p.R290T	GESKEQKAKKRQRQQKQRQLLGRLQ	GESKEQKAKKRQTQQKQRQLLGRLQ	9.0	1.0	-	-	4071_7:1526409-1526409 C>G_GESKEQKAKKRQTQQKQRQLLGRLQ	0.0
1:227171317-227171317 G>A	1.0	4180	BREAST	-	-	-	-	ADCK3	uc001hqo.1,p.S103N|uc009xeq.1,p.S330N|uc001hqn.1,p.S382N|uc010pvq.1,p.S103N|ENST00000433743,p.S56N|ENST00000366779,p.S382N|ENST00000366778,p.S330N|ENST00000366777,p.S382N|uc010pvr.1,p.S56N|uc001hqm.1,p.S382N|ENST00000458507,p.S103N|NM_020247,p.S382N|ENST00000366776,p.S307N|ENST00000366775,p.S227N	protein_coding, processed_transcript	uc010pvr.1	nonsynonymous SNV	exon5	c.G167A	p.S56N	SDVNNLMAVLNMSNMLPEGLFPEHL	SDVNNLMAVLNMNNMLPEGLFPEHL	9.0	7.0	-	-	4180_1:227171317-227171317 G>A_SDVNNLMAVLNMNNMLPEGLFPEHL	0.0
8:97318737-97318737 T>G	1.0	4071	COLORECTAL	-	-	-	-	PTDSS1	ENST00000517309,p.S320R|NM_014754,p.S320R|ENST00000455950,p.S174R|ENST00000522072,p.S117R|NM_001290225,p.S174R|uc003yht.1,p.S320R|uc003yhu.1,p.S174R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003yhu.1	nonsynonymous SNV	exon6	c.T522G	p.S174R	KHIFVFQASHPLSWGRILFIGGITA	KHIFVFQASHPLRWGRILFIGGITA	9.0	2.0	-	-	4071_8:97318737-97318737 T>G_KHIFVFQASHPLRWGRILFIGGITA	0.0
2:168103957-168103957 C>T	0.0	2591	MELANOMA	-	-	-	-	XIRP2	NM_152381,p.P2019S|uc010fpq.3,p.P1797S|uc002udy.3,p.P1844S|uc002udx.3,p.P2019S|ENST00000409273,p.P1797S|NM_001199144,p.P1797S|ENST00000409195,p.P2019S|ENST00000295237,p.P2019S	protein_coding	uc010fpq.3	nonsynonymous SNV	exon7	c.C5389T	p.P1797S	GNLVEERTEVNLPKAPKGTVKIVID	GNLVEERTEVNLSKAPKGTVKIVID	1.0	8.0	-	-	2591_2:168103957-168103957 C>T_GNLVEERTEVNLSKAPKGTVKIVID	0.0
12:25398284-25398284 C>T	1.0	4095	COLORECTAL	-	-	ID=COSM521,COSM1135366;OCCURENCE=1(salivary_gland),171(endometrium),265(ovary),20(soft_tissue),19(urinary_tract),1(kidney),2323(pancreas),15(liver),3(eye),22(prostate),321(biliary_tract),6237(large_intestine),18(breast),24(skin),58(small_intestine),25(upper_aerodigestive_tract),10(oesophagus),4(central_nervous_system),93(stomach),2(testis),19(cervix),114(haematopoietic_and_lymphoid_tissue),15(gastrointestinal_tract_(site_indeterminate)),37(thyroid),737(lung),25(peritoneum)	1	KRAS	NM_004985,p.G12D|NM_033360,p.G12D|uc001rgp.1,p.G12D|ENST00000557334,p.G12D|uc001rgq.1,p.G12D|ENST00000311936,p.G12D|ENST00000256078,p.G12D|ENST00000556131,p.G12D	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35A	p.G12D	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGADGVGKSALTIQLI	9.0	6.0	CD8	-	4095_12:25398284-25398284 C>T_MTEYKLVVVGADGVGKSALTIQLI	1.0
X:151935260-151935260 G>A	1.0	3879	MELANOMA	-	-	-	-	MAGEA3	uc004fgp.3,p.P303S|ENST00000370278,p.P303S|NM_005362,p.P303S|uc022chl.1,p.P303S|ENST00000393902,p.P303S	protein_coding	uc022chl.1	nonsynonymous SNV	exon1	c.C907T	p.P303S	VKISGGPHISYPPLHEWVLREGEE	VKISGGPHISYPSLHEWVLREGEE	7.0	10.0	-	-	3879_X:151935260-151935260 G>A_VKISGGPHISYPSLHEWVLREGEE	0.0
3:38945468-38945468 G>A	0.0	4316	COLORECTAL	-	-	ID=COSM1422884;OCCURENCE=1(large_intestine)	-	SCN11A	ENST00000450244,p.P577L|NM_014139,p.P577L|uc021wvy.1,p.P577L|ENST00000444237,p.P577L|ENST00000456224,p.P577L|ENST00000302328,p.P577L|NM_001287223,p.P577L	protein_coding	uc021wvy.1	nonsynonymous SNV	exon12	c.C1730T	p.P577L	CVKKVLRTVMTDPFTELAITICIII	CVKKVLRTVMTDLFTELAITICIII	1.0	7.0	-	-	4316_3:38945468-38945468 G>A_CVKKVLRTVMTDLFTELAITICIII	0.0
2:179598064-179598064 T>G	0.0	4245	COLORECTAL	-	-	-	-	TTN	ENST00000342992,p.K4075T|uc031rqd.1,p.K5002T|uc002umz.1,p.K736T|ENST00000591111,p.K5002T|NM_133378,p.K4075T|ENST00000589042,p.K5319T|uc031rqc.1,p.K5319T|uc021vsy.2,p.K4075T|NM_001256850,p.K5002T|NM_001267550,p.K5319T	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon52	c.A15005C	p.K5002T	YRISFKNNVAQLKFYSAELHDSGQY	YRISFKNNVAQLTFYSAELHDSGQY	5.0	5.0	-	-	4245_2:179598064-179598064 T>G_YRISFKNNVAQLTFYSAELHDSGQY	0.0
3:197518226-197518226 C>A	1.0	4000	MELANOMA	-	-	-	-	LRCH3	uc011bul.1,p.P26H|ENST00000443727,p.P26H|ENST00000441090,p.P26H|ENST00000438796,p.P26H|uc003fyj.1,p.P26H|ENST00000425562,p.P26H|ENST00000334859,p.P26H|NM_032773,p.P26H|uc011bun.1,p.P26H|ENST00000414675,p.P26H|uc011bum.1,p.P26H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bun.1	nonsynonymous SNV	exon1	c.C77A	p.P26H	EYSGTVASGGNLPGVHCGPSSGAGP	EYSGTVASGGNLHGVHCGPSSGAGP	10.0	9.0	-	-	4000_3:197518226-197518226 C>A_EYSGTVASGGNLHGVHCGPSSGAGP	0.0
1:145487372-145487372 G>T	1.0	4095	COLORECTAL	-	-	-	-	LIX1L	ENST00000369308,p.G121W|NM_153713,p.G121W|uc001enr.3,p.G121W	protein_coding	uc001enr.3	nonsynonymous SNV	exon2	c.G361T	p.G121W	QMKQSRGADLKNGALVVYEMVPSNS	QMKQSRGADLKNWALVVYEMVPSNS	8.0	6.0	-	-	4095_1:145487372-145487372 G>T_QMKQSRGADLKNWALVVYEMVPSNS	0.0
10:16981131-16981131 T>C	1.0	3678	MELANOMA	-	-	-	-	CUBN	NM_001081,p.N1855S|ENST00000377833,p.N1855S|uc001ioo.3,p.N1855S	protein_coding	uc001ioo.3	nonsynonymous SNV	exon38	c.A5564G	p.N1855S	FQATFMKIFGNDNIVGTHGKVASPF	FQATFMKIFGNDSIVGTHGKVASPF	6.0	2.0	-	-	3678_10:16981131-16981131 T>C_FQATFMKIFGNDSIVGTHGKVASPF	0.0
5:140580161-140580161 G>A	1.0	2556	MELANOMA	-	-	-	-	PCDHB11	uc003liy.3,p.G272R|NM_018931,p.G272R|ENST00000354757,p.G272R	protein_coding	uc003liy.3	nonsynonymous SNV	exon1	c.G814A	p.G272R	LILIVSAWDLDSGTNGEICYTFSHA	LILIVSAWDLDSRTNGEICYTFSHA	5.0	6.0	-	-	2556_5:140580161-140580161 G>A_LILIVSAWDLDSRTNGEICYTFSHA	0.0
X:102755347-102755347 T>G	1.0	4284	COLORECTAL	-	-	-	-	RAB40A	uc004ekk.3,p.E113A|ENST00000372633,p.E113A|ENST00000304236,p.E113A|uc022cbs.1,p.E113A|NM_080879,p.E113A	protein_coding	uc022cbs.1	nonsynonymous SNV	exon1	c.A338C	p.E113A	SFEGMDRWIKKIEEHAPGVPKILVG	SFEGMDRWIKKIAEHAPGVPKILVG	4.0	6.0	-	-	4284_X:102755347-102755347 T>G_SFEGMDRWIKKIAEHAPGVPKILVG	0.0
5:171765929-171765929 C>G	0.0	4240	BREAST	-	-	-	-	SH3PXD2B	ENST00000311601,p.R727T|NM_001017995,p.R727T|uc003mbr.3,p.R727T	protein_coding, processed_transcript	uc003mbr.3	nonsynonymous SNV	exon13	c.G2180C	p.R727T	KQDGLSPKEISCRAPPRPAKTTDPV	KQDGLSPKEISCTAPPRPAKTTDPV	6.0	6.0	-	-	4240_5:171765929-171765929 C>G_KQDGLSPKEISCTAPPRPAKTTDPV	0.0
13:102029307-102029307 C>T	0.0	4213	COLORECTAL	-	-	-	-	NALCN	uc001vpa.2,p.R159Q|ENST00000376196,p.R159Q|uc001vox.1,p.R159Q|ENST00000376200,p.R159Q|ENST00000251127,p.R159Q|uc001voz.2,p.R159Q|NM_052867,p.R159Q	retained_intron, protein_coding, processed_transcript	uc001vpa.2	nonsynonymous SNV	exon5	c.G476A	p.R159Q	PLIMIRAFRIYFRFELPRTRITNIL	PLIMIRAFRIYFQFELPRTRITNIL	5.0	10.0	-	-	4213_13:102029307-102029307 C>T_PLIMIRAFRIYFQFELPRTRITNIL	0.0
14:19566033-19566033 C>G	0.0	4326	BREAST	-	-	-	-	POTEG	NM_001005356,p.D359E|ENST00000547889,p.D359E|uc001vuz.1,p.D359E|ENST00000409832,p.D359E	protein_coding, nonsense_mediated_decay	uc001vuz.1	nonsynonymous SNV	exon6	c.C1077G	p.D359E	SSHHNVICQLLSDYKEKQMLKVSSE	SSHHNVICQLLSEYKEKQMLKVSSE	4.0	3.0	-	-	4326_14:19566033-19566033 C>G_SSHHNVICQLLSEYKEKQMLKVSSE	0.0
14:93649843-93649843 C>T	1.0	4234	NSCLC	-	-	-	-	MOAP1	ENST00000556883,p.E249K|NM_022151,p.E249K|ENST00000298894,p.E249K|uc001ybj.3,p.E249K|uc021saw.1,p.E249K	protein_coding	uc021saw.1	nonsynonymous SNV	exon1	c.G745A	p.E249K	LEEVFGVTDNPRELQVKYLTTYQKD	LEEVFGVTDNPRKLQVKYLTTYQKD	8.0	3.0	-	-	4234_14:93649843-93649843 C>T_LEEVFGVTDNPRKLQVKYLTTYQKD	0.0
10:104679735-104679735 T>A	0.0	4335	COLORECTAL	-	-	-	-	CNNM2	uc001kwn.3,p.L500M|ENST00000457502,p.L258M|ENST00000433628,p.L500M|uc001kwl.3,p.L500M|NM_017649,p.L500M|ENST00000369875,p.L500M|ENST00000369878,p.L500M|NM_199076,p.L500M|NM_199077,p.L500M|uc001kwm.3,p.L500M	protein_coding, processed_transcript	uc001kwn.3	nonsynonymous SNV	exon1	c.T1498A	p.L500M	RSNIVDLLFVKDLAFVDPDDCTPLK	RSNIVDLLFVKDMAFVDPDDCTPLK	7.0	6.0	-	-	4335_10:104679735-104679735 T>A_RSNIVDLLFVKDMAFVDPDDCTPLK	0.0
3:122632712-122632712 C>T	0.0	4258	ENDOMETRIAL	-	-	ID=COSM1536202,COSM1536203;OCCURENCE=1(lung)	-	SEMA5B	uc031sbm.1,p.E763K|ENST00000195173,p.E709K|NM_001256348,p.E651K|ENST00000393583,p.E709K|NM_001031702,p.E709K|uc010hro.2,p.E651K|ENST00000357599,p.E709K|uc011bju.2,p.E651K|ENST00000451055,p.E763K|uc003egb.2,p.E709K|NM_001256347,p.E763K|uc003efz.2,p.E709K|NM_001256346,p.E709K|ENST00000475244,p.E709K	protein_coding, processed_transcript, nonsense_mediated_decay	uc031sbm.1	nonsynonymous SNV	exon15	c.G2287A	p.E763K	RHGGRICVGKSREERFCNENTPCPV	RHGGRICVGKSRKERFCNENTPCPV	5.0	7.0	-	-	4258_3:122632712-122632712 C>T_RHGGRICVGKSRKERFCNENTPCPV	0.0
8:121644686-121644686 T>G	0.0	4246	COLORECTAL	-	-	-	-	SNTB1	uc010mdg.3,p.K332Q|ENST00000517992,p.K332Q|ENST00000395601,p.K332Q|NM_021021,p.K332Q|uc003ype.3,p.K332Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc010mdg.3	nonsynonymous SNV	exon3	c.A994C	p.K332Q	SREIRHLGWLAEKVPGESKKQWKPA	SREIRHLGWLAEQVPGESKKQWKPA	8.0	2.0	-	-	4246_8:121644686-121644686 T>G_SREIRHLGWLAEQVPGESKKQWKPA	0.0
6:17675906-17675906 G>A	1.0	3879	MELANOMA	-	-	-	-	NUP153	NM_001278209,p.P144S|ENST00000537253,p.P144S|uc003ncd.2,p.P144S|NM_001278210,p.P144S|uc011dje.2,p.P144S|uc010jpl.2,p.P144S|ENST00000262077,p.P144S|NM_005124,p.P144S	protein_coding	uc011dje.2	nonsynonymous SNV	exon3	c.C430T	p.P144S	HRSHLNFSMLESPALHCQPSTSSAF	HRSHLNFSMLESSALHCQPSTSSAF	9.0	9.0	-	-	3879_6:17675906-17675906 G>A_HRSHLNFSMLESSALHCQPSTSSAF	0.0
6:30955865-30955865 G>A	0.0	3903	MELANOMA	-	-	-	-	MUC21	ENST00000376296,p.G532E|uc021yuf.1,p.G516E|NM_001010909,p.G532E|uc003nsh.2,p.G532E|ENST00000486149,p.G78E	protein_coding	uc021yuf.1	nonsynonymous SNV	exon2	c.G1547A	p.G516E	HGLNHGLGPGPGGNHGAPHRPRWSP	HGLNHGLGPGPGENHGAPHRPRWSP	1.0	9.0	-	-	3903_6:30955865-30955865 G>A_HGLNHGLGPGPGENHGAPHRPRWSP	0.0
17:30500899-30500899 A>T	1.0	4234	NSCLC	-	-	-	-	RHOT1	ENST00000581031,p.E49V|NM_001033566,p.E49V|uc002hgy.3,p.E49V|NM_001288755,p.E28V|NM_018307,p.E49V|ENST00000394692,p.E49V|uc002hgv.3,p.E49V|NM_001288754,p.E49V|uc002hhb.3,p.E28V|uc010wby.2,p.E49V|NM_001033568,p.E49V|ENST00000354266,p.E28V|ENST00000581094,p.E49V|ENST00000358365,p.E49V|ENST00000545287,p.E49V|ENST00000333942,p.E49V|uc002hgw.3,p.E49V|uc002hgz.3,p.E49V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wby.2	nonsynonymous SNV	exon3	c.A146T	p.E49V	AEEITIPADVTPERVPTHIVDYSEA	AEEITIPADVTPVRVPTHIVDYSEA	9.0	9.0	-	-	4234_17:30500899-30500899 A>T_AEEITIPADVTPVRVPTHIVDYSEA	0.0
9:33798546-33798546 G>T	0.0	4046	OVARIAN	-	-	-	-	PRSS3	ENST00000361005,p.A230S|uc022bfu.1,p.A166S|NM_002771,p.A173S|ENST00000342836,p.A187S|uc003ztj.4,p.A230S|ENST00000379405,p.A173S|NM_001197097,p.A187S|NM_007343,p.A230S|uc003ztl.4,p.A173S|NM_001197098,p.A166S|ENST00000429677,p.A166S|uc003zti.4,p.A187S	protein_coding, processed_transcript	uc022bfu.1	nonsynonymous SNV	exon4	c.G496T	p.A166S	LDAPVLTQAECKASYPGKITNSMFC	LDAPVLTQAECKSSYPGKITNSMFC	6.0	3.0	-	-	4046_9:33798546-33798546 G>T_LDAPVLTQAECKSSYPGKITNSMFC	0.0
15:43668777-43668777 C>T	1.0	4000	MELANOMA	-	-	-	-	TUBGCP4	NM_014444,p.S95F|ENST00000260383,p.S95F|ENST00000564079,p.S95F|uc001zrn.3,p.S95F|NM_001286414,p.S95F|uc001zro.3,p.S95F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zro.3	nonsynonymous SNV	exon3	c.C284T	p.S95F	GIYLRAFCTGLDSVLQPYRQALLDL	GIYLRAFCTGLDFVLQPYRQALLDL	7.0	10.0	-	-	4000_15:43668777-43668777 C>T_GIYLRAFCTGLDFVLQPYRQALLDL	0.0
6:138656191-138656191 T>G	0.0	4345	COLORECTAL	-	-	-	-	KIAA1244	NM_020340,p.L2070V|ENST00000251691,p.L2070V|uc003qhu.3,p.L2070V	protein_coding	uc003qhu.3	nonsynonymous SNV	exon33	c.T6208G	p.L2070V	GQDSPLLQRPQHLMDQGQMRHSFSA	GQDSPLLQRPQHVMDQGQMRHSFSA	5.0	4.0	-	-	4345_6:138656191-138656191 T>G_GQDSPLLQRPQHVMDQGQMRHSFSA	0.0
2:108622514-108622514 G>A	0.0	2359	MELANOMA	-	-	-	-	SLC5A7	NM_021815,p.G251R|uc002tdv.3,p.G251R|ENST00000540517,p.G146R|uc010fjj.3,p.G251R|ENST00000264047,p.G251R|uc010ywn.2,p.G138R|ENST00000409059,p.G251R	protein_coding	uc010ywn.2	nonsynonymous SNV	exon6	c.G412A	p.G138R	SWLDSFLLLMLGGIPWQAYFQRVLS	SWLDSFLLLMLGRIPWQAYFQRVLS	1.0	7.0	-	-	2359_2:108622514-108622514 G>A_SWLDSFLLLMLGRIPWQAYFQRVLS	0.0
2:148733485-148733485 C>G	0.0	4196	COLORECTAL	-	-	-	-	ORC4	ENST00000535373,p.E15Q|ENST00000457954,p.E15Q|ENST00000264169,p.E15Q|NM_181741,p.E15Q|uc002twj.3,p.E15Q|ENST00000392858,p.E15Q|uc021vqr.1,p.E15Q|NM_001190879,p.E15Q|NM_181742,p.E15Q|ENST00000440042,p.E15Q|uc002twk.3,p.E15Q|ENST00000416719,p.E15Q|ENST00000392857,p.E15Q|uc010zbr.2,p.E15Q|uc002twi.3,p.E15Q|NM_002552,p.E15Q	retained_intron, protein_coding, processed_transcript	uc021vqr.1	nonsynonymous SNV	exon3	c.G43C	p.E15Q	SRKSKSNSLIHTECLSQVQRILRER	SRKSKSNSLIHTQCLSQVQRILRER	10.0	8.0	-	-	4196_2:148733485-148733485 C>G_SRKSKSNSLIHTQCLSQVQRILRER	0.0
8:99962995-99962995 T>A	0.0	4155	MELANOMA	-	-	-	-	OSR2	ENST00000523368,p.F256L|uc010mbn.2,p.F256L	protein_coding, processed_transcript	uc010mbn.2	nonsynonymous SNV	exon3	c.T768A	p.F256L	AVHKTLHMQVSLFSCLKTVAGSCYH	AVHKTLHMQVSLLSCLKTVAGSCYH	4.0	8.0	-	-	4155_8:99962995-99962995 T>A_AVHKTLHMQVSLLSCLKTVAGSCYH	0.0
4:81504276-81504276 A>C	0.0	2591	MELANOMA	-	-	-	-	C4orf22	ENST00000358105,p.Q91P|uc003hmf.3,p.Q91P|ENST00000513920,p.Q91P|NM_152770,p.Q91P|NM_001206997,p.Q91P|uc010ijp.3,p.Q91P|ENST00000508675,p.Q91P	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ijp.3	nonsynonymous SNV	exon3	c.A272C	p.Q91P	QQKTLTSAGKDLQDNFLTALAMREE	QQKTLTSAGKDLPDNFLTALAMREE	1.0	6.0	-	-	2591_4:81504276-81504276 A>C_QQKTLTSAGKDLPDNFLTALAMREE	0.0
10:100481584-100481584 C>A	0.0	4158	COLORECTAL	-	-	-	-	HPSE2	ENST00000404542,p.E150D|uc009xwd.2,p.E150D|NM_001166245,p.E150D	protein_coding	uc009xwd.2	nonsynonymous SNV	exon3	c.G450T	p.E150D	PGPDYYLKNYEDEPNNYRTMHGRAV	PGPDYYLKNYEDDPNNYRTMHGRAV	2.0	7.0	-	-	4158_10:100481584-100481584 C>A_PGPDYYLKNYEDDPNNYRTMHGRAV	0.0
13:114762201-114762201 G>C	1.0	4284	COLORECTAL	-	-	-	-	RASA3	ENST00000334062,p.I649M|ENST00000389544,p.I617M|uc001vuj.3,p.I266M|uc001vui.3,p.I649M|NM_007368,p.I649M|uc010tkk.2,p.I617M	protein_coding	uc010tkk.2	nonsynonymous SNV	exon21	c.C1851G	p.I617M	EESFKMKNMFQVIQPERALYIQANN	EESFKMKNMFQVMQPERALYIQANN	8.0	6.0	-	-	4284_13:114762201-114762201 G>C_EESFKMKNMFQVMQPERALYIQANN	0.0
7:77408022-77408022 A>G	1.0	4258	ENDOMETRIAL	-	-	-	-	RSBN1L	ENST00000441514,p.I164M	retained_intron, protein_coding	ENST00000441514	nonsynonymous SNV	exon4	c.A492G	p.I164M	CMQFSMAYSAQIISLRGGHFSEYSY	CMQFSMAYSAQIMSLRGGHFSEYSY	8.0	4.0	-	-	4258_7:77408022-77408022 A>G_CMQFSMAYSAQIMSLRGGHFSEYSY	0.0
X:140995685-140995685 G>T	0.0	4316	COLORECTAL	-	-	-	-	MAGEC1	NM_005462,p.S832I|ENST00000285879,p.S832I|uc022cfi.1,p.S491I|uc004fbt.3,p.S832I	protein_coding	uc022cfi.1	nonsynonymous SNV	exon1	c.G1472T	p.S491I	STSSSLSQSSPVSSFPSSTSSSLSK	STSSSLSQSSPVISFPSSTSSSLSK	1.0	6.0	-	-	4316_X:140995685-140995685 G>T_STSSSLSQSSPVISFPSSTSSSLSK	0.0
5:52225500-52225500 G>A	1.0	3879	MELANOMA	-	-	-	-	ITGA1	ENST00000282588,p.E914K|NM_181501,p.E914K|uc003jow.3,p.E445K|uc003jou.3,p.E914K	retained_intron, protein_coding, processed_transcript	uc003jow.3	nonsynonymous SNV	exon10	c.G1333A	p.E445K	KILFQFNTSYLMENVTIYLSATSDS	KILFQFNTSYLMKNVTIYLSATSDS	9.0	5.0	-	-	3879_5:52225500-52225500 G>A_KILFQFNTSYLMKNVTIYLSATSDS	0.0
16:75446453-75446453 G>A	1.0	3919	MELANOMA	-	-	-	-	CFDP1	NM_006324,p.P128S|uc002fdy.3,p.P128S|uc002fea.1,p.P128S|ENST00000283882,p.P128S|uc002fdz.3,p.P42S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002fea.1	nonsynonymous SNV	exon3	c.C382T	p.P128S	SFLNDVGPKSKVPPSTQVKKGEETE	SFLNDVGPKSKVSPSTQVKKGEETE	8.0	7.0	CD8	-	3919_16:75446453-75446453 G>A_SFLNDVGPKSKVSPSTQVKKGEETE	2.0
2:1982953-1982953 A>G	0.0	4246	COLORECTAL	-	-	-	-	MYT1L	ENST00000428368,p.Y46H|ENST00000399161,p.Y46H|uc002qxd.3,p.Y46H|NM_015025,p.Y46H|uc002qxe.3,p.Y46H	retained_intron, protein_coding, processed_transcript	uc002qxe.3	nonsynonymous SNV	exon8	c.T136C	p.Y46H	PGCDGSGHVSGKYARHRSVYGCPLA	PGCDGSGHVSGKHARHRSVYGCPLA	4.0	3.0	-	-	4246_2:1982953-1982953 A>G_PGCDGSGHVSGKHARHRSVYGCPLA	0.0
3:194313778-194313778 A>T	0.0	4335	COLORECTAL	-	-	-	-	TMEM44	ENST00000432352,p.S159T|ENST00000273580,p.S401T|uc021xjc.1,p.S133T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xjc.1	nonsynonymous SNV	exon5	c.T397A	p.S133T	SDLEQKYWEALNSEQWDPEDVNLEG	SDLEQKYWEALNTEQWDPEDVNLEG	6.0	1.0	-	-	4335_3:194313778-194313778 A>T_SDLEQKYWEALNTEQWDPEDVNLEG	0.0
11:31086577-31086577 A>C	0.0	4238	COLORECTAL	-	-	ID=COSM1269902;OCCURENCE=1(oesophagus)	-	DCDC5,DCDC1	uc009yjk.1,p.L256V|ENST00000597505,p.L808V|uc009yjl.1,p.L184V|uc001msu.2,p.L427V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009yjl.1	nonsynonymous SNV	exon9	c.T550G	p.L184V	AWTTAHQEHGRNLAEEVLQESASNL	AWTTAHQEHGRNVAEEVLQESASNL	2.0	8.0	-	-	4238_11:31086577-31086577 A>C_AWTTAHQEHGRNVAEEVLQESASNL	0.0
20:44511429-44511429 C>G	1.0	3795	MELANOMA	-	-	-	-	ZSWIM1	ENST00000372520,p.C66W|uc010ghi.3,p.C66W|NM_080603,p.C66W|ENST00000372523,p.C66W|uc021wem.1,p.C66W	protein_coding	uc021wem.1	nonsynonymous SNV	exon1	c.C198G	p.C66W	KTAQLDTFNYQSCFMQSVFDHFPEI	KTAQLDTFNYQSWFMQSVFDHFPEI	6.0	2.0	-	-	3795_20:44511429-44511429 C>G_KTAQLDTFNYQSWFMQSVFDHFPEI	0.0
16:701042-701042 C>T	1.0	4000	MELANOMA	-	-	-	-	WDR90	uc002cii.1,p.R203W|uc002cih.1,p.R203W|uc002cig.1,p.R203W|ENST00000549091,p.R203W|ENST00000293879,p.R203W|NM_145294,p.R203W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002cii.1	nonsynonymous SNV	exon6	c.C607T	p.R203W	AQWAKLPVTPMPREMAFPVPKGESW	AQWAKLPVTPMPWEMAFPVPKGESW	7.0	5.0	-	-	4000_16:701042-701042 C>T_AQWAKLPVTPMPWEMAFPVPKGESW	0.0
6:106649928-106649928 G>A	1.0	3713	MELANOMA	-	-	-	-	ATG5	uc031spi.1,p.R204C|ENST00000343245,p.R204C|NM_001286106,p.R204C|NM_001286107,p.R126C|uc003prf.3,p.R204C|uc003prg.3,p.R126C|ENST00000369070,p.R126C|ENST00000369076,p.R204C|NM_004849,p.R204C	protein_coding, processed_transcript	uc031spi.1	nonsynonymous SNV	exon7	c.C610T	p.R204C	TTTERPFIQKLFRPVAADGQLHTLG	TTTERPFIQKLFCPVAADGQLHTLG	5.0	6.0	-	-	3713_6:106649928-106649928 G>A_TTTERPFIQKLFCPVAADGQLHTLG	0.0
X:41204458-41204458 C>-, X:41204454-41204455 TG>-	0.0	4189	MELANOMA	-	-	-	1	DDX3X	NM_001193417,p.R335fs|uc011mkq.2,p.R335fs|uc004dff.3,p.R351fs|ENST00000399959,p.R351fs|NM_001356,p.R351fs|uc004dfe.3,p.R351fs|ENST00000457138,p.R335fs|NM_001193416,p.R351fs|uc011mkr.2,p.R351fs	protein_coding, processed_transcript	uc011mkr.2	frameshift deletion	exon11	c.1051delC	p.R351fs	GLDFCKYLVLDEADRMLDMGFEPQI	GLDFCKYLVLDEAWMLDMGFEPQIRR	10.0	10.0	CD8	fs, fs PR	4189_X:41204458-41204458 C>-, X:41204454-41204455 TG>-_GLDFCKYLVLDEAWMLDMGFEPQIRR	1.0
7:104746043-104746043 C>T	1.0	4071	COLORECTAL	-	-	-	-	KMT2E	ENST00000334884,p.S785F|NM_182931,p.S785F|ENST00000334877,p.S785F|uc003vcm.3,p.S785F|NM_018682,p.S785F|ENST00000257745,p.S785F|uc031syt.1,p.S785F|ENST00000311117,p.S785F|uc010ljc.3,p.S785F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031syt.1	nonsynonymous SNV	exon16	c.C2354T	p.S785F	SLPGLTYSPHVYSTPKHYIRFTSPF	SLPGLTYSPHVYFTPKHYIRFTSPF	10.0	10.0	-	-	4071_7:104746043-104746043 C>T_SLPGLTYSPHVYFTPKHYIRFTSPF	0.0
6:31778497-31778497 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM3783977;OCCURENCE=1(prostate)	-	HSPA1L	NM_005527,p.R418H|uc021yuz.1,p.R418H|ENST00000375654,p.R418H|uc003nxh.3,p.R418H|uc010jte.3,p.R418H|ENST00000417199,p.R418H	protein_coding	uc021yuz.1	nonsynonymous SNV	exon1	c.G1253A	p.R418H	ETAGGVMTALIKRNSTIPTKQTQIF	ETAGGVMTALIKHNSTIPTKQTQIF	7.0	3.0	-	-	4196_6:31778497-31778497 C>T_ETAGGVMTALIKHNSTIPTKQTQIF	0.0
1:223176829-223176829 C>T	0.0	4077	BILE DUCT	-	-	-	-	DISP1	NM_032890,p.A697V|uc001hnu.2,p.A697V|ENST00000284476,p.A697V	protein_coding, processed_transcript	uc001hnu.2	nonsynonymous SNV	exon10	c.C2090T	p.A697V	TVACQKCHKVLFAISEASRIFFEKV	TVACQKCHKVLFVISEASRIFFEKV	5.0	2.0	-	-	4077_1:223176829-223176829 C>T_TVACQKCHKVLFVISEASRIFFEKV	0.0
6:159655394-159655394 C>T	0.0	4246	COLORECTAL	-	-	-	-	FNDC1	uc010kjv.3,p.R1284C|NM_032532,p.R1284C|ENST00000297267,p.R1284C|uc010kjw.1,p.R1169C|ENST00000340366,p.R1221C	protein_coding, processed_transcript	uc010kjw.1	nonsynonymous SNV	exon9	c.C3505T	p.R1169C	VAGTHPWPQYTTRAPPGHFSTTPML	VAGTHPWPQYTTCAPPGHFSTTPML	2.0	9.0	-	-	4246_6:159655394-159655394 C>T_VAGTHPWPQYTTCAPPGHFSTTPML	0.0
12:10462056-10462056 C>T	0.0	4252	COLORECTAL	0.0005	-	ID=COSM3687909;OCCURENCE=1(large_intestine)	-	KLRD1	uc001qxw.4,p.T26M|uc001qxx.4,p.T26M|NM_001114396,p.T26M|NM_002262,p.T26M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001qxx.4	nonsynonymous SNV	exon2	c.C77T	p.T26M	GTLGIICLSLMATLGILLKNSFTKL	GTLGIICLSLMAMLGILLKNSFTKL	6.0	7.0	-	-	4252_12:10462056-10462056 C>T_GTLGIICLSLMAMLGILLKNSFTKL	0.0
5:167857154-167857154 G>T	1.0	4095	COLORECTAL	-	-	-	-	WWC1	ENST00000521089,p.K671N|uc011den.2,p.K671N|uc003lzu.3,p.K671N|ENST00000265293,p.K671N|uc003lzv.3,p.K671N|NM_001161662,p.K671N|NM_001161661,p.K671N|uc003lzw.3,p.K470N|NM_015238,p.K671N	retained_intron, protein_coding, processed_transcript, TEC	uc011den.2	nonsynonymous SNV	exon14	c.G2013T	p.K671N	ATRIQIALKYDEKNKQFAILIIQLS	ATRIQIALKYDENNKQFAILIIQLS	8.0	8.0	-	-	4095_5:167857154-167857154 G>T_ATRIQIALKYDENNKQFAILIIQLS	0.0
5:140774045-140774045 G>C	0.0	4240	BREAST	-	-	-	-	PCDHGA8	NM_014004,p.Q555H|NM_032088,p.Q555H|uc003lkb.4,p.Q555H|ENST00000398604,p.Q555H|uc003lkd.2,p.Q555H	protein_coding	uc003lkd.2	nonsynonymous SNV	exon1	c.G1665C	p.Q555H	SSNMSLSLFVLDQNDNAPEILYPAL	SSNMSLSLFVLDHNDNAPEILYPAL	4.0	2.0	-	-	4240_5:140774045-140774045 G>C_SSNMSLSLFVLDHNDNAPEILYPAL	0.0
16:68042-68042 C>T	1.0	4326	BREAST	-	rs76638931	-	-	MIR6859-1,MIR6859-2	ENST00000326592,p.R72Q|uc002cfg.1,p.R72Q	retained_intron, protein_coding, nonsense_mediated_decay	uc002cfg.1	nonsynonymous SNV	exon2	c.G215A	p.R72Q	DGSRISQQVEQSRSQVQAIGEKVSL	DGSRISQQVEQSQSQVQAIGEKVSL	10.0	2.0	-	-	4326_16:68042-68042 C>T_DGSRISQQVEQSQSQVQAIGEKVSL	0.0
14:94776154-94776154 G>A	0.0	4235	COLORECTAL	-	-	-	-	SERPINA6	uc001ycv.3,p.P268L|ENST00000341584,p.P268L|NM_001756,p.P268L	protein_coding, nonsense_mediated_decay	uc001ycv.3	nonsynonymous SNV	exon3	c.C803T	p.P268L	NYVGNGTVFFILPDKGKMNTVIAAL	NYVGNGTVFFILLDKGKMNTVIAAL	4.0	9.0	-	-	4235_14:94776154-94776154 G>A_NYVGNGTVFFILLDKGKMNTVIAAL	0.0
6:121625511-121625511 T>G	0.0	4345	COLORECTAL	-	-	-	-	TBC1D32	ENST00000275159,p.K312T|uc003pyo.1,p.K312T|ENST00000398212,p.K312T|NM_152730,p.K312T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003pyo.1	nonsynonymous SNV	exon8	c.A935C	p.K312T	KEAPSFWIRHPEKYMEEIVESTLSL	KEAPSFWIRHPETYMEEIVESTLSL	6.0	6.0	-	-	4345_6:121625511-121625511 T>G_KEAPSFWIRHPETYMEEIVESTLSL	0.0
9:118997664-118997664 C>T	1.0	3713	MELANOMA	-	-	-	-	PAPPA	ENST00000328252,p.S827F|NM_002581,p.S827F|uc011lxp.1,p.S522F|uc004bjn.3,p.S827F	protein_coding, processed_transcript	uc011lxp.1	nonsynonymous SNV	exon5	c.C1565T	p.S522F	DIKLLAVSGKNISLGPQNVFCDVPL	DIKLLAVSGKNIFLGPQNVFCDVPL	1.0	3.0	-	-	3713_9:118997664-118997664 C>T_DIKLLAVSGKNIFLGPQNVFCDVPL	0.0
4:2515425-2515425 C>T	1.0	3713	MELANOMA	-	-	-	-	RNF4	ENST00000541204,p.S151F|ENST00000314289,p.S151F|uc003gfb.3,p.S151F|NM_002938,p.S151F|ENST00000502316,p.S151F|NM_001185009,p.S151F|ENST00000511600,p.S151F|ENST00000506706,p.S151F|uc003gfc.3,p.S151F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gfc.3	nonsynonymous SNV	exon9	c.C452T	p.S151F	YSEIVQNGRLIVSTECGHVFCSQCL	YSEIVQNGRLIVFTECGHVFCSQCL	8.0	5.0	-	-	3713_4:2515425-2515425 C>T_YSEIVQNGRLIVFTECGHVFCSQCL	0.0
19:40541834-40541834 T>G	1.0	4320	COLORECTAL	-	-	-	-	ZNF780B	uc002omu.3,p.E311A|ENST00000221355,p.E163A|uc002omv.3,p.E163A|ENST00000434248,p.E311A|NM_001005851,p.E311A	retained_intron, protein_coding, non_stop_decay	uc002omv.3	nonsynonymous SNV	exon6	c.A488C	p.E163A	HSNEKPFVCRECEMAFRYHYQLIEH	HSNEKPFVCRECAMAFRYHYQLIEH	9.0	5.0	-	-	4320_19:40541834-40541834 T>G_HSNEKPFVCRECAMAFRYHYQLIEH	0.0
4:88903647-88903647 C>T	1.0	3879	MELANOMA	-	-	-	-	SPP1	ENST00000395080,p.P182S|NM_001251830,p.P195S|ENST00000237623,p.P168S|uc003hrc.3,p.P168S|NM_001040060,p.P155S|NM_001251829,p.P141S|uc003hrd.3,p.P141S|uc011cde.2,p.P195S|NM_001040058,p.P182S|uc003hrb.3,p.P155S|NM_000582,p.P168S|ENST00000508233,p.P141S|ENST00000360804,p.P155S|uc003hra.3,p.P182S	retained_intron, protein_coding, processed_transcript	uc011cde.2	nonsynonymous SNV	exon8	c.C583T	p.P195S	KSKKFRRPDIQYPDATDEDITSHME	KSKKFRRPDIQYSDATDEDITSHME	10.0	3.0	-	-	3879_4:88903647-88903647 C>T_KSKKFRRPDIQYSDATDEDITSHME	0.0
21:46888426-46888426 C>T	1.0	3466	MELANOMA	-	-	-	-	COL18A1	uc002zhi.3,p.S306F|uc002zhg.3,p.S126F|ENST00000355480,p.S306F|ENST00000359759,p.S541F|NM_130445,p.S126F|NM_030582,p.S306F|ENST00000400337,p.S126F	retained_intron, protein_coding, processed_transcript	uc002zhi.3	nonsynonymous SNV	exon2	c.C917T	p.S306F	SAQAMVLLGVKLSGVQDGHQDISLL	SAQAMVLLGVKLFGVQDGHQDISLL	9.0	1.0	CD8	-	3466_21:46888426-46888426 C>T_SAQAMVLLGVKLFGVQDGHQDISLL	1.0
1:200586800-200586800 G>A	1.0	3919	MELANOMA	-	-	-	-	KIF14	ENST00000367350,p.P351L|uc010ppk.1,p.P351L|NM_014875,p.P351L	protein_coding	uc010ppk.1	nonsynonymous SNV	exon2	c.C1052T	p.P351L	ETVVQNTSAGKDPLKVENSQVTVAV	ETVVQNTSAGKDLLKVENSQVTVAV	5.0	6.0	-	-	3919_1:200586800-200586800 G>A_ETVVQNTSAGKDLLKVENSQVTVAV	0.0
9:97912215-97912215 C>T	1.0	3903	MELANOMA	-	-	-	1	FANCC	NM_000136,p.A226T|uc022bkl.1,p.A226T|ENST00000375305,p.A226T|NM_001243744,p.A226T|uc004avh.3,p.A226T|NM_001243743,p.A226T|uc004avi.4,p.A226T|ENST00000289081,p.A226T	protein_coding, processed_transcript	uc022bkl.1	nonsynonymous SNV	exon7	c.G676A	p.A226T	ILQPEFFEAVNEAILLKKISLPMSA	ILQPEFFEAVNETILLKKISLPMSA	6.0	10.0	-	-	3903_9:97912215-97912215 C>T_ILQPEFFEAVNETILLKKISLPMSA	0.0
19:45532197-45532197 G>A	1.0	3713	MELANOMA	-	-	-	-	RELB	ENST00000505236,p.G310E|ENST00000221452,p.G313E|ENST00000540120,p.G313E|uc021uvq.1,p.G313E	retained_intron, protein_coding, nonsense_mediated_decay	uc021uvq.1	nonsynonymous SNV	exon8	c.G938A	p.G313E	SELRICRINKESGPCTGGEELYLLC	SELRICRINKESEPCTGGEELYLLC	3.0	10.0	-	-	3713_19:45532197-45532197 G>A_SELRICRINKESEPCTGGEELYLLC	0.0
14:72190414-72190414 G>A	1.0	4180	BREAST	-	-	-	-	SIPA1L1	uc001xms.3,p.R1441Q|uc001xmv.3,p.R1441Q|ENST00000555818,p.R1441Q|uc001xmt.3,p.R1420Q|uc001xmu.3,p.R1420Q|NM_015556,p.R1441Q|NM_001284245,p.R1420Q|ENST00000381232,p.R1420Q|uc010ttm.2,p.R895Q|NM_001284246,p.R1420Q|ENST00000358550,p.R1420Q|NM_001284247,p.R1441Q|ENST00000537413,p.R895Q	retained_intron, protein_coding, processed_transcript	uc010ttm.2	nonsynonymous SNV	exon14	c.G2684A	p.R895Q	RHSASPVVFTSARSSPKEELHPAAP	RHSASPVVFTSAQSSPKEELHPAAP	8.0	10.0	-	-	4180_14:72190414-72190414 G>A_RHSASPVVFTSAQSSPKEELHPAAP	0.0
7:123593799-123593799 T>-	0.0	4246	COLORECTAL	-	-	-	-	SPAM1	uc003vle.3,p.F59fs|NM_001174044,p.F59fs|ENST00000340011,p.F59fs|NM_001174045,p.F59fs|uc022aks.1,p.F59fs|uc010lku.3,p.F59fs|NM_003117,p.F59fs|NM_001174046,p.F59fs|ENST00000402183,p.F59fs|ENST00000439500,p.F59fs|uc003vld.3,p.F59fs|ENST00000413927,p.F59fs|ENST00000460182,p.F59fs|uc003vlf.4,p.F59fs|ENST00000223028,p.F59fs|NM_153189,p.F59fs	protein_coding	uc022aks.1	frameshift deletion	exon3	c.175delT	p.F59fs	VPFLWAWNAPSEFCLGKFDEPLDMS	VPFLWAWNAPSEFVLENLMSH	1.0	5.0	-	-	4246_7:123593799-123593799 T>-_VPFLWAWNAPSEFVLENLMSH	0.0
17:7578526-7578526 C>T	1.0	4316	COLORECTAL	-	-	ID=COSM99600,COSM2744946,COSM99599,COSM3691869,COSM10801,COSM99601,COSM99598;OCCURENCE=2(haematopoietic_and_lymphoid_tissue),1(thyroid),4(lung),3(upper_aerodigestive_tract),5(oesophagus),2(central_nervous_system),1(stomach),4(urinary_tract),2(liver),1(pancreas),1(prostate),10(large_intestine),1(skin),9(breast),1(autonomic_ganglia),8(ovary)	1	TP53	ENST00000514944,p.C42Y|uc002gin.3,p.C42Y	retained_intron, protein_coding, processed_transcript	uc002gin.3	nonsynonymous SNV	exon4	c.G125A	p.C42Y	NVLYSPALNKMFCQLAKTCPVQLWV	NVLYSPALNKMFYQLAKTCPVQLWV	9.0	10.0	-	-	4316_17:7578526-7578526 C>T_NVLYSPALNKMFYQLAKTCPVQLWV	0.0
17:26961102-26961102 G>A	1.0	2369	MELANOMA	-	-	-	-	KIAA0100	ENST00000389003,p.R882W|NM_014680,p.R1025W|ENST00000544884,p.R882W|uc002hbu.3,p.R1025W|ENST00000528896,p.R1025W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hbu.3	nonsynonymous SNV	exon17	c.C3073T	p.R1025W	RMLKCNVKSFLVRIRDYPRYLFEIR	RMLKCNVKSFLVWIRDYPRYLFEIR	10.0	7.0	-	-	2369_17:26961102-26961102 G>A_RMLKCNVKSFLVWIRDYPRYLFEIR	0.0
19:51021213-51021213 G>C	0.0	4326	BREAST	-	-	-	-	LRRC4B	uc002pss.3,p.T586R|ENST00000599957,p.T586R|NM_001080457,p.T586R|ENST00000389201,p.T586R	protein_coding	uc002pss.3	nonsynonymous SNV	exon3	c.C1757G	p.T586R	TTKIIIGCFVAITFMAAVMLVAFYK	TTKIIIGCFVAIRFMAAVMLVAFYK	4.0	1.0	-	-	4326_19:51021213-51021213 G>C_TTKIIIGCFVAIRFMAAVMLVAFYK	0.0
17:74307645-74307645 C>T	1.0	4252	COLORECTAL	-	-	-	-	PRPSAP1	ENST00000324684,p.R276Q|uc010wta.1,p.R379Q|uc010wtb.1,p.R276Q|ENST00000446526,p.R379Q|NM_002766,p.R379Q	retained_intron, protein_coding, processed_transcript	uc010wtb.1	nonsynonymous SNV	exon10	c.G827A	p.R276Q	RIHNGESMAYLFRNITVDD	RIHNGESMAYLFQNITVDD	9.0	10.0	-	-	4252_17:74307645-74307645 C>T_RIHNGESMAYLFQNITVDD	0.0
1:157497542-157497542 T>C	0.0	4287	COLORECTAL	-	-	-	-	FCRL5	uc010phw.1,p.S524G|ENST00000356953,p.S609G|NM_001195388,p.S609G|uc010phv.1,p.S609G|NM_031281,p.S609G|uc009wsm.3,p.S609G|ENST00000368191,p.S524G|uc001fqu.3,p.S609G|ENST00000361835,p.S609G|ENST00000368190,p.S609G	protein_coding, processed_transcript	uc010phw.1	nonsynonymous SNV	exon8	c.A1570G	p.S524G	LYWFYHEDVTLGSSSAPSGGEASFN	LYWFYHEDVTLGGSSAPSGGEASFN	5.0	9.0	-	-	4287_1:157497542-157497542 T>C_LYWFYHEDVTLGGSSAPSGGEASFN	0.0
16:24573203-24573203 C>G	1.0	4186	BREAST	-	-	-	-	RBBP6	uc002dmi.3,p.P337R|NM_006910,p.P337R|ENST00000564314,p.P204R|uc010vcb.1,p.P204R|ENST00000381039,p.P337R|uc002dmk.3,p.P204R|uc002dmh.3,p.P337R|ENST00000319715,p.P337R|ENST00000348022,p.P337R|uc010bxr.3,p.P337R|NM_018703,p.P337R	retained_intron, protein_coding	uc010vcb.1	nonsynonymous SNV	exon8	c.C611G	p.P204R	ETGYTKRLRKQLPPPPPPIPPPRPL	ETGYTKRLRKQLRPPPPPIPPPRPL	9.0	1.0	-	-	4186_16:24573203-24573203 C>G_ETGYTKRLRKQLRPPPPPIPPPRPL	0.0
2:60773289-60773289 G>A	0.0	4258	ENDOMETRIAL	-	-	-	1	BCL11A	ENST00000358510,p.R68W|uc010ypj.2,p.R68W|uc002sae.1,p.R68W|ENST00000335712,p.R68W|uc010fcg.3,p.R68W|uc002saf.1,p.R68W|NM_138559,p.R68W|ENST00000359629,p.R68W|uc002sab.3,p.R68W|NM_018014,p.R68W|ENST00000538214,p.R68W|uc002sac.3,p.R68W|ENST00000356842,p.R68W|NM_022893,p.R68W	protein_coding, processed_transcript	uc010ypj.2	nonsynonymous SNV	exon2	c.C202T	p.R68W	PLGDILIFIEHKRKQCNGSLCLEKA	PLGDILIFIEHKWKQCNGSLCLEKA	5.0	10.0	-	-	4258_2:60773289-60773289 G>A_PLGDILIFIEHKWKQCNGSLCLEKA	0.0
10:55663094-55663094 T>C	0.0	4160	COLORECTAL	-	-	-	-	PCDH15	uc021pqw.1,p.E1149G|uc010qhw.1,p.E1100G|uc021pqv.1,p.E1137G|uc021pqz.1,p.E1115G|ENST00000395432,p.E1100G|NM_001142768,p.E1115G|NM_001142764,p.E1137G|uc010qib.1,p.E1115G|ENST00000373965,p.E1144G|uc021pqy.1,p.E1137G|ENST00000395438,p.E1137G|ENST00000395445,p.E1144G|ENST00000395430,p.E1137G|ENST00000409834,p.E748G|uc010qht.2,p.E1144G|uc010qhq.2,p.E1142G|NM_033056,p.E1137G|uc010qhr.2,p.E1137G|NM_001142763,p.E1142G|uc021pqx.1,p.E1137G|NM_001142765,p.E1066G|NM_001142773,p.E1115G|uc010qhx.1,p.E1066G|uc010qhy.1,p.E1142G|ENST00000437009,p.E1066G|uc010qhv.1,p.E1137G|ENST00000361849,p.E1137G|NM_001142767,p.E1100G|uc010qhz.1,p.E1137G|ENST00000395433,p.E1115G|ENST00000320301,p.E1137G|uc010qia.1,p.E1115G|NM_001142766,p.E1137G|uc001jju.1,p.E1137G|ENST00000414778,p.E1142G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pqz.1	nonsynonymous SNV	exon24	c.A3344G	p.E1115G	SNTAKVYIEIQDENNHPPVFQKKFY	SNTAKVYIEIQDGNNHPPVFQKKFY	1.0	4.0	-	-	4160_10:55663094-55663094 T>C_SNTAKVYIEIQDGNNHPPVFQKKFY	0.0
X:70609435-70609435 G>A	0.0	4301	MELANOMA	-	-	-	-	TAF1	uc004dzv.4,p.D74N|NM_001286074,p.D921N|uc004dzt.4,p.D921N|uc004dzu.4,p.D900N|ENST00000373790,p.D900N|ENST00000276072,p.D921N|NM_004606,p.D921N|ENST00000449580,p.D900N|ENST00000423759,p.D921N|NM_138923,p.D900N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004dzv.4	nonsynonymous SNV	exon3	c.G220A	p.D74N	YYSMIAAEQRLKDAGYGEKSFFAPE	YYSMIAAEQRLKNAGYGEKSFFAPE	8.0	1.0	-	-	4301_X:70609435-70609435 G>A_YYSMIAAEQRLKNAGYGEKSFFAPE	0.0
15:56388408-56388408 C>A	1.0	4316	COLORECTAL	-	-	-	-	RFX7	uc002adn.1,p.R320S|NM_022841,p.R506S|uc010bfn.3,p.R506S|ENST00000317318,p.R506S|ENST00000559447,p.R409S|ENST00000422057,p.R409S|ENST00000423270,p.R506S|ENST00000559847,p.R409S	protein_coding, nonsense_mediated_decay	uc010bfn.3	nonsynonymous SNV	exon9	c.G1518T	p.R506S	SVSSATGTTEESRSVPQIKNGSVVS	SVSSATGTTEESSSVPQIKNGSVVS	5.0	1.0	-	-	4316_15:56388408-56388408 C>A_SVSSATGTTEESSSVPQIKNGSVVS	0.0
17:65907511-65907511 T>A	1.0	4189	MELANOMA	-	-	-	-	BPTF	uc002jge.3,p.S1297T|ENST00000544778,p.S1234T|ENST00000424123,p.S1158T|uc002jgf.3,p.S1171T|NM_004459,p.S1297T|ENST00000335221,p.S1297T|ENST00000321892,p.S1297T|ENST00000306378,p.S1171T|NM_182641,p.S1171T	retained_intron, protein_coding, processed_transcript	uc002jgf.3	nonsynonymous SNV	exon11	c.T3511A	p.S1171T	KLYPKDRVLDDVSIRSPETKCPKQN	KLYPKDRVLDDVTIRSPETKCPKQN	10.0	1.0	-	-	4189_17:65907511-65907511 T>A_KLYPKDRVLDDVTIRSPETKCPKQN	0.0
2:141356285-141356285 A>C	0.0	4160	COLORECTAL	-	-	-	1	LRP1B	NM_018557,p.I2370S|uc002tvj.1,p.I2370S|ENST00000389484,p.I2370S	protein_coding, processed_transcript	uc002tvj.1	nonsynonymous SNV	exon43	c.T7109G	p.I2370S	VSTDILTPNGLTIDYRAEKLYFSDG	VSTDILTPNGLTSDYRAEKLYFSDG	2.0	5.0	-	-	4160_2:141356285-141356285 A>C_VSTDILTPNGLTSDYRAEKLYFSDG	0.0
22:22869267-22869267 C>T	1.0	2369	MELANOMA	-	-	-	-	ZNF280A	uc002zwe.3,p.D230N|ENST00000302097,p.D230N|NM_080740,p.D230N|uc021wmo.1,p.D230N	protein_coding	uc021wmo.1	nonsynonymous SNV	exon1	c.G688A	p.D230N	NHVQNGVTFPWPDANGKAHFNLTDP	NHVQNGVTFPWPNANGKAHFNLTDP	7.0	8.0	-	-	2369_22:22869267-22869267 C>T_NHVQNGVTFPWPNANGKAHFNLTDP	0.0
21:37418206-37418206 G>A	1.0	3713	MELANOMA	-	-	-	-	SETD4	NM_001007261,p.P110S|ENST00000399212,p.P110S|ENST00000399207,p.P134S|uc002yux.2,p.P110S|uc002yuz.3,p.P110S|ENST00000332131,p.P134S|uc021wiy.1,p.P134S|uc002yuy.3,p.P134S|NM_017438,p.P134S|ENST00000399215,p.P134S|ENST00000446166,p.P110S|ENST00000429161,p.P134S|uc002yuw.2,p.P134S|NM_001007259,p.P134S|ENST00000424303,p.P134S|ENST00000399205,p.P110S|uc002yva.3,p.P110S|ENST00000399208,p.P134S|ENST00000399201,p.P110S|NM_001286752,p.P110S	retained_intron, protein_coding, processed_transcript	uc021wiy.1	nonsynonymous SNV	exon6	c.C400T	p.P134S	HRSLWKPYLEILPKAYTCPVCLEPE	HRSLWKPYLEILSKAYTCPVCLEPE	8.0	9.0	-	-	3713_21:37418206-37418206 G>A_HRSLWKPYLEILSKAYTCPVCLEPE	0.0
5:140626743-140626743 G>A	0.0	4078	GASTRIC	-	-	-	-	PCDHB15	NM_018935,p.A533T|ENST00000231173,p.A533T|uc003lje.3,p.A533T	protein_coding	uc003lje.3	nonsynonymous SNV	exon1	c.G1597A	p.A533T	YEALQAFEFRVGATDRGFPALSSEA	YEALQAFEFRVGTTDRGFPALSSEA	3.0	10.0	-	-	4078_5:140626743-140626743 G>A_YEALQAFEFRVGTTDRGFPALSSEA	0.0
9:420960-420960 T>G	0.0	4335	COLORECTAL	-	-	-	-	DOCK8	ENST00000382329,p.S812R|NM_001193536,p.S1277R|ENST00000432829,p.S1277R|ENST00000469391,p.S1245R|uc010mgu.3,p.S647R|uc022bcu.1,p.S1277R|uc003zgf.2,p.S1345R|ENST00000453981,p.S1345R|uc010mgv.3,p.S1245R|uc003zgk.2,p.S803R|NM_203447,p.S1345R|NM_001190458,p.S1245R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022bcu.1	nonsynonymous SNV	exon31	c.T3831G	p.S1277R	ICVLCFEYKGKQSSDKVSTQVLQKS	ICVLCFEYKGKQRSDKVSTQVLQKS	10.0	1.0	-	-	4335_9:420960-420960 T>G_ICVLCFEYKGKQRSDKVSTQVLQKS	0.0
6:41655673-41655673 C>T	1.0	2556	MELANOMA	-	-	-	1	TFEB	NM_001271945,p.D215N|ENST00000419396,p.D215N|ENST00000394283,p.D215N|ENST00000420312,p.D130N|uc010jxo.1,p.D215N|NM_007162,p.D215N|uc003oqs.1,p.D215N|ENST00000230323,p.D215N|uc003oqt.2,p.D215N|uc003oqu.2,p.D229N|NM_001271944,p.D215N|NM_001167827,p.D229N|uc021yzl.1,p.D282N|ENST00000358871,p.D229N|uc031sop.1,p.D215N|ENST00000416140,p.D215N|ENST00000343317,p.D301N|ENST00000403298,p.D215N|uc003oqr.2,p.D130N|ENST00000406563,p.D73N|uc003oqv.1,p.D215N|ENST00000373033,p.D215N|NM_001271943,p.D130N	retained_intron, protein_coding	uc031sop.1	nonsynonymous SNV	exon5	c.G643A	p.D215N	SLVGVTSSSCPADLTQKRELTDAES	SLVGVTSSSCPANLTQKRELTDAES	5.0	5.0	-	-	2556_6:41655673-41655673 C>T_SLVGVTSSSCPANLTQKRELTDAES	0.0
12:81239651-81239651 G>A	0.0	4196	COLORECTAL	-	-	-	-	LIN7A	NM_004664,p.T114I|ENST00000549417,p.T108I|uc001szj.1,p.T114I|ENST00000552864,p.T114I	protein_coding, nonsense_mediated_decay	uc001szj.1	nonsynonymous SNV	exon4	c.C341T	p.T114I	GHSHPRVVELPKTDEGLGFNVMGGK	GHSHPRVVELPKIDEGLGFNVMGGK	6.0	5.0	-	-	4196_12:81239651-81239651 G>A_GHSHPRVVELPKIDEGLGFNVMGGK	0.0
14:61446227-61446227 G>A	1.0	4298	COLORECTAL	-	-	-	-	TRMT5	uc001xff.4,p.P130L|ENST00000261249,p.P130L|NM_020810,p.P130L	protein_coding	uc001xff.4	nonsynonymous SNV	exon2	c.C389T	p.P130L	LQRPGIRRVIEDPEDKESRLIMLDP	LQRPGIRRVIEDLEDKESRLIMLDP	6.0	10.0	-	-	4298_14:61446227-61446227 G>A_LQRPGIRRVIEDLEDKESRLIMLDP	0.0
20:61341109-61341109 C>T	0.0	4298	COLORECTAL	-	-	-	-	NTSR1	uc002ydf.3,p.R184C|ENST00000370501,p.R184C|NM_002531,p.R184C	protein_coding, processed_transcript	uc002ydf.3	nonsynonymous SNV	exon1	c.C550T	p.R184C	HPFKAKTLMSRSRTKKFISAIWLAS	HPFKAKTLMSRSCTKKFISAIWLAS	2.0	4.0	-	-	4298_20:61341109-61341109 C>T_HPFKAKTLMSRSCTKKFISAIWLAS	0.0
1:244218580-244218580 G>T	1.0	4213	COLORECTAL	-	-	-	-	ZBTB18	NM_001278196,p.V493L|uc001iae.4,p.V493L|NM_205768,p.V502L|uc001iad.5,p.V502L|NM_006352,p.V493L|uc031psv.1,p.V493L|ENST00000358704,p.V502L	protein_coding	uc031psv.1	nonsynonymous SNV	exon2	c.G1477T	p.V493L	LYRHIRKFHCELVNSLSVKSEALSL	LYRHIRKFHCELLNSLSVKSEALSL	8.0	10.0	-	-	4213_1:244218580-244218580 G>T_LYRHIRKFHCELLNSLSVKSEALSL	0.0
1:148346658-148346658 C>A	1.0	4326	BREAST	-	-	-	-	NBPF14,NBPF8,NBPF9	uc021owp.2,p.Q33H|NM_015383,p.Q33H	protein_coding	uc021owp.2	nonsynonymous SNV	exon1	c.G99T	p.Q33H	NETLRPQLAEKKQQFRNLKEKCFLT	NETLRPQLAEKKHQFRNLKEKCFLT	10.0	7.0	-	-	4326_1:148346658-148346658 C>A_NETLRPQLAEKKHQFRNLKEKCFLT	0.0
22:19349257-19349257 G>A	1.0	4189	MELANOMA	-	-	-	-	HIRA	ENST00000546308,p.S614F|uc010gro.2,p.S614F|uc011agx.1,p.S524F|uc002zpf.1,p.S658F|NM_003325,p.S658F|ENST00000541063,p.S614F|ENST00000263208,p.S658F	protein_coding, processed_transcript, nonsense_mediated_decay	uc011agx.1	nonsynonymous SNV	exon18	c.C1571T	p.S524F	PRKDSRLMPVSLSVQSPAALTAEKE	PRKDSRLMPVSLFVQSPAALTAEKE	8.0	1.0	-	-	4189_22:19349257-19349257 G>A_PRKDSRLMPVSLFVQSPAALTAEKE	0.0
6:56337020-56337020 C>T	1.0	4326	BREAST	-	-	-	-	DST	NM_001144770,p.R5075K|ENST00000244364,p.R4709K|ENST00000361203,p.R7012K|NM_015548,p.R4709K|uc021zaz.2,p.R5035K|ENST00000523943,p.R40K|uc003pcy.4,p.R4709K|ENST00000446842,p.R6797K|ENST00000421834,p.R5035K|NM_183380,p.R5035K|uc021zay.2,p.R5075K|ENST00000370788,p.R4926K|uc021zba.2,p.R5213K|ENST00000370769,p.R7123K|NM_001144769,p.R5213K|ENST00000370754,p.R7301K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zba.2	nonsynonymous SNV	exon88	c.G15638A	p.R5213K	SHIPVLDKGRAGRKRFPASSLYPSG	SHIPVLDKGRAGKKRFPASSLYPSG	8.0	1.0	-	-	4326_6:56337020-56337020 C>T_SHIPVLDKGRAGKKRFPASSLYPSG	0.0
6:159646683-159646683 C>A	0.0	4346	COLORECTAL	-	-	-	-	FNDC1	ENST00000297267,p.A334E|ENST00000340366,p.A334E|uc010kjw.1,p.A282E|uc010kjv.3,p.A334E|NM_032532,p.A334E	protein_coding, processed_transcript	uc010kjw.1	nonsynonymous SNV	exon7	c.C845A	p.A282E	IENLIPDTVYEFAVRISQGERDGKW	IENLIPDTVYEFEVRISQGERDGKW	4.0	4.0	-	-	4346_6:159646683-159646683 C>A_IENLIPDTVYEFEVRISQGERDGKW	0.0
8:21957390-21957390 C>T	1.0	3879	MELANOMA	-	-	-	-	FAM160B2	uc011kyx.2,p.H443Y|ENST00000450006,p.H443Y|ENST00000289921,p.H443Y|NM_022749,p.H443Y	retained_intron, protein_coding, nonsense_mediated_decay	uc011kyx.2	nonsynonymous SNV	exon10	c.C1327T	p.H443Y	HTLYAHLIGHCDHLSDEISITTLRL	HTLYAHLIGHCDYLSDEISITTLRL	9.0	9.0	-	-	3879_8:21957390-21957390 C>T_HTLYAHLIGHCDYLSDEISITTLRL	0.0
11:67203389-67203389 G>A	1.0	4245	COLORECTAL	-	-	-	-	PTPRCAP	uc001oli.1,p.R146W|NM_005608,p.R146W|ENST00000326294,p.R146W	protein_coding	uc001oli.1	nonsynonymous SNV	exon2	c.C436T	p.R146W	CGEASSPEQVPVRAEEARDSDTEGD	CGEASSPEQVPVWAEEARDSDTEGD	9.0	9.0	-	-	4245_11:67203389-67203389 G>A_CGEASSPEQVPVWAEEARDSDTEGD	0.0
2:120831700-120831700 T>C	1.0	4037	NSCLC	-	-	-	-	EPB41L5	NM_020909,p.L118P|uc002tmg.3,p.L118P|ENST00000443902,p.L118P|NM_001184939,p.L118P|NM_001184938,p.L118P|NM_001184937,p.L118P|ENST00000443124,p.L118P|ENST00000452780,p.L118P|ENST00000263713,p.L118P|uc010flk.3,p.L118P|ENST00000331393,p.L118P|uc010fll.3,p.L118P|uc002tmh.4,p.L118P	retained_intron, protein_coding, processed_transcript	uc010fll.3	nonsynonymous SNV	exon5	c.T353C	p.L118P	KQVKIGSPYCLHLRVKFYSSEPNNL	KQVKIGSPYCLHPRVKFYSSEPNNL	8.0	7.0	-	-	4037_2:120831700-120831700 T>C_KQVKIGSPYCLHPRVKFYSSEPNNL	0.0
20:47607733-47607733 G>A	1.0	3713	MELANOMA	-	-	-	-	ARFGEF2	uc010zyf.2,p.E284K|ENST00000371917,p.E991K|uc002xtx.4,p.E991K|NM_006420,p.E991K	protein_coding, processed_transcript	uc010zyf.2	nonsynonymous SNV	exon7	c.G850A	p.E284K	HTDGNYLGNSWHEILKCISQLELAQ	HTDGNYLGNSWHKILKCISQLELAQ	7.0	9.0	-	-	3713_20:47607733-47607733 G>A_HTDGNYLGNSWHKILKCISQLELAQ	0.0
10:120933972-120933972 G>A	1.0	3713	MELANOMA	-	-	-	-	PRDX3	uc021pzp.1,p.P83L|NM_014098,p.P83L|uc001lec.3,p.P101L|ENST00000356951,p.P83L|NM_006793,p.P101L|ENST00000298510,p.P101L	protein_coding, processed_transcript	uc021pzp.1	nonsynonymous SNV	exon3	c.C248T	p.P83L	DFKGKYLVLFFYPLDFTFVCPTEIV	DFKGKYLVLFFYLLDFTFVCPTEIV	8.0	9.0	CD8	-	3713_10:120933972-120933972 G>A_DFKGKYLVLFFYLLDFTFVCPTEIV	1.0
3:178936091-178936091 G>A	1.0	4240	BREAST	-	-	ID=COSM763,COSM125370;OCCURENCE=4(salivary_gland),38(endometrium),4(soft_tissue),28(ovary),1(pituitary),4(kidney),3(pancreas),3(liver),126(urinary_tract),1(biliary_tract),373(large_intestine),1(prostate),365(breast),16(skin),1(small_intestine),41(upper_aerodigestive_tract),8(oesophagus),18(stomach),17(central_nervous_system),21(cervix),7(gastrointestinal_tract_(site_indeterminate)),4(penis),44(lung),7(thyroid)	1	PIK3CA	NM_006218,p.E545K|uc003fjk.3,p.E545K|ENST00000263967,p.E545K	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon10	c.G1633A	p.E545K	AISTRDPLSEITEQEKDFLWSHRHY	AISTRDPLSEITKQEKDFLWSHRHY	6.0	10.0	-	-	4240_3:178936091-178936091 G>A_AISTRDPLSEITKQEKDFLWSHRHY	0.0
2:152502698-152502698 C>G	0.0	4258	ENDOMETRIAL	-	-	-	-	NEB	ENST00000603639,p.M2494I|uc002txu.3,p.M2494I|ENST00000427231,p.M2494I|uc021vrc.1,p.M2494I|uc031rpp.1,p.M2494I|ENST00000409198,p.M2494I|NM_001164508,p.M2494I|uc010fnx.3,p.M2494I|uc021vrd.1,p.M2494I|uc021vrb.1,p.M2494I|NM_004543,p.M2494I|ENST00000604864,p.M2494I|NM_001271208,p.M2494I|ENST00000172853,p.M2494I|ENST00000397345,p.M2494I|NM_001164507,p.M2494I	retained_intron, protein_coding, processed_transcript	uc031rpp.1	nonsynonymous SNV	exon55	c.G7482C	p.M2494I	EAWDKDKTQIHIMPDTPDIVLAKAN	EAWDKDKTQIHIIPDTPDIVLAKAN	9.0	10.0	-	-	4258_2:152502698-152502698 C>G_EAWDKDKTQIHIIPDTPDIVLAKAN	0.0
5:112177722-112177722 T>A	1.0	3775	CERVICAL	-	-	-	1	APC	ENST00000257430,p.L2144Q|ENST00000508376,p.L2144Q|uc003kpz.4,p.L2144Q|NM_001127510,p.L2144Q|NM_000038,p.L2144Q|ENST00000457016,p.L2144Q|uc011cvt.2,p.L2126Q|NM_001127511,p.L2126Q|uc003kpy.4,p.L2144Q|uc010jbz.3,p.L1861Q|uc010jca.3,p.L1444Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cvt.2	nonsynonymous SNV	exon14	c.T6377A	p.L2126Q	SDSILSLKSGISLGSPFHLTPDQEE	SDSILSLKSGISQGSPFHLTPDQEE	6.0	8.0	-	-	3775_5:112177722-112177722 T>A_SDSILSLKSGISQGSPFHLTPDQEE	0.0
14:75245382-75245382 C>T	1.0	3466	MELANOMA	-	-	-	-	YLPM1	ENST00000238571,p.P369L|ENST00000325680,p.P369L|NM_019589,p.P369L|uc001xqj.4,p.P369L|ENST00000552421,p.P369L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001xqj.4	nonsynonymous SNV	exon2	c.C1106T	p.P369L	NEEVPPPLPPEEPQSEDPEEDARLK	NEEVPPPLPPEELQSEDPEEDARLK	9.0	4.0	-	-	3466_14:75245382-75245382 C>T_NEEVPPPLPPEELQSEDPEEDARLK	0.0
14:75266025-75266025 C>T	1.0	2591	MELANOMA	-	-	-	-	YLPM1	ENST00000238571,p.P1147L|NM_019589,p.P1342L|ENST00000549293,p.P895L|ENST00000325680,p.P1342L|uc001xqj.4,p.P1342L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001xqj.4	nonsynonymous SNV	exon5	c.C4025T	p.P1342L	SLPPLPPLPPLPPLDRYRDDRWREE	SLPPLPPLPPLPLLDRYRDDRWREE	7.0	4.0	-	-	2591_14:75266025-75266025 C>T_SLPPLPPLPPLPLLDRYRDDRWREE	0.0
4:121774625-121774625 C>G	0.0	4238	COLORECTAL	-	-	-	-	PRDM5	NM_001300823,p.R83P|ENST00000264808,p.R83P|ENST00000515109,p.R83P|uc003ido.3,p.R83P|NM_018699,p.R83P|uc010inf.3,p.R83P|NM_001300824,p.R83P|ENST00000394435,p.R83P|uc003idp.1,p.R83P|uc010ine.3,p.R83P|uc003idn.3,p.R83P|ENST00000428209,p.R83P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010inf.3	nonsynonymous SNV	exon3	c.G248C	p.R83P	LDATNPRHSNWLRFVHEAPSQEQKN	LDATNPRHSNWLPFVHEAPSQEQKN	5.0	10.0	-	-	4238_4:121774625-121774625 C>G_LDATNPRHSNWLPFVHEAPSQEQKN	0.0
X:85211198-85211198 G>A	1.0	3919	MELANOMA	-	-	-	-	CHM	NM_000390,p.P376S|uc004eet.3,p.P376S|ENST00000357749,p.P376S|ENST00000537751,p.P228S|uc011mqz.2,p.P228S	protein_coding, processed_transcript	uc011mqz.2	nonsynonymous SNV	exon5	c.C682T	p.P228S	CLGRYGNTPFLFPLYGQGELPQCFC	CLGRYGNTPFLFSLYGQGELPQCFC	8.0	9.0	-	-	3919_X:85211198-85211198 G>A_CLGRYGNTPFLFSLYGQGELPQCFC	0.0
7:133861794-133861794 G>T	0.0	4237	NSCLC	-	-	-	-	LRGUK	uc003vrm.1,p.K362N|NM_144648,p.K362N|ENST00000285928,p.K362N	protein_coding, processed_transcript	uc003vrm.1	nonsynonymous SNV	exon9	c.G1086T	p.K362N	IFMLLRLTELDQKKIKVEEKVSAVN	IFMLLRLTELDQNKIKVEEKVSAVN	3.0	7.0	-	-	4237_7:133861794-133861794 G>T_IFMLLRLTELDQNKIKVEEKVSAVN	0.0
2:186656841-186656841 G>A	0.0	4129	NSCLC	-	-	-	-	FSIP2	ENST00000424728,p.V1660M|ENST00000343098,p.V1749M|uc002upl.3,p.V1749M|NM_173651,p.V1749M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002upl.3	nonsynonymous SNV	exon16	c.G5245A	p.V1749M	SAILKVIQTELNVTSSDLKTSVENP	SAILKVIQTELNMTSSDLKTSVENP	3.0	7.0	-	-	4129_2:186656841-186656841 G>A_SAILKVIQTELNMTSSDLKTSVENP	0.0
19:57175423-57175423 G>A	0.0	3903	MELANOMA	-	-	-	-	ZNF835	NM_001005850,p.L382F|uc031rne.1,p.L382F|uc010ygn.2,p.L382F|ENST00000537055,p.L382F	protein_coding	uc031rne.1	nonsynonymous SNV	exon1	c.C1144T	p.L382F	RFSNRSHLLQHRLVHTGERPYRCLQ	RFSNRSHLLQHRFVHTGERPYRCLQ	2.0	9.0	-	-	3903_19:57175423-57175423 G>A_RFSNRSHLLQHRFVHTGERPYRCLQ	0.0
8:124824829-124824829 C>T	1.0	4244	COLORECTAL	-	-	-	-	FAM91A1	NM_144963,p.A801V|uc003yqv.3,p.A801V	retained_intron, protein_coding, nonsense_mediated_decay	uc003yqv.3	nonsynonymous SNV	exon24	c.C2402T	p.A801V	PSFSSLLSQSSYADMGVPLPAKNLI	PSFSSLLSQSSYVDMGVPLPAKNLI	8.0	7.0	-	-	4244_8:124824829-124824829 C>T_PSFSSLLSQSSYVDMGVPLPAKNLI	0.0
19:58718141-58718141 C>T	1.0	3879	MELANOMA	-	-	-	-	ZNF274	ENST00000345813,p.P72L|ENST00000326804,p.P104L|uc002qrq.1,p.P104L|uc002qrr.1,p.P72L|ENST00000594839,p.P104L	retained_intron, protein_coding, processed_transcript	uc002qrr.1	nonsynonymous SNV	exon4	c.C215T	p.P72L	LDPKLDPLPAESPLMNIEVVEVLTL	LDPKLDPLPAESLLMNIEVVEVLTL	6.0	5.0	-	-	3879_19:58718141-58718141 C>T_LDPKLDPLPAESLLMNIEVVEVLTL	0.0
15:99768907-99768907 G>A	1.0	3466	MELANOMA	-	-	-	-	TTC23	ENST00000394135,p.S4L|ENST00000459771,p.S4L|uc002buw.3,p.S4L|ENST00000394136,p.S4L|ENST00000558613,p.S4L|ENST00000394129,p.S4L|uc002buz.2,p.S4L|ENST00000560772,p.S4L|uc010bor.3,p.S4L|uc002buu.3,p.S4L|uc002but.3,p.S4L|NM_001288616,p.S4L|ENST00000558663,p.S4L|ENST00000394132,p.S4L|uc002bux.3,p.S4L|ENST00000561365,p.S4L|uc002bur.3,p.S4L|NM_001288615,p.S4L|uc002buy.3,p.S4L|ENST00000262074,p.S4L|uc002buv.3,p.S4L|ENST00000558078,p.S4L|ENST00000394130,p.S4L|ENST00000560279,p.S4L|ENST00000560860,p.S4L|uc002bus.3,p.S4L|ENST00000560235,p.S4L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bor.3	nonsynonymous SNV	exon3	c.C11T	p.S4L	MQESQETHISNHLDEV	MQELQETHISNHLDEV	6.0	6.0	-	-	3466_15:99768907-99768907 G>A_MQELQETHISNHLDEV	0.0
18:43217116-43217116 A>G	0.0	4160	COLORECTAL	-	-	-	-	SLC14A2	uc002lbb.3,p.N271S|NM_001242692,p.N271S|NM_007163,p.N271S|uc002lbe.3,p.N271S|ENST00000586448,p.N271S|uc010dnj.3,p.N271S|ENST00000255226,p.N271S	protein_coding, nonsense_mediated_decay	uc010dnj.3	nonsynonymous SNV	exon7	c.A812G	p.N271S	PTTLVEPVSSVPNITWTEMEMPLLL	PTTLVEPVSSVPSITWTEMEMPLLL	1.0	6.0	-	-	4160_18:43217116-43217116 A>G_PTTLVEPVSSVPSITWTEMEMPLLL	0.0
4:57215797-57215797 G>C	1.0	4301	MELANOMA	-	-	-	-	AASDH	ENST00000451613,p.P707R|uc010ihb.3,p.P222R|uc011cab.2,p.P222R|NM_181806,p.P707R|ENST00000205214,p.P707R|uc003hbo.3,p.P607R|NM_001286668,p.P607R|NM_001286672,p.P707R|uc010ihc.3,p.P707R|uc003hbp.3,p.P707R|NM_001286671,p.P707R|uc003hbn.3,p.P707R|ENST00000502617,p.P707R|ENST00000434343,p.P222R|ENST00000513376,p.P607R|NM_001286670,p.P222R|NM_001286669,p.P554R|ENST00000602986,p.P554R|uc011caa.2,p.P554R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cab.2	nonsynonymous SNV	exon8	c.C665G	p.P222R	FLTKLGHCSSACPSDSVSQTNIQNL	FLTKLGHCSSACRSDSVSQTNIQNL	8.0	1.0	-	-	4301_4:57215797-57215797 G>C_FLTKLGHCSSACRSDSVSQTNIQNL	0.0
17:58571953-58571953 C>G	1.0	3879	MELANOMA	-	-	-	-	APPBP2	uc002iys.1,p.A85P|ENST00000585368,p.A85P|ENST00000083182,p.A85P|NM_006380,p.A85P	protein_coding, processed_transcript, nonsense_mediated_decay	uc002iys.1	nonsynonymous SNV	exon3	c.G253C	p.A85P	LDKRHLLHHCFQALMDHGVKVASVL	LDKRHLLHHCFQPLMDHGVKVASVL	8.0	7.0	-	-	3879_17:58571953-58571953 C>G_LDKRHLLHHCFQPLMDHGVKVASVL	0.0
12:124827580-124827580 G>A	1.0	3678	MELANOMA	-	-	-	1	NCOR2	ENST00000397355,p.S1627F|uc021rgc.1,p.S1626F|uc010tbc.2,p.S1626F|NM_001077261,p.S1626F|ENST00000429285,p.S1626F|ENST00000356219,p.S1643F|ENST00000405201,p.S1636F|NM_001206654,p.S1626F|uc010tba.2,p.S1644F|uc010tbb.2,p.S1636F|ENST00000404621,p.S1626F|NM_006312,p.S1636F|ENST00000404121,p.S1197F	retained_intron, protein_coding	uc021rgc.1	nonsynonymous SNV	exon34	c.C4877T	p.S1626F	YRSHIPLAFDPTSIPRGIPLDAAAA	YRSHIPLAFDPTFIPRGIPLDAAAA	10.0	2.0	-	-	3678_12:124827580-124827580 G>A_YRSHIPLAFDPTFIPRGIPLDAAAA	0.0
20:16360132-16360132 A>C	1.0	4246	COLORECTAL	-	-	-	-	KIF16B	uc010gci.2,p.L839V|NM_001199866,p.L839V|ENST00000355755,p.L839V|ENST00000408042,p.L839V|uc002wpg.2,p.L839V|uc002wpf.1,p.L221V|ENST00000354981,p.L839V|uc010gcj.2,p.L850V|uc002wpe.1,p.L221V|uc010gch.2,p.L839V|NM_024704,p.L839V|NM_001199865,p.L839V|ENST00000378003,p.L65V	protein_coding	uc010gcj.2	nonsynonymous SNV	exon20	c.T2548G	p.L850V	EFKRRQLVKLVNLEKDLVQQKDILK	EFKRRQLVKLVNVEKDLVQQKDILK	10.0	5.0	-	-	4246_20:16360132-16360132 A>C_EFKRRQLVKLVNVEKDLVQQKDILK	0.0
1:22188571-22188571 A>T	1.0	4287	COLORECTAL	-	-	-	-	HSPG2	ENST00000374695,p.L1593H|uc009vqd.3,p.L1594H|NM_001291860,p.L1594H|NM_005529,p.L1593H|uc001bfj.3,p.L1593H	protein_coding, processed_transcript, nonsense_mediated_decay	uc009vqd.3	nonsynonymous SNV	exon38	c.T4781A	p.L1594H	QCQHNAAGEFCELCAPGYYGDATAG	QCQHNAAGEFCEHCAPGYYGDATAG	8.0	7.0	-	-	4287_1:22188571-22188571 A>T_QCQHNAAGEFCEHCAPGYYGDATAG	0.0
3:37343751-37343751 C>T	1.0	3713	MELANOMA	-	-	-	-	GOLGA4	uc003cgv.3,p.R388C|ENST00000361924,p.R388C|ENST00000356847,p.R410C|uc003cgw.3,p.R410C|ENST00000437131,p.R259C|uc003cgx.3,p.R269C|NM_002078,p.R388C|NM_001172713,p.R410C|ENST00000450863,p.R393C	retained_intron, protein_coding, processed_transcript	uc003cgx.3	nonsynonymous SNV	exon8	c.C805T	p.R269C	TLEMKEEEIAQLRSRIKQMTTQGEE	TLEMKEEEIAQLCSRIKQMTTQGEE	9.0	4.0	-	-	3713_3:37343751-37343751 C>T_TLEMKEEEIAQLCSRIKQMTTQGEE	0.0
3:14209829-14209829 C>T	0.0	3775	CERVICAL	-	-	-	1	XPC	NM_004628,p.R155Q|ENST00000285021,p.R155Q|uc011ave.2,p.R155Q|ENST00000511155,p.R149Q	retained_intron, protein_coding, nonsense_mediated_decay	uc011ave.2	nonsynonymous SNV	exon4	c.G464A	p.R155Q	VLGDVRESTAFSRSLLPVKPVEIEI	VLGDVRESTAFSQSLLPVKPVEIEI	8.0	3.0	-	-	3775_3:14209829-14209829 C>T_VLGDVRESTAFSQSLLPVKPVEIEI	0.0
17:27208849-27208849 C>G	1.0	3775	CERVICAL	-	-	-	-	FLOT2	ENST00000585169,p.Q299H|ENST00000394908,p.Q299H|uc002hdc.3,p.Q299H|ENST00000394906,p.Q354H|NM_004475,p.Q299H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hdc.3	nonsynonymous SNV	exon8	c.G897C	p.Q299H	RRPAEAEAHRIQQIAEGEKVKQVLL	RRPAEAEAHRIQHIAEGEKVKQVLL	10.0	8.0	-	-	3775_17:27208849-27208849 C>G_RRPAEAEAHRIQHIAEGEKVKQVLL	0.0
16:56871607-56871607 C>A	0.0	4081	COLORECTAL	-	-	-	-	NUP93	NM_001242796,p.L540M|NM_014669,p.L663M|uc010vhi.2,p.L540M|uc002eka.3,p.L663M|ENST00000542526,p.L540M|ENST00000563405,p.L61M|uc002ekb.3,p.L540M|ENST00000564887,p.L540M|NM_001242795,p.L540M|ENST00000569842,p.L663M|ENST00000308159,p.L663M	retained_intron, protein_coding, processed_transcript, TEC	uc010vhi.2	nonsynonymous SNV	exon16	c.C1618A	p.L540M	PQISAPQSNKERLKNMALSIAERYR	PQISAPQSNKERMKNMALSIAERYR	6.0	6.0	-	-	4081_16:56871607-56871607 C>A_PQISAPQSNKERMKNMALSIAERYR	0.0
5:149262993-149262993 T>A	1.0	4317	COLORECTAL	-	-	-	-	PDE6A	uc003lrg.4,p.M712L|ENST00000255266,p.M712L|uc021yfs.1,p.M631L|NM_000440,p.M712L	retained_intron, protein_coding	uc021yfs.1	nonsynonymous SNV	exon15	c.A1891T	p.M631L	YMMLEQTRKEIVMAMMMTACDLSAI	YMMLEQTRKEIVLAMMMTACDLSAI	3.0	10.0	-	-	4317_5:149262993-149262993 T>A_YMMLEQTRKEIVLAMMMTACDLSAI	0.0
2:51255027-51255027 A>T	0.0	4196	COLORECTAL	-	-	-	-	NRXN1	uc021vhh.1,p.F129I|ENST00000406859,p.F129I|ENST00000406316,p.F129I|uc021vhk.1,p.F129I|NM_004801,p.F129I|ENST00000404971,p.F129I|ENST00000401669,p.F129I|uc021vhj.1,p.F129I|ENST00000405581,p.F129I|ENST00000405472,p.F129I|uc021vhg.1,p.F129I|ENST00000402717,p.F129I|NM_001135659,p.F129I|uc021vhi.1,p.F129I	retained_intron, protein_coding, processed_transcript	uc021vhk.1	nonsynonymous SNV	exon2	c.T385A	p.F129I	VRIRRQFRNTTLFIDQVEAKWVEVK	VRIRRQFRNTTLIIDQVEAKWVEVK	5.0	9.0	-	-	4196_2:51255027-51255027 A>T_VRIRRQFRNTTLIIDQVEAKWVEVK	0.0
12:52774154-52774154 C>T	0.0	4110	BILE DUCT	-	-	-	-	KRT84	ENST00000257951,p.E473K|NM_033045,p.E473K|uc001sah.1,p.E473K	protein_coding	uc001sah.1	nonsynonymous SNV	exon7	c.G1417A	p.E473K	EIATYRRLLEGEESRLCEGVGPVNI	EIATYRRLLEGEKSRLCEGVGPVNI	3.0	6.0	-	-	4110_12:52774154-52774154 C>T_EIATYRRLLEGEKSRLCEGVGPVNI	0.0
22:21349261-21349261 C>T	1.0	4213	COLORECTAL	-	-	-	1	LZTR1	uc011ahy.2,p.R611W|ENST00000389355,p.R611W|ENST00000215739,p.R630W|uc002zto.3,p.R630W|ENST00000452988,p.R23W|uc002ztn.3,p.R589W|NM_006767,p.R630W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ahy.2	nonsynonymous SNV	exon15	c.C1831T	p.R611W	ERLSSPLIVEIVRRKQQPPPRTPLD	ERLSSPLIVEIVWRKQQPPPRTPLD	9.0	5.0	-	-	4213_22:21349261-21349261 C>T_ERLSSPLIVEIVWRKQQPPPRTPLD	0.0
13:41706446-41706446 C>G	0.0	4240	BREAST	-	-	-	-	KBTBD6	uc001uxu.1,p.E68Q|ENST00000379485,p.E68Q|NM_152903,p.E68Q	protein_coding	uc001uxu.1	nonsynonymous SNV	exon1	c.G202C	p.E68Q	FYDARLLCDVTIEVVTPGSGPGTGR	FYDARLLCDVTIQVVTPGSGPGTGR	6.0	10.0	-	-	4240_13:41706446-41706446 C>G_FYDARLLCDVTIQVVTPGSGPGTGR	0.0
16:67778313-67778313 G>A	1.0	3466	MELANOMA	-	-	-	-	RANBP10	uc010vjx.1,p.S149L|uc010vjv.2,p.S32L|ENST00000602677,p.S149L|uc002eud.3,p.S149L|NM_020850,p.S149L|ENST00000411657,p.S32L|ENST00000425512,p.S17L|ENST00000317506,p.S149L|uc010vjy.1,p.S17L	protein_coding	uc010vjy.1	nonsynonymous SNV	exon3	c.C50T	p.S17L	KHSYGYHGDDGHSFCSSGTGQPYGP	KHSYGYHGDDGHLFCSSGTGQPYGP	5.0	2.0	-	-	3466_16:67778313-67778313 G>A_KHSYGYHGDDGHLFCSSGTGQPYGP	0.0
17:29631452-29631452 T>C	0.0	4317	COLORECTAL	-	-	-	-	EVI2B	ENST00000544462,p.I407M|ENST00000577894,p.I392M|ENST00000330927,p.I392M|uc021tuk.1,p.I392M|uc002hgk.2,p.I392M|NM_006495,p.I392M|uc010csq.2,p.I407M	protein_coding	uc021tuk.1	nonsynonymous SNV	exon1	c.A1176G	p.I392M	LNQDCGDHKSEIIQSFPPLDSLNLP	LNQDCGDHKSEIMQSFPPLDSLNLP	5.0	2.0	-	-	4317_17:29631452-29631452 T>C_LNQDCGDHKSEIMQSFPPLDSLNLP	0.0
5:140711128-140711128 C>T	1.0	3903	MELANOMA	-	-	ID=COSM139619,COSM139618;OCCURENCE=5(skin)	-	PCDHGA1	NM_031993,p.R293C|ENST00000378105,p.R293C|uc011dan.2,p.R293C|ENST00000517417,p.R293C|uc003lji.2,p.R293C|NM_018912,p.R293C	protein_coding	uc011dan.2	nonsynonymous SNV	exon1	c.C877T	p.R293C	FHNVDHRVAQIFRLDSYTGEISNKE	FHNVDHRVAQIFCLDSYTGEISNKE	5.0	6.0	-	-	3903_5:140711128-140711128 C>T_FHNVDHRVAQIFCLDSYTGEISNKE	0.0
11:46391078-46391078 C>T	1.0	3713	MELANOMA	-	-	-	-	DGKZ	uc010rgr.2,p.S164L|ENST00000421244,p.S160L|ENST00000456247,p.S159L|uc001ncn.1,p.S348L|uc001nch.2,p.S176L|NM_001105540,p.S348L|ENST00000343674,p.S176L|uc001ncl.2,p.S160L|ENST00000527911,p.S160L|ENST00000454345,p.S348L|ENST00000395574,p.S126L|ENST00000532868,p.S164L|NM_001199266,p.S160L|uc001ncm.2,p.S159L|NM_201533,p.S164L|uc009yky.1,p.S160L|NM_003646,p.S160L|NM_001199267,p.S159L|NM_201532,p.S176L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rgr.2	nonsynonymous SNV	exon5	c.C491T	p.S164L	KINFRCKPSFRESGSRNVREPTFVR	KINFRCKPSFRELGSRNVREPTFVR	8.0	7.0	-	-	3713_11:46391078-46391078 C>T_KINFRCKPSFRELGSRNVREPTFVR	0.0
9:139794982-139794982 C>A	1.0	4252	COLORECTAL	-	-	-	-	TRAF2	ENST00000359662,p.P126T|uc010nbv.1,p.P126T	protein_coding, processed_transcript	uc010nbv.1	nonsynonymous SNV	exon4	c.C376A	p.P126T	WKGTLKEYEVKMPACGMVTEAPAVG	WKGTLKEYEVKMTACGMVTEAPAVG	9.0	7.0	-	-	4252_9:139794982-139794982 C>A_WKGTLKEYEVKMTACGMVTEAPAVG	0.0
11:62639124-62639124 A>C	1.0	4136	BREAST	-	-	-	-	SLC3A2	ENST00000377891,p.K63T|uc001nwc.3,p.K63T|NM_001012662,p.K63T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001nwc.3	nonsynonymous SNV	exon2	c.A188C	p.K63T	LLASSDPPALASKNAEVTVETGFHH	LLASSDPPALASTNAEVTVETGFHH	10.0	7.0	-	-	4136_11:62639124-62639124 A>C_LLASSDPPALASTNAEVTVETGFHH	0.0
15:32685308-32685308 G>A	1.0	4326	BREAST	-	-	-	-	GOLGA8K	ENST00000512626,p.P551L|NM_001282493,p.P551L	protein_coding	NM_001282493	nonsynonymous SNV	exon18	c.C1652T	p.P551L	NGHRKFLAAAHNPADEPGPGAPAPQ	NGHRKFLAAAHNLADEPGPGAPAPQ	6.0	6.0	-	-	4326_15:32685308-32685308 G>A_NGHRKFLAAAHNLADEPGPGAPAPQ	0.0
22:50192330-50192330 T>G	1.0	4320	COLORECTAL	-	-	-	-	BRD1	uc003biv.3,p.K554T|ENST00000542442,p.K247T|ENST00000342989,p.K149T|NM_014577,p.K554T|uc011arg.2,p.K608T|ENST00000457780,p.K554T|ENST00000404760,p.K554T|ENST00000216267,p.K554T|ENST00000438393,p.K186T|uc011arf.2,p.K149T|uc003biu.4,p.K554T|ENST00000404034,p.K554T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011arg.2	nonsynonymous SNV	exon5	c.A1823C	p.K608T	LRKREKLKREQVKVEQVAMELRLTP	LRKREKLKREQVTVEQVAMELRLTP	7.0	2.0	-	-	4320_22:50192330-50192330 T>G_LRKREKLKREQVTVEQVAMELRLTP	0.0
8:91075378-91075378 T>A	0.0	4077	BILE DUCT	-	-	-	-	CALB1	ENST00000265431,p.I184F|ENST00000518457,p.I127F|uc011lge.1,p.I127F|NM_004929,p.I184F|uc003yel.1,p.I184F	retained_intron, protein_coding	uc011lge.1	nonsynonymous SNV	exon8	c.A379T	p.I127F	PVQENFLLKFQGIKMCGKEFNKAFE	PVQENFLLKFQGFKMCGKEFNKAFE	1.0	10.0	-	-	4077_8:91075378-91075378 T>A_PVQENFLLKFQGFKMCGKEFNKAFE	0.0
3:189681871-189681871 T>A	1.0	3713	MELANOMA	-	-	-	-	LEPREL1	uc003fsg.3,p.K456I|NM_001134418,p.K456I|NM_018192,p.K637I|uc011bsk.2,p.K637I|ENST00000427335,p.K456I|ENST00000319332,p.K637I	retained_intron, protein_coding	uc011bsk.2	nonsynonymous SNV	exon14	c.A1910T	p.K637I	MDAKTVTASIKPKCGRMISFSSGGE	MDAKTVTASIKPICGRMISFSSGGE	2.0	3.0	-	-	3713_3:189681871-189681871 T>A_MDAKTVTASIKPICGRMISFSSGGE	0.0
3:111564691-111564691 C>T	1.0	3713	MELANOMA	-	-	-	-	PLCXD2	uc003dxz.3,p.P297L|NM_153268,p.P297L|ENST00000393934,p.P297L	retained_intron, protein_coding, processed_transcript	uc003dxz.3	nonsynonymous SNV	exon4	c.C890T	p.P297L	TLVHRLALIPVYPLRFSRRS	TLVHRLALIPVYLLRFSRRS	1.0	2.0	-	-	3713_3:111564691-111564691 C>T_TLVHRLALIPVYLLRFSRRS	0.0
12:4705427-4705427 T>G	0.0	3713	MELANOMA	-	-	-	-	DYRK4	uc009zeh.1,p.L247R|ENST00000010132,p.L132R|uc001qmy.2,p.L132R|ENST00000542744,p.L247R|ENST00000543431,p.L132R|ENST00000540757,p.L132R|NM_003845,p.L132R|uc001qmx.3,p.L132R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zeh.1	nonsynonymous SNV	exon7	c.T740G	p.L247R	KCLDHKNNELVALKIIRNKKRFHQQ	KCLDHKNNELVARKIIRNKKRFHQQ	5.0	9.0	-	-	3713_12:4705427-4705427 T>G_KCLDHKNNELVARKIIRNKKRFHQQ	0.0
12:4700436-4700436 G>C	0.0	3466	MELANOMA	-	-	-	-	DYRK4	ENST00000010132,p.K30N|ENST00000543431,p.K30N|uc001qmx.3,p.K30N|ENST00000542744,p.K145N|uc001qmy.2,p.K30N|NM_003845,p.K30N|uc009zeh.1,p.K145N|ENST00000540757,p.K30N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zeh.1	nonsynonymous SNV	exon5	c.G435C	p.K145N	KTQDPKAEEKSPKKQKVTLTAAEAL	KTQDPKAEEKSPNKQKVTLTAAEAL	6.0	3.0	-	-	3466_12:4700436-4700436 G>C_KTQDPKAEEKSPNKQKVTLTAAEAL	0.0
4:126372414-126372414 G>C	0.0	4245	COLORECTAL	-	-	-	1	FAT4	NM_024582,p.E3415Q|ENST00000335110,p.E1713Q|NM_001291285,p.E3417Q|uc003ifj.4,p.E3415Q|uc003ifi.1,p.E893Q|uc011cgp.2,p.E1713Q|ENST00000394329,p.E3415Q|NM_001291303,p.E3417Q	retained_intron, protein_coding	uc011cgp.2	nonsynonymous SNV	exon9	c.G5137C	p.E1713Q	IFTLNIYSVQISEGVPIGTHVTFVS	IFTLNIYSVQISQGVPIGTHVTFVS	4.0	3.0	-	-	4245_4:126372414-126372414 G>C_IFTLNIYSVQISQGVPIGTHVTFVS	0.0
12:118198975-118198975 G>A	0.0	4196	COLORECTAL	-	-	-	-	KSR2	NM_173598,p.T247M|ENST00000425217,p.T247M|uc001two.2,p.T247M|ENST00000339824,p.T276M	retained_intron, protein_coding, processed_transcript	uc001two.2	nonsynonymous SNV	exon4	c.C740T	p.T247M	TPNIVTTVTPPGTPPMRKKNKLKPP	TPNIVTTVTPPGMPPMRKKNKLKPP	5.0	7.0	-	-	4196_12:118198975-118198975 G>A_TPNIVTTVTPPGMPPMRKKNKLKPP	0.0
19:33703262-33703262 A>T	0.0	4298	COLORECTAL	-	-	-	-	SLC7A10	ENST00000590036,p.S242T|uc002num.2,p.S242T|uc010xrq.2,p.S215T|ENST00000253188,p.S242T|NM_019849,p.S242T	protein_coding, nonsense_mediated_decay	uc010xrq.2	nonsynonymous SNV	exon4	c.T643A	p.S215T	SVGHLALAFLQGSFAFSGWNFLNYV	SVGHLALAFLQGTFAFSGWNFLNYV	2.0	6.0	-	-	4298_19:33703262-33703262 A>T_SVGHLALAFLQGTFAFSGWNFLNYV	0.0
6:87726049-87726049 G>A	0.0	4259	COLORECTAL	-	-	-	-	HTR1E	ENST00000305344,p.G333S|uc021zcg.1,p.G333S|uc003pli.3,p.G333S|ENST00000369584,p.G333S|NM_000865,p.G333S	protein_coding	uc021zcg.1	nonsynonymous SNV	exon1	c.G997A	p.G333S	VSSEVADFLTWLGYVNSLINPLLYT	VSSEVADFLTWLSYVNSLINPLLYT	1.0	8.0	-	-	4259_6:87726049-87726049 G>A_VSSEVADFLTWLSYVNSLINPLLYT	0.0
10:61005340-61005340 G>T	0.0	4326	BREAST	-	-	-	-	PHYHIPL	uc001jkl.4,p.V328F|uc001jkm.4,p.V348F|ENST00000373880,p.V374F|uc001jkk.4,p.V374F|NM_032439,p.V374F|ENST00000373878,p.V348F|NM_001143774,p.V348F	protein_coding, processed_transcript, nonsense_mediated_decay	uc001jkm.4	nonsynonymous SNV	exon5	c.G1042T	p.V348F	KKDPSCKTCNISVGR	KKDPSCKTCNISFGR	3.0	2.0	-	-	4326_10:61005340-61005340 G>T_KKDPSCKTCNISFGR	0.0
1:223408366-223408366 G>C	0.0	4126	NSCLC	-	-	-	-	SUSD4	uc001hnz.2,p.C267W|ENST00000344029,p.C267W|NM_001037175,p.C267W	protein_coding, processed_transcript	uc001hnz.2	nonsynonymous SNV	exon6	c.C801G	p.C267W	PHIRLAAAVLYFCPVLKSSPTPAPT	PHIRLAAAVLYFWPVLKSSPTPAPT	3.0	1.0	-	-	4126_1:223408366-223408366 G>C_PHIRLAAAVLYFWPVLKSSPTPAPT	0.0
15:25222154-25222154 G>A	0.0	4155	MELANOMA	-	-	-	-	SNRPN	ENST00000579070,p.G133E|uc021sga.1,p.G133E|uc001yws.1,p.G133E|ENST00000400100,p.G133E|ENST00000577565,p.G133E|NM_022805,p.G133E|ENST00000400098,p.G133E|uc001ywq.1,p.G133E|ENST00000346403,p.G133E|uc001ywt.1,p.G133E|NM_003097,p.G133E|uc001ywr.1,p.G133E|uc021sgb.1,p.G136E|NM_022807,p.G133E|ENST00000444203,p.G137E|uc001ywp.1,p.G133E|NM_022806,p.G133E|NM_022808,p.G133E|ENST00000390687,p.G133E|ENST00000554227,p.G137E|ENST00000400097,p.G133E	protein_coding, processed_transcript	uc021sgb.1	nonsynonymous SNV	exon5	c.G407A	p.G136E	PQAPAGLAGPVRGVGGPSQQVMTPQ	PQAPAGLAGPVREVGGPSQQVMTPQ	9.0	7.0	-	-	4155_15:25222154-25222154 G>A_PQAPAGLAGPVREVGGPSQQVMTPQ	0.0
2:174227970-174227970 G>C	1.0	4284	COLORECTAL	-	-	-	-	CDCA7	NM_145810,p.R55P|ENST00000347703,p.R55P|ENST00000392567,p.R55P|uc002uid.1,p.R55P	retained_intron, protein_coding, nonsense_mediated_decay	uc002uid.1	nonsynonymous SNV	exon3	c.G164C	p.R55P	SDNFANTRLQSVREGCRTRSQCRHS	SDNFANTRLQSVPEGCRTRSQCRHS	10.0	7.0	-	-	4284_2:174227970-174227970 G>C_SDNFANTRLQSVPEGCRTRSQCRHS	0.0
3:30691841-30691841 G>A	1.0	4284	COLORECTAL	-	-	-	1	TGFBR2	NM_001024847,p.D140N|uc003cen.3,p.D140N|ENST00000295754,p.D115N|uc003ceo.3,p.D115N|ENST00000359013,p.D140N|NM_003242,p.D115N	protein_coding	uc003ceo.3	nonsynonymous SNV	exon3	c.G343A	p.D115N	DPKLPYHDFILEDAASPKCIMKEKK	DPKLPYHDFILENAASPKCIMKEKK	9.0	1.0	-	-	4284_3:30691841-30691841 G>A_DPKLPYHDFILENAASPKCIMKEKK	0.0
8:146067588-146067588 G>A	1.0	4237	NSCLC	-	-	-	-	ZNF7	uc011lln.2,p.E270K|uc010mge.3,p.E377K|ENST00000544249,p.E270K|ENST00000446747,p.E377K|NM_001282797,p.E270K|uc003zek.4,p.E270K|NM_001282795,p.E377K|uc003zeg.4,p.E366K|NM_003416,p.E366K|ENST00000528372,p.E366K|ENST00000325241,p.E366K	retained_intron, protein_coding, processed_transcript	uc011lln.2	nonsynonymous SNV	exon4	c.G808A	p.E270K	RTHTGERPYPCKECGKAFSQSSTLA	RTHTGERPYPCKKCGKAFSQSSTLA	8.0	9.0	-	-	4237_8:146067588-146067588 G>A_RTHTGERPYPCKKCGKAFSQSSTLA	0.0
4:69796933-69796933 ->T	0.0	4158	COLORECTAL	-	-	ID=COSM1430668;OCCURENCE=1(large_intestine)	-	UGT2A3	ENST00000420231,p.P53fs|uc003hef.2,p.P342fs|NM_024743,p.P342fs|ENST00000251566,p.P342fs	protein_coding, nonsense_mediated_decay	uc003hef.2	frameshift insertion	exon4	c.1023dupA	p.P342fs	PQKVLWRYKGKKPSTLGANTRLYDW	PQKVLWRYKGKKTIHIRSQYSAV	4.0	9.0	-	-	4158_4:69796933-69796933 ->T_PQKVLWRYKGKKTIHIRSQYSAV	0.0
2:225670195-225670195 G>A	1.0	4000	MELANOMA	-	-	-	-	DOCK10	NM_014689,p.S1289F|uc010fwz.1,p.S1289F|ENST00000409592,p.S1283F|ENST00000258390,p.S1289F|NM_001290263,p.S1283F|uc002vob.2,p.S1283F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010fwz.1	nonsynonymous SNV	exon35	c.C3866T	p.S1289F	AISTVNHADSRASLASLDSNPSTNE	AISTVNHADSRAFLASLDSNPSTNE	10.0	7.0	-	-	4000_2:225670195-225670195 G>A_AISTVNHADSRAFLASLDSNPSTNE	0.0
7:154862986-154862986 C>T	0.0	4329	COLORECTAL	-	-	-	-	HTR5A	ENST00000287907,p.T126M|uc003wlu.2,p.T126M|NM_024012,p.T126M	protein_coding, processed_transcript	uc003wlu.2	nonsynonymous SNV	exon1	c.C377T	p.T126M	CQLWIACDVLCCTASIWNVTAIALD	CQLWIACDVLCCMASIWNVTAIALD	1.0	6.0	-	-	4329_7:154862986-154862986 C>T_CQLWIACDVLCCMASIWNVTAIALD	0.0
5:36677147-36677147 G>T	0.0	4245	COLORECTAL	-	-	-	-	SLC1A3	NM_001289939,p.V195F|ENST00000265113,p.V241F|uc003jkj.4,p.V241F|uc011cox.2,p.V134F|ENST00000381918,p.V241F|NM_004172,p.V241F|uc010iuy.3,p.V241F|NM_001166695,p.V241F	retained_intron, protein_coding, processed_transcript	uc011cox.2	nonsynonymous SNV	exon5	c.G400T	p.V134F	EELVPVPGSVNGVNALGLVVFSMCF	EELVPVPGSVNGFNALGLVVFSMCF	6.0	3.0	-	-	4245_5:36677147-36677147 G>T_EELVPVPGSVNGFNALGLVVFSMCF	0.0
5:140750281-140750281 A>T	0.0	3795	MELANOMA	-	-	-	-	PCDHGB3	NM_018924,p.E107V|ENST00000576222,p.E107V|uc003ljw.2,p.E107V|NM_032097,p.E107V|uc011dat.2,p.E107V	protein_coding	uc011dat.2	nonsynonymous SNV	exon1	c.A320T	p.E107V	ICGKKSTCVLEFEMVAEKPLNFFHV	ICGKKSTCVLEFVMVAEKPLNFFHV	3.0	10.0	-	-	3795_5:140750281-140750281 A>T_ICGKKSTCVLEFVMVAEKPLNFFHV	0.0
21:45539291-45539291 G>A	1.0	4129	NSCLC	-	-	-	-	PWP2	NM_005049,p.E359K|ENST00000291576,p.E359K|uc002zeb.3,p.E359K	retained_intron, protein_coding, processed_transcript	uc002zeb.3	nonsynonymous SNV	exon10	c.G1075A	p.E359K	FGCSGLGQLLVWEWQSESYVLKQQG	FGCSGLGQLLVWKWQSESYVLKQQG	8.0	7.0	-	-	4129_21:45539291-45539291 G>A_FGCSGLGQLLVWKWQSESYVLKQQG	0.0
5:140740133-140740133 A>T	1.0	4129	NSCLC	-	-	-	-	PCDHGB2	uc011dar.2,p.E144V|ENST00000522605,p.E144V|NM_032096,p.E144V|uc003ljs.2,p.E144V|NM_018923,p.E144V	protein_coding	uc011dar.2	nonsynonymous SNV	exon1	c.A431T	p.E144V	LFKQTKINLKIGESTKPGTTFPLDP	LFKQTKINLKIGVSTKPGTTFPLDP	3.0	8.0	-	-	4129_5:140740133-140740133 A>T_LFKQTKINLKIGVSTKPGTTFPLDP	0.0
4:74280829-74280829 C>T	0.0	4301	MELANOMA	-	-	-	-	ALB	uc011cbe.2,p.T58I|NM_000477,p.T379I|ENST00000509063,p.T379I|ENST00000503124,p.T229I|ENST00000295897,p.T379I|uc003hgw.4,p.T187I|uc011cbf.2,p.T269I|uc003hgs.4,p.T379I|ENST00000401494,p.T264I|ENST00000415165,p.T187I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cbf.2	nonsynonymous SNV	exon8	c.C806T	p.T269I	VVLLLRLAKTYETTLEKCCAAADPH	VVLLLRLAKTYEITLEKCCAAADPH	3.0	2.0	-	-	4301_4:74280829-74280829 C>T_VVLLLRLAKTYEITLEKCCAAADPH	0.0
19:6468407-6468407 T>G	1.0	4317	COLORECTAL	-	-	-	-	DENND1C	uc010xje.2,p.E499D|uc002mfe.3,p.E543D|NM_001290331,p.E499D|uc002mfb.3,p.E93D|NM_024898,p.E543D|ENST00000381480,p.E543D|uc002mfc.3,p.E93D|ENST00000543576,p.E499D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xje.2	nonsynonymous SNV	exon20	c.A1497C	p.E499D	PLSPEDEGCPWAEEALDSSFLGSGE	PLSPEDEGCPWADEALDSSFLGSGE	5.0	1.0	-	-	4317_19:6468407-6468407 T>G_PLSPEDEGCPWADEALDSSFLGSGE	0.0
13:36827969-36827969 G>A	0.0	4316	COLORECTAL	0.0041	-	-	-	CCDC169,CCDC169-SOHLH2	ENST00000506800,p.R45C|NM_001144983,p.R45C|ENST00000511166,p.R47C|ENST00000554962,p.R47C|uc010abm.3,p.R147C|uc010tek.2,p.R45C|uc010tei.2,p.R47C|NM_001144986,p.R45C|uc010abo.3,p.R45C|ENST00000510088,p.R45C|NM_001144981,p.R147C|ENST00000491049,p.R45C|NM_001198910,p.R47C|NM_001144982,p.R45C|NM_001144985,p.R45C|uc010tem.2,p.R147C|NM_001198908,p.R147C|uc010tel.2,p.R47C|uc010abn.3,p.R45C|ENST00000503173,p.R147C|ENST00000379864,p.R45C|NM_001144984,p.R47C|ENST00000239860,p.R47C|uc010tej.2,p.R45C|ENST00000239859,p.R147C|ENST00000379862,p.R45C	protein_coding	uc010tem.2	nonsynonymous SNV	exon6	c.C439T	p.R147C	QESKAYQKINNERRTYLAEMSQGSG	QESKAYQKINNECRTYLAEMSQGSG	4.0	4.0	-	-	4316_13:36827969-36827969 G>A_QESKAYQKINNECRTYLAEMSQGSG	0.0
20:23614602-23614602 G>A	1.0	4287	COLORECTAL	-	-	-	-	CST3	NM_000099,p.P131L|uc002wtm.3,p.P131L|NM_001288614,p.P131L|ENST00000398411,p.P131L|uc002wtn.1,p.P131L|ENST00000398409,p.P131L|ENST00000376925,p.P131L	protein_coding	uc002wtn.1	nonsynonymous SNV	exon3	c.C392T	p.P131L	RKAFCSFQIYAVPWQGTMTLSKSTC	RKAFCSFQIYAVLWQGTMTLSKSTC	10.0	1.0	-	-	4287_20:23614602-23614602 G>A_RKAFCSFQIYAVLWQGTMTLSKSTC	0.0
19:9677481-9677481 A>G	1.0	4037	NSCLC	-	-	-	-	ZNF121	uc010xkp.1,p.L103P|ENST00000591447,p.L103P|uc010xkq.1,p.L103P|NM_001008727,p.L103P|ENST00000320451,p.L103P|ENST00000586602,p.L103P|uc010dwt.2,p.L103P	protein_coding, processed_transcript	uc010xkq.1	nonsynonymous SNV	exon5	c.T308C	p.L103P	SDCEEAFVDQSHLQANRITHNGETL	SDCEEAFVDQSHPQANRITHNGETL	8.0	10.0	-	-	4037_19:9677481-9677481 A>G_SDCEEAFVDQSHPQANRITHNGETL	0.0
17:80071449-80071449 C>T	1.0	3678	MELANOMA	-	-	-	-	CCDC57	uc002kdy.3,p.R226Q|ENST00000392346,p.R277Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kdy.3	nonsynonymous SNV	exon5	c.G677A	p.R226Q	ASLVRSTWAPGMRGGMNGGSSSVCK	ASLVRSTWAPGMQGGMNGGSSSVCK	8.0	3.0	-	-	3678_17:80071449-80071449 C>T_ASLVRSTWAPGMQGGMNGGSSSVCK	0.0
19:58189982-58189982 G>T	0.0	4284	COLORECTAL	-	-	-	-	ZSCAN4	ENST00000318203,p.E337D|NM_152677,p.E337D|uc002qpu.3,p.E337D	protein_coding	uc002qpu.3	nonsynonymous SNV	exon5	c.G1011T	p.E337D	CHLLAHQRRHRNERPFVCPECQKGF	CHLLAHQRRHRNDRPFVCPECQKGF	1.0	7.0	-	-	4284_19:58189982-58189982 G>T_CHLLAHQRRHRNDRPFVCPECQKGF	0.0
2:169716024-169716024 C>-	0.0	4301	MELANOMA	-	-	-	-	NOSTRIN	ENST00000317647,p.N352fs|ENST00000445023,p.N274fs|uc010fpu.3,p.N324fs|ENST00000458381,p.N409fs|ENST00000421711,p.N324fs|uc002ueg.3,p.N352fs|uc002ueh.3,p.N274fs|NM_001171631,p.N409fs|ENST00000397206,p.N274fs|NM_052946,p.N274fs|NM_001171632,p.N324fs|ENST00000397209,p.N324fs|ENST00000444448,p.N409fs|NM_001039724,p.N352fs|uc002uef.3,p.N409fs|uc002uek.3,p.N36fs	retained_intron, protein_coding, nonsense_mediated_decay	uc010fpu.3	frameshift deletion	exon12	c.972delC	p.N324fs	KSQKDTAALMDENNLKLDLLEANSY	KSQKDTAALMDEKI	8.0	1.0	-	-	4301_2:169716024-169716024 C>-_KSQKDTAALMDEKI	0.0
7:7559731-7559731 G>A	0.0	3903	MELANOMA	-	-	-	-	COL28A1	ENST00000399429,p.P259S|NM_001037763,p.P259S|uc003src.1,p.P259S	retained_intron, protein_coding, nonsense_mediated_decay	uc003src.1	nonsynonymous SNV	exon6	c.C775T	p.P259S	PGDPGPPGTHGNPGIKGERGPKGNP	PGDPGPPGTHGNSGIKGERGPKGNP	3.0	1.0	-	-	3903_7:7559731-7559731 G>A_PGDPGPPGTHGNSGIKGERGPKGNP	0.0
12:57962767-57962767 G>A	0.0	4301	MELANOMA	-	-	-	-	KIF5A	uc001sor.1,p.G246R|ENST00000455537,p.G246R|uc010srr.1,p.G157R|ENST00000286452,p.G157R|NM_004984,p.G246R	retained_intron, protein_coding	uc010srr.1	nonsynonymous SNV	exon6	c.G469A	p.G157R	AGSEKVSKTGAEGAVLDEAKNINKS	AGSEKVSKTGAERAVLDEAKNINKS	3.0	7.0	-	-	4301_12:57962767-57962767 G>A_AGSEKVSKTGAERAVLDEAKNINKS	0.0
X:152815031-152815031 C>A	0.0	4246	COLORECTAL	-	-	-	1	ATP2B3	ENST00000370181,p.S458Y|ENST00000263519,p.S472Y|NM_021949,p.S472Y|uc004fhs.1,p.S472Y|ENST00000359149,p.S472Y|ENST00000370186,p.S458Y|NM_001001344,p.S472Y|ENST00000349466,p.S472Y|uc004fht.1,p.S472Y|ENST00000393842,p.S458Y	protein_coding, processed_transcript	uc004fht.1	nonsynonymous SNV	exon9	c.C1415A	p.S472Y	ACETMGNATAICSDKTGTLTTNRMT	ACETMGNATAICYDKTGTLTTNRMT	3.0	3.0	-	-	4246_X:152815031-152815031 C>A_ACETMGNATAICYDKTGTLTTNRMT	0.0
15:58853128-58853128 A>C	1.0	4046	OVARIAN	-	-	-	-	LIPC	uc010bga.2,p.T373P|ENST00000433326,p.T312P|ENST00000356113,p.T373P|uc002afa.2,p.T373P|ENST00000299022,p.T373P|ENST00000414170,p.T373P|uc010bfz.1,p.T373P|NM_000236,p.T373P|uc010ugy.2,p.T312P|uc010bgb.1,p.T271P	retained_intron, protein_coding	uc010ugy.2	nonsynonymous SNV	exon6	c.A934C	p.T312P	INQTETPIQTTFTMSLLGTKEKMQK	INQTETPIQTTFPMSLLGTKEKMQK	4.0	3.0	-	-	4046_15:58853128-58853128 A>C_INQTETPIQTTFPMSLLGTKEKMQK	0.0
16:23226601-23226601 C>A	0.0	4252	COLORECTAL	-	-	-	-	SCNN1G	ENST00000300061,p.S587R|uc002dlm.1,p.S587R|NM_001039,p.S587R	protein_coding	uc002dlm.1	nonsynonymous SNV	exon13	c.C1761A	p.S587R	WKQAPPCPEAPRSPQGQDNPALDID	WKQAPPCPEAPRRPQGQDNPALDID	4.0	9.0	-	-	4252_16:23226601-23226601 C>A_WKQAPPCPEAPRRPQGQDNPALDID	0.0
19:56467408-56467408 G>A	0.0	4177	PANCREATIC	-	-	-	-	NLRP8	ENST00000291971,p.V662I|ENST00000590542,p.V662I|NM_176811,p.V662I|uc002qmh.3,p.V662I|uc010etg.3,p.V662I	protein_coding	uc010etg.3	nonsynonymous SNV	exon3	c.G1984A	p.V662I	KRCQYLHEVELTVTLNFMNVWKLSS	KRCQYLHEVELTITLNFMNVWKLSS	1.0	8.0	-	-	4177_19:56467408-56467408 G>A_KRCQYLHEVELTITLNFMNVWKLSS	0.0
16:29845289-29845289 T>C	1.0	4258	ENDOMETRIAL	-	-	-	-	MVP	ENST00000563915,p.V160A|NM_001293204,p.V160A|NM_001293205,p.V160A|NM_017458,p.V160A|ENST00000395353,p.V160A|uc002duj.3,p.V160A|NM_005115,p.V160A|ENST00000357402,p.V160A|uc002dui.3,p.V160A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002duj.3	nonsynonymous SNV	exon5	c.T479C	p.V160A	PGTYIPRKEVEVVEIIQATIIRQNQ	PGTYIPRKEVEVAEIIQATIIRQNQ	10.0	3.0	-	-	4258_16:29845289-29845289 T>C_PGTYIPRKEVEVAEIIQATIIRQNQ	0.0
16:615053-615053 G>A	0.0	4158	COLORECTAL	-	-	-	-	PRR35	NM_145270,p.E488K|ENST00000409413,p.E488K|uc002chk.3,p.E488K	protein_coding	uc002chk.3	nonsynonymous SNV	exon3	c.G1462A	p.E488K	GPQALGEAWGRPELGPVLTGGTPEP	GPQALGEAWGRPKLGPVLTGGTPEP	1.0	10.0	-	-	4158_16:615053-615053 G>A_GPQALGEAWGRPKLGPVLTGGTPEP	0.0
6:28402433-28402433 G>A	1.0	3678	MELANOMA	-	-	-	-	ZSCAN23	ENST00000289788,p.H327Y|NM_001012455,p.H327Y|uc003nli.4,p.H327Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc003nli.4	nonsynonymous SNV	exon4	c.C979T	p.H327Y	SQNAGLFHHLRIHTGEKPYQCNQCN	SQNAGLFHHLRIYTGEKPYQCNQCN	5.0	3.0	-	-	3678_6:28402433-28402433 G>A_SQNAGLFHHLRIYTGEKPYQCNQCN	0.0
9:32541506-32541506 G>A	1.0	3716	MELANOMA	-	-	-	-	TOPORS	NM_001195622,p.S941F|NM_005802,p.S1006F|ENST00000360538,p.S1006F|ENST00000379858,p.S941F|uc003zrb.3,p.S1006F|uc003zrc.3,p.S941F	protein_coding	uc003zrc.3	nonsynonymous SNV	exon2	c.C2822T	p.S941F	QTLDVREESTFVSDLENQPSNIVSL	QTLDVREESTFVFDLENQPSNIVSL	8.0	7.0	-	-	3716_9:32541506-32541506 G>A_QTLDVREESTFVFDLENQPSNIVSL	0.0
5:161569200-161569200 A>T	0.0	4266	COLORECTAL	-	-	-	-	GABRG2	uc003lyz.4,p.D267V|ENST00000356592,p.D267V|uc003lyy.4,p.D267V|NM_198903,p.D307V|uc010jjc.3,p.D307V|NM_198904,p.D267V|NM_000816,p.D267V|ENST00000393933,p.D172V|ENST00000522053,p.D172V|ENST00000361925,p.D267V|ENST00000414552,p.D307V|uc011dej.2,p.D172V	protein_coding, nonsense_mediated_decay	uc011dej.2	nonsynonymous SNV	exon8	c.A515T	p.D172V	TSGDYVVMSVYFDLSRRMGYFTIQT	TSGDYVVMSVYFVLSRRMGYFTIQT	1.0	2.0	-	-	4266_5:161569200-161569200 A>T_TSGDYVVMSVYFVLSRRMGYFTIQT	0.0
18:6824798-6824798 C>T	0.0	4155	MELANOMA	-	-	-	-	LINC01387,ARHGAP28	ENST00000583410,p.L19F|ENST00000584387,p.L27F|ENST00000400091,p.L54F|ENST00000383472,p.L54F	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000584387	nonsynonymous SNV	exon2	c.C79T	p.L27F	KSIPRCRRINRMLSNESLHPPAFSR	KSIPRCRRINRMFSNESLHPPAFSR	5.0	5.0	-	-	4155_18:6824798-6824798 C>T_KSIPRCRRINRMFSNESLHPPAFSR	0.0
X:144904117-144904117 ->C	0.0	4177	PANCREATIC	-	-	ID=COSM1466167;OCCURENCE=1(large_intestine)	-	SLITRK2	uc010nso.3,p.Q58fs|uc011mws.2,p.Q58fs|uc011mwt.2,p.Q58fs|ENST00000370490,p.Q58fs|uc011mwr.2,p.Q58fs|uc004fcg.3,p.Q58fs|NM_032539,p.Q58fs|NM_001144009,p.Q58fs|ENST00000335565,p.Q58fs|uc022cfn.1,p.Q58fs|NM_001144010,p.Q58fs|ENST00000428560,p.Q58fs|ENST00000434188,p.Q58fs|NM_001144006,p.Q58fs|uc010nsp.3,p.Q58fs|uc004fcd.3,p.Q58fs|uc011mwq.2,p.Q58fs|NM_001144003,p.Q58fs|NM_001144005,p.Q58fs|NM_001144004,p.Q58fs|NM_001144008,p.Q58fs|ENST00000447897,p.Q58fs|ENST00000413937,p.Q58fs	protein_coding	uc022cfn.1	frameshift insertion	exon1	c.175dupC	p.Q58fs	CENKGFTTVSLLQPPQYRIYQLFLN	CENKGFTTVSLLQPPPVSNLSAFSQWKPLDKTVSKRICQLLQRGDSSPR	1.0	9.0	-	-	4177_X:144904117-144904117 ->C_CENKGFTTVSLLQPPPVSNLSAFSQWKPLDKTVSKRICQLLQRGDSSPR	0.0
11:71850855-71850855 C>T	0.0	3919	MELANOMA	-	-	-	-	FOLR3	ENST00000456237,p.R282C|ENST00000442948,p.R239C|uc001ory.1,p.R282C|ENST00000445078,p.R280C	retained_intron, protein_coding, nonsense_mediated_decay	uc001ory.1	nonsynonymous SNV	exon5	c.C844T	p.R282C	FYAAAMNAGAPSRGIIDS	FYAAAMNAGAPSCGIIDS	1.0	9.0	-	-	3919_11:71850855-71850855 C>T_FYAAAMNAGAPSCGIIDS	0.0
1:100353574-100353574 C>T	1.0	3713	MELANOMA	-	-	-	-	AGL	ENST00000294724,p.L908F|uc001dsn.1,p.L891F|NM_000642,p.L908F|uc001dsk.1,p.L908F|NM_000645,p.L891F|NM_000643,p.L908F|uc001dsi.1,p.L908F|ENST00000370165,p.L908F|ENST00000370163,p.L908F|ENST00000361915,p.L908F|ENST00000361522,p.L891F|uc001dsl.1,p.L908F|uc001dsj.1,p.L908F|NM_000646,p.L892F|NM_000028,p.L908F|ENST00000361302,p.L892F|uc001dsm.1,p.L892F|ENST00000370161,p.L892F|NM_000644,p.L908F	protein_coding, processed_transcript	uc001dsn.1	nonsynonymous SNV	exon19	c.C2671T	p.L891F	ASRLTLAELNQILYRCESEEKEDGG	ASRLTLAELNQIFYRCESEEKEDGG	4.0	8.0	-	-	3713_1:100353574-100353574 C>T_ASRLTLAELNQIFYRCESEEKEDGG	0.0
1:173506133-173506133 C>A	0.0	4213	COLORECTAL	-	-	-	-	SLC9C2	ENST00000367714,p.A535S|uc009wwe.2,p.A93S|NM_178527,p.A535S|uc001giz.2,p.A535S|ENST00000536496,p.A433S	protein_coding, processed_transcript	uc009wwe.2	nonsynonymous SNV	exon7	c.G277T	p.A93S	EKQRNNGILEIEAARILIGAAKCYY	EKQRNNGILEIESARILIGAAKCYY	2.0	3.0	-	-	4213_1:173506133-173506133 C>A_EKQRNNGILEIESARILIGAAKCYY	0.0
12:111356916-111356916 A>T	0.0	2591	MELANOMA	-	-	-	-	MYL2	ENST00000228841,p.F29I|uc001try.4,p.F29I|NM_000432,p.F29I	retained_intron, protein_coding	uc001try.4	nonsynonymous SNV	exon2	c.T85A	p.F29I	VFSMFEQTQIQEFKEAFTIMDQNRD	VFSMFEQTQIQEIKEAFTIMDQNRD	1.0	5.0	-	-	2591_12:111356916-111356916 A>T_VFSMFEQTQIQEIKEAFTIMDQNRD	0.0
1:152275873-152275873 T>A	0.0	4037	NSCLC	-	-	-	-	FLG	ENST00000368799,p.H3830L|NM_002016,p.H3830L|uc001ezu.1,p.H3830L	protein_coding	uc001ezu.1	nonsynonymous SNV	exon3	c.A11489T	p.H3830L	QSGDGSRHSGSRHHEASTQADSSRH	QSGDGSRHSGSRLHEASTQADSSRH	1.0	10.0	-	-	4037_1:152275873-152275873 T>A_QSGDGSRHSGSRLHEASTQADSSRH	0.0
5:90021044-90021044 T>G	0.0	3795	MELANOMA	-	-	-	-	GPR98	NM_032119,p.F3350V|ENST00000405460,p.F3350V|uc003kjv.3,p.F950V|uc003kju.3,p.F3350V	retained_intron, protein_coding, processed_transcript	uc003kjv.3	nonsynonymous SNV	exon15	c.T2848G	p.F950V	NSVFTFTSGFKLFLVQTIIILESSQ	NSVFTFTSGFKLVLVQTIIILESSQ	5.0	10.0	-	-	3795_5:90021044-90021044 T>G_NSVFTFTSGFKLVLVQTIIILESSQ	0.0
11:60173452-60173452 T>G	0.0	4258	ENDOMETRIAL	-	-	-	-	MS4A14	uc031qbe.1,p.S170A|NM_001261827,p.S170A|ENST00000531783,p.S187A|NM_001261828,p.S187A|uc031qbd.1,p.S187A	protein_coding, nonsense_mediated_decay	uc031qbe.1	nonsynonymous SNV	exon4	c.T508G	p.S170A	TIASFRSKCWTQSDEVLFFLPSDVT	TIASFRSKCWTQADEVLFFLPSDVT	5.0	5.0	-	-	4258_11:60173452-60173452 T>G_TIASFRSKCWTQADEVLFFLPSDVT	0.0
2:74460656-74460656 G>A	0.0	4155	MELANOMA	0.0027	-	-	-	SLC4A5	uc002skp.1,p.P721L|NM_021196,p.P823L|ENST00000394019,p.P823L|uc010ffc.1,p.P823L|uc002skn.3,p.P823L|ENST00000358683,p.P721L|ENST00000346834,p.P823L|uc002sks.1,p.P785L|uc002sko.1,p.P823L|ENST00000423644,p.P823L|ENST00000425249,p.P785L|ENST00000359484,p.P721L|ENST00000357822,p.P823L|ENST00000377634,p.P823L|ENST00000377632,p.P823L|NM_133478,p.P823L	retained_intron, protein_coding, processed_transcript	uc010ffc.1	nonsynonymous SNV	exon18	c.C2468T	p.P823L	KPTRPDRGWFVAPFGKNPWWVYPAS	KPTRPDRGWFVALFGKNPWWVYPAS	5.0	2.0	-	-	4155_2:74460656-74460656 G>A_KPTRPDRGWFVALFGKNPWWVYPAS	0.0
5:143853344-143853344 G>T	0.0	4284	COLORECTAL	-	-	-	-	KCTD16	ENST00000507359,p.Q318H|NM_020768,p.Q318H|uc003lnm.1,p.Q318H|uc003lnn.1,p.Q318H|ENST00000512467,p.Q318H	protein_coding	uc003lnn.1	nonsynonymous SNV	exon3	c.G954T	p.Q318H	SCNDLSTSSCDSQSEASSPQETVIC	SCNDLSTSSCDSHSEASSPQETVIC	2.0	1.0	-	-	4284_5:143853344-143853344 G>T_SCNDLSTSSCDSHSEASSPQETVIC	0.0
6:160218435-160218435 C>T	1.0	4240	BREAST	-	-	-	-	MRPL18	NM_014161,p.T119I|uc003qsw.4,p.T119I|ENST00000367034,p.T119I	protein_coding, processed_transcript	uc003qsw.4	nonsynonymous SNV	exon3	c.C356T	p.T119I	TREWAIKKHLYSTRNVVACESIGRV	TREWAIKKHLYSIRNVVACESIGRV	10.0	7.0	-	-	4240_6:160218435-160218435 C>T_TREWAIKKHLYSIRNVVACESIGRV	0.0
1:40097199-40097199 C>T	0.0	3903	MELANOMA	-	-	-	-	HEYL	uc001cdp.3,p.R67Q|ENST00000535435,p.R39Q|uc010oiw.2,p.R39Q|NM_014571,p.R67Q|ENST00000372852,p.R67Q	protein_coding	uc010oiw.2	nonsynonymous SNV	exon3	c.G116A	p.R39Q	RRDRINSSLSELRRLVPTAFEKQGS	RRDRINSSLSELQRLVPTAFEKQGS	7.0	3.0	-	-	3903_1:40097199-40097199 C>T_RRDRINSSLSELQRLVPTAFEKQGS	0.0
2:29011586-29011586 G>T	1.0	4284	COLORECTAL	-	-	-	-	PPP1CB	ENST00000358506,p.D219Y|uc002rmh.3,p.D219Y|uc010yml.2,p.D191Y|NM_206876,p.D219Y|uc010ymj.2,p.D191Y|NM_002709,p.D219Y|ENST00000296122,p.D219Y|uc002rmg.3,p.D219Y|ENST00000395366,p.D219Y	retained_intron, protein_coding, nonsense_mediated_decay	uc010yml.2	nonsynonymous SNV	exon6	c.G571T	p.D191Y	DPDKDVQGWGENDRGVSFTFGADVV	DPDKDVQGWGENYRGVSFTFGADVV	10.0	3.0	-	-	4284_2:29011586-29011586 G>T_DPDKDVQGWGENYRGVSFTFGADVV	0.0
16:57562989-57562989 G>T	1.0	4095	COLORECTAL	-	-	-	-	CCDC102A	uc002elw.3,p.P34H|NM_033212,p.P34H|ENST00000258214,p.P34H	retained_intron, protein_coding	uc002elw.3	nonsynonymous SNV	exon2	c.C101A	p.P34H	TILGSPSPERMGPADSLPPTPPSGT	TILGSPSPERMGHADSLPPTPPSGT	7.0	7.0	-	-	4095_16:57562989-57562989 G>T_TILGSPSPERMGHADSLPPTPPSGT	0.0
X:120008797-120008823 TCCTCTGTGGCCTCCTCTGTGAGCTTC>-	0.0	4316	COLORECTAL	-	-	ID=COSM111663;OCCURENCE=1(ovary),2(breast)	-	CT47B1	NM_001145718,p.234_243del|uc011muc.2,p.234_243del|ENST00000371311,p.234_243del	protein_coding	uc011muc.2	nonframeshift deletion	exon1	c.702_728del	p.234_243del	AADEKPPEEAAEEKLTEEATEEPAA	AADEKPPEEAAEEPAAEEPTSEEAV	1.0	10.0	-	-	4316_X:120008797-120008823 TCCTCTGTGGCCTCCTCTGTGAGCTTC>-_AADEKPPEEAAEEPAAEEPTSEEAV	0.0
1:93159879-93159879 G>A	1.0	4071	COLORECTAL	-	-	-	-	EVI5	uc010otf.2,p.L370F|uc001dox.3,p.L370F|ENST00000540033,p.L370F|ENST00000543509,p.L370F|ENST00000370331,p.L370F|NM_005665,p.L370F	protein_coding, processed_transcript	uc010otf.2	nonsynonymous SNV	exon8	c.C1108T	p.L370F	ALLQMNQAELMQLDMEGMLQHFQKV	ALLQMNQAELMQFDMEGMLQHFQKV	8.0	5.0	-	-	4071_1:93159879-93159879 G>A_ALLQMNQAELMQFDMEGMLQHFQKV	0.0
3:169985714-169985714 C>A	1.0	4037	NSCLC	-	-	-	-	PRKCI	NM_002740,p.R126S|uc003fgs.2,p.R126S|ENST00000295797,p.R126S	retained_intron, protein_coding	uc003fgs.2	nonsynonymous SNV	exon5	c.C376A	p.R126S	GMPCPGEDKSIYRRGARRWRKLYCA	GMPCPGEDKSIYSRGARRWRKLYCA	9.0	8.0	-	-	4037_3:169985714-169985714 C>A_GMPCPGEDKSIYSRGARRWRKLYCA	0.0
8:38677960-38677960 C>T	1.0	4326	BREAST	-	-	-	-	TACC1	ENST00000443286,p.H416Y|ENST00000518415,p.H355Y|uc003xmb.4,p.H355Y|uc010lwq.3,p.H205Y|uc010lwp.3,p.H400Y|ENST00000520615,p.H205Y|uc011lcc.2,p.H205Y|ENST00000522904,p.H372Y|ENST00000519416,p.H205Y|NM_006283,p.H400Y|uc011lbz.2,p.H416Y|uc011lcb.2,p.H205Y|uc011lby.1,p.H205Y|uc003xmh.4,p.H205Y|uc003xlz.3,p.H205Y|ENST00000317827,p.H400Y|uc003xmc.4,p.H205Y|NM_001146216,p.H205Y|ENST00000520973,p.H205Y|ENST00000520340,p.H364Y|ENST00000379931,p.H400Y|uc011lca.2,p.H400Y	retained_intron, protein_coding, processed_transcript	uc011lcc.2	nonsynonymous SNV	exon2	c.C613T	p.H205Y	QWESPSFNPFGSHSVLQNSPPLSSE	QWESPSFNPFGSYSVLQNSPPLSSE	9.0	3.0	-	-	4326_8:38677960-38677960 C>T_QWESPSFNPFGSYSVLQNSPPLSSE	0.0
21:37586812-37586812 C>T	1.0	3713	MELANOMA	-	-	-	-	DOPEY2	uc002yvg.3,p.P363S|NM_005128,p.P363S|ENST00000399151,p.P363S|uc011aeb.2,p.P363S	retained_intron, protein_coding, processed_transcript	uc011aeb.2	nonsynonymous SNV	exon8	c.C1087T	p.P363S	ADVEERHHAYLKPFRVLISLLDKPE	ADVEERHHAYLKSFRVLISLLDKPE	4.0	8.0	-	-	3713_21:37586812-37586812 C>T_ADVEERHHAYLKSFRVLISLLDKPE	0.0
8:72182030-72182030 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	EYA1	uc003xyv.3,p.T210K|NM_172059,p.T327K|uc003xys.4,p.T332K|NM_172060,p.T299K|NM_172058,p.T332K|NM_000503,p.T332K|uc003xyt.4,p.T299K|uc003xyr.4,p.T327K|ENST00000388742,p.T332K|ENST00000388740,p.T299K|uc010lzf.3,p.T259K|ENST00000388741,p.T298K|ENST00000340726,p.T332K|uc003xyu.3,p.T332K|NM_001288575,p.T210K|ENST00000388743,p.T331K|ENST00000303824,p.T326K|ENST00000419131,p.T327K|uc011lfe.2,p.T326K|NM_001288574,p.T326K	retained_intron, protein_coding, nonsense_mediated_decay	uc011lfe.2	nonsynonymous SNV	exon11	c.C977A	p.T326K	DLERVFIWDLDETIIVFHSLLTGSY	DLERVFIWDLDEKIIVFHSLLTGSY	2.0	3.0	-	-	4258_8:72182030-72182030 G>T_DLERVFIWDLDEKIIVFHSLLTGSY	0.0
7:45009658-45009658 T>C	0.0	4329	COLORECTAL	-	-	-	-	MYO1G	uc010kym.2,p.E323G|ENST00000258787,p.E438G|NM_033054,p.E438G|uc003tmh.2,p.E438G|uc003tmg.2,p.E200G|uc003tmi.1,p.E350G|uc003tmj.2,p.E200G	retained_intron, protein_coding, nonsense_mediated_decay	uc010kym.2	nonsynonymous SNV	exon9	c.A968G	p.E323G	LILKQEQEEYEREGITWQSVEYFNN	LILKQEQEEYERGGITWQSVEYFNN	5.0	4.0	-	-	4329_7:45009658-45009658 T>C_LILKQEQEEYERGGITWQSVEYFNN	0.0
X:123699239-123699239 T>A	1.0	4196	COLORECTAL	-	-	-	-	TENM1	uc004euj.3,p.D750V|NM_001163279,p.D749V|uc010nqy.3,p.D750V|ENST00000371130,p.D750V|ENST00000422452,p.D750V|NM_001163278,p.D750V|NM_014253,p.D750V|uc011muj.2,p.D749V	protein_coding, processed_transcript	uc011muj.2	nonsynonymous SNV	exon12	c.A2246T	p.D749V	DGKCECSPGWEGDHCTIAHYLDAVR	DGKCECSPGWEGVHCTIAHYLDAVR	4.0	10.0	-	-	4196_X:123699239-123699239 T>A_DGKCECSPGWEGVHCTIAHYLDAVR	0.0
5:140750194-140750194 G>A	0.0	4077	BILE DUCT	-	-	-	-	PCDHGB3	uc011dat.2,p.S78N|NM_032097,p.S78N|NM_018924,p.S78N|uc003ljw.2,p.S78N|ENST00000576222,p.S78N	protein_coding	uc011dat.2	nonsynonymous SNV	exon1	c.G233A	p.S78N	LRVIAEKKFFTVSPENGNLLVSDRI	LRVIAEKKFFTVNPENGNLLVSDRI	3.0	5.0	-	-	4077_5:140750194-140750194 G>A_LRVIAEKKFFTVNPENGNLLVSDRI	0.0
11:26702641-26702641 G>A	0.0	4301	MELANOMA	-	-	-	-	SLC5A12	NM_178498,p.S479L|ENST00000396005,p.S479L|uc001mra.2,p.S479L	retained_intron, protein_coding, nonsense_mediated_decay	uc001mra.2	nonsynonymous SNV	exon12	c.C1436T	p.S479L	WPLPLSTDQCIKSNVTATGPPVLSS	WPLPLSTDQCIKLNVTATGPPVLSS	2.0	7.0	-	-	4301_11:26702641-26702641 G>A_WPLPLSTDQCIKLNVTATGPPVLSS	0.0
X:78619014-78619014 G>C	1.0	4234	NSCLC	-	-	-	-	ITM2A	ENST00000373298,p.S50C|uc004edh.3,p.S50C|NM_004867,p.S50C	protein_coding, processed_transcript	uc004edh.3	nonsynonymous SNV	exon2	c.C149G	p.S50C	ELRVATQEKEGSSGRCMLTLLGLSF	ELRVATQEKEGSCGRCMLTLLGLSF	8.0	2.0	-	-	4234_X:78619014-78619014 G>C_ELRVATQEKEGSCGRCMLTLLGLSF	0.0
6:31749703-31749703 A>C	1.0	2556	MELANOMA	-	-	-	-	VARS	NM_006295,p.S756R|ENST00000375663,p.S756R|uc003nxe.3,p.S756R	retained_intron, protein_coding, processed_transcript	uc003nxe.3	nonsynonymous SNV	exon19	c.T2268G	p.S756R	PPGEDPDGRYWVSGRNEAEAREKAA	PPGEDPDGRYWVRGRNEAEAREKAA	10.0	3.0	-	-	2556_6:31749703-31749703 A>C_PPGEDPDGRYWVRGRNEAEAREKAA	0.0
19:44130381-44130381 G>A	1.0	3713	MELANOMA	-	-	-	-	CADM4	uc002oxc.1,p.R187C|ENST00000222374,p.R187C|NM_145296,p.R187C	protein_coding, processed_transcript	uc002oxc.1	nonsynonymous SNV	exon5	c.C559T	p.R187C	GKVWSVASTVRFRVDRKDDGGIIIC	GKVWSVASTVRFCVDRKDDGGIIIC	2.0	10.0	-	-	3713_19:44130381-44130381 G>A_GKVWSVASTVRFCVDRKDDGGIIIC	0.0
2:137814206-137814206 A>T	0.0	4186	BREAST	-	-	-	-	THSD7B	uc002tva.1,p.Y88F|ENST00000413152,p.Y88F|ENST00000272643,p.Y119F|ENST00000409968,p.Y119F	retained_intron, protein_coding, processed_transcript	uc002tva.1	nonsynonymous SNV	exon2	c.A263T	p.Y88F	EVSDWHHCVLVPYARGEVKPRTAEC	EVSDWHHCVLVPFARGEVKPRTAEC	2.0	5.0	-	-	4186_2:137814206-137814206 A>T_EVSDWHHCVLVPFARGEVKPRTAEC	0.0
2:162273046-162273046 C>G	0.0	4186	BREAST	-	-	-	-	TBR1	ENST00000389554,p.T42S|uc002ubw.1,p.T42S|NM_006593,p.T42S	retained_intron, protein_coding, processed_transcript	uc002ubw.1	nonsynonymous SNV	exon1	c.C125G	p.T42S	SELVLHDHPIISTTDNLERSSPLKK	SELVLHDHPIISSTDNLERSSPLKK	1.0	6.0	-	-	4186_2:162273046-162273046 C>G_SELVLHDHPIISSTDNLERSSPLKK	0.0
1:114354681-114354681 G>T	1.0	4258	ENDOMETRIAL	-	-	-	-	RSBN1	NM_018364,p.S118R|ENST00000261441,p.S118R|uc001edq.3,p.S118R	protein_coding, processed_transcript, nonsense_mediated_decay	uc001edq.3	nonsynonymous SNV	exon1	c.C354A	p.S118R	EPPLAPPHRRRRSRQHPGPLPPTNA	EPPLAPPHRRRRRRQHPGPLPPTNA	7.0	6.0	-	-	4258_1:114354681-114354681 G>T_EPPLAPPHRRRRRRQHPGPLPPTNA	0.0
6:33177533-33177533 C>T	1.0	3919	MELANOMA	-	-	-	-	RING1	uc003odl.3,p.S41F|ENST00000374656,p.S70F|NM_002931,p.S70F|uc011dqx.1,p.S70F|uc003odk.3,p.S70F	protein_coding, processed_transcript	uc011dqx.1	nonsynonymous SNV	exon3	c.C209T	p.S70F	TMTTKECLHRFCSDCIVTALRSGNK	TMTTKECLHRFCFDCIVTALRSGNK	7.0	4.0	-	-	3919_6:33177533-33177533 C>T_TMTTKECLHRFCFDCIVTALRSGNK	0.0
9:43625701-43625701 G>T	0.0	4259	COLORECTAL	-	-	-	-	SPATA31A6	uc011lrb.2,p.P996T|ENST00000332857,p.P996T|NM_001145196,p.P996T	protein_coding, processed_transcript	uc011lrb.2	nonsynonymous SNV	exon4	c.C2986A	p.P996T	SSLHPRVSVSQDPRKLCLMEEVVSE	SSLHPRVSVSQDTRKLCLMEEVVSE	1.0	3.0	-	-	4259_9:43625701-43625701 G>T_SSLHPRVSVSQDTRKLCLMEEVVSE	0.0
3:53856534-53856534 T>C	1.0	4346	COLORECTAL	-	-	-	-	CHDH	NM_018397,p.N280S|ENST00000315251,p.N280S|uc003dgz.3,p.N280S	protein_coding	uc003dgz.3	nonsynonymous SNV	exon4	c.A839G	p.N280S	EGTRAVGVEYVKNGQSHRAYASKEV	EGTRAVGVEYVKSGQSHRAYASKEV	6.0	8.0	CD8	-	4346_3:53856534-53856534 T>C_EGTRAVGVEYVKSGQSHRAYASKEV	1.0
6:47680331-47680331 G>A	1.0	4329	COLORECTAL	0.0005	-	-	-	GPR115	uc003oyz.1,p.R237Q|uc003oza.1,p.R180Q|ENST00000327753,p.R180Q|NM_153838,p.R180Q|ENST00000371220,p.R237Q|uc003ozb.1,p.R180Q|ENST00000283303,p.R180Q	protein_coding	uc003ozb.1	nonsynonymous SNV	exon5	c.G539A	p.R180Q	KNISTDLSDNVTREKMKSYSEVANH	KNISTDLSDNVTQEKMKSYSEVANH	5.0	9.0	-	-	4329_6:47680331-47680331 G>A_KNISTDLSDNVTQEKMKSYSEVANH	0.0
11:85447646-85447646 G>A	1.0	4000	MELANOMA	-	-	-	-	SYTL2	uc010rtf.2,p.P19S|NM_032943,p.P161S|NM_001162951,p.P161S|ENST00000528231,p.P161S|uc001pbf.4,p.P161S|NM_001289608,p.P113S|ENST00000389960,p.P161S|uc010rti.2,p.P161S|ENST00000524452,p.P161S|uc010rth.2,p.P161S|ENST00000527523,p.P113S|uc010rtj.2,p.P113S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rtj.2	nonsynonymous SNV	exon5	c.C337T	p.P113S	RKPNVSPEKRKNPFNSSKLPEGHSS	RKPNVSPEKRKNSFNSSKLPEGHSS	10.0	9.0	-	-	4000_11:85447646-85447646 G>A_RKPNVSPEKRKNSFNSSKLPEGHSS	0.0
19:46032540-46032540 A>G	0.0	4110	BILE DUCT	-	-	-	-	OPA3	uc002pcj.4,p.L106S|ENST00000323060,p.L106S|NM_001017989,p.L106S	protein_coding	uc002pcj.4	nonsynonymous SNV	exon2	c.T317C	p.L106S	CSCLMLEYWRHQLQQRRKEKERRVA	CSCLMLEYWRHQSQQRRKEKERRVA	6.0	7.0	-	-	4110_19:46032540-46032540 A>G_CSCLMLEYWRHQSQQRRKEKERRVA	0.0
1:205034250-205034250 G>A	0.0	4213	COLORECTAL	-	-	-	-	CNTN2	uc001hbs.3,p.D307N|ENST00000331830,p.D519N|uc001hbq.1,p.D410N|NM_005076,p.D519N|uc001hbr.3,p.D519N	retained_intron, protein_coding	uc001hbs.3	nonsynonymous SNV	exon8	c.G919A	p.D307N	DATKITLAPSSADINLGDNLTLQCH	DATKITLAPSSANINLGDNLTLQCH	2.0	5.0	-	-	4213_1:205034250-205034250 G>A_DATKITLAPSSANINLGDNLTLQCH	0.0
2:71909728-71909728 G>A	1.0	4278	COLORECTAL	-	-	ID=COSM1592373,COSM1022693;OCCURENCE=1(endometrium)	-	DYSF	uc010fei.3,p.R2059H|uc010fek.3,p.R2060H|ENST00000429174,p.R2063H|ENST00000409366,p.R2064H|NM_001130982,p.R2074H|ENST00000410020,p.R2081H|NM_001130977,p.R2049H|ENST00000409744,p.R2050H|uc010fem.3,p.R2064H|NM_001130981,p.R2080H|ENST00000410041,p.R2060H|ENST00000394120,p.R2043H|ENST00000409651,p.R2074H|NM_001130984,p.R2050H|ENST00000409582,p.R2080H|ENST00000409762,p.R2059H|uc010yqy.2,p.R923H|ENST00000413539,p.R2073H|NM_001130455,p.R2043H|NM_001130980,p.R2059H|NM_001130978,p.R2063H|NM_001130986,p.R2029H|uc010yqz.2,p.R803H|uc002sie.3,p.R2042H|NM_001130987,p.R2081H|NM_001130983,p.R2064H|uc002sif.3,p.R2043H|uc010fef.3,p.R2080H|uc010feg.3,p.R2073H|NM_003494,p.R2042H|uc010feo.3,p.R2074H|uc010fen.3,p.R2081H|uc002sig.4,p.R2028H|uc010fej.3,p.R2050H|uc010fee.3,p.R2063H|NM_001130979,p.R2073H|NM_001130976,p.R2028H|ENST00000258104,p.R2042H|uc010fel.3,p.R2029H|NM_001130985,p.R2060H|uc010feh.3,p.R2049H	protein_coding, processed_transcript	uc010yqz.2	nonsynonymous SNV	exon21	c.G2408A	p.R803H	SPYKTMKFILWRRFRWAIILFIILF	SPYKTMKFILWRHFRWAIILFIILF	7.0	10.0	-	-	4278_2:71909728-71909728 G>A_SPYKTMKFILWRHFRWAIILFIILF	0.0
11:67161010-67161010 C>T	1.0	4158	COLORECTAL	-	-	-	-	RAD9A	uc001okr.3,p.T93M|NM_004584,p.T93M|ENST00000542139,p.T93M|NM_001243224,p.T17M|ENST00000307980,p.T93M|uc021qmg.1,p.T17M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qmg.1	nonsynonymous SNV	exon1	c.C50T	p.T17M	LSVFRSLAMLEKTVEKCCISLNGRS	LSVFRSLAMLEKMVEKCCISLNGRS	9.0	5.0	-	-	4158_11:67161010-67161010 C>T_LSVFRSLAMLEKMVEKCCISLNGRS	0.0
2:80529464-80529464 G>C	0.0	4213	COLORECTAL	-	-	-	-	LRRTM1	uc002sok.1,p.P494R|ENST00000433224,p.P494R|ENST00000295057,p.P494R|ENST00000409148,p.P494R|ENST00000417012,p.P494R|uc021vjt.1,p.P494R|NM_178839,p.P494R	protein_coding, nonsense_mediated_decay	uc021vjt.1	nonsynonymous SNV	exon1	c.C1481G	p.P494R	AMSAQEYYVDYKPNHIEGALVIINE	AMSAQEYYVDYKRNHIEGALVIINE	3.0	3.0	-	-	4213_2:80529464-80529464 G>C_AMSAQEYYVDYKRNHIEGALVIINE	0.0
22:32179902-32179902 C>T	1.0	3879	MELANOMA	-	-	ID=COSM1415903,COSM1415904;OCCURENCE=1(large_intestine)	-	DEPDC5	ENST00000400246,p.R165C|NM_014662,p.R165C|ENST00000266091,p.R165C|uc011alt.2,p.R137C|ENST00000400248,p.R165C|ENST00000382111,p.R165C|NM_001242896,p.R165C|uc003als.3,p.R165C|ENST00000535622,p.R165C|uc011als.2,p.R165C|ENST00000400249,p.R165C|ENST00000400242,p.R165C|ENST00000382105,p.R165C|NM_001007188,p.R165C|NM_001136029,p.R165C|ENST00000382112,p.R165C|uc003alt.3,p.R165C|uc003alr.2,p.R165C|NM_001242897,p.R165C|ENST00000536766,p.R137C|uc011alu.2,p.R165C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011alu.2	nonsynonymous SNV	exon9	c.C493T	p.R165C	CGYISEDTRVVFRSTSAMVYIFIQM	CGYISEDTRVVFCSTSAMVYIFIQM	8.0	5.0	-	-	3879_22:32179902-32179902 C>T_CGYISEDTRVVFCSTSAMVYIFIQM	0.0
4:13583868-13583868 G>A	1.0	3466	MELANOMA	-	-	-	-	BOD1L1	uc003gmz.1,p.S2862F|NM_148894,p.S2862F|ENST00000040738,p.S2862F	retained_intron, protein_coding, nonsense_mediated_decay	uc003gmz.1	nonsynonymous SNV	exon19	c.C8585T	p.S2862F	EKPEQNDDDTIKSQEEDQPIIIKRK	EKPEQNDDDTIKFQEEDQPIIIKRK	8.0	9.0	-	-	3466_4:13583868-13583868 G>A_EKPEQNDDDTIKFQEEDQPIIIKRK	0.0
7:154862986-154862986 C>T	0.0	4329	COLORECTAL	-	-	-	-	HTR5A	uc003wlt.2,p.V10M|ENST00000543018,p.V10M|ENST00000395731,p.V10M|uc011kvt.1,p.V10M	protein_coding, processed_transcript	uc011kvt.1	nonsynonymous SNV	exon1	c.G28A	p.V10M	MAVTFQMLAVQQSTSHAIQSWH	MAVTFQMLAMQQSTSHAIQSWH	1.0	6.0	-	-	4329_7:154862986-154862986 C>T_MAVTFQMLAMQQSTSHAIQSWH	0.0
4:144801564-144801564 C>A	0.0	4259	COLORECTAL	-	-	-	-	GYPE	ENST00000358615,p.G46W|uc003ijj.3,p.G46W|uc003ijk.4,p.G46W|NM_002102,p.G46W|NM_198682,p.G46W|ENST00000437468,p.G46W	protein_coding, nonsense_mediated_decay	uc003ijk.4	nonsynonymous SNV	exon2	c.G136T	p.G46W	SVTKSYISSQTNGITLINWWAMARV	SVTKSYISSQTNWITLINWWAMARV	2.0	2.0	-	-	4259_4:144801564-144801564 C>A_SVTKSYISSQTNWITLINWWAMARV	0.0
X:69720382-69720382 T>G	1.0	4244	COLORECTAL	-	-	-	-	DLG3	uc004dyj.2,p.L431R|NM_021120,p.L736R|ENST00000542398,p.L285R|NM_001166278,p.L285R|NM_020730,p.L431R|ENST00000194900,p.L768R|uc004dyi.2,p.L736R|uc011mpn.2,p.L285R|ENST00000374360,p.L736R|ENST00000374355,p.L431R	retained_intron, protein_coding, processed_transcript	uc011mpn.2	nonsynonymous SNV	exon10	c.T854G	p.L285R	SGNAIKRLQQAQLYPIAIFIKPKSI	SGNAIKRLQQAQRYPIAIFIKPKSI	9.0	6.0	CD8	-	4244_X:69720382-69720382 T>G_SGNAIKRLQQAQRYPIAIFIKPKSI	1.0
20:55758957-55758957 T>G	1.0	4252	COLORECTAL	-	-	-	-	BMP7	uc010gip.1,p.K260T|NM_001719,p.K260T|uc002xyc.3,p.K260T|ENST00000395863,p.K260T|ENST00000450594,p.K260T	retained_intron, protein_coding, processed_transcript	uc010gip.1	nonsynonymous SNV	exon4	c.A779C	p.K260T	SVETLDGQSINPKLAGLIGRHGPQN	SVETLDGQSINPTLAGLIGRHGPQN	7.0	6.0	-	-	4252_20:55758957-55758957 T>G_SVETLDGQSINPTLAGLIGRHGPQN	0.0
11:48238657-48238657 T>C	0.0	4196	COLORECTAL	-	-	-	-	OR4B1	NM_001005470,p.I99T|ENST00000309562,p.I99T|uc010rhs.2,p.I99T	protein_coding	uc010rhs.2	nonsynonymous SNV	exon1	c.T296C	p.I99T	IKTISLEGCLTQIFFFHFFGVAEIL	IKTISLEGCLTQTFFFHFFGVAEIL	3.0	9.0	-	-	4196_11:48238657-48238657 T>C_IKTISLEGCLTQTFFFHFFGVAEIL	0.0
8:28991588-28991588 G>A	1.0	3713	MELANOMA	-	-	-	-	KIF13B	uc003xhh.4,p.P918L|ENST00000524189,p.P918L|NM_015254,p.P918L	retained_intron, protein_coding, nonsense_mediated_decay	uc003xhh.4	nonsynonymous SNV	exon22	c.C2753T	p.P918L	EVDTSSSSVSKEPHCMVVFDHCNEF	EVDTSSSSVSKELHCMVVFDHCNEF	5.0	9.0	-	-	3713_8:28991588-28991588 G>A_EVDTSSSSVSKELHCMVVFDHCNEF	0.0
2:152496564-152496564 T>G	0.0	4335	COLORECTAL	-	-	-	-	NEB	uc002txu.3,p.K2899T|uc031rpp.1,p.K2899T|ENST00000397345,p.K2899T|NM_001271208,p.K2899T|ENST00000427231,p.K2899T|ENST00000409198,p.K2899T|ENST00000604864,p.K2899T|NM_004543,p.K2899T|ENST00000603639,p.K2899T|NM_001164507,p.K2899T|uc021vrc.1,p.K2899T|NM_001164508,p.K2899T|ENST00000172853,p.K2899T|uc010fnx.3,p.K2899T|uc021vrd.1,p.K2899T|uc021vrb.1,p.K2899T	retained_intron, protein_coding, processed_transcript	uc031rpp.1	nonsynonymous SNV	exon62	c.A8696C	p.K2899T	RQAYDLQSDNMYKSDLQWMRGIGWV	RQAYDLQSDNMYTSDLQWMRGIGWV	5.0	7.0	-	-	4335_2:152496564-152496564 T>G_RQAYDLQSDNMYTSDLQWMRGIGWV	0.0
8:73848852-73848852 C>A	0.0	4158	COLORECTAL	-	-	-	-	KCNB2	NM_004770,p.S421Y|uc003xzb.3,p.S421Y|ENST00000523207,p.S421Y	protein_coding	uc003xzb.3	nonsynonymous SNV	exon3	c.C1262A	p.S421Y	IALPIPIIVNNFSEFYKEQKRQEKA	IALPIPIIVNNFYEFYKEQKRQEKA	6.0	10.0	-	-	4158_8:73848852-73848852 C>A_IALPIPIIVNNFYEFYKEQKRQEKA	0.0
X:118222310-118222310 T>G	0.0	4186	BREAST	-	-	-	-	KIAA1210	uc004era.4,p.Q961H|NM_020721,p.Q961H|ENST00000402510,p.Q961H	protein_coding	uc004era.4	nonsynonymous SNV	exon11	c.A2883C	p.Q961H	HPFQPWVNPKVEQEVSSSPKSMAVE	HPFQPWVNPKVEHEVSSSPKSMAVE	1.0	10.0	-	-	4186_X:118222310-118222310 T>G_HPFQPWVNPKVEHEVSSSPKSMAVE	0.0
12:53096725-53096725 C>T	0.0	4235	COLORECTAL	-	-	-	-	KRT77	uc001saw.3,p.R165Q|ENST00000553168,p.R165Q|ENST00000341809,p.R165Q|NM_175078,p.R165Q	retained_intron, protein_coding, nonsense_mediated_decay	uc001saw.3	nonsynonymous SNV	exon1	c.G494A	p.R165Q	VDPEIQRIKTQEREQIMVLNNKFAS	VDPEIQRIKTQEQEQIMVLNNKFAS	1.0	6.0	-	-	4235_12:53096725-53096725 C>T_VDPEIQRIKTQEQEQIMVLNNKFAS	0.0
17:909378-909378 G>A	1.0	4158	COLORECTAL	-	-	-	-	ABR	ENST00000291107,p.P804L|NM_001092,p.P804L|NM_001256847,p.P292L|NM_021962,p.P841L|ENST00000543210,p.P292L|uc002fsd.4,p.P841L|uc010vqg.3,p.P623L|NM_001159746,p.P795L|uc002fse.4,p.P795L|uc010vqf.3,p.P292L|NM_001282149,p.P623L|ENST00000574437,p.P795L|ENST00000536794,p.P623L|uc002fsf.4,p.P378L|ENST00000544583,p.P795L|uc002fsg.4,p.P804L|ENST00000302538,p.P841L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, ambiguous_orf	uc010vqg.3	nonsynonymous SNV	exon18	c.C1868T	p.P623L	AQVQVLLYYLQHPPISFAELKRNTL	AQVQVLLYYLQHLPISFAELKRNTL	9.0	10.0	-	-	4158_17:909378-909378 G>A_AQVQVLLYYLQHLPISFAELKRNTL	0.0
2:204074016-204074016 T>C	1.0	4326	BREAST	-	-	-	-	NBEAL1	ENST00000414576,p.S572P|NM_001114132,p.S2557P|ENST00000449802,p.S2557P|uc002uzu.3,p.S52P|uc021vvj.1,p.S1191P|uc002uzt.3,p.S2557P	retained_intron, protein_coding, processed_transcript	uc021vvj.1	nonsynonymous SNV	exon24	c.T3571C	p.S1191P	LAISWEGHIVVYSSTEEKTTLKDKN	LAISWEGHIVVYPSTEEKTTLKDKN	8.0	10.0	-	-	4326_2:204074016-204074016 T>C_LAISWEGHIVVYPSTEEKTTLKDKN	0.0
9:98997810-98997810 C>T	1.0	4266	COLORECTAL	0.12	rs2066479	ID=COSM3764082;OCCURENCE=1(large_intestine)	-	HSD17B3	ENST00000375262,p.G239S|uc004awa.1,p.G289S|ENST00000375263,p.G289S|NM_000197,p.G289S|uc010msc.1,p.G239S	protein_coding, processed_transcript	uc010msc.1	nonsynonymous SNV	exon10	c.G715A	p.G239S	FLSLIPAWAFYSGAFQRLLLTHYVA	FLSLIPAWAFYSSAFQRLLLTHYVA	4.0	7.0	-	-	4266_9:98997810-98997810 C>T_FLSLIPAWAFYSSAFQRLLLTHYVA	0.0
16:67680638-67680638 A>T	0.0	4335	COLORECTAL	-	-	-	-	RLTPR	NM_001013838,p.E163V|uc010vjr.2,p.E163V|uc002etn.3,p.E163V|ENST00000545661,p.E163V|uc010cel.1,p.E163V|ENST00000334583,p.E163V	protein_coding	uc010vjr.2	nonsynonymous SNV	exon7	c.A488T	p.E163V	PCSPCGGFLETYEALCDYNGFPFRE	PCSPCGGFLETYVALCDYNGFPFRE	5.0	3.0	-	-	4335_16:67680638-67680638 A>T_PCSPCGGFLETYVALCDYNGFPFRE	0.0
11:123814011-123814011 G>A	0.0	4298	COLORECTAL	-	-	ID=COSM268142;OCCURENCE=1(large_intestine)	-	OR6T1	NM_001005187,p.R179C|ENST00000321252,p.R179C|uc010sab.2,p.R179C	protein_coding	uc010sab.2	nonsynonymous SNV	exon1	c.C535T	p.R179C	PFCGPNGIDHFFRDSWPLLRLSCGD	PFCGPNGIDHFFCDSWPLLRLSCGD	1.0	8.0	-	-	4298_11:123814011-123814011 G>A_PFCGPNGIDHFFCDSWPLLRLSCGD	0.0
7:147815357-147815357 A>G	0.0	4177	PANCREATIC	-	-	-	2	CNTNAP2	NM_014141,p.D844G|ENST00000361727,p.D844G|uc003weu.2,p.D844G	protein_coding, processed_transcript	uc003weu.2	nonsynonymous SNV	exon16	c.A2531G	p.D844G	PWGVFLENMGKEDFIKLELKSATEV	PWGVFLENMGKEGFIKLELKSATEV	2.0	6.0	-	-	4177_7:147815357-147815357 A>G_PWGVFLENMGKEGFIKLELKSATEV	0.0
4:79345550-79345550 G>A	1.0	3678	MELANOMA	-	-	-	-	FRAS1	NM_001166133,p.E1563K|ENST00000325942,p.E1563K|uc003hlb.2,p.E1563K|ENST00000264895,p.E1563K|NM_025074,p.E1563K|uc003hkw.3,p.E1563K	retained_intron, protein_coding, nonsense_mediated_decay	uc003hlb.2	nonsynonymous SNV	exon35	c.G4687A	p.E1563K	QELMAFSFAGLPESVKFHFTVSDGE	QELMAFSFAGLPKSVKFHFTVSDGE	6.0	2.0	-	-	3678_4:79345550-79345550 G>A_QELMAFSFAGLPKSVKFHFTVSDGE	0.0
2:101706776-101706776 C>T	1.0	4320	COLORECTAL	-	-	ID=COSM1398437,COSM1398438;OCCURENCE=1(large_intestine)	-	TBC1D8	uc010fiv.3,p.A60T|NM_001102426,p.A60T|ENST00000409318,p.A60T|uc010yvw.2,p.A60T|ENST00000376840,p.A60T	retained_intron, protein_coding, processed_transcript	uc010yvw.2	nonsynonymous SNV	exon2	c.G178A	p.A60T	ALDAVLDSNARVAPFRILLQVPGSQ	ALDAVLDSNARVTPFRILLQVPGSQ	7.0	9.0	CD8	-	4320_2:101706776-101706776 C>T_ALDAVLDSNARVTPFRILLQVPGSQ	1.0
4:121958399-121958399 G>T	0.0	3775	CERVICAL	-	-	-	-	NDNF	uc003idq.1,p.P243T|ENST00000379692,p.P243T|NM_024574,p.P243T	protein_coding, processed_transcript	uc003idq.1	nonsynonymous SNV	exon4	c.C727A	p.P243T	LSADDAFMMAPKPGLDFSPFDFAHF	LSADDAFMMAPKTGLDFSPFDFAHF	3.0	9.0	-	-	3775_4:121958399-121958399 G>T_LSADDAFMMAPKTGLDFSPFDFAHF	0.0
1:227081795-227081795 C>T	1.0	3466	MELANOMA	-	-	-	-	PSEN2	NM_000447,p.T387I|ENST00000472139,p.T243I|uc009xep.1,p.T386I|ENST00000391872,p.T420I|ENST00000340188,p.T354I|ENST00000366782,p.T420I|NM_012486,p.T386I|ENST00000422240,p.T386I|uc009xeo.1,p.T387I|ENST00000366783,p.T387I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009xep.1	nonsynonymous SNV	exon12	c.C1157T	p.T386I	GKAAATGSGDWNTTLACFVAILIGL	GKAAATGSGDWNITLACFVAILIGL	7.0	1.0	-	-	3466_1:227081795-227081795 C>T_GKAAATGSGDWNITLACFVAILIGL	0.0
11:58338132-58338132 G>A	1.0	3879	MELANOMA	-	-	-	-	LPXN	uc010rkk.2,p.P19S|ENST00000528489,p.P19S	retained_intron, protein_coding, nonsense_mediated_decay	uc010rkk.2	nonsynonymous SNV	exon2	c.C55T	p.P19S	WNAPPFRTVMNIPTQLLFPWISIPE	WNAPPFRTVMNISTQLLFPWISIPE	3.0	10.0	-	-	3879_11:58338132-58338132 G>A_WNAPPFRTVMNISTQLLFPWISIPE	0.0
3:129150388-129150388 G>A	0.0	3466	MELANOMA	-	-	-	-	MBD4	NM_001276273,p.H249Y|uc003emk.2,p.H249Y|NM_001276270,p.H561Y|ENST00000429544,p.H561Y|uc003emh.2,p.H567Y|NM_003925,p.H567Y|ENST00000249910,p.H567Y|ENST00000393278,p.H249Y|uc003emj.2,p.H561Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003emk.2	nonsynonymous SNV	exon7	c.C745T	p.H249Y	QVHPEDHKLNKYHDWLWENHEKLSL	QVHPEDHKLNKYYDWLWENHEKLSL	8.0	6.0	-	-	3466_3:129150388-129150388 G>A_QVHPEDHKLNKYYDWLWENHEKLSL	0.0
8:69058492-69058492 T>G	0.0	4278	COLORECTAL	-	-	-	1	PREX2	NM_024870,p.V1379G|uc003xxv.1,p.V1379G|ENST00000288368,p.V1379G	protein_coding, processed_transcript	uc003xxv.1	nonsynonymous SNV	exon34	c.T4136G	p.V1379G	TYQAEGSRQALKVYFYIDSYHFEQL	TYQAEGSRQALKGYFYIDSYHFEQL	6.0	1.0	-	-	4278_8:69058492-69058492 T>G_TYQAEGSRQALKGYFYIDSYHFEQL	0.0
5:40958300-40958300 C>T	0.0	3795	MELANOMA	-	-	-	-	C7	NM_000587,p.H476Y|ENST00000313164,p.H476Y|uc003jmh.3,p.H476Y	retained_intron, protein_coding, processed_transcript	uc003jmh.3	nonsynonymous SNV	exon11	c.C1426T	p.H476Y	GLATVEGTHCLCHCKPYTFGAACEQ	GLATVEGTHCLCYCKPYTFGAACEQ	4.0	10.0	-	-	3795_5:40958300-40958300 C>T_GLATVEGTHCLCYCKPYTFGAACEQ	0.0
13:23903559-23903559 A>C	0.0	4345	COLORECTAL	-	-	-	-	SACS	uc001uop.1,p.C537W|ENST00000423156,p.C374W|uc001uoq.1,p.C685W	protein_coding, processed_transcript	uc001uoq.1	nonsynonymous SNV	exon7	c.T2055G	p.C685W	GKLKMVAVLITSC	GKLKMVAVLITSW	4.0	2.0	-	-	4345_13:23903559-23903559 A>C_GKLKMVAVLITSW	0.0
10:50339739-50339739 C>A	0.0	4287	COLORECTAL	-	-	-	-	FAM170B	NM_001164484,p.E257D|ENST00000311787,p.E257D|uc001jhj.3,p.E257D	protein_coding	uc001jhj.3	nonsynonymous SNV	exon2	c.G771T	p.E257D	RAQGQAHDQQLEEEQSPSDNSECSR	RAQGQAHDQQLEDEQSPSDNSECSR	1.0	8.0	-	-	4287_10:50339739-50339739 C>A_RAQGQAHDQQLEDEQSPSDNSECSR	0.0
2:189957098-189957098 G>C	0.0	4234	NSCLC	-	-	-	-	COL5A2	ENST00000374866,p.Q169E|uc002uqk.3,p.Q169E|NM_000393,p.Q169E	retained_intron, protein_coding	uc002uqk.3	nonsynonymous SNV	exon7	c.C505G	p.Q169E	PQGIDGEPGVPGQPGAPGPPGHPSH	PQGIDGEPGVPGEPGAPGPPGHPSH	9.0	4.0	-	-	4234_2:189957098-189957098 G>C_PQGIDGEPGVPGEPGAPGPPGHPSH	0.0
12:111701572-111701572 C>A	0.0	4326	BREAST	-	-	-	-	CUX2	ENST00000261726,p.A77D|uc001tsb.2,p.A132D|uc001tsa.2,p.A77D|NM_015267,p.A77D|ENST00000397643,p.A137D	protein_coding, processed_transcript	uc001tsb.2	nonsynonymous SNV	exon5	c.C395A	p.A132D	APVLKSFQAEVVALSKRSQEAEAAF	APVLKSFQAEVVDLSKRSQEAEAAF	4.0	8.0	-	-	4326_12:111701572-111701572 C>A_APVLKSFQAEVVDLSKRSQEAEAAF	0.0
9:130566936-130566936 G>A	1.0	3713	MELANOMA	-	-	-	-	FPGS	uc011mal.1,p.E115K|ENST00000373245,p.E115K|NM_001288803,p.E115K|uc004bsi.1,p.E65K|NM_004957,p.E115K|ENST00000373247,p.E115K|NM_001018078,p.E65K|ENST00000431857,p.E65K|ENST00000423577,p.E65K|ENST00000373228,p.E115K|uc004bsg.1,p.E115K|ENST00000393706,p.E115K|ENST00000373225,p.E65K	protein_coding, processed_transcript	uc011mal.1	nonsynonymous SNV	exon4	c.G343A	p.E115K	GTKGKGSTCAFTECILRSYGLKTGF	GTKGKGSTCAFTKCILRSYGLKTGF	6.0	10.0	-	-	3713_9:130566936-130566936 G>A_GTKGKGSTCAFTKCILRSYGLKTGF	0.0
1:115256529-115256529 T>C	1.0	4189	MELANOMA	-	-	ID=COSM584;OCCURENCE=4(soft_tissue),3(ovary),4(endometrium),474(skin),7(breast),1(small_intestine),7(urinary_tract),7(adrenal_gland),1(liver),4(eye),2(pancreas),4(biliary_tract),49(large_intestine),5(central_nervous_system),49(NS),289(thyroid),12(lung),9(meninges),3(testis),69(haematopoietic_and_lymphoid_tissue)	1	NRAS	uc009wgu.3,p.Q61R|ENST00000369535,p.Q61R|NM_002524,p.Q61R	protein_coding	uc009wgu.3	nonsynonymous SNV	exon3	c.A182G	p.Q61R	ETCLLDILDTAGQEEYSAMRDQYMR	ETCLLDILDTAGREEYSAMRDQYMR	6.0	10.0	-	-	4189_1:115256529-115256529 T>C_ETCLLDILDTAGREEYSAMRDQYMR	0.0
17:42512485-42512485 C>T	0.0	4081	COLORECTAL	-	-	-	-	GPATCH8	ENST00000585614,p.R74H|ENST00000434000,p.R21H|uc010wiz.2,p.R21H|uc002igv.2,p.R21H|NM_001002909,p.R99H|ENST00000591680,p.R99H|uc002igw.2,p.R99H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wiz.2	nonsynonymous SNV	exon6	c.G62A	p.R21H	ELDYAEDATERRRVLEVEKEDTEEL	ELDYAEDATERRHVLEVEKEDTEEL	8.0	9.0	-	-	4081_17:42512485-42512485 C>T_ELDYAEDATERRHVLEVEKEDTEEL	0.0
9:139685838-139685838 C>A	1.0	4316	COLORECTAL	-	-	-	-	TMEM141	uc004cje.4,p.L6M|uc011meg.1,p.L6M|ENST00000290079,p.L6M|NM_032928,p.L6M	retained_intron, protein_coding, processed_transcript	uc011meg.1	nonsynonymous SNV	exon1	c.C16A	p.L6M	MVNLGLSRVDDAVAAKHP	MVNLGMSRVDDAVAAKHP	10.0	1.0	-	-	4316_9:139685838-139685838 C>A_MVNLGMSRVDDAVAAKHP	0.0
2:209113113-209113113 G>A	1.0	4134	NSCLC	-	-	ID=COSM28747;OCCURENCE=212(haematopoietic_and_lymphoid_tissue),3(NS),184(bone),106(central_nervous_system),1(prostate),3(large_intestine),33(biliary_tract),3(liver),6(skin),1(breast),11(soft_tissue),1(autonomic_ganglia)	1	IDH1	ENST00000345146,p.R132C|NM_001282386,p.R132C|NM_005896,p.R132C|ENST00000446179,p.R132C|ENST00000415913,p.R132C|uc002vcu.3,p.R132C|ENST00000415282,p.R132C|uc002vcs.3,p.R132C|uc002vct.3,p.R132C|NM_001282387,p.R132C	retained_intron, protein_coding	uc002vcu.3	nonsynonymous SNV	exon4	c.C394T	p.R132C	LVSGWVKPIIIGRHAYGDQYRATDF	LVSGWVKPIIIGCHAYGDQYRATDF	9.0	5.0	-	-	4134_2:209113113-209113113 G>A_LVSGWVKPIIIGCHAYGDQYRATDF	0.0
7:142562315-142562315 G>T	0.0	4196	COLORECTAL	-	-	-	-	EPHB6	uc011ksu.2,p.A253S|ENST00000392957,p.A253S|ENST00000442129,p.A253S|uc011kst.2,p.A253S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ksu.2	nonsynonymous SNV	exon7	c.G757T	p.A253S	SFPETQASGAGGASLVAAVGTCVAH	SFPETQASGAGGSSLVAAVGTCVAH	6.0	8.0	-	-	4196_7:142562315-142562315 G>T_SFPETQASGAGGSSLVAAVGTCVAH	0.0
X:111698812-111698812 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	ZCCHC16	ENST00000340433,p.S286T|NM_001004308,p.S286T|uc022cct.1,p.S286T|uc004epo.1,p.S286T	protein_coding	uc022cct.1	nonsynonymous SNV	exon1	c.T856A	p.S286T	QQETQLCLYCSQSGHFTRDCLAKRS	QQETQLCLYCSQTGHFTRDCLAKRS	1.0	10.0	-	-	4258_X:111698812-111698812 T>A_QQETQLCLYCSQTGHFTRDCLAKRS	0.0
16:1550629-1550629 C>T	0.0	4278	COLORECTAL	-	-	-	-	TELO2	ENST00000497339,p.R404C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000497339	nonsynonymous SNV	exon9	c.C1210T	p.R404C	KCRLDSSLPPVRRLGMIVQIQLRGR	KCRLDSSLPPVRCLGMIVQIQLRGR	7.0	8.0	-	-	4278_16:1550629-1550629 C>T_KCRLDSSLPPVRCLGMIVQIQLRGR	0.0
16:58617084-58617084 A>G	1.0	3466	MELANOMA	-	-	-	-	CNOT1	uc002enx.4,p.I270T|NM_206999,p.I270T|NM_001265612,p.I270T|ENST00000567188,p.I270T|ENST00000317147,p.I270T|ENST00000441024,p.I270T|ENST00000569240,p.I270T|NM_016284,p.I270T|uc002env.4,p.I270T|uc002enu.5,p.I270T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002enx.4	nonsynonymous SNV	exon9	c.T809C	p.I270T	FMQEVGYGFCASIEECRNIIVQFGV	FMQEVGYGFCASTEECRNIIVQFGV	10.0	2.0	-	-	3466_16:58617084-58617084 A>G_FMQEVGYGFCASTEECRNIIVQFGV	0.0
18:7080286-7080286 C>T	0.0	3903	MELANOMA	-	-	-	-	LAMA1	NM_005559,p.E78K|ENST00000389658,p.E78K|uc002knm.3,p.E78K	retained_intron, protein_coding	uc002knm.3	nonsynonymous SNV	exon2	c.G232A	p.E78K	CRICDGNSANPRERHPISHAIDGTN	CRICDGNSANPRKRHPISHAIDGTN	7.0	10.0	-	-	3903_18:7080286-7080286 C>T_CRICDGNSANPRKRHPISHAIDGTN	0.0
8:102631887-102631887 C>T	0.0	3903	MELANOMA	-	-	-	-	GRHL2	ENST00000395927,p.H391Y|ENST00000251808,p.H407Y|NM_024915,p.H407Y|uc010mbu.3,p.H407Y	retained_intron, protein_coding, processed_transcript	uc010mbu.3	nonsynonymous SNV	exon9	c.C1219T	p.H407Y	TYSYNNRSNKPIHRAYCQIKVFCDK	TYSYNNRSNKPIYRAYCQIKVFCDK	1.0	5.0	-	-	3903_8:102631887-102631887 C>T_TYSYNNRSNKPIYRAYCQIKVFCDK	0.0
8:24771520-24771520 G>A	0.0	4326	BREAST	-	-	-	-	NEFM	uc011lac.1,p.E72K|uc003xed.4,p.E72K|ENST00000437366,p.E72K|ENST00000221166,p.E72K|ENST00000518131,p.E72K|NM_005382,p.E72K	protein_coding, processed_transcript	uc011lac.1	nonsynonymous SNV	exon1	c.G214A	p.E72K	RLAYSSAMLSSAESSLDFSQSSSLL	RLAYSSAMLSSAKSSLDFSQSSSLL	3.0	4.0	-	-	4326_8:24771520-24771520 G>A_RLAYSSAMLSSAKSSLDFSQSSSLL	0.0
1:33402619-33402619 T>C	1.0	4180	BREAST	-	-	-	-	RNF19B	NM_001300826,p.I662V|ENST00000373456,p.I663V|uc010ohp.2,p.I662V|uc010oho.2,p.I663V|NM_153341,p.I663V|ENST00000235150,p.I662V	protein_coding	uc010ohp.2	nonsynonymous SNV	exon9	c.A1984G	p.I662V	KPWDISLAQPESIRSDLESSDAQSD	KPWDISLAQPESVRSDLESSDAQSD	10.0	9.0	-	-	4180_1:33402619-33402619 T>C_KPWDISLAQPESVRSDLESSDAQSD	0.0
15:56739085-56739085 C>T	0.0	4160	COLORECTAL	-	-	-	-	MNS1	ENST00000260453,p.R137K|NM_018365,p.R137K|uc002adr.2,p.R137K	retained_intron, protein_coding, processed_transcript	uc002adr.2	nonsynonymous SNV	exon4	c.G410A	p.R137K	EKKLKAAYMNKERAAQIAEKDAIKY	EKKLKAAYMNKEKAAQIAEKDAIKY	3.0	6.0	-	-	4160_15:56739085-56739085 C>T_EKKLKAAYMNKEKAAQIAEKDAIKY	0.0
5:41186207-41186207 G>A	0.0	4298	COLORECTAL	-	-	-	-	C6	ENST00000263413,p.R231C|NM_001115131,p.R231C|uc003jml.2,p.R231C|uc003jmk.3,p.R231C|ENST00000337836,p.R231C|NM_000065,p.R231C	retained_intron, protein_coding, processed_transcript	uc003jml.2	nonsynonymous SNV	exon6	c.C691T	p.R231C	KTVKSSRTSNPYRVPANLENVGFEV	KTVKSSRTSNPYCVPANLENVGFEV	3.0	6.0	-	-	4298_5:41186207-41186207 G>A_KTVKSSRTSNPYCVPANLENVGFEV	0.0
15:48762851-48762851 C>A	0.0	4275	COLORECTAL	-	-	-	-	FBN1	ENST00000316623,p.R1480I|NM_000138,p.R1480I|uc001zwx.2,p.R1480I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zwx.2	nonsynonymous SNV	exon36	c.G4439T	p.R1480I	FRCECEIGYELDRSGGNCTDVNECL	FRCECEIGYELDISGGNCTDVNECL	8.0	9.0	-	-	4275_15:48762851-48762851 C>A_FRCECEIGYELDISGGNCTDVNECL	0.0
13:61102975-61102975 A>G	1.0	4252	COLORECTAL	-	-	-	-	TDRD3	NM_030794,p.Q446R|ENST00000377881,p.Q446R|uc001via.3,p.Q446R|ENST00000377894,p.Q446R|NM_001146070,p.Q539R|NM_001146071,p.Q446R|uc001vib.4,p.Q445R|uc010aef.2,p.Q271R|uc010aeg.3,p.Q539R|uc001vhz.4,p.Q446R|ENST00000196169,p.Q446R|ENST00000535286,p.Q539R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010aeg.3	nonsynonymous SNV	exon11	c.A1616G	p.Q539R	DYNNQKRGKRESQTSIPDYFYDRKS	DYNNQKRGKRESRTSIPDYFYDRKS	8.0	7.0	-	-	4252_13:61102975-61102975 A>G_DYNNQKRGKRESRTSIPDYFYDRKS	0.0
8:113516066-113516066 C>T	0.0	4301	MELANOMA	-	-	-	2	CSMD3	ENST00000455883,p.R1575Q|ENST00000339701,p.R1019Q|NM_198123,p.R1679Q|NM_198124,p.R1639Q|uc011lhx.2,p.R1575Q|uc003ynu.3,p.R1679Q|ENST00000343508,p.R1639Q|NM_052900,p.R1575Q|ENST00000297405,p.R1679Q|uc003ynt.3,p.R1639Q|ENST00000352409,p.R1679Q|uc003yns.3,p.R951Q	retained_intron, protein_coding, processed_transcript	uc011lhx.2	nonsynonymous SNV	exon29	c.G4724A	p.R1575Q	IESSSNTMHLAFRSDGSVSYTGFHL	IESSSNTMHLAFQSDGSVSYTGFHL	1.0	7.0	-	-	4301_8:113516066-113516066 C>T_IESSSNTMHLAFQSDGSVSYTGFHL	0.0
14:53513647-53513647 C>G	1.0	4244	COLORECTAL	-	-	-	-	DDHD1	ENST00000323669,p.D848H|uc001xai.3,p.D848H|NM_001160148,p.D848H	retained_intron, protein_coding, processed_transcript	uc001xai.3	nonsynonymous SNV	exon13	c.G2542C	p.D848H	KDNALVELDHRIDFELREGLVESRY	KDNALVELDHRIHFELREGLVESRY	6.0	1.0	-	-	4244_14:53513647-53513647 C>G_KDNALVELDHRIHFELREGLVESRY	0.0
8:57354324-57354324 A>C	0.0	4326	BREAST	-	-	-	-	PENK	ENST00000314922,p.M104R|ENST00000451791,p.M104R|uc003xsz.2,p.M104R|NM_001135690,p.M104R|NM_006211,p.M104R|uc003xta.3,p.M104R	retained_intron, protein_coding, processed_transcript	uc003xta.3	nonsynonymous SNV	exon4	c.T311G	p.M104R	ESHLLAKRYGGFMKRYGGFMKKMDE	ESHLLAKRYGGFRKRYGGFMKKMDE	3.0	5.0	-	-	4326_8:57354324-57354324 A>C_ESHLLAKRYGGFRKRYGGFMKKMDE	0.0
8:24256411-24256411 G>T	0.0	4234	NSCLC	-	-	-	-	ADAMDEC1	uc011lab.1,p.V184L|ENST00000538205,p.V184L|uc003xdz.2,p.V263L|ENST00000256412,p.V263L|uc010lub.2,p.V184L|ENST00000522298,p.V184L|NM_014479,p.V263L|NM_001145272,p.V184L|NM_001145271,p.V184L	protein_coding, processed_transcript, nonsense_mediated_decay	uc011lab.1	nonsynonymous SNV	exon8	c.G550T	p.V184L	LLNVIYNTIDVQVALVGMEIWSDGD	LLNVIYNTIDVQLALVGMEIWSDGD	8.0	6.0	-	-	4234_8:24256411-24256411 G>T_LLNVIYNTIDVQLALVGMEIWSDGD	0.0
4:128814500-128814501 AC>-	1.0	4281	COLORECTAL	-	-	-	-	PLK4	uc011cgt.2,p.Y709fs|ENST00000270861,p.Y750fs|uc011cgs.2,p.Y718fs|NM_001190799,p.Y718fs|ENST00000507249,p.Y689fs|NM_001190801,p.Y709fs|ENST00000514379,p.Y709fs|NM_014264,p.Y750fs|uc003ifo.3,p.Y750fs|ENST00000515069,p.Y672fs|ENST00000513090,p.Y718fs	retained_intron, protein_coding, processed_transcript	uc011cgt.2	frameshift deletion	exon11	c.2126_2127del	p.Y709fs	DFIQVIEKTGKSYTLKSESEVNSLK	DFIQVIEKTGKSYFKK	7.0	5.0	-	-	4281_4:128814500-128814501 AC>-_DFIQVIEKTGKSYFKK	0.0
17:8006786-8006786 T>A	1.0	4284	COLORECTAL	-	-	-	-	ALOXE3	ENST00000318227,p.N736I|ENST00000448843,p.N604I|NM_021628,p.N604I|uc002gka.3,p.N760I|NM_001165960,p.N736I|uc010vuo.2,p.N736I|ENST00000380149,p.N760I|uc010cnr.3,p.N604I	retained_intron, protein_coding	uc010vuo.2	nonsynonymous SNV	exon15	c.A2207T	p.N736I	NSGQHDFGAWMPNAPSSMRQPPPQT	NSGQHDFGAWMPIAPSSMRQPPPQT	3.0	10.0	-	-	4284_17:8006786-8006786 T>A_NSGQHDFGAWMPIAPSSMRQPPPQT	0.0
14:70634634-70634634 G>A	0.0	4301	MELANOMA	-	-	-	-	SLC8A3	ENST00000357887,p.T169I|NM_183002,p.T169I|NM_182932,p.T169I|ENST00000356921,p.T169I|ENST00000381269,p.T169I|ENST00000528359,p.T169I|uc001xlw.3,p.T169I|NM_033262,p.T169I|uc001xlx.3,p.T169I|ENST00000534137,p.T169I|uc001xlz.3,p.T169I|NM_058240,p.T169I|uc001xly.3,p.T169I|ENST00000494208,p.T169I	protein_coding, processed_transcript, nonsense_mediated_decay	uc001xlz.3	nonsynonymous SNV	exon2	c.C506T	p.T169I	GHGFIAGDLGPSTIVGSAAFNMFII	GHGFIAGDLGPSIIVGSAAFNMFII	3.0	9.0	-	-	4301_14:70634634-70634634 G>A_GHGFIAGDLGPSIIVGSAAFNMFII	0.0
7:1478542-1478542 C>G	1.0	4326	BREAST	-	-	-	-	MICALL2	uc003skj.4,p.G686R|ENST00000405088,p.G474R|ENST00000297508,p.G686R|uc003ski.4,p.G173R|NM_182924,p.G686R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003skj.4	nonsynonymous SNV	exon10	c.G2056C	p.G686R	DVCDNWLRPEPPGQEARVQSWKEEE	DVCDNWLRPEPPRQEARVQSWKEEE	7.0	8.0	-	-	4326_7:1478542-1478542 C>G_DVCDNWLRPEPPRQEARVQSWKEEE	0.0
15:74914482-74914482 C>T	1.0	4259	COLORECTAL	-	-	-	-	CLK3	ENST00000345005,p.R131C|uc002ayj.4,p.R131C|ENST00000352989,p.R131C|ENST00000566126,p.R131C|uc010uln.2,p.R279C|uc002ayg.4,p.R131C|NM_001130028,p.R279C|ENST00000564096,p.R131C|ENST00000395066,p.R279C|ENST00000568139,p.R165C|NM_003992,p.R131C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uln.2	nonsynonymous SNV	exon4	c.C835T	p.R279C	SSASSRSQQSSKRSSRSVEDDKEGH	SSASSRSQQSSKCSSRSVEDDKEGH	10.0	5.0	-	-	4259_15:74914482-74914482 C>T_SSASSRSQQSSKCSSRSVEDDKEGH	0.0
19:18576269-18576269 G>A	1.0	4160	COLORECTAL	-	-	-	1	ELL	ENST00000262809,p.T141M|NM_006532,p.T141M|uc002njh.3,p.T141M|uc010ebq.3,p.T84M	retained_intron, protein_coding, processed_transcript	uc010ebq.3	nonsynonymous SNV	exon5	c.C251T	p.T84M	KARQSMAQAEEETRSRSAIVIKAGG	KARQSMAQAEEEMRSRSAIVIKAGG	7.0	7.0	-	-	4160_19:18576269-18576269 G>A_KARQSMAQAEEEMRSRSAIVIKAGG	0.0
3:97595934-97595934 T>A	1.0	2369	MELANOMA	-	-	-	-	CRYBG3	ENST00000182096,p.S18T|uc021xbn.2,p.S1966T|NM_153605,p.S1966T	protein_coding, processed_transcript	uc021xbn.2	nonsynonymous SNV	exon4	c.T5896A	p.S1966T	PGDTTVRLDKRMSLTAIYDKRRETD	PGDTTVRLDKRMTLTAIYDKRRETD	7.0	6.0	-	-	2369_3:97595934-97595934 T>A_PGDTTVRLDKRMTLTAIYDKRRETD	0.0
1:156776977-156776977 G>A	0.0	2591	MELANOMA	-	-	-	-	SH2D2A	NM_001161442,p.P370L|uc009wsh.2,p.P398L|uc001fqd.2,p.P388L|NM_001161441,p.P398L|ENST00000368199,p.P388L|uc010phs.1,p.P388L|ENST00000392306,p.P398L|ENST00000368198,p.P370L|uc001fqc.1,p.P360L|NM_003975,p.P388L|NM_001161444,p.P388L|NM_001161443,p.P360L|uc001fqe.2,p.P370L	protein_coding, processed_transcript	uc010phs.1	nonsynonymous SNV	exon8	c.C1163T	p.P388L	QDRGQAWLPLGPPQ	QDRGQAWLPLGPLQ	3.0	2.0	-	-	2591_1:156776977-156776977 G>A_QDRGQAWLPLGPLQ	0.0
2:109746315-109746315 G>A	0.0	4235	COLORECTAL	-	-	-	-	SH3RF3	uc021vlv.1,p.S6L	protein_coding	uc021vlv.1	nonsynonymous SNV	exon1	c.C17T	p.S6L	MLAGSSSTPQPTRMRHSG	MLAGSLSTPQPTRMRHSG	4.0	6.0	-	-	4235_2:109746315-109746315 G>A_MLAGSLSTPQPTRMRHSG	0.0
2:179430488-179430488 C>T	0.0	3775	CERVICAL	-	-	-	-	TTN	uc021vtb.2,p.D17726N|NM_003319,p.D17726N|NM_133432,p.D17851N|uc021vta.2,p.D17851N|ENST00000460472,p.D17726N|ENST00000342992,p.D24223N|ENST00000342175,p.D17918N|uc031rqd.1,p.D25150N|uc031rqc.1,p.D26791N|NM_133437,p.D17918N|uc021vsz.2,p.D17918N|ENST00000591111,p.D25150N|ENST00000589042,p.D26791N|NM_001267550,p.D26791N|ENST00000359218,p.D17851N|uc021vsy.2,p.D24223N|NM_133378,p.D24223N|NM_001256850,p.D25150N	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon276	c.G75448A	p.D25150N	EPPSPPGKVTLTDVSQTSASLMWEK	EPPSPPGKVTLTNVSQTSASLMWEK	2.0	5.0	-	-	3775_2:179430488-179430488 C>T_EPPSPPGKVTLTNVSQTSASLMWEK	0.0
22:29130460-29130460 C>T	1.0	4301	MELANOMA	-	-	-	1	CHEK2	ENST00000382578,p.E84K|ENST00000433728,p.E84K|ENST00000382566,p.E84K|ENST00000402731,p.E84K|uc003adv.1,p.E84K|ENST00000433028,p.E84K|ENST00000405598,p.E84K|ENST00000404276,p.E84K|uc010gvh.1,p.E84K|NM_145862,p.E84K|NM_007194,p.E84K|ENST00000382565,p.E84K|uc003adu.1,p.E84K|ENST00000416671,p.E84K|uc003adt.1,p.E84K|ENST00000439200,p.E84K|NM_001005735,p.E84K|ENST00000398017,p.E94K|uc010gvi.1,p.E84K|ENST00000447421,p.E84K|ENST00000328354,p.E84K|ENST00000382580,p.E84K|ENST00000417588,p.E84K|ENST00000448511,p.E84K|ENST00000403642,p.E84K|ENST00000348295,p.E84K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010gvi.1	nonsynonymous SNV	exon1	c.G250A	p.E84K	YSIPEDQEPEDQEPEEPTPAPWARL	YSIPEDQEPEDQKPEEPTPAPWARL	8.0	2.0	-	-	4301_22:29130460-29130460 C>T_YSIPEDQEPEDQKPEEPTPAPWARL	0.0
11:122955333-122955333 C>A	1.0	3466	MELANOMA	-	-	-	-	CLMP	ENST00000448775,p.G92V|NM_024769,p.G92V|uc001pyt.3,p.G92V	retained_intron, protein_coding, processed_transcript	uc001pyt.3	nonsynonymous SNV	exon3	c.G275T	p.G92V	KGRVAFASNFLAGDASLQIEPLKPS	KGRVAFASNFLAVDASLQIEPLKPS	6.0	4.0	-	-	3466_11:122955333-122955333 C>A_KGRVAFASNFLAVDASLQIEPLKPS	0.0
15:52252196-52252196 G>A	1.0	4000	MELANOMA	-	-	-	-	LEO1	ENST00000315141,p.P354S|ENST00000299601,p.P354S|uc002abo.3,p.P354S|NM_138792,p.P354S|uc010bfd.3,p.P354S|NM_001286430,p.P354S	retained_intron, protein_coding	uc010bfd.3	nonsynonymous SNV	exon5	c.C1060T	p.P354S	GLPQDQQEEEPIPETRIEVEIPKVN	GLPQDQQEEEPISETRIEVEIPKVN	8.0	5.0	-	-	4000_15:52252196-52252196 G>A_GLPQDQQEEEPISETRIEVEIPKVN	0.0
7:141952072-141952072 G>A	0.0	3903	MELANOMA	-	-	-	-	PRSS58	uc003vxb.3,p.P232L|uc003vxc.4,p.P232L|ENST00000552471,p.P232L|ENST00000547058,p.P232L|NM_001001317,p.P232L	protein_coding	uc003vxc.4	nonsynonymous SNV	exon6	c.C695T	p.P232L	DVGIYAKIFYYIPWIENVIQNN	DVGIYAKIFYYILWIENVIQNN	1.0	9.0	-	-	3903_7:141952072-141952072 G>A_DVGIYAKIFYYILWIENVIQNN	0.0
11:68665406-68665406 C>G	1.0	4186	BREAST	-	-	-	-	MRPL21	ENST00000541279,p.R74T|uc001ooi.3,p.R74T|uc010rqe.1,p.R74T|ENST00000362034,p.R74T|NM_181514,p.R74T	retained_intron, protein_coding, nonsense_mediated_decay	uc010rqe.1	nonsynonymous SNV	exon3	c.G221C	p.R74T	PEVVLPDPVEETRHHAEVVKKVNEM	PEVVLPDPVEETTHHAEVVKKVNEM	10.0	4.0	-	-	4186_11:68665406-68665406 C>G_PEVVLPDPVEETTHHAEVVKKVNEM	0.0
X:37953569-37953569 A>G	0.0	4245	COLORECTAL	-	-	-	-	SYTL5	NM_001163335,p.M285V|uc004ddv.3,p.M285V|ENST00000456733,p.M285V|ENST00000357972,p.M285V|uc004ddu.3,p.M285V|uc004ddx.3,p.M285V|NM_001163334,p.M285V|ENST00000297875,p.M285V|NM_138780,p.M285V	protein_coding	uc004ddx.3	nonsynonymous SNV	exon7	c.A853G	p.M285V	SVISREYGFENSMDLAAIEGTSQEL	SVISREYGFENSVDLAAIEGTSQEL	5.0	9.0	-	-	4245_X:37953569-37953569 A>G_SVISREYGFENSVDLAAIEGTSQEL	0.0
19:20045509-20045509 C>T	1.0	3713	MELANOMA	-	-	-	-	ZNF93	ENST00000343769,p.S582L|uc002non.3,p.S582L|NM_031218,p.S582L	protein_coding, processed_transcript, nonsense_mediated_decay	uc002non.3	nonsynonymous SNV	exon4	c.C1745T	p.S582L	CGKAFNHSATLSSHKKIHSGEKPYE	CGKAFNHSATLSLHKKIHSGEKPYE	3.0	8.0	-	-	3713_19:20045509-20045509 C>T_CGKAFNHSATLSLHKKIHSGEKPYE	0.0
4:91549285-91549285 G>A	0.0	2556	MELANOMA	-	-	-	-	CCSER1	NM_207491,p.E612K|ENST00000432775,p.E612K|uc003hsv.4,p.E612K|NM_001145065,p.E612K|ENST00000333691,p.E612K|ENST00000509176,p.E612K|uc003hsw.3,p.E612K|ENST00000505073,p.E612K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003hsw.3	nonsynonymous SNV	exon6	c.G1834A	p.E612K	SPSADWPLQGVEENGGIDSLPFRLM	SPSADWPLQGVEKNGGIDSLPFRLM	4.0	4.0	-	-	2556_4:91549285-91549285 G>A_SPSADWPLQGVEKNGGIDSLPFRLM	0.0
7:45141594-45141594 G>A	1.0	2369	MELANOMA	-	-	-	-	TBRG4	ENST00000361278,p.P356L|uc003tmu.3,p.P291L|ENST00000395655,p.P356L|NM_001261834,p.P477L|uc003tmw.4,p.P356L|NM_199122,p.P356L|uc003tmv.4,p.P466L|uc003tmx.4,p.P356L|ENST00000494076,p.P466L|uc011kcd.3,p.P477L|NM_004749,p.P466L|ENST00000258770,p.P466L|NM_030900,p.P356L	retained_intron, protein_coding, processed_transcript	uc011kcd.3	nonsynonymous SNV	exon8	c.C1430T	p.P477L	LLHINATALLEYPEYSGPLLPASAV	LLHINATALLEYLEYSGPLLPASAV	10.0	7.0	-	-	2369_7:45141594-45141594 G>A_LLHINATALLEYLEYSGPLLPASAV	0.0
16:10631889-10631889 G>A	1.0	4155	MELANOMA	-	-	-	-	EMP2	ENST00000359543,p.S71F|ENST00000536829,p.S71F|uc002czx.3,p.S71F|NM_001424,p.S71F	retained_intron, protein_coding, processed_transcript	uc002czx.3	nonsynonymous SNV	exon4	c.C212T	p.S71F	STLQAVQATMILSTILCCIAFFIFV	STLQAVQATMILFTILCCIAFFIFV	9.0	2.0	-	-	4155_16:10631889-10631889 G>A_STLQAVQATMILFTILCCIAFFIFV	0.0
8:118183312-118183312 T>G	0.0	4235	COLORECTAL	-	-	-	-	SLC30A8	ENST00000519688,p.L241R|ENST00000427715,p.L241R|ENST00000456015,p.L290R|NM_001172814,p.L241R|NM_173851,p.L290R|uc011lia.2,p.L241R|NM_001172813,p.L241R|uc003yog.3,p.L241R|ENST00000521243,p.L241R|uc022bab.1,p.L241R|NM_001172815,p.L241R|NM_001172811,p.L241R|uc003yoh.3,p.L290R|uc010mcz.3,p.L241R	retained_intron, protein_coding, processed_transcript	uc022bab.1	nonsynonymous SNV	exon8	c.T722G	p.L241R	VPKSLNYSGVKELILAVDGVLSVHS	VPKSLNYSGVKERILAVDGVLSVHS	1.0	4.0	-	-	4235_8:118183312-118183312 T>G_VPKSLNYSGVKERILAVDGVLSVHS	0.0
15:79298652-79298652 G>A	0.0	4259	COLORECTAL	-	-	-	-	RASGRF1	NM_001145648,p.R651C|ENST00000558480,p.R651C|uc002ber.4,p.R651C|uc002bep.3,p.R651C|uc010unh.1,p.R59C|ENST00000419573,p.R664C|uc002beq.3,p.R664C|uc010blm.1,p.R573C|NM_002891,p.R664C	retained_intron, protein_coding, processed_transcript, TEC	uc010unh.1	nonsynonymous SNV	exon3	c.C175T	p.R59C	SVERLLERLTDLRFLSIDFLNTFLH	SVERLLERLTDLCFLSIDFLNTFLH	5.0	9.0	-	-	4259_15:79298652-79298652 G>A_SVERLLERLTDLCFLSIDFLNTFLH	0.0
X:134427782-134427782 C>A	0.0	4245	COLORECTAL	-	-	-	-	ZNF75D	ENST00000370766,p.E95D|NM_007131,p.E95D|ENST00000370764,p.E95D|uc022ceq.1,p.E95D|NM_001185063,p.E95D|uc004eyo.3,p.E95D	protein_coding, processed_transcript	uc022ceq.1	nonsynonymous SNV	exon2	c.G285T	p.E95D	HSKEQILEMLVLEQFLSILPKETQN	HSKEQILEMLVLDQFLSILPKETQN	8.0	2.0	-	-	4245_X:134427782-134427782 C>A_HSKEQILEMLVLDQFLSILPKETQN	0.0
20:1352812-1352812 T>C	1.0	3919	MELANOMA	-	-	-	-	FKBP1A	uc002wfa.3,p.I91V|ENST00000381715,p.I86V|ENST00000381724,p.I86V|ENST00000439640,p.I75V|NM_054014,p.I91V|uc010gae.2,p.I75V|ENST00000381719,p.I91V|ENST00000400137,p.I91V|uc002wey.3,p.I91V|NM_000801,p.I91V	protein_coding, processed_transcript	uc010gae.2	nonsynonymous SNV	exon3	c.A223G	p.I75V	PDYAYGATGHPGIIPPHATLVFDVE	PDYAYGATGHPGVIPPHATLVFDVE	10.0	2.0	-	-	3919_20:1352812-1352812 T>C_PDYAYGATGHPGVIPPHATLVFDVE	0.0
22:25566875-25566875 C>T	1.0	4095	COLORECTAL	-	-	-	-	KIAA1671	uc003abl.3,p.T47M|ENST00000406486,p.T1540M|NM_001145206,p.T1540M|ENST00000401395,p.T47M|uc003abn.3,p.T1540M|ENST00000358431,p.T1540M	retained_intron, protein_coding	uc003abn.3	nonsynonymous SNV	exon5	c.C4619T	p.T1540M	DTLVHEAGSQYGTWTEQCQSGESLA	DTLVHEAGSQYGMWTEQCQSGESLA	7.0	7.0	-	-	4095_22:25566875-25566875 C>T_DTLVHEAGSQYGMWTEQCQSGESLA	0.0
11:408731-408731 C>T	0.0	3919	MELANOMA	-	-	-	-	SIGIRR	NM_001135053,p.G57E|uc001lpf.2,p.G57E|ENST00000530494,p.G57E|uc001lpd.2,p.G57E|ENST00000397632,p.G57E|ENST00000382520,p.G57E|NM_021805,p.G57E|ENST00000332725,p.G57E|uc001lpe.1,p.G57E|ENST00000531205,p.G57E|uc001lpg.3,p.G57E|NM_001135054,p.G57E|ENST00000431843,p.G57E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001lpg.3	nonsynonymous SNV	exon2	c.G170A	p.G57E	PSVQWLKDGLPLGIGGHYSLHEYSW	PSVQWLKDGLPLEIGGHYSLHEYSW	6.0	10.0	-	-	3919_11:408731-408731 C>T_PSVQWLKDGLPLEIGGHYSLHEYSW	0.0
17:43045127-43045127 C>T	0.0	4298	COLORECTAL	-	-	-	-	C1QL1	NM_006688,p.G97E|uc002ihv.3,p.G97E|ENST00000253407,p.G97E	protein_coding	uc002ihv.3	nonsynonymous SNV	exon1	c.G290A	p.G97E	GDPGPPGPVGPPGEKGEPGKPGPPG	GDPGPPGPVGPPEEKGEPGKPGPPG	4.0	4.0	-	-	4298_17:43045127-43045127 C>T_GDPGPPGPVGPPEEKGEPGKPGPPG	0.0
2:108487231-108487231 A>C	0.0	4320	COLORECTAL	-	-	-	-	RGPD4	NM_182588,p.K924T|ENST00000408999,p.K924T|uc010ywk.2,p.K924T|ENST00000354986,p.K924T|uc002tdu.3,p.K111T	protein_coding	uc010ywk.2	nonsynonymous SNV	exon20	c.A2771C	p.K924T	EGFSIPVSADGFKFGISEPGNQEKE	EGFSIPVSADGFTFGISEPGNQEKE	7.0	1.0	-	-	4320_2:108487231-108487231 A>C_EGFSIPVSADGFTFGISEPGNQEKE	0.0
3:50378858-50378858 C>A	0.0	4298	COLORECTAL	-	-	-	-	ZMYND10	uc010hll.1,p.G431C|NM_015896,p.G436C|ENST00000231749,p.G436C|ENST00000360165,p.G431C|uc003dag.1,p.G436C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010hll.1	nonsynonymous SNV	exon11	c.G1291T	p.G431C	EKHGKTCVLAAQGDRAK	EKHGKTCVLAAQCDRAK	3.0	7.0	-	-	4298_3:50378858-50378858 C>A_EKHGKTCVLAAQCDRAK	0.0
19:54313706-54313706 C>T	0.0	4335	COLORECTAL	-	-	-	-	NLRP12	uc010eqx.4,p.V403I|uc002qcj.5,p.V403I|ENST00000345770,p.V403I|ENST00000391773,p.V403I|NM_144687,p.V403I|NM_001277126,p.V403I|uc002qch.5,p.V403I|ENST00000391772,p.V403I|ENST00000354278,p.V403I|NM_001277129,p.V403I|uc002qci.5,p.V403I|ENST00000324134,p.V403I|ENST00000535162,p.V403I|ENST00000351894,p.V403I|ENST00000391775,p.V403I	retained_intron, protein_coding	uc010eqx.4	nonsynonymous SNV	exon3	c.G1207A	p.V403I	VRDNEPLFTMCFVPLVCWVVCTCLQ	VRDNEPLFTMCFIPLVCWVVCTCLQ	6.0	9.0	-	-	4335_19:54313706-54313706 C>T_VRDNEPLFTMCFIPLVCWVVCTCLQ	0.0
9:86928366-86928366 C>T	0.0	2591	MELANOMA	-	-	-	-	SLC28A3	NM_022127,p.E22K|uc004anu.2,p.E22K|NM_001199633,p.E22K|ENST00000376238,p.E22K|uc010mpz.3,p.E22K	protein_coding, processed_transcript	uc010mpz.3	nonsynonymous SNV	exon2	c.G64A	p.E22K	RAEGYSNVGFQNEENFLENENTSGN	RAEGYSNVGFQNKENFLENENTSGN	2.0	3.0	-	-	2591_9:86928366-86928366 C>T_RAEGYSNVGFQNKENFLENENTSGN	0.0
12:40717004-40717004 C>T	1.0	3998	MELANOMA	-	-	-	-	LRRK2	uc001rmg.4,p.P1851L|uc009zjw.3,p.P689L|ENST00000298910,p.P1851L|uc001rmi.3,p.P684L|NM_198578,p.P1851L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zjw.3	nonsynonymous SNV	exon17	c.C2066T	p.P689L	LLVNPDQPRLTIPISQIAPDLILAD	LLVNPDQPRLTILISQIAPDLILAD	7.0	9.0	-	-	3998_12:40717004-40717004 C>T_LLVNPDQPRLTILISQIAPDLILAD	0.0
21:40193564-40193564 C>T	1.0	3879	MELANOMA	-	-	-	-	ETS2	NM_005239,p.S377F|ENST00000360938,p.S377F|ENST00000360214,p.S377F|NM_001256295,p.S517F|uc002yxf.3,p.S517F|uc002yxg.4,p.S377F	protein_coding	uc002yxg.4	nonsynonymous SNV	exon9	c.C1130T	p.S377F	LWQFLLELLSDKSCQSFISWTGDGW	LWQFLLELLSDKFCQSFISWTGDGW	7.0	6.0	-	-	3879_21:40193564-40193564 C>T_LWQFLLELLSDKFCQSFISWTGDGW	0.0
1:67438613-67438613 G>A	1.0	3713	MELANOMA	-	-	-	-	MIER1	uc001ddh.2,p.R231K|NM_001146113,p.R231K|NM_020948,p.R311K|ENST00000371016,p.R311K|uc001ddj.1,p.R294K|uc001ddf.2,p.R311K|uc001ddg.2,p.R267K|uc010opg.1,p.R311K|uc001ddc.2,p.R347K|uc010opf.1,p.R311K|ENST00000371018,p.R311K|NM_001077700,p.R347K|uc001dde.2,p.R347K|NM_001146110,p.R311K|NM_001146111,p.R311K|ENST00000355977,p.R231K|ENST00000371014,p.R347K|NM_001077701,p.R294K|ENST00000401042,p.R294K|NM_001146112,p.R267K|NM_001077703,p.R347K|uc001ddi.2,p.R294K|NM_001077702,p.R311K|ENST00000355356,p.R294K|uc009way.2,p.R311K|NM_001077704,p.R294K|ENST00000401041,p.R347K|ENST00000357692,p.R311K	protein_coding, processed_transcript	uc010opg.1	nonsynonymous SNV	exon12	c.G932A	p.R311K	REELSVWTEEECRNFEQGLKAYGKD	REELSVWTEEECKNFEQGLKAYGKD	7.0	4.0	-	-	3713_1:67438613-67438613 G>A_REELSVWTEEECKNFEQGLKAYGKD	0.0
11:62598584-62598584 ->G	1.0	4284	COLORECTAL	-	-	ID=COSM112032;OCCURENCE=1(ovary),4(large_intestine)	-	STX5	uc001nvh.3,p.P44fs|NM_001244666,p.P44fs|NM_003164,p.P44fs|uc010rmj.2,p.P44fs	-	uc010rmj.2	frameshift insertion	exon2	c.131dupC	p.P44fs	GSSSSDIAPLPPPVTLVPPPPDTMS	GSSSSDIAPLPPPSDPRPSPSRHHVLPGSDPGVSVCLQVAADPSEWNPDK	9.0	7.0	-	-	4284_11:62598584-62598584 ->G_GSSSSDIAPLPPPSDPRPSPSRHHVLPGSDPGVSVCLQVAADPSEWNPDK	0.0
5:112162917-112162917 ->T	1.0	4317	COLORECTAL	-	-	-	1	APC	ENST00000512211,p.N507fs|ENST00000508376,p.N507fs|uc003kpy.4,p.N507fs|ENST00000507379,p.N489fs|NM_001127511,p.N489fs|uc003kpz.4,p.N507fs|NM_000038,p.N507fs|NM_001127510,p.N507fs|ENST00000504915,p.N70fs|uc011cvt.2,p.N489fs|ENST00000457016,p.N507fs|uc010jbz.3,p.N224fs|ENST00000257430,p.N507fs	 processed_transcript,retained_intron, protein_coding, nonsense_mediated_decay	uc011cvt.2	frameshift insertion	exon10	c.1468dupT	p.N489fs	ITLRRYAGMALTNLTFGDVANKATL	ITLRRYAGMALTNFDFWRCSQQGYAMLYERLHESTCGPTKI	8.0	10.0	-	-	4317_5:112162917-112162917 ->T_ITLRRYAGMALTNFDFWRCSQQGYAMLYERLHESTCGPTKI	0.0
12:102158720-102158720 G>A	1.0	3713	MELANOMA	-	-	-	-	GNPTAB	uc001tit.3,p.L659F|NM_024312,p.L659F|ENST00000299314,p.L659F	retained_intron, protein_coding, nonsense_mediated_decay	uc001tit.3	nonsynonymous SNV	exon13	c.C1975T	p.L659F	KGYENLVSPITLLPEAEILFEDIPK	KGYENLVSPITLFPEAEILFEDIPK	9.0	6.0	-	-	3713_12:102158720-102158720 G>A_KGYENLVSPITLFPEAEILFEDIPK	0.0
7:21640506-21640506 A>C	0.0	4238	COLORECTAL	-	-	-	-	DNAH11	uc031swp.1,p.E1071D|NM_001277115,p.E1071D|ENST00000409508,p.E1071D|ENST00000328843,p.E1071D	retained_intron, protein_coding, processed_transcript	uc031swp.1	nonsynonymous SNV	exon16	c.A3213C	p.E1071D	VSSDEMDAHANEEIPEQPPTLEQFK	VSSDEMDAHANEDIPEQPPTLEQFK	2.0	6.0	-	-	4238_7:21640506-21640506 A>C_VSSDEMDAHANEDIPEQPPTLEQFK	0.0
22:38150888-38150888 C>T	1.0	4000	MELANOMA	-	-	-	-	TRIOBP	NM_138632,p.P82L|NM_007032,p.P82L|uc003atw.3,p.P82L|NM_001039141,p.P1795L|uc003atv.3,p.P82L|ENST00000418339,p.P41L|ENST00000403663,p.P82L|ENST00000407319,p.P82L|uc003atr.3,p.P1795L|uc003atu.3,p.P1623L|ENST00000406386,p.P1795L	retained_intron, protein_coding, nonsense_mediated_decay	uc003atw.3	nonsynonymous SNV	exon3	c.C245T	p.P82L	GWMSILDEPGEPPSPSLTTTSTSQW	GWMSILDEPGEPLSPSLTTTSTSQW	9.0	8.0	-	-	4000_22:38150888-38150888 C>T_GWMSILDEPGEPLSPSLTTTSTSQW	0.0
9:75773675-75773675 C>T	1.0	3713	MELANOMA	-	-	-	-	ANXA1	ENST00000257497,p.P44L|ENST00000376911,p.P44L|uc004ajf.1,p.P44L|ENST00000415424,p.P44L|ENST00000456643,p.P55L|NM_000700,p.P44L|uc004ajg.1,p.P44L	protein_coding, processed_transcript	uc004ajg.1	nonsynonymous SNV	exon2	c.C131T	p.P44L	PGSAVSPYPTFNPSSDVAALHKAIM	PGSAVSPYPTFNLSSDVAALHKAIM	10.0	3.0	-	-	3713_9:75773675-75773675 C>T_PGSAVSPYPTFNLSSDVAALHKAIM	0.0
17:48431776-48431776 G>A	1.0	3775	CERVICAL	-	-	-	-	XYLT2	uc002iqo.3,p.M212I|ENST00000507602,p.M212I|NM_022167,p.M212I|ENST00000017003,p.M212I|ENST00000376550,p.M212I	retained_intron, protein_coding, nonsense_mediated_decay	uc002iqo.3	nonsynonymous SNV	exon3	c.G636A	p.M212I	KAVPRHCQLTGKMSPGIQWDESQAQ	KAVPRHCQLTGKISPGIQWDESQAQ	6.0	10.0	-	-	3775_17:48431776-48431776 G>A_KAVPRHCQLTGKISPGIQWDESQAQ	0.0
12:1749063-1749063 G>A	0.0	3713	MELANOMA	-	-	-	-	WNT5B	NM_030775,p.R181Q|NM_032642,p.R181Q|ENST00000543071,p.R181Q|uc009zdq.3,p.R181Q|uc001qjk.3,p.R181Q|uc001qjj.3,p.R181Q|ENST00000397196,p.R181Q|ENST00000310594,p.R181Q|uc001qjl.3,p.R181Q|ENST00000537031,p.R181Q	protein_coding, processed_transcript	uc009zdq.3	nonsynonymous SNV	exon4	c.G542A	p.R181Q	YRFAKEFVDAREREKNFAKGSEEQG	YRFAKEFVDAREQEKNFAKGSEEQG	2.0	7.0	-	-	3713_12:1749063-1749063 G>A_YRFAKEFVDAREQEKNFAKGSEEQG	0.0
13:33327484-33327484 A>C	0.0	4345	COLORECTAL	-	-	-	-	PDS5B	uc010abf.3,p.Q917H|ENST00000450460,p.Q917H|ENST00000315596,p.Q917H|NM_015032,p.Q917H	retained_intron, protein_coding, nonsense_mediated_decay	uc010abf.3	nonsynonymous SNV	exon25	c.A2751C	p.Q917H	QLCALAINDECYQVRQVFAQKLHKG	QLCALAINDECYHVRQVFAQKLHKG	9.0	2.0	-	-	4345_13:33327484-33327484 A>C_QLCALAINDECYHVRQVFAQKLHKG	0.0
9:88247668-88247668 C>T	0.0	4186	BREAST	-	-	-	-	AGTPBP1	NM_015239,p.E602K|uc011ltd.2,p.E642K|ENST00000432218,p.E480K|uc011lte.2,p.E654K|ENST00000357081,p.E642K|ENST00000376083,p.E602K|NM_001286715,p.E694K|ENST00000376109,p.E654K|uc004aod.4,p.E268K|uc011ltc.2,p.E540K|uc010mqc.3,p.E602K|NM_001286717,p.E654K	protein_coding, processed_transcript	uc011lte.2	nonsynonymous SNV	exon13	c.G1960A	p.E654K	YIEIVKNTKSVPEYSEVAYPDYFGH	YIEIVKNTKSVPKYSEVAYPDYFGH	5.0	5.0	-	-	4186_9:88247668-88247668 C>T_YIEIVKNTKSVPKYSEVAYPDYFGH	0.0
11:45241212-45241212 C>T	0.0	3998	MELANOMA	-	-	-	-	PRDM11	NM_001256696,p.R216W|ENST00000424263,p.R216W|uc031pzz.1,p.R247W|ENST00000263765,p.R250W|uc031qaa.1,p.R216W|ENST00000530656,p.R250W|NM_001256695,p.R216W|uc031qab.1,p.R216W	protein_coding, processed_transcript	uc031qab.1	nonsynonymous SNV	exon6	c.C646T	p.R216W	SERIYFRACRDIRPGEWLRVWYSED	SERIYFRACRDIWPGEWLRVWYSED	5.0	8.0	-	-	3998_11:45241212-45241212 C>T_SERIYFRACRDIWPGEWLRVWYSED	0.0
1:76877984-76877984 G>A	0.0	4346	COLORECTAL	0.0005	-	ID=COSM912201;OCCURENCE=1(endometrium)	-	ST6GALNAC3	ENST00000328299,p.V169I|uc010orh.1,p.V104I|uc001dhh.2,p.V169I|NM_001160011,p.V169I|uc001dhg.4,p.V169I|NM_152996,p.V169I	protein_coding, processed_transcript	uc010orh.1	nonsynonymous SNV	exon2	c.G310A	p.V104I	PFRNMRKDGNGIVYNMLKKTVGIYP	PFRNMRKDGNGIIYNMLKKTVGIYP	3.0	10.0	-	-	4346_1:76877984-76877984 G>A_PFRNMRKDGNGIIYNMLKKTVGIYP	0.0
2:21250760-21250760 T>A	0.0	4213	COLORECTAL	-	-	-	-	APOB	uc002red.3,p.K669N|NM_000384,p.K669N|ENST00000233242,p.K669N|ENST00000399256,p.K669N	protein_coding	uc002red.3	nonsynonymous SNV	exon14	c.A2007T	p.K669N	GNLIFDPNNYLPKESMLKTTLTAFG	GNLIFDPNNYLPNESMLKTTLTAFG	2.0	7.0	-	-	4213_2:21250760-21250760 T>A_GNLIFDPNNYLPNESMLKTTLTAFG	0.0
12:109717570-109717570 G>A	0.0	4326	BREAST	-	-	-	-	FOXN4	uc009zvg.3,p.A284V|uc001tof.4,p.A307V|ENST00000355216,p.A307V|NM_213596,p.A487V|uc001toe.4,p.A487V|ENST00000299162,p.A487V	protein_coding, processed_transcript, nonsense_mediated_decay	uc009zvg.3	nonsynonymous SNV	exon7	c.C851T	p.A284V	SFPDLQVTGLYTAYSTPDSVAASGT	SFPDLQVTGLYTVYSTPDSVAASGT	3.0	4.0	-	-	4326_12:109717570-109717570 G>A_SFPDLQVTGLYTVYSTPDSVAASGT	0.0
12:67691552-67691552 C>T	1.0	3466	MELANOMA	-	-	-	-	CAND1	ENST00000540319,p.P140L|ENST00000545606,p.P258L|uc001stn.2,p.P258L|NM_018448,p.P258L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001stn.2	nonsynonymous SNV	exon6	c.C773T	p.P258L	GHRIGEYLEKIIPLVVKFCNVDDDE	GHRIGEYLEKIILLVVKFCNVDDDE	10.0	9.0	-	-	3466_12:67691552-67691552 C>T_GHRIGEYLEKIILLVVKFCNVDDDE	0.0
19:2115578-2115578 G>A	1.0	3713	MELANOMA	-	-	-	-	AP3D1	ENST00000345016,p.P703L|uc002lva.4,p.P703L|ENST00000350812,p.P534L|ENST00000355272,p.P703L|uc002luz.4,p.P703L|NM_001261826,p.P703L|NM_003938,p.P703L|uc031riw.1,p.P431L|ENST00000356926,p.P612L	retained_intron, protein_coding, processed_transcript	uc031riw.1	nonsynonymous SNV	exon12	c.C1292T	p.P431L	KRYQDTPGVEHIPVVQIDLSVPLKV	KRYQDTPGVEHILVVQIDLSVPLKV	8.0	4.0	-	-	3713_19:2115578-2115578 G>A_KRYQDTPGVEHILVVQIDLSVPLKV	0.0
7:100357385-100357385 C>G	0.0	4326	BREAST	-	-	-	-	ZAN	uc003uwj.3,p.Q1205E|ENST00000538115,p.Q1205E|uc003uwk.3,p.Q1205E|ENST00000546292,p.Q1205E|ENST00000542585,p.Q1205E	protein_coding, polymorphic_pseudogene	uc003uwk.3	nonsynonymous SNV	exon18	c.C3613G	p.Q1205E	FFRVTAKNEEQGQEGVSCLSKVYVT	FFRVTAKNEEQGEEGVSCLSKVYVT	2.0	7.0	-	-	4326_7:100357385-100357385 C>G_FFRVTAKNEEQGEEGVSCLSKVYVT	0.0
12:124377780-124377780 G>A	0.0	3903	MELANOMA	-	-	-	-	DNAH10	uc001uft.4,p.G2881E|ENST00000409039,p.G2881E|NM_207437,p.G2881E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001uft.4	nonsynonymous SNV	exon52	c.G8642A	p.G2881E	GFLELINNMLTSGIVPALFSEEEKE	GFLELINNMLTSEIVPALFSEEEKE	4.0	2.0	-	-	3903_12:124377780-124377780 G>A_GFLELINNMLTSEIVPALFSEEEKE	0.0
21:37610932-37610932 G>A	1.0	4234	NSCLC	-	-	-	-	DOPEY2	uc011aeb.2,p.V886M	retained_intron, protein_coding, processed_transcript	uc011aeb.2	nonsynonymous SNV	exon15	c.G2656A	p.V886M	QGTRLEALFRFSVIWHLTREIQGSR	QGTRLEALFRFSMIWHLTREIQGSR	7.0	7.0	CD8	-	4234_21:37610932-37610932 G>A_QGTRLEALFRFSMIWHLTREIQGSR	2.0
1:71542504-71542504 T>G	1.0	4071	COLORECTAL	-	-	-	-	ZRANB2	ENST00000254821,p.K92T|NM_203350,p.K92T|uc001dft.3,p.K92T|ENST00000370920,p.K92T|NM_005455,p.K92T|uc001dfs.3,p.K92T	protein_coding, processed_transcript	uc001dft.3	nonsynonymous SNV	exon4	c.A275C	p.K92T	ARRSECNMCNTPKYAKLEERTGYGG	ARRSECNMCNTPTYAKLEERTGYGG	9.0	6.0	-	-	4071_1:71542504-71542504 T>G_ARRSECNMCNTPTYAKLEERTGYGG	0.0
X:32841428-32841428 A>C	0.0	4158	COLORECTAL	-	-	-	-	DMD	ENST00000447523,p.I77R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000447523	nonsynonymous SNV	exon3	c.T230G	p.I77R	GNHKLTLGLIWNIILHWQVLGDRWA	GNHKLTLGLIWNRILHWQVLGDRWA	5.0	6.0	-	-	4158_X:32841428-32841428 A>C_GNHKLTLGLIWNRILHWQVLGDRWA	0.0
6:117047682-117047682 C>T	0.0	2224	MELANOMA	-	-	ID=COSM109477;OCCURENCE=1(skin)	-	KPNA5	uc003pxh.3,p.P384S|NM_002269,p.P384S|ENST00000368564,p.P384S|ENST00000356348,p.P384S	protein_coding	uc003pxh.3	nonsynonymous SNV	exon12	c.C1150T	p.P384S	AQIQAVIDANIFPVLIEILQKAEFR	AQIQAVIDANIFSVLIEILQKAEFR	6.0	9.0	CD8	-	2224_6:117047682-117047682 C>T_AQIQAVIDANIFSVLIEILQKAEFR	1.0
6:43305054-43305054 C>A	1.0	4129	NSCLC	-	-	-	-	ZNF318	NM_014345,p.D2228Y|uc003oux.3,p.D2228Y|ENST00000361428,p.D2228Y	protein_coding	uc003oux.3	nonsynonymous SNV	exon10	c.G6682T	p.D2228Y	STTEVAILQVDDDSGDPLNLVKAPV	STTEVAILQVDDYSGDPLNLVKAPV	6.0	9.0	-	-	4129_6:43305054-43305054 C>A_STTEVAILQVDDYSGDPLNLVKAPV	0.0
3:179527365-179527365 C>T	0.0	4275	COLORECTAL	-	-	-	-	PEX5L	ENST00000392649,p.A308T|uc011bqf.2,p.A308T|uc003fkj.2,p.A381T|NM_001256756,p.A224T|NM_001256755,p.A308T|ENST00000485199,p.A381T|uc003fki.2,p.A416T|ENST00000467460,p.A416T|NM_016559,p.A416T|NM_001256752,p.A381T|ENST00000476138,p.A373T|NM_001256754,p.A373T|NM_001256753,p.A357T|uc011bqg.2,p.A392T|ENST00000472994,p.A357T|uc011bqh.2,p.A357T|uc010hxd.2,p.A414T|uc011bqe.2,p.A224T|ENST00000468741,p.A224T|uc011bqd.2,p.A373T|NM_001256750,p.A414T|ENST00000263962,p.A414T|ENST00000464614,p.A308T|ENST00000465751,p.A392T|NM_001256751,p.A392T	retained_intron, protein_coding, processed_transcript	uc011bqh.2	nonsynonymous SNV	exon10	c.G1069A	p.A357T	YTNTGHQQDACDALKNWIKQNPKYK	YTNTGHQQDACDTLKNWIKQNPKYK	1.0	4.0	-	-	4275_3:179527365-179527365 C>T_YTNTGHQQDACDTLKNWIKQNPKYK	0.0
X:68748968-68748968 G>A	0.0	2556	MELANOMA	-	-	-	-	FAM155B	ENST00000252338,p.E332K|NM_015686,p.E332K|uc004dxk.3,p.E332K	protein_coding	uc004dxk.3	nonsynonymous SNV	exon2	c.G994A	p.E332K	QTRCPFILPDNEEMVYGGLPGFICT	QTRCPFILPDNEKMVYGGLPGFICT	2.0	2.0	-	-	2556_X:68748968-68748968 G>A_QTRCPFILPDNEKMVYGGLPGFICT	0.0
2:138434117-138434117 G>C	0.0	4238	COLORECTAL	-	-	-	-	THSD7B	ENST00000409968,p.S1588T|ENST00000272643,p.S1591T|ENST00000413152,p.S1560T	retained_intron, protein_coding, processed_transcript	ENST00000413152	nonsynonymous SNV	exon28	c.G4679C	p.S1560T	SYLVCKKPKPHQSTPPQQKPLTLAY	SYLVCKKPKPHQTTPPQQKPLTLAY	1.0	4.0	-	-	4238_2:138434117-138434117 G>C_SYLVCKKPKPHQTTPPQQKPLTLAY	0.0
5:33891901-33891901 A>C	0.0	4252	COLORECTAL	-	-	-	-	ADAMTS12	uc003jib.1,p.F21V|ENST00000352040,p.F21V|uc010iuq.1,p.F21V|NM_030955,p.F21V|ENST00000504830,p.F21V|uc003jia.1,p.F21V|ENST00000515401,p.F21V	protein_coding, processed_transcript	uc010iuq.1	nonsynonymous SNV	exon1	c.T61G	p.F21V	LANLSVVAQLLNFGALCYGRQPQPG	LANLSVVAQLLNVGALCYGRQPQPG	5.0	7.0	-	-	4252_5:33891901-33891901 A>C_LANLSVVAQLLNVGALCYGRQPQPG	0.0
1:208390435-208390435 G>A	1.0	4278	COLORECTAL	-	-	-	-	PLXNA2	uc001hha.4,p.S332L|NM_025179,p.S278L|ENST00000367033,p.S278L|uc001hgz.3,p.S278L	protein_coding, processed_transcript	uc001hha.4	nonsynonymous SNV	exon1	c.C995T	p.S332L	VAINSAGDLFYTSRIVRLCKDDPKF	VAINSAGDLFYTLRIVRLCKDDPKF	6.0	3.0	-	-	4278_1:208390435-208390435 G>A_VAINSAGDLFYTLRIVRLCKDDPKF	0.0
2:31489200-31489200 C>T	1.0	4284	COLORECTAL	-	-	-	-	EHD3	uc002rnu.3,p.A413V|ENST00000322054,p.A413V|NM_014600,p.A413V	protein_coding	uc002rnu.3	nonsynonymous SNV	exon6	c.C1238T	p.A413V	ESQRPIQMVKGGAFEGTLHGPFGHG	ESQRPIQMVKGGVFEGTLHGPFGHG	5.0	8.0	-	-	4284_2:31489200-31489200 C>T_ESQRPIQMVKGGVFEGTLHGPFGHG	0.0
17:74086418-74086418 G>A	1.0	4284	COLORECTAL	-	-	-	-	EXOC7	ENST00000411744,p.P290L|NM_001145297,p.P349L|uc010wsx.2,p.P290L|ENST00000607838,p.P321L|ENST00000335146,p.P349L|uc010wsw.2,p.P321L|ENST00000405575,p.P321L|NM_001145298,p.P290L|uc002jqs.3,p.P349L|NM_001145299,p.P321L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wsx.2	nonsynonymous SNV	exon7	c.C869T	p.P290L	KHLSEALNDKHGPLAGRDDMLDVET	KHLSEALNDKHGLLAGRDDMLDVET	9.0	10.0	-	-	4284_17:74086418-74086418 G>A_KHLSEALNDKHGLLAGRDDMLDVET	0.0
20:5294762-5294762 C>T	0.0	4213	COLORECTAL	-	-	-	-	PROKR2	ENST00000217270,p.R85H|uc010zqx.2,p.R85H|uc010zqy.2,p.R85H|ENST00000546004,p.R85H|NM_144773,p.R85H|uc010zqw.2,p.R85H	protein_coding	uc010zqy.2	nonsynonymous SNV	exon2	c.G254A	p.R85H	VFIAALTRYKKLRNLTNLLIANLAI	VFIAALTRYKKLHNLTNLLIANLAI	1.0	10.0	-	-	4213_20:5294762-5294762 C>T_VFIAALTRYKKLHNLTNLLIANLAI	0.0
6:31896559-31896559 C>T	1.0	2369	MELANOMA	-	-	-	-	C2	ENST00000477310,p.R103W|uc003nyf.3,p.R103W|uc003nye.4,p.R103W|NM_000063,p.R103W|NM_001282458,p.R74W|ENST00000418949,p.R103W|ENST00000299367,p.R103W|NM_001282459,p.R103W|uc011doq.2,p.R74W|ENST00000413154,p.R103W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011doq.2	nonsynonymous SNV	exon3	c.C220T	p.R74W	APVSFENGIYTPRLGSYPVGGNVSF	APVSFENGIYTPWLGSYPVGGNVSF	8.0	9.0	-	-	2369_6:31896559-31896559 C>T_APVSFENGIYTPWLGSYPVGGNVSF	0.0
11:26582766-26582766 C>T	1.0	3903	MELANOMA	-	-	-	-	MUC15	ENST00000455601,p.R284Q|uc001mqx.3,p.R284Q|uc001mqw.3,p.R311Q|NM_145650,p.R284Q|ENST00000436318,p.R311Q|ENST00000529533,p.R311Q|NM_001135091,p.R311Q	protein_coding	uc001mqx.3	nonsynonymous SNV	exon4	c.G851A	p.R284Q	RRLYDDRNEPVLRLDNAPEPYDVSF	RRLYDDRNEPVLQLDNAPEPYDVSF	9.0	2.0	-	-	3903_11:26582766-26582766 C>T_RRLYDDRNEPVLQLDNAPEPYDVSF	0.0
11:12951870-12951870 A>T	1.0	3466	MELANOMA	-	-	-	-	TEAD1	ENST00000527575,p.L330F|ENST00000361985,p.L388F|ENST00000527636,p.L388F|ENST00000526600,p.L292F|ENST00000361905,p.L373F|NM_021961,p.L388F|uc009ygl.3,p.L209F|uc001mkk.4,p.L292F|ENST00000334310,p.L319F|uc021qdx.1,p.L388F	retained_intron, protein_coding	uc021qdx.1	nonsynonymous SNV	exon12	c.A1164T	p.L388F	YMMNSVLENFTILLVVTNRDTQETL	YMMNSVLENFTIFLVVTNRDTQETL	10.0	6.0	CD8	-	3466_11:12951870-12951870 A>T_YMMNSVLENFTIFLVVTNRDTQETL	1.0
17:7578190-7578190 T>C	1.0	4259	COLORECTAL	-	-	ID=COSM99718,COSM3355993,COSM99719,COSM1644277,COSM99720,COSM10758;OCCURENCE=18(oesophagus),1(bone),27(upper_aerodigestive_tract),20(central_nervous_system),12(stomach),12(haematopoietic_and_lymphoid_tissue),1(peritoneum),27(lung),4(endometrium),44(ovary),7(soft_tissue),17(large_intestine),1(biliary_tract),1(prostate),8(liver),5(pancreas),16(urinary_tract),3(small_intestine),33(breast),1(skin)	1	TP53	NM_001126114,p.Y220C|NM_001276695,p.Y181C|ENST00000413465,p.Y220C|uc010cnf.2,p.Y61C|NM_001276699,p.Y61C|NM_001126112,p.Y220C|NM_001276760,p.Y181C|ENST00000359597,p.Y220C|NM_001126116,p.Y88C|ENST00000514944,p.Y127C|ENST00000269305,p.Y220C|uc002gii.2,p.Y61C|ENST00000509690,p.Y88C|NM_001276698,p.Y61C|uc002gih.3,p.Y220C|NM_001276696,p.Y181C|ENST00000455263,p.Y220C|NM_001126115,p.Y88C|ENST00000420246,p.Y220C|uc002gij.3,p.Y181C|uc031qyq.1,p.Y181C|NM_001126117,p.Y88C|uc010cng.2,p.Y61C|uc002gin.3,p.Y127C|ENST00000445888,p.Y220C|uc002gig.1,p.Y220C|uc002gio.3,p.Y88C|NM_000546,p.Y220C|NM_001126118,p.Y181C|NM_001276761,p.Y181C|NM_001276697,p.Y61C|NM_001126113,p.Y220C	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon5	c.A542G	p.Y181C	DRNTFRHSVVVPYEPPEVGSDCTTI	DRNTFRHSVVVPCEPPEVGSDCTTI	9.0	10.0	CD8	-	4259_17:7578190-7578190 T>C_DRNTFRHSVVVPCEPPEVGSDCTTI	1.0
1:94048148-94048148 G>A	1.0	4196	COLORECTAL	-	-	-	-	BCAR3	ENST00000260502,p.P466S|NM_001261409,p.P466S|NM_003567,p.P466S|ENST00000370247,p.P375S|uc009wdm.1,p.P142S|ENST00000370243,p.P466S|ENST00000539242,p.P142S|ENST00000370244,p.P466S|uc001dpz.4,p.P466S|NM_001261410,p.P375S|NM_001261408,p.P466S|uc001dqa.4,p.P466S|uc001dpx.5,p.P142S|uc001dpy.4,p.P375S|uc001dqb.4,p.P466S	retained_intron, protein_coding, processed_transcript	uc009wdm.1	nonsynonymous SNV	exon3	c.C424T	p.P142S	HTELLTAKQNEAPGPRNSGVNYLIL	HTELLTAKQNEASGPRNSGVNYLIL	7.0	10.0	-	-	4196_1:94048148-94048148 G>A_HTELLTAKQNEASGPRNSGVNYLIL	0.0
8:91657878-91657878 C>T	1.0	4284	COLORECTAL	-	-	-	-	TMEM64	uc011lgf.1,p.G86R|ENST00000458549,p.G86R|NM_001146273,p.G86R|ENST00000418210,p.G86R|uc003yen.2,p.G86R|NM_001008495,p.G86R	protein_coding, processed_transcript	uc011lgf.1	nonsynonymous SNV	exon1	c.G256A	p.G86R	GPPEASELPEPGGALAGGPGSGGGG	GPPEASELPEPGRALAGGPGSGGGG	6.0	5.0	-	-	4284_8:91657878-91657878 C>T_GPPEASELPEPGRALAGGPGSGGGG	0.0
16:67650654-67650654 G>A	0.0	4186	BREAST	-	-	-	1	CTCF	ENST00000264010,p.R320H|NM_006565,p.R320H|uc002etl.3,p.R320H	retained_intron, protein_coding	uc002etl.3	nonsynonymous SNV	exon5	c.G959A	p.R320H	LLRNHLNTHTGTRPHKCPDCDMAFV	LLRNHLNTHTGTHPHKCPDCDMAFV	8.0	10.0	-	-	4186_16:67650654-67650654 G>A_LLRNHLNTHTGTHPHKCPDCDMAFV	0.0
5:140182140-140182140 C>T	1.0	4278	COLORECTAL	-	-	-	-	PCDHA3	ENST00000522353,p.P453L|NM_031497,p.P453L|ENST00000532566,p.P453L|uc011czz.2,p.P453L|NM_018906,p.P453L|uc003lhf.2,p.P453L	protein_coding	uc011czz.2	nonsynonymous SNV	exon1	c.C1358T	p.P453L	VSVEVADVNDNAPAFSQSEYTVFVK	VSVEVADVNDNALAFSQSEYTVFVK	6.0	10.0	-	-	4278_5:140182140-140182140 C>T_VSVEVADVNDNALAFSQSEYTVFVK	0.0
5:38883931-38883931 C>G	0.0	4316	COLORECTAL	-	-	-	-	OSMR	NM_001168355,p.Q141E|uc003jln.2,p.Q141E|ENST00000274276,p.Q141E|uc003jlm.2,p.Q141E|NM_003999,p.Q141E|ENST00000502536,p.Q141E	protein_coding, nonsense_mediated_decay	uc003jln.2	nonsynonymous SNV	exon5	c.C421G	p.Q141E	WSNWSSWEEVSVQDSTGQDILFVFP	WSNWSSWEEVSVEDSTGQDILFVFP	5.0	6.0	-	-	4316_5:38883931-38883931 C>G_WSNWSSWEEVSVEDSTGQDILFVFP	0.0
15:79265673-79265673 C>T	1.0	4245	COLORECTAL	-	-	-	-	RASGRF1	uc002bep.3,p.G1195D|NM_002891,p.G1211D|uc002beq.3,p.G1211D|NM_001145648,p.G1195D|ENST00000394745,p.G427D|NM_153815,p.G427D|ENST00000558480,p.G1195D|uc002beo.3,p.G427D|ENST00000419573,p.G1211D	retained_intron, protein_coding, processed_transcript, TEC	uc002beq.3	nonsynonymous SNV	exon26	c.G3632A	p.G1211D	FIEEGTPNYTEDGLVNFSKMRMISH	FIEEGTPNYTEDDLVNFSKMRMISH	5.0	8.0	-	-	4245_15:79265673-79265673 C>T_FIEEGTPNYTEDDLVNFSKMRMISH	0.0
6:41160541-41160541 G>T	1.0	4259	COLORECTAL	-	-	-	-	TREML2	NM_024807,p.A295E|ENST00000483722,p.A295E|uc010jxm.1,p.A295E	protein_coding	uc010jxm.1	nonsynonymous SNV	exon4	c.C884A	p.A295E	IMVYGFWKKRHMASYSMCSDPSTRD	IMVYGFWKKRHMESYSMCSDPSTRD	5.0	9.0	-	-	4259_6:41160541-41160541 G>T_IMVYGFWKKRHMESYSMCSDPSTRD	0.0
X:135080654-135080654 G>A	1.0	3678	MELANOMA	-	-	-	-	SLC9A6	ENST00000370701,p.R154Q|uc011mvx.2,p.R154Q|NM_001177651,p.R154Q|ENST00000370695,p.R206Q|NM_006359,p.R174Q|ENST00000370698,p.R174Q|uc004ezj.3,p.R174Q|uc004ezk.3,p.R206Q|NM_001042537,p.R206Q	protein_coding	uc011mvx.2	nonsynonymous SNV	exon5	c.G461A	p.R154Q	YAGYSLKRRHFFRNLGSILAYAFLG	YAGYSLKRRHFFQNLGSILAYAFLG	7.0	9.0	-	-	3678_X:135080654-135080654 G>A_YAGYSLKRRHFFQNLGSILAYAFLG	0.0
16:71065627-71065627 G>A	0.0	4155	MELANOMA	-	-	-	-	HYDIN	uc031qwy.1,p.S908L|ENST00000538248,p.S935L|ENST00000321489,p.S908L|uc010vmc.2,p.S925L|uc010vmd.2,p.S935L|ENST00000393552,p.S526L|NM_001198542,p.S935L|ENST00000541601,p.S925L|NM_001270974,p.S908L|uc021tkq.2,p.S908L|uc010cfz.2,p.S653L|ENST00000393567,p.S908L|NM_001198543,p.S925L|ENST00000448691,p.S908L|NM_017558,p.S908L|ENST00000448089,p.S908L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qwy.1	nonsynonymous SNV	exon19	c.C2723T	p.S908L	PVQASGTGSTIVSDKPFAPELNLGA	PVQASGTGSTIVLDKPFAPELNLGA	3.0	1.0	-	-	4155_16:71065627-71065627 G>A_PVQASGTGSTIVLDKPFAPELNLGA	0.0
17:29559857-29559857 T>G	0.0	4317	COLORECTAL	-	-	-	1	NF1	ENST00000579081,p.L1186V|uc010csn.2,p.L1012V|uc002hgg.3,p.L1152V|NM_000267,p.L1152V|ENST00000356175,p.L1152V|uc002hgi.1,p.L185V|NM_001042492,p.L1152V|ENST00000456735,p.L818V|uc002hgh.3,p.L1152V|ENST00000358273,p.L1152V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010csn.2	nonsynonymous SNV	exon24	c.T3034G	p.L1012V	SLRHCTVLAMSNLLNANVDSGLMHS	SLRHCTVLAMSNVLNANVDSGLMHS	10.0	5.0	-	-	4317_17:29559857-29559857 T>G_SLRHCTVLAMSNVLNANVDSGLMHS	0.0
3:42705819-42705819 A>C	1.0	4252	COLORECTAL	-	-	-	-	ZBTB47	NM_145166,p.K658T|ENST00000232974,p.K658T|uc003clu.2,p.K658T|ENST00000457842,p.K282T|ENST00000505904,p.K204T	protein_coding	uc003clu.2	nonsynonymous SNV	exon6	c.A1973C	p.K658T	NMKRHRRTHTGEKPYPCDVCGQRFR	NMKRHRRTHTGETPYPCDVCGQRFR	6.0	7.0	-	-	4252_3:42705819-42705819 A>C_NMKRHRRTHTGETPYPCDVCGQRFR	0.0
1:171621399-171621399 T>C	0.0	4316	COLORECTAL	-	-	-	-	MYOC	NM_000261,p.Q118R|ENST00000037502,p.Q118R|uc001ghu.3,p.Q118R	protein_coding	uc001ghu.3	nonsynonymous SNV	exon1	c.A353G	p.Q118R	QAARPQETQEGLQRELGTLRRERDQ	QAARPQETQEGLRRELGTLRRERDQ	1.0	7.0	-	-	4316_1:171621399-171621399 T>C_QAARPQETQEGLRRELGTLRRERDQ	0.0
1:33960589-33960589 G>C	0.0	3775	CERVICAL	-	-	-	-	ZSCAN20	uc009vui.3,p.R881T|NM_145238,p.R882T|ENST00000361328,p.R882T|uc001bxj.4,p.R882T	protein_coding, processed_transcript	uc009vui.3	nonsynonymous SNV	exon8	c.G2642C	p.R881T	SGEKLYECSECGRSFSKSSALISHQ	SGEKLYECSECGTSFSKSSALISHQ	4.0	9.0	-	-	3775_1:33960589-33960589 G>C_SGEKLYECSECGTSFSKSSALISHQ	0.0
5:147024496-147024496 C>T	0.0	4335	COLORECTAL	-	-	ID=COSM272830;OCCURENCE=1(large_intestine)	-	JAKMIP2	uc003loq.2,p.A334T|ENST00000333010,p.A292T|ENST00000507386,p.A334T|uc011dbx.2,p.A292T|ENST00000265272,p.A334T|uc003lor.2,p.A334T|NM_014790,p.A334T|NM_001270941,p.A334T|NM_001282282,p.A292T|uc010jgo.2,p.A334T|NM_001270934,p.A334T	retained_intron, protein_coding	uc011dbx.2	nonsynonymous SNV	exon5	c.G874A	p.A292T	QCKPLLERNKCLAKRNDELMVSLQR	QCKPLLERNKCLTKRNDELMVSLQR	5.0	8.0	-	-	4335_5:147024496-147024496 C>T_QCKPLLERNKCLTKRNDELMVSLQR	0.0
6:87994132-87994132 C>T	0.0	3903	MELANOMA	-	-	-	-	GJB7	ENST00000296882,p.D167N|uc021zcj.1,p.D167N|uc003plo.2,p.D167N|ENST00000525899,p.D167N|NM_198568,p.D167N	protein_coding, processed_transcript	uc021zcj.1	nonsynonymous SNV	exon1	c.G499A	p.D167N	IKCDLKPCPNTVDCFISKPTEKTIF	IKCDLKPCPNTVNCFISKPTEKTIF	2.0	10.0	-	-	3903_6:87994132-87994132 C>T_IKCDLKPCPNTVNCFISKPTEKTIF	0.0
1:71534983-71534983 G>A	1.0	3466	MELANOMA	-	-	ID=COSM912028,COSM912029;OCCURENCE=1(endometrium)	-	ZRANB2	NM_203350,p.S249L|ENST00000370920,p.S249L|ENST00000254821,p.S249L|uc001dft.3,p.S249L|uc001dfs.3,p.S249L|NM_005455,p.S249L	protein_coding, processed_transcript	uc001dft.3	nonsynonymous SNV	exon8	c.C746T	p.S249L	SQSRSRSSSRERSRSRGSKSRSSSR	SQSRSRSSSRERLRSRGSKSRSSSR	10.0	6.0	-	-	3466_1:71534983-71534983 G>A_SQSRSRSSSRERLRSRGSKSRSSSR	0.0
19:4817345-4817345 A>C	1.0	2369	MELANOMA	-	-	-	-	TICAM1	uc021unj.1,p.C349G|ENST00000248244,p.C349G|NM_182919,p.C349G|uc002mbi.4,p.C349G	protein_coding	uc021unj.1	nonsynonymous SNV	exon1	c.T1045G	p.C349G	SVEDTTSPNTKPCPPTPTTPETSPP	SVEDTTSPNTKPGPPTPTTPETSPP	6.0	10.0	-	-	2369_19:4817345-4817345 A>C_SVEDTTSPNTKPGPPTPTTPETSPP	0.0
8:143921899-143921899 G>T	0.0	4110	BILE DUCT	-	-	-	-	GML	uc003yxg.3,p.A16S|ENST00000522728,p.A16S|NM_002066,p.A16S|ENST00000220940,p.A16S	protein_coding	uc003yxg.3	nonsynonymous SNV	exon2	c.G46T	p.A16S	FALLLAMELPLVAASATMRAQWTYS	FALLLAMELPLVSASATMRAQWTYS	1.0	8.0	-	-	4110_8:143921899-143921899 G>T_FALLLAMELPLVSASATMRAQWTYS	0.0
8:8234159-8234159 G>A	1.0	2556	MELANOMA	-	-	-	-	SGK223	ENST00000330777,p.S587F|uc003wsh.4,p.S587F|ENST00000520004,p.S587F	protein_coding	uc003wsh.4	nonsynonymous SNV	exon2	c.C1760T	p.S587F	SSGGSSIGPQPPSQGPADPAPSCRT	SSGGSSIGPQPPFQGPADPAPSCRT	5.0	5.0	-	-	2556_8:8234159-8234159 G>A_SSGGSSIGPQPPFQGPADPAPSCRT	0.0
6:71009776-71009776 C>T	0.0	3795	MELANOMA	-	-	-	-	COL9A1	NM_001851,p.G90E|ENST00000357250,p.G90E|uc003pfg.4,p.G90E|ENST00000370496,p.G90E	retained_intron, protein_coding, processed_transcript	uc003pfg.4	nonsynonymous SNV	exon4	c.G269A	p.G90E	VGSATLQVAYKLGNNVDFRIPTRNL	VGSATLQVAYKLENNVDFRIPTRNL	4.0	7.0	-	-	3795_6:71009776-71009776 C>T_VGSATLQVAYKLENNVDFRIPTRNL	0.0
11:123989712-123989712 C>T	0.0	2556	MELANOMA	-	-	ID=COSM233752;OCCURENCE=1(skin)	-	VWA5A	ENST00000361352,p.R226W|ENST00000392744,p.R242W|NM_014622,p.R226W|ENST00000360334,p.R226W|ENST00000392748,p.R226W|ENST00000456829,p.R226W|uc001pzr.3,p.R226W|uc001pzu.3,p.R226W|uc001pzt.3,p.R226W|NM_198315,p.R226W|NM_001130142,p.R226W|uc001pzs.3,p.R226W|uc010sae.2,p.R242W|ENST00000449321,p.R226W	retained_intron, protein_coding	uc010sae.2	nonsynonymous SNV	exon7	c.C724T	p.R242W	AQVSLAAGHKFDRDVELLIYYNEVH	AQVSLAAGHKFDWDVELLIYYNEVH	3.0	2.0	-	-	2556_11:123989712-123989712 C>T_AQVSLAAGHKFDWDVELLIYYNEVH	0.0
1:10363599-10363599 A>T	0.0	4335	COLORECTAL	-	-	-	-	KIF1B	uc001aqv.4,p.R786W|ENST00000377083,p.R786W|ENST00000377093,p.R786W|NM_183416,p.R786W	retained_intron, protein_coding, processed_transcript	uc001aqv.4	nonsynonymous SNV	exon21	c.A2356T	p.R786W	YGKKDPNERDSWRAVARDVWDTVGV	YGKKDPNERDSWWAVARDVWDTVGV	9.0	4.0	-	-	4335_1:10363599-10363599 A>T_YGKKDPNERDSWWAVARDVWDTVGV	0.0
1:43240907-43240907 T>A	1.0	4189	MELANOMA	-	-	-	-	C1orf50	uc001cia.4,p.F148I|ENST00000372525,p.F148I|NM_024097,p.F148I	protein_coding, processed_transcript	uc001cia.4	nonsynonymous SNV	exon5	c.T442A	p.F148I	SPKEWGTSCPHDFLGAYKLQHDLSW	SPKEWGTSCPHDILGAYKLQHDLSW	6.0	7.0	-	-	4189_1:43240907-43240907 T>A_SPKEWGTSCPHDILGAYKLQHDLSW	0.0
6:87970666-87970666 A>G	1.0	4345	COLORECTAL	-	-	-	-	ZNF292	ENST00000369577,p.E2440G|ENST00000339907,p.E2435G|uc003plm.4,p.E2440G|NM_015021,p.E2440G	protein_coding, processed_transcript	uc003plm.4	nonsynonymous SNV	exon8	c.A7319G	p.E2440G	KRCCNSQVKETSEQEGAKNDVKDSD	KRCCNSQVKETSGQEGAKNDVKDSD	8.0	5.0	-	-	4345_6:87970666-87970666 A>G_KRCCNSQVKETSGQEGAKNDVKDSD	0.0
16:30722159-30722159 G>A	1.0	3919	MELANOMA	-	-	-	-	SRCAP	uc002dze.1,p.E407K|uc021tgn.1,p.E407K|uc002dzg.1,p.E264K|ENST00000395059,p.E407K|ENST00000262518,p.E407K|ENST00000344771,p.E407K|NM_006662,p.E407K|ENST00000380361,p.E388K	retained_intron, protein_coding, nonsense_mediated_decay	uc021tgn.1	nonsynonymous SNV	exon9	c.G1219A	p.E407K	HPDEDDEEFTANEEEAEDEEDTIAA	HPDEDDEEFTANKEEAEDEEDTIAA	9.0	7.0	-	-	3919_16:30722159-30722159 G>A_HPDEDDEEFTANKEEAEDEEDTIAA	0.0
3:113377299-113377299 G>A	1.0	3716	MELANOMA	-	-	-	-	KIAA2018	ENST00000316407,p.S1077F|uc003eal.3,p.S1021F|NM_001009899,p.S1077F|uc003eam.3,p.S1077F|ENST00000478658,p.S1077F	retained_intron, protein_coding	uc003eam.3	nonsynonymous SNV	exon7	c.C3230T	p.S1077F	HSCLPDQEVINGSLINGRQADSPMS	HSCLPDQEVINGFLINGRQADSPMS	6.0	1.0	-	-	3716_3:113377299-113377299 G>A_HSCLPDQEVINGFLINGRQADSPMS	0.0
1:233161005-233161005 C>T	0.0	3713	MELANOMA	-	-	-	-	PCNXL2	ENST00000344698,p.E150K|uc001hvl.2,p.E1498K|uc001hvk.1,p.E150K|NM_014801,p.E1498K|ENST00000258229,p.E1498K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001hvl.2	nonsynonymous SNV	exon26	c.G4492A	p.E1498K	CNAAFHLRWLTWEITQTQYILEGYS	CNAAFHLRWLTWKITQTQYILEGYS	3.0	1.0	-	-	3713_1:233161005-233161005 C>T_CNAAFHLRWLTWKITQTQYILEGYS	0.0
4:20599984-20599984 G>A	1.0	3713	MELANOMA	-	-	-	-	SLIT2	uc003gps.1,p.D1212N|ENST00000504154,p.D1220N|ENST00000503837,p.D1216N|NM_001289136,p.D1212N|ENST00000503823,p.D1212N|ENST00000273739,p.D1233N|NM_001289135,p.D1216N|uc003gpr.1,p.D1220N|NM_004787,p.D1220N	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon32	c.G3634A	p.D1212N	VELYRGRVRASYDTGSHPASAIYSV	VELYRGRVRASYNTGSHPASAIYSV	3.0	10.0	-	-	3713_4:20599984-20599984 G>A_VELYRGRVRASYNTGSHPASAIYSV	0.0
1:190067903-190067903 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	BRINP3	ENST00000367462,p.S516C|ENST00000534846,p.S414C|uc010pot.1,p.S414C|NM_199051,p.S516C|uc001gse.1,p.S516C	protein_coding, processed_transcript	uc010pot.1	nonsynonymous SNV	exon7	c.A1240T	p.S414C	TDRRIEVHAIFISNDMRLNSWFDPS	TDRRIEVHAIFICNDMRLNSWFDPS	1.0	7.0	-	-	4258_1:190067903-190067903 T>A_TDRRIEVHAIFICNDMRLNSWFDPS	0.0
1:11861304-11861304 C>A	1.0	4287	COLORECTAL	-	-	-	-	MTHFR	uc001atb.1,p.C153F|ENST00000376592,p.C130F|ENST00000418034,p.C130F|ENST00000376585,p.C171F|ENST00000376583,p.C171F|uc001atc.2,p.C130F|NM_005957,p.C130F|ENST00000376590,p.C130F	protein_coding	uc001atc.2	nonsynonymous SNV	exon3	c.G389T	p.C130F	NYCGLETILHMTCCRQRLEEITGHL	NYCGLETILHMTFCRQRLEEITGHL	5.0	6.0	-	-	4287_1:11861304-11861304 C>A_NYCGLETILHMTFCRQRLEEITGHL	0.0
1:150900253-150900253 G>C	1.0	3775	CERVICAL	-	-	-	-	SETDB1	ENST00000498193,p.E21D|ENST00000423081,p.E35D|ENST00000368963,p.E21D|uc001evv.2,p.E21D|ENST00000368964,p.E21D|ENST00000525956,p.E21D|ENST00000368969,p.E21D|ENST00000368962,p.E21D|NM_001243491,p.E21D|uc001evw.4,p.E21D|uc009wmf.2,p.E21D|NM_001145415,p.E21D|ENST00000534805,p.E21D|uc001evu.2,p.E21D|ENST00000271640,p.E21D|ENST00000448029,p.E21D|NM_012432,p.E21D|uc009wmg.2,p.E21D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009wmg.2	nonsynonymous SNV	exon2	c.G63C	p.E21D	GLDAATATVESEEIAELQQAVVEEL	GLDAATATVESEDIAELQQAVVEEL	9.0	8.0	CD8	-	3775_1:150900253-150900253 G>C_GLDAATATVESEDIAELQQAVVEEL	1.0
6:135239743-135239743 G>A	1.0	3678	MELANOMA	-	-	-	-	ALDH8A1	ENST00000460753,p.S110F|NM_170771,p.S371F|ENST00000367845,p.S371F|uc003qex.3,p.S371F|NM_001193480,p.S375F|ENST00000265605,p.S425F|NM_022568,p.S425F|uc010kgh.3,p.S203F|uc011ecx.2,p.S375F|uc003qew.3,p.S425F|ENST00000367847,p.S375F	protein_coding, nonsense_mediated_decay	uc011ecx.2	nonsynonymous SNV	exon6	c.C1124T	p.S375F	NNVKYGLAATVWSSNVGRVHRVAKK	NNVKYGLAATVWFSNVGRVHRVAKK	6.0	3.0	-	-	3678_6:135239743-135239743 G>A_NNVKYGLAATVWFSNVGRVHRVAKK	0.0
10:127504783-127504783 G>A	1.0	3466	MELANOMA	-	-	-	-	UROS	ENST00000368778,p.S37L|ENST00000368786,p.S37L|uc001lix.4,p.S37L|ENST00000368797,p.S37L|NM_000375,p.S37L|ENST00000368774,p.S37L|uc001liw.4,p.S37L	protein_coding, processed_transcript	uc001lix.4	nonsynonymous SNV	exon3	c.C110T	p.S37L	LYGLEATLIPVLSFEFLSLPSFSEK	LYGLEATLIPVLLFEFLSLPSFSEK	6.0	5.0	-	-	3466_10:127504783-127504783 G>A_LYGLEATLIPVLLFEFLSLPSFSEK	0.0
13:36180669-36180669 C>T	1.0	3998	MELANOMA	-	-	-	2	NBEA	uc010teg.1,p.P261L|ENST00000379939,p.P2465L|ENST00000400445,p.P2468L|uc010tef.2,p.P261L|NM_001204197,p.P261L|ENST00000537702,p.P261L|uc021rid.1,p.P2468L|ENST00000379922,p.P25L|uc010abi.3,p.P1124L|ENST00000540320,p.P2468L|NM_015678,p.P2468L|ENST00000310336,p.P2468L|uc010tee.1,p.P261L|uc001uvd.3,p.P25L	protein_coding, processed_transcript	uc021rid.1	nonsynonymous SNV	exon48	c.C7403T	p.P2468L	REDEVVVNDVDLPPWAKKPEDFVRI	REDEVVVNDVDLLPWAKKPEDFVRI	6.0	6.0	-	-	3998_13:36180669-36180669 C>T_REDEVVVNDVDLLPWAKKPEDFVRI	0.0
20:57428917-57428917 C>T	0.0	4245	COLORECTAL	-	-	ID=COSM2764833;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	1	GNAS	NM_001077490,p.P137L|ENST00000306120,p.P136L	retained_intron, protein_coding, processed_transcript	NM_001077490	nonsynonymous SNV	exon1	c.C410T	p.P137L	EAQVLQGSPELLPRSPKPSGLQRLA	EAQVLQGSPELLLRSPKPSGLQRLA	10.0	6.0	-	-	4245_20:57428917-57428917 C>T_EAQVLQGSPELLLRSPKPSGLQRLA	0.0
3:100014010-100014010 C>A	1.0	2359	MELANOMA	-	-	-	-	TBC1D23	uc003dts.4,p.P227Q|NM_018309,p.P227Q|ENST00000394144,p.P227Q|NM_001199198,p.P227Q|ENST00000344949,p.P227Q|uc003dtt.4,p.P227Q|ENST00000475134,p.P90Q	retained_intron, protein_coding, processed_transcript	uc003dtt.4	nonsynonymous SNV	exon6	c.C680A	p.P227Q	QAIWDGYLQQADPFFIYFLMLIILV	QAIWDGYLQQADQFFIYFLMLIILV	8.0	4.0	-	-	2359_3:100014010-100014010 C>A_QAIWDGYLQQADQFFIYFLMLIILV	0.0
4:183675710-183675710 C>T	0.0	4259	COLORECTAL	-	-	ID=COSM1053548;OCCURENCE=1(endometrium)	-	TENM3	ENST00000406950,p.A1397V|uc003ive.1,p.A810V|NM_001080477,p.A1397V|uc003ivd.1,p.A1397V|ENST00000511685,p.A1397V	retained_intron, protein_coding, processed_transcript	uc003ive.1	nonsynonymous SNV	exon15	c.C2429T	p.A810V	QVPGVEYPVGKHAVQTTLESATAIA	QVPGVEYPVGKHVVQTTLESATAIA	4.0	9.0	-	-	4259_4:183675710-183675710 C>T_QVPGVEYPVGKHVVQTTLESATAIA	0.0
21:46020525-46020525 G>T	0.0	4196	COLORECTAL	-	-	-	-	KRTAP10-7	uc002zfn.4,p.A2S|ENST00000380102,p.A2S|NM_198689,p.A2S	protein_coding	uc002zfn.4	nonsynonymous SNV	exon1	c.G4T	p.A2S	MAASTMSVCSSDLS	MSASTMSVCSSDLS	3.0	5.0	-	-	4196_21:46020525-46020525 G>T_MSASTMSVCSSDLS	0.0
8:6302371-6302371 C>G	0.0	3713	MELANOMA	-	-	-	-	MCPH1	uc011kwl.2,p.S328R|NM_024596,p.S376R|ENST00000344683,p.S376R|uc003wqh.3,p.S376R|ENST00000519480,p.S376R|NM_001172574,p.S376R|uc003wqi.3,p.S376R|ENST00000522905,p.S328R|NM_001172575,p.S328R	protein_coding, processed_transcript	uc011kwl.2	nonsynonymous SNV	exon7	c.C984G	p.S328R	HSPPKEKCKRKRSTRRSIMPRLQLC	HSPPKEKCKRKRRTRRSIMPRLQLC	6.0	2.0	-	-	3713_8:6302371-6302371 C>G_HSPPKEKCKRKRRTRRSIMPRLQLC	0.0
16:86601315-86601315 C>T	0.0	2591	MELANOMA	-	-	-	-	FOXC2	ENST00000320354,p.S125L|uc002fjq.3,p.S125L|NM_005251,p.S125L	protein_coding	uc002fjq.3	nonsynonymous SNV	exon1	c.C374T	p.S125L	KQGWQNSIRHNLSLNECFVKVPRDD	KQGWQNSIRHNLLLNECFVKVPRDD	1.0	4.0	-	-	2591_16:86601315-86601315 C>T_KQGWQNSIRHNLLLNECFVKVPRDD	0.0
11:108381298-108381298 G>T	1.0	4252	COLORECTAL	-	-	-	-	EXPH5	ENST00000525344,p.P1639T|ENST00000265843,p.P1646T|uc001pkk.3,p.P1646T|ENST00000526312,p.P1570T|uc010rvz.2,p.P1490T|ENST00000428840,p.P1570T|NM_015065,p.P1646T|uc010rvy.2,p.P1458T|ENST00000443411,p.P1458T	protein_coding, processed_transcript	uc010rvz.2	nonsynonymous SNV	exon4	c.C4468A	p.P1490T	LGTVECNPLFPEPTPKSAESIGESR	LGTVECNPLFPETTPKSAESIGESR	6.0	9.0	-	-	4252_11:108381298-108381298 G>T_LGTVECNPLFPETTPKSAESIGESR	0.0
6:99998892-99998892 C>G	1.0	4252	COLORECTAL	-	-	-	2	CCNC	NM_001013399,p.E54Q|ENST00000523799,p.E54Q|ENST00000520371,p.E139Q|ENST00000369220,p.E139Q|uc003pqd.3,p.E54Q|ENST00000518714,p.E139Q|ENST00000326298,p.E139Q|uc010kcs.3,p.E139Q|ENST00000523985,p.E54Q|ENST00000486428,p.E85Q|uc011eah.2,p.E54Q|NM_005190,p.E139Q|ENST00000524049,p.E54Q|ENST00000520429,p.E139Q|uc003pqe.3,p.E139Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011eah.2	nonsynonymous SNV	exon6	c.G160C	p.E54Q	EFPYRMNHILECEFYLLELMDCCLI	EFPYRMNHILECQFYLLELMDCCLI	9.0	6.0	-	-	4252_6:99998892-99998892 C>G_EFPYRMNHILECQFYLLELMDCCLI	0.0
9:125281429-125281429 G>A	0.0	3795	MELANOMA	-	-	-	-	OR1J4	NM_001004452,p.E4K|uc011lyw.2,p.E4K|ENST00000340750,p.E4K	protein_coding	uc011lyw.2	nonsynonymous SNV	exon1	c.G10A	p.E4K	MKRENQSSVSEFLLLD	MKRKNQSSVSEFLLLD	1.0	9.0	-	-	3795_9:125281429-125281429 G>A_MKRKNQSSVSEFLLLD	0.0
7:6071139-6071139 G>C	1.0	4326	BREAST	-	-	-	-	ANKRD61	ENST00000409061,p.E45Q|NM_001271700,p.E45Q|uc031swn.1,p.E45Q	protein_coding	uc031swn.1	nonsynonymous SNV	exon1	c.G133C	p.E45Q	YEAIMREDCTTIEVLLRNHPVNQPI	YEAIMREDCTTIQVLLRNHPVNQPI	3.0	2.0	-	-	4326_7:6071139-6071139 G>C_YEAIMREDCTTIQVLLRNHPVNQPI	0.0
2:185800571-185800571 G>A	1.0	4000	MELANOMA	-	-	-	-	ZNF804A	ENST00000302277,p.E150K|NM_194250,p.E150K|uc002uph.3,p.E150K	protein_coding	uc002uph.3	nonsynonymous SNV	exon4	c.G448A	p.E150K	KSTTVTVRENCNEISQRVVVDSVNN	KSTTVTVRENCNKISQRVVVDSVNN	4.0	1.0	-	-	4000_2:185800571-185800571 G>A_KSTTVTVRENCNKISQRVVVDSVNN	0.0
X:129200784-129200784 C>T	1.0	3713	MELANOMA	-	-	-	1	ELF4	NM_001421,p.G635E|uc004eve.4,p.G635E|uc004evd.4,p.G635E|ENST00000335997,p.G635E|NM_001127197,p.G635E|ENST00000308167,p.G635E	protein_coding	uc004eve.4	nonsynonymous SNV	exon9	c.G1904A	p.G635E	SLLMAEPSVTTSGSLLTRSPTPAPF	SLLMAEPSVTTSESLLTRSPTPAPF	4.0	8.0	-	-	3713_X:129200784-129200784 C>T_SLLMAEPSVTTSESLLTRSPTPAPF	0.0
22:25023444-25023444 G>T	1.0	4278	COLORECTAL	-	-	ID=COSM1130480;OCCURENCE=1(prostate)	-	GGT1	uc003aau.2,p.A356S|ENST00000400383,p.A356S|uc003aav.2,p.A356S|uc003aax.2,p.A356S|NM_001288833,p.A356S|NM_013430,p.A356S|ENST00000400382,p.A356S|uc003aan.1,p.A356S|NM_013421,p.A356S|uc003aat.1,p.A356S|ENST00000406383,p.A356S|ENST00000412658,p.A356S|uc003aas.1,p.A356S|ENST00000400380,p.A356S|ENST00000248923,p.A356S|uc003aaw.2,p.A356S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003aax.2	nonsynonymous SNV	exon12	c.G1066T	p.A356S	NMTSEFFAAQLRAQISDDTTHPISY	NMTSEFFAAQLRSQISDDTTHPISY	8.0	3.0	-	-	4278_22:25023444-25023444 G>T_NMTSEFFAAQLRSQISDDTTHPISY	0.0
14:21992276-21992276 G>A	0.0	4134	NSCLC	-	-	-	-	SALL2	uc001wbe.3,p.P529L|ENST00000450879,p.P392L|NM_005407,p.P529L|uc010tly.2,p.P527L|NM_001291447,p.P392L|uc010tma.1,p.P394L|NM_001291446,p.P394L|ENST00000327430,p.P529L|uc010tlz.1,p.P392L	protein_coding	uc010tma.1	nonsynonymous SNV	exon3	c.C1181T	p.P394L	VEPKNKADENTPPGSEGSAISGVAE	VEPKNKADENTPLGSEGSAISGVAE	3.0	7.0	-	-	4134_14:21992276-21992276 G>A_VEPKNKADENTPLGSEGSAISGVAE	0.0
1:201170922-201170922 G>A	0.0	3466	MELANOMA	-	-	-	-	IGFN1	uc001gwc.3,p.D237N|NM_001164586,p.D237N|ENST00000451870,p.D237N|ENST00000335211,p.D237N|ENST00000437879,p.D237N	retained_intron, protein_coding, nonsense_mediated_decay	uc001gwc.3	nonsynonymous SNV	exon9	c.G709A	p.D237N	TKDGNAKFDLELDLKDSQSKIYLYK	TKDGNAKFDLELNLKDSQSKIYLYK	3.0	6.0	-	-	3466_1:201170922-201170922 G>A_TKDGNAKFDLELNLKDSQSKIYLYK	0.0
14:38275666-38275666 C>T	0.0	2591	MELANOMA	-	-	-	1	FOXA1,SSTR1	uc001wuj.3,p.S152L|ENST00000478811,p.S153L|ENST00000553443,p.S1422L|ENST00000382320,p.S136L	protein_coding, processed_transcript, nonsense_mediated_decay	uc001wuj.3	nonsynonymous SNV	exon5	c.C455T	p.S152L	RGLCKVKLHKDSSILDFNRAITLNP	RGLCKVKLHKDSLILDFNRAITLNP	1.0	7.0	-	-	2591_14:38275666-38275666 C>T_RGLCKVKLHKDSLILDFNRAITLNP	0.0
16:81077824-81077824 T>G	1.0	3466	MELANOMA	-	-	-	-	ATMIN	uc010vnn.1,p.M345R|uc002fga.2,p.M416R|ENST00000299575,p.M574R|uc002fgb.1,p.M416R|ENST00000566488,p.M418R|NM_001300728,p.M418R|ENST00000564241,p.M418R|uc002ffz.1,p.M574R|NM_015251,p.M574R	retained_intron, protein_coding, processed_transcript	uc010vnn.1	nonsynonymous SNV	exon3	c.T1034G	p.M345R	SAPIINFSAQNSMLPSQNMTDNQTQ	SAPIINFSAQNSRLPSQNMTDNQTQ	8.0	2.0	-	-	3466_16:81077824-81077824 T>G_SAPIINFSAQNSRLPSQNMTDNQTQ	0.0
7:88963897-88963897 C>T	0.0	4326	BREAST	-	-	ID=COSM1092764;OCCURENCE=1(endometrium)	-	ZNF804B	uc011khi.2,p.P534L|ENST00000333190,p.P534L|NM_181646,p.P534L	protein_coding	uc011khi.2	nonsynonymous SNV	exon4	c.C1601T	p.P534L	DQQKLIQEDYQYPKPKTMIANPDWE	DQQKLIQEDYQYLKPKTMIANPDWE	2.0	1.0	-	-	4326_7:88963897-88963897 C>T_DQQKLIQEDYQYLKPKTMIANPDWE	0.0
10:115595008-115595008 G>T	1.0	3784	MELANOMA	-	-	-	-	DCLRE1A	NM_014881,p.P1009H|uc001law.3,p.P1009H|uc031pxf.1,p.P1009H|ENST00000361384,p.P1009H|NM_001271816,p.P1009H|ENST00000369305,p.P1009H	protein_coding, processed_transcript	uc031pxf.1	nonsynonymous SNV	exon10	c.C3026A	p.P1009H	YLEMKRFVQWLKPQKIIPTVNVGTW	YLEMKRFVQWLKHQKIIPTVNVGTW	5.0	10.0	-	-	3784_10:115595008-115595008 G>T_YLEMKRFVQWLKHQKIIPTVNVGTW	0.0
21:38525460-38525460 C>T	1.0	2369	MELANOMA	-	-	-	-	TTC3	uc011aed.1,p.R565C|uc010gnf.3,p.R640C|uc002yvz.3,p.R875C|uc011aee.1,p.R565C|NM_001001894,p.R875C|uc002ywb.3,p.R875C|ENST00000354749,p.R875C|ENST00000540756,p.R565C|ENST00000438055,p.R857C|uc002ywa.3,p.R875C|ENST00000399017,p.R875C|ENST00000355666,p.R875C|uc002ywc.3,p.R565C|NM_003316,p.R875C|ENST00000418766,p.R875C	retained_intron, protein_coding, processed_transcript	uc011aee.1	nonsynonymous SNV	exon19	c.C1693T	p.R565C	RNFLNEAVDYVIRHLIQENNRVKTR	RNFLNEAVDYVICHLIQENNRVKTR	10.0	5.0	-	-	2369_21:38525460-38525460 C>T_RNFLNEAVDYVICHLIQENNRVKTR	0.0
X:151336822-151336822 T>G	0.0	4078	GASTRIC	-	-	ID=COSM611573;OCCURENCE=1(lung)	-	GABRA3	ENST00000535043,p.S453R|NM_000808,p.S453R|ENST00000370311,p.S453R|uc010ntk.1,p.S453R|ENST00000370314,p.S453R	protein_coding, processed_transcript	uc010ntk.1	nonsynonymous SNV	exon10	c.A1357C	p.S453R	DSPTETKTYNSVSKVDKISRIIFPV	DSPTETKTYNSVRKVDKISRIIFPV	1.0	10.0	-	-	4078_X:151336822-151336822 T>G_DSPTETKTYNSVRKVDKISRIIFPV	0.0
7:55227924-55227924 C>T	1.0	4329	COLORECTAL	-	-	-	1	EGFR	uc010kzg.2,p.S419L|NM_201284,p.S464L|uc022adm.1,p.S464L|uc003tqi.3,p.S464L|ENST00000342916,p.S464L|NM_201282,p.S464L|NM_005228,p.S464L|uc003tqk.3,p.S464L|ENST00000275493,p.S464L|uc011kco.2,p.S411L|ENST00000344576,p.S464L|ENST00000454757,p.S411L|uc022adn.1,p.S419L|ENST00000442591,p.S464L|uc003tqj.3,p.S464L|ENST00000455089,p.S419L	retained_intron, protein_coding, processed_transcript	uc022adn.1	nonsynonymous SNV	exon11	c.C1256T	p.S419L	SLKEISDGDVIISGNKNLCYANTIN	SLKEISDGDVIILGNKNLCYANTIN	9.0	2.0	-	-	4329_7:55227924-55227924 C>T_SLKEISDGDVIILGNKNLCYANTIN	0.0
8:144993982-144993982 G>A	1.0	4266	COLORECTAL	-	-	-	-	PLEC	NM_201380,p.T3473M|ENST00000398774,p.T3304M|ENST00000357649,p.T3340M|NM_201383,p.T3340M|ENST00000354589,p.T3336M|ENST00000354958,p.T3314M|NM_201378,p.T3322M|uc003zad.2,p.T3336M|uc003zaj.2,p.T3363M|NM_201382,p.T3336M|ENST00000356346,p.T3322M|ENST00000345136,p.T3336M|uc003zab.1,p.T3336M|ENST00000322810,p.T3473M|NM_201379,p.T3314M|uc003zah.2,p.T3322M|NM_201381,p.T3304M|ENST00000527096,p.T3359M|NM_000445,p.T3363M|NM_201384,p.T3336M|ENST00000436759,p.T3363M|uc003zae.1,p.T3304M|uc003zaf.1,p.T3473M|uc003zac.1,p.T3340M|uc003zag.1,p.T3314M	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon33	c.C10088T	p.T3363M	SRAQFEQLKDGKTTVKDLSELGSVR	SRAQFEQLKDGKMTVKDLSELGSVR	10.0	2.0	-	-	4266_8:144993982-144993982 G>A_SRAQFEQLKDGKMTVKDLSELGSVR	0.0
17:11461593-11461593 C>A	0.0	4213	COLORECTAL	-	-	-	-	SHISA6	ENST00000441885,p.T543K|uc002gnc.2,p.T543K|NM_001173461,p.T492K|ENST00000432116,p.T524K|uc002gna.4,p.T492K|uc010con.3,p.T222K|NM_001173462,p.T524K|uc010com.3,p.T524K|ENST00000409168,p.T492K|NM_207386,p.T543K	retained_intron, protein_coding	uc010con.3	nonsynonymous SNV	exon2	c.C665A	p.T222K	QLHYIPGHHTCYTASKTEVTV	QLHYIPGHHTCYKASKTEVTV	3.0	6.0	-	-	4213_17:11461593-11461593 C>A_QLHYIPGHHTCYKASKTEVTV	0.0
7:18687612-18687612 C>T	0.0	4240	BREAST	-	-	-	-	HDAC9	uc011jye.2,p.L383F|uc003suh.3,p.L411F|uc003sue.3,p.L411F|ENST00000432645,p.L411F|NM_001204145,p.L367F|ENST00000428307,p.L367F|NM_178425,p.L414F|uc010kud.2,p.L414F|NM_001204148,p.L383F|NM_001204144,p.L409F|uc003sud.2,p.L411F|NM_001204147,p.L334F|uc011jyb.2,p.L367F|ENST00000524023,p.L334F|ENST00000406072,p.L398F|uc010kue.1,p.L154F|uc003sua.1,p.L389F|NM_058176,p.L411F|uc011jyd.2,p.L411F|uc011jyc.2,p.L370F|uc003suf.2,p.L442F|ENST00000441542,p.L414F|ENST00000401921,p.L370F|NM_014707,p.L411F|ENST00000417496,p.L409F|uc003suj.3,p.L370F|NM_001204146,p.L370F|uc011jya.2,p.L409F|NM_178423,p.L411F|ENST00000405010,p.L411F|ENST00000456174,p.L383F|uc003sui.3,p.L414F|ENST00000406451,p.L411F|uc011jyf.2,p.L334F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jyf.2	nonsynonymous SNV	exon8	c.C1000T	p.L334F	LLLKEQMRQQKLLVAGGVPLHPQSP	LLLKEQMRQQKLFVAGGVPLHPQSP	4.0	10.0	-	-	4240_7:18687612-18687612 C>T_LLLKEQMRQQKLFVAGGVPLHPQSP	0.0
2:31010119-31010119 G>A	1.0	4196	COLORECTAL	-	-	-	-	CAPN13	ENST00000458085,p.R25W|ENST00000295055,p.R25W|uc021vfm.1,p.R25W|ENST00000534090,p.R25W|NM_144575,p.R25W|ENST00000485248,p.R25W|uc002rnp.1,p.R25W|uc021vfn.1,p.R25W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vfn.1	nonsynonymous SNV	exon1	c.C73T	p.R25W	IIKFKDQDFTTLRDHCLSMGRTFKD	IIKFKDQDFTTLWDHCLSMGRTFKD	7.0	10.0	-	-	4196_2:31010119-31010119 G>A_IIKFKDQDFTTLWDHCLSMGRTFKD	0.0
7:27839678-27839678 T>G	1.0	4252	COLORECTAL	-	-	-	-	TAX1BP1	ENST00000433216,p.L421R|NM_001079864,p.L578R|uc003szk.3,p.L578R|uc003szl.3,p.L578R|uc011jzp.2,p.L421R|ENST00000396319,p.L578R|NM_001206902,p.L421R|ENST00000265393,p.L578R|uc011jzo.2,p.L578R|ENST00000543117,p.L578R|NM_001206901,p.L578R|NM_006024,p.L578R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jzp.2	nonsynonymous SNV	exon12	c.T1262G	p.L421R	WKEQVKIAENVKLELAEVQDNYKEL	WKEQVKIAENVKRELAEVQDNYKEL	10.0	10.0	-	-	4252_7:27839678-27839678 T>G_WKEQVKIAENVKRELAEVQDNYKEL	0.0
5:79331430-79331430 G>A	0.0	4335	COLORECTAL	-	-	-	-	THBS4	uc021yaw.1,p.A24T|NM_003248,p.A24T|ENST00000350881,p.A24T	protein_coding, processed_transcript	uc021yaw.1	nonsynonymous SNV	exon1	c.G70A	p.A24T	LHLVLQRWLAAGAQATPQVFDLLPS	LHLVLQRWLAAGTQATPQVFDLLPS	5.0	7.0	-	-	4335_5:79331430-79331430 G>A_LHLVLQRWLAAGTQATPQVFDLLPS	0.0
11:117784576-117784576 G>A	1.0	4196	COLORECTAL	-	-	-	-	TMPRSS13	NM_001077263,p.S242F|uc001pru.2,p.S242F|uc001prs.2,p.S242F|uc021qrc.1,p.S242F|ENST00000528626,p.S207F|ENST00000430170,p.S242F|ENST00000524993,p.S242F|ENST00000526090,p.S242F|ENST00000445164,p.S242F|NM_001206789,p.S207F|NM_001244995,p.S242F|NM_001206790,p.S242F|uc009yzr.2,p.S207F	retained_intron, protein_coding, nonsense_mediated_decay	uc021qrc.1	nonsynonymous SNV	exon5	c.C725T	p.S242F	DWDKSLLKIYSGSSHQWLPICSSNW	DWDKSLLKIYSGFSHQWLPICSSNW	8.0	8.0	-	-	4196_11:117784576-117784576 G>A_DWDKSLLKIYSGFSHQWLPICSSNW	0.0
20:9402041-9402041 G>A	1.0	3713	MELANOMA	-	-	ID=COSM1029364;OCCURENCE=2(endometrium)	-	PLCB4	ENST00000378493,p.R739Q|ENST00000378473,p.R751Q|uc021wal.1,p.R739Q|uc010gbx.3,p.R751Q|ENST00000414679,p.R751Q|uc002wnh.3,p.R586Q|ENST00000378501,p.R739Q|ENST00000334005,p.R739Q|uc010gbw.1,p.R739Q|NM_001172646,p.R751Q|NM_182797,p.R739Q|NM_000933,p.R739Q|ENST00000278655,p.R739Q|uc021wam.1,p.R739Q	protein_coding, processed_transcript	uc021wam.1	nonsynonymous SNV	exon23	c.G2216A	p.R739Q	YGLPTDTIRKEFRTRMVMNNGLNPV	YGLPTDTIRKEFQTRMVMNNGLNPV	1.0	9.0	-	-	3713_20:9402041-9402041 G>A_YGLPTDTIRKEFQTRMVMNNGLNPV	0.0
3:184021823-184021823 T>A	1.0	3879	MELANOMA	-	-	-	-	PSMD2	NM_001278708,p.L341H|NM_001278709,p.L312H|uc003fnn.1,p.L471H|NM_002808,p.L471H|uc011brk.1,p.L341H|ENST00000435761,p.L312H|uc011brj.1,p.L312H|ENST00000439383,p.L341H|ENST00000310118,p.L471H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011brk.1	nonsynonymous SNV	exon9	c.T1022A	p.L341H	CDPALALLSDYVLHNSNTMRLGSIF	CDPALALLSDYVHHNSNTMRLGSIF	9.0	10.0	-	-	3879_3:184021823-184021823 T>A_CDPALALLSDYVHHNSNTMRLGSIF	0.0
6:69758172-69758172 T>C	0.0	4213	COLORECTAL	-	-	-	-	BAI3	ENST00000370598,p.S735P|uc003pev.4,p.S735P|NM_001704,p.S735P|uc010kak.3,p.S735P	protein_coding	uc010kak.3	nonsynonymous SNV	exon13	c.T2203C	p.S735P	KGRKGMVDWARNSEDRVVIPKSIFT	KGRKGMVDWARNPEDRVVIPKSIFT	4.0	5.0	-	-	4213_6:69758172-69758172 T>C_KGRKGMVDWARNPEDRVVIPKSIFT	0.0
17:7578550-7578550 G>A	1.0	3466	MELANOMA	-	-	ID=COSM216414,COSM3378368,COSM44226,COSM216412,COSM216413,COSM1637542;OCCURENCE=5(ovary),2(small_intestine),6(skin),3(large_intestine),1(biliary_tract),1(urinary_tract),3(pancreas),1(stomach),3(central_nervous_system),2(oesophagus),2(upper_aerodigestive_tract),1(bone),1(thyroid),1(lung)	1	TP53	NM_001126113,p.S127F|uc002gij.3,p.S88F|NM_001276761,p.S88F|ENST00000413465,p.S127F|NM_001276760,p.S88F|ENST00000508793,p.S127F|uc002gih.3,p.S127F|NM_001276695,p.S88F|ENST00000455263,p.S127F|uc031qyq.1,p.S88F|ENST00000269305,p.S127F|ENST00000359597,p.S127F|NM_001126112,p.S127F|ENST00000420246,p.S127F|NM_001126118,p.S88F|NM_001276696,p.S88F|NM_001126114,p.S127F|uc010vug.3,p.S88F|uc002gig.1,p.S127F|NM_000546,p.S127F|ENST00000445888,p.S127F	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon4	c.C263T	p.S88F	HSGTAKSVTCTYSPALNKMFCQLAK	HSGTAKSVTCTYFPALNKMFCQLAK	9.0	9.0	-	-	3466_17:7578550-7578550 G>A_HSGTAKSVTCTYFPALNKMFCQLAK	0.0
9:135073594-135073594 A>T	0.0	4329	COLORECTAL	-	-	-	-	NTNG2	ENST00000393228,p.E152V|ENST00000360670,p.E152V|NM_032536,p.E152V|uc004cbh.2,p.E152V|ENST00000393229,p.E152V|ENST00000372179,p.E152V	protein_coding, processed_transcript	uc004cbh.2	nonsynonymous SNV	exon3	c.A455T	p.E152V	TFEYGRPTVMVLEKSLDNGRTWQPY	TFEYGRPTVMVLVKSLDNGRTWQPY	3.0	3.0	-	-	4329_9:135073594-135073594 A>T_TFEYGRPTVMVLVKSLDNGRTWQPY	0.0
9:79520866-79520866 A>-	0.0	4081	COLORECTAL	-	-	-	-	PRUNE2	NM_015225,p.L5fs|ENST00000376713,p.L5fs|uc010mpk.3,p.L5fs|ENST00000376718,p.L5fs|uc004akn.3,p.L5fs	protein_coding, processed_transcript	uc010mpk.3	frameshift deletion	exon1	c.14delT	p.L5fs	MEEFLQRAKSKLNRSKR	MEEFCNAPNLN	8.0	4.0	-	-	4081_9:79520866-79520866 A>-_MEEFCNAPNLN	0.0
8:98943714-98943714 G>A	1.0	3309	MELANOMA	-	-	-	-	MATN2	uc003yic.3,p.E226K|uc010mbh.1,p.E226K|uc003yie.1,p.E226K|ENST00000524308,p.E226K|uc010mbi.1,p.E100K|uc003yib.1,p.E226K|NM_030583,p.E226K|ENST00000521689,p.E226K|ENST00000520016,p.E226K|uc003yid.3,p.E226K|NM_002380,p.E226K|ENST00000254898,p.E226K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010mbi.1	nonsynonymous SNV	exon1	c.G298A	p.E100K	DHVFLVANFSQIETLTSVFQKKLCT	DHVFLVANFSQIKTLTSVFQKKLCT	6.0	5.0	CD8	-	3309_8:98943714-98943714 G>A_DHVFLVANFSQIKTLTSVFQKKLCT	1.0
2:238274357-238274357 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM3391594;OCCURENCE=1(pancreas)	-	COL6A3	ENST00000409809,p.S1735L|uc002vwo.2,p.S1735L|ENST00000347401,p.S1740L|uc010znj.1,p.S1334L|uc002vwl.2,p.S1941L|NM_057166,p.S1334L|ENST00000353578,p.S1735L|ENST00000346358,p.S1741L|ENST00000295550,p.S1941L|ENST00000472056,p.S1334L|NM_057167,p.S1735L|NM_004369,p.S1941L	retained_intron, protein_coding, processed_transcript	uc010znj.1	nonsynonymous SNV	exon9	c.C4001T	p.S1334L	TLKVYLNKFRQSSPDSVKVVIHFTD	TLKVYLNKFRQSLPDSVKVVIHFTD	10.0	8.0	-	-	4284_2:238274357-238274357 G>A_TLKVYLNKFRQSLPDSVKVVIHFTD	0.0
20:7982177-7982177 G>A	0.0	4158	COLORECTAL	-	-	-	-	TMX4	uc002wmx.1,p.R102C|NM_021156,p.R102C|ENST00000246024,p.R102C	protein_coding, processed_transcript, nonsense_mediated_decay	uc002wmx.1	nonsynonymous SNV	exon3	c.C304T	p.R102C	KVDVIQEPGLSGRFFVTTLPAFFHA	KVDVIQEPGLSGCFFVTTLPAFFHA	7.0	10.0	-	-	4158_20:7982177-7982177 G>A_KVDVIQEPGLSGCFFVTTLPAFFHA	0.0
8:75757638-75757638 C>T	0.0	4316	COLORECTAL	-	-	ID=COSM1101600;OCCURENCE=1(endometrium),1(ovary)	-	PI15	uc003yal.3,p.R183W|uc003yam.3,p.R183W|NM_015886,p.R183W|ENST00000260113,p.R183W|ENST00000523773,p.R183W	protein_coding	uc003yam.3	nonsynonymous SNV	exon4	c.C547T	p.R183W	THYTQMVWATSNRIGCAIHTCQNMN	THYTQMVWATSNWIGCAIHTCQNMN	2.0	9.0	-	-	4316_8:75757638-75757638 C>T_THYTQMVWATSNWIGCAIHTCQNMN	0.0
20:585303-585303 G>A	0.0	4245	COLORECTAL	-	-	-	-	TCF15	NM_004609,p.R178C|ENST00000246080,p.R178C|uc002wdz.3,p.R178C	protein_coding	uc002wdz.3	nonsynonymous SNV	exon2	c.C532T	p.R178C	TFCLSNQRKGGGRRDLGGSCLKVRG	TFCLSNQRKGGGCRDLGGSCLKVRG	4.0	3.0	-	-	4245_20:585303-585303 G>A_TFCLSNQRKGGGCRDLGGSCLKVRG	0.0
3:440025-440025 T>A	0.0	4278	COLORECTAL	-	-	-	-	CHL1	uc003bou.3,p.D1054E|ENST00000256509,p.D1070E|uc003bot.3,p.D1070E|NM_006614,p.D1070E|NM_001253387,p.D1054E|uc003bow.2,p.D1054E|ENST00000397491,p.D1054E	protein_coding, processed_transcript, nonsense_mediated_decay	uc003bow.2	nonsynonymous SNV	exon24	c.T3162A	p.D1054E	EHIVRLMTKNWGDNDSIFQDVIETR	EHIVRLMTKNWGENDSIFQDVIETR	7.0	10.0	-	-	4278_3:440025-440025 T>A_EHIVRLMTKNWGENDSIFQDVIETR	0.0
X:84526097-84526097 C>T	0.0	3903	MELANOMA	-	-	-	-	ZNF711	uc004eeo.3,p.P517S|ENST00000276123,p.P517S|ENST00000360700,p.P563S|uc004eep.3,p.P517S|uc004eeq.3,p.P563S|ENST00000373165,p.P517S|ENST00000542798,p.P359S|uc011mqy.1,p.P116S|ENST00000395402,p.P525S|NM_021998,p.P517S	protein_coding	uc011mqy.1	nonsynonymous SNV	exon3	c.C346T	p.P116S	HVCVECGKGFRHPSELKKHMRTHTG	HVCVECGKGFRHSSELKKHMRTHTG	2.0	10.0	-	-	3903_X:84526097-84526097 C>T_HVCVECGKGFRHSSELKKHMRTHTG	0.0
12:33560007-33560007 C>T	0.0	3903	MELANOMA	-	-	-	-	SYT10	ENST00000228567,p.G265E|ENST00000535526,p.G84E|uc001rll.1,p.G265E|uc009zju.1,p.G75E|NM_198992,p.G265E	protein_coding, processed_transcript, nonsense_mediated_decay	uc009zju.1	nonsynonymous SNV	exon5	c.G224A	p.G75E	IKALDLPAKDFTGTSDPYVKMYLLP	IKALDLPAKDFTETSDPYVKMYLLP	1.0	3.0	-	-	3903_12:33560007-33560007 C>T_IKALDLPAKDFTETSDPYVKMYLLP	0.0
10:127417654-127417654 A>G	0.0	4246	COLORECTAL	-	-	-	-	EDRF1	ENST00000481600,p.N292S|NM_001202438,p.N292S|ENST00000368815,p.N292S|uc001liq.1,p.N292S|ENST00000356792,p.N292S|ENST00000419769,p.N292S	retained_intron, protein_coding, nonsense_mediated_decay	uc001liq.1	nonsynonymous SNV	exon7	c.A875G	p.N292S	SAPKEQNLITLFNDGEHSQGLKNDF	SAPKEQNLITLFSDGEHSQGLKNDF	7.0	10.0	-	-	4246_10:127417654-127417654 A>G_SAPKEQNLITLFSDGEHSQGLKNDF	0.0
19:46289292-46289292 G>A	1.0	4240	BREAST	-	-	-	-	DMWD	NM_004943,p.R488C|uc002pdj.1,p.R488C|ENST00000270223,p.R488C|uc010eko.1,p.R173C|ENST00000377735,p.R488C	retained_intron, protein_coding, processed_transcript	uc010eko.1	nonsynonymous SNV	exon1	c.C517T	p.R173C	SRGGEPGPGPLPRSLSRSNSLPHPA	SRGGEPGPGPLPCSLSRSNSLPHPA	8.0	7.0	-	-	4240_19:46289292-46289292 G>A_SRGGEPGPGPLPCSLSRSNSLPHPA	0.0
X:54836471-54836471 C>T	0.0	4301	MELANOMA	-	-	-	-	MAGED2	ENST00000375060,p.T83I|NM_177433,p.T121I|uc004dtl.1,p.T121I|ENST00000343474,p.T103I|ENST00000375062,p.T83I|uc004dtk.1,p.T121I|ENST00000347546,p.T65I|NM_201222,p.T121I|NM_014599,p.T121I|uc004dtm.1,p.T83I|uc004dto.1,p.T95I|ENST00000375068,p.T121I|ENST00000396224,p.T121I|uc004dtn.1,p.T121I|ENST00000375058,p.T121I|ENST00000375053,p.T121I|ENST00000218439,p.T121I	protein_coding, processed_transcript	uc004dto.1	nonsynonymous SNV	exon1	c.C284T	p.T95I	QNADPQAVTMPATETKKVSHVADTK	QNADPQAVTMPAIETKKVSHVADTK	10.0	2.0	-	-	4301_X:54836471-54836471 C>T_QNADPQAVTMPAIETKKVSHVADTK	0.0
20:24950962-24950962 T>G	1.0	4160	COLORECTAL	-	-	-	-	APMAP	ENST00000447138,p.K195T|uc010zsw.2,p.K195T|uc002wty.3,p.K195T|ENST00000217456,p.K195T|uc002wtz.3,p.K195T|NM_020531,p.K195T	protein_coding	uc010zsw.2	nonsynonymous SNV	exon6	c.A584C	p.K195T	KLLLSSETPIEGKNMSFVNDLTVTQ	KLLLSSETPIEGTNMSFVNDLTVTQ	10.0	1.0	CD8	-	4160_20:24950962-24950962 T>G_KLLLSSETPIEGTNMSFVNDLTVTQ	1.0
6:12120747-12120747 C>T	1.0	3713	MELANOMA	-	-	-	-	HIVEP1	NM_002114,p.S240L|ENST00000379388,p.S240L|uc003nac.3,p.S240L	protein_coding, nonsense_mediated_decay	uc003nac.3	nonsynonymous SNV	exon4	c.C719T	p.S240L	KTARSPPKLKNSSMDAPNQTSQELV	KTARSPPKLKNSLMDAPNQTSQELV	7.0	2.0	-	-	3713_6:12120747-12120747 C>T_KTARSPPKLKNSLMDAPNQTSQELV	0.0
3:9882455-9882455 G>A	1.0	3713	MELANOMA	-	-	-	-	RPUSD3	NM_001142547,p.P133S|NM_173659,p.P148S|uc011atl.2,p.P133S|uc011atk.2,p.P148S|ENST00000383820,p.P148S|ENST00000424438,p.P116S|uc011atm.1,p.P140S|ENST00000418713,p.P144S|ENST00000433535,p.P133S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011atm.1	nonsynonymous SNV	exon5	c.C418T	p.P140S	KESSGLVLLSSCPQTASRLQKYFTH	KESSGLVLLSSCSQTASRLQKYFTH	9.0	8.0	-	-	3713_3:9882455-9882455 G>A_KESSGLVLLSSCSQTASRLQKYFTH	0.0
5:154305535-154305535 A>G	1.0	4335	COLORECTAL	-	-	-	-	GEMIN5	ENST00000285873,p.S394P|uc011ddk.1,p.S393P|NM_015465,p.S394P|uc003lvx.3,p.S394P|NM_001252156,p.S393P	retained_intron, protein_coding	uc011ddk.1	nonsynonymous SNV	exon8	c.T1177C	p.S393P	AYSLAFSSVDIGSLAIGVGDGMIRV	AYSLAFSSVDIGPLAIGVGDGMIRV	5.0	1.0	-	-	4335_5:154305535-154305535 A>G_AYSLAFSSVDIGPLAIGVGDGMIRV	0.0
1:82447589-82447589 T>A	1.0	4284	COLORECTAL	-	-	-	-	LPHN2	uc009wcd.3,p.Y1054N|ENST00000370721,p.Y992N|NM_001297704,p.Y1054N|ENST00000370713,p.Y1054N|ENST00000370727,p.Y1082N|ENST00000370715,p.Y1054N|uc001div.3,p.Y1054N|uc001diu.3,p.Y1054N|ENST00000271029,p.Y1082N|ENST00000370725,p.Y1082N|uc009wce.1,p.Y155N|ENST00000394879,p.Y1069N|ENST00000359929,p.Y1054N|NM_001297706,p.Y1054N|NM_001297705,p.Y1054N|ENST00000370717,p.Y1082N|uc001dit.4,p.Y1054N|ENST00000319517,p.Y1054N|ENST00000370728,p.Y1067N|uc001diw.3,p.Y638N|NM_012302,p.Y1054N|ENST00000370730,p.Y1067N|ENST00000335786,p.Y1067N|ENST00000370723,p.Y1069N	protein_coding, processed_transcript	uc009wce.1	nonsynonymous SNV	exon5	c.T463A	p.Y155N	LLFINEETIVMAYLFTIFNAFQGVF	LLFINEETIVMANLFTIFNAFQGVF	7.0	6.0	-	-	4284_1:82447589-82447589 T>A_LLFINEETIVMANLFTIFNAFQGVF	0.0
16:77398264-77398264 G>A	0.0	3998	MELANOMA	-	-	-	-	ADAMTS18	ENST00000449265,p.S266F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000449265	nonsynonymous SNV	exon5	c.C797T	p.S266F	CGRRKKCICSQASHRGHLSKV	CGRRKKCICSQAFHRGHLSKV	1.0	9.0	-	-	3998_16:77398264-77398264 G>A_CGRRKKCICSQAFHRGHLSKV	0.0
X:47774811-47774811 A>C	0.0	4246	COLORECTAL	-	-	-	-	ZNF81	NM_007137,p.S256R|ENST00000376954,p.S256R|uc010nhy.2,p.S256R|uc022bvq.1,p.S256R|ENST00000338637,p.S256R	protein_coding, processed_transcript	uc022bvq.1	nonsynonymous SNV	exon5	c.A766C	p.S256R	KFCERNQCGKVLSLKHSLSQNVKFP	KFCERNQCGKVLRLKHSLSQNVKFP	6.0	2.0	-	-	4246_X:47774811-47774811 A>C_KFCERNQCGKVLRLKHSLSQNVKFP	0.0
3:48658950-48658950 C>A	1.0	4275	COLORECTAL	-	-	-	-	TMEM89	NM_001008269,p.M80I|uc011bbo.2,p.M80I|ENST00000330862,p.M80I	protein_coding	uc011bbo.2	nonsynonymous SNV	exon1	c.G240T	p.M80I	PVAAVMITTTMLMICRKILQGRRRS	PVAAVMITTTMLIICRKILQGRRRS	5.0	9.0	-	-	4275_3:48658950-48658950 C>A_PVAAVMITTTMLIICRKILQGRRRS	0.0
3:39374765-39374765 T>C	1.0	4196	COLORECTAL	-	-	-	-	CCR8	uc003cjm.2,p.F232L|ENST00000326306,p.F315L|uc010hhr.2,p.F315L|NM_005201,p.F315L|ENST00000545843,p.F232L|uc021wwe.1,p.F315L	protein_coding	uc021wwe.1	nonsynonymous SNV	exon1	c.T943C	p.F315L	VGEKFKKHLSEIFQKSCSQIFNYLG	VGEKFKKHLSEILQKSCSQIFNYLG	6.0	10.0	-	-	4196_3:39374765-39374765 T>C_VGEKFKKHLSEILQKSCSQIFNYLG	0.0
1:29356937-29356937 T>G	1.0	4317	COLORECTAL	-	-	-	-	EPB41	uc009vtl.2,p.L175V|uc009vtk.2,p.L349V|ENST00000356093,p.L384V|uc001brl.2,p.L384V|NM_001166007,p.L175V|ENST00000373800,p.L175V|uc001bri.2,p.L349V|NM_203342,p.L175V|NM_001166005,p.L384V|ENST00000347529,p.L349V|uc001brk.3,p.L384V|ENST00000398863,p.L384V|ENST00000373797,p.L384V|uc001brm.2,p.L384V|uc021okg.1,p.L384V|uc009vtm.2,p.L17V|ENST00000373798,p.L384V|ENST00000343067,p.L384V|uc001brg.2,p.L175V|NM_203343,p.L349V|NM_004437,p.L175V|ENST00000349460,p.L175V|NM_001166006,p.L384V|uc001brj.2,p.L175V|uc001brh.2,p.L175V	protein_coding, processed_transcript	uc021okg.1	nonsynonymous SNV	exon7	c.T1150G	p.L384V	KSYRSMTPAQADLEFLENAKKLSMY	KSYRSMTPAQADVEFLENAKKLSMY	10.0	2.0	-	-	4317_1:29356937-29356937 T>G_KSYRSMTPAQADVEFLENAKKLSMY	0.0
3:52960052-52960052 G>A	0.0	4155	MELANOMA	-	-	-	-	SFMBT1	uc010hmr.3,p.P323S|ENST00000358080,p.P376S|ENST00000394752,p.P376S|uc003dgh.3,p.P376S|NM_016329,p.P376S|ENST00000296295,p.P376S|ENST00000394750,p.P376S	retained_intron, protein_coding, processed_transcript	uc010hmr.3	nonsynonymous SNV	exon7	c.C967T	p.P323S	QCGAEAAPQRCFPPLISEHEFKENM	QCGAEAAPQRCFSPLISEHEFKENM	8.0	4.0	-	-	4155_3:52960052-52960052 G>A_QCGAEAAPQRCFSPLISEHEFKENM	0.0
11:75298699-75298699 C>A	0.0	4326	BREAST	-	-	-	-	MAP6	uc001owu.3,p.G616V|NM_033063,p.G616V|ENST00000304771,p.G616V|ENST00000526740,p.G287V	protein_coding, processed_transcript	uc001owu.3	nonsynonymous SNV	exon4	c.G1847T	p.G616V	KDQGPIVPAPVKGEGPIVPAPVKDE	KDQGPIVPAPVKVEGPIVPAPVKDE	5.0	1.0	-	-	4326_11:75298699-75298699 C>A_KDQGPIVPAPVKVEGPIVPAPVKDE	0.0
X:153698843-153698843 G>A	1.0	3879	MELANOMA	-	-	-	-	PLXNA3	ENST00000369682,p.R1682Q|uc004flm.3,p.R1682Q|NM_017514,p.R1682Q	retained_intron, protein_coding, processed_transcript	uc004flm.3	nonsynonymous SNV	exon30	c.G5045A	p.R1682Q	DDLFETVFSTAHRGSALPLAIKYMF	DDLFETVFSTAHQGSALPLAIKYMF	4.0	10.0	-	-	3879_X:153698843-153698843 G>A_DDLFETVFSTAHQGSALPLAIKYMF	0.0
2:230652360-230652360 A>G	1.0	3919	MELANOMA	-	-	-	-	TRIP12	uc002vpy.1,p.F1274S|NM_001284215,p.F1577S|ENST00000389044,p.F1592S|ENST00000389045,p.F1274S|uc002vpw.1,p.F1544S|NM_004238,p.F1544S|uc021vxw.1,p.F1577S|NM_001284214,p.F1592S|uc002vpx.1,p.F1592S|NM_001284216,p.F1274S|ENST00000283943,p.F1544S	retained_intron, protein_coding	uc021vxw.1	nonsynonymous SNV	exon31	c.T4730C	p.F1577S	TELGKTCPFFFPFDTRQMLFYVTAF	TELGKTCPFFFPSDTRQMLFYVTAF	10.0	8.0	CD8	-	3919_2:230652360-230652360 A>G_TELGKTCPFFFPSDTRQMLFYVTAF	1.0
1:228469796-228469796 G>A	0.0	4245	COLORECTAL	-	-	-	-	OBSCN	uc001hsq.2,p.R3216H|uc001hsp.2,p.R575H|uc001hsn.4,p.R2787H|NM_052843,p.R2787H|ENST00000422127,p.R2787H|ENST00000359599,p.R1634H|ENST00000366706,p.R635H|NM_001098623,p.R2787H|NM_001271223,p.R3216H|ENST00000284548,p.R2787H|ENST00000570156,p.R3216H|uc009xez.2,p.R2787H	retained_intron, protein_coding, processed_transcript	uc009xez.2	nonsynonymous SNV	exon31	c.G8360A	p.R2787H	KTVGSSSRFQATRQGRKYILVVREA	KTVGSSSRFQATHQGRKYILVVREA	6.0	10.0	-	-	4245_1:228469796-228469796 G>A_KTVGSSSRFQATHQGRKYILVVREA	0.0
14:76249651-76249651 C>T	1.0	3713	MELANOMA	-	-	-	-	TTLL5	uc001xrz.3,p.P497S|uc010ask.2,p.P936S|ENST00000298832,p.P922S|ENST00000557636,p.P936S|uc001xrx.3,p.P922S|ENST00000556893,p.P473S|NM_015072,p.P922S|ENST00000554510,p.P431S	retained_intron, protein_coding, processed_transcript	uc010ask.2	nonsynonymous SNV	exon27	c.C2806T	p.P936S	PGPCHHSSLSQIPSAIPSMPHQPTI	PGPCHHSSLSQISSAIPSMPHQPTI	5.0	9.0	-	-	3713_14:76249651-76249651 C>T_PGPCHHSSLSQISSAIPSMPHQPTI	0.0
12:25398284-25398284 C>A	1.0	4177	PANCREATIC	-	-	ID=COSM1140133,COSM520;OCCURENCE=24(skin),10(breast),24(small_intestine),17(urinary_tract),2(genital_tract),2(kidney),1(eye),5(liver),1402(pancreas),39(prostate),110(biliary_tract),4060(large_intestine),1(autonomic_ganglia),245(ovary),4(soft_tissue),102(endometrium),13(thyroid),13(peritoneum),878(lung),6(testis),8(cervix),36(haematopoietic_and_lymphoid_tissue),2(pleura),9(gastrointestinal_tract_(site_indeterminate)),1(central_nervous_system),32(stomach),2(thymus),3(upper_aerodigestive_tract),4(oesophagus)	1	KRAS	ENST00000557334,p.G12V|ENST00000556131,p.G12V|uc001rgp.1,p.G12V|ENST00000256078,p.G12V|NM_033360,p.G12V|ENST00000311936,p.G12V|uc001rgq.1,p.G12V|NM_004985,p.G12V	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35T	p.G12V	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGAVGVGKSALTIQLI	9.0	9.0	-	-	4177_12:25398284-25398284 C>A_MTEYKLVVVGAVGVGKSALTIQLI	0.0
19:13216361-13216361 A>C	1.0	4213	COLORECTAL	-	-	-	-	TRMT1	uc010xmy.1,p.L152R|ENST00000357720,p.L548R|NM_017722,p.L548R|ENST00000221504,p.L519R|NM_001142554,p.L519R|ENST00000592062,p.L548R|uc002mwk.2,p.L519R|uc002mwl.3,p.L548R|ENST00000437766,p.L548R|uc010xmz.1,p.L334R|NM_001136035,p.L548R|uc002mwj.2,p.L548R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xmz.1	nonsynonymous SNV	exon15	c.T1001G	p.L334R	REDANPSSRQRGLKRFQANPEANWG	REDANPSSRQRGRKRFQANPEANWG	9.0	7.0	-	-	4213_19:13216361-13216361 A>C_REDANPSSRQRGRKRFQANPEANWG	0.0
8:97847356-97847356 G>T	1.0	4316	COLORECTAL	-	-	-	-	CPQ	ENST00000220763,p.V197L|NM_016134,p.V197L|uc010mbe.2,p.V197L|uc003yhw.3,p.V197L	protein_coding, processed_transcript	uc010mbe.2	nonsynonymous SNV	exon2	c.G589T	p.V197L	QYRTQGAVEAAKVGALASLIRSVAS	QYRTQGAVEAAKLGALASLIRSVAS	5.0	10.0	-	-	4316_8:97847356-97847356 G>T_QYRTQGAVEAAKLGALASLIRSVAS	0.0
15:50940897-50940897 G>A	1.0	3903	MELANOMA	-	-	-	-	TRPM7	uc001zyt.4,p.S103F|NM_017672,p.S103F|ENST00000313478,p.S103F|uc010bew.2,p.S103F|ENST00000560955,p.S103F|NM_001301212,p.S103F	retained_intron, protein_coding, processed_transcript	uc010bew.2	nonsynonymous SNV	exon4	c.C308T	p.S103F	AYGVINFQGGSHSYRAKYVRLSYDT	AYGVINFQGGSHFYRAKYVRLSYDT	7.0	3.0	-	-	3903_15:50940897-50940897 G>A_AYGVINFQGGSHFYRAKYVRLSYDT	0.0
4:661683-661683 C>G	1.0	4284	COLORECTAL	-	-	-	-	PDE6B	uc003gap.3,p.F797L|NM_001145292,p.F518L|NM_000283,p.F797L|uc011buy.2,p.F518L|NM_001145291,p.F797L|ENST00000496514,p.F797L|ENST00000429163,p.F518L|uc003gao.4,p.F797L|uc011buz.2,p.F229L|ENST00000255622,p.F797L	retained_intron, protein_coding	uc011buz.2	nonsynonymous SNV	exon9	c.C687G	p.F229L	EFSRFHEEILPMFDRLQNNRKEWKA	EFSRFHEEILPMLDRLQNNRKEWKA	7.0	5.0	-	-	4284_4:661683-661683 C>G_EFSRFHEEILPMLDRLQNNRKEWKA	0.0
16:67195814-67195816 CGC>-	1.0	4078	GASTRIC	-	-	-	-	FBXL8	ENST00000521920,p.42_43del	protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000521920	nonframeshift deletion	exon2	c.126_128del	p.42_43del	RVCRAWAAAATCSAVWHDTKIRFHP	RVCRAWAAAATCSVWHDTKIRFHPV	5.0	5.0	-	-	4078_16:67195814-67195816 CGC>-_RVCRAWAAAATCSVWHDTKIRFHPV	0.0
1:36039969-36039969 C>T	0.0	4189	MELANOMA	-	-	-	-	TFAP2E	ENST00000373235,p.L157F|uc010ohy.2,p.L157F|NM_178548,p.L157F	protein_coding	uc010ohy.2	nonsynonymous SNV	exon2	c.C469T	p.L157F	DGAHGLADAPLGLPGLAAAPGLEDL	DGAHGLADAPLGFPGLAAAPGLEDL	4.0	9.0	-	-	4189_1:36039969-36039969 C>T_DGAHGLADAPLGFPGLAAAPGLEDL	0.0
9:3898820-3898820 C>T	1.0	3713	MELANOMA	-	-	-	-	GLIS3	ENST00000324333,p.E512K|uc003zhz.1,p.E445K|NM_152629,p.E512K|uc010mhf.1,p.E61K|uc003zhw.1,p.E512K|ENST00000381971,p.E667K|NM_001042413,p.E667K|uc003zhx.1,p.E667K|uc003zhy.1,p.E445K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010mhf.1	nonsynonymous SNV	exon4	c.G181A	p.E61K	EQQARKKLRSSTELHPDLLTDCLTV	EQQARKKLRSSTKLHPDLLTDCLTV	1.0	2.0	-	-	3713_9:3898820-3898820 C>T_EQQARKKLRSSTKLHPDLLTDCLTV	0.0
1:182827922-182827922 G>A	1.0	4259	COLORECTAL	-	-	-	-	DHX9	NM_001357,p.E319K|uc001gpr.3,p.E319K|ENST00000367549,p.E319K|uc001gps.3,p.E105K	protein_coding, processed_transcript	uc001gps.3	nonsynonymous SNV	exon11	c.G313A	p.E105K	PVALNIGKLAQFEPSQRQNQVGVVP	PVALNIGKLAQFKPSQRQNQVGVVP	10.0	9.0	-	-	4259_1:182827922-182827922 G>A_PVALNIGKLAQFKPSQRQNQVGVVP	0.0
11:119290158-119290158 G>A	1.0	3713	MELANOMA	-	-	-	-	THY1	ENST00000580275,p.S132F|ENST00000284240,p.S149F|NM_006288,p.S149F|ENST00000528522,p.S149F|uc001pwr.3,p.S149F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001pwr.3	nonsynonymous SNV	exon4	c.C446T	p.S149F	AQNTSWLLLLLLSLSLLQATDFMSL	AQNTSWLLLLLLFLSLLQATDFMSL	9.0	8.0	-	-	3713_11:119290158-119290158 G>A_AQNTSWLLLLLLFLSLLQATDFMSL	0.0
11:58338132-58338132 G>A	1.0	3879	MELANOMA	-	-	-	-	LPXN	uc010rkj.2,p.S28F|uc001nmw.3,p.S23F|ENST00000395074,p.S23F|ENST00000528954,p.S28F|ENST00000530561,p.S23F|NM_004811,p.S23F|NM_001143995,p.S28F	retained_intron, protein_coding, nonsense_mediated_decay	uc010rkj.2	nonsynonymous SNV	exon2	c.C83T	p.S28F	LERSTLQDSDEYSNPAPLPLDQHSR	LERSTLQDSDEYFNPAPLPLDQHSR	3.0	10.0	-	-	3879_11:58338132-58338132 G>A_LERSTLQDSDEYFNPAPLPLDQHSR	0.0
2:80646628-80646628 C>T	1.0	3879	MELANOMA	-	-	-	2	CTNNA2	uc010yse.2,p.P398S|NM_001282599,p.P77S|NM_001282598,p.P432S|NM_001282597,p.P398S|NM_004389,p.P398S|ENST00000541047,p.P398S|ENST00000540488,p.P398S|uc010ysh.2,p.P398S|ENST00000496558,p.P398S|ENST00000466387,p.P398S|ENST00000409550,p.P63S|ENST00000402739,p.P398S|NM_001282600,p.P30S|uc010ysg.2,p.P398S|ENST00000361291,p.P432S|uc010ysi.2,p.P30S|uc010ysf.2,p.P398S|ENST00000343114,p.P77S|NM_001164883,p.P398S	retained_intron, protein_coding, processed_transcript	uc010ysi.2	nonsynonymous SNV	exon3	c.C88T	p.P30S	DHISDSFLETNVPLLVLIEAAKSGN	DHISDSFLETNVSLLVLIEAAKSGN	6.0	3.0	-	-	3879_2:80646628-80646628 C>T_DHISDSFLETNVSLLVLIEAAKSGN	0.0
7:71135066-71135066 G>C	0.0	4213	COLORECTAL	-	-	-	-	WBSCR17	uc003tvy.4,p.R459T|uc003tvz.4,p.R158T|ENST00000333538,p.R459T|NM_022479,p.R459T	protein_coding, processed_transcript	uc003tvz.4	nonsynonymous SNV	exon8	c.G473C	p.R158T	QWYLDHVYPEMRRYNNTVAYGELRN	QWYLDHVYPEMRTYNNTVAYGELRN	5.0	9.0	-	-	4213_7:71135066-71135066 G>C_QWYLDHVYPEMRTYNNTVAYGELRN	0.0
19:49713970-49713970 T>C	1.0	3713	MELANOMA	-	-	-	-	TRPM4	ENST00000252826,p.V1111A|NM_017636,p.V1111A|ENST00000355712,p.V757A|uc010yal.2,p.V757A|ENST00000427978,p.V966A|NM_001195227,p.V966A|uc002pmy.3,p.V453A|uc002pmx.3,p.V937A|uc010yak.2,p.V575A|uc010emu.3,p.V966A|uc002pmw.3,p.V1111A|uc010emv.3,p.V996A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yal.2	nonsynonymous SNV	exon17	c.T2270C	p.V757A	PQPSSPALEHFRVYLSKEAERKLLT	PQPSSPALEHFRAYLSKEAERKLLT	3.0	10.0	-	-	3713_19:49713970-49713970 T>C_PQPSSPALEHFRAYLSKEAERKLLT	0.0
9:35102710-35102710 C>T	1.0	3713	MELANOMA	-	-	-	-	STOML2	ENST00000452248,p.M52I|ENST00000356493,p.M52I|uc003zwi.3,p.M52I|NM_013442,p.M52I|uc011lou.2,p.M52I|NM_001287031,p.M52I	protein_coding, processed_transcript, nonsense_mediated_decay	uc011lou.2	nonsynonymous SNV	exon2	c.G156A	p.M52I	FVPQQEAWVVERMGRFHRILEPGLN	FVPQQEAWVVERIGRFHRILEPGLN	9.0	1.0	-	-	3713_9:35102710-35102710 C>T_FVPQQEAWVVERIGRFHRILEPGLN	0.0
1:196394996-196394996 G>T	0.0	4126	NSCLC	-	-	-	-	KCNT2	uc009wyv.1,p.D344E|NM_001287820,p.D369E|uc001gte.1,p.D369E|uc001gtf.1,p.D369E|NM_198503,p.D369E|ENST00000367433,p.D369E|ENST00000294725,p.D369E|uc009wyu.3,p.D369E|uc001gtd.1,p.D369E|NM_001287819,p.D369E|ENST00000367431,p.D369E	protein_coding, processed_transcript	uc009wyv.1	nonsynonymous SNV	exon10	c.C1032A	p.D344E	VIYLQGSALKDQDLLRAKMDDAEAC	VIYLQGSALKDQELLRAKMDDAEAC	1.0	5.0	-	-	4126_1:196394996-196394996 G>T_VIYLQGSALKDQELLRAKMDDAEAC	0.0
6:74104827-74104827 G>A	0.0	3713	MELANOMA	-	-	-	-	DDX43	NM_018665,p.E67K|ENST00000370336,p.E67K|uc003pgw.3,p.E67K|ENST00000539829,p.E67K	retained_intron, protein_coding, processed_transcript	uc003pgw.3	nonsynonymous SNV	exon1	c.G199A	p.E67K	SRPPEAVAAGHEELPLCFALKSHFV	SRPPEAVAAGHEKLPLCFALKSHFV	3.0	7.0	-	-	3713_6:74104827-74104827 G>A_SRPPEAVAAGHEKLPLCFALKSHFV	0.0
8:77764324-77764324 C>T	1.0	2556	MELANOMA	-	-	-	-	ZFHX4	ENST00000521891,p.P1723S|ENST00000050961,p.P1678S|uc003yaw.1,p.P1678S|uc003yau.2,p.P1723S|ENST00000518282,p.P1697S|NM_024721,p.P1723S|ENST00000455469,p.P1678S	retained_intron, protein_coding, nonsense_mediated_decay	uc003yaw.1	nonsynonymous SNV	exon9	c.C5032T	p.P1678S	PQFLNPAFLPHFPMTPEALLQFQQP	PQFLNPAFLPHFSMTPEALLQFQQP	6.0	7.0	-	-	2556_8:77764324-77764324 C>T_PQFLNPAFLPHFSMTPEALLQFQQP	0.0
7:103841329-103841329 A>C	1.0	4189	MELANOMA	-	-	-	-	ORC5	ENST00000447452,p.N81K|NM_181747,p.N81K|ENST00000297431,p.N81K|uc003vcc.3,p.N81K|uc003vcb.3,p.N81K|NM_002553,p.N81K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vcc.3	nonsynonymous SNV	exon3	c.T243G	p.N81K	LRLLLEQILNKLNHLSSSEDGCSTE	LRLLLEQILNKLKHLSSSEDGCSTE	7.0	6.0	-	-	4189_7:103841329-103841329 A>C_LRLLLEQILNKLKHLSSSEDGCSTE	0.0
X:105881057-105881057 G>T	0.0	4259	COLORECTAL	-	-	-	-	CXorf57	uc004emi.4,p.K492N|ENST00000461251,p.K492N|ENST00000372548,p.K492N|NM_018015,p.K492N|uc004emh.2,p.K492N	protein_coding, processed_transcript, nonsense_mediated_decay	uc004emi.4	nonsynonymous SNV	exon8	c.G1476T	p.K492N	AKVKNFIQWIRTKSDSGEQKNMVIG	AKVKNFIQWIRTNSDSGEQKNMVIG	6.0	2.0	-	-	4259_X:105881057-105881057 G>T_AKVKNFIQWIRTNSDSGEQKNMVIG	0.0
19:11152082-11152082 C>T	1.0	3466	MELANOMA	-	-	-	1	SMARCA4	uc002mqj.4,p.P1394S|NM_001128845,p.P1394S|NM_001128847,p.P1391S|ENST00000358026,p.P1456S|uc010dxq.3,p.P1391S|ENST00000589677,p.P1394S|ENST00000429416,p.P1424S|ENST00000450717,p.P1394S|ENST00000344626,p.P1424S|NM_001128844,p.P1424S|uc002mqh.4,p.P514S|NM_001128848,p.P1391S|ENST00000538456,p.P306S|NM_001128846,p.P1394S|NM_001128849,p.P1456S|ENST00000444061,p.P1391S|uc010dxo.3,p.P1456S|ENST00000413806,p.P1394S|NM_003072,p.P1424S|ENST00000590574,p.P1391S|ENST00000592158,p.P117S|uc002mqf.4,p.P1424S|uc010dxp.3,p.P1424S|uc010dxs.3,p.P1394S|uc010dxr.3,p.P1391S|ENST00000541122,p.P1394S	retained_intron, protein_coding, processed_transcript	uc010dxs.3	nonsynonymous SNV	exon28	c.C4180T	p.P1394S	KRKRDSDAGSSTPTTSTRSRDKDDE	KRKRDSDAGSSTSTTSTRSRDKDDE	10.0	2.0	-	-	3466_19:11152082-11152082 C>T_KRKRDSDAGSSTSTTSTRSRDKDDE	0.0
11:100999685-100999685 G>T	0.0	4326	BREAST	-	-	-	-	PGR	ENST00000263463,p.S39R|ENST00000526300,p.S39R|uc001pgh.2,p.S39R|ENST00000534780,p.S39R|ENST00000528960,p.S39R|ENST00000325455,p.S39R|NM_000926,p.S39R	retained_intron, protein_coding, nonsense_mediated_decay	uc001pgh.2	nonsynonymous SNV	exon1	c.C117A	p.S39R	LLCRPAAGPFPGSQTSDTLPEVSAI	LLCRPAAGPFPGRQTSDTLPEVSAI	2.0	9.0	-	-	4326_11:100999685-100999685 G>T_LLCRPAAGPFPGRQTSDTLPEVSAI	0.0
9:16435575-16435575 G>A	1.0	3716	MELANOMA	-	-	-	-	BNC2	uc011lmv.2,p.P699S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011lmv.2	nonsynonymous SNV	exon3	c.C2095T	p.P699S	HVCTVAGCNAAFPSRRSRDSKRLES	HVCTVAGCNAAFSSRRSRDSKRLES	9.0	10.0	-	-	3716_9:16435575-16435575 G>A_HVCTVAGCNAAFSSRRSRDSKRLES	0.0
8:53569850-53569850 T>C	1.0	4326	BREAST	-	-	-	-	RB1CC1	ENST00000539297,p.I847V|ENST00000435644,p.I847V|ENST00000025008,p.I847V|NM_001083617,p.I847V|NM_014781,p.I847V|uc003xrf.4,p.I847V|uc003xre.4,p.I847V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xrf.4	nonsynonymous SNV	exon15	c.A2539G	p.I847V	NSLKCTAVEIRNIIEKVKCSLEITL	NSLKCTAVEIRNVIEKVKCSLEITL	7.0	2.0	-	-	4326_8:53569850-53569850 T>C_NSLKCTAVEIRNVIEKVKCSLEITL	0.0
1:203098171-203098171 C>T	1.0	4287	COLORECTAL	-	-	-	-	ADORA1	ENST00000367236,p.L68F|NM_000674,p.L68F|ENST00000309502,p.L68F|uc001gze.1,p.L68F|ENST00000337894,p.L68F|uc001gzf.1,p.L68F|NM_001048230,p.L68F|uc010pqh.1,p.L101F|ENST00000367235,p.L68F	protein_coding, processed_transcript	uc010pqh.1	nonsynonymous SNV	exon2	c.C301T	p.L101F	VAVGALVIPLAILINIGPQTYFHTC	VAVGALVIPLAIFINIGPQTYFHTC	2.0	9.0	-	-	4287_1:203098171-203098171 C>T_VAVGALVIPLAIFINIGPQTYFHTC	0.0
16:1261517-1261517 G>A	0.0	4298	COLORECTAL	-	-	ID=COSM967099,COSM967101;OCCURENCE=1(endometrium)	-	CACNA1H	uc002cku.3,p.D169N|NM_021098,p.D1463N|uc002ckv.3,p.D169N|uc002cks.3,p.D1463N|ENST00000348261,p.D1463N|NM_001005407,p.D1463N|ENST00000358590,p.D1463N|uc002ckt.3,p.D1463N|uc010brj.3,p.D169N|ENST00000565831,p.D1463N	retained_intron, protein_coding	uc010brj.3	nonsynonymous SNV	exon6	c.G505A	p.D169N	LFKGKFYYCEGPDTRNISTKAQCRA	LFKGKFYYCEGPNTRNISTKAQCRA	5.0	7.0	-	-	4298_16:1261517-1261517 G>A_LFKGKFYYCEGPNTRNISTKAQCRA	0.0
16:72993856-72993856 C>G	0.0	3775	CERVICAL	-	-	-	1	ZFHX3	NM_006885,p.E63D|ENST00000268489,p.E63D|uc002fck.3,p.E63D	retained_intron, protein_coding	uc002fck.3	nonsynonymous SNV	exon2	c.G189C	p.E63D	DSLRAPFNERLAESTASAGPPSEPA	DSLRAPFNERLADSTASAGPPSEPA	5.0	4.0	-	-	3775_16:72993856-72993856 C>G_DSLRAPFNERLADSTASAGPPSEPA	0.0
12:72290457-72290457 G>A	1.0	3903	MELANOMA	-	-	-	-	TBC1D15	ENST00000485960,p.G329R|uc009zrv.2,p.G230R|ENST00000550746,p.G346R|ENST00000393309,p.G100R|ENST00000319106,p.G337R|uc010stt.2,p.G337R|uc001sww.3,p.G100R|ENST00000491063,p.G230R|uc001swv.3,p.G329R|NM_001146214,p.G337R|NM_022771,p.G346R|NM_001146213,p.G329R|uc001swu.3,p.G346R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010stt.2	nonsynonymous SNV	exon10	c.G1009A	p.G337R	NVDNMKQMIFRGGLSHALRKQAWKF	NVDNMKQMIFRGRLSHALRKQAWKF	8.0	8.0	-	-	3903_12:72290457-72290457 G>A_NVDNMKQMIFRGRLSHALRKQAWKF	0.0
7:31793126-31793126 C>T	0.0	4275	COLORECTAL	-	-	-	-	PDE1C	ENST00000396193,p.A728T|NM_001191059,p.A668T|NM_001191058,p.A728T|uc003tcm.2,p.A668T|ENST00000321453,p.A668T|NM_001191057,p.A668T|ENST00000396191,p.A668T|uc003tco.2,p.A728T|uc003tcn.1,p.A668T	retained_intron, protein_coding, processed_transcript	uc003tco.2	nonsynonymous SNV	exon19	c.G2182A	p.A728T	KPPLRHFKRPAYASSSYAPSVSKKT	KPPLRHFKRPAYTSSSYAPSVSKKT	4.0	6.0	-	-	4275_7:31793126-31793126 C>T_KPPLRHFKRPAYTSSSYAPSVSKKT	0.0
18:21483031-21483031 C>T	1.0	4077	BILE DUCT	-	-	-	-	LAMA3	NM_198129,p.A2087V|ENST00000313654,p.A2087V|uc002kut.4,p.A422V|NM_001127717,p.A2031V|uc002kus.4,p.A478V|uc002kuq.3,p.A2087V|NM_001127718,p.A422V|NM_000227,p.A478V|ENST00000587184,p.A422V|uc002kur.3,p.A2031V|ENST00000269217,p.A478V|ENST00000399516,p.A2031V	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc002kut.4	nonsynonymous SNV	exon11	c.C1265T	p.A422V	SLQSDFTKYLTTADSSLLQTNIALQ	SLQSDFTKYLTTVDSSLLQTNIALQ	9.0	8.0	-	-	4077_18:21483031-21483031 C>T_SLQSDFTKYLTTVDSSLLQTNIALQ	0.0
4:7719909-7719909 A>G	0.0	4235	COLORECTAL	-	-	-	-	SORCS2	uc003gkb.4,p.Q808R|uc011bwi.2,p.Q636R|ENST00000507866,p.Q808R|ENST00000329016,p.Q636R|NM_020777,p.Q808R	protein_coding, processed_transcript	uc011bwi.2	nonsynonymous SNV	exon18	c.A1907G	p.Q636R	PGEDVLFVVRQEQGDVLTTKYQVDL	PGEDVLFVVRQERGDVLTTKYQVDL	4.0	2.0	-	-	4235_4:7719909-7719909 A>G_PGEDVLFVVRQERGDVLTTKYQVDL	0.0
9:134501710-134501710 G>A	1.0	3713	MELANOMA	-	-	-	-	RAPGEF1	NM_198679,p.S435F|uc022bou.1,p.S422F|ENST00000372190,p.S435F|uc022bov.1,p.S422F|NM_005312,p.S417F|ENST00000372195,p.S434F|ENST00000372189,p.S417F|uc022bot.1,p.S417F|uc022bos.1,p.S435F	protein_coding, processed_transcript	uc022bov.1	nonsynonymous SNV	exon10	c.C1265T	p.S422F	QQTAWNLSPLPESLGESGSPFLGPP	QQTAWNLSPLPEFLGESGSPFLGPP	8.0	4.0	-	-	3713_9:134501710-134501710 G>A_QQTAWNLSPLPEFLGESGSPFLGPP	0.0
6:158564153-158564153 C>G	0.0	4240	BREAST	-	-	-	-	SERAC1	ENST00000367104,p.E225Q|uc003qrc.2,p.E225Q|ENST00000606965,p.E225Q|ENST00000367102,p.E225Q|ENST00000367101,p.E225Q|NM_032861,p.E225Q	protein_coding	uc003qrc.2	nonsynonymous SNV	exon8	c.G673C	p.E225Q	QLLASLPQTELDECIQYFTSLALSE	QLLASLPQTELDQCIQYFTSLALSE	6.0	10.0	-	-	4240_6:158564153-158564153 C>G_QLLASLPQTELDQCIQYFTSLALSE	0.0
14:80971302-80971302 T>G	0.0	4126	NSCLC	-	-	-	-	CEP128	ENST00000281129,p.Q1045P|ENST00000555265,p.Q1045P|uc001xux.2,p.Q1045P|NM_152446,p.Q1045P|uc031qpo.1,p.Q1072P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qpo.1	nonsynonymous SNV	exon25	c.A3215C	p.Q1072P	SHTRGLDHSSSWQDHSRFLSSPRFS	SHTRGLDHSSSWPDHSRFLSSPRFS	4.0	3.0	-	-	4126_14:80971302-80971302 T>G_SHTRGLDHSSSWPDHSRFLSSPRFS	0.0
19:9087347-9087347 G>A	0.0	3903	MELANOMA	-	-	-	2	MUC16	ENST00000397910,p.P1490S|uc002mkp.3,p.P1490S|NM_024690,p.P1490S	protein_coding, processed_transcript, nonsense_mediated_decay	uc002mkp.3	nonsynonymous SNV	exon1	c.C4468T	p.P1490S	SPSSPMSTFAIFPPMSTPSHELSKS	SPSSPMSTFAIFSPMSTPSHELSKS	1.0	5.0	-	-	3903_19:9087347-9087347 G>A_SPSSPMSTFAIFSPMSTPSHELSKS	0.0
X:70149561-70149561 G>A	0.0	4287	COLORECTAL	-	-	-	-	SLC7A3	NM_001048164,p.S96L|uc004dyn.3,p.S96L|ENST00000374299,p.S96L|ENST00000298085,p.S96L|uc004dyo.3,p.S96L|NM_032803,p.S96L	protein_coding	uc004dyo.3	nonsynonymous SNV	exon2	c.C287T	p.S96L	YAEFGARVPRSGSAYLYSYVTVGEL	YAEFGARVPRSGLAYLYSYVTVGEL	1.0	10.0	-	-	4287_X:70149561-70149561 G>A_YAEFGARVPRSGLAYLYSYVTVGEL	0.0
X:53111841-53111841 C>T	0.0	4081	COLORECTAL	-	-	-	-	TSPYL2	ENST00000579390,p.A54V	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000579390	nonsynonymous SNV	exon1	c.C161T	p.A54V	PQQRPRLQEETEAAQIIKNDLWVNP	PQQRPRLQEETEVAQIIKNDLWVNP	5.0	5.0	-	-	4081_X:53111841-53111841 C>T_PQQRPRLQEETEVAQIIKNDLWVNP	0.0
4:2307130-2307130 G>A	1.0	3919	MELANOMA	-	-	-	-	ZFYVE28	ENST00000511071,p.P283S|uc003gew.2,p.P199S|ENST00000290974,p.P313S|uc003gex.2,p.P313S|NM_001172659,p.P243S|uc011bvk.2,p.P243S|ENST00000515312,p.P243S|uc011bvl.2,p.P283S|NM_001172656,p.P283S|NM_020972,p.P313S	retained_intron, protein_coding, processed_transcript	uc011bvl.2	nonsynonymous SNV	exon7	c.C847T	p.P283S	QGPAALAPALSAPLPPEGPLSAKAK	QGPAALAPALSASLPPEGPLSAKAK	5.0	9.0	-	-	3919_4:2307130-2307130 G>A_QGPAALAPALSASLPPEGPLSAKAK	0.0
17:1557072-1557072 ->GACC	1.0	4275	COLORECTAL	-	-	-	-	PRPF8	ENST00000304992,p.R2076fs|NM_006445,p.R2076fs|ENST00000572621,p.R2076fs|uc002fte.3,p.R2076fs	retained_intron, protein_coding, processed_transcript	uc002fte.3	frameshift insertion	exon38	c.6225_6226insGGTC	p.R2076fs	TQTFSSKTEWRVRAISAANLHLRTN	TQTFSSKTEWRVGQGHLCCQPAPKDQSHLCFI	10.0	2.0	-	-	4275_17:1557072-1557072 ->GACC_TQTFSSKTEWRVGQGHLCCQPAPKDQSHLCFI	0.0
1:26872445-26872445 G>T	0.0	4134	NSCLC	-	-	-	-	RPS6KA1	NM_001006665,p.W18C|uc001bms.1,p.W18C|ENST00000531382,p.W18C|ENST00000374163,p.W18C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001bms.1	nonsynonymous SNV	exon1	c.G54T	p.W18C	KPPRLRLWALIPWLPRKQRPRISQT	KPPRLRLWALIPCLPRKQRPRISQT	9.0	10.0	-	-	4134_1:26872445-26872445 G>T_KPPRLRLWALIPCLPRKQRPRISQT	0.0
11:118183485-118183485 G>A	0.0	2556	MELANOMA	-	-	-	-	CD3E	uc001psq.4,p.E86K|NM_000733,p.E86K|uc010rya.2,p.E86K|ENST00000361763,p.E86K|ENST00000528600,p.E80K	retained_intron, protein_coding	uc010rya.2	nonsynonymous SNV	exon6	c.G256A	p.E86K	NIGSDEDHLSLKEFSELEQSGYYVC	NIGSDEDHLSLKKFSELEQSGYYVC	1.0	10.0	-	-	2556_11:118183485-118183485 G>A_NIGSDEDHLSLKKFSELEQSGYYVC	0.0
8:144406776-144406776 G>A	1.0	4240	BREAST	-	-	-	-	TOP1MT	ENST00000523676,p.P134L|uc010mfd.2,p.P27L|uc011lke.3,p.P134L|ENST00000521193,p.P134L|ENST00000522041,p.P134L|NM_001258447,p.P134L|ENST00000519139,p.P134L|ENST00000519148,p.P134L|ENST00000329245,p.P232L|uc011lkf.2,p.P27L|NM_001258446,p.P134L|ENST00000519591,p.P134L|NM_052963,p.P232L|uc003yxz.4,p.P232L|uc011lkd.3,p.P134L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lkf.2	nonsynonymous SNV	exon2	c.C80T	p.P27L	INCSRDSKIPEPPAGHQWKEVRSDN	INCSRDSKIPEPLAGHQWKEVRSDN	10.0	9.0	-	-	4240_8:144406776-144406776 G>A_INCSRDSKIPEPLAGHQWKEVRSDN	0.0
2:152537311-152537311 T>G	0.0	4245	COLORECTAL	-	-	-	-	NEB	NM_004543,p.K992T|ENST00000603639,p.K992T|ENST00000427231,p.K992T|uc021vrd.1,p.K992T|uc021vrb.1,p.K992T|uc021vrc.1,p.K992T|NM_001271208,p.K992T|ENST00000604864,p.K992T|uc010fnx.3,p.K992T|NM_001164508,p.K992T|ENST00000409198,p.K992T|ENST00000172853,p.K992T|ENST00000397345,p.K992T|uc031rpp.1,p.K992T|NM_001164507,p.K992T|uc002txu.3,p.K992T	retained_intron, protein_coding, processed_transcript	uc031rpp.1	nonsynonymous SNV	exon30	c.A2975C	p.K992T	NEKKYRQHPDTLKFTSIEDAPITVQ	NEKKYRQHPDTLTFTSIEDAPITVQ	5.0	6.0	-	-	4245_2:152537311-152537311 T>G_NEKKYRQHPDTLTFTSIEDAPITVQ	0.0
12:64377765-64377765 G>A	1.0	4240	BREAST	-	-	-	-	SRGAP1	ENST00000357825,p.E36K|ENST00000355086,p.E36K|uc010ssp.1,p.E36K|uc001srt.3,p.E36K|NM_020762,p.E36K	retained_intron, protein_coding	uc010ssp.1	nonsynonymous SNV	exon2	c.G106A	p.E36K	IRAQLVEQQKCLEQQTEMRVQLLQD	IRAQLVEQQKCLKQQTEMRVQLLQD	8.0	7.0	-	-	4240_12:64377765-64377765 G>A_IRAQLVEQQKCLKQQTEMRVQLLQD	0.0
4:166915679-166915679 T>G	0.0	4278	COLORECTAL	-	-	ID=COSM1428406;OCCURENCE=1(large_intestine)	-	TLL1	uc011cjn.2,p.F170V|ENST00000513213,p.F170V|NM_001204760,p.F170V|uc003irh.2,p.F170V|ENST00000061240,p.F170V|ENST00000507499,p.F170V|uc021xud.1,p.F170V|NM_012464,p.F170V|ENST00000506144,p.F70V	protein_coding, nonsense_mediated_decay	uc021xud.1	nonsynonymous SNV	exon4	c.T508G	p.F170V	PGGVIPYVIGGNFTGSQRAMFKQAM	PGGVIPYVIGGNVTGSQRAMFKQAM	6.0	6.0	-	-	4278_4:166915679-166915679 T>G_PGGVIPYVIGGNVTGSQRAMFKQAM	0.0
1:224505430-224505430 C>A	1.0	4126	NSCLC	-	-	-	-	NVL	uc010pvd.2,p.A84S|uc001hok.3,p.A84S|ENST00000467882,p.A84S|ENST00000281701,p.A84S|NM_001243147,p.A84S|ENST00000469075,p.A84S|ENST00000488718,p.A84S|NM_002533,p.A84S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010pvd.2	nonsynonymous SNV	exon4	c.G250T	p.A84S	LKNLTELEDEHLAKRARQGEEDNEY	LKNLTELEDEHLSKRARQGEEDNEY	8.0	9.0	-	-	4126_1:224505430-224505430 C>A_LKNLTELEDEHLSKRARQGEEDNEY	0.0
5:171337597-171337597 C>T	1.0	3713	MELANOMA	-	-	-	-	FBXW11	ENST00000393802,p.D84N|ENST00000517395,p.D139N|uc003mbn.1,p.D84N|NM_033645,p.D84N|NM_033644,p.D105N|ENST00000265094,p.D118N|NM_012300,p.D118N|ENST00000296933,p.D105N|uc003mbl.1,p.D105N|uc011dey.1,p.D86N|ENST00000425623,p.D86N|uc003mbm.1,p.D118N	protein_coding, processed_transcript, nonsense_mediated_decay	uc011dey.1	nonsynonymous SNV	exon3	c.G256A	p.D86N	HINSYLKPMLQRDFITALPEQGLDH	HINSYLKPMLQRNFITALPEQGLDH	8.0	8.0	-	-	3713_5:171337597-171337597 C>T_HINSYLKPMLQRNFITALPEQGLDH	0.0
1:4832537-4832537 C>T	0.0	4326	BREAST	-	-	-	-	AJAP1	uc001alm.1,p.T372M|uc001aln.3,p.T372M|ENST00000378191,p.T372M|ENST00000378190,p.T372M|NM_018836,p.T372M|NM_001042478,p.T372M	protein_coding, processed_transcript	uc001aln.3	nonsynonymous SNV	exon4	c.C1115T	p.T372M	CVRASVPVYTDETLHSTTGEYKSTF	CVRASVPVYTDEMLHSTTGEYKSTF	2.0	8.0	-	-	4326_1:4832537-4832537 C>T_CVRASVPVYTDEMLHSTTGEYKSTF	0.0
17:20483760-20483760 C>G	0.0	4346	COLORECTAL	-	-	-	-	CDRT15L2	ENST00000399044,p.D188E|uc021tsn.1,p.D188E|NM_001190790,p.D188E	protein_coding	uc021tsn.1	nonsynonymous SNV	exon2	c.C564G	p.D188E	PSPGHGGKHGGGDQGIQTGLLYLAG	PSPGHGGKHGGGEQGIQTGLLYLAG	1.0	4.0	-	-	4346_17:20483760-20483760 C>G_PSPGHGGKHGGGEQGIQTGLLYLAG	0.0
6:109764243-109764243 C>G	0.0	4155	MELANOMA	-	-	-	-	SMPD2	NM_003080,p.P230A|ENST00000258052,p.P230A|uc003pti.3,p.P230A	retained_intron, protein_coding	uc003pti.3	nonsynonymous SNV	exon8	c.C688G	p.P230A	PKNCYVSQQELKPFPFGVRIDYVLY	PKNCYVSQQELKAFPFGVRIDYVLY	7.0	4.0	-	-	4155_6:109764243-109764243 C>G_PKNCYVSQQELKAFPFGVRIDYVLY	0.0
7:116340222-116340222 A>T	1.0	4134	NSCLC	-	-	-	1	MET	ENST00000436117,p.M362L|uc010lkh.3,p.M362L|uc011knh.1,p.M362L|uc011kng.1,p.M362L|NM_001127500,p.M362L|uc011kmz.1,p.M362L|uc010lkg.3,p.M362L|uc003vij.3,p.M362L|uc011kna.1,p.M362L|uc011kni.2,p.M362L|uc003vii.1,p.M381L|uc011knf.2,p.M362L|uc011knc.1,p.M362L|uc011kne.2,p.M362L|uc011knb.1,p.M362L|NM_000245,p.M362L|ENST00000397752,p.M362L|uc022akk.1,p.M362L|ENST00000318493,p.M362L|uc011knd.2,p.M362L	protein_coding, processed_transcript	uc022akk.1	nonsynonymous SNV	exon2	c.A1084T	p.M362L	KPDSAEPMDRSAMCAFPIKYVNDFF	KPDSAEPMDRSALCAFPIKYVNDFF	9.0	4.0	-	-	4134_7:116340222-116340222 A>T_KPDSAEPMDRSALCAFPIKYVNDFF	0.0
19:40886834-40886834 G>T	0.0	4278	COLORECTAL	-	-	-	-	HIPK4	uc002onp.3,p.A355D|NM_144685,p.A355D|ENST00000291823,p.A355D	protein_coding	uc002onp.3	nonsynonymous SNV	exon3	c.C1064A	p.A355D	RHPFVSMQQLRSAHETTHYYQLSLR	RHPFVSMQQLRSDHETTHYYQLSLR	3.0	5.0	-	-	4278_19:40886834-40886834 G>T_RHPFVSMQQLRSDHETTHYYQLSLR	0.0
8:28210805-28210805 G>A	1.0	2369	MELANOMA	-	-	-	-	ZNF395	NM_018660,p.P235L|ENST00000523202,p.P235L|ENST00000344423,p.P235L|ENST00000523095,p.P235L|uc003xgt.4,p.P235L|uc003xgr.3,p.P235L|uc003xgs.3,p.P235L|uc003xgq.3,p.P235L	retained_intron, protein_coding, processed_transcript	uc003xgt.4	nonsynonymous SNV	exon11	c.C704T	p.P235L	GSSGVSTPSPPHPQASPKYLGDAFG	GSSGVSTPSPPHLQASPKYLGDAFG	6.0	9.0	-	-	2369_8:28210805-28210805 G>A_GSSGVSTPSPPHLQASPKYLGDAFG	0.0
6:33164143-33164143 T>C	0.0	4126	NSCLC	-	-	-	-	RXRB	uc011dqu.2,p.Y258C|uc003ode.1,p.Y218C|ENST00000413614,p.Y258C|uc011dqt.2,p.Y354C	retained_intron, protein_coding, nonsense_mediated_decay	uc011dqu.2	nonsynonymous SNV	exon4	c.A773G	p.Y258C	VMGVGGGSLGLFYIPSPSFPLITFL	VMGVGGGSLGLFCIPSPSFPLITFL	7.0	9.0	-	-	4126_6:33164143-33164143 T>C_VMGVGGGSLGLFCIPSPSFPLITFL	0.0
1:33794623-33794623 G>A	1.0	3775	CERVICAL	-	-	-	-	PHC2	ENST00000373416,p.S222L|uc001bxf.1,p.S172L|ENST00000373422,p.S363L|uc009vuh.1,p.S758L|ENST00000257118,p.S757L|uc001bxg.1,p.S757L|NM_004427,p.S222L|uc001bxh.1,p.S729L|ENST00000431992,p.S728L|ENST00000419414,p.S758L|NM_198040,p.S757L|uc001bxe.1,p.S222L|ENST00000373418,p.S222L	protein_coding, processed_transcript	uc009vuh.1	nonsynonymous SNV	exon14	c.C2273T	p.S758L	SYEEPLSPISASSSTSRRRQGQRDL	SYEEPLSPISASLSTSRRRQGQRDL	9.0	9.0	-	-	3775_1:33794623-33794623 G>A_SYEEPLSPISASLSTSRRRQGQRDL	0.0
14:90744765-90744765 A>T	1.0	4317	COLORECTAL	-	-	-	-	NRDE2	uc001xyi.2,p.M1137K|ENST00000354366,p.M1137K|uc001xyj.2,p.M906K|uc010atp.1,p.M642K|ENST00000357904,p.M906K|NM_017970,p.M1137K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010atp.1	nonsynonymous SNV	exon10	c.T1925A	p.M642K	LYLDAVEYFPDEMQEILDLMTEKEL	LYLDAVEYFPDEKQEILDLMTEKEL	6.0	3.0	-	-	4317_14:90744765-90744765 A>T_LYLDAVEYFPDEKQEILDLMTEKEL	0.0
X:105181531-105181531 G>C	0.0	4158	COLORECTAL	-	-	-	-	NRK	ENST00000428173,p.Q1253H|uc004emd.3,p.Q1252H|uc010npc.1,p.Q920H|ENST00000243300,p.Q1252H|NM_198465,p.Q1252H	protein_coding	uc010npc.1	nonsynonymous SNV	exon22	c.G2760C	p.Q920H	DITKLIRRRPFRQIQVLEPLNLLIT	DITKLIRRRPFRHIQVLEPLNLLIT	3.0	2.0	-	-	4158_X:105181531-105181531 G>C_DITKLIRRRPFRHIQVLEPLNLLIT	0.0
10:101128428-101128428 G>C	0.0	4110	BILE DUCT	-	-	-	-	CNNM1	ENST00000370534,p.G379R|uc010qpi.2,p.G744R	protein_coding, processed_transcript	uc010qpi.2	nonsynonymous SNV	exon7	c.G2230C	p.G744R	RTFAVSRGDSLAGSPVNRSPSRCSG	RTFAVSRGDSLARSPVNRSPSRCSG	4.0	8.0	-	-	4110_10:101128428-101128428 G>C_RTFAVSRGDSLARSPVNRSPSRCSG	0.0
8:17137894-17137894 T>C	1.0	4196	COLORECTAL	-	-	-	-	VPS37A	ENST00000521829,p.L279P|uc003wxk.3,p.L279P|ENST00000324849,p.L304P|uc003wxj.3,p.L304P|ENST00000521976,p.L77P|NM_152415,p.L304P|NM_001145152,p.L279P	protein_coding, processed_transcript, nonsense_mediated_decay	uc003wxk.3	nonsynonymous SNV	exon8	c.T836C	p.L279P	AKRQTVLDKYELLTQMKSTFEKKMQ	AKRQTVLDKYELPTQMKSTFEKKMQ	8.0	5.0	-	-	4196_8:17137894-17137894 T>C_AKRQTVLDKYELPTQMKSTFEKKMQ	0.0
16:61854870-61854870 G>A	0.0	4186	BREAST	-	-	-	-	CDH8	ENST00000577730,p.S328F|ENST00000584337,p.S328F|NM_001796,p.S328F|uc002eog.2,p.S328F|ENST00000585315,p.S328F|ENST00000299345,p.S328F|ENST00000577390,p.S328F|ENST00000583382,p.S328F|uc002eoh.3,p.S97F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002eoh.3	nonsynonymous SNV	exon3	c.C290T	p.S97F	IDGDGTALFEITSDAQAQDGIIRLR	IDGDGTALFEITFDAQAQDGIIRLR	1.0	10.0	-	-	4186_16:61854870-61854870 G>A_IDGDGTALFEITFDAQAQDGIIRLR	0.0
5:52367856-52367856 C>T	1.0	4189	MELANOMA	-	-	-	-	ITGA2	ENST00000296585,p.S775F|uc003joy.3,p.S775F|NM_002203,p.S775F|uc011cqc.2,p.S699F|ENST00000510722,p.S775F|ENST00000509814,p.S775F	protein_coding, nonsense_mediated_decay	uc011cqc.2	nonsynonymous SNV	exon17	c.C2096T	p.S699F	ENPGTSPALEAYSETAKVFSIPFHK	ENPGTSPALEAYFETAKVFSIPFHK	7.0	10.0	-	-	4189_5:52367856-52367856 C>T_ENPGTSPALEAYFETAKVFSIPFHK	0.0
11:20699537-20699537 G>T	0.0	4346	COLORECTAL	-	-	-	-	NELL1	uc010rdo.2,p.V39L|NM_001288714,p.V39L|ENST00000532434,p.V39L|ENST00000357134,p.V39L|ENST00000325319,p.V39L|ENST00000298925,p.V67L|NM_001288713,p.V67L|uc001mqe.3,p.V39L|uc001mqf.3,p.V39L|NM_006157,p.V39L|NM_201551,p.V39L|uc009yid.3,p.V67L	retained_intron, protein_coding, processed_transcript	uc010rdo.2	nonsynonymous SNV	exon2	c.G115T	p.V39L	DLQMDIVTELDLVNTTLGVAQVSGM	DLQMDIVTELDLLNTTLGVAQVSGM	1.0	3.0	-	-	4346_11:20699537-20699537 G>T_DLQMDIVTELDLLNTTLGVAQVSGM	0.0
19:58117272-58117282 TTCTGGATGAG>-	0.0	4252	COLORECTAL	-	-	-	-	ZNF530	NM_020880,p.F127fs|uc002qpk.2,p.F127fs|ENST00000332854,p.F127fs|ENST00000600619,p.F127fs	retained_intron, protein_coding, nonsense_mediated_decay	uc002qpk.2	frameshift deletion	exon3	c.379_389del	p.F127fs	GQKLYLGGASRDFWMSSNLHQLQKL	GQKLYLGGASRDFKPSPAPEA	8.0	8.0	-	-	4252_19:58117272-58117282 TTCTGGATGAG>-_GQKLYLGGASRDFKPSPAPEA	0.0
9:35548146-35548146 C>T	1.0	3713	MELANOMA	-	-	-	-	RUSC2	ENST00000361226,p.S543F|uc003zwx.4,p.S543F|NM_014806,p.S543F|NM_001135999,p.S543F|ENST00000455600,p.S543F|uc003zww.3,p.S543F	protein_coding, processed_transcript	uc003zwx.4	nonsynonymous SNV	exon2	c.C1628T	p.S543F	MAGPGSPPRRVTSFAELAKGRKKTG	MAGPGSPPRRVTFFAELAKGRKKTG	5.0	3.0	-	-	3713_9:35548146-35548146 C>T_MAGPGSPPRRVTFFAELAKGRKKTG	0.0
16:460246-460246 C>T	0.0	4235	COLORECTAL	0.0005	-	-	-	DECR2	uc002chb.3,p.A114V|ENST00000424398,p.A102V|uc002chd.3,p.A30V|ENST00000219481,p.A114V|uc002chc.3,p.A30V|NM_020664,p.A114V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002chd.3	nonsynonymous SNV	exon7	c.C89T	p.A30V	KEFGRIDILINCAAGNFLCPAGALS	KEFGRIDILINCVAGNFLCPAGALS	6.0	1.0	-	-	4235_16:460246-460246 C>T_KEFGRIDILINCVAGNFLCPAGALS	0.0
4:15444302-15444302 T>G	0.0	4278	COLORECTAL	-	-	-	-	C1QTNF7	ENST00000429690,p.F250C|uc003gnp.3,p.F250C|ENST00000444304,p.F250C|ENST00000295297,p.F257C|uc011bxb.2,p.F250C|uc003gno.3,p.F257C|NM_001135171,p.F250C|NM_001135170,p.F257C|NM_031911,p.F250C	protein_coding, processed_transcript	uc011bxb.2	nonsynonymous SNV	exon3	c.T749G	p.F250C	YLQPEDEVWLEIFFTDQNGLFSDPG	YLQPEDEVWLEICFTDQNGLFSDPG	4.0	6.0	-	-	4278_4:15444302-15444302 T>G_YLQPEDEVWLEICFTDQNGLFSDPG	0.0
2:172314925-172314925 G>A	1.0	4110	BILE DUCT	-	-	-	-	DCAF17	ENST00000539783,p.G259D|ENST00000375255,p.G259D|uc002ugx.3,p.G259D|NM_025000,p.G259D|uc010fqf.2,p.G259D|NM_001164821,p.G259D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010fqf.2	nonsynonymous SNV	exon8	c.G776A	p.G259D	QQKLDLGCACRWGGTTGTVGEAPFG	QQKLDLGCACRWDGTTGTVGEAPFG	9.0	10.0	-	-	4110_2:172314925-172314925 G>A_QQKLDLGCACRWDGTTGTVGEAPFG	0.0
2:24297040-24297040 G>A	1.0	4234	NSCLC	-	-	-	-	SF3B6	uc002rev.3,p.R19W|ENST00000233468,p.R19W|NM_016047,p.R19W	retained_intron, protein_coding	uc002rev.3	nonsynonymous SNV	exon2	c.C55T	p.R19W	KRANIRLPPEVNRILYIRNLPYKIT	KRANIRLPPEVNWILYIRNLPYKIT	10.0	1.0	-	-	4234_2:24297040-24297040 G>A_KRANIRLPPEVNWILYIRNLPYKIT	0.0
2:141680548-141680548 G>A	0.0	3903	MELANOMA	-	-	-	1	LRP1B	NM_018557,p.S1102F|ENST00000389484,p.S1102F|ENST00000434794,p.S247F|uc002tvj.1,p.S1102F|uc010fnl.1,p.S284F	protein_coding, processed_transcript	uc010fnl.1	nonsynonymous SNV	exon6	c.C851T	p.S284F	GTIRLCDHKTKFSCWSTGRCINKAW	GTIRLCDHKTKFFCWSTGRCINKAW	1.0	3.0	-	-	3903_2:141680548-141680548 G>A_GTIRLCDHKTKFFCWSTGRCINKAW	0.0
13:100211702-100211702 C>T	1.0	3466	MELANOMA	-	-	-	-	TM9SF2	NM_004800,p.S613L|ENST00000376387,p.S613L|uc001voj.2,p.S613L|uc010afz.2,p.S448L	protein_coding, processed_transcript	uc010afz.2	nonsynonymous SNV	exon12	c.C1343T	p.S448L	VYFLIYAVHYFFSKLQITGTASTIL	VYFLIYAVHYFFLKLQITGTASTIL	10.0	9.0	-	-	3466_13:100211702-100211702 C>T_VYFLIYAVHYFFLKLQITGTASTIL	0.0
8:142367077-142367077 C>T	0.0	4316	COLORECTAL	-	-	-	-	GPR20	uc003ywf.3,p.G316E|uc022bby.1,p.G316E|ENST00000377741,p.G316E|NM_005293,p.G316E	protein_coding	uc022bby.1	nonsynonymous SNV	exon1	c.G947A	p.G316E	FQATVRGLFGQHGEREPSSGDVVSM	FQATVRGLFGQHEEREPSSGDVVSM	2.0	10.0	-	-	4316_8:142367077-142367077 C>T_FQATVRGLFGQHEEREPSSGDVVSM	0.0
4:20482373-20482373 G>A	0.0	3713	MELANOMA	-	-	-	-	SLIT2	uc003gps.1,p.D168N|ENST00000504154,p.D168N|ENST00000508824,p.D129N|NM_001289136,p.D168N|NM_001289135,p.D168N|uc003gpr.1,p.D168N|ENST00000503823,p.D168N|ENST00000273739,p.D168N|NM_004787,p.D168N|ENST00000503837,p.D168N	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon6	c.G502A	p.D168N	LQLDYNQISCIEDGAFRALRDLEVL	LQLDYNQISCIENGAFRALRDLEVL	3.0	5.0	-	-	3713_4:20482373-20482373 G>A_LQLDYNQISCIENGAFRALRDLEVL	0.0
3:132202230-132202230 G>C	0.0	4234	NSCLC	-	-	-	-	DNAJC13	uc003eor.3,p.L997F|NM_015268,p.L997F|ENST00000260818,p.L997F|ENST00000506813,p.L94F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eor.3	nonsynonymous SNV	exon28	c.G2991C	p.L997F	RSGPYGFHEMQELWTKGMLNAKTRC	RSGPYGFHEMQEFWTKGMLNAKTRC	8.0	3.0	-	-	4234_3:132202230-132202230 G>C_RSGPYGFHEMQEFWTKGMLNAKTRC	0.0
17:7700524-7700524 G>A	0.0	3903	MELANOMA	-	-	-	-	DNAH2	ENST00000572933,p.D2632N|ENST00000389173,p.D2632N|uc002giu.1,p.D2632N|NM_020877,p.D2632N	retained_intron, protein_coding, nonsense_mediated_decay	uc002giu.1	nonsynonymous SNV	exon50	c.G7894A	p.D2632N	SKVFQGMLRANKDFHDTKSSITRLW	SKVFQGMLRANKNFHDTKSSITRLW	4.0	9.0	-	-	3903_17:7700524-7700524 G>A_SKVFQGMLRANKNFHDTKSSITRLW	0.0
5:109974042-109974042 G>A	1.0	4000	MELANOMA	-	-	-	-	TMEM232	ENST00000511883,p.L120F|ENST00000429839,p.L120F|ENST00000515278,p.L120F|ENST00000455884,p.L120F|uc011cvh.2,p.L120F|NM_001039763,p.L120F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cvh.2	nonsynonymous SNV	exon5	c.C358T	p.L120F	CKGEIQDESLNMLYASLDHASFDYD	CKGEIQDESLNMFYASLDHASFDYD	5.0	8.0	-	-	4000_5:109974042-109974042 G>A_CKGEIQDESLNMFYASLDHASFDYD	0.0
17:7460168-7460168 G>C	0.0	3919	MELANOMA	-	-	-	-	TNFSF12,TNFSF12-TNFSF13	uc002ghi.1,p.Q149H|ENST00000557233,p.Q149H|ENST00000293825,p.Q149H|ENST00000293826,p.Q149H|NM_172089,p.Q149H|uc002ghg.3,p.Q149H|NM_003809,p.Q149H	protein_coding, processed_transcript, nonsense_mediated_decay	uc002ghi.1	nonsynonymous SNV	exon6	c.G447C	p.Q149H	RINSSSPLRYNRQIGEFIVTRAGLY	RINSSSPLRYNRHIGEFIVTRAGLY	8.0	3.0	-	-	3919_17:7460168-7460168 G>C_RINSSSPLRYNRHIGEFIVTRAGLY	0.0
12:57389777-57389777 G>A	0.0	4078	GASTRIC	-	-	-	-	GPR182	ENST00000300098,p.A262T|uc021qzf.1,p.A262T|uc001smk.3,p.A262T|NM_007264,p.A262T	protein_coding	uc021qzf.1	nonsynonymous SNV	exon1	c.G784A	p.A262T	QPKSRRHCLLLCAYVAVFVMCWLPY	QPKSRRHCLLLCTYVAVFVMCWLPY	1.0	10.0	-	-	4078_12:57389777-57389777 G>A_QPKSRRHCLLLCTYVAVFVMCWLPY	0.0
14:24845904-24845904 C>T	1.0	3713	MELANOMA	-	-	-	-	NFATC4	ENST00000556759,p.P356S|ENST00000422617,p.P809S|ENST00000555167,p.P356S|uc001wpc.3,p.P821S|ENST00000424781,p.P834S|uc010tol.2,p.P884S|uc010top.2,p.P853S|NM_001198966,p.P751S|uc010ton.2,p.P834S|ENST00000555590,p.P834S|NM_004554,p.P821S|ENST00000553708,p.P821S|ENST00000557451,p.P751S|uc010alt.3,p.P853S|ENST00000555802,p.P109S|uc010tok.2,p.P884S|ENST00000554344,p.P751S|ENST00000555453,p.P809S|uc010tos.2,p.P751S|NM_001288802,p.P809S|ENST00000553879,p.P751S|uc010alv.3,p.P809S|uc010tot.2,p.P809S|uc010tox.2,p.P751S|uc010tou.2,p.P751S|ENST00000413692,p.P884S|NM_001136022,p.P884S|uc010tom.2,p.P834S|uc010toz.2,p.P356S|ENST00000250373,p.P821S|ENST00000539237,p.P853S|uc001wpd.3,p.P356S|ENST00000556279,p.P853S|ENST00000555393,p.P109S|uc010tpb.2,p.P109S|uc010tpa.2,p.P109S	retained_intron, protein_coding, processed_transcript	uc010tpb.2	nonsynonymous SNV	exon4	c.C325T	p.P109S	APFRPPPLPASPPLEGPFPSQSDVH	APFRPPPLPASPSLEGPFPSQSDVH	4.0	4.0	-	-	3713_14:24845904-24845904 C>T_APFRPPPLPASPSLEGPFPSQSDVH	0.0
12:7173169-7173169 C>T	1.0	3466	MELANOMA	-	-	-	-	C1S	uc009zfr.3,p.P89S|NM_001734,p.P256S|uc001qsj.3,p.P256S|ENST00000402681,p.P89S|ENST00000328916,p.P256S|ENST00000542978,p.P89S|uc001qsk.3,p.P256S|uc001qsl.3,p.P256S|NM_201442,p.P256S|ENST00000360817,p.P256S|ENST00000406697,p.P256S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zfr.3	nonsynonymous SNV	exon6	c.C265T	p.P89S	DRQFGPYCGHGFPGPLNIETKSNAL	DRQFGPYCGHGFSGPLNIETKSNAL	10.0	4.0	-	-	3466_12:7173169-7173169 C>T_DRQFGPYCGHGFSGPLNIETKSNAL	0.0
5:71627141-71627141 T>A	1.0	3713	MELANOMA	-	-	-	-	PTCD2	ENST00000543322,p.F136Y|uc003kcb.3,p.F136Y|ENST00000308077,p.F136Y|NM_024754,p.F136Y|ENST00000515198,p.F136Y|ENST00000380639,p.F136Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc003kcb.3	nonsynonymous SNV	exon4	c.T407A	p.F136Y	NFTLGEYKFGPLFVRLCYELDLEES	NFTLGEYKFGPLYVRLCYELDLEES	4.0	7.0	-	-	3713_5:71627141-71627141 T>A_NFTLGEYKFGPLYVRLCYELDLEES	0.0
22:38122090-38122090 C>T	0.0	2369	MELANOMA	-	-	-	-	TRIOBP	uc003atq.1,p.S1176F|uc003ats.1,p.S1004F|NM_001039141,p.S1176F|uc003atu.3,p.S1004F|ENST00000406386,p.S1176F|uc003atr.3,p.S1176F	retained_intron, protein_coding, nonsense_mediated_decay	uc003atu.3	nonsynonymous SNV	exon5	c.C3011T	p.S1004F	VCIGHRDAPSFSSPPRQAPEPSLFF	VCIGHRDAPSFSFPPRQAPEPSLFF	8.0	8.0	-	-	2369_22:38122090-38122090 C>T_VCIGHRDAPSFSFPPRQAPEPSLFF	0.0
1:196643034-196643034 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	CFH	uc009wyx.3,p.L98I|NM_000186,p.L98I|uc001gtj.4,p.L98I|ENST00000439155,p.L98I|uc009wyw.3,p.L98I|ENST00000367429,p.L98I|uc001gti.4,p.L98I|NM_001014975,p.L98I|ENST00000359637,p.L98I	retained_intron, protein_coding, ambiguous_orf	uc009wyx.3	nonsynonymous SNV	exon3	c.C292A	p.L98I	GHPGDTPFGTFTLTGGNVFEYGVKA	GHPGDTPFGTFTITGGNVFEYGVKA	8.0	4.0	-	-	4258_1:196643034-196643034 C>A_GHPGDTPFGTFTITGGNVFEYGVKA	0.0
4:66280083-66280083 A>C	0.0	4258	ENDOMETRIAL	-	-	-	-	EPHA5	uc011cai.2,p.Y536D|uc003hcz.3,p.Y536D|NM_004439,p.Y536D|NM_001281767,p.Y536D|NM_001281765,p.Y536D|NM_182472,p.Y536D|ENST00000511294,p.Y536D|uc011cah.2,p.Y536D|ENST00000354839,p.Y536D|uc003hcy.3,p.Y536D|NM_001281766,p.Y536D|ENST00000432638,p.Y372D|ENST00000273854,p.Y536D|uc003hda.2,p.Y536D|uc003hcx.3,p.Y467D	protein_coding	uc011cai.2	nonsynonymous SNV	exon7	c.T1606G	p.Y536D	TITAEGLKPASVYVFQIRARTAAGY	TITAEGLKPASVDVFQIRARTAAGY	1.0	7.0	-	-	4258_4:66280083-66280083 A>C_TITAEGLKPASVDVFQIRARTAAGY	0.0
15:99482538-99482538 C>T	1.0	3713	MELANOMA	-	-	-	-	IGF1R	uc002bul.3,p.L1136F|ENST00000558762,p.L1135F|NM_000875,p.L1136F|NM_001291858,p.L1135F|uc010bon.3,p.L1135F|ENST00000268035,p.L1136F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bon.3	nonsynonymous SNV	exon18	c.C3403T	p.L1135F	AYLNANKFVHRDLAARNCMVAEDFT	AYLNANKFVHRDFAARNCMVAEDFT	8.0	6.0	-	-	3713_15:99482538-99482538 C>T_AYLNANKFVHRDFAARNCMVAEDFT	0.0
10:32740760-32740760 C>T	0.0	4345	COLORECTAL	-	-	-	-	CCDC7	ENST00000362006,p.R64W|uc001iwj.3,p.R64W|ENST00000545067,p.R64W|ENST00000476558,p.R64W|uc001iwk.3,p.R64W|ENST00000277657,p.R64W|uc009xlx.1,p.R64W|NM_145023,p.R64W|ENST00000535327,p.R64W|NM_001026383,p.R64W|ENST00000537047,p.R64W|ENST00000539197,p.R64W	protein_coding, processed_transcript, nonsense_mediated_decay	uc009xlx.1	nonsynonymous SNV	exon1	c.C190T	p.R64W	VLRSPPTGESILRYALPIPSSKTKN	VLRSPPTGESILWYALPIPSSKTKN	5.0	10.0	-	-	4345_10:32740760-32740760 C>T_VLRSPPTGESILWYALPIPSSKTKN	0.0
11:102401365-102401365 C>T	0.0	4189	MELANOMA	-	-	-	-	MMP7	uc009yxd.3,p.E23K|ENST00000260227,p.E23K|uc001phb.3,p.E23K|uc010rus.1,p.E23K|NM_002423,p.E23K	retained_intron, protein_coding	uc010rus.1	nonsynonymous SNV	exon1	c.G67A	p.E23K	LLPGSLALPLPQEAGGMSELQWEQA	LLPGSLALPLPQKAGGMSELQWEQA	6.0	9.0	-	-	4189_11:102401365-102401365 C>T_LLPGSLALPLPQKAGGMSELQWEQA	0.0
16:10996020-10996020 G>A	1.0	3919	MELANOMA	-	-	-	1	CIITA	NM_001286402,p.E204K|uc010bup.1,p.E203K|uc002daj.4,p.E204K|uc002dai.4,p.E203K|uc002dag.2,p.E203K|ENST00000324288,p.E203K|NM_000246,p.E203K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bup.1	nonsynonymous SNV	exon7	c.G607A	p.E203K	FNQEPASGQMRLEKTDQIPMPFSSS	FNQEPASGQMRLKKTDQIPMPFSSS	10.0	4.0	-	-	3919_16:10996020-10996020 G>A_FNQEPASGQMRLKKTDQIPMPFSSS	0.0
19:4323619-4323619 C>G	0.0	4258	ENDOMETRIAL	-	-	-	-	FSD1	NM_024333,p.S490R|uc002lzy.2,p.S490R|uc002maa.2,p.S303R|ENST00000221856,p.S490R	retained_intron, protein_coding, processed_transcript	uc002maa.2	nonsynonymous SNV	exon7	c.C909G	p.S303R	VRCLQKRGSATSSSNTSLT	VRCLQKRGSATSRSNTSLT	3.0	8.0	-	-	4258_19:4323619-4323619 C>G_VRCLQKRGSATSRSNTSLT	0.0
9:139350568-139350568 T>G	1.0	4284	COLORECTAL	-	-	-	-	SEC16A	ENST00000313050,p.E1867D|uc004chv.4,p.E1257D|uc004chx.3,p.E1867D|uc004chw.3,p.E1867D|NM_014866,p.E1867D|NM_001276418,p.E1867D|ENST00000290037,p.E1689D|ENST00000277537,p.E261D|ENST00000371706,p.E1689D|uc010nbn.3,p.E1867D|ENST00000453963,p.E589D|ENST00000431893,p.E1689D|uc004chu.3,p.E52D	protein_coding, processed_transcript	uc010nbn.3	nonsynonymous SNV	exon18	c.A5601C	p.E1867D	LRLFDPQLKEKPEEESLAAPTWLVH	LRLFDPQLKEKPDEESLAAPTWLVH	8.0	6.0	-	-	4284_9:139350568-139350568 T>G_LRLFDPQLKEKPDEESLAAPTWLVH	0.0
X:105279269-105279269 A>G	1.0	4278	COLORECTAL	-	-	-	-	SERPINA7	uc010npe.2,p.Y244H|ENST00000372563,p.Y244H|ENST00000327674,p.Y244H|NM_000354,p.Y244H|uc010npd.3,p.Y244H|uc004eme.2,p.Y244H	protein_coding, processed_transcript	uc010npe.2	nonsynonymous SNV	exon3	c.T730C	p.Y244H	TVQVPMMHQMEQYYHLVDMELNCTV	TVQVPMMHQMEQHYHLVDMELNCTV	5.0	9.0	-	-	4278_X:105279269-105279269 A>G_TVQVPMMHQMEQHYHLVDMELNCTV	0.0
11:124013167-124013167 T>C	1.0	2369	MELANOMA	-	-	-	-	VWA5A	uc001pzt.3,p.L681P|ENST00000392748,p.L681P|NM_014622,p.L681P|ENST00000456829,p.L681P|NM_001130142,p.L681P|uc001pzu.3,p.L681P	retained_intron, protein_coding	uc001pzu.3	nonsynonymous SNV	exon17	c.T2042C	p.L681P	KDQHSPGFGENHLVQLIYHQNANGS	KDQHSPGFGENHPVQLIYHQNANGS	6.0	9.0	-	-	2369_11:124013167-124013167 T>C_KDQHSPGFGENHPVQLIYHQNANGS	0.0
10:8007211-8007211 C>T	1.0	3713	MELANOMA	-	-	-	-	TAF3	ENST00000344293,p.L580F|NM_031923,p.L580F|uc010qbd.3,p.L580F	protein_coding	uc010qbd.3	nonsynonymous SNV	exon3	c.C1738T	p.L580F	TGRETKYPWKEFLKEEEADPYKFKI	TGRETKYPWKEFFKEEEADPYKFKI	4.0	5.0	-	-	3713_10:8007211-8007211 C>T_TGRETKYPWKEFFKEEEADPYKFKI	0.0
17:30348769-30348769 C>T	0.0	2591	MELANOMA	-	-	-	-	LRRC37B	ENST00000543378,p.L120F|ENST00000394713,p.L202F|ENST00000327564,p.L229F|uc031qzu.1,p.L120F|NM_052888,p.L202F|ENST00000578674,p.L214F|uc031qzs.1,p.L120F|uc010wbx.2,p.L120F|ENST00000584368,p.L214F|ENST00000341671,p.L202F|uc010csu.3,p.L202F|uc002hgu.3,p.L202F|ENST00000579206,p.L120F|ENST00000583342,p.L184F|uc031qzt.1,p.L120F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qzu.1	nonsynonymous SNV	exon1	c.C358T	p.L120F	KNLKKDLAERWSLPEIVGIPHQLSK	KNLKKDLAERWSFPEIVGIPHQLSK	6.0	3.0	-	-	2591_17:30348769-30348769 C>T_KNLKKDLAERWSFPEIVGIPHQLSK	0.0
13:78475284-78475284 G>A	0.0	4155	MELANOMA	-	-	-	-	EDNRB	NM_000115,p.A287V|ENST00000446573,p.A287V|ENST00000377211,p.A377V|NM_003991,p.A287V|uc010aez.1,p.A287V|uc001vko.2,p.A287V|uc001vkp.1,p.A377V|ENST00000334286,p.A287V|uc001vkq.1,p.A287V|NM_001122659,p.A287V|NM_001201397,p.A377V	protein_coding, processed_transcript	uc010aez.1	nonsynonymous SNV	exon4	c.C860T	p.A287V	WWLFSFYFCLPLAITAFFYTLMTCE	WWLFSFYFCLPLVITAFFYTLMTCE	8.0	4.0	CD8	-	4155_13:78475284-78475284 G>A_WWLFSFYFCLPLVITAFFYTLMTCE	2.0
14:24458197-24458197 G>A	1.0	4213	COLORECTAL	-	-	-	-	DHRS4L2	uc001wli.4,p.R14Q|ENST00000558753,p.R14Q|ENST00000545240,p.R14Q|ENST00000559411,p.R14Q|ENST00000537912,p.R14Q|ENST00000335125,p.R14Q|NM_198083,p.R14Q|ENST00000397071,p.R14Q	retained_intron, protein_coding	uc001wli.4	nonsynonymous SNV	exon1	c.G41A	p.R14Q	QMARLLGLCAWARKSVRMASSRMTR	QMARLLGLCAWAQKSVRMASSRMTR	8.0	10.0	-	-	4213_14:24458197-24458197 G>A_QMARLLGLCAWAQKSVRMASSRMTR	0.0
X:155003925-155003925 G>A	1.0	3879	MELANOMA	-	-	-	-	SPRY3	uc004fnq.1,p.G131E|ENST00000302805,p.G131E|uc022cio.1,p.G131E|NM_005840,p.G131E	protein_coding	uc022cio.1	nonsynonymous SNV	exon1	c.G392A	p.G131E	AGVHPKADGALKGEAEQSAGHPSEH	AGVHPKADGALKEEAEQSAGHPSEH	4.0	7.0	-	-	3879_X:155003925-155003925 G>A_AGVHPKADGALKEEAEQSAGHPSEH	0.0
20:44639917-44639925 ACGACACCG>-	0.0	4252	COLORECTAL	-	-	-	-	MMP9	ENST00000372330,p.262_265del|NM_004994,p.262_265del|uc002xqz.3,p.262_265del	protein_coding	uc002xqz.3	nonframeshift deletion	exon5	c.785_793del	p.262_265del	SDGLPWCSTTANYDTDDRFGFCPSE	SDGLPWCSTTANYDRFGFCPSERLY	9.0	6.0	-	-	4252_20:44639917-44639925 ACGACACCG>-_SDGLPWCSTTANYDRFGFCPSERLY	0.0
15:40241380-40241380 C>T	1.0	3466	MELANOMA	-	-	-	-	EIF2AK4	ENST00000263791,p.P142S|uc001zkl.3,p.P142S|ENST00000559624,p.P142S|ENST00000382727,p.P142S|NM_001013703,p.P142S|uc001zkm.1,p.P142S	retained_intron, protein_coding, processed_transcript, TEC	uc001zkm.1	nonsynonymous SNV	exon4	c.C424T	p.P142S	VQSFLSEHNKPPPKSFHEEMLERRA	VQSFLSEHNKPPSKSFHEEMLERRA	8.0	2.0	-	-	3466_15:40241380-40241380 C>T_VQSFLSEHNKPPSKSFHEEMLERRA	0.0
15:74636306-74636306 C>T	0.0	4298	COLORECTAL	-	-	-	-	CYP11A1	ENST00000566674,p.R60H|uc010bjm.1,p.R60H|uc002axt.2,p.R218H|NM_001099773,p.R60H|ENST00000358632,p.R60H|uc002axs.2,p.R60H|NM_000781,p.R218H|ENST00000450547,p.R60H|ENST00000435365,p.R218H|ENST00000268053,p.R218H|ENST00000419019,p.R60H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bjm.1	nonsynonymous SNV	exon3	c.G179A	p.R60H	AFESITNVIFGERQGMLEEVVNPEA	AFESITNVIFGEHQGMLEEVVNPEA	3.0	6.0	-	-	4298_15:74636306-74636306 C>T_AFESITNVIFGEHQGMLEEVVNPEA	0.0
4:52861143-52861143 G>A	0.0	4235	COLORECTAL	-	-	-	-	LRRC66	uc003gzi.3,p.A682V|NM_001024611,p.A682V|ENST00000343457,p.A682V	protein_coding	uc003gzi.3	nonsynonymous SNV	exon4	c.C2045T	p.A682V	PPRWDSGLDVTPANKEPVQKSTPSD	PPRWDSGLDVTPVNKEPVQKSTPSD	4.0	5.0	-	-	4235_4:52861143-52861143 G>A_PPRWDSGLDVTPVNKEPVQKSTPSD	0.0
17:48243435-48243435 G>A	0.0	4316	COLORECTAL	-	-	-	-	SGCA	ENST00000514934,p.V12M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000514934	nonsynonymous SNV	exon1	c.G34A	p.V12M	MAETLFWTPLLVGKLGPCSAGRPR	MAETLFWTPLLMGKLGPCSAGRPR	2.0	7.0	-	-	4316_17:48243435-48243435 G>A_MAETLFWTPLLMGKLGPCSAGRPR	0.0
13:95112365-95112365 C>T	0.0	4346	COLORECTAL	-	-	-	-	DCT	uc001vlv.4,p.A387T|NM_001922,p.A387T|ENST00000377028,p.A387T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001vlv.4	nonsynonymous SNV	exon6	c.G1159A	p.A387T	FLNGTNALPHSAANDPIFVVLHSFT	FLNGTNALPHSATNDPIFVVLHSFT	2.0	1.0	-	-	4346_13:95112365-95112365 C>T_FLNGTNALPHSATNDPIFVVLHSFT	0.0
7:5540263-5540263 G>A	0.0	4158	COLORECTAL	-	-	-	-	FBXL18	ENST00000382368,p.T546M|uc003son.4,p.T546M|NM_024963,p.T546M|ENST00000415009,p.T546M|uc003soo.2,p.T546M|ENST00000453700,p.T546M	protein_coding, nonsense_mediated_decay	uc003soo.2	nonsynonymous SNV	exon3	c.C1637T	p.T546M	RHLTLAQLPSVLTGSGLVNIGLQCQ	RHLTLAQLPSVLMGSGLVNIGLQCQ	7.0	4.0	-	-	4158_7:5540263-5540263 G>A_RHLTLAQLPSVLMGSGLVNIGLQCQ	0.0
5:140740222-140740222 G>C	0.0	4240	BREAST	-	-	-	-	PCDHGB2	NM_032096,p.D174H|uc011dar.2,p.D174H|NM_018923,p.D174H|uc003ljs.2,p.D174H|ENST00000522605,p.D174H	protein_coding	uc011dar.2	nonsynonymous SNV	exon1	c.G520C	p.D174H	VGPNSLQRYHLNDNEYFDLAEKQTP	VGPNSLQRYHLNHNEYFDLAEKQTP	5.0	9.0	-	-	4240_5:140740222-140740222 G>C_VGPNSLQRYHLNHNEYFDLAEKQTP	0.0
4:108824510-108824510 C>T	1.0	4252	COLORECTAL	-	-	-	-	SGMS2	NM_152621,p.T232M|uc003hyn.3,p.T232M|NM_001136257,p.T232M|NM_001136258,p.T232M|ENST00000394686,p.T232M|ENST00000359079,p.T232M|uc003hyo.3,p.T232M|ENST00000503862,p.T59M|ENST00000394684,p.T232M|uc003hyl.4,p.T232M	protein_coding, processed_transcript	uc003hyo.3	nonsynonymous SNV	exon4	c.C695T	p.T232M	LCGDFLFSGHTVTLTLTYLFIKEYS	LCGDFLFSGHTVMLTLTYLFIKEYS	6.0	10.0	-	-	4252_4:108824510-108824510 C>T_LCGDFLFSGHTVMLTLTYLFIKEYS	0.0
14:72128139-72128139 T>C	1.0	4110	BILE DUCT	-	-	-	-	SIPA1L1	uc001xmv.3,p.V737A|uc001xmt.3,p.V737A|ENST00000537413,p.V212A|ENST00000381232,p.V737A|uc001xmu.3,p.V737A|ENST00000555818,p.V737A|NM_001284246,p.V737A|NM_001284247,p.V737A|NM_001284245,p.V737A|uc001xms.3,p.V737A|uc010ttm.2,p.V212A|NM_015556,p.V737A|ENST00000358550,p.V737A	retained_intron, protein_coding, processed_transcript	uc010ttm.2	nonsynonymous SNV	exon6	c.T635C	p.V212A	PKNIRSHFQHVFVIVRVHNPCSDSV	PKNIRSHFQHVFAIVRVHNPCSDSV	7.0	9.0	-	-	4110_14:72128139-72128139 T>C_PKNIRSHFQHVFAIVRVHNPCSDSV	0.0
14:105414996-105414996 G>C	1.0	4316	COLORECTAL	-	-	-	-	AHNAK2	uc001ypx.2,p.D2164E|ENST00000333244,p.D2264E|NM_138420,p.D2264E|uc010axc.1,p.D2264E	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.C6792G	p.D2264E	KGPEIDIKGPKLDLKDPKVEVTAPD	KGPEIDIKGPKLELKDPKVEVTAPD	10.0	9.0	-	-	4316_14:105414996-105414996 G>C_KGPEIDIKGPKLELKDPKVEVTAPD	0.0
2:131414737-131414737 A>G	0.0	4326	BREAST	-	rs4531942	-	-	POTEJ	NM_001277083,p.M802V|ENST00000409602,p.M802V|uc021vor.2,p.M802V	protein_coding	uc021vor.2	nonsynonymous SNV	exon15	c.A2404G	p.M802V	FNTPAMYVAIQAMLSLYTSGRTTGI	FNTPAMYVAIQAVLSLYTSGRTTGI	9.0	4.0	-	-	4326_2:131414737-131414737 A>G_FNTPAMYVAIQAVLSLYTSGRTTGI	0.0
17:7758773-7758773 C>T	0.0	2556	MELANOMA	-	-	-	-	TMEM88	uc002giy.3,p.S74F|NM_203411,p.S74F|ENST00000301599,p.S74F	protein_coding	uc002giy.3	nonsynonymous SNV	exon2	c.C221T	p.S74F	GFGFLCHSQFLRSQAPPCTAHLRDP	GFGFLCHSQFLRFQAPPCTAHLRDP	3.0	7.0	-	-	2556_17:7758773-7758773 C>T_GFGFLCHSQFLRFQAPPCTAHLRDP	0.0
7:98449098-98449098 C>T	0.0	4266	COLORECTAL	-	-	ID=COSM602952;OCCURENCE=1(lung)	-	TMEM130	uc011kiq.2,p.E299K|uc003upn.3,p.E216K|uc003upo.3,p.E318K|ENST00000345589,p.E216K|uc011kir.2,p.E318K|ENST00000450876,p.E234K|NM_001134451,p.E216K|ENST00000416379,p.E318K|ENST00000339375,p.E318K|NM_001134450,p.E318K|NM_152913,p.E318K|ENST00000546258,p.E299K	protein_coding, processed_transcript	uc011kir.2	nonsynonymous SNV	exon6	c.G952A	p.E318K	RDPGDYCFSIRAENIISKTHQYHKI	RDPGDYCFSIRAKNIISKTHQYHKI	3.0	9.0	-	-	4266_7:98449098-98449098 C>T_RDPGDYCFSIRAKNIISKTHQYHKI	0.0
6:107390917-107390917 G>A	1.0	4298	COLORECTAL	-	-	-	-	BEND3	ENST00000429433,p.P493L|uc003prs.2,p.P493L|NM_001080450,p.P493L|ENST00000369042,p.P493L	protein_coding	uc003prs.2	nonsynonymous SNV	exon5	c.C1478T	p.P493L	EGLGLDAGSEGDPPRDDCYDSSSLP	EGLGLDAGSEGDLPRDDCYDSSSLP	5.0	10.0	-	-	4298_6:107390917-107390917 G>A_EGLGLDAGSEGDLPRDDCYDSSSLP	0.0
16:25704453-25704453 A>G	0.0	4078	GASTRIC	-	-	-	-	HS3ST4	uc002dof.3,p.K239E|NM_006040,p.K239E|ENST00000331351,p.K239E	protein_coding, processed_transcript	uc002dof.3	nonsynonymous SNV	exon1	c.A715G	p.K239E	GVEPHFFDRNYEKGLEWYRNVMPKT	GVEPHFFDRNYEEGLEWYRNVMPKT	1.0	6.0	-	-	4078_16:25704453-25704453 A>G_GVEPHFFDRNYEEGLEWYRNVMPKT	0.0
17:18023807-18023807 G>A	0.0	4160	COLORECTAL	-	-	-	-	MYO15A	uc021trl.1,p.V565M|ENST00000205890,p.V565M|NM_016239,p.V565M|uc021trm.1,p.V565M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021trm.1	nonsynonymous SNV	exon1	c.G1693A	p.V565M	RGLGFGPEFGRPVPRPATSLARFLK	RGLGFGPEFGRPMPRPATSLARFLK	2.0	5.0	-	-	4160_17:18023807-18023807 G>A_RGLGFGPEFGRPMPRPATSLARFLK	0.0
14:44974495-44974495 C>T	0.0	3795	MELANOMA	-	-	-	-	FSCB	NM_032135,p.G566R|uc001wvn.3,p.G566R|ENST00000340446,p.G566R	protein_coding	uc001wvn.3	nonsynonymous SNV	exon1	c.G1696A	p.G566R	EAPAEVQSPSAKGVSIEEAPLELQP	EAPAEVQSPSAKRVSIEEAPLELQP	1.0	8.0	-	-	3795_14:44974495-44974495 C>T_EAPAEVQSPSAKRVSIEEAPLELQP	0.0
8:24771437-24771437 C>T	0.0	4301	MELANOMA	-	-	-	-	NEFM	ENST00000221166,p.S44L|uc011lac.1,p.S44L|uc003xed.4,p.S44L|ENST00000518131,p.S44L|NM_005382,p.S44L|ENST00000437366,p.S44L	protein_coding, processed_transcript	uc011lac.1	nonsynonymous SNV	exon1	c.C131T	p.S44L	SSGFRSQSWSRGSPSTVSSSYKRSM	SSGFRSQSWSRGLPSTVSSSYKRSM	3.0	4.0	-	-	4301_8:24771437-24771437 C>T_SSGFRSQSWSRGLPSTVSSSYKRSM	0.0
11:99715643-99715643 G>T	0.0	4081	COLORECTAL	-	-	-	-	CNTN5	ENST00000524871,p.D113Y|ENST00000527185,p.D113Y|NM_014361,p.D113Y|ENST00000528682,p.D113Y|ENST00000418526,p.D39Y|NM_175566,p.D39Y|ENST00000279463,p.D113Y|uc001pfz.3,p.D113Y|NM_001243270,p.D113Y|uc021qpc.1,p.D39Y|uc021qpb.1,p.D113Y|uc001pga.3,p.D113Y|uc009ywv.2,p.D113Y|NM_001243271,p.D113Y	retained_intron, protein_coding, processed_transcript	uc021qpc.1	nonsynonymous SNV	exon2	c.G115T	p.D39Y	FVQEPDDIIFPTDSDEKKVALNCEV	FVQEPDDIIFPTYSDEKKVALNCEV	1.0	3.0	-	-	4081_11:99715643-99715643 G>T_FVQEPDDIIFPTYSDEKKVALNCEV	0.0
11:121416033-121416033 C>T	0.0	2556	MELANOMA	-	-	-	-	SORL1	ENST00000260197,p.T649I|uc001pxx.3,p.T649I|NM_003105,p.T649I	retained_intron, protein_coding, processed_transcript	uc001pxx.3	nonsynonymous SNV	exon14	c.C1946T	p.T649I	DERGNECLLGHKTVFKRRTPHATCF	DERGNECLLGHKIVFKRRTPHATCF	5.0	4.0	-	-	2556_11:121416033-121416033 C>T_DERGNECLLGHKIVFKRRTPHATCF	0.0
20:25203614-25203614 G>C	1.0	4240	BREAST	-	-	-	-	ENTPD6	uc002wuo.2,p.D148H|uc010zsz.1,p.D178H|uc002wul.2,p.D395H|uc002wuj.2,p.D396H|ENST00000360031,p.D395H|uc010ztc.1,p.D368H|ENST00000376652,p.D396H|NM_001247,p.D396H|uc002wum.2,p.D379H|uc002wuk.2,p.D395H|uc010ztb.1,p.D368H|uc010ztd.1,p.D144H|ENST00000354989,p.D379H|ENST00000433259,p.D362H|uc010zta.1,p.D396H|NM_001114089,p.D379H	protein_coding, processed_transcript	uc010ztd.1	nonsynonymous SNV	exon8	c.G430C	p.D144H	YYYDLAAGVGLIDAEKGGSLVVGDF	YYYDLAAGVGLIHAEKGGSLVVGDF	10.0	10.0	-	-	4240_20:25203614-25203614 G>C_YYYDLAAGVGLIHAEKGGSLVVGDF	0.0
18:54424310-54424310 C>T	0.0	2591	MELANOMA	-	-	-	-	WDR7	uc002lgk.1,p.P829L|ENST00000254442,p.P829L|NM_015285,p.P829L|ENST00000585824,p.P231L|uc002lgl.1,p.P829L|NM_052834,p.P829L|ENST00000357574,p.P829L	retained_intron, protein_coding, nonsense_mediated_decay	uc002lgl.1	nonsynonymous SNV	exon15	c.C2486T	p.P829L	DEVCLDRLGMLKPHCTVSFGLLSRG	DEVCLDRLGMLKLHCTVSFGLLSRG	4.0	9.0	-	-	2591_18:54424310-54424310 C>T_DEVCLDRLGMLKLHCTVSFGLLSRG	0.0
19:21720498-21720498 G>T	1.0	4245	COLORECTAL	-	-	-	2	ZNF429	NM_001001415,p.R548L|ENST00000358491,p.R548L|uc002nqd.1,p.R548L	protein_coding, processed_transcript	uc002nqd.1	nonsynonymous SNV	exon4	c.G1643T	p.R548L	PYKCEECGKAFNRSSRLTQHKKIHT	PYKCEECGKAFNLSSRLTQHKKIHT	7.0	4.0	-	-	4245_19:21720498-21720498 G>T_PYKCEECGKAFNLSSRLTQHKKIHT	0.0
3:52939286-52939286 C>A	1.0	4160	COLORECTAL	-	-	-	-	SFMBT1	uc010hmr.3,p.D727Y|ENST00000296295,p.D780Y	retained_intron, protein_coding, processed_transcript	uc010hmr.3	nonsynonymous SNV	exon17	c.G2179T	p.D727Y	DDENKPPSPKEIDGQALLLLTLPTV	DDENKPPSPKEIYGQALLLLTLPTV	7.0	1.0	-	-	4160_3:52939286-52939286 C>A_DDENKPPSPKEIYGQALLLLTLPTV	0.0
20:8689378-8689378 C>T	1.0	4000	MELANOMA	-	-	ID=COSM1029318,COSM1029319;OCCURENCE=1(endometrium)	-	PLCB1	uc002wnc.1,p.S309L|ENST00000378641,p.S410L|uc002wna.4,p.S410L|NM_015192,p.S410L|uc002wnb.4,p.S410L|uc010zrb.1,p.S309L|NM_182734,p.S410L|ENST00000338037,p.S410L|ENST00000378637,p.S410L	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zrb.1	nonsynonymous SNV	exon12	c.C926T	p.S309L	CAFKTSPFPILLSFENHVDSPKQQA	CAFKTSPFPILLLFENHVDSPKQQA	5.0	9.0	-	-	4000_20:8689378-8689378 C>T_CAFKTSPFPILLLFENHVDSPKQQA	0.0
1:185267310-185267310 T>A	1.0	4287	COLORECTAL	-	-	-	-	IVNS1ABP	uc001grj.3,p.R256W|ENST00000367498,p.R596W|uc009wyj.3,p.R378W|ENST00000392007,p.R378W|NM_006469,p.R596W|uc001gri.3,p.R256W|uc001grl.3,p.R596W	retained_intron, protein_coding, processed_transcript	uc009wyj.3	nonsynonymous SNV	exon15	c.A1132T	p.R378W	NEWKMMGNMTSPRSNAGIATVGNTI	NEWKMMGNMTSPWSNAGIATVGNTI	9.0	6.0	-	-	4287_1:185267310-185267310 T>A_NEWKMMGNMTSPWSNAGIATVGNTI	0.0
12:112674805-112674805 C>A	1.0	4258	ENDOMETRIAL	-	-	-	-	HECTD4	NM_001109662,p.Q1662H|ENST00000377560,p.Q1624H|ENST00000430131,p.Q1374H|ENST00000550722,p.Q1650H|uc021reb.1,p.Q1662H	retained_intron, protein_coding, processed_transcript	uc021reb.1	nonsynonymous SNV	exon35	c.G4986T	p.Q1662H	NHLARATECCGNQAAGNDALQDVLS	NHLARATECCGNHAAGNDALQDVLS	8.0	9.0	-	-	4258_12:112674805-112674805 C>A_NHLARATECCGNHAAGNDALQDVLS	0.0
1:244574626-244574626 G>C	1.0	4037	NSCLC	-	-	-	-	ADSS	ENST00000366535,p.N427K|NM_001126,p.N427K|uc001iaj.3,p.N427K	protein_coding, processed_transcript	uc001iaj.3	nonsynonymous SNV	exon12	c.C1281G	p.N427K	ARAFKELPVNAQNYVRFIEDELQIP	ARAFKELPVNAQKYVRFIEDELQIP	9.0	10.0	-	-	4037_1:244574626-244574626 G>C_ARAFKELPVNAQKYVRFIEDELQIP	0.0
1:227947151-227947151 C>T	1.0	3713	MELANOMA	-	-	-	-	SNAP47	ENST00000366760,p.S121F|ENST00000366759,p.S363F|uc001hra.2,p.S121F|uc001hrf.2,p.S363F|uc001hre.3,p.S121F|ENST00000315781,p.S363F|NM_053052,p.S363F|uc001hrd.3,p.S363F	protein_coding, processed_transcript	uc001hrf.2	nonsynonymous SNV	exon3	c.C1088T	p.S363F	EDALVLRSARTSSPAEKSCSVWHAA	EDALVLRSARTSFPAEKSCSVWHAA	7.0	5.0	-	-	3713_1:227947151-227947151 C>T_EDALVLRSARTSFPAEKSCSVWHAA	0.0
6:32411073-32411073 T>C	1.0	3713	MELANOMA	-	-	-	-	HLA-DRA	uc003obh.3,p.L147P|ENST00000374982,p.L122P|NM_019111,p.L147P|ENST00000395388,p.L147P|uc003obi.3,p.L122P	protein_coding, processed_transcript	uc003obi.3	nonsynonymous SNV	exon3	c.T365C	p.L122P	DKFTPPVVNVTWLRNGKPVTTGVSE	DKFTPPVVNVTWPRNGKPVTTGVSE	10.0	3.0	-	-	3713_6:32411073-32411073 T>C_DKFTPPVVNVTWPRNGKPVTTGVSE	0.0
2:72362460-72362460 C>T	0.0	4316	COLORECTAL	-	-	-	-	CYP26B1	ENST00000546307,p.S98N|uc010yrb.2,p.S98N|NM_001277742,p.S98N|ENST00000474509,p.S98N|ENST00000461519,p.S156N|ENST00000001146,p.S173N|uc010yra.1,p.S156N|NM_019885,p.S173N|uc002sih.2,p.S173N	protein_coding	uc010yrb.2	nonsynonymous SNV	exon2	c.G293A	p.S98N	IQLVIQDTLRAWSSHPEAINVYQEA	IQLVIQDTLRAWNSHPEAINVYQEA	4.0	9.0	-	-	4316_2:72362460-72362460 C>T_IQLVIQDTLRAWNSHPEAINVYQEA	0.0
14:42360614-42360614 G>A	0.0	4095	COLORECTAL	-	-	-	-	LRFN5	uc001wvm.3,p.R516H|ENST00000298119,p.R516H|NM_152447,p.R516H	protein_coding, processed_transcript	uc001wvm.3	nonsynonymous SNV	exon4	c.G1547A	p.R516H	GCIQFTTEQDYVRCHFMQSQFLGGT	GCIQFTTEQDYVHCHFMQSQFLGGT	4.0	9.0	-	-	4095_14:42360614-42360614 G>A_GCIQFTTEQDYVHCHFMQSQFLGGT	0.0
6:75865979-75865979 T>C	0.0	2591	MELANOMA	-	-	-	-	COL12A1	ENST00000483888,p.T1082A|uc021zbv.1,p.T1082A|ENST00000416123,p.T1082A|NM_004370,p.T1082A|ENST00000322507,p.T1082A|uc003phs.3,p.T1082A	retained_intron, protein_coding, processed_transcript	uc021zbv.1	nonsynonymous SNV	exon14	c.A3244G	p.T1082A	KMGEGKLRQGSGTTASRFKSPRNLK	KMGEGKLRQGSGATASRFKSPRNLK	2.0	7.0	-	-	2591_6:75865979-75865979 T>C_KMGEGKLRQGSGATASRFKSPRNLK	0.0
4:114199081-114199081 C>G	0.0	4186	BREAST	-	-	-	-	ANK2	NM_020977,p.S591C|ENST00000394537,p.S591C|uc003ibf.4,p.S591C|NM_001127493,p.S570C|ENST00000503271,p.S570C|uc003ibc.2,p.S567C|ENST00000504454,p.S606C|NM_001148,p.S591C|ENST00000264366,p.S591C|ENST00000357077,p.S591C|uc011cgb.1,p.S606C|uc003ibd.4,p.S570C|ENST00000506722,p.S570C|uc003ibe.4,p.S591C	retained_intron, protein_coding, processed_transcript	uc011cgb.1	nonsynonymous SNV	exon17	c.C1817G	p.S606C	AKLLLQRRAAADSAGKNGLTPLHVA	AKLLLQRRAAADCAGKNGLTPLHVA	2.0	7.0	-	-	4186_4:114199081-114199081 C>G_AKLLLQRRAAADCAGKNGLTPLHVA	0.0
3:193366627-193366627 T>A	1.0	4196	COLORECTAL	-	-	-	-	OPA1	NM_015560,p.V605D|NM_130835,p.V624D|ENST00000361510,p.V660D|NM_130831,p.V569D|ENST00000361715,p.V624D|NM_130834,p.V623D|uc003ftn.3,p.V569D|ENST00000392438,p.V605D|uc003fth.3,p.V624D|NM_130833,p.V606D|uc003ftg.3,p.V660D|NM_130836,p.V642D|uc003fti.3,p.V642D|uc003ftj.3,p.V623D|ENST00000361150,p.V606D|NM_130837,p.V660D|ENST00000361828,p.V623D|NM_130832,p.V587D|uc003ftk.3,p.V606D|uc003ftl.3,p.V587D|ENST00000361908,p.V642D|uc003ftm.3,p.V605D	retained_intron, protein_coding, processed_transcript	uc003ftn.3	nonsynonymous SNV	exon18	c.T1706A	p.V569D	LFEKAKNEILDEVISLSQVTPKHWE	LFEKAKNEILDEDISLSQVTPKHWE	10.0	3.0	-	-	4196_3:193366627-193366627 T>A_LFEKAKNEILDEDISLSQVTPKHWE	0.0
4:70455287-70455288 CG>-	0.0	4326	BREAST	-	-	-	-	UGT2A1,UGT2A2	NM_001301233,p.I427fs|NM_001105677,p.I471fs|NM_001252275,p.I462fs|ENST00000457664,p.I471fs|uc010iht.3,p.I418fs|ENST00000514019,p.I628fs|NM_001301239,p.I418fs|NM_006798,p.I462fs|uc010ihs.3,p.I471fs|ENST00000286604,p.I462fs|ENST00000503640,p.I462fs|uc010ihu.3,p.I462fs|uc021xox.1,p.I427fs|uc011caq.2,p.I628fs|uc003hem.4,p.I462fs|ENST00000512704,p.I418fs|NM_001252274,p.I628fs	 protein_coding, processed_transcript,retained_intron	uc021xox.1	frameshift deletion	exon5	c.1281_1282del	p.I427fs	QPVKPLDRAVFWIEFVMRHKGAKHLR	QPVKPLDRAVFWIVCHAPQRSQAPSGCSP	1.0	3.0	-	-	4326_4:70455287-70455288 CG>-_QPVKPLDRAVFWIVCHAPQRSQAPSGCSP	0.0
20:16360725-16360725 C>T	1.0	4266	COLORECTAL	-	-	ID=COSM1410505,COSM1410504;OCCURENCE=1(large_intestine)	-	KIF16B	uc010gch.2,p.R641H|NM_001199866,p.R641H|ENST00000354981,p.R641H|NM_024704,p.R641H|uc002wpe.1,p.R23H|uc002wpf.1,p.R23H|uc010gci.2,p.R641H|NM_001199865,p.R641H|ENST00000355755,p.R641H|uc010gcj.2,p.R652H|uc002wpg.2,p.R641H|ENST00000408042,p.R641H	protein_coding	uc010gcj.2	nonsynonymous SNV	exon20	c.G1955A	p.R652H	ELERMQQEVETQRKETEIVQLQIRK	ELERMQQEVETQHKETEIVQLQIRK	7.0	4.0	-	-	4266_20:16360725-16360725 C>T_ELERMQQEVETQHKETEIVQLQIRK	0.0
17:4349457-4349457 G>A	0.0	4278	COLORECTAL	-	-	-	-	SPNS3	ENST00000355530,p.V173M|ENST00000333476,p.V46M|uc002fxt.3,p.V173M|NM_182538,p.V173M|uc002fxu.3,p.V46M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002fxu.3	nonsynonymous SNV	exon3	c.G136A	p.V46M	LGDLFVRDQRTRVLAVFYIFIPVGS	LGDLFVRDQRTRMLAVFYIFIPVGS	6.0	10.0	-	-	4278_17:4349457-4349457 G>A_LGDLFVRDQRTRMLAVFYIFIPVGS	0.0
9:34726204-34726204 G>A	0.0	3795	MELANOMA	0.19	rs521574	ID=COSM3952674,COSM3952675;OCCURENCE=1(lung),2(thyroid)	-	FAM205A	uc011lor.2,p.P345S|ENST00000378788,p.P345S|NM_001141917,p.P345S	protein_coding	uc011lor.2	nonsynonymous SNV	exon4	c.C1033T	p.P345S	NDQPVSFNLKNTPQVSLHRFETISL	NDQPVSFNLKNTSQVSLHRFETISL	1.0	2.0	-	-	3795_9:34726204-34726204 G>A_NDQPVSFNLKNTSQVSLHRFETISL	0.0
3:186504049-186504049 A>T	1.0	4246	COLORECTAL	-	-	-	1	EIF4A2	NM_001967,p.N205I|ENST00000440191,p.N206I|ENST00000425053,p.N205I|uc003fqv.3,p.N110I|uc003fqs.3,p.N205I|ENST00000356531,p.N110I|uc003fqw.3,p.N110I|uc011bsb.2,p.N78I|ENST00000323963,p.N205I|uc003fqu.3,p.N206I	retained_intron, protein_coding, nonsense_mediated_decay	uc011bsb.2	nonsynonymous SNV	exon2	c.A233T	p.N78I	FKDQIYEIFQKLNTSIQVVLLSATM	FKDQIYEIFQKLITSIQVVLLSATM	10.0	4.0	-	-	4246_3:186504049-186504049 A>T_FKDQIYEIFQKLITSIQVVLLSATM	0.0
9:136314989-136314989 G>A	0.0	4078	GASTRIC	-	-	-	-	ADAMTS13	NM_139026,p.E952K|uc004cdp.4,p.E210K|uc004cdw.4,p.E983K|ENST00000371929,p.E983K|uc004cdu.1,p.E952K|ENST00000356589,p.E952K|uc004cdv.4,p.E983K|NM_139025,p.E983K|NM_139027,p.E983K|ENST00000355699,p.E983K|uc004cdt.1,p.E983K|uc004cdz.4,p.E653K|uc004cdx.4,p.E952K	protein_coding, processed_transcript, nonsense_mediated_decay	uc004cdz.4	nonsynonymous SNV	exon16	c.G1957A	p.E653K	VRRILYCARAHGEDDGEEILLDTQC	VRRILYCARAHGKDDGEEILLDTQC	3.0	10.0	-	-	4078_9:136314989-136314989 G>A_VRRILYCARAHGKDDGEEILLDTQC	0.0
X:53966804-53966804 G>A	1.0	3879	MELANOMA	-	-	-	-	PHF8	ENST00000338946,p.S831F|uc004dst.3,p.S932F|NM_001184897,p.S831F|NM_001184896,p.S968F|ENST00000338154,p.S932F|uc004dsw.3,p.S831F|uc004dsu.3,p.S968F|uc004dsv.3,p.S798F|NM_015107,p.S932F|ENST00000357988,p.S968F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004dsw.3	nonsynonymous SNV	exon20	c.C2492T	p.S831F	PTVAATPQLVTSSSPLPPPEPKQEA	PTVAATPQLVTSFSPLPPPEPKQEA	7.0	10.0	-	-	3879_X:53966804-53966804 G>A_PTVAATPQLVTSFSPLPPPEPKQEA	0.0
3:101540697-101540697 A>C	0.0	4246	COLORECTAL	-	-	-	-	NXPE3	ENST00000477909,p.T527P|uc010hpn.3,p.T527P|ENST00000491511,p.T527P|ENST00000273347,p.T527P|NM_001134456,p.T527P|NM_145037,p.T527P|ENST00000422132,p.T527P|uc003dvn.3,p.T527P	protein_coding, processed_transcript	uc010hpn.3	nonsynonymous SNV	exon8	c.A1579C	p.T527P	GVGVYLVDAWEMTLAHYLPHKLHPD	GVGVYLVDAWEMPLAHYLPHKLHPD	5.0	6.0	-	-	4246_3:101540697-101540697 A>C_GVGVYLVDAWEMPLAHYLPHKLHPD	0.0
12:124827700-124827700 G>A	1.0	3466	MELANOMA	-	-	-	1	NCOR2	uc010tba.2,p.P1604L|ENST00000429285,p.P1586L|ENST00000404121,p.P1157L|ENST00000356219,p.P1603L|uc010tbc.2,p.P1586L|NM_001077261,p.P1586L|NM_006312,p.P1596L|uc010tbb.2,p.P1596L|ENST00000397355,p.P1587L|uc021rgc.1,p.P1586L|ENST00000404621,p.P1586L|ENST00000405201,p.P1596L|NM_001206654,p.P1586L	retained_intron, protein_coding	uc021rgc.1	nonsynonymous SNV	exon34	c.C4757T	p.P1586L	KLTSTPREIAKSPHSTVPEHHPHPI	KLTSTPREIAKSLHSTVPEHHPHPI	9.0	9.0	-	-	3466_12:124827700-124827700 G>A_KLTSTPREIAKSLHSTVPEHHPHPI	0.0
1:248569312-248569312 A>T	0.0	4326	BREAST	-	-	-	-	OR2T1	NM_030904,p.Y6F|ENST00000366474,p.Y6F|uc010pzm.2,p.Y6F	protein_coding	uc010pzm.2	nonsynonymous SNV	exon1	c.A17T	p.Y6F	MWQEYYFLNVFFPLLKVC	MWQEYFFLNVFFPLLKVC	1.0	2.0	-	-	4326_1:248569312-248569312 A>T_MWQEYFFLNVFFPLLKVC	0.0
X:152801800-152801800 C>T	0.0	4284	COLORECTAL	-	-	ID=COSM1184076,COSM1184077,COSM1184075,COSM1184074;OCCURENCE=1(large_intestine)	1	ATP2B3	ENST00000263519,p.A32V|NM_021949,p.A32V|uc004fhs.1,p.A32V|ENST00000370181,p.A32V|ENST00000359149,p.A32V|ENST00000349466,p.A32V|NM_001001344,p.A32V|ENST00000370186,p.A32V|ENST00000393842,p.A32V|uc004fht.1,p.A32V	protein_coding, processed_transcript	uc004fht.1	nonsynonymous SNV	exon1	c.C95T	p.A32V	DVPQAGGFGCTLAELRTLMELRGAE	DVPQAGGFGCTLVELRTLMELRGAE	1.0	10.0	-	-	4284_X:152801800-152801800 C>T_DVPQAGGFGCTLVELRTLMELRGAE	0.0
1:118558776-118558776 C>T	0.0	4301	MELANOMA	-	-	-	-	SPAG17	uc001ehk.2,p.A1367T|NM_206996,p.A1367T|ENST00000336338,p.A1367T	protein_coding, processed_transcript	uc001ehk.2	nonsynonymous SNV	exon29	c.G4099A	p.A1367T	KKGKSHKSQSSMAHKGEIHDPPPEA	KKGKSHKSQSSMTHKGEIHDPPPEA	3.0	1.0	-	-	4301_1:118558776-118558776 C>T_KKGKSHKSQSSMTHKGEIHDPPPEA	0.0
7:44151591-44151591 C>G	0.0	4160	COLORECTAL	-	-	-	-	AEBP1	uc003tkc.5,p.T235R|NM_001129,p.T660R|uc003tkb.4,p.T660R|ENST00000450684,p.T235R|ENST00000223357,p.T660R	protein_coding, processed_transcript, nonsense_mediated_decay	uc003tkc.5	nonsynonymous SNV	exon3	c.C704G	p.T235R	DGNPRVRSLVQDTRIHLVPSLNPDG	DGNPRVRSLVQDRRIHLVPSLNPDG	9.0	2.0	-	-	4160_7:44151591-44151591 C>G_DGNPRVRSLVQDRRIHLVPSLNPDG	0.0
18:2750075-2750075 A>G	1.0	4037	NSCLC	-	-	-	-	SMCHD1	ENST00000320876,p.E1321G|NM_015295,p.E1321G|uc002klm.4,p.E1321G|ENST00000261598,p.E1321G|ENST00000577880,p.E792G	retained_intron, protein_coding, nonsense_mediated_decay	uc002klm.4	nonsynonymous SNV	exon31	c.A3962G	p.E1321G	KLMPSNQQHKTDEKGRANLGVFSVF	KLMPSNQQHKTDGKGRANLGVFSVF	7.0	7.0	-	-	4037_18:2750075-2750075 A>G_KLMPSNQQHKTDGKGRANLGVFSVF	0.0
1:1560723-1560723 G>A	1.0	3466	MELANOMA	-	-	-	-	MIB2	ENST00000357210,p.G318E|ENST00000355826,p.G361E|uc009vkh.3,p.G159E|NM_001170687,p.G361E|NM_001170689,p.G195E|uc001agg.3,p.G375E|ENST00000504599,p.G274E|NM_001170686,p.G375E|ENST00000378710,p.G318E|ENST00000505820,p.G375E|uc001agi.3,p.G375E|uc001agj.3,p.G159E|NM_080875,p.G375E|uc010nyq.2,p.G274E|ENST00000520777,p.G375E|ENST00000487053,p.G274E|NM_001170688,p.G310E|ENST00000378712,p.G195E|uc001agh.3,p.G361E|ENST00000360522,p.G318E|ENST00000378708,p.G260E|uc001agk.3,p.G310E|uc001agl.2,p.G274E|uc001agm.3,p.G195E|ENST00000518681,p.G310E|ENST00000506488,p.G260E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010nyq.2	nonsynonymous SNV	exon6	c.G821A	p.G274E	RRVSADSQPFQHGDKVKCLLDTDVL	RRVSADSQPFQHEDKVKCLLDTDVL	6.0	8.0	-	-	3466_1:1560723-1560723 G>A_RRVSADSQPFQHEDKVKCLLDTDVL	0.0
17:7577568-7577568 C>T	1.0	4320	COLORECTAL	-	-	ID=COSM3388191,COSM1649400,COSM179812,COSM179813,COSM11059,COSM179811;OCCURENCE=2(endometrium),5(soft_tissue),5(ovary),9(large_intestine),7(pancreas),1(skin),12(breast),7(oesophagus),1(bone),1(upper_aerodigestive_tract),1(stomach),4(central_nervous_system),8(haematopoietic_and_lymphoid_tissue),2(lung)	1	TP53	uc010cnh.2,p.C238Y|uc002gim.3,p.C238Y|uc010cni.2,p.C238Y	retained_intron, protein_coding, processed_transcript	uc010cni.2	nonsynonymous SNV	exon7	c.G713A	p.C238Y	LGRNSFEVRVCACPGRDRRTEEENL	LGRNSFEVRVCAYPGRDRRTEEENL	10.0	10.0	-	-	4320_17:7577568-7577568 C>T_LGRNSFEVRVCAYPGRDRRTEEENL	0.0
X:55033431-55033431 G>C	0.0	4317	COLORECTAL	-	-	-	-	APEX2	NM_014481,p.V374L|ENST00000374987,p.V374L|NM_001271748,p.V203L|uc004dtz.4,p.V374L|uc011mom.3,p.V203L	protein_coding, processed_transcript	uc011mom.3	nonsynonymous SNV	exon5	c.G607C	p.V203L	QTRVQTCQNKAQVRSTRPQPSQVGS	QTRVQTCQNKAQLRSTRPQPSQVGS	6.0	4.0	-	-	4317_X:55033431-55033431 G>C_QTRVQTCQNKAQLRSTRPQPSQVGS	0.0
3:129159200-129159200 T>A	1.0	4317	COLORECTAL	-	-	-	-	IFT122	uc003emm.3,p.D9E|uc003eml.3,p.D9E|uc011bkx.1,p.D9E|NM_052990,p.D9E|ENST00000507564,p.D9E|ENST00000348417,p.D9E|uc010htc.3,p.D9E|uc003emn.3,p.D9E|ENST00000349441,p.D9E|ENST00000504021,p.D9E|NM_052985,p.D9E|NM_018262,p.D9E|NM_001280541,p.D9E|NM_052989,p.D9E|uc003emo.3,p.D9E|ENST00000512220,p.D9E|ENST00000296266,p.D9E|ENST00000347300,p.D9E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bkx.1	nonsynonymous SNV	exon1	c.T27A	p.D9E	MRAVLTWRDKAEHCINDIAFK	MRAVLTWREKAEHCINDIAFK	9.0	5.0	-	-	4317_3:129159200-129159200 T>A_MRAVLTWREKAEHCINDIAFK	0.0
1:53287176-53287176 C>T	1.0	3713	MELANOMA	-	-	-	-	ZYG11B	NM_024646,p.H704Y|uc010onj.2,p.H625Y|ENST00000294353,p.H704Y|uc001cuj.3,p.H704Y|uc009vzh.3,p.H126Y|ENST00000443756,p.H634Y	protein_coding	uc010onj.2	nonsynonymous SNV	exon12	c.C1873T	p.H625Y	EGGLQHLYNIKDHEHTDPHVQQIAV	EGGLQHLYNIKDYEHTDPHVQQIAV	6.0	1.0	-	-	3713_1:53287176-53287176 C>T_EGGLQHLYNIKDYEHTDPHVQQIAV	0.0
1:159900545-159900545 C>T	1.0	4316	COLORECTAL	-	-	-	-	IGSF9	uc001fuq.2,p.V568M|NM_001135050,p.V584M|uc001fur.2,p.V584M|ENST00000361509,p.V568M|NM_020789,p.V568M|ENST00000368094,p.V584M	protein_coding, processed_transcript	uc001fur.2	nonsynonymous SNV	exon14	c.G1750A	p.V584M	PGLQPHTQYQFSVLAQNKLGSGPFS	PGLQPHTQYQFSMLAQNKLGSGPFS	6.0	10.0	-	-	4316_1:159900545-159900545 C>T_PGLQPHTQYQFSMLAQNKLGSGPFS	0.0
14:20784558-20784558 C>A	1.0	4258	ENDOMETRIAL	-	-	-	1	CCNB1IP1	uc001vwz.4,p.S42I|uc001vwx.4,p.S42I|ENST00000398169,p.S42I|ENST00000556854,p.S42I|ENST00000398163,p.S42I|ENST00000353689,p.S42I|ENST00000437553,p.S42I|uc001vwy.4,p.S42I|NM_182849,p.S42I|NM_182852,p.S42I|uc021rnp.2,p.S42I|ENST00000358932,p.S42I|NM_021178,p.S42I|ENST00000557665,p.S42I|uc001vwv.4,p.S42I|ENST00000398160,p.S42I	protein_coding, processed_transcript, nonsense_mediated_decay	uc021rnp.2	nonsynonymous SNV	exon6	c.G125T	p.S42I	HIFCDQHGSGEFSRSPAICPACNST	HIFCDQHGSGEFIRSPAICPACNST	10.0	8.0	-	-	4258_14:20784558-20784558 C>A_HIFCDQHGSGEFIRSPAICPACNST	0.0
17:34199413-34199413 G>A	0.0	3919	MELANOMA	-	-	-	-	CCL5	ENST00000366113,p.R82W|ENST00000293272,p.R82W|NM_002985,p.R82W|uc002hkf.3,p.R82W	protein_coding	uc002hkf.3	nonsynonymous SNV	exon3	c.C244T	p.R82W	RQVCANPEKKWVREYINSLEMS	RQVCANPEKKWVWEYINSLEMS	7.0	10.0	-	-	3919_17:34199413-34199413 G>A_RQVCANPEKKWVWEYINSLEMS	0.0
7:82585131-82585131 C>T	0.0	2369	MELANOMA	-	-	-	-	PCLO	NM_033026,p.R1713K|ENST00000333891,p.R1713K|NM_014510,p.R1713K|uc003uhv.2,p.R1713K|uc003uhx.2,p.R1713K|ENST00000423517,p.R1713K	protein_coding, processed_transcript, nonsense_mediated_decay	uc003uhx.2	nonsynonymous SNV	exon5	c.G5138A	p.R1713K	MESLTDSPEDRSRGEGSSSLHASSF	MESLTDSPEDRSKGEGSSSLHASSF	10.0	5.0	-	-	2369_7:82585131-82585131 C>T_MESLTDSPEDRSKGEGSSSLHASSF	0.0
7:100087104-100087104 A>C	0.0	4245	COLORECTAL	-	-	-	-	NYAP1	ENST00000423930,p.K587T|NM_173564,p.K587T|uc003uvd.2,p.K587T|ENST00000454988,p.K530T|ENST00000300179,p.K587T|uc003uve.2,p.K369T	protein_coding, processed_transcript	uc003uve.2	nonsynonymous SNV	exon1	c.A1106C	p.K369T	KGCGVGAPSPMVKIQLQEQGTDGGA	KGCGVGAPSPMVTIQLQEQGTDGGA	4.0	3.0	-	-	4245_7:100087104-100087104 A>C_KGCGVGAPSPMVTIQLQEQGTDGGA	0.0
2:240003853-240003853 G>A	1.0	3903	MELANOMA	-	-	-	-	HDAC4	uc010fyy.3,p.S818F|uc002vyk.4,p.S861F|NM_006037,p.S861F|ENST00000345617,p.S861F|ENST00000543185,p.S445F	retained_intron, protein_coding, processed_transcript	uc010fyy.3	nonsynonymous SNV	exon18	c.C2453T	p.S818F	QAFYSDPSVLYMSLHRYDDGNFFPG	QAFYSDPSVLYMFLHRYDDGNFFPG	7.0	9.0	-	-	3903_2:240003853-240003853 G>A_QAFYSDPSVLYMFLHRYDDGNFFPG	0.0
X:69263813-69263813 C>T	0.0	4110	BILE DUCT	0	-	ID=COSM1124347;OCCURENCE=3(endometrium)	-	AWAT2	NM_001002254,p.R77H|uc004dxt.1,p.R77H|ENST00000276101,p.R77H	retained_intron, protein_coding, nonsense_mediated_decay	uc004dxt.1	nonsynonymous SNV	exon3	c.G230A	p.R77H	RGGRRFTCVRHWRLWKHYSDYFPLK	RGGRRFTCVRHWHLWKHYSDYFPLK	1.0	10.0	-	-	4110_X:69263813-69263813 C>T_RGGRRFTCVRHWHLWKHYSDYFPLK	0.0
5:140307549-140307549 G>C	0.0	4081	COLORECTAL	-	-	-	-	PCDHAC1	ENST00000253807,p.V358L|uc003lig.1,p.V358L|NM_018898,p.V358L|ENST00000409700,p.V358L|uc003lih.2,p.V358L|NM_031882,p.V358L	protein_coding	uc003lih.2	nonsynonymous SNV	exon1	c.G1072C	p.V358L	SNPVPEDAAPGTVIALFSVKDEDLD	SNPVPEDAAPGTLIALFSVKDEDLD	2.0	4.0	-	-	4081_5:140307549-140307549 G>C_SNPVPEDAAPGTLIALFSVKDEDLD	0.0
1:228403297-228403297 C>T	0.0	4278	COLORECTAL	-	-	-	-	OBSCN	NM_001271223,p.A621V|ENST00000284548,p.A621V|ENST00000570156,p.A621V|NM_052843,p.A621V|uc001hsn.4,p.A621V|uc001hsq.2,p.A621V|ENST00000422127,p.A621V|uc009xez.2,p.A621V|NM_001098623,p.A621V	retained_intron, protein_coding, processed_transcript	uc009xez.2	nonsynonymous SNV	exon6	c.C1862T	p.A621V	LAPKLAVRTPLKAVQAVEGGEVTFS	LAPKLAVRTPLKVVQAVEGGEVTFS	8.0	10.0	-	-	4278_1:228403297-228403297 C>T_LAPKLAVRTPLKVVQAVEGGEVTFS	0.0
12:58001221-58001221 C>T	1.0	3879	MELANOMA	-	-	-	-	DTX3	NM_001286246,p.A192V|ENST00000548198,p.A192V|NM_178502,p.A192V|uc001sov.1,p.A185V|ENST00000551632,p.A195V|ENST00000548804,p.A192V|uc001soy.1,p.A185V|uc001sow.1,p.A192V|uc001sox.1,p.A185V|NM_001286245,p.A195V|ENST00000337737,p.A192V	protein_coding	uc001soy.1	nonsynonymous SNV	exon3	c.C554T	p.A185V	CRHSFCEGCITRALQVKKACPMCGR	CRHSFCEGCITRVLQVKKACPMCGR	6.0	4.0	-	-	3879_12:58001221-58001221 C>T_CRHSFCEGCITRVLQVKKACPMCGR	0.0
17:16981361-16981361 G>A	1.0	4155	MELANOMA	-	-	-	-	MPRIP	NM_015134,p.G80S|ENST00000577514,p.G80S|ENST00000395804,p.G80S|uc002gqu.2,p.G80S|ENST00000444976,p.G80S|ENST00000341712,p.G80S|ENST00000395811,p.G80S|uc002gqv.2,p.G80S|NM_201274,p.G80S	retained_intron, protein_coding, processed_transcript	uc002gqv.2	nonsynonymous SNV	exon3	c.G238A	p.G80S	KWQRRFFILYEHGLLRYALDEMPTT	KWQRRFFILYEHSLLRYALDEMPTT	10.0	8.0	-	-	4155_17:16981361-16981361 G>A_KWQRRFFILYEHSLLRYALDEMPTT	0.0
2:95691589-95691589 G>T	1.0	4129	NSCLC	-	-	-	-	MAL	ENST00000309988,p.V18F|ENST00000354078,p.V18F|ENST00000349807,p.V18F|ENST00000353004,p.V18F|NM_022438,p.V18F|NM_022440,p.V18F|NM_022439,p.V18F|uc002stz.2,p.V18F|uc002sty.2,p.V18F|uc002sua.2,p.V18F|uc002stx.2,p.V18F|NM_002371,p.V18F	protein_coding, processed_transcript	uc002sua.2	nonsynonymous SNV	exon1	c.G52T	p.V18F	ATGGSTLPSGFSVFTTLPDLLFIFE	ATGGSTLPSGFSFFTTLPDLLFIFE	9.0	9.0	-	-	4129_2:95691589-95691589 G>T_ATGGSTLPSGFSFFTTLPDLLFIFE	0.0
6:46826789-46826789 C>T	0.0	2359	MELANOMA	-	-	-	-	GPR116	ENST00000456426,p.E809K|uc003oyo.3,p.E951K|NM_015234,p.E951K|ENST00000545669,p.E380K|uc003oyp.3,p.E809K|ENST00000362015,p.E951K|uc011dwj.1,p.E506K|ENST00000265417,p.E951K|uc011dwk.1,p.E380K|uc010jzi.1,p.E623K|uc003oyq.3,p.E951K|ENST00000283296,p.E951K|NM_001098518,p.E951K	protein_coding, processed_transcript	uc011dwk.1	nonsynonymous SNV	exon7	c.G1138A	p.E380K	SMTFKNNSPSGGETKCVFWNFRLAN	SMTFKNNSPSGGKTKCVFWNFRLAN	1.0	8.0	-	-	2359_6:46826789-46826789 C>T_SMTFKNNSPSGGKTKCVFWNFRLAN	0.0
11:64514789-64514789 C>T	0.0	4213	COLORECTAL	-	-	-	-	PYGM	uc001oax.4,p.R740Q|NM_005609,p.R740Q|NM_001164716,p.R652Q|ENST00000164139,p.R740Q|uc001oay.4,p.R652Q|ENST00000377432,p.R652Q	retained_intron, protein_coding, processed_transcript	uc001oay.4	nonsynonymous SNV	exon16	c.G1955A	p.R652Q	NAQEYYDRIPELRQVIEQLSSGFFS	NAQEYYDRIPELQQVIEQLSSGFFS	6.0	9.0	-	-	4213_11:64514789-64514789 C>T_NAQEYYDRIPELQQVIEQLSSGFFS	0.0
1:10460562-10460562 A>T	1.0	4287	COLORECTAL	-	-	-	-	PGD	ENST00000538557,p.K53M|NM_002631,p.K66M|ENST00000270776,p.K66M|uc001arc.3,p.K66M|ENST00000465632,p.K53M|ENST00000491493,p.K53M|uc010oak.2,p.K66M|ENST00000541529,p.K66M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010oak.2	nonsynonymous SNV	exon3	c.A197T	p.K66M	GAQSLKEMVSKLKKPRRIILLVKAG	GAQSLKEMVSKLMKPRRIILLVKAG	9.0	2.0	-	-	4287_1:10460562-10460562 A>T_GAQSLKEMVSKLMKPRRIILLVKAG	0.0
X:49143014-49143014 C>A	0.0	4287	COLORECTAL	-	-	-	-	PPP1R3F	uc004dni.3,p.A275E|uc004dnj.2,p.A275E|ENST00000438316,p.A292E|uc004dnh.2,p.A621E|ENST00000055335,p.A621E|ENST00000495799,p.A275E|NM_001184745,p.A275E|NM_033215,p.A621E|ENST00000376188,p.A275E|uc011mnd.2,p.A292E|ENST00000466508,p.A275E	protein_coding	uc011mnd.2	nonsynonymous SNV	exon5	c.C875A	p.A292E	VVATMGDVWLPWAEGSGCDGPVVLG	VVATMGDVWLPWEEGSGCDGPVVLG	4.0	7.0	-	-	4287_X:49143014-49143014 C>A_VVATMGDVWLPWEEGSGCDGPVVLG	0.0
4:125591242-125591242 A>C	1.0	4320	COLORECTAL	-	-	-	-	ANKRD50	ENST00000504087,p.L1064V|NM_020337,p.L1064V|ENST00000515641,p.L885V|uc011cgo.2,p.L885V|uc010inw.3,p.L1064V|NM_001167882,p.L885V	protein_coding	uc011cgo.2	nonsynonymous SNV	exon3	c.T2653G	p.L885V	AAQEGHIDVVQVLLEHGADPNHADQ	AAQEGHIDVVQVVLEHGADPNHADQ	6.0	6.0	-	-	4320_4:125591242-125591242 A>C_AAQEGHIDVVQVVLEHGADPNHADQ	0.0
1:182442751-182442751 A>C	0.0	4246	COLORECTAL	-	-	-	-	RGSL1	ENST00000443996,p.T204P|uc009wxw.3,p.T169P|NM_001137669,p.T169P|uc021pfx.1,p.T204P|ENST00000294854,p.T169P|ENST00000542961,p.T204P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pfx.1	nonsynonymous SNV	exon7	c.A610C	p.T204P	LLNLSIWHPNQSTTRREILSHMQKV	LLNLSIWHPNQSPTRREILSHMQKV	1.0	4.0	-	-	4246_1:182442751-182442751 A>C_LLNLSIWHPNQSPTRREILSHMQKV	0.0
19:36590514-36590514 A>G	1.0	4320	COLORECTAL	-	-	-	-	WDR62	ENST00000270301,p.S912G|uc002odd.2,p.S912G|NM_001083961,p.S912G|ENST00000401500,p.S912G|uc002odc.2,p.S912G|NM_173636,p.S912G	protein_coding, processed_transcript, nonsense_mediated_decay	uc002odd.2	nonsynonymous SNV	exon22	c.A2734G	p.S912G	DSLEPQSLASLLSESESPQEAGRGH	DSLEPQSLASLLGESESPQEAGRGH	7.0	1.0	-	-	4320_19:36590514-36590514 A>G_DSLEPQSLASLLGESESPQEAGRGH	0.0
15:22928198-22928198 A>G	0.0	4238	COLORECTAL	-	-	-	-	CYFIP1	NM_001287810,p.I93V|ENST00000560848,p.I93V|ENST00000561274,p.I93V|ENST00000561185,p.I93V|uc001yut.3,p.I93V|uc001yus.3,p.I93V|ENST00000313077,p.I93V|NM_014608,p.I93V|uc010aya.1,p.I121V	retained_intron, protein_coding, nonsense_mediated_decay	uc010aya.1	nonsynonymous SNV	exon3	c.A361G	p.I121V	VMLYTWRSCSRAIPQVKCNEQPNRV	VMLYTWRSCSRAVPQVKCNEQPNRV	8.0	5.0	CD8	-	4238_15:22928198-22928198 A>G_VMLYTWRSCSRAVPQVKCNEQPNRV	1.0
17:56345258-56345258 G>A	0.0	4246	COLORECTAL	-	-	-	-	LPO	uc010wns.2,p.R622Q|uc010dcq.3,p.R352Q|NM_001160102,p.R598Q|NM_006151,p.R681Q|uc002ivt.3,p.R681Q|ENST00000582328,p.R598Q|uc010dcp.3,p.R598Q|uc010dcr.3,p.R244Q|ENST00000543544,p.R622Q|ENST00000421678,p.R598Q|ENST00000262290,p.R681Q	retained_intron, protein_coding, nonsense_mediated_decay	uc010wns.2	nonsynonymous SNV	exon12	c.G1865A	p.R622Q	LVCDNTRITKVPRDPFWANSYPYDF	LVCDNTRITKVPQDPFWANSYPYDF	3.0	10.0	-	-	4246_17:56345258-56345258 G>A_LVCDNTRITKVPQDPFWANSYPYDF	0.0
3:97851849-97851849 C>T	0.0	3795	MELANOMA	-	-	ID=COSM137858;OCCURENCE=1(skin)	-	OR5H1	NM_001005338,p.S103L|ENST00000354565,p.S103L|uc011bgt.2,p.S103L	protein_coding	uc011bgt.2	nonsynonymous SNV	exon1	c.C308T	p.S103L	MISLSECKIQFFSFAISVTTECFLL	MISLSECKIQFFLFAISVTTECFLL	1.0	8.0	-	-	3795_3:97851849-97851849 C>T_MISLSECKIQFFLFAISVTTECFLL	0.0
7:82544065-82544065 C>A	0.0	4046	OVARIAN	-	-	-	-	PCLO	ENST00000437081,p.G1133C|ENST00000423517,p.G4413C|uc003uhx.2,p.G4413C|NM_014510,p.G4413C|ENST00000333891,p.G4413C|uc003uhv.2,p.G4413C|NM_033026,p.G4413C|uc010lec.3,p.G1378C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010lec.3	nonsynonymous SNV	exon2	c.G4132T	p.G1378C	VQQHMREESRTRGYDRDIAFIMDDF	VQQHMREESRTRCYDRDIAFIMDDF	3.0	6.0	-	-	4046_7:82544065-82544065 C>A_VQQHMREESRTRCYDRDIAFIMDDF	0.0
8:29102955-29102955 C>T	1.0	4301	MELANOMA	-	-	-	-	KIF13B	ENST00000523968,p.D53N	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000523968	nonsynonymous SNV	exon3	c.G157A	p.D53N	LSWTSGPEEVKRD	LSWTSGPEEVKRN	7.0	4.0	-	-	4301_8:29102955-29102955 C>T_LSWTSGPEEVKRN	0.0
22:42003322-42003322 C>A	0.0	4317	COLORECTAL	-	-	-	-	DESI1	NM_015704,p.V42F|ENST00000263256,p.V42F|uc003bam.2,p.V42F	retained_intron, protein_coding, processed_transcript	uc003bam.2	nonsynonymous SNV	exon3	c.G124T	p.V42F	GKQLEGIWHTSIVVHKDEFFFGSGG	GKQLEGIWHTSIFVHKDEFFFGSGG	8.0	3.0	-	-	4317_22:42003322-42003322 C>A_GKQLEGIWHTSIFVHKDEFFFGSGG	0.0
1:70504172-70504172 C>T	1.0	3713	MELANOMA	-	-	-	-	LRRC7	ENST00000310961,p.P856S|uc001deq.3,p.P92S|uc009wbg.3,p.P135S|NM_020794,p.P851S|ENST00000415775,p.P135S|uc001dep.3,p.P851S|ENST00000035383,p.P851S	protein_coding, processed_transcript, nonsense_mediated_decay	uc009wbg.3	nonsynonymous SNV	exon15	c.C403T	p.P135S	SNPWQNWTRTPSPFEDRTAFPSKLE	SNPWQNWTRTPSSFEDRTAFPSKLE	1.0	4.0	-	-	3713_1:70504172-70504172 C>T_SNPWQNWTRTPSSFEDRTAFPSKLE	0.0
16:80642126-80642126 C>T	0.0	4240	BREAST	-	-	-	-	CDYL2	uc002ffs.3,p.E409K|NM_152342,p.E409K|ENST00000566173,p.E410K|ENST00000562812,p.E410K|ENST00000299564,p.E409K|ENST00000563890,p.E410K	protein_coding, processed_transcript	uc002ffs.3	nonsynonymous SNV	exon6	c.G1225A	p.E409K	TFPQILGVALANEMLFCGRKLTAQE	TFPQILGVALANKMLFCGRKLTAQE	6.0	8.0	-	-	4240_16:80642126-80642126 C>T_TFPQILGVALANKMLFCGRKLTAQE	0.0
X:154294035-154294035 C>A	0.0	4234	NSCLC	-	-	-	1	MTCP1	ENST00000369476,p.Q45H|ENST00000362018,p.Q45H|uc004fmz.2,p.Q45H|NM_001018025,p.Q45H	protein_coding, processed_transcript, nonsense_mediated_decay	uc004fmz.2	nonsynonymous SNV	exon3	c.G135T	p.Q45H	VEEETSFLRARVQQIQVPLGDAARP	VEEETSFLRARVHQIQVPLGDAARP	7.0	3.0	-	-	4234_X:154294035-154294035 C>A_VEEETSFLRARVHQIQVPLGDAARP	0.0
20:57036021-57036021 C>T	1.0	4160	COLORECTAL	-	-	ID=COSM1245181;OCCURENCE=1(oesophagus),1(breast)	-	APCDD1L	ENST00000371149,p.R444H|NM_153360,p.R444H|ENST00000439429,p.R455H|uc010zzp.1,p.R455H|uc002xze.1,p.R444H	protein_coding, processed_transcript	uc010zzp.1	nonsynonymous SNV	exon5	c.G1364A	p.R455H	PTDGSSPDTPEKRPTSYQAPLVLCH	PTDGSSPDTPEKHPTSYQAPLVLCH	5.0	3.0	-	-	4160_20:57036021-57036021 C>T_PTDGSSPDTPEKHPTSYQAPLVLCH	0.0
14:60938456-60938456 C>T	1.0	3879	MELANOMA	-	-	-	-	C14orf39	ENST00000321731,p.E109K|ENST00000555476,p.E80K|uc001xez.4,p.E109K|NM_174978,p.E109K	protein_coding, nonsense_mediated_decay	uc001xez.4	nonsynonymous SNV	exon6	c.G325A	p.E109K	FTVYQGTVEKDKEMYHDYICQYKEV	FTVYQGTVEKDKKMYHDYICQYKEV	4.0	8.0	-	-	3879_14:60938456-60938456 C>T_FTVYQGTVEKDKKMYHDYICQYKEV	0.0
17:48753296-48753296 C>T	1.0	4284	COLORECTAL	-	-	-	-	ABCC3	ENST00000505699,p.T971M|ENST00000285238,p.T971M|uc002isl.3,p.T971M|NM_003786,p.T971M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002isl.3	nonsynonymous SNV	exon22	c.C2912T	p.T971M	FWDYAKAVGLCTTLAICLLYVGQSA	FWDYAKAVGLCTMLAICLLYVGQSA	9.0	5.0	-	-	4284_17:48753296-48753296 C>T_FWDYAKAVGLCTMLAICLLYVGQSA	0.0
16:56855500-56855500 G>C	1.0	4134	NSCLC	-	-	-	-	NUP93	ENST00000563858,p.D10H	retained_intron, protein_coding, processed_transcript, TEC	ENST00000563858	nonsynonymous SNV	exon3	c.G28C	p.D10H	MDTEGFELDDKSISDMWTMVKQ	MDTEGFELDHKSISDMWTMVKQ	9.0	3.0	-	-	4134_16:56855500-56855500 G>C_MDTEGFELDHKSISDMWTMVKQ	0.0
21:42813705-42813705 C>T	0.0	4240	BREAST	-	-	ID=COSM188229;OCCURENCE=1(large_intestine)	-	MX1	uc002yzh.3,p.R265W|ENST00000398598,p.R265W|ENST00000398600,p.R265W|ENST00000288383,p.R242W|uc010goq.3,p.R265W|NM_001282920,p.R265W|NM_001144925,p.R265W|NM_002462,p.R265W|uc002yzi.3,p.R265W|NM_001178046,p.R265W|ENST00000455164,p.R265W	retained_intron, protein_coding, processed_transcript	uc010goq.3	nonsynonymous SNV	exon8	c.C793T	p.R265W	DKGTEDKVVDVVRNLVFHLKKGYMI	DKGTEDKVVDVVWNLVFHLKKGYMI	6.0	7.0	-	-	4240_21:42813705-42813705 C>T_DKGTEDKVVDVVWNLVFHLKKGYMI	0.0
2:1161295-1161295 C>T	1.0	4284	COLORECTAL	0.01	rs61744692	ID=COSM441027;OCCURENCE=1(breast)	-	SNTG2	uc002qwq.3,p.A158V|NM_018968,p.A158V|ENST00000308624,p.A158V	protein_coding, processed_transcript, nonsense_mediated_decay	uc002qwq.3	nonsynonymous SNV	exon7	c.C473T	p.A158V	DEVTITVEYLREAPAFLKLPLGSPG	DEVTITVEYLREVPAFLKLPLGSPG	2.0	10.0	-	-	4284_2:1161295-1161295 C>T_DEVTITVEYLREVPAFLKLPLGSPG	0.0
6:42974688-42974688 A>C	1.0	4320	COLORECTAL	-	-	-	-	PPP2R5D	ENST00000472118,p.K113T|NM_006245,p.K121T|uc003oth.4,p.K121T|ENST00000485511,p.K121T	retained_intron, protein_coding, nonsense_mediated_decay	uc003oth.4	nonsynonymous SNV	exon4	c.A362C	p.K121T	SPTQEREELFIQKLRQCCVLFDFVS	SPTQEREELFIQTLRQCCVLFDFVS	9.0	3.0	-	-	4320_6:42974688-42974688 A>C_SPTQEREELFIQTLRQCCVLFDFVS	0.0
X:147743434-147743434 C>G	0.0	4160	COLORECTAL	-	-	-	-	AFF2	uc004fcp.3,p.N62K|NM_002025,p.N62K|uc011mxb.2,p.N62K|ENST00000370460,p.N62K|NM_001169124,p.N62K	protein_coding	uc011mxb.2	nonsynonymous SNV	exon3	c.C186G	p.N62K	LFGEPYKVAEYTNKGDALANRVQNT	LFGEPYKVAEYTKKGDALANRVQNT	1.0	10.0	-	-	4160_X:147743434-147743434 C>G_LFGEPYKVAEYTKKGDALANRVQNT	0.0
1:77984389-77984389 G>A	1.0	3713	MELANOMA	-	-	-	-	AK5	NM_012093,p.E404K|ENST00000354567,p.E430K|ENST00000344720,p.E404K|NM_174858,p.E430K|uc001dho.3,p.E404K|uc001dhn.3,p.E430K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001dho.3	nonsynonymous SNV	exon11	c.G1210A	p.E404K	ESERSKLIRDIMERGDLVPSGIVLE	ESERSKLIRDIMKRGDLVPSGIVLE	1.0	4.0	-	-	3713_1:77984389-77984389 G>A_ESERSKLIRDIMKRGDLVPSGIVLE	0.0
4:39206793-39206793 A>T	0.0	4335	COLORECTAL	-	-	-	-	WDR19	uc003gtv.3,p.K208M|NM_025132,p.K208M|ENST00000288634,p.K48M|uc003gtu.1,p.K208M|ENST00000399820,p.K208M|uc010ifl.1,p.K25M|ENST00000506503,p.K208M|uc011byi.2,p.K48M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011byi.2	nonsynonymous SNV	exon7	c.A143T	p.K48M	SAAESMISVVLGKKTLFFLNLNEPD	SAAESMISVVLGMKTLFFLNLNEPD	6.0	1.0	-	-	4335_4:39206793-39206793 A>T_SAAESMISVVLGMKTLFFLNLNEPD	0.0
1:100889855-100889855 C>G	0.0	3775	CERVICAL	-	-	-	-	CDC14A	uc009wee.3,p.F129L|ENST00000544534,p.F129L|ENST00000361544,p.F129L|uc001dtf.2,p.F129L|NM_033312,p.F129L|uc001dtg.4,p.F129L|ENST00000455467,p.F130L|NM_033313,p.F129L|ENST00000542213,p.F71L|uc001dte.4,p.F129L|ENST00000336454,p.F129L|ENST00000370124,p.F129L|uc010oui.1,p.F71L|NM_003672,p.F129L|ENST00000370125,p.F129L	protein_coding, processed_transcript	uc010oui.1	nonsynonymous SNV	exon5	c.C213G	p.F71L	ALLSGSNPPYLPFRDASFGNCTYNL	ALLSGSNPPYLPLRDASFGNCTYNL	6.0	8.0	-	-	3775_1:100889855-100889855 C>G_ALLSGSNPPYLPLRDASFGNCTYNL	0.0
13:23913108-23913108 G>C	0.0	4335	COLORECTAL	-	-	-	-	SACS	NM_001278055,p.P1489R|ENST00000382298,p.P1636R|uc001uoo.3,p.P1489R|NM_014363,p.P1636R|ENST00000382292,p.P1636R|uc001uon.3,p.P1636R|ENST00000402364,p.P886R	protein_coding, processed_transcript	uc001uoo.3	nonsynonymous SNV	exon8	c.C4466G	p.P1489R	VFGCQLPLTVEAPYSYNGTLFRLSF	VFGCQLPLTVEARYSYNGTLFRLSF	5.0	7.0	-	-	4335_13:23913108-23913108 G>C_VFGCQLPLTVEARYSYNGTLFRLSF	0.0
4:41263893-41263893 G>A	0.0	4317	COLORECTAL	-	-	-	-	UCHL1	uc003gvp.3,p.A57T|uc003gvo.3,p.A138T|ENST00000505232,p.A138T|ENST00000284440,p.A138T|ENST00000503431,p.A138T|ENST00000512788,p.A138T|NM_004181,p.A138T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gvp.3	nonsynonymous SNV	exon5	c.G169A	p.A57T	PEDRAKCFEKNEAIQAAHDAVAQEG	PEDRAKCFEKNETIQAAHDAVAQEG	3.0	7.0	-	-	4317_4:41263893-41263893 G>A_PEDRAKCFEKNETIQAAHDAVAQEG	0.0
15:86182612-86182612 G>A	1.0	4000	MELANOMA	-	-	ID=COSM1708503,COSM231735;OCCURENCE=2(skin)	-	AKAP13	ENST00000361243,p.R1390Q|uc002blv.2,p.R1390Q|NM_006738,p.R1390Q|NM_007200,p.R1390Q|uc002blt.2,p.R1390Q|uc002blu.2,p.R1390Q|ENST00000559362,p.R1390Q|uc010bne.1,p.R43Q|ENST00000394518,p.R1390Q	retained_intron, protein_coding, processed_transcript	uc010bne.1	nonsynonymous SNV	exon3	c.G128A	p.R43Q	KMKQGPMTQAINRENWCTIEPCPDA	KMKQGPMTQAINQENWCTIEPCPDA	10.0	7.0	-	-	4000_15:86182612-86182612 G>A_KMKQGPMTQAINQENWCTIEPCPDA	0.0
7:116339857-116339857 A>C	1.0	4335	COLORECTAL	-	-	-	1	MET	uc011knh.1,p.E240A|uc011kng.1,p.E240A|uc011knb.1,p.E240A|uc003vij.3,p.E240A|NM_000245,p.E240A|NM_001127500,p.E240A|uc011knf.2,p.E240A|uc010lkh.3,p.E240A|ENST00000397752,p.E240A|uc010lkg.3,p.E240A|uc011kna.1,p.E240A|uc011kmz.1,p.E240A|uc022akk.1,p.E240A|uc011knc.1,p.E240A|uc003vii.1,p.E259A|uc011kni.2,p.E240A|uc011knd.2,p.E240A|uc011kne.2,p.E240A|ENST00000318493,p.E240A|ENST00000436117,p.E240A	protein_coding, processed_transcript	uc022akk.1	nonsynonymous SNV	exon2	c.A719C	p.E240A	FLTDQSYIDVLPEFRDSYPIKYVHA	FLTDQSYIDVLPAFRDSYPIKYVHA	9.0	6.0	-	-	4335_7:116339857-116339857 A>C_FLTDQSYIDVLPAFRDSYPIKYVHA	0.0
1:46489651-46489651 A>C	1.0	4252	COLORECTAL	-	-	-	-	MAST2	uc001cov.3,p.E593D|uc001cow.3,p.E593D|ENST00000361297,p.E593D|NM_015112,p.E593D|ENST00000372009,p.E523D|ENST00000372008,p.E478D|uc001coy.1,p.E267D|uc001coz.1,p.E478D	protein_coding, processed_transcript	uc001coz.1	nonsynonymous SNV	exon13	c.A1434C	p.E478D	TKRHLCMVMEYVEGGDCATLLKNIG	TKRHLCMVMEYVDGGDCATLLKNIG	8.0	8.0	-	-	4252_1:46489651-46489651 A>C_TKRHLCMVMEYVDGGDCATLLKNIG	0.0
15:101862765-101862765 C>A	0.0	4335	COLORECTAL	-	-	-	-	PCSK6	uc010bpd.3,p.D605Y|ENST00000348070,p.D808Y|ENST00000398185,p.D637Y|ENST00000358417,p.D795Y	retained_intron, protein_coding, processed_transcript	uc010bpd.3	nonsynonymous SNV	exon15	c.G1813T	p.D605Y	CLKCHPSCKKCVDEPEKCTVCKEGF	CLKCHPSCKKCVYEPEKCTVCKEGF	6.0	8.0	-	-	4335_15:101862765-101862765 C>A_CLKCHPSCKKCVYEPEKCTVCKEGF	0.0
2:96690199-96690199 C>T	0.0	4149	OVARIAN	-	-	-	-	GPAT2	uc002svg.3,p.V428I|uc002svd.3,p.V368I|ENST00000434632,p.V549I|ENST00000359548,p.V549I|uc002svh.3,p.V549I|NM_207328,p.V549I|uc010yuh.2,p.V478I|uc002sve.3,p.V351I|uc002svf.3,p.V549I|ENST00000377137,p.V549I|ENST00000453542,p.V478I	retained_intron, protein_coding, processed_transcript	uc010yuh.2	nonsynonymous SNV	exon14	c.G1432A	p.V478I	THLAQLSAELLPVFLSEAVGACAVR	THLAQLSAELLPIFLSEAVGACAVR	5.0	3.0	-	-	4149_2:96690199-96690199 C>T_THLAQLSAELLPIFLSEAVGACAVR	0.0
5:74807152-74807152 ->G	0.0	4335	COLORECTAL	-	-	-	-	COL4A3BP	uc003kdt.3,p.T89fs|NM_001130105,p.T89fs|ENST00000380494,p.T89fs	protein_coding, processed_transcript	uc003kdt.3	frameshift insertion	exon2	c.264dupC	p.T89fs	GGRTSSLLLLPPTPERALFASPSPD	GGRTSSLLLLPPHTGAGTLRFAIPRPFTPRTGRLLRRS	7.0	8.0	-	-	4335_5:74807152-74807152 ->G_GGRTSSLLLLPPHTGAGTLRFAIPRPFTPRTGRLLRRS	0.0
11:6129367-6129367 T>C	0.0	4186	BREAST	-	-	-	-	OR56B4	NM_001005181,p.I120T|uc010qzx.2,p.I120T|ENST00000316529,p.I120T	protein_coding	uc010qzx.2	nonsynonymous SNV	exon1	c.T359C	p.I120T	YAIHCFFCIESGIFLCMAVDRYIAI	YAIHCFFCIESGTFLCMAVDRYIAI	1.0	7.0	-	-	4186_11:6129367-6129367 T>C_YAIHCFFCIESGTFLCMAVDRYIAI	0.0
7:18630033-18630033 G>C	0.0	4235	COLORECTAL	-	-	-	-	HDAC9	uc003sue.3,p.R110S|ENST00000406451,p.R110S|uc011jya.2,p.R152S|NM_001204146,p.R113S|ENST00000432645,p.R110S|NM_001204148,p.R82S|uc003sud.2,p.R110S|ENST00000428307,p.R110S|NM_178423,p.R110S|uc011jyf.2,p.R79S|ENST00000441986,p.R79S|NM_001204145,p.R110S|ENST00000406072,p.R141S|uc011jyc.2,p.R113S|uc011jye.2,p.R82S|uc003suh.3,p.R110S|ENST00000413509,p.R113S|uc010kud.2,p.R113S|NM_178425,p.R113S|ENST00000417496,p.R152S|uc003sua.1,p.R132S|uc011jyd.2,p.R110S|ENST00000413380,p.R113S|ENST00000405010,p.R110S|NM_001204147,p.R79S|uc003sui.3,p.R113S|uc011jyb.2,p.R110S|uc003suj.3,p.R113S|ENST00000401921,p.R113S|ENST00000524023,p.R79S|ENST00000456174,p.R82S|NM_058176,p.R110S|ENST00000441542,p.R113S|NM_014707,p.R110S|uc003suf.2,p.R141S|NM_001204144,p.R152S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jyf.2	nonsynonymous SNV	exon3	c.G237C	p.R79S	ELLEKEQKLEQQRQEQEVERHRREQ	ELLEKEQKLEQQSQEQEVERHRREQ	6.0	5.0	-	-	4235_7:18630033-18630033 G>C_ELLEKEQKLEQQSQEQEVERHRREQ	0.0
17:42978470-42978470 G>T	1.0	4326	BREAST	-	-	-	-	CCDC103	ENST00000357776,p.R35L|NM_213607,p.R35L|NM_001258399,p.R35L|NM_001258395,p.R35L|ENST00000410027,p.R35L|uc031rba.1,p.R35L|uc002iho.4,p.R35L|NM_001258398,p.R35L|NM_001258396,p.R35L|ENST00000417826,p.R35L|uc031ray.1,p.R35L|NM_001258397,p.R35L|ENST00000577339,p.R35L|ENST00000410006,p.R35L|uc031raz.1,p.R35L|uc031rax.1,p.R35L|uc031raw.1,p.R35L	protein_coding	uc031rba.1	nonsynonymous SNV	exon2	c.G104T	p.R35L	DEKYKRENAAKLRAVEQRVASYEEF	DEKYKRENAAKLLAVEQRVASYEEF	4.0	10.0	-	-	4326_17:42978470-42978470 G>T_DEKYKRENAAKLLAVEQRVASYEEF	0.0
18:19153729-19153729 T>C	1.0	4281	COLORECTAL	-	-	-	-	ESCO1	ENST00000269214,p.D359G|NM_052911,p.D359G|ENST00000383276,p.D359G|uc002kth.1,p.D359G	protein_coding, processed_transcript, nonsense_mediated_decay	uc002kth.1	nonsynonymous SNV	exon4	c.A1076G	p.D359G	ERQILHQKETNQDVQCNRFFPSRKT	ERQILHQKETNQGVQCNRFFPSRKT	6.0	4.0	-	-	4281_18:19153729-19153729 T>C_ERQILHQKETNQGVQCNRFFPSRKT	0.0
1:162302895-162302895 G>A	1.0	4196	COLORECTAL	-	-	ID=COSM1290024,COSM1290025;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	NOS1AP	uc010pkr.1,p.V140I|ENST00000530878,p.V140I|uc001gbv.2,p.V145I|NM_014697,p.V145I|NM_001164757,p.V140I|ENST00000361897,p.V145I|uc001gbw.2,p.V140I|ENST00000430120,p.V140I	protein_coding, processed_transcript, nonsense_mediated_decay	uc010pkr.1	nonsynonymous SNV	exon5	c.G418A	p.V140I	ARDGASNIFRCNVFKSKKKSQAMRI	ARDGASNIFRCNIFKSKKKSQAMRI	8.0	6.0	-	-	4196_1:162302895-162302895 G>A_ARDGASNIFRCNIFKSKKKSQAMRI	0.0
15:79296188-79296188 G>A	0.0	4275	COLORECTAL	0.0027	-	-	-	RASGRF1	NM_001145648,p.T802M|ENST00000419573,p.T818M|ENST00000394745,p.T34M|uc002beo.3,p.T34M|uc002ber.4,p.T802M|uc002beq.3,p.T818M|NM_002891,p.T818M|uc002bep.3,p.T802M|uc010blm.1,p.T727M|uc010unh.1,p.T213M|ENST00000558480,p.T802M|NM_153815,p.T34M	retained_intron, protein_coding, processed_transcript, TEC	uc010unh.1	nonsynonymous SNV	exon4	c.C638T	p.T213M	SSFTNKIPDEGDTTPEKPEDPSALS	SSFTNKIPDEGDMTPEKPEDPSALS	5.0	2.0	-	-	4275_15:79296188-79296188 G>A_SSFTNKIPDEGDMTPEKPEDPSALS	0.0
11:89531533-89531533 G>T	0.0	4275	COLORECTAL	-	rs146898780	-	-	TRIM49	NM_020358,p.A375E|ENST00000329758,p.A375E|ENST00000532501,p.A298E|uc001pdb.3,p.A375E	protein_coding	uc001pdb.3	nonsynonymous SNV	exon8	c.C1124A	p.A375E	KEKNQNEKIDGKAGLFLLGCVKNDI	KEKNQNEKIDGKEGLFLLGCVKNDI	1.0	1.0	-	-	4275_11:89531533-89531533 G>T_KEKNQNEKIDGKEGLFLLGCVKNDI	0.0
15:88472414-88472414 C>A	0.0	4301	MELANOMA	-	-	-	1	NTRK3	uc010bnh.1,p.X706L|ENST00000558676,p.X706L	protein_coding, processed_transcript	uc010bnh.1	stoploss	exon14	c.G2117T	p.X706L	RDVYSTDYYRVK	RDVYSTDYYRVKLLSQLQDSATELAPCLHVFFIVH	6.0	7.0	-	translated beyond stop codon This mutation type can not produce mer (stoploss,p.X706L,c.G2117T,uc010bnh.1) PR	4301_15:88472414-88472414 C>A_RDVYSTDYYRVKLLSQLQDSATELAPCLHVFFIVH	0.0
X:74644535-74644535 G>C	0.0	4287	COLORECTAL	-	-	-	-	ZDHHC15	uc004ecg.3,p.L230V|NM_001146256,p.L221V|NM_144969,p.L230V|ENST00000373367,p.L230V|ENST00000541184,p.L221V|uc004ech.3,p.L221V	protein_coding, processed_transcript	uc004ech.3	nonsynonymous SNV	exon7	c.C661G	p.L221V	FVACMFFVSLVILFGYHCWLVSRNK	FVACMFFVSLVIVFGYHCWLVSRNK	4.0	8.0	-	-	4287_X:74644535-74644535 G>C_FVACMFFVSLVIVFGYHCWLVSRNK	0.0
1:234454623-234454623 G>A	0.0	3795	MELANOMA	-	-	-	-	SLC35F3	NM_173508,p.E361K|NM_001300845,p.E292K|ENST00000366618,p.E361K|uc001hvy.1,p.E361K|ENST00000366617,p.E292K|uc001hwa.1,p.E292K	protein_coding	uc001hwa.1	nonsynonymous SNV	exon5	c.G874A	p.E292K	TCIPIILYFTKVEYWSSFDDIPWGN	TCIPIILYFTKVKYWSSFDDIPWGN	3.0	8.0	-	-	3795_1:234454623-234454623 G>A_TCIPIILYFTKVKYWSSFDDIPWGN	0.0
1:248308963-248308963 C>T	0.0	4081	COLORECTAL	-	-	ID=COSM267072;OCCURENCE=2(NS),1(endometrium),1(large_intestine)	-	OR2M5	uc010pze.2,p.R172W|NM_001004690,p.R172W|ENST00000366476,p.R172W	protein_coding	uc010pze.2	nonsynonymous SNV	exon1	c.C514T	p.R172W	AVATFSFSYCGSREIAHFFCDFPSL	AVATFSFSYCGSWEIAHFFCDFPSL	1.0	10.0	-	-	4081_1:248308963-248308963 C>T_AVATFSFSYCGSWEIAHFFCDFPSL	0.0
3:173996843-173996843 G>A	1.0	2556	MELANOMA	-	-	-	-	NLGN1	uc003fio.1,p.R351Q|uc010hww.1,p.R391Q|ENST00000545397,p.R351Q|ENST00000457714,p.R351Q|ENST00000401917,p.R391Q|ENST00000361589,p.R351Q|uc003fip.1,p.R351Q|NM_014932,p.R351Q|uc021xhm.1,p.R391Q	protein_coding, processed_transcript	uc021xhm.1	nonsynonymous SNV	exon6	c.G1172A	p.R391Q	YKELVDQDIQPARYHIAFGPVIDGD	YKELVDQDIQPAQYHIAFGPVIDGD	9.0	2.0	-	-	2556_3:173996843-173996843 G>A_YKELVDQDIQPAQYHIAFGPVIDGD	0.0
2:219544686-219544686 C>T	1.0	3713	MELANOMA	-	-	-	-	STK36	ENST00000392106,p.P340L|ENST00000392105,p.P340L|NM_015690,p.P340L|ENST00000440309,p.P340L|NM_001243313,p.P340L|uc002viv.3,p.P340L|uc002viu.3,p.P340L|ENST00000295709,p.P340L	retained_intron, protein_coding, nonsense_mediated_decay	uc002viv.3	nonsynonymous SNV	exon9	c.C1019T	p.P340L	EDKTSKVAPGTAPLPRLGATPQESS	EDKTSKVAPGTALLPRLGATPQESS	9.0	5.0	-	-	3713_2:219544686-219544686 C>T_EDKTSKVAPGTALLPRLGATPQESS	0.0
2:192255065-192255065 C>T	1.0	3466	MELANOMA	-	-	-	-	MYO1B	NM_012223,p.A610V|ENST00000392316,p.A610V|uc002usq.2,p.A610V|ENST00000304164,p.A610V|NM_001161819,p.A610V|NM_001130158,p.A610V|uc010fsg.2,p.A610V|ENST00000392318,p.A610V|ENST00000339514,p.A610V|uc002usr.2,p.A610V	retained_intron, protein_coding, processed_transcript	uc010fsg.2	nonsynonymous SNV	exon18	c.C1829T	p.A610V	PNDKKAAHIFNEALVCHQIRYLGLL	PNDKKAAHIFNEVLVCHQIRYLGLL	8.0	8.0	-	-	3466_2:192255065-192255065 C>T_PNDKKAAHIFNEVLVCHQIRYLGLL	0.0
1:240371764-240371764 C>T	0.0	4301	MELANOMA	-	-	-	-	FMN2	uc010pye.2,p.P1222S|ENST00000319653,p.P1218S|uc010pyd.2,p.P1218S|NM_020066,p.P1218S	protein_coding, processed_transcript	uc010pye.2	nonsynonymous SNV	exon6	c.C3664T	p.P1222S	IPPPPPLPGMGIPPAPAPPLPPPGT	IPPPPPLPGMGISPAPAPPLPPPGT	3.0	5.0	-	-	4301_1:240371764-240371764 C>T_IPPPPPLPGMGISPAPAPPLPPPGT	0.0
19:44933932-44933932 C>T	1.0	2369	MELANOMA	-	-	-	-	ZNF229	uc010ejl.1,p.A336T|uc002oze.1,p.A342T|ENST00000291187,p.A336T|NM_001278510,p.A336T|NM_014518,p.A342T|ENST00000588931,p.A342T	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ejl.1	nonsynonymous SNV	exon6	c.G1006A	p.A336T	VRQNTHIRNHPRAPVGDMPYRCDVC	VRQNTHIRNHPRTPVGDMPYRCDVC	5.0	7.0	-	-	2369_19:44933932-44933932 C>T_VRQNTHIRNHPRTPVGDMPYRCDVC	0.0
2:103095694-103095694 C>A	0.0	4298	COLORECTAL	-	-	-	-	SLC9A4	uc002tbz.4,p.A218E|ENST00000295269,p.A218E|NM_001011552,p.A218E	retained_intron, protein_coding	uc002tbz.4	nonsynonymous SNV	exon2	c.C653A	p.A218E	VDPVAVLAVFEEARVNEQLYMMIFG	VDPVAVLAVFEEERVNEQLYMMIFG	2.0	7.0	-	-	4298_2:103095694-103095694 C>A_VDPVAVLAVFEEERVNEQLYMMIFG	0.0
3:158983149-158983149 A>C	0.0	4158	COLORECTAL	-	-	-	-	IQCJ	ENST00000451172,p.K146T|uc010hvy.2,p.K119T|NM_001197100,p.K119T|NM_001042705,p.K146T|uc003fcp.2,p.K146T|ENST00000482126,p.K119T	protein_coding, processed_transcript	uc010hvy.2	nonsynonymous SNV	exon4	c.A356C	p.K119T	QLARPTGFIHTLKEPQIERLGFLTL	QLARPTGFIHTLTEPQIERLGFLTL	2.0	5.0	-	-	4158_3:158983149-158983149 A>C_QLARPTGFIHTLTEPQIERLGFLTL	0.0
19:50861863-50861863 G>A	0.0	4240	BREAST	-	-	ID=COSM382111;OCCURENCE=1(lung)	-	NAPSA	ENST00000253719,p.R404C|NM_004851,p.R404C|uc002prx.3,p.R404C	retained_intron, protein_coding, nonsense_mediated_decay	uc002prx.3	nonsynonymous SNV	exon9	c.C1210T	p.R404C	SSARVGLARARTRGADLGWGETAQA	SSARVGLARARTCGADLGWGETAQA	3.0	8.0	-	-	4240_19:50861863-50861863 G>A_SSARVGLARARTCGADLGWGETAQA	0.0
10:50669473-50669473 C>T	1.0	4258	ENDOMETRIAL	-	-	-	-	ERCC6	NM_000124,p.R1303Q|uc001jhr.5,p.R671Q|uc010qgr.3,p.R673Q|uc009xod.4,p.R463Q|ENST00000542458,p.R673Q|ENST00000355832,p.R1303Q|uc001jhs.5,p.R1303Q	protein_coding, processed_transcript	uc010qgr.3	nonsynonymous SNV	exon13	c.G2018A	p.R673Q	QDALKALRLSRQRCLGAVSGVPTWT	QDALKALRLSRQQCLGAVSGVPTWT	6.0	9.0	-	-	4258_10:50669473-50669473 C>T_QDALKALRLSRQQCLGAVSGVPTWT	0.0
14:94707109-94707109 G>A	1.0	2369	MELANOMA	-	-	-	-	PPP4R4	uc001ycs.1,p.G318E|ENST00000304338,p.G318E|NM_058237,p.G318E	protein_coding, processed_transcript	uc001ycs.1	nonsynonymous SNV	exon9	c.G953A	p.G318E	DESILISLSFHLGKLCHGLYGIFTP	DESILISLSFHLEKLCHGLYGIFTP	4.0	8.0	-	-	2369_14:94707109-94707109 G>A_DESILISLSFHLEKLCHGLYGIFTP	0.0
1:2700215-2700215 G>A	0.0	4266	COLORECTAL	0.0032	-	-	-	TTC34	uc021oey.1,p.P209L|ENST00000401095,p.P209L|NM_001242672,p.P209L	retained_intron, protein_coding	uc021oey.1	nonsynonymous SNV	exon4	c.C626T	p.P209L	AMFDFNTVLRAEPGNVQALCGRALV	AMFDFNTVLRAELGNVQALCGRALV	2.0	2.0	-	-	4266_1:2700215-2700215 G>A_AMFDFNTVLRAELGNVQALCGRALV	0.0
17:45199928-45199928 C>T	1.0	3678	MELANOMA	-	-	-	-	CDC27	ENST00000527547,p.M757I|ENST00000446365,p.M697I|uc002ild.4,p.M758I|ENST00000066544,p.M758I|NM_001293091,p.M697I|NM_001114091,p.M764I|NM_001293089,p.M757I|NM_001256,p.M758I|ENST00000531206,p.M764I|uc010wkp.2,p.M697I|uc002ile.4,p.M764I|uc002ilf.4,p.M757I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wkp.2	nonsynonymous SNV	exon17	c.G2091A	p.M697I	VYKKLGQTHLALMNFSWAMDLDPKG	VYKKLGQTHLALINFSWAMDLDPKG	9.0	8.0	-	-	3678_17:45199928-45199928 C>T_VYKKLGQTHLALINFSWAMDLDPKG	0.0
6:66115128-66115128 T>C	0.0	4213	COLORECTAL	-	-	-	-	EYS	uc021zbn.1,p.D332G|uc011dxu.1,p.D332G|NM_198283,p.D332G|ENST00000503581,p.D332G|ENST00000370621,p.D332G|ENST00000393380,p.D332G|NM_001142801,p.D332G|uc003per.1,p.D332G|ENST00000342421,p.D332G|NM_001142800,p.D332G|uc003peq.3,p.D332G|NM_001292009,p.D332G|ENST00000370616,p.D332G|ENST00000370618,p.D332G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zbn.1	nonsynonymous SNV	exon6	c.A995G	p.D332G	CPKGSSSQNGETDVSEFSLVPCQNG	CPKGSSSQNGETGVSEFSLVPCQNG	4.0	5.0	-	-	4213_6:66115128-66115128 T>C_CPKGSSSQNGETGVSEFSLVPCQNG	0.0
14:39796122-39796122 A>T	0.0	4149	OVARIAN	-	-	-	-	CTAGE5	ENST00000396158,p.E581V|uc010amz.3,p.E192V|uc001wva.4,p.E547V|NM_005930,p.E576V|ENST00000348007,p.E533V|ENST00000556148,p.E501V|uc001wvh.4,p.E533V|NM_203354,p.E564V|ENST00000280083,p.E576V|ENST00000553728,p.E1111V|ENST00000341749,p.E564V|ENST00000341502,p.E576V|uc001wuy.4,p.E496V|NM_203355,p.E533V|uc001wvc.4,p.E478V|NM_001247988,p.E504V|uc001wvg.4,p.E576V|ENST00000396165,p.E547V|ENST00000603904,p.E547V|uc001wvb.4,p.E504V|NM_203356,p.E547V|uc001wvj.4,p.E547V|uc001wvf.4,p.E501V|uc001wvi.4,p.E581V|uc001wuz.4,p.E564V|ENST00000557038,p.E496V|uc010tqe.1,p.E538V|ENST00000553352,p.E547V|NM_001247989,p.E581V|NM_001247990,p.E501V	protein_coding, processed_transcript	uc010tqe.1	nonsynonymous SNV	exon19	c.A1613T	p.E538V	NPLDHQITNERGESSCDRLTDPHRA	NPLDHQITNERGVSSCDRLTDPHRA	8.0	8.0	-	-	4149_14:39796122-39796122 A>T_NPLDHQITNERGVSSCDRLTDPHRA	0.0
17:73814834-73814834 C>T	1.0	3713	MELANOMA	-	-	-	-	UNK	ENST00000589666,p.P495S|uc021udd.2,p.P495S|NM_001080419,p.P495S|ENST00000293218,p.P571S	retained_intron, protein_coding, nonsense_mediated_decay	uc021udd.2	nonsynonymous SNV	exon11	c.C1483T	p.P495S	ATPPSPVGTSSVPGMNANALPFYPT	ATPPSPVGTSSVSGMNANALPFYPT	8.0	7.0	-	-	3713_17:73814834-73814834 C>T_ATPPSPVGTSSVSGMNANALPFYPT	0.0
2:86360313-86360313 C>A	1.0	4189	MELANOMA	-	-	-	-	PTCD3	uc002sqw.2,p.F462L|uc002sqx.1,p.F52L|ENST00000254630,p.F462L|NM_017952,p.F462L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002sqx.1	nonsynonymous SNV	exon8	c.C156A	p.F52L	PDQHRNFYYSKFFDLICLMEQIDVT	PDQHRNFYYSKFLDLICLMEQIDVT	10.0	7.0	-	-	4189_2:86360313-86360313 C>A_PDQHRNFYYSKFLDLICLMEQIDVT	0.0
19:3382043-3382043 C>T	1.0	3998	MELANOMA	-	-	-	-	NFIC	uc010xhj.2,p.R122W|NM_001245004,p.R122W|ENST00000589123,p.R113W|ENST00000346156,p.R113W|NM_005597,p.R122W|ENST00000443272,p.R122W|ENST00000395111,p.R113W|ENST00000590282,p.R122W|uc002lxo.3,p.R113W|ENST00000586919,p.R113W|NM_001245002,p.R122W|uc010xhh.2,p.R113W|ENST00000341919,p.R122W|NM_205843,p.R113W|NM_001245005,p.R113W|uc010xhi.2,p.R122W|uc002lxp.3,p.R122W	retained_intron, protein_coding, processed_transcript	uc010xhj.2	nonsynonymous SNV	exon2	c.C364T	p.R122W	DQKGKMRRIDCLRQADKVWRLDLVM	DQKGKMRRIDCLWQADKVWRLDLVM	9.0	8.0	-	-	3998_19:3382043-3382043 C>T_DQKGKMRRIDCLWQADKVWRLDLVM	0.0
11:40137302-40137302 C>T	0.0	3795	MELANOMA	-	-	-	-	LRRC4C	uc031pzu.1,p.E181K|uc031pzt.1,p.E181K|ENST00000528697,p.E181K|ENST00000527150,p.E181K|ENST00000278198,p.E181K|uc001mxb.2,p.E177K|ENST00000530763,p.E181K|uc031pzs.1,p.E177K|NM_020929,p.E181K|NM_001258419,p.E181K|uc021qgf.1,p.E181K	protein_coding, processed_transcript	uc031pzu.1	nonsynonymous SNV	exon5	c.G541A	p.E181K	NRIPSLRRLDLGELKRLSYISEGAF	NRIPSLRRLDLGKLKRLSYISEGAF	1.0	10.0	-	-	3795_11:40137302-40137302 C>T_NRIPSLRRLDLGKLKRLSYISEGAF	0.0
19:38014348-38014348 G>A	0.0	4081	COLORECTAL	0	-	-	-	ZNF793	ENST00000542455,p.E3K|ENST00000588578,p.E3K|NM_001013659,p.E3K|uc010xts.2,p.E3K|ENST00000587986,p.E3K|uc031rkk.1,p.E3K|uc010efm.3,p.E3K|ENST00000586138,p.E3K|ENST00000589319,p.E3K|ENST00000587143,p.E3K|ENST00000445217,p.E3K	protein_coding, nonsense_mediated_decay	uc031rkk.1	nonsynonymous SNV	exon5	c.G7A	p.E3K	MIEYQIPVSFKDVVV	MIKYQIPVSFKDVVV	3.0	10.0	-	-	4081_19:38014348-38014348 G>A_MIKYQIPVSFKDVVV	0.0
7:76912006-76912006 G>A	1.0	4252	COLORECTAL	-	-	-	-	CCDC146	uc010ldp.3,p.M398I|ENST00000431197,p.M398I|uc003uga.3,p.M684I|ENST00000285871,p.M684I|uc003ugc.3,p.M21I|NM_020879,p.M684I	retained_intron, protein_coding, processed_transcript	uc010ldp.3	nonsynonymous SNV	exon7	c.G1194A	p.M398I	IHLLEEKIQFLKMKIAEKQRQICVT	IHLLEEKIQFLKIKIAEKQRQICVT	7.0	6.0	-	-	4252_7:76912006-76912006 G>A_IHLLEEKIQFLKIKIAEKQRQICVT	0.0
1:41948255-41948255 T>A	1.0	4326	BREAST	-	-	-	-	EDN2	NM_001956,p.T76S|ENST00000372587,p.T76S|uc001cgx.3,p.T76S	protein_coding, processed_transcript	uc001cgx.3	nonsynonymous SNV	exon3	c.A226T	p.T76S	HLDIIWVNTPEQTAPYGLGNPPRRR	HLDIIWVNTPEQSAPYGLGNPPRRR	8.0	5.0	-	-	4326_1:41948255-41948255 T>A_HLDIIWVNTPEQSAPYGLGNPPRRR	0.0
5:140554097-140554097 G>A	1.0	4237	NSCLC	-	-	ID=COSM1434237;OCCURENCE=1(large_intestine)	-	PCDHB7	ENST00000231137,p.V561M|uc003lit.3,p.V561M|NM_018940,p.V561M	protein_coding	uc003lit.3	nonsynonymous SNV	exon1	c.G1681A	p.V561M	VLVLDANDNSPFVLYPLQNSSAPCT	VLVLDANDNSPFMLYPLQNSSAPCT	6.0	7.0	-	-	4237_5:140554097-140554097 G>A_VLVLDANDNSPFMLYPLQNSSAPCT	0.0
8:143957809-143957809 C>T	0.0	4275	COLORECTAL	-	-	-	-	CYP11B1	NM_001026213,p.D268N|ENST00000292427,p.D268N|uc003yxi.3,p.D268N|ENST00000377675,p.D339N|uc010mey.3,p.D339N|ENST00000517471,p.D268N|uc003yxj.3,p.D268N|NM_000497,p.D268N	retained_intron, protein_coding	uc010mey.3	nonsynonymous SNV	exon7	c.G1015A	p.D339N	HFEAWDCIFQYGDNCIQKIYQELAF	HFEAWDCIFQYGNNCIQKIYQELAF	1.0	3.0	-	-	4275_8:143957809-143957809 C>T_HFEAWDCIFQYGNNCIQKIYQELAF	0.0
1:162773300-162773300 C>T	1.0	4329	COLORECTAL	-	-	-	-	HSD17B7	NM_016371,p.T241M|uc001gci.3,p.T241M|ENST00000254521,p.T241M	protein_coding, processed_transcript, nonsense_mediated_decay	uc001gci.3	nonsynonymous SNV	exon6	c.C722T	p.T241M	NLTYGILPPFIWTLLMPAILLLRFF	NLTYGILPPFIWMLLMPAILLLRFF	9.0	8.0	-	-	4329_1:162773300-162773300 C>T_NLTYGILPPFIWMLLMPAILLLRFF	0.0
7:121960313-121960313 C>T	1.0	4136	BREAST	-	-	ID=COSM3411530,COSM3411529;OCCURENCE=1(central_nervous_system)	-	CADPS2	ENST00000412584,p.R1225H|uc010lkq.3,p.R1225H|uc022akr.1,p.R1266H|ENST00000449022,p.R1266H|ENST00000313070,p.R1225H|uc003vkg.4,p.R920H|NM_001167940,p.R1270H|NM_001009571,p.R1225H|NM_017954,p.R1266H|ENST00000334010,p.R1264H	protein_coding, processed_transcript	uc022akr.1	nonsynonymous SNV	exon30	c.G3797A	p.R1266H	TLNSKTYDTVHRRLTVEEATASVSE	TLNSKTYDTVHRHLTVEEATASVSE	8.0	8.0	CD8	-	4136_7:121960313-121960313 C>T_TLNSKTYDTVHRHLTVEEATASVSE	1.0
4:57220918-57220918 T>C	0.0	4335	COLORECTAL	-	-	-	-	AASDH	uc003hbn.3,p.D388G|ENST00000513376,p.D288G|NM_181806,p.D388G|uc003hbo.3,p.D288G|uc010ihc.3,p.D388G|uc003hbp.3,p.D388G|NM_001286671,p.D388G|NM_001286669,p.D235G|uc011caa.2,p.D235G|ENST00000451613,p.D388G|NM_001286672,p.D388G|NM_001286668,p.D288G|ENST00000602986,p.D235G|ENST00000205214,p.D388G|ENST00000502617,p.D388G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011caa.2	nonsynonymous SNV	exon6	c.A704G	p.D235G	GFPLLGTVVEVRDTNGFTIQEGSGQ	GFPLLGTVVEVRGTNGFTIQEGSGQ	7.0	8.0	-	-	4335_4:57220918-57220918 T>C_GFPLLGTVVEVRGTNGFTIQEGSGQ	0.0
3:48697646-48697646 C>A	1.0	4287	COLORECTAL	-	-	-	-	CELSR3	NM_001407,p.G808W|ENST00000164024,p.G808W|uc003cul.3,p.G808W|ENST00000544264,p.G808W|uc003cuf.1,p.G878W	retained_intron, protein_coding	uc003cul.3	nonsynonymous SNV	exon1	c.G2422T	p.G808W	GNTRNRFAISTQGGVGLVTLALPLD	GNTRNRFAISTQWGVGLVTLALPLD	3.0	10.0	-	-	4287_3:48697646-48697646 C>A_GNTRNRFAISTQWGVGLVTLALPLD	0.0
15:32460449-32460449 G>T	0.0	4316	COLORECTAL	-	-	-	-	CHRNA7	NM_000746,p.L433F|uc010bak.3,p.L348F|uc001zft.4,p.L433F|ENST00000455693,p.L252F|uc021sic.2,p.L462F|ENST00000306901,p.L433F|NM_001190455,p.L462F|ENST00000454250,p.L462F|uc010baf.4,p.L252F	protein_coding, nonsense_mediated_decay	uc021sic.2	nonsynonymous SNV	exon10	c.G1386T	p.L462F	LHGGQPPEGDPDLAKILEEVRYIAN	LHGGQPPEGDPDFAKILEEVRYIAN	2.0	5.0	-	-	4316_15:32460449-32460449 G>T_LHGGQPPEGDPDFAKILEEVRYIAN	0.0
7:82582687-82582687 C>T	0.0	4301	MELANOMA	-	-	-	-	PCLO	NM_033026,p.D2528N|uc003uhx.2,p.D2528N|uc003uhv.2,p.D2528N|ENST00000423517,p.D2528N|ENST00000333891,p.D2528N|NM_014510,p.D2528N	protein_coding, processed_transcript, nonsense_mediated_decay	uc003uhx.2	nonsynonymous SNV	exon5	c.G7582A	p.D2528N	IPQLPTTTQKPTDIHPKPTGLSLTS	IPQLPTTTQKPTNIHPKPTGLSLTS	4.0	10.0	-	-	4301_7:82582687-82582687 C>T_IPQLPTTTQKPTNIHPKPTGLSLTS	0.0
12:117426562-117426562 C>T	1.0	3879	MELANOMA	-	-	-	-	FBXW8	NM_012174,p.S310F|ENST00000309909,p.S376F|uc001twf.1,p.S310F|ENST00000455858,p.S310F|uc001twg.1,p.S376F|NM_153348,p.S376F	protein_coding, processed_transcript	uc001twg.1	nonsynonymous SNV	exon7	c.C1127T	p.S376F	AGDLMYLLKAEDSARTLLYAHGPPV	AGDLMYLLKAEDFARTLLYAHGPPV	7.0	6.0	-	-	3879_12:117426562-117426562 C>T_AGDLMYLLKAEDFARTLLYAHGPPV	0.0
X:88008772-88008772 G>A	0.0	4326	BREAST	-	-	-	-	CPXCR1	uc022bzq.1,p.M119I|uc004efd.4,p.M119I|NM_033048,p.M119I|ENST00000276127,p.M119I|NM_001184771,p.M119I|ENST00000373111,p.M119I|uc004efc.4,p.M119I	protein_coding	uc022bzq.1	nonsynonymous SNV	exon1	c.G357A	p.M119I	NDRSRSHSGKVEMKANNFPINHKTR	NDRSRSHSGKVEIKANNFPINHKTR	1.0	4.0	-	-	4326_X:88008772-88008772 G>A_NDRSRSHSGKVEIKANNFPINHKTR	0.0
12:113545997-113545997 G>C	1.0	3775	CERVICAL	-	-	-	-	RASAL1	NM_004658,p.L469V|uc001tuo.4,p.L469V|uc001tum.2,p.L469V|uc010syq.2,p.L469V|ENST00000261729,p.L469V|uc001tul.3,p.L469V|uc010syr.2,p.L469V|NM_001193521,p.L469V|NM_001301202,p.L469V|ENST00000446861,p.L469V|uc010syp.2,p.L469V|ENST00000548055,p.L469V	retained_intron, protein_coding, processed_transcript	uc010syr.2	nonsynonymous SNV	exon14	c.C1405G	p.L469V	HQDVKYLAISGFLFLRFFAPAILTP	HQDVKYLAISGFVFLRFFAPAILTP	5.0	10.0	-	-	3775_12:113545997-113545997 G>C_HQDVKYLAISGFVFLRFFAPAILTP	0.0
1:158590071-158590071 C>A	0.0	4259	COLORECTAL	-	-	-	-	SPTA1	ENST00000368148,p.L2102F|uc001fst.1,p.L2102F|ENST00000368147,p.L2099F|NM_003126,p.L2102F	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon44	c.G6306T	p.L2102F	ASLARAQADFKCLLELDQQIKALGV	ASLARAQADFKCFLELDQQIKALGV	2.0	8.0	-	-	4259_1:158590071-158590071 C>A_ASLARAQADFKCFLELDQQIKALGV	0.0
16:66998347-66998347 C>A	0.0	4240	BREAST	-	-	-	-	CES3	ENST00000570236,p.F216L|NM_001185177,p.F216L|ENST00000394037,p.F216L|NM_024922,p.F216L|uc002eqt.3,p.F216L|ENST00000303334,p.F216L|uc010cdz.3,p.F216L	retained_intron, protein_coding, nonsense_mediated_decay	uc010cdz.3	nonsynonymous SNV	exon5	c.C648A	p.F216L	AALRWVQENIAPFGGDLNCVTVFGG	AALRWVQENIAPLGGDLNCVTVFGG	3.0	8.0	-	-	4240_16:66998347-66998347 C>A_AALRWVQENIAPLGGDLNCVTVFGG	0.0
12:83526003-83526003 G>T	1.0	4129	NSCLC	-	-	-	-	TMTC2	NM_152588,p.L782F|ENST00000549919,p.L776F|uc010suk.2,p.L537F|ENST00000321196,p.L782F|uc001szt.3,p.L782F	retained_intron, protein_coding	uc010suk.2	nonsynonymous SNV	exon11	c.G1611T	p.L537F	LAARLRPNYPAALMNLGAILHLNGR	LAARLRPNYPAAFMNLGAILHLNGR	5.0	7.0	-	-	4129_12:83526003-83526003 G>T_LAARLRPNYPAAFMNLGAILHLNGR	0.0
X:154009994-154009994 A>T	0.0	4316	COLORECTAL	-	-	-	-	MPP1	ENST00000413259,p.S314T|NM_001166461,p.S324T|NM_001166462,p.S314T|ENST00000393531,p.S324T|uc011mzw.2,p.S327T|uc010nvg.2,p.S324T|uc004fmp.2,p.S344T|NM_001166460,p.S327T|NM_002436,p.S344T|uc011mzv.2,p.S314T|ENST00000369534,p.S344T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mzw.2	nonsynonymous SNV	exon10	c.T979A	p.S327T	HFISTEEMTRNISANEFLEFGSYQG	HFISTEEMTRNITANEFLEFGSYQG	5.0	7.0	-	-	4316_X:154009994-154009994 A>T_HFISTEEMTRNITANEFLEFGSYQG	0.0
1:32086678-32086678 C>T	0.0	4287	COLORECTAL	-	-	-	-	HCRTR1	ENST00000373706,p.R205C|uc001btd.2,p.R205C|ENST00000403528,p.R205C|NM_001525,p.R205C|uc001btc.4,p.R119C|uc010ogl.2,p.R205C|uc009vtx.2,p.R205C|ENST00000373705,p.R205C	protein_coding, processed_transcript	uc010ogl.2	nonsynonymous SNV	exon3	c.C613T	p.R205C	ANRTRLFSVCDERWADDLYPKIYHS	ANRTRLFSVCDECWADDLYPKIYHS	1.0	10.0	-	-	4287_1:32086678-32086678 C>T_ANRTRLFSVCDECWADDLYPKIYHS	0.0
2:189931462-189931462 C>T	1.0	3919	MELANOMA	-	-	ID=COSM1530199;OCCURENCE=1(lung)	-	COL5A2	uc002uqk.3,p.G483E|ENST00000374866,p.G483E|NM_000393,p.G483E	retained_intron, protein_coding	uc002uqk.3	nonsynonymous SNV	exon22	c.G1448A	p.G483E	GVPGFKGEAGPKGEPGPHGIQGPIG	GVPGFKGEAGPKEEPGPHGIQGPIG	5.0	1.0	-	-	3919_2:189931462-189931462 C>T_GVPGFKGEAGPKEEPGPHGIQGPIG	0.0
1:154961242-154961242 G>T	1.0	4240	BREAST	-	-	-	-	FLAD1	uc001fge.2,p.R248L|uc001fgc.3,p.R246L|NM_201398,p.R248L|ENST00000368432,p.R248L|uc001fgh.1,p.R78L|ENST00000368431,p.R246L|ENST00000315144,p.R248L|uc021paj.1,p.R246L|ENST00000295530,p.R78L|ENST00000292180,p.R345L|uc001fgg.2,p.R248L|NM_001184891,p.R248L|ENST00000405236,p.R246L|NM_025207,p.R345L|uc001fgf.2,p.R345L|NM_001184892,p.R246L|uc001fgd.2,p.R345L|ENST00000368433,p.R345L	protein_coding, processed_transcript	uc021paj.1	nonsynonymous SNV	exon1	c.G737T	p.R246L	GPLEECLAYLTARLPQGSLVPYMPN	GPLEECLAYLTALLPQGSLVPYMPN	10.0	9.0	-	-	4240_1:154961242-154961242 G>T_GPLEECLAYLTALLPQGSLVPYMPN	0.0
2:113943552-113943552 G>A	0.0	2591	MELANOMA	-	-	-	-	PSD4	uc002tje.3,p.E421K|ENST00000441564,p.E422K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tje.3	nonsynonymous SNV	exon5	c.G1261A	p.E421K	TLNSQDREPSSPESESRGPGPRPSP	TLNSQDREPSSPKSESRGPGPRPSP	3.0	2.0	-	-	2591_2:113943552-113943552 G>A_TLNSQDREPSSPKSESRGPGPRPSP	0.0
11:10622545-10622545 G>A	0.0	4245	COLORECTAL	-	-	-	-	MRVI1	ENST00000558540,p.T331M|ENST00000552103,p.T555M|uc009ygd.1,p.T331M|NM_130385,p.T646M|ENST00000547195,p.T555M|ENST00000534266,p.T331M|uc001mix.3,p.T331M|NM_001206880,p.T440M|uc010rcc.1,p.T646M|ENST00000527509,p.T555M|uc010rcb.1,p.T638M|uc010rcd.1,p.T440M|NM_001100167,p.T331M|NM_001098579,p.T638M|ENST00000545852,p.T331M|ENST00000531107,p.T638M|ENST00000423302,p.T646M|NM_001100163,p.T555M|ENST00000541483,p.T440M|NM_001206881,p.T331M|ENST00000424001,p.T331M|ENST00000526414,p.T389M|ENST00000436272,p.T619M|ENST00000421747,p.T637M|uc001miz.2,p.T555M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rcd.1	nonsynonymous SNV	exon14	c.C1319T	p.T440M	EVMMQYVENLKRTYEKDHAELMEFK	EVMMQYVENLKRMYEKDHAELMEFK	6.0	8.0	-	-	4245_11:10622545-10622545 G>A_EVMMQYVENLKRMYEKDHAELMEFK	0.0
13:53035634-53035634 G>A	1.0	3713	MELANOMA	-	-	-	-	CKAP2	uc001vgt.2,p.V225I|NM_001286686,p.V177I|ENST00000378034,p.V225I|NM_018204,p.V225I|ENST00000490903,p.V177I|ENST00000378037,p.V226I|uc001vgu.2,p.V225I|NM_001286687,p.V225I|NM_001098525,p.V226I|uc010tha.1,p.V177I|uc001vgv.2,p.V226I|ENST00000258607,p.V225I	retained_intron, protein_coding	uc010tha.1	nonsynonymous SNV	exon4	c.G529A	p.V177I	KATKPQPVNTSSVTVKSNRSSNMTA	KATKPQPVNTSSITVKSNRSSNMTA	7.0	7.0	-	-	3713_13:53035634-53035634 G>A_KATKPQPVNTSSITVKSNRSSNMTA	0.0
2:72968569-72968569 C>T	1.0	4278	COLORECTAL	0	-	-	-	EXOC6B	uc002sij.2,p.R48H|uc010fep.3,p.R48H|ENST00000410104,p.R48H|NM_015189,p.R48H|ENST00000272427,p.R48H	protein_coding, processed_transcript, nonsense_mediated_decay	uc010fep.3	nonsynonymous SNV	exon2	c.G143A	p.R48H	TLRSVYDGEEHGRFMEKLETRIRNH	TLRSVYDGEEHGHFMEKLETRIRNH	9.0	10.0	-	-	4278_2:72968569-72968569 C>T_TLRSVYDGEEHGHFMEKLETRIRNH	0.0
11:36596296-36596296 G>T	1.0	4287	COLORECTAL	-	-	-	-	RAG1	ENST00000534663,p.C481F|NM_000448,p.C481F|uc021qgb.1,p.C481F|ENST00000299440,p.C481F|uc001mwu.4,p.C481F	protein_coding, processed_transcript, nonsense_mediated_decay	uc021qgb.1	nonsynonymous SNV	exon1	c.G1442T	p.C481F	VCLAIRVNTFLSCSQYHKMYRTVKA	VCLAIRVNTFLSFSQYHKMYRTVKA	5.0	9.0	-	-	4287_11:36596296-36596296 G>T_VCLAIRVNTFLSFSQYHKMYRTVKA	0.0
12:49425353-49425353 G>A	1.0	3713	MELANOMA	-	-	-	1	KMT2D	uc001rta.4,p.P4379S|ENST00000301067,p.P4379S|NM_003482,p.P4379S	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon39	c.C13135T	p.P4379S	DTLFSKGLGPWDPPDNLAETQKPEQ	DTLFSKGLGPWDSPDNLAETQKPEQ	9.0	5.0	-	-	3713_12:49425353-49425353 G>A_DTLFSKGLGPWDSPDNLAETQKPEQ	0.0
2:228137792-228137792 C>T	0.0	4240	BREAST	0.0018	-	ID=COSM442421,COSM442420;OCCURENCE=1(breast)	-	COL4A3	uc002vom.2,p.T629M|ENST00000396578,p.T629M|NM_000091,p.T629M	retained_intron, protein_coding, processed_transcript	uc002vom.2	nonsynonymous SNV	exon26	c.C1886T	p.T629M	GYGPQGEPGLQGTQGVPGAPGPPGE	GYGPQGEPGLQGMQGVPGAPGPPGE	2.0	7.0	-	-	4240_2:228137792-228137792 C>T_GYGPQGEPGLQGMQGVPGAPGPPGE	0.0
11:64824895-64824895 A>G	0.0	4345	COLORECTAL	-	-	-	-	NAALADL1	ENST00000358658,p.L184P|ENST00000339885,p.L184P|NM_005468,p.L184P|ENST00000355369,p.L184P|ENST00000356632,p.L184P|uc001ocn.3,p.L184P|ENST00000340252,p.L184P	retained_intron, protein_coding, nonsense_mediated_decay	uc001ocn.3	nonsynonymous SNV	exon4	c.T551C	p.L184P	EDFKELQTQGIKLEGTIALTRYGGV	EDFKELQTQGIKPEGTIALTRYGGV	5.0	6.0	-	-	4345_11:64824895-64824895 A>G_EDFKELQTQGIKPEGTIALTRYGGV	0.0
3:122829849-122829849 C>A	1.0	3678	MELANOMA	-	-	-	-	PDIA5	uc003egc.2,p.P180H|NM_006810,p.P180H|ENST00000316218,p.P180H|ENST00000489923,p.P180H	protein_coding, processed_transcript, nonsense_mediated_decay	uc003egc.2	nonsynonymous SNV	exon7	c.C539A	p.P180H	KEEKPLLIMFYAPWCSMCKRMMPHF	KEEKPLLIMFYAHWCSMCKRMMPHF	8.0	1.0	-	-	3678_3:122829849-122829849 C>A_KEEKPLLIMFYAHWCSMCKRMMPHF	0.0
12:106633373-106633373 A>C	1.0	4037	NSCLC	-	-	-	-	CKAP4	uc001tlk.3,p.L413R|ENST00000378026,p.L413R|NM_006825,p.L413R	protein_coding, processed_transcript	uc001tlk.3	nonsynonymous SNV	exon2	c.T1238G	p.L413R	ALQQKSQGLDSRLQHVEDGVLSMQV	ALQQKSQGLDSRRQHVEDGVLSMQV	10.0	10.0	-	-	4037_12:106633373-106633373 A>C_ALQQKSQGLDSRRQHVEDGVLSMQV	0.0
1:76349465-76349465 A>C	0.0	4298	COLORECTAL	-	-	-	-	MSH4	uc001dhd.2,p.Y689S|NM_002440,p.Y689S|ENST00000263187,p.Y689S	protein_coding	uc001dhd.2	nonsynonymous SNV	exon15	c.A2066C	p.Y689S	IITGPNMSGKSTYLKQIALCQIMAQ	IITGPNMSGKSTSLKQIALCQIMAQ	2.0	7.0	-	-	4298_1:76349465-76349465 A>C_IITGPNMSGKSTSLKQIALCQIMAQ	0.0
15:32928613-32928613 G>A	1.0	3713	MELANOMA	-	-	-	-	ARHGAP11A	uc010ubx.1,p.E358K|ENST00000565905,p.E358K|NM_014783,p.E547K|uc010ubw.1,p.E358K|ENST00000543522,p.E358K|ENST00000361627,p.E547K|NM_001286480,p.E358K|NM_001286479,p.E358K|uc001zgy.1,p.E547K	retained_intron, protein_coding, processed_transcript	uc010ubx.1	nonsynonymous SNV	exon13	c.G1072A	p.E358K	NEASSMVENLEVENSLEPDIMVEKS	NEASSMVENLEVKNSLEPDIMVEKS	5.0	9.0	-	-	3713_15:32928613-32928613 G>A_NEASSMVENLEVKNSLEPDIMVEKS	0.0
5:465242-465242 C>T	1.0	4287	COLORECTAL	-	-	-	-	EXOC3	uc003jba.3,p.A598V|NM_007277,p.A598V|ENST00000315013,p.A598V|ENST00000512944,p.A598V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jba.3	nonsynonymous SNV	exon11	c.C1793T	p.A598V	IKKPYKKRMTAEAHRRVVVEYLRAV	IKKPYKKRMTAEVHRRVVVEYLRAV	7.0	10.0	-	-	4287_5:465242-465242 C>T_IKKPYKKRMTAEVHRRVVVEYLRAV	0.0
17:39925404-39925404 G>A	1.0	3713	MELANOMA	-	-	-	-	JUP	ENST00000393931,p.S175L|ENST00000420370,p.S175L|uc002hxr.2,p.S175L|uc002hxq.2,p.S175L|NM_002230,p.S175L|uc010wfs.2,p.S175L|ENST00000540235,p.S175L|ENST00000424457,p.S175L|uc002hxs.2,p.S175L|ENST00000437187,p.S175L|ENST00000393930,p.S175L|ENST00000310706,p.S175L|NM_021991,p.S175L|ENST00000449889,p.S175L	retained_intron, protein_coding	uc010wfs.2	nonsynonymous SNV	exon3	c.C524T	p.S175L	AMIVNQLSKKEASRRALMGSPQLVA	AMIVNQLSKKEALRRALMGSPQLVA	3.0	3.0	-	-	3713_17:39925404-39925404 G>A_AMIVNQLSKKEALRRALMGSPQLVA	0.0
12:57457893-57457893 A>C	0.0	4081	COLORECTAL	-	-	-	-	TMEM194A	ENST00000379391,p.L166V|NM_001130963,p.L239V|NM_015257,p.L166V|ENST00000300128,p.L239V|uc001smy.3,p.L239V|uc001smx.3,p.L166V	protein_coding, processed_transcript, nonsense_mediated_decay	uc001smy.3	nonsynonymous SNV	exon6	c.T715G	p.L239V	FSLYLIQLVFKNLQEIWRCYWQYLL	FSLYLIQLVFKNVQEIWRCYWQYLL	4.0	6.0	-	-	4081_12:57457893-57457893 A>C_FSLYLIQLVFKNVQEIWRCYWQYLL	0.0
8:73480273-73480273 T>G	0.0	4078	GASTRIC	-	-	-	-	KCNB2	ENST00000523207,p.F102V|uc003xzb.3,p.F102V|NM_004770,p.F102V	protein_coding	uc003xzb.3	nonsynonymous SNV	exon2	c.T304G	p.F102V	DRHPGAFTSILNFYRTGKLHMMEEM	DRHPGAFTSILNVYRTGKLHMMEEM	1.0	3.0	-	-	4078_8:73480273-73480273 T>G_DRHPGAFTSILNVYRTGKLHMMEEM	0.0
2:160706647-160706647 A>-	0.0	4345	COLORECTAL	-	-	-	-	LY75,LY75-CD302	ENST00000553424,p.F998fs|NM_002349,p.F998fs|ENST00000554112,p.F998fs|ENST00000504764,p.F998fs|NM_001198759,p.F998fs|uc010fos.3,p.F998fs|NM_001198760,p.F998fs|uc002ubc.4,p.F998fs|ENST00000263636,p.F998fs|ENST00000505052,p.F998fs|uc002ubb.4,p.F998fs	retained_intron, protein_coding, processed_transcript	uc010fos.3	frameshift deletion	exon23	c.2994delT	p.F998fs	TLPSVLSQIEQDFITSLLPDMEATLW	TLPSVLSQIEQDLLHPCFRIWKLLYGLVCAGLPMKR	7.0	6.0	-	-	4345_2:160706647-160706647 A>-_TLPSVLSQIEQDLLHPCFRIWKLLYGLVCAGLPMKR	0.0
2:138033596-138033596 G>T	0.0	4245	COLORECTAL	-	-	-	-	THSD7B	ENST00000272643,p.A834S|ENST00000409968,p.A834S|uc002tvb.3,p.A693S|uc002tva.1,p.A803S|ENST00000413152,p.A803S	retained_intron, protein_coding, processed_transcript	uc002tvb.3	nonsynonymous SNV	exon10	c.G2077T	p.A693S	SSEACGKGLQTRAVSCISDDNRSAE	SSEACGKGLQTRSVSCISDDNRSAE	3.0	9.0	-	-	4245_2:138033596-138033596 G>T_SSEACGKGLQTRSVSCISDDNRSAE	0.0
17:3651273-3651273 C>T	0.0	4259	COLORECTAL	-	-	ID=COSM2154321;OCCURENCE=2(central_nervous_system)	-	ITGAE	ENST00000263087,p.V700I|uc002fwo.4,p.V700I|NM_002208,p.V700I	retained_intron, protein_coding, processed_transcript	uc002fwo.4	nonsynonymous SNV	exon17	c.G2098A	p.V700I	FTPSALPIGFNGVVNVRLCFEISSV	FTPSALPIGFNGIVNVRLCFEISSV	9.0	5.0	-	-	4259_17:3651273-3651273 C>T_FTPSALPIGFNGIVNVRLCFEISSV	0.0
1:10725553-10725553 A>G	1.0	4037	NSCLC	-	-	-	-	CASZ1	ENST00000344008,p.L31P|uc001arp.2,p.L31P|uc001aro.4,p.L31P|ENST00000377022,p.L31P|NM_017766,p.L31P|NM_001079843,p.L31P|uc009vmx.2,p.L55P	retained_intron, protein_coding, processed_transcript	uc009vmx.2	nonsynonymous SNV	exon3	c.T164C	p.L55P	PAMAPKRKGGLKLNAICAKLSRQVV	PAMAPKRKGGLKPNAICAKLSRQVV	7.0	10.0	-	-	4037_1:10725553-10725553 A>G_PAMAPKRKGGLKPNAICAKLSRQVV	0.0
12:6701638-6701638 G>A	1.0	4266	COLORECTAL	-	-	ID=COSM942732;OCCURENCE=2(endometrium)	1	CHD4	uc001qpn.3,p.R950W|ENST00000544484,p.R954W|uc001qpp.3,p.R954W|NM_001273,p.R957W|NM_001297553,p.R950W|ENST00000544040,p.R950W|ENST00000309577,p.R957W|uc001qpo.3,p.R957W|ENST00000357008,p.R957W	retained_intron, protein_coding, processed_transcript	uc001qpp.3	nonsynonymous SNV	exon19	c.C2860T	p.R954W	KLHDMLGPHMLRRLKADVFKNMPSK	KLHDMLGPHMLRWLKADVFKNMPSK	10.0	10.0	-	-	4266_12:6701638-6701638 G>A_KLHDMLGPHMLRWLKADVFKNMPSK	0.0
X:55514129-55514129 A>C	1.0	4177	PANCREATIC	-	-	-	-	USP51	ENST00000500968,p.F415C|uc022bxu.1,p.F415C|NM_201286,p.F415C|uc004dun.2,p.F415C	protein_coding, processed_transcript	uc022bxu.1	nonsynonymous SNV	exon1	c.T1244G	p.F415C	PSLCLVCEMSSLFHAMYSGSRTPHI	PSLCLVCEMSSLCHAMYSGSRTPHI	5.0	10.0	-	-	4177_X:55514129-55514129 A>C_PSLCLVCEMSSLCHAMYSGSRTPHI	0.0
21:15558374-15558374 A>G	0.0	3795	MELANOMA	-	-	-	-	LIPI	uc021whh.1,p.L150P|uc002yjm.3,p.L171P|ENST00000536861,p.L150P|uc021whe.1,p.L150P|ENST00000344577,p.L171P|uc021whj.1,p.L150P|uc010gkw.2,p.L150P|uc021whf.1,p.L150P|NM_198996,p.L171P	protein_coding	uc021whj.1	nonsynonymous SNV	exon3	c.T449C	p.L150P	VHIKNLLKHGASLDNFHFIGVSLGA	VHIKNLLKHGASPDNFHFIGVSLGA	1.0	2.0	-	-	3795_21:15558374-15558374 A>G_VHIKNLLKHGASPDNFHFIGVSLGA	0.0
3:171944703-171944703 C>T	1.0	3713	MELANOMA	-	-	-	-	FNDC3B	ENST00000443501,p.P50L|uc003fhz.4,p.P77L|ENST00000416957,p.P77L|ENST00000336824,p.P77L|ENST00000415807,p.P77L|NM_001135095,p.P77L|NM_022763,p.P77L|uc003fhy.3,p.P77L	retained_intron, protein_coding, processed_transcript	uc003fhz.4	nonsynonymous SNV	exon4	c.C230T	p.P77L	AEVPMMSPNGSIPPIHVPPGYISQV	AEVPMMSPNGSILPIHVPPGYISQV	7.0	7.0	-	-	3713_3:171944703-171944703 C>T_AEVPMMSPNGSILPIHVPPGYISQV	0.0
20:51871408-51871408 G>A	0.0	3998	MELANOMA	-	-	-	-	TSHZ2	uc002xwo.3,p.E471K|ENST00000603338,p.E468K|NM_001193421,p.E468K|NM_173485,p.E471K|ENST00000329613,p.E468K|ENST00000371497,p.E471K|uc021wex.1,p.E468K	protein_coding, processed_transcript	uc021wex.1	nonsynonymous SNV	exon2	c.G1402A	p.E468K	ELKKESKKERPEETSKDEKVVKSED	ELKKESKKERPEKTSKDEKVVKSED	4.0	10.0	-	-	3998_20:51871408-51871408 G>A_ELKKESKKERPEKTSKDEKVVKSED	0.0
1:158590227-158590227 A>C	0.0	4213	COLORECTAL	-	-	-	-	SPTA1	uc001fst.1,p.H2050Q|ENST00000368148,p.H2050Q|NM_003126,p.H2050Q|ENST00000368147,p.H2047Q	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon44	c.T6150G	p.H2050Q	LQKAEDLFVEFAHKASALNNWCEKM	LQKAEDLFVEFAQKASALNNWCEKM	3.0	6.0	-	-	4213_1:158590227-158590227 A>C_LQKAEDLFVEFAQKASALNNWCEKM	0.0
1:248224587-248224587 A>G	0.0	4326	BREAST	-	-	-	-	OR2L3	ENST00000359959,p.T202A|uc001idx.1,p.T202A|NM_001004687,p.T202A	protein_coding	uc001idx.1	nonsynonymous SNV	exon1	c.A604G	p.T202A	DTWVYEGTVFLSTTIFLVFPFIAIS	DTWVYEGTVFLSATIFLVFPFIAIS	3.0	7.0	-	-	4326_1:248224587-248224587 A>G_DTWVYEGTVFLSATIFLVFPFIAIS	0.0
13:39265034-39265034 C>T	1.0	3903	MELANOMA	-	-	-	-	FREM2	NM_207361,p.P1185S|ENST00000280481,p.P1185S|uc001uwv.3,p.P1185S	protein_coding, processed_transcript	uc001uwv.3	nonsynonymous SNV	exon1	c.C3553T	p.P1185S	FSERQFFPIVIIPTNDEQPEMFMRE	FSERQFFPIVIISTNDEQPEMFMRE	5.0	7.0	-	-	3903_13:39265034-39265034 C>T_FSERQFFPIVIISTNDEQPEMFMRE	0.0
12:96350478-96350478 T>A	0.0	4160	COLORECTAL	-	-	-	-	AMDHD1	uc001tel.2,p.Y109N|NM_152435,p.Y109N|ENST00000266736,p.Y109N	retained_intron, protein_coding, nonsense_mediated_decay	uc001tel.2	nonsynonymous SNV	exon4	c.T325A	p.Y109N	VHEFAMKLAGATYMEIHQAGGGIHF	VHEFAMKLAGATNMEIHQAGGGIHF	2.0	5.0	-	-	4160_12:96350478-96350478 T>A_VHEFAMKLAGATNMEIHQAGGGIHF	0.0
13:39262582-39262600 GGGCTACTTGGTGAGCACC>-	0.0	4081	COLORECTAL	-	-	-	-	FREM2	NM_207361,p.Q367fs|ENST00000280481,p.Q367fs|uc001uwv.3,p.Q367fs	protein_coding, processed_transcript	uc001uwv.3	frameshift deletion	exon1	c.1101_1119del	p.Q367fs	LIFNLTSPFQPGQGYLVSTDDRSLP	LIFNLTSPFQPGQMIAACPFPPSLRGICGS	4.0	5.0	-	-	4081_13:39262582-39262600 GGGCTACTTGGTGAGCACC>-_LIFNLTSPFQPGQMIAACPFPPSLRGICGS	0.0
7:120610770-120610770 T>A	1.0	4078	GASTRIC	-	-	-	-	ING3	NM_019071,p.S313T|uc003vjp.3,p.S313T|uc011kns.2,p.S298T|ENST00000315870,p.S313T|uc003vjn.3,p.S313T|ENST00000431467,p.S298T|uc003vjo.3,p.S87T	retained_intron, protein_coding, nonsense_mediated_decay	uc011kns.2	nonsynonymous SNV	exon9	c.T892A	p.S298T	KSKNNNKSSSQQSSSSSSSSSLSSC	KSKNNNKSSSQQTSSSSSSSSLSSC	7.0	7.0	-	-	4078_7:120610770-120610770 T>A_KSKNNNKSSSQQTSSSSSSSSLSSC	0.0
3:111637937-111637937 G>A	1.0	3713	MELANOMA	-	-	-	-	PHLDB2	uc010hqa.3,p.E580K|uc003dyi.3,p.E166K|NM_145753,p.E580K|ENST00000412622,p.E580K|ENST00000393925,p.E580K|uc003dyh.3,p.E580K|NM_001134438,p.E580K|uc003dyg.3,p.E580K|NM_001134437,p.E607K|ENST00000495180,p.E166K|ENST00000481953,p.E580K|ENST00000431670,p.E580K|NM_001134439,p.E580K|ENST00000498699,p.E580K|uc003dyc.3,p.E607K|ENST00000393923,p.E607K|uc003dyd.3,p.E580K	retained_intron, protein_coding, processed_transcript	uc010hqa.3	nonsynonymous SNV	exon4	c.G1738A	p.E580K	LSILPKTPEGISEEQRSQELAAMEE	LSILPKTPEGISKEQRSQELAAMEE	2.0	10.0	-	-	3713_3:111637937-111637937 G>A_LSILPKTPEGISKEQRSQELAAMEE	0.0
12:116435017-116435017 C>T	1.0	4301	MELANOMA	-	-	-	-	MED13L	ENST00000281928,p.R863K|uc001tvw.3,p.R863K|NM_015335,p.R863K	retained_intron, protein_coding, processed_transcript	uc001tvw.3	nonsynonymous SNV	exon15	c.G2588A	p.R863K	AVPYPPTVADLQRMFPTPPSLEQHP	AVPYPPTVADLQKMFPTPPSLEQHP	8.0	1.0	-	-	4301_12:116435017-116435017 C>T_AVPYPPTVADLQKMFPTPPSLEQHP	0.0
1:179631299-179631299 G>A	0.0	4301	MELANOMA	-	-	-	-	TDRD5	ENST00000444136,p.D795N|NM_001199085,p.D795N|uc001gnf.2,p.D741N|NM_001199089,p.D795N|ENST00000417329,p.D251N|uc001gnh.2,p.D296N|uc010pnp.2,p.D795N|uc021pfn.1,p.D795N|NM_001199091,p.D741N|ENST00000294848,p.D741N|NM_173533,p.D741N|uc021pfm.1,p.D741N|NM_001199092,p.D296N|ENST00000367614,p.D741N	protein_coding	uc021pfn.1	nonsynonymous SNV	exon15	c.G2383A	p.D795N	CLESVTIGDDIWDENWLPLQAKMGK	CLESVTIGDDIWNENWLPLQAKMGK	2.0	9.0	-	-	4301_1:179631299-179631299 G>A_CLESVTIGDDIWNENWLPLQAKMGK	0.0
1:41474527-41474527 T>G	1.0	4180	BREAST	-	-	-	-	CTPS1	NM_001301237,p.V348G|NM_001905,p.V504G|uc010ojo.2,p.V273G|ENST00000372621,p.V504G|uc001cgl.4,p.V504G|ENST00000372616,p.V504G|uc010ojq.2,p.V348G|ENST00000541520,p.V273G|uc001cgk.4,p.V504G	protein_coding, processed_transcript	uc010ojq.2	nonsynonymous SNV	exon12	c.T1043G	p.V348G	LEEQGLKFVGQDVEGERMEIVELED	LEEQGLKFVGQDGEGERMEIVELED	9.0	6.0	-	-	4180_1:41474527-41474527 T>G_LEEQGLKFVGQDGEGERMEIVELED	0.0
X:20156734-20156734 C>T	1.0	4155	MELANOMA	-	-	-	2	EIF1AX	uc004czt.3,p.G8E|ENST00000379607,p.G8E|NM_001412,p.G8E	protein_coding	uc004czt.3	nonsynonymous SNV	exon2	c.G23A	p.G8E	MPKNKGKGGKNRRRGKNENE	MPKNKGKEGKNRRRGKNENE	8.0	10.0	-	-	4155_X:20156734-20156734 C>T_MPKNKGKEGKNRRRGKNENE	0.0
15:90611774-90611774 G>A	1.0	4177	PANCREATIC	-	-	-	-	ZNF710	uc002bov.2,p.G469S|ENST00000558883,p.G177S|NM_198526,p.G469S|ENST00000268154,p.G469S	protein_coding, processed_transcript	uc002bov.2	nonsynonymous SNV	exon2	c.G1405A	p.G469S	HQNVRPFVCTECGMEFSQIHHLKQH	HQNVRPFVCTECSMEFSQIHHLKQH	8.0	8.0	-	-	4177_15:90611774-90611774 G>A_HQNVRPFVCTECSMEFSQIHHLKQH	0.0
3:169569563-169569563 G>A	0.0	4235	COLORECTAL	-	-	-	-	LRRC31	ENST00000264676,p.P279S|uc010hwp.2,p.P279S|NM_001277127,p.P335S|uc031scf.1,p.P335S|NM_001277128,p.P279S|uc003fgc.2,p.P335S|ENST00000316428,p.P335S|ENST00000523069,p.P335S|NM_024727,p.P335S	protein_coding, processed_transcript	uc031scf.1	nonsynonymous SNV	exon7	c.C1003T	p.P335S	TADDVMSLTQVIPLLSNLQELDLSA	TADDVMSLTQVISLLSNLQELDLSA	5.0	2.0	-	-	4235_3:169569563-169569563 G>A_TADDVMSLTQVISLLSNLQELDLSA	0.0
9:95768392-95768392 G>A	1.0	3903	MELANOMA	-	-	-	-	FGD3	NM_033086,p.R256Q|ENST00000416701,p.R256Q|NM_001083536,p.R256Q|uc004asz.2,p.R256Q|ENST00000467786,p.R256Q|ENST00000337352,p.R256Q|uc004asw.2,p.R256Q|uc004asx.2,p.R256Q|ENST00000375482,p.R256Q|NM_001286993,p.R256Q|uc004ata.3,p.R59Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc004ata.3	nonsynonymous SNV	exon3	c.G176A	p.R59Q	LKMYGEYVKNFDRAVGLVSTWTQRS	LKMYGEYVKNFDQAVGLVSTWTQRS	6.0	10.0	-	-	3903_9:95768392-95768392 G>A_LKMYGEYVKNFDQAVGLVSTWTQRS	0.0
12:46756405-46756405 G>C	0.0	4335	COLORECTAL	-	-	-	-	SLC38A2	uc001rpg.3,p.T399S|uc010sli.2,p.T237S|uc001rph.3,p.T299S|ENST00000256689,p.T399S|NM_018976,p.T399S|ENST00000551374,p.T237S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sli.2	nonsynonymous SNV	exon7	c.C710G	p.T237S	VPVVIFPIRSSVTHLLCASKDFSWW	VPVVIFPIRSSVSHLLCASKDFSWW	9.0	2.0	-	-	4335_12:46756405-46756405 G>C_VPVVIFPIRSSVSHLLCASKDFSWW	0.0
5:41929840-41929840 C>T	1.0	3713	MELANOMA	-	-	ID=COSM4141824,COSM4141823;OCCURENCE=1(ovary)	-	FBXO4	NM_001297437,p.S156F|ENST00000296812,p.S156F|ENST00000509134,p.S156F|NM_033484,p.S156F|ENST00000281623,p.S156F|NM_012176,p.S156F|uc003jmp.3,p.S156F|uc003jmq.3,p.S156F	retained_intron, protein_coding, nonsense_mediated_decay	uc003jmq.3	nonsynonymous SNV	exon3	c.C467T	p.S156F	RMCCPYTRRASKSSRPMYGAVTSFL	RMCCPYTRRASKFSRPMYGAVTSFL	3.0	6.0	-	-	3713_5:41929840-41929840 C>T_RMCCPYTRRASKFSRPMYGAVTSFL	0.0
17:8243591-8243591 C>G	0.0	4110	BILE DUCT	-	-	-	-	ODF4	ENST00000328248,p.H74Q|uc002gle.1,p.H74Q|NM_153007,p.H74Q	protein_coding	uc002gle.1	nonsynonymous SNV	exon1	c.C222G	p.H74Q	QNSPLPFQWRITHSFRWMAQVLASE	QNSPLPFQWRITQSFRWMAQVLASE	1.0	9.0	-	-	4110_17:8243591-8243591 C>G_QNSPLPFQWRITQSFRWMAQVLASE	0.0
7:65554102-65554102 G>C	1.0	4335	COLORECTAL	-	-	-	-	ASL	ENST00000395332,p.Q286H|uc003tur.3,p.Q260H|ENST00000380839,p.Q260H|uc003tuq.3,p.Q286H|ENST00000395331,p.Q286H|ENST00000362000,p.Q221H|ENST00000304874,p.Q286H|uc003tuo.3,p.Q286H|NM_001024943,p.Q286H|NM_001024946,p.Q260H|NM_000048,p.Q286H|uc003tup.3,p.Q286H|NM_001024944,p.Q286H	retained_intron, processed_transcript, protein_coding	uc003tur.3	nonsynonymous SNV	exon10	c.G780C	p.Q260H	SDAYSTGSSLMPQKKNPDSLELIRS	SDAYSTGSSLMPHKKNPDSLELIRS	10.0	7.0	-	-	4335_7:65554102-65554102 G>C_SDAYSTGSSLMPHKKNPDSLELIRS	0.0
3:146179626-146179626 G>A	0.0	4301	MELANOMA	-	-	-	-	PLSCR2	NM_001199978,p.S12F|ENST00000497985,p.S12F|uc021xfa.1,p.S12F	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xfa.1	nonsynonymous SNV	exon3	c.C35T	p.S12F	MRSWNSLFCLNSSRPPGHIVYPKH	MRSWNSLFCLNFSRPPGHIVYPKH	3.0	6.0	-	-	4301_3:146179626-146179626 G>A_MRSWNSLFCLNFSRPPGHIVYPKH	0.0
17:43311031-43311031 C>T	1.0	3466	MELANOMA	-	-	-	-	FMNL1	ENST00000331495,p.L140F|ENST00000328118,p.L140F|uc002iin.3,p.L140F|uc002iip.1,p.L134F|NM_005892,p.L140F|uc002iio.3,p.L85F	retained_intron, protein_coding, processed_transcript	uc002iip.1	nonsynonymous SNV	exon2	c.C400T	p.L134F	LRTNHIGWVQEFLNEENRGLDVLLE	LRTNHIGWVQEFFNEENRGLDVLLE	8.0	9.0	-	-	3466_17:43311031-43311031 C>T_LRTNHIGWVQEFFNEENRGLDVLLE	0.0
17:10363406-10363406 C>T	0.0	4196	COLORECTAL	-	-	-	-	MYH4	uc002gmn.3,p.V427M|ENST00000255381,p.V427M|NM_017533,p.V427M	protein_coding	uc002gmn.3	nonsynonymous SNV	exon14	c.G1279A	p.V427M	TKGQTVQQVYNAVGALAKAIYEKMF	TKGQTVQQVYNAMGALAKAIYEKMF	5.0	9.0	-	-	4196_17:10363406-10363406 C>T_TKGQTVQQVYNAMGALAKAIYEKMF	0.0
5:79355696-79355696 G>A	0.0	2359	MELANOMA	-	-	-	-	THBS4	NM_003248,p.G319R|uc021yaw.1,p.G319R|ENST00000511733,p.G228R|ENST00000350881,p.G319R	protein_coding, processed_transcript	uc021yaw.1	nonsynonymous SNV	exon7	c.G955A	p.G319R	GFQCGPCPEGYTGNGITCIDVDECK	GFQCGPCPEGYTRNGITCIDVDECK	4.0	9.0	-	-	2359_5:79355696-79355696 G>A_GFQCGPCPEGYTRNGITCIDVDECK	0.0
20:3102383-3102383 C>T	1.0	4240	BREAST	-	-	ID=COSM1240598;OCCURENCE=1(oesophagus)	-	UBOX5	NM_014948,p.R301Q|uc002why.2,p.R301Q|uc002whx.4,p.R301Q|uc002whw.4,p.R301Q|NM_199415,p.R301Q|ENST00000348031,p.R301Q|NM_001267584,p.R301Q|ENST00000217173,p.R301Q	protein_coding	uc002why.2	nonsynonymous SNV	exon3	c.G902A	p.R301Q	LEKCNRSEATWGRVPSDPFTGVAFT	LEKCNRSEATWGQVPSDPFTGVAFT	7.0	7.0	-	-	4240_20:3102383-3102383 C>T_LEKCNRSEATWGQVPSDPFTGVAFT	0.0
1:17735596-17735596 C>T	1.0	4246	COLORECTAL	-	-	-	-	RCC2	ENST00000375433,p.R520Q|ENST00000375436,p.R520Q|uc001bam.3,p.R520Q|uc001bal.3,p.R520Q|NM_001136204,p.R520Q|NM_018715,p.R520Q	protein_coding, processed_transcript	uc001bam.3	nonsynonymous SNV	exon13	c.G1559A	p.R520Q	KEKIKKLPEYNPRTL	KEKIKKLPEYNPQTL	9.0	7.0	-	-	4246_1:17735596-17735596 C>T_KEKIKKLPEYNPQTL	0.0
8:54896990-54896990 G>-	0.0	4258	ENDOMETRIAL	-	-	-	1	TCEA1	uc003xru.3,p.P204fs|NM_201437,p.P183fs|ENST00000396401,p.P183fs|ENST00000521604,p.P204fs|NM_006756,p.P204fs|uc003xrv.3,p.P183fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc003xrv.3	frameshift deletion	exon6	c.548delC	p.P183fs	RSRISNLKDAKNPNLRKNVLCGNIP	RSRISNLKDAKNQI	8.0	7.0	-	-	4258_8:54896990-54896990 G>-_RSRISNLKDAKNQI	0.0
3:182933812-182933812 T>A	0.0	4298	COLORECTAL	-	-	-	-	MCF2L2	NM_015078,p.D814V|ENST00000473233,p.D814V|uc003fli.1,p.D814V|ENST00000328913,p.D814V	retained_intron, protein_coding, processed_transcript	uc003fli.1	nonsynonymous SNV	exon22	c.A2441T	p.D814V	STELQQALAVIEDLIKSCELAVDLA	STELQQALAVIEVLIKSCELAVDLA	5.0	2.0	-	-	4298_3:182933812-182933812 T>A_STELQQALAVIEVLIKSCELAVDLA	0.0
11:67810301-67810301 G>A	1.0	4284	COLORECTAL	-	-	-	-	TCIRG1	ENST00000265686,p.A130T|uc001onf.1,p.A130T|ENST00000524598,p.A116T|uc001one.3,p.A130T|ENST00000534673,p.A130T|NM_006019,p.A130T|ENST00000529657,p.A130T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001onf.1	nonsynonymous SNV	exon4	c.G388A	p.A130T	LRAQLHQLQLHAAVLRQGHEPQLAA	LRAQLHQLQLHATVLRQGHEPQLAA	9.0	5.0	-	-	4284_11:67810301-67810301 G>A_LRAQLHQLQLHATVLRQGHEPQLAA	0.0
3:100617690-100617690 G>A	1.0	2556	MELANOMA	-	-	-	-	ABI3BP	ENST00000530539,p.T73I|uc003dup.4,p.T126I|ENST00000284322,p.T133I|NM_015429,p.T133I|uc003dun.3,p.T133I|uc003duo.2,p.T126I|ENST00000495063,p.T133I|ENST00000527258,p.T52I|ENST00000471714,p.T133I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003dup.4	nonsynonymous SNV	exon4	c.C377T	p.T126I	SRKPLQLVVGTLTPSSVFLSWGFLI	SRKPLQLVVGTLIPSSVFLSWGFLI	5.0	6.0	-	-	2556_3:100617690-100617690 G>A_SRKPLQLVVGTLIPSSVFLSWGFLI	0.0
4:20598173-20598173 G>T	0.0	4129	NSCLC	-	-	-	-	SLIT2	ENST00000504154,p.Q1152H|uc003gpr.1,p.Q1152H|ENST00000503823,p.Q1144H|NM_001289135,p.Q1148H|NM_004787,p.Q1152H|uc003gps.1,p.Q1144H|ENST00000273739,p.Q1165H|ENST00000503837,p.Q1148H|NM_001289136,p.Q1144H	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon31	c.G3432T	p.Q1144H	INEPICQCLPGYQGEKCEKLVSVNF	INEPICQCLPGYHGEKCEKLVSVNF	4.0	9.0	-	-	4129_4:20598173-20598173 G>T_INEPICQCLPGYHGEKCEKLVSVNF	0.0
4:8233804-8233804 T>C	0.0	3775	CERVICAL	-	-	-	-	SH3TC1	ENST00000539824,p.C942R|uc003gkw.4,p.C942R|uc003gkv.4,p.C1018R|ENST00000245105,p.C1018R|NM_018986,p.C1018R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gkw.4	nonsynonymous SNV	exon13	c.T2824C	p.C942R	CVIYHELQLSLACKVADKVLEGQLL	CVIYHELQLSLARKVADKVLEGQLL	7.0	5.0	-	-	3775_4:8233804-8233804 T>C_CVIYHELQLSLARKVADKVLEGQLL	0.0
9:77377070-77377070 G>A	0.0	3795	MELANOMA	-	-	-	-	TRPM6	ENST00000449912,p.S1501L|ENST00000376864,p.S1506L|NM_017662,p.S1506L|ENST00000360774,p.S1506L|uc022bib.1,p.S1501L|uc004ajl.1,p.S1506L|ENST00000451710,p.S1506L|uc004ajk.1,p.S1501L|NM_001177311,p.S1501L|NM_001177310,p.S1501L|uc004ajj.1,p.S462L|ENST00000361255,p.S1501L	protein_coding, processed_transcript	uc022bib.1	nonsynonymous SNV	exon26	c.C4502T	p.S1501L	AQDSSLSDNSTRSAQSSECSEVGPW	AQDSSLSDNSTRLAQSSECSEVGPW	2.0	10.0	-	-	3795_9:77377070-77377070 G>A_AQDSSLSDNSTRLAQSSECSEVGPW	0.0
12:56998406-56998406 G>A	1.0	3713	MELANOMA	-	-	-	-	BAZ2A	NM_013449,p.L978F|ENST00000379441,p.L948F|uc001slp.1,p.L976F|NM_001300905,p.L976F|uc001slq.1,p.L978F|uc009zow.1,p.L946F|ENST00000549884,p.L976F|ENST00000179765,p.L946F|ENST00000551812,p.L978F	retained_intron, protein_coding, processed_transcript	uc009zow.1	nonsynonymous SNV	exon15	c.C2836T	p.L946F	QPPQQKAAVLAFLVHELNGSTLIIN	QPPQQKAAVLAFFVHELNGSTLIIN	9.0	5.0	-	-	3713_12:56998406-56998406 G>A_QPPQQKAAVLAFFVHELNGSTLIIN	0.0
14:76905784-76905784 C>T	0.0	4301	MELANOMA	-	-	-	-	ESRRB	ENST00000505752,p.L30F|uc001xsr.3,p.L30F|ENST00000509242,p.L30F|ENST00000380887,p.L30F|ENST00000512784,p.L35F|uc001xsq.1,p.L30F|NM_004452,p.L30F|ENST00000261532,p.L30F|ENST00000556177,p.L30F	protein_coding, processed_transcript, nonsense_mediated_decay	uc001xsr.3	nonsynonymous SNV	exon4	c.C88T	p.L30F	TEPSSPSSGIDALSHHSPSGSSDAS	TEPSSPSSGIDAFSHHSPSGSSDAS	2.0	7.0	-	-	4301_14:76905784-76905784 C>T_TEPSSPSSGIDAFSHHSPSGSSDAS	0.0
5:178506626-178506626 C>T	0.0	2359	MELANOMA	-	-	-	-	ZNF354C	NM_014594,p.T398I|uc003mju.3,p.T398I|ENST00000315475,p.T398I	protein_coding	uc003mju.3	nonsynonymous SNV	exon5	c.C1193T	p.T398I	CLECGRTFTRIVTLIEHQRIHTGQK	CLECGRTFTRIVILIEHQRIHTGQK	4.0	9.0	-	-	2359_5:178506626-178506626 C>T_CLECGRTFTRIVILIEHQRIHTGQK	0.0
1:248224768-248224768 G>T	0.0	4259	COLORECTAL	-	-	-	-	OR2L3	NM_001004687,p.R262I|ENST00000359959,p.R262I|uc001idx.1,p.R262I	protein_coding	uc001idx.1	nonsynonymous SNV	exon1	c.G785T	p.R262I	YYAPFVYTYLRPRSLRSPTEDKVLA	YYAPFVYTYLRPISLRSPTEDKVLA	1.0	8.0	-	-	4259_1:248224768-248224768 G>T_YYAPFVYTYLRPISLRSPTEDKVLA	0.0
2:118582657-118582657 T>A	1.0	4234	NSCLC	-	-	-	-	DDX18	ENST00000415038,p.L114M|ENST00000263239,p.L450M|NM_006773,p.L450M|uc002tlh.1,p.L450M	retained_intron, protein_coding, processed_transcript	uc002tlh.1	nonsynonymous SNV	exon9	c.T1348A	p.L450M	VKYHYELLNYIDLPVLAIHGKQKQN	VKYHYELLNYIDMPVLAIHGKQKQN	9.0	5.0	-	-	4234_2:118582657-118582657 T>A_VKYHYELLNYIDMPVLAIHGKQKQN	0.0
19:32083709-32083709 G>A	0.0	4301	MELANOMA	-	-	-	-	THEG5	ENST00000607852,p.G71R|NM_001278575,p.G63R|NM_001278577,p.G63R|NM_001278576,p.G63R|NM_001278578,p.G63R|uc021urz.1,p.G71R|NM_001205273,p.G71R	-	uc021urz.1	nonsynonymous SNV	exon2	c.G211A	p.G71R	GCGSDGSTAVHPGGWTCVPGYQSLR	GCGSDGSTAVHPRGWTCVPGYQSLR	1.0	4.0	-	-	4301_19:32083709-32083709 G>A_GCGSDGSTAVHPRGWTCVPGYQSLR	0.0
5:140502130-140502130 C>T	1.0	2556	MELANOMA	-	-	-	-	PCDHB4	uc003lip.1,p.H184Y|ENST00000194152,p.H184Y|NM_018938,p.H184Y	protein_coding	uc003lip.1	nonsynonymous SNV	exon1	c.C550T	p.H184Y	SPNSHFHILTRNHSEGKKYPDLVQD	SPNSHFHILTRNYSEGKKYPDLVQD	4.0	8.0	-	-	2556_5:140502130-140502130 C>T_SPNSHFHILTRNYSEGKKYPDLVQD	0.0
X:78618468-78618468 G>A	0.0	2556	MELANOMA	-	-	-	-	ITM2A	uc011mqr.2,p.P94S|NM_004867,p.P138S|ENST00000373298,p.P138S|ENST00000434584,p.P94S|uc004edh.3,p.P138S|NM_001171581,p.P94S	protein_coding, processed_transcript	uc011mqr.2	nonsynonymous SNV	exon2	c.C280T	p.P94S	IDVPVPSFSDSDPAAIIHDFEKGMT	IDVPVPSFSDSDSAAIIHDFEKGMT	4.0	3.0	-	-	2556_X:78618468-78618468 G>A_IDVPVPSFSDSDSAAIIHDFEKGMT	0.0
5:158601106-158601106 G>A	1.0	3784	MELANOMA	-	-	-	-	RNF145	NM_144726,p.P256S|uc003lxp.3,p.P228S|uc010jiq.2,p.P258S|ENST00000519865,p.P228S|ENST00000424310,p.P228S|uc011dea.2,p.P244S|ENST00000518802,p.P258S|ENST00000520638,p.P242S|NM_001199381,p.P245S|NM_001199383,p.P228S|ENST00000521606,p.P245S|NM_001199380,p.P258S|uc003lxo.2,p.P256S|ENST00000274542,p.P256S|NM_001199382,p.P242S|uc011ddz.2,p.P245S|uc011ddy.2,p.P242S	retained_intron, protein_coding, processed_transcript	uc011dea.2	nonsynonymous SNV	exon6	c.C730T	p.P244S	ALGMSLWNQLVVPVLFMVFWLVLFA	ALGMSLWNQLVVSVLFMVFWLVLFA	9.0	5.0	-	-	3784_5:158601106-158601106 G>A_ALGMSLWNQLVVSVLFMVFWLVLFA	0.0
3:17053148-17053148 A>T	0.0	4259	COLORECTAL	-	-	-	-	PLCL2	ENST00000418129,p.K644N|uc011awd.2,p.K644N|NM_015184,p.K644N|ENST00000396755,p.K644N|ENST00000432376,p.K644N	protein_coding, processed_transcript	uc011awd.2	nonsynonymous SNV	exon2	c.A1932T	p.K644N	IKIISGQNFPKPKGSGAKGDVVDPY	IKIISGQNFPKPNGSGAKGDVVDPY	6.0	8.0	-	-	4259_3:17053148-17053148 A>T_IKIISGQNFPKPNGSGAKGDVVDPY	0.0
7:128498064-128498064 C>T	1.0	3784	MELANOMA	-	-	-	-	FLNC	uc003voa.4,p.P2562S|uc003vnz.4,p.P2595S|NM_001127487,p.P2562S|ENST00000346177,p.P2562S|NM_001458,p.P2595S|ENST00000325888,p.P2595S	retained_intron, protein_coding	uc003voa.4	nonsynonymous SNV	exon46	c.C7684T	p.P2562S	IVGSPFKAKVTGPRLSGGHSLHETS	IVGSPFKAKVTGSRLSGGHSLHETS	5.0	9.0	-	-	3784_7:128498064-128498064 C>T_IVGSPFKAKVTGSRLSGGHSLHETS	0.0
11:120984328-120984328 G>A	0.0	4081	COLORECTAL	-	-	-	-	TECTA	uc010rzo.2,p.V231M|ENST00000392793,p.V231M|ENST00000264037,p.V231M|NM_005422,p.V231M	protein_coding, processed_transcript	uc010rzo.2	nonsynonymous SNV	exon5	c.G691A	p.V231M	FFSLPGSRTPEIVNIQETTNVNVPG	FFSLPGSRTPEIMNIQETTNVNVPG	2.0	4.0	-	-	4081_11:120984328-120984328 G>A_FFSLPGSRTPEIMNIQETTNVNVPG	0.0
11:119050543-119050543 G>A	0.0	4240	BREAST	-	-	-	-	NLRX1	NM_001282143,p.E605K|uc001pvu.3,p.E605K|uc001pvx.3,p.E605K|NM_001282144,p.E605K|ENST00000525863,p.E605K|NM_024618,p.E605K|ENST00000409265,p.E605K|ENST00000292199,p.E605K|uc001pvv.3,p.E605K|uc001pvw.3,p.E605K|ENST00000409109,p.E605K|ENST00000409991,p.E605K|NM_001282358,p.E605K|uc010rzc.1,p.E427K	retained_intron, protein_coding, processed_transcript	uc010rzc.1	nonsynonymous SNV	exon6	c.G1279A	p.E427K	VLDQMGASILGVEGPRRHPDEPPED	VLDQMGASILGVKGPRRHPDEPPED	5.0	10.0	-	-	4240_11:119050543-119050543 G>A_VLDQMGASILGVKGPRRHPDEPPED	0.0
3:105268974-105268974 G>A	0.0	2369	MELANOMA	-	-	-	-	ALCAM	uc010hpp.3,p.E182K|ENST00000389927,p.E182K|ENST00000472644,p.E460K|NM_001243280,p.E460K|uc003dvz.3,p.E94K|uc003dvw.2,p.E460K|NM_001243281,p.E460K|ENST00000486979,p.E409K|ENST00000306107,p.E460K|uc003dvx.3,p.E460K|uc003dvy.3,p.E460K|NM_001627,p.E460K	retained_intron, protein_coding, processed_transcript	uc010hpp.3	nonsynonymous SNV	exon6	c.G544A	p.E182K	TITGSGSVINQTEESPYINGRYYSK	TITGSGSVINQTKESPYINGRYYSK	8.0	7.0	-	-	2369_3:105268974-105268974 G>A_TITGSGSVINQTKESPYINGRYYSK	0.0
2:61528289-61528289 A>C	1.0	4213	COLORECTAL	-	-	-	-	USP34	ENST00000398571,p.F1309V|uc002sbe.3,p.F1309V|NM_014709,p.F1309V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002sbe.3	nonsynonymous SNV	exon29	c.T3925G	p.F1309V	LHELGFKDMQMVFVSLGAPRRERKG	LHELGFKDMQMVVVSLGAPRRERKG	9.0	6.0	-	-	4213_2:61528289-61528289 A>C_LHELGFKDMQMVVVSLGAPRRERKG	0.0
8:65493597-65493597 G>T	0.0	4149	OVARIAN	-	-	-	-	BHLHE22	NM_152414,p.G84C|uc003xvi.3,p.G84C|ENST00000321870,p.G84C	protein_coding	uc003xvi.3	nonsynonymous SNV	exon1	c.G250T	p.G84C	GAGLLLPPPGGGGGGSAGSGGGGGG	GAGLLLPPPGGGCGGSAGSGGGGGG	3.0	6.0	-	-	4149_8:65493597-65493597 G>T_GAGLLLPPPGGGCGGSAGSGGGGGG	0.0
14:23856803-23856803 C>T	0.0	3903	MELANOMA	-	-	-	-	MYH6	uc001wjv.3,p.E1529K|NM_002471,p.E1529K|ENST00000405093,p.E1529K|ENST00000356287,p.E1529K	retained_intron, protein_coding	uc001wjv.3	nonsynonymous SNV	exon32	c.G4585A	p.E1529K	QLGEGGKNVHELEKVRKQLEVEKLE	QLGEGGKNVHELKKVRKQLEVEKLE	1.0	8.0	-	-	3903_14:23856803-23856803 C>T_QLGEGGKNVHELKKVRKQLEVEKLE	0.0
19:55699534-55699534 G>A	0.0	4155	MELANOMA	-	-	-	-	PTPRH	uc002qjq.3,p.S796F|NM_002842,p.S796F|ENST00000263434,p.S618F|NM_001161440,p.S618F|ENST00000376350,p.S796F|uc010esv.3,p.S618F	protein_coding, processed_transcript	uc010esv.3	nonsynonymous SNV	exon11	c.C1853T	p.S618F	QQKPELRDLVFSSPGDIPAEDFADH	QQKPELRDLVFSFPGDIPAEDFADH	5.0	3.0	-	-	4155_19:55699534-55699534 G>A_QQKPELRDLVFSFPGDIPAEDFADH	0.0
9:116956726-116956726 G>A	1.0	3713	MELANOMA	-	-	ID=COSM170416;OCCURENCE=1(large_intestine)	-	COL27A1	uc011lxl.2,p.D687N|NM_032888,p.D687N|ENST00000356083,p.D687N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lxl.2	nonsynonymous SNV	exon6	c.G2059A	p.D687N	KGDPGLSPGKAHDGAKGDMGLPGLS	KGDPGLSPGKAHNGAKGDMGLPGLS	3.0	8.0	-	-	3713_9:116956726-116956726 G>A_KGDPGLSPGKAHNGAKGDMGLPGLS	0.0
2:202134247-202134247 G>A	1.0	4346	COLORECTAL	-	-	-	1	CASP8	ENST00000264275,p.R107H|uc002uxp.1,p.R107H|NM_001228,p.R107H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uxp.1	nonsynonymous SNV	exon4	c.G320A	p.R107H	RAQISAYRFHFCRMSWAEANSQCQT	RAQISAYRFHFCHMSWAEANSQCQT	10.0	7.0	-	-	4346_2:202134247-202134247 G>A_RAQISAYRFHFCHMSWAEANSQCQT	0.0
17:4863405-4863405 T>A	1.0	4037	NSCLC	-	-	-	-	SPAG7	ENST00000573366,p.E59V|uc002gaf.3,p.E110V|ENST00000575142,p.E99V|ENST00000206020,p.E110V|uc002gae.3,p.E110V|NM_004890,p.E110V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002gaf.3	nonsynonymous SNV	exon5	c.A329T	p.E110V	DDDCRYVMIFKKEFAPSDEELDSYR	DDDCRYVMIFKKVFAPSDEELDSYR	7.0	7.0	-	-	4037_17:4863405-4863405 T>A_DDDCRYVMIFKKVFAPSDEELDSYR	0.0
2:96993335-96993335 C>A	0.0	4126	NSCLC	-	-	-	-	ITPRIPL1	uc010yul.2,p.F314L|uc002svy.3,p.F330L|ENST00000361124,p.F330L|NM_001008949,p.F322L|ENST00000536814,p.F314L|NM_178495,p.F330L|NM_001163523,p.F314L|ENST00000439118,p.F322L|NM_001163524,p.F314L|ENST00000542887,p.F314L|uc010yuk.2,p.F314L|uc002svx.3,p.F322L	protein_coding	uc010yul.2	nonsynonymous SNV	exon2	c.C942A	p.F314L	GFHLDVCKTVQWFRNMMGNAWALVA	GFHLDVCKTVQWLRNMMGNAWALVA	3.0	6.0	-	-	4126_2:96993335-96993335 C>A_GFHLDVCKTVQWLRNMMGNAWALVA	0.0
15:90764695-90764695 C>T	1.0	4000	MELANOMA	-	-	-	-	SEMA4B	uc002bpa.3,p.S69F|uc010uqd.2,p.S69F|NM_020210,p.S231F|ENST00000411539,p.S231F|NM_198925,p.S231F|ENST00000379122,p.S226F|uc002boz.3,p.S231F|uc002boy.3,p.S231F|ENST00000332496,p.S231F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uqd.2	nonsynonymous SNV	exon7	c.C206T	p.S69F	RSQSLRPTKTESSLNWLQDPAFVAS	RSQSLRPTKTESFLNWLQDPAFVAS	8.0	9.0	-	-	4000_15:90764695-90764695 C>T_RSQSLRPTKTESFLNWLQDPAFVAS	0.0
20:50701700-50701700 T>C	1.0	4252	COLORECTAL	-	-	-	-	ZFP64	NM_199427,p.E445G|uc002xwj.3,p.E226G|ENST00000361387,p.E445G|uc002xwk.3,p.E445G|ENST00000371523,p.E226G	protein_coding, processed_transcript	uc002xwk.3	nonsynonymous SNV	exon9	c.A1334G	p.E445G	MIVHSGEKPFKCEFCDVRCTMKANL	MIVHSGEKPFKCGFCDVRCTMKANL	8.0	1.0	-	-	4252_20:50701700-50701700 T>C_MIVHSGEKPFKCGFCDVRCTMKANL	0.0
12:549784-549784 C>T	0.0	4189	MELANOMA	-	-	-	-	CCDC77	uc010sdp.2,p.S316F|ENST00000422000,p.S316F|uc001qig.3,p.S348F|uc009zdk.3,p.S316F|uc010sdq.2,p.S316F|NM_001130147,p.S316F|ENST00000412006,p.S316F|ENST00000239830,p.S348F|ENST00000543504,p.S316F|NM_032358,p.S348F|NM_001130146,p.S316F|NM_001130148,p.S316F|ENST00000540180,p.S316F	retained_intron, protein_coding, processed_transcript	uc010sdq.2	nonsynonymous SNV	exon10	c.C947T	p.S316F	HESHHAQSEYIKSLKDKLVQEKKLS	HESHHAQSEYIKFLKDKLVQEKKLS	7.0	1.0	-	-	4189_12:549784-549784 C>T_HESHHAQSEYIKFLKDKLVQEKKLS	0.0
7:134632356-134632357 GG>-	1.0	4234	NSCLC	-	-	-	-	CALD1	uc003vry.3,p.G289fs|ENST00000422748,p.G315fs|uc003vrz.3,p.G544fs|NM_033138,p.G544fs|uc003vsc.3,p.G309fs|ENST00000436461,p.G289fs|uc003vsd.3,p.G283fs|NM_033140,p.G283fs|ENST00000424922,p.G283fs|uc010lmm.3,p.G315fs|ENST00000443197,p.G283fs|NM_033157,p.G315fs|ENST00000393118,p.G309fs|ENST00000361675,p.G544fs|ENST00000361388,p.G315fs|uc003vsb.3,p.G289fs|ENST00000495522,p.G309fs|NM_033139,p.G309fs|ENST00000543443,p.G294fs|uc011kpv.2,p.G153fs|uc003vse.3,p.G408fs|ENST00000361901,p.G289fs|uc011kpt.2,p.G63fs|ENST00000417172,p.G289fs|NM_004342,p.G289fs|uc011kpu.2,p.G294fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kpv.2	frameshift deletion	exon4	c.457_458del	p.G153fs	AGKRLEELRRRRGETESEEFEKLKQK	AGKRLEELRRRRGDRERRVREAQTEAAGGGFGAGGTQEKEGGEKEGPGGGRAEEEAGGSRSKTQRGGREEEAKGRD	9.0	5.0	-	-	4234_7:134632356-134632357 GG>-_AGKRLEELRRRRGDRERRVREAQTEAAGGGFGAGGTQEKEGGEKEGPGGGRAEEEAGGSRSKTQRGGREEEAKGRD	0.0
4:94145872-94145872 A>T	0.0	4301	MELANOMA	-	-	-	-	GRID2	uc011cdu.2,p.R262S|NM_001510,p.R357S|ENST00000282020,p.R357S|uc010ikz.1,p.R38S|uc011cdt.2,p.R357S|ENST00000512631,p.R38S|ENST00000510992,p.R262S|NM_001286838,p.R262S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011cdu.2	nonsynonymous SNV	exon6	c.A786T	p.R262S	RKWHSMASLSCIRKNSKPWQGGRSM	RKWHSMASLSCISKNSKPWQGGRSM	2.0	3.0	-	-	4301_4:94145872-94145872 A>T_RKWHSMASLSCISKNSKPWQGGRSM	0.0
4:160268138-160268138 C>T	1.0	4000	MELANOMA	-	-	-	-	RAPGEF2	uc003iqg.4,p.L1073F|NM_014247,p.L1073F|ENST00000264431,p.L1073F	retained_intron, protein_coding, processed_transcript	uc003iqg.4	nonsynonymous SNV	exon19	c.C3217T	p.L1073F	LYPSRKKVPVKDLPPFGINSPQALK	LYPSRKKVPVKDFPPFGINSPQALK	10.0	3.0	-	-	4000_4:160268138-160268138 C>T_LYPSRKKVPVKDFPPFGINSPQALK	0.0
5:33458677-33458677 G>A	0.0	4298	COLORECTAL	-	-	-	-	TARS	uc003jhz.4,p.E227K|ENST00000455217,p.E364K|NM_001258437,p.E331K|uc031sja.1,p.E331K|uc011cod.3,p.E210K|uc011coc.3,p.E364K|ENST00000541634,p.E227K|NM_152295,p.E331K|ENST00000414361,p.E210K|uc010iup.2,p.E272K|NM_001258438,p.E364K|ENST00000265112,p.E331K|ENST00000502553,p.E331K|uc003jhy.4,p.E331K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031sja.1	nonsynonymous SNV	exon11	c.G991A	p.E331K	KNRDHRKIGRDQELYFFHELSPGSC	KNRDHRKIGRDQKLYFFHELSPGSC	9.0	6.0	-	-	4298_5:33458677-33458677 G>A_KNRDHRKIGRDQKLYFFHELSPGSC	0.0
4:108868543-108868543 G>A	1.0	3775	CERVICAL	-	-	-	-	CYP2U1	uc003hyp.3,p.E380K|ENST00000508453,p.E171K|ENST00000332884,p.E380K|NM_183075,p.E380K|uc011cfi.2,p.E171K	protein_coding, processed_transcript	uc011cfi.2	nonsynonymous SNV	exon5	c.G511A	p.E171K	MSLNPDVQEKVHEEIERVIGANRAP	MSLNPDVQEKVHKEIERVIGANRAP	6.0	8.0	-	-	3775_4:108868543-108868543 G>A_MSLNPDVQEKVHKEIERVIGANRAP	0.0
19:1805932-1805932 G>A	0.0	4278	COLORECTAL	-	-	-	-	ATP8B3	ENST00000310127,p.T259M|NM_001178002,p.T206M|NM_138813,p.T259M|ENST00000526092,p.T206M|uc002ltz.2,p.T206M|uc002ltw.4,p.T259M|uc002ltv.4,p.T206M|ENST00000539485,p.T259M|ENST00000525591,p.T206M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ltz.2	nonsynonymous SNV	exon9	c.C617T	p.T206M	NIVPADMLLLASTEPSSLCYVETVD	NIVPADMLLLASMEPSSLCYVETVD	3.0	7.0	-	-	4278_19:1805932-1805932 G>A_NIVPADMLLLASMEPSSLCYVETVD	0.0
11:62366007-62366007 C>T	0.0	4316	COLORECTAL	-	-	-	-	MTA2	NM_004739,p.A99T|uc001ntq.2,p.A99T|ENST00000278823,p.A99T	retained_intron, protein_coding	uc001ntq.2	nonsynonymous SNV	exon4	c.G295A	p.A99T	ELFLSRQFESLPATHIRGKCSVTLL	ELFLSRQFESLPTTHIRGKCSVTLL	9.0	1.0	-	-	4316_11:62366007-62366007 C>T_ELFLSRQFESLPTTHIRGKCSVTLL	0.0
19:42085967-42085967 A>G	0.0	4335	COLORECTAL	-	-	-	-	CEACAM21	NM_001098506,p.K229R|NM_001288773,p.K101R|uc002ore.4,p.K229R|ENST00000407170,p.K101R|ENST00000401445,p.K229R	protein_coding, processed_transcript, nonsense_mediated_decay	uc002ore.4	nonsynonymous SNV	exon3	c.A686G	p.K229R	SNPVSSNRSDPLKLTVKSDDNTLGI	SNPVSSNRSDPLRLTVKSDDNTLGI	7.0	3.0	-	-	4335_19:42085967-42085967 A>G_SNPVSSNRSDPLRLTVKSDDNTLGI	0.0
18:10773532-10773532 C>T	0.0	3713	MELANOMA	-	-	-	-	PIEZO2	uc002kos.2,p.G863E|ENST00000383408,p.G151E|ENST00000302079,p.G863E|ENST00000580640,p.G888E|ENST00000503781,p.G863E|uc002kou.2,p.G217E|NM_022068,p.G863E|ENST00000582913,p.G877E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kou.2	nonsynonymous SNV	exon6	c.G650A	p.G217E	LEKPEVRKLAEPGEEKLEGYSEKAQ	LEKPEVRKLAEPEEEKLEGYSEKAQ	2.0	2.0	-	-	3713_18:10773532-10773532 C>T_LEKPEVRKLAEPEEEKLEGYSEKAQ	0.0
14:64518903-64518903 C>T	1.0	3713	MELANOMA	-	-	-	-	SYNE2	NM_182914,p.P2758S|uc021ruh.1,p.P2791S|ENST00000554584,p.P2791S|ENST00000358025,p.P2758S|NM_015180,p.P2758S|uc001xgm.3,p.P2758S|ENST00000344113,p.P2758S|uc001xgl.3,p.P2758S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ruh.1	nonsynonymous SNV	exon48	c.C8371T	p.P2791S	LLGELNPSIPLLPDDILSQIRKCKV	LLGELNPSIPLLSDDILSQIRKCKV	10.0	9.0	-	-	3713_14:64518903-64518903 C>T_LLGELNPSIPLLSDDILSQIRKCKV	0.0
10:70856957-70856957 A>C	0.0	4335	COLORECTAL	-	-	-	-	SRGN	uc001joz.3,p.K66T|NM_002727,p.K66T|ENST00000242465,p.K66T	protein_coding, processed_transcript	uc001joz.3	nonsynonymous SNV	exon2	c.A197C	p.K66T	GPMFELLPGESNKIPRLRTDLFPKT	GPMFELLPGESNTIPRLRTDLFPKT	10.0	3.0	-	-	4335_10:70856957-70856957 A>C_GPMFELLPGESNTIPRLRTDLFPKT	0.0
5:14419919-14419919 C>G	0.0	4186	BREAST	-	-	-	-	TRIO	ENST00000344204,p.I1664M|ENST00000513206,p.I1397M|uc003jfh.1,p.I1313M|uc003jff.3,p.I1664M|ENST00000537187,p.I1664M|ENST00000512070,p.I1605M|NM_007118,p.I1664M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jfh.1	nonsynonymous SNV	exon29	c.C3939G	p.I1313M	DKLSGGCELTVVIHDFTACNSNELT	DKLSGGCELTVVMHDFTACNSNELT	7.0	7.0	-	-	4186_5:14419919-14419919 C>G_DKLSGGCELTVVMHDFTACNSNELT	0.0
1:231473431-231473431 C>T	1.0	4110	BILE DUCT	-	-	-	-	EXOC8	uc001huq.3,p.G21S|ENST00000360394,p.G21S|NM_175876,p.G21S|ENST00000366645,p.G17S	protein_coding	uc001huq.3	nonsynonymous SNV	exon1	c.G61A	p.G21S	GASRLRRQLESGGFEARLYVKQLSQ	GASRLRRQLESGSFEARLYVKQLSQ	7.0	6.0	-	-	4110_1:231473431-231473431 C>T_GASRLRRQLESGSFEARLYVKQLSQ	0.0
9:34723556-34723556 T>G	0.0	4160	COLORECTAL	-	-	-	-	FAM205A	uc011lor.2,p.K1227N|NM_001141917,p.K1227N|ENST00000378788,p.K1227N	protein_coding	uc011lor.2	nonsynonymous SNV	exon4	c.A3681C	p.K1227N	IKCFLQHINPKTKGKGHEDSMFSAA	IKCFLQHINPKTNGKGHEDSMFSAA	1.0	7.0	-	-	4160_9:34723556-34723556 T>G_IKCFLQHINPKTNGKGHEDSMFSAA	0.0
1:28858494-28858494 A>C	1.0	4037	NSCLC	-	-	-	-	RCC1	uc001bqg.2,p.S85R|ENST00000430407,p.S85R|ENST00000411533,p.S102R|NM_001269,p.S85R|NM_001048195,p.S102R|uc001bqb.2,p.S85R|NM_001048194,p.S116R|NM_001048199,p.S85R|uc001bqa.2,p.S85R|ENST00000373833,p.S85R|ENST00000419074,p.S85R|ENST00000373831,p.S116R|uc001bqf.2,p.S116R|uc001bqc.2,p.S85R|ENST00000427469,p.S85R|ENST00000373832,p.S85R|ENST00000398958,p.S85R|ENST00000434290,p.S93R|uc001bqe.2,p.S102R	retained_intron, protein_coding, nonsense_mediated_decay	uc001bqg.2	nonsynonymous SNV	exon3	c.A253C	p.S85R	EAGGMHTVCLSKSGQVYSFGCNDEG	EAGGMHTVCLSKRGQVYSFGCNDEG	9.0	6.0	-	-	4037_1:28858494-28858494 A>C_EAGGMHTVCLSKRGQVYSFGCNDEG	0.0
7:34097674-34097674 G>A	1.0	4284	COLORECTAL	-	-	-	-	BMPER	uc011kap.2,p.G311R|NM_133468,p.G311R|ENST00000297161,p.G311R|ENST00000426693,p.G311R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kap.2	nonsynonymous SNV	exon11	c.G931A	p.G311R	KVCKFGNKIFQDGEMWSSINCTICA	KVCKFGNKIFQDREMWSSINCTICA	5.0	5.0	-	-	4284_7:34097674-34097674 G>A_KVCKFGNKIFQDREMWSSINCTICA	0.0
1:22970607-22970607 G>T	1.0	4287	COLORECTAL	-	-	-	-	C1QC	uc001bgc.4,p.G31C|NM_172369,p.G31C|uc001bga.4,p.G31C|NM_001114101,p.G31C|ENST00000374637,p.G31C|ENST00000374640,p.G31C|ENST00000374639,p.G31C	protein_coding	uc001bgc.4	nonsynonymous SNV	exon2	c.G91T	p.G31C	LLLLPLRGQANTGCYGIPGMPGLPG	LLLLPLRGQANTCCYGIPGMPGLPG	8.0	8.0	-	-	4287_1:22970607-22970607 G>T_LLLLPLRGQANTCCYGIPGMPGLPG	0.0
9:27192561-27192561 C>T	0.0	2556	MELANOMA	-	-	ID=COSM136706,COSM136705;OCCURENCE=1(skin)	-	TEK	NM_000459,p.R522C|ENST00000406359,p.R479C|ENST00000519080,p.R332C|NM_001290078,p.R375C|uc003zqi.4,p.R522C|ENST00000519097,p.R375C|ENST00000380036,p.R522C|uc003zqj.1,p.R456C|uc011lnp.2,p.R375C|uc011lno.2,p.R479C|NM_001290077,p.R479C	protein_coding, nonsense_mediated_decay	uc011lnp.2	nonsynonymous SNV	exon9	c.C1123T	p.R375C	RTEYELCVQLVRRGEGGEGHPGPVR	RTEYELCVQLVRCGEGGEGHPGPVR	2.0	10.0	-	-	2556_9:27192561-27192561 C>T_RTEYELCVQLVRCGEGGEGHPGPVR	0.0
13:95726528-95726528 C>A	1.0	4281	COLORECTAL	-	-	-	-	ABCC4	ENST00000376887,p.D953Y|ENST00000412704,p.D906Y|NM_001301829,p.D906Y|uc010afk.3,p.D906Y|NM_005845,p.D953Y|uc001vmd.4,p.D953Y	protein_coding, processed_transcript	uc010afk.3	nonsynonymous SNV	exon22	c.G2716T	p.D906Y	FLTTSRWFAVRLDAICAMFVIIVAF	FLTTSRWFAVRLYAICAMFVIIVAF	7.0	6.0	-	-	4281_13:95726528-95726528 C>A_FLTTSRWFAVRLYAICAMFVIIVAF	0.0
10:1406016-1406016 C>T	0.0	3795	MELANOMA	-	-	-	-	ADARB2	NM_018702,p.G95D|ENST00000381312,p.G95D|uc009xhq.3,p.G95D	protein_coding, processed_transcript	uc009xhq.3	nonsynonymous SNV	exon3	c.G284A	p.G95D	PPSGDRARGGAPGAKRKRPLEEGNG	PPSGDRARGGAPDAKRKRPLEEGNG	1.0	10.0	-	-	3795_10:1406016-1406016 C>T_PPSGDRARGGAPDAKRKRPLEEGNG	0.0
18:43310340-43310340 G>A	1.0	3466	MELANOMA	-	-	-	-	SLC14A1	ENST00000589891,p.E75K|uc002lbj.4,p.E75K|ENST00000586951,p.E19K|NM_001146037,p.E75K|ENST00000586142,p.E19K|ENST00000436407,p.E75K|uc021ujg.1,p.E19K|ENST00000586056,p.E19K|ENST00000321925,p.E19K|ENST00000588179,p.E75K|ENST00000589700,p.E19K|uc002lbf.4,p.E19K|NM_001146036,p.E19K|ENST00000415427,p.E75K|uc010xcn.2,p.E19K|uc010dnk.3,p.E75K|NM_001128588,p.E75K|uc002lbk.4,p.E19K|NM_015865,p.E19K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ujg.1	nonsynonymous SNV	exon1	c.G55A	p.E19K	MVRVDSPTMVRGENQVSPCQGRRCF	MVRVDSPTMVRGKNQVSPCQGRRCF	4.0	6.0	-	-	3466_18:43310340-43310340 G>A_MVRVDSPTMVRGKNQVSPCQGRRCF	0.0
7:127991494-127991494 G>A	0.0	3998	MELANOMA	-	-	-	-	PRRT4	uc022aky.1,p.P706S|NM_001174164,p.P706S|ENST00000535159,p.P706S|ENST00000446477,p.P706S|ENST00000435512,p.P500S	protein_coding	uc022aky.1	nonsynonymous SNV	exon6	c.C2116T	p.P706S	CRGFEGAAANPAPSPASSPCSDYTV	CRGFEGAAANPASSPASSPCSDYTV	1.0	9.0	-	-	3998_7:127991494-127991494 G>A_CRGFEGAAANPASSPASSPCSDYTV	0.0
14:70512765-70512765 G>A	0.0	3998	MELANOMA	-	-	-	-	SLC8A3	ENST00000534137,p.R892C|uc001xlv.3,p.R266C|ENST00000357887,p.R893C|NM_001130417,p.R266C|ENST00000216568,p.R266C|uc001xlw.3,p.R892C|uc001xlx.3,p.R893C|NM_182932,p.R889C|ENST00000381269,p.R895C|NM_182936,p.R252C|ENST00000356921,p.R889C|uc001xly.3,p.R895C|uc001xlu.3,p.R252C|NM_058240,p.R892C|ENST00000528359,p.R893C|ENST00000394330,p.R252C|uc001xlz.3,p.R889C|NM_183002,p.R895C|NM_033262,p.R893C	protein_coding, processed_transcript, nonsense_mediated_decay	uc001xlz.3	nonsynonymous SNV	exon7	c.C2665T	p.R889C	RRPHLGGELGGPRGCKLATTWLFVS	RRPHLGGELGGPCGCKLATTWLFVS	1.0	10.0	-	-	3998_14:70512765-70512765 G>A_RRPHLGGELGGPCGCKLATTWLFVS	0.0
5:172745038-172745038 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1696765;OCCURENCE=1(skin)	-	STC2	NM_003714,p.E241K|uc003mco.1,p.E241K|uc003mcn.1,p.E156K|ENST00000265087,p.E241K	retained_intron, protein_coding, processed_transcript	uc003mco.1	nonsynonymous SNV	exon4	c.G721A	p.E241K	VDRTKLSRAHHGEAGHHLPEPSSRE	VDRTKLSRAHHGKAGHHLPEPSSRE	2.0	9.0	-	-	3713_5:172745038-172745038 C>T_VDRTKLSRAHHGKAGHHLPEPSSRE	0.0
1:104078042-104078042 C>G	1.0	4278	COLORECTAL	-	-	-	-	RNPC3	ENST00000423855,p.S178R|uc010oum.1,p.S178R|ENST00000527062,p.S19R|ENST00000524631,p.S178R|NM_017619,p.S178R|uc010oul.1,p.S178R|ENST00000533099,p.S178R|uc010oun.2,p.S178R	retained_intron, protein_coding, nonsense_mediated_decay	uc010oun.2	nonsynonymous SNV	exon5	c.C534G	p.S178R	STILANIVNALASVPKFYVQVLHLM	STILANIVNALARVPKFYVQVLHLM	8.0	9.0	-	-	4278_1:104078042-104078042 C>G_STILANIVNALARVPKFYVQVLHLM	0.0
10:51226216-51226216 C>T	1.0	4298	COLORECTAL	-	-	-	-	PARG	uc009xom.4,p.G171S|uc021pqg.2,p.G256S|ENST00000602930,p.G240S|ENST00000425119,p.G256S|uc001jik.4,p.G240S|uc001jij.4,p.G256S|uc010qgy.3,p.G279S	protein_coding, processed_transcript	uc021pqg.2	nonsynonymous SNV	exon7	c.G766A	p.G256S	KAPENHADTIGSGRAIPIKQGMLLK	KAPENHADTIGSSRAIPIKQGMLLK	10.0	9.0	-	-	4298_10:51226216-51226216 C>T_KAPENHADTIGSSRAIPIKQGMLLK	0.0
2:206874448-206874448 G>T	1.0	4281	COLORECTAL	-	-	-	-	INO80D	NM_017759,p.T538N|ENST00000403263,p.T538N|uc002vaz.4,p.T538N	protein_coding	uc002vaz.4	nonsynonymous SNV	exon9	c.C1613A	p.T538N	VQHQQQRKPRKKTKPPALTKKHKKK	VQHQQQRKPRKKNKPPALTKKHKKK	7.0	5.0	-	-	4281_2:206874448-206874448 G>T_VQHQQQRKPRKKNKPPALTKKHKKK	0.0
X:47836418-47836418 T>C	0.0	4287	COLORECTAL	-	-	-	-	ZNF182	NM_006962,p.I356M|ENST00000305127,p.I356M|NM_001178099,p.I356M|ENST00000396965,p.I356M|uc004dit.3,p.I356M|NM_001007088,p.I337M|uc004dir.3,p.I356M|ENST00000376943,p.I337M|uc004dis.3,p.I337M	protein_coding	uc004dit.3	nonsynonymous SNV	exon7	c.A1068G	p.I356M	KTYECTKCGESFIQKLDLIIHHSTH	KTYECTKCGESFMQKLDLIIHHSTH	5.0	9.0	-	-	4287_X:47836418-47836418 T>C_KTYECTKCGESFMQKLDLIIHHSTH	0.0
18:9360052-9360052 A>C	0.0	4320	COLORECTAL	-	-	-	-	TWSG1	NM_020648,p.E69A|uc002knz.3,p.E69A|ENST00000262120,p.E69A|ENST00000581641,p.E69A	protein_coding, nonsense_mediated_decay	uc002knz.3	nonsynonymous SNV	exon3	c.A206C	p.E69A	KECMLCLGALWDECCDCVGMCNPRN	KECMLCLGALWDACCDCVGMCNPRN	8.0	3.0	-	-	4320_18:9360052-9360052 A>C_KECMLCLGALWDACCDCVGMCNPRN	0.0
2:208434965-208434965 C>A	1.0	4266	COLORECTAL	-	-	-	1	CREB1	ENST00000539789,p.S116Y|ENST00000421139,p.S102Y|ENST00000430624,p.S142Y|ENST00000353267,p.S142Y|uc002vcd.3,p.S142Y|uc002vcc.3,p.S156Y|NM_004379,p.S142Y|ENST00000457101,p.S116Y|NM_134442,p.S156Y|ENST00000536726,p.S142Y|ENST00000432329,p.S156Y|ENST00000445803,p.S156Y|uc010ziz.1,p.S140Y|ENST00000448277,p.S102Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ziz.1	nonsynonymous SNV	exon5	c.C419A	p.S140Y	DAPGVPRIEEEKSEEETSAPAITTV	DAPGVPRIEEEKYEEETSAPAITTV	9.0	8.0	-	-	4266_2:208434965-208434965 C>A_DAPGVPRIEEEKYEEETSAPAITTV	0.0
17:15975524-15975524 A>G	1.0	4180	BREAST	-	-	-	1	NCOR1	uc002gpp.1,p.L1184S|NM_006311,p.L1277S|uc002gpo.3,p.L1277S|ENST00000395851,p.L1293S|ENST00000268712,p.L1277S|uc010coy.3,p.L185S|uc010vwc.2,p.L88S|NM_001190440,p.L1293S|uc002gpn.3,p.L1293S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vwc.2	nonsynonymous SNV	exon5	c.T263C	p.L88S	VSAPLEGLICRALPRGSPHSDLKER	VSAPLEGLICRASPRGSPHSDLKER	10.0	9.0	-	-	4180_17:15975524-15975524 A>G_VSAPLEGLICRASPRGSPHSDLKER	0.0
3:62388817-62388817 G>A	0.0	4326	BREAST	-	-	-	-	CADPS	uc021wzv.1,p.T1265M|uc003dln.2,p.T1195M|uc003dlm.2,p.T1235M|NM_003716,p.T1274M|uc003dlj.1,p.T229M|ENST00000283269,p.T1235M|NM_183394,p.T1235M|uc003dll.2,p.T1274M|uc003dlk.1,p.T722M|ENST00000383710,p.T1274M|NM_183393,p.T1195M|ENST00000357948,p.T1195M	retained_intron, protein_coding, processed_transcript	uc021wzv.1	nonsynonymous SNV	exon27	c.C3794T	p.T1265M	YNSSMNVICTWLTDRMDLQLHIYQL	YNSSMNVICTWLMDRMDLQLHIYQL	3.0	10.0	-	-	4326_3:62388817-62388817 G>A_YNSSMNVICTWLMDRMDLQLHIYQL	0.0
9:5968247-5968247 C>A	1.0	4046	OVARIAN	-	-	-	-	KIAA2026	NM_001017969,p.D662Y|ENST00000513355,p.D595Y|uc003zjq.4,p.D662Y|ENST00000381461,p.D662Y|ENST00000399933,p.D662Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc003zjq.4	nonsynonymous SNV	exon3	c.G1984T	p.D662Y	DHPEINCHKVVRDILLEQSLQSHKK	DHPEINCHKVVRYILLEQSLQSHKK	6.0	3.0	-	-	4046_9:5968247-5968247 C>A_DHPEINCHKVVRYILLEQSLQSHKK	0.0
1:152732884-152732884 C>T	0.0	4149	OVARIAN	-	-	-	-	KPRP	NM_001025231,p.R274C|ENST00000606109,p.R274C|uc021ozf.1,p.R274C|ENST00000368773,p.R274C|uc001fal.1,p.R274C	protein_coding	uc021ozf.1	nonsynonymous SNV	exon1	c.C820T	p.R274C	LQLFPRSCSPPRRFEPCSSSYLPLR	LQLFPRSCSPPRCFEPCSSSYLPLR	1.0	2.0	-	-	4149_1:152732884-152732884 C>T_LQLFPRSCSPPRCFEPCSSSYLPLR	0.0
3:172098882-172098882 A>T	1.0	4317	COLORECTAL	-	-	-	-	FNDC3B	ENST00000336824,p.Q1101L|NM_001135095,p.Q1101L|ENST00000416957,p.Q1101L|uc003fhz.4,p.Q1101L|NM_022763,p.Q1101L|uc003fhy.3,p.Q1101L|ENST00000415807,p.Q1101L	retained_intron, protein_coding, processed_transcript	uc003fhz.4	nonsynonymous SNV	exon25	c.A3302T	p.Q1101L	LQVLVGRESEYKQVYKGEEATFQIS	LQVLVGRESEYKLVYKGEEATFQIS	10.0	4.0	-	-	4317_3:172098882-172098882 A>T_LQVLVGRESEYKLVYKGEEATFQIS	0.0
12:51502999-51502999 G>A	1.0	4345	COLORECTAL	-	-	-	-	TFCP2	uc009zly.1,p.P110S|ENST00000257915,p.P208S|ENST00000549867,p.P208S|ENST00000548108,p.P110S|NM_005653,p.P208S|uc001rxv.2,p.P208S|NM_001173452,p.P208S|uc001rxw.3,p.P208S	retained_intron, protein_coding	uc009zly.1	nonsynonymous SNV	exon6	c.C328T	p.P110S	FTMRKHGGEKGVPFRVQIDTFKENE	FTMRKHGGEKGVSFRVQIDTFKENE	7.0	10.0	-	-	4345_12:51502999-51502999 G>A_FTMRKHGGEKGVSFRVQIDTFKENE	0.0
12:124311343-124311343 T>A	0.0	4298	COLORECTAL	-	-	-	-	DNAH10	ENST00000409039,p.V1312D|uc001uft.4,p.V1312D|NM_207437,p.V1312D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001uft.4	nonsynonymous SNV	exon24	c.T3935A	p.V1312D	GFLRALRKLPRPVRGLSVTYYLEAK	GFLRALRKLPRPDRGLSVTYYLEAK	3.0	2.0	-	-	4298_12:124311343-124311343 T>A_GFLRALRKLPRPDRGLSVTYYLEAK	0.0
16:49660144-49660146 TGA>-	0.0	4335	COLORECTAL	-	-	-	-	ZNF423	ENST00000567169,p.1054_1055del|ENST00000561648,p.1171_1172del|ENST00000535559,p.1054_1055del|ENST00000262383,p.1171_1172del|ENST00000562520,p.1111_1112del|uc010vgn.3,p.1054_1055del|uc031qwe.1,p.1111_1112del|uc031qwd.1,p.1171_1172del|NM_015069,p.1171_1172del|ENST00000563137,p.1111_1112del|ENST00000562871,p.1111_1112del|NM_001271620,p.1111_1112del	retained_intron, protein_coding	uc031qwe.1	nonframeshift deletion	exon5	c.3332_3334del	p.1111_1112del	TSPVPRKKTYQCIKCQMTFENEREIQ	TSPVPRKKTYQCKCQMTFENEREIQ	5.0	9.0	-	-	4335_16:49660144-49660146 TGA>-_TSPVPRKKTYQCKCQMTFENEREIQ	0.0
3:48677616-48677616 C>G	1.0	4196	COLORECTAL	-	-	-	-	CELSR3	ENST00000544264,p.M3139I|uc003cul.3,p.M3134I|NM_001407,p.M3134I|uc010hkf.3,p.M424I|ENST00000164024,p.M3134I|uc003cuf.1,p.M3232I|uc010hkg.3,p.M1117I	retained_intron, protein_coding	uc010hkg.3	nonsynonymous SNV	exon24	c.G3351C	p.M1117I	PRRQPPRDYPGAMAGRFGSRDALDL	PRRQPPRDYPGAIAGRFGSRDALDL	6.0	6.0	-	-	4196_3:48677616-48677616 C>G_PRRQPPRDYPGAIAGRFGSRDALDL	0.0
11:108550129-108550129 G>A	1.0	3919	MELANOMA	-	-	-	1	DDX10	ENST00000526794,p.M230I|uc001pkm.3,p.M230I|ENST00000322536,p.M230I|uc001pkl.1,p.M230I|NM_004398,p.M230I	retained_intron, protein_coding, processed_transcript	uc001pkm.3	nonsynonymous SNV	exon6	c.G690A	p.M230I	MLVLDEADRILDMGFADTMNAVIEN	MLVLDEADRILDIGFADTMNAVIEN	6.0	9.0	-	-	3919_11:108550129-108550129 G>A_MLVLDEADRILDIGFADTMNAVIEN	0.0
X:19606777-19606777 G>A	1.0	3713	MELANOMA	-	-	-	-	SH3KBP1	ENST00000379726,p.P408S|uc004czm.3,p.P428S|uc011mjf.2,p.P190S|uc011mje.2,p.P167S|NM_001184960,p.P190S|NM_001024666,p.P391S|uc004czl.3,p.P391S|ENST00000379698,p.P391S|ENST00000541422,p.P167S|NM_031892,p.P428S|ENST00000397821,p.P428S|ENST00000379716,p.P190S	protein_coding, processed_transcript	uc011mjf.2	nonsynonymous SNV	exon7	c.C568T	p.P190S	ALPPRRPERPVGPLTHTRGDSPKID	ALPPRRPERPVGSLTHTRGDSPKID	8.0	7.0	-	-	3713_X:19606777-19606777 G>A_ALPPRRPERPVGSLTHTRGDSPKID	0.0
11:59426888-59426888 G>C	1.0	4071	COLORECTAL	-	-	-	-	PATL1	uc001noe.4,p.P61R|NM_152716,p.P61R|uc009yms.1,p.P61R|ENST00000300146,p.P61R	retained_intron, protein_coding	uc009yms.1	nonsynonymous SNV	exon3	c.C182G	p.P61R	AHERLAELEEKLPVAVNEQTGNGER	AHERLAELEEKLRVAVNEQTGNGER	8.0	5.0	-	-	4071_11:59426888-59426888 G>C_AHERLAELEEKLRVAVNEQTGNGER	0.0
2:197711869-197711869 C>A	0.0	4126	NSCLC	-	-	-	-	PGAP1	NM_024989,p.V670F|uc002utw.3,p.V670F|ENST00000354764,p.V670F|uc002utx.3,p.V496F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002utx.3	nonsynonymous SNV	exon23	c.G1486T	p.V496F	LWDVLLLPELDAVILTCQSMCFPLI	LWDVLLLPELDAFILTCQSMCFPLI	2.0	6.0	-	-	4126_2:197711869-197711869 C>A_LWDVLLLPELDAFILTCQSMCFPLI	0.0
17:5087377-5087377 G>A	1.0	3879	MELANOMA	-	-	-	-	ZNF594	NM_032530,p.L59F|ENST00000575779,p.L59F|ENST00000576772,p.L59F|ENST00000399604,p.L59F|uc010cla.1,p.L59F|uc021tol.1,p.L59F	protein_coding	uc021tol.1	nonsynonymous SNV	exon1	c.C175T	p.L59F	HWVSPLKDAMRHLPSQESGIREMHI	HWVSPLKDAMRHFPSQESGIREMHI	5.0	10.0	-	-	3879_17:5087377-5087377 G>A_HWVSPLKDAMRHFPSQESGIREMHI	0.0
7:18705926-18705926 G>A	1.0	3713	MELANOMA	-	-	-	-	HDAC9	ENST00000405010,p.E517K|uc003suh.3,p.E517K|NM_001204145,p.E473K|ENST00000441542,p.E520K|uc003suf.2,p.E548K|ENST00000432645,p.E517K|NM_178423,p.E517K|uc011jyf.2,p.E440K|NM_001204148,p.E489K|uc003sui.3,p.E520K|uc003sud.2,p.E517K|uc011jye.2,p.E489K|NM_178425,p.E520K|NM_001204144,p.E515K|ENST00000417496,p.E515K|uc011jyd.2,p.E517K|uc010kud.2,p.E520K|uc003sue.3,p.E517K|uc003suj.3,p.E476K|uc011jyc.2,p.E476K|ENST00000456174,p.E489K|ENST00000406451,p.E517K|uc011jya.2,p.E515K|NM_001204147,p.E440K|uc003sua.1,p.E495K|uc011jyb.2,p.E473K|NM_014707,p.E517K|ENST00000524023,p.E440K|NM_058176,p.E517K|ENST00000401921,p.E476K|NM_001204146,p.E476K|ENST00000428307,p.E473K|ENST00000406072,p.E504K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jyf.2	nonsynonymous SNV	exon10	c.G1318A	p.E440K	AEEELQGDQAMQEDRAPSSGNSTRS	AEEELQGDQAMQKDRAPSSGNSTRS	6.0	6.0	-	-	3713_7:18705926-18705926 G>A_AEEELQGDQAMQKDRAPSSGNSTRS	0.0
15:48063206-48063206 C>A	0.0	4129	NSCLC	-	-	-	-	SEMA6D	ENST00000389433,p.H797N|ENST00000389428,p.H741N|ENST00000358066,p.H754N|ENST00000537942,p.H754N|ENST00000389432,p.H773N|ENST00000316364,p.H816N|uc001zwb.3,p.H754N|uc001zvw.3,p.H754N|uc001zvy.3,p.H816N|ENST00000558014,p.H754N|NM_153618,p.H816N|uc001zwc.3,p.H741N|NM_020858,p.H754N|ENST00000354744,p.H760N|uc010bek.3,p.H816N|ENST00000536845,p.H816N|NM_153617,p.H760N|uc001zvz.3,p.H760N|NM_153616,p.H741N|NM_001198999,p.H754N	retained_intron, protein_coding	uc010bek.3	nonsynonymous SNV	exon19	c.C2446A	p.H816N	ETPQFFPSSPPPHSPLSHGHIPSAI	ETPQFFPSSPPPNSPLSHGHIPSAI	4.0	4.0	-	-	4129_15:48063206-48063206 C>A_ETPQFFPSSPPPNSPLSHGHIPSAI	0.0
3:164714412-164714412 T>G	0.0	4258	ENDOMETRIAL	-	-	-	-	SI	uc003fei.3,p.N1535H|NM_001041,p.N1535H|ENST00000264382,p.N1535H	retained_intron, protein_coding, nonsense_mediated_decay	uc003fei.3	nonsynonymous SNV	exon40	c.A4603C	p.N1535H	MSYTGADICGFFNNSEYHLCTRWMQ	MSYTGADICGFFHNSEYHLCTRWMQ	1.0	5.0	-	-	4258_3:164714412-164714412 T>G_MSYTGADICGFFHNSEYHLCTRWMQ	0.0
8:23538897-23538897 C>T	1.0	3713	MELANOMA	-	-	-	-	NKX3-1	NM_006167,p.R181Q|uc031tao.1,p.R106Q|ENST00000380871,p.R181Q|uc011kzx.2,p.R181Q|ENST00000523261,p.R106Q|NM_001256339,p.R106Q	protein_coding	uc031tao.1	nonsynonymous SNV	exon3	c.G317A	p.R106Q	KIWFQNRRYKTKRKQLSSELGDLEK	KIWFQNRRYKTKQKQLSSELGDLEK	2.0	3.0	-	-	3713_8:23538897-23538897 C>T_KIWFQNRRYKTKQKQLSSELGDLEK	0.0
6:125379178-125379178 G>A	1.0	3466	MELANOMA	-	-	-	-	RNF217	NM_152553,p.D111N|ENST00000521654,p.D403N|uc003pzr.3,p.D168N|ENST00000359704,p.D111N|uc003pzs.3,p.D111N|ENST00000275184,p.D47N|NM_001286398,p.D403N|ENST00000560949,p.D168N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003pzs.3	nonsynonymous SNV	exon5	c.G331A	p.D111N	HEGVNCKEYKKGDKLLRHWASEIEH	HEGVNCKEYKKGNKLLRHWASEIEH	8.0	9.0	-	-	3466_6:125379178-125379178 G>A_HEGVNCKEYKKGNKLLRHWASEIEH	0.0
1:46810807-46810807 C>T	1.0	2556	MELANOMA	-	-	-	-	NSUN4	NM_001256128,p.P94L|uc001cpr.2,p.P143L|ENST00000537428,p.P94L|uc009vyg.2,p.P94L|NM_199044,p.P143L|uc010omc.2,p.P94L|ENST00000474844,p.P143L|uc031pml.1,p.P94L|NM_001256127,p.P94L|ENST00000536062,p.P94L	protein_coding, processed_transcript, nonsense_mediated_decay	uc031pml.1	nonsynonymous SNV	exon2	c.C281T	p.P94L	CFTFDRGDISRFPPARPGSLGVMEY	CFTFDRGDISRFLPARPGSLGVMEY	7.0	5.0	-	-	2556_1:46810807-46810807 C>T_CFTFDRGDISRFLPARPGSLGVMEY	0.0
19:16612234-16612234 C>T	1.0	3879	MELANOMA	-	-	-	-	C19orf44	ENST00000221671,p.P211S|uc002neh.1,p.P211S|uc002nef.1,p.P211S|ENST00000596592,p.P211S|ENST00000593380,p.P211S|ENST00000594035,p.P211S|NM_001288834,p.P211S|NM_032207,p.P211S|uc002neg.3,p.P211S	protein_coding, nonsense_mediated_decay	uc002neh.1	nonsynonymous SNV	exon2	c.C631T	p.P211S	PKQKEPARTFDSPDSDEEEMKVLLG	PKQKEPARTFDSSDSDEEEMKVLLG	7.0	6.0	-	-	3879_19:16612234-16612234 C>T_PKQKEPARTFDSSDSDEEEMKVLLG	0.0
3:171329396-171329396 G>A	1.0	3713	MELANOMA	-	-	-	-	PLD1	ENST00000340989,p.P971S|uc003fhu.4,p.P265S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003fhu.4	nonsynonymous SNV	exon8	c.C793T	p.P265S	CFRSKMTPGVEDP	CFRSKMTPGVEDS	6.0	7.0	-	-	3713_3:171329396-171329396 G>A_CFRSKMTPGVEDS	0.0
17:25930892-25930892 C>T	1.0	4317	COLORECTAL	-	-	-	-	KSR1	ENST00000509603,p.P515S|ENST00000398982,p.P250S|uc002gzm.3,p.P179S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002gzm.3	nonsynonymous SNV	exon7	c.C535T	p.P179S	PDISAFAHAAPLPEAADGTRLDDQP	PDISAFAHAAPLSEAADGTRLDDQP	10.0	9.0	-	-	4317_17:25930892-25930892 C>T_PDISAFAHAAPLSEAADGTRLDDQP	0.0
6:42185574-42185574 G>A	1.0	4284	COLORECTAL	-	-	-	-	MRPS10	NM_018141,p.T5I|ENST00000053468,p.T5I|uc003osa.4,p.T5I	protein_coding	uc003osa.4	nonsynonymous SNV	exon1	c.C14T	p.T5I	MAARTAFGAVCRRLWQG	MAARIAFGAVCRRLWQG	7.0	8.0	-	-	4284_6:42185574-42185574 G>A_MAARIAFGAVCRRLWQG	0.0
2:179470369-179470369 C>T	1.0	4000	MELANOMA	-	-	-	-	TTN	uc021vtb.2,p.E8820K|NM_133437,p.E9012K|uc031rqc.1,p.E17885K|ENST00000359218,p.E8945K|NM_001256850,p.E16244K|NM_133432,p.E8945K|NM_133378,p.E15317K|NM_001267550,p.E17885K|uc021vsz.2,p.E9012K|NM_003319,p.E8820K|ENST00000342175,p.E9012K|uc021vta.2,p.E8945K|ENST00000460472,p.E8820K|ENST00000589042,p.E17885K|uc031rqd.1,p.E16244K|ENST00000591111,p.E16244K|uc021vsy.2,p.E15317K|ENST00000342992,p.E15317K	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon229	c.G48730A	p.E16244K	ERTKSTITLDWKEPRSNGGSPIQGY	ERTKSTITLDWKKPRSNGGSPIQGY	6.0	6.0	-	-	4000_2:179470369-179470369 C>T_ERTKSTITLDWKKPRSNGGSPIQGY	0.0
2:175431828-175431828 G>A	1.0	2556	MELANOMA	-	-	-	-	WIPF1	uc002uiz.3,p.P476S|uc002uja.3,p.P476S|ENST00000392547,p.P476S|ENST00000392546,p.P476S|ENST00000272746,p.P476S|NM_001077269,p.P476S|ENST00000359761,p.P476S|NM_003387,p.P476S|uc010fqt.1,p.P476S	retained_intron, protein_coding, processed_transcript	uc010fqt.1	nonsynonymous SNV	exon7	c.C1426T	p.P476S	PPEPYVQTTKSYPSKLARNESRSGS	PPEPYVQTTKSYSSKLARNESRSGS	10.0	2.0	-	-	2556_2:175431828-175431828 G>A_PPEPYVQTTKSYSSKLARNESRSGS	0.0
8:145727080-145727080 C>T	1.0	4213	COLORECTAL	0.0005	-	ID=COSM3395202;OCCURENCE=1(pancreas)	-	PPP1R16A	uc003zdd.3,p.R461C|NM_032902,p.R461C|uc003zdf.3,p.R461C|ENST00000435887,p.R461C|ENST00000292539,p.R461C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zdf.3	nonsynonymous SNV	exon10	c.C1381T	p.R461C	HDKAHHTLADLKRQRAAAKLQRPPP	HDKAHHTLADLKCQRAAAKLQRPPP	9.0	6.0	-	-	4213_8:145727080-145727080 C>T_HDKAHHTLADLKCQRAAAKLQRPPP	0.0
16:24580822-24580822 A>-	1.0	4326	BREAST	-	-	-	-	RBBP6	NM_018703,p.R903fs|uc002dmi.3,p.R903fs|uc002dmh.3,p.R937fs|uc010vcb.1,p.R804fs|ENST00000564314,p.R804fs|NM_006910,p.R937fs|ENST00000348022,p.R903fs|uc002dmk.3,p.R770fs|ENST00000319715,p.R937fs	retained_intron, protein_coding	uc010vcb.1	frameshift deletion	exon15	c.2412delA	p.R804fs	PGDGKGNKHKKHRKRRKGEESEGFLN	PGDGKGNKHKKHRKEEKGRKVRVF	8.0	5.0	-	-	4326_16:24580822-24580822 A>-_PGDGKGNKHKKHRKEEKGRKVRVF	0.0
8:146015241-146015241 C>T	1.0	4284	COLORECTAL	-	-	-	-	RPL8	uc003zec.3,p.R241H|ENST00000528957,p.R241H|NM_033301,p.R241H|uc003zeb.3,p.R241H|NM_000973,p.R241H|ENST00000533397,p.R220H|ENST00000527914,p.R132H|ENST00000262584,p.R241H|ENST00000394920,p.R241H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zec.3	nonsynonymous SNV	exon6	c.G722A	p.R241H	APAGRKVGLIAARRTGRLRGTKTVQ	APAGRKVGLIAAHRTGRLRGTKTVQ	10.0	3.0	-	-	4284_8:146015241-146015241 C>T_APAGRKVGLIAAHRTGRLRGTKTVQ	0.0
2:70515313-70515313 C>T	1.0	3466	MELANOMA	-	-	-	-	SNRPG	ENST00000454893,p.G23S|ENST00000272348,p.G23S|NM_003096,p.G23S|uc002sgp.3,p.G23S	retained_intron, protein_coding, processed_transcript	uc002sgp.3	nonsynonymous SNV	exon3	c.G67A	p.G23S	KFMDKKLSLKLNGGRHVQGILRGFD	KFMDKKLSLKLNSGRHVQGILRGFD	5.0	2.0	-	-	3466_2:70515313-70515313 C>T_KFMDKKLSLKLNSGRHVQGILRGFD	0.0
2:137814208-137814208 G>A	0.0	4316	COLORECTAL	-	-	-	-	THSD7B	ENST00000272643,p.A120T|ENST00000413152,p.A89T|ENST00000409968,p.A120T|uc002tva.1,p.A89T	retained_intron, protein_coding, processed_transcript	uc002tva.1	nonsynonymous SNV	exon2	c.G265A	p.A89T	VSDWHHCVLVPYARGEVKPRTAECV	VSDWHHCVLVPYTRGEVKPRTAECV	2.0	8.0	-	-	4316_2:137814208-137814208 G>A_VSDWHHCVLVPYTRGEVKPRTAECV	0.0
14:47601040-47601040 T>G	0.0	4281	COLORECTAL	-	-	-	-	MDGA2	ENST00000399232,p.K268Q|uc001wwj.4,p.K268Q|ENST00000439988,p.K199Q|NM_001113498,p.K199Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wwj.4	nonsynonymous SNV	exon5	c.A802C	p.K268Q	EIYEPFFTQGETKILKLKNLRPQDY	EIYEPFFTQGETQILKLKNLRPQDY	2.0	9.0	-	-	4281_14:47601040-47601040 T>G_EIYEPFFTQGETQILKLKNLRPQDY	0.0
2:157182411-157182411 G>A	1.0	4071	COLORECTAL	-	-	-	-	NR4A2	ENST00000409108,p.P513L|ENST00000429376,p.P450L	protein_coding, nonsense_mediated_decay	ENST00000429376	nonsynonymous SNV	exon8	c.C1349T	p.P450L	QRPRDFQQWGVEPPQLFVQTVGEAP	QRPRDFQQWGVELPQLFVQTVGEAP	5.0	2.0	-	-	4071_2:157182411-157182411 G>A_QRPRDFQQWGVELPQLFVQTVGEAP	0.0
3:5244711-5244711 G>A	1.0	2369	MELANOMA	-	-	-	-	EDEM1	ENST00000445686,p.G112S|uc003bqi.3,p.G307S|ENST00000256497,p.G307S|NM_014674,p.G307S|uc021wsl.1,p.G112S|uc011asz.1,p.G85S	retained_intron, protein_coding, nonsense_mediated_decay	uc021wsl.1	nonsynonymous SNV	exon5	c.G334A	p.G112S	PDTNNETCTAGAGSLLVEFGILSRL	PDTNNETCTAGASSLLVEFGILSRL	9.0	6.0	-	-	2369_3:5244711-5244711 G>A_PDTNNETCTAGASSLLVEFGILSRL	0.0
12:125570963-125570963 G>T	1.0	4258	ENDOMETRIAL	-	-	-	-	AACS	ENST00000316519,p.G149V|NM_023928,p.G149V|uc001uhc.3,p.G149V|uc001uhd.3,p.G149V|ENST00000261686,p.G149V	protein_coding, processed_transcript, nonsense_mediated_decay	uc001uhd.3	nonsynonymous SNV	exon4	c.G446T	p.G149V	EVALFAAAMRKMGVKKGDRVVGYLP	EVALFAAAMRKMVVKKGDRVVGYLP	7.0	10.0	-	-	4258_12:125570963-125570963 G>T_EVALFAAAMRKMVVKKGDRVVGYLP	0.0
20:61943064-61943064 G>A	0.0	4240	BREAST	-	-	-	-	COL20A1	ENST00000422202,p.E550K|uc011aav.2,p.E364K|ENST00000358894,p.E543K|NM_020882,p.E543K|ENST00000435874,p.E550K|uc011aau.2,p.E543K|ENST00000326996,p.E543K	retained_intron, protein_coding, processed_transcript	uc011aav.2	nonsynonymous SNV	exon9	c.G1090A	p.E364K	DYEVSVQSLRGPEGSEARGIRARTP	DYEVSVQSLRGPKGSEARGIRARTP	1.0	7.0	-	-	4240_20:61943064-61943064 G>A_DYEVSVQSLRGPKGSEARGIRARTP	0.0
7:7629132-7629132 T>G	1.0	4320	COLORECTAL	-	-	-	-	MIOS	uc003srf.3,p.L661V|uc003srg.3,p.L196V|NM_019005,p.L661V|ENST00000340080,p.L661V|uc010ktq.3,p.L56V|ENST00000405785,p.L661V	retained_intron, protein_coding, processed_transcript	uc010ktq.3	nonsynonymous SNV	exon3	c.T166G	p.L56V	ILLTGLTKDGVDLMESYVDRTGDVQ	ILLTGLTKDGVDVMESYVDRTGDVQ	7.0	1.0	-	-	4320_7:7629132-7629132 T>G_ILLTGLTKDGVDVMESYVDRTGDVQ	0.0
2:220149680-220149680 G>A	1.0	3713	MELANOMA	-	-	-	-	DNAJB2	uc010zlb.1,p.E132K|ENST00000336576,p.E316K|uc002vkx.1,p.E316K|NM_006736,p.E316K	retained_intron, protein_coding, processed_transcript	uc010zlb.1	nonsynonymous SNV	exon4	c.G394A	p.E132K	RGEATKRSPSPEEKASRCLIL	RGEATKRSPSPEKKASRCLIL	9.0	10.0	-	-	3713_2:220149680-220149680 G>A_RGEATKRSPSPEKKASRCLIL	0.0
5:71756834-71756834 G>A	0.0	4235	COLORECTAL	-	-	-	-	ZNF366	ENST00000318442,p.P164S|NM_152625,p.P164S|uc003kce.1,p.P164S	protein_coding, nonsense_mediated_decay	uc003kce.1	nonsynonymous SNV	exon2	c.C490T	p.P164S	QEPIKPSAVWPQPTPTPFLPTPYPY	QEPIKPSAVWPQSTPTPFLPTPYPY	3.0	1.0	-	-	4235_5:71756834-71756834 G>A_QEPIKPSAVWPQSTPTPFLPTPYPY	0.0
22:42525856-42525856 A>G	0.0	4240	BREAST	-	-	-	-	CYP2D6	ENST00000360608,p.V79A|ENST00000359033,p.V79A|ENST00000360124,p.V19A|ENST00000389970,p.V79A|uc003bce.3,p.V79A|uc003bcf.3,p.V79A|NM_000106,p.V79A|NM_001025161,p.V79A	retained_intron, protein_coding, nonsense_mediated_decay	uc003bcf.3	nonsynonymous SNV	exon2	c.T236C	p.V79A	DVFSLQLAWTPVVVLNGLAAVREAL	DVFSLQLAWTPVAVLNGLAAVREAL	5.0	9.0	-	-	4240_22:42525856-42525856 A>G_DVFSLQLAWTPVAVLNGLAAVREAL	0.0
12:133306847-133306847 G>A	1.0	3466	MELANOMA	-	-	-	-	ANKLE2	uc001ukx.2,p.S634F|ENST00000539605,p.S572F|ENST00000357997,p.S634F|NM_015114,p.S634F	retained_intron, protein_coding, processed_transcript	uc001ukx.2	nonsynonymous SNV	exon11	c.C1901T	p.S634F	SCRDKATTSGSNSISVRAFLDEDDM	SCRDKATTSGSNFISVRAFLDEDDM	9.0	5.0	-	-	3466_12:133306847-133306847 G>A_SCRDKATTSGSNFISVRAFLDEDDM	0.0
15:67665763-67665763 C>T	0.0	2591	MELANOMA	-	-	-	-	IQCH	NM_001284348,p.P207L|NM_001031715,p.P455L|ENST00000358767,p.P282L|NM_001284347,p.P203L|uc002aqo.2,p.P455L|uc002aqp.2,p.P207L|ENST00000546225,p.P203L|ENST00000335894,p.P455L|ENST00000360277,p.P207L|uc002aqq.2,p.P203L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002aqq.2	nonsynonymous SNV	exon6	c.C608T	p.P203L	RIRTSRRTIIHIPSLGYSQPVREHI	RIRTSRRTIIHILSLGYSQPVREHI	3.0	8.0	-	-	2591_15:67665763-67665763 C>T_RIRTSRRTIIHILSLGYSQPVREHI	0.0
15:24921210-24921210 G>A	0.0	4149	OVARIAN	-	-	-	-	NPAP1	uc001ywo.3,p.V66I|NM_018958,p.V66I|ENST00000329468,p.V66I	protein_coding	uc001ywo.3	nonsynonymous SNV	exon1	c.G196A	p.V66I	NARRRPSAASIFVAPKRPCPLPRAA	NARRRPSAASIFIAPKRPCPLPRAA	1.0	4.0	-	-	4149_15:24921210-24921210 G>A_NARRRPSAASIFIAPKRPCPLPRAA	0.0
X:83128760-83128760 G>T	0.0	4316	COLORECTAL	-	-	-	-	CYLC1	NM_021118,p.K348N|uc004eei.2,p.K348N|ENST00000329312,p.K348N|uc004eeh.2,p.K347N	protein_coding	uc004eei.2	nonsynonymous SNV	exon4	c.G1044T	p.K348N	ESGDSKDERKDTKKDKKKLKKDDKK	ESGDSKDERKDTNKDKKKLKKDDKK	1.0	10.0	-	-	4316_X:83128760-83128760 G>T_ESGDSKDERKDTNKDKKKLKKDDKK	0.0
2:69555428-69555428 G>A	1.0	4287	COLORECTAL	-	-	-	-	GFPT1	NM_001244710,p.A623V|ENST00000361060,p.A605V|uc002sfh.3,p.A605V|ENST00000357308,p.A623V|NM_002056,p.A605V|uc002sfi.2,p.A623V	protein_coding, processed_transcript	uc002sfi.2	nonsynonymous SNV	exon18	c.C1868T	p.A623V	IMRDHTYAKCQNALQQVVARQGRPV	IMRDHTYAKCQNVLQQVVARQGRPV	10.0	10.0	-	-	4287_2:69555428-69555428 G>A_IMRDHTYAKCQNVLQQVVARQGRPV	0.0
16:1265079-1265079 C>G	0.0	4326	BREAST	-	-	-	-	CACNA1H	uc002ckt.3,p.D1673E|ENST00000565831,p.D1673E|uc002cks.3,p.D1679E|uc002ckv.3,p.D379E|ENST00000348261,p.D1679E|uc010brj.3,p.D390E|NM_001005407,p.D1673E|NM_021098,p.D1679E|uc002cku.3,p.D385E|ENST00000358590,p.D1673E	retained_intron, protein_coding	uc010brj.3	nonsynonymous SNV	exon10	c.C1170G	p.D390E	KLVAFGFRRFFKDRWNQLDLAIVLL	KLVAFGFRRFFKERWNQLDLAIVLL	5.0	6.0	-	-	4326_16:1265079-1265079 C>G_KLVAFGFRRFFKERWNQLDLAIVLL	0.0
2:108489139-108489139 T>G	0.0	4238	COLORECTAL	-	-	-	-	RGPD4	ENST00000408999,p.F1560C|ENST00000354986,p.F1560C|uc002tdu.3,p.F747C|NM_182588,p.F1560C|uc010ywk.2,p.F1560C	protein_coding	uc010ywk.2	nonsynonymous SNV	exon20	c.T4679G	p.F1560C	RIFSSEKSKPFAFGNSSATGSLFGF	RIFSSEKSKPFACGNSSATGSLFGF	2.0	4.0	-	-	4238_2:108489139-108489139 T>G_RIFSSEKSKPFACGNSSATGSLFGF	0.0
6:73830278-73830278 T>G	0.0	4213	COLORECTAL	-	-	-	-	KCNQ5	uc003pgj.4,p.L400V|ENST00000414165,p.L400V|ENST00000342056,p.L400V|uc011dyj.2,p.L400V|ENST00000370398,p.L400V|ENST00000355194,p.L400V|ENST00000370392,p.L400V|uc003pgk.3,p.L400V|NM_019842,p.L400V|NM_001160134,p.L400V|NM_001160133,p.L400V|uc011dyh.2,p.L400V	protein_coding	uc011dyj.2	nonsynonymous SNV	exon8	c.T1198G	p.L400V	VSIATWKPHLKALHTCSPTKKEQGE	VSIATWKPHLKAVHTCSPTKKEQGE	4.0	4.0	-	-	4213_6:73830278-73830278 T>G_VSIATWKPHLKAVHTCSPTKKEQGE	0.0
2:1271281-1271281 G>A	0.0	3795	MELANOMA	0.0009	-	ID=COSM1399184;OCCURENCE=1(large_intestine)	-	SNTG2	uc010ewi.3,p.E281K|ENST00000308624,p.E408K|ENST00000407292,p.E281K|NM_018968,p.E408K|uc002qwq.3,p.E408K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ewi.3	nonsynonymous SNV	exon8	c.G841A	p.E281K	GKSHVFNVELGSELAMWEKSFQRAT	GKSHVFNVELGSKLAMWEKSFQRAT	1.0	3.0	-	-	3795_2:1271281-1271281 G>A_GKSHVFNVELGSKLAMWEKSFQRAT	0.0
17:47656157-47656157 G>A	0.0	3903	MELANOMA	-	-	ID=COSM2698369;OCCURENCE=1(large_intestine)	-	NXPH3	NM_007225,p.R85H|uc002ipa.3,p.R85H|ENST00000513748,p.R85H|ENST00000328741,p.R85H	retained_intron, protein_coding	uc002ipa.3	nonsynonymous SNV	exon2	c.G254A	p.R85H	GEAWGILGQPPNRPNHSPPPSAKVK	GEAWGILGQPPNHPNHSPPPSAKVK	3.0	5.0	-	-	3903_17:47656157-47656157 G>A_GEAWGILGQPPNHPNHSPPPSAKVK	0.0
8:4277522-4277522 G>A	0.0	4259	COLORECTAL	-	-	ID=COSM3413033,COSM3413032;OCCURENCE=1(central_nervous_system)	-	CSMD1	ENST00000537824,p.T123M|NM_033225,p.T123M|ENST00000542608,p.T123M|uc022aqr.1,p.T123M|ENST00000602723,p.T123M|ENST00000539096,p.T123M|ENST00000602557,p.T123M|ENST00000520002,p.T123M|ENST00000400186,p.T123M	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon3	c.C368T	p.T123M	IVSTGSILTLWFTTDFAVSAQGFKA	IVSTGSILTLWFMTDFAVSAQGFKA	3.0	10.0	-	-	4259_8:4277522-4277522 G>A_IVSTGSILTLWFMTDFAVSAQGFKA	0.0
7:57528861-57528862 AA>-	0.0	4284	COLORECTAL	-	-	-	-	ZNF716	ENST00000420713,p.K232fs|uc011kdi.1,p.K232fs|NM_001159279,p.K232fs	protein_coding	uc011kdi.1	frameshift deletion	exon4	c.694_695del	p.K232fs	KSFNCSSTLTRHKRIHTGEKPYRCE	KSFNCSSTLTRHKNSYWRETLQM	4.0	8.0	-	-	4284_7:57528861-57528862 AA>-_KSFNCSSTLTRHKNSYWRETLQM	0.0
7:82545765-82545765 C>T	1.0	3678	MELANOMA	-	-	ID=COSM1092190,COSM1092189;OCCURENCE=1(endometrium)	-	PCLO	ENST00000423517,p.R3846Q|uc003uhv.2,p.R3846Q|uc010lec.3,p.R811Q|ENST00000333891,p.R3846Q|ENST00000437081,p.R566Q|NM_033026,p.R3846Q|uc003uhx.2,p.R3846Q|NM_014510,p.R3846Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc010lec.3	nonsynonymous SNV	exon2	c.G2432A	p.R811Q	MSDSEVSSTRPTRIESQHGIERPRT	MSDSEVSSTRPTQIESQHGIERPRT	7.0	9.0	-	-	3678_7:82545765-82545765 C>T_MSDSEVSSTRPTQIESQHGIERPRT	0.0
19:9452908-9452908 A>G	1.0	4213	COLORECTAL	-	-	-	-	ZNF559	NM_001202406,p.R325G|ENST00000538743,p.R181G|ENST00000603380,p.R261G|uc010xkn.2,p.R253G|NM_032497,p.R261G|uc031rjh.1,p.R30G|ENST00000605750,p.R247G|uc021uok.1,p.R261G|uc021uoj.1,p.R219G|NM_001202407,p.R219G|ENST00000393883,p.R261G|uc002mle.4,p.R325G|ENST00000587557,p.R325G|uc031rjg.1,p.R30G	protein_coding, processed_transcript	uc031rjh.1	nonsynonymous SNV	exon4	c.A88G	p.R30G	PFTESSYLTQHLRTHSRVLPIEHKK	PFTESSYLTQHLGTHSRVLPIEHKK	8.0	6.0	-	-	4213_19:9452908-9452908 A>G_PFTESSYLTQHLGTHSRVLPIEHKK	0.0
11:118984565-118984565 G>A	1.0	3919	MELANOMA	-	-	-	-	C2CD2L	ENST00000336702,p.G498E|NM_014807,p.G498E|uc001pvn.3,p.G498E	retained_intron, protein_coding, processed_transcript	uc001pvn.3	nonsynonymous SNV	exon12	c.G1493A	p.G498E	SGPSNTSHSSSPGDSHLSNGLDPVA	SGPSNTSHSSSPEDSHLSNGLDPVA	8.0	2.0	-	-	3919_11:118984565-118984565 G>A_SGPSNTSHSSSPEDSHLSNGLDPVA	0.0
1:174979171-174979171 G>A	1.0	4345	COLORECTAL	-	-	-	-	CACYBP	ENST00000367681,p.V172M|uc001gkj.1,p.V215M|NM_001007214,p.V172M|ENST00000367679,p.V215M|uc001gki.1,p.V172M|NM_014412,p.V215M|ENST00000405362,p.V172M	retained_intron, protein_coding	uc001gkj.1	nonsynonymous SNV	exon6	c.G643A	p.V215M	DDDMKRTINKAWVESREKQAKGDTE	DDDMKRTINKAWMESREKQAKGDTE	10.0	8.0	-	-	4345_1:174979171-174979171 G>A_DDDMKRTINKAWMESREKQAKGDTE	0.0
12:101731902-101731902 C>T	1.0	3713	MELANOMA	-	-	-	-	UTP20	NM_014503,p.L1239F|uc001tia.1,p.L1239F|ENST00000261637,p.L1239F	retained_intron, protein_coding	uc001tia.1	nonsynonymous SNV	exon30	c.C3715T	p.L1239F	PECDILTNVFAILSAKNLSDATASI	PECDILTNVFAIFSAKNLSDATASI	3.0	5.0	-	-	3713_12:101731902-101731902 C>T_PECDILTNVFAIFSAKNLSDATASI	0.0
16:67183409-67183409 C>T	0.0	4281	COLORECTAL	-	-	-	-	B3GNT9	uc021tka.1,p.R327Q|NM_033309,p.R327Q|uc002erf.3,p.R327Q|ENST00000449549,p.R327Q	protein_coding	uc021tka.1	nonsynonymous SNV	exon1	c.G980A	p.R327Q	DDVFLGMCLQRLRLTPEPHPAFRTF	DDVFLGMCLQRLQLTPEPHPAFRTF	4.0	8.0	-	-	4281_16:67183409-67183409 C>T_DDVFLGMCLQRLQLTPEPHPAFRTF	0.0
12:108912903-108912903 C>T	1.0	3879	MELANOMA	-	-	-	-	FICD	ENST00000552695,p.A343V|uc001tmx.1,p.A343V|NM_007076,p.A343V	protein_coding, processed_transcript	uc001tmx.1	nonsynonymous SNV	exon3	c.C1028T	p.A343V	MQEFVQWLNSEEAMNLHPVEFAALA	MQEFVQWLNSEEVMNLHPVEFAALA	4.0	4.0	-	-	3879_12:108912903-108912903 C>T_MQEFVQWLNSEEVMNLHPVEFAALA	0.0
2:236957705-236957705 C>T	1.0	3903	MELANOMA	-	-	-	-	AGAP1	ENST00000336665,p.P579S|NM_014914,p.P579S|NM_001037131,p.P632S|ENST00000409538,p.P844S|ENST00000304032,p.P632S|ENST00000428334,p.P471S|uc002vvt.3,p.P579S|uc002vvs.3,p.P632S	retained_intron, protein_coding	uc002vvt.3	nonsynonymous SNV	exon15	c.C1735T	p.P579S	GNSHCVDCETQNPNWASLNLGALMC	GNSHCVDCETQNSNWASLNLGALMC	7.0	4.0	-	-	3903_2:236957705-236957705 C>T_GNSHCVDCETQNSNWASLNLGALMC	0.0
19:37440656-37440656 G>C	1.0	4326	BREAST	0.0005	-	-	-	ZNF568	uc002ofd.3,p.E137Q|NM_198539,p.E201Q|uc002ofc.3,p.E201Q|uc010efe.3,p.E137Q|ENST00000587857,p.E137Q|ENST00000415168,p.E137Q|NM_001204835,p.E200Q|NM_001204836,p.E137Q|ENST00000333987,p.E201Q|NM_001204837,p.E137Q|uc021uts.1,p.E200Q	retained_intron, protein_coding	uc021uts.1	nonsynonymous SNV	exon7	c.G598C	p.E200Q	LDLLRYEKGCVREKQSNEFGKPFYH	LDLLRYEKGCVRQKQSNEFGKPFYH	7.0	6.0	-	-	4326_19:37440656-37440656 G>C_LDLLRYEKGCVRQKQSNEFGKPFYH	0.0
19:59028217-59028217 C>A	1.0	3879	MELANOMA	-	-	-	-	ZBTB45	ENST00000354590,p.G275V|ENST00000594051,p.G275V|NM_032792,p.G275V|uc002qtd.3,p.G275V|ENST00000600990,p.G275V|uc002qtf.3,p.G275V	protein_coding	uc002qtf.3	nonsynonymous SNV	exon2	c.G824T	p.G275V	ADYSGAGRDFLRGAGSAEDVFPDSY	ADYSGAGRDFLRVAGSAEDVFPDSY	4.0	8.0	-	-	3879_19:59028217-59028217 C>A_ADYSGAGRDFLRVAGSAEDVFPDSY	0.0
12:88589322-88589322 G>C	1.0	4284	COLORECTAL	-	-	-	-	TMTC3	NM_181783,p.E881Q|uc001tau.3,p.E881Q|ENST00000266712,p.E881Q	protein_coding, nonsense_mediated_decay	uc001tau.3	nonsynonymous SNV	exon14	c.G2641C	p.E881Q	KSNKQLGKNGDEETPHKTTKDIKEI	KSNKQLGKNGDEQTPHKTTKDIKEI	7.0	5.0	-	-	4284_12:88589322-88589322 G>C_KSNKQLGKNGDEQTPHKTTKDIKEI	0.0
1:31898664-31898664 C>G	1.0	3879	MELANOMA	-	-	-	-	SERINC2	uc009vtw.1,p.P145R	protein_coding, processed_transcript	uc009vtw.1	nonsynonymous SNV	exon4	c.C434G	p.P145R	VLLRRRGLLPLHPHPAGAAHRLCAL	VLLRRRGLLPLHRHPAGAAHRLCAL	6.0	6.0	-	-	3879_1:31898664-31898664 C>G_VLLRRRGLLPLHRHPAGAAHRLCAL	0.0
1:64644503-64644503 G>A	1.0	3713	MELANOMA	-	-	-	-	ROR1	ENST00000371079,p.G927R|ENST00000545203,p.G378R|uc001dbj.3,p.G927R|NM_005012,p.G927R	protein_coding, processed_transcript	uc001dbj.3	nonsynonymous SNV	exon9	c.G2779A	p.G927R	KQASLLGDANIHGHTESMISAEL	KQASLLGDANIHRHTESMISAEL	4.0	1.0	-	-	3713_1:64644503-64644503 G>A_KQASLLGDANIHRHTESMISAEL	0.0
5:71491204-71491204 A>C	1.0	4281	COLORECTAL	-	-	-	-	MAP1B	ENST00000504492,p.K548N|uc003kbw.4,p.K674N|ENST00000296755,p.K674N|uc010iyy.1,p.K548N|uc010iyx.1,p.K548N|uc010iyw.1,p.K691N|NM_005909,p.K674N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010iyy.1	nonsynonymous SNV	exon4	c.A1644C	p.K548N	KKEDKTPIKKEEKPKKEEVKKEVKK	KKEDKTPIKKEENPKKEEVKKEVKK	9.0	5.0	-	-	4281_5:71491204-71491204 A>C_KKEDKTPIKKEENPKKEEVKKEVKK	0.0
17:37587375-37587375 C>G	0.0	4186	BREAST	-	-	-	-	MED1	uc010wee.2,p.R42S|ENST00000300651,p.R214S|ENST00000394287,p.R214S|uc002hrv.4,p.R214S|NM_004774,p.R214S|uc002hru.2,p.R214S	retained_intron, protein_coding, nonsense_mediated_decay	uc010wee.2	nonsynonymous SNV	exon8	c.G126C	p.R42S	KILHGSVGYLTPRSGGHLMNLKYYV	KILHGSVGYLTPSSGGHLMNLKYYV	6.0	8.0	-	-	4186_17:37587375-37587375 C>G_KILHGSVGYLTPSSGGHLMNLKYYV	0.0
2:128753998-128753998 C>A	1.0	3678	MELANOMA	-	-	-	-	SAP130	uc002tpn.2,p.R214S|ENST00000259235,p.R453S|NM_024545,p.R453S|NM_001145928,p.R453S|ENST00000357702,p.R453S|uc002tpp.2,p.R453S|uc002tpq.1,p.R426S|uc010fmd.2,p.R453S|ENST00000259234,p.R427S	protein_coding	uc010fmd.2	nonsynonymous SNV	exon11	c.G1359T	p.R453S	TSPRIQPDYPAERSSLIPISGHRAS	TSPRIQPDYPAESSSLIPISGHRAS	6.0	10.0	-	-	3678_2:128753998-128753998 C>A_TSPRIQPDYPAESSSLIPISGHRAS	0.0
11:117093932-117093932 G>A	1.0	4155	MELANOMA	-	-	-	-	PCSK7	NM_004716,p.R383W|ENST00000540028,p.R24W|uc001pqr.3,p.R383W|ENST00000320934,p.R383W	retained_intron, protein_coding, processed_transcript	uc001pqr.3	nonsynonymous SNV	exon9	c.C1147T	p.R383W	LAVTFSGGDKMLRSIVTTDWDLQKG	LAVTFSGGDKMLWSIVTTDWDLQKG	9.0	6.0	-	-	4155_11:117093932-117093932 G>A_LAVTFSGGDKMLWSIVTTDWDLQKG	0.0
11:61188969-61188969 G>A	1.0	4245	COLORECTAL	-	-	-	-	CPSF7	uc009ynp.2,p.R56C|NM_024811,p.R99C|ENST00000448745,p.R56C|ENST00000340437,p.R99C|ENST00000544585,p.R56C|uc001nrr.3,p.R56C|ENST00000539952,p.R56C|uc001nrp.3,p.R99C|ENST00000541963,p.R56C|ENST00000536145,p.R56C|ENST00000439958,p.R56C|ENST00000477890,p.R56C|ENST00000450000,p.R56C|ENST00000449811,p.R56C|ENST00000536548,p.R56C|ENST00000537162,p.R56C|NM_001142565,p.R56C|ENST00000543545,p.R56C|ENST00000535222,p.R56C|ENST00000544990,p.R56C|uc001nrq.3,p.R56C|ENST00000413184,p.R56C|ENST00000394888,p.R56C|NM_001136040,p.R56C|ENST00000413232,p.R56C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009ynp.2	nonsynonymous SNV	exon3	c.C166T	p.R56C	DRSSSTEPPPPVRQEPSPKPNNKTP	DRSSSTEPPPPVCQEPSPKPNNKTP	8.0	9.0	-	-	4245_11:61188969-61188969 G>A_DRSSSTEPPPPVCQEPSPKPNNKTP	0.0
8:101076199-101076199 G>C	0.0	3775	CERVICAL	-	-	-	-	RGS22	ENST00000523287,p.S85C|NM_001286693,p.S85C|uc003yjc.1,p.S254C|ENST00000523437,p.S254C|uc003yjb.1,p.S266C|ENST00000360863,p.S266C|NM_001286692,p.S254C|uc003yja.1,p.S85C|NM_015668,p.S266C|ENST00000519725,p.S266C|uc022azh.1,p.S170C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022azh.1	nonsynonymous SNV	exon5	c.C509G	p.S170C	TKKDPSKTNKLISEFEEEEGEEEEV	TKKDPSKTNKLICEFEEEEGEEEEV	3.0	9.0	-	-	3775_8:101076199-101076199 G>C_TKKDPSKTNKLICEFEEEEGEEEEV	0.0
X:67938254-67938254 G>A	1.0	3713	MELANOMA	-	-	-	-	STARD8	ENST00000252336,p.E420K|uc004dxc.4,p.E420K|uc004dxa.3,p.E420K|NM_001142503,p.E500K|uc004dxb.3,p.E500K|NM_001142504,p.E420K|NM_014725,p.E420K|ENST00000374599,p.E500K|ENST00000374597,p.E420K	protein_coding, processed_transcript, nonsense_mediated_decay	uc004dxc.4	nonsynonymous SNV	exon5	c.G1258A	p.E420K	APAPAPAQDSEQEAHSGGEPTFASS	APAPAPAQDSEQKAHSGGEPTFASS	3.0	8.0	-	-	3713_X:67938254-67938254 G>A_APAPAPAQDSEQKAHSGGEPTFASS	0.0
11:103870929-103870929 C>T	1.0	2591	MELANOMA	-	-	-	-	PDGFD	ENST00000302251,p.G54E|NM_033135,p.G54E|uc001php.3,p.G54E|uc001phq.3,p.G60E|NM_025208,p.G60E|ENST00000529268,p.G83E|ENST00000393158,p.G60E	protein_coding	uc001phq.3	nonsynonymous SNV	exon2	c.G179A	p.G60E	DLYRRDETIQVKGNGYVQSPRFPNS	DLYRRDETIQVKENGYVQSPRFPNS	6.0	5.0	-	-	2591_11:103870929-103870929 C>T_DLYRRDETIQVKENGYVQSPRFPNS	0.0
5:127638775-127638775 T>A	0.0	4284	COLORECTAL	-	-	-	-	FBN2	ENST00000508053,p.D1936V|NM_001999,p.D1936V|ENST00000262464,p.D1936V|uc003kuu.3,p.D1936V	retained_intron, protein_coding, processed_transcript	uc003kuu.3	nonsynonymous SNV	exon46	c.A5807T	p.D1936V	KASQDQTMCMDVDECERHPCGNGTC	KASQDQTMCMDVVECERHPCGNGTC	4.0	1.0	-	-	4284_5:127638775-127638775 T>A_KASQDQTMCMDVVECERHPCGNGTC	0.0
11:72466165-72466165 G>A	1.0	4317	COLORECTAL	-	-	-	-	STARD10	uc001otb.3,p.A218V|uc001ota.3,p.A172V|NM_006645,p.A218V|uc001osz.4,p.A218V|uc001osy.3,p.A218V	-	uc001otb.3	nonsynonymous SNV	exon7	c.C653T	p.A218V	FLAPKAMKKMYKACLKYPEWKQKHL	FLAPKAMKKMYKVCLKYPEWKQKHL	10.0	2.0	-	-	4317_11:72466165-72466165 G>A_FLAPKAMKKMYKVCLKYPEWKQKHL	0.0
10:14816509-14816509 C>T	0.0	4320	COLORECTAL	-	-	-	-	FAM107B	uc001ina.1,p.V52I|ENST00000181796,p.V52I|ENST00000487335,p.V52I|NM_031453,p.V52I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ina.1	nonsynonymous SNV	exon1	c.G154A	p.V52I	FNQSGVADTHSTVRVQPVAKAGRQP	FNQSGVADTHSTIRVQPVAKAGRQP	8.0	7.0	-	-	4320_10:14816509-14816509 C>T_FNQSGVADTHSTIRVQPVAKAGRQP	0.0
8:144789949-144789949 C>T	0.0	3466	MELANOMA	-	-	-	-	CCDC166	NM_001162914,p.E111K|ENST00000542437,p.E111K|uc011lkr.2,p.E111K	protein_coding	uc011lkr.2	nonsynonymous SNV	exon1	c.G331A	p.E111K	RVDLAQIHWQRAELASLYHGREDGV	RVDLAQIHWQRAKLASLYHGREDGV	1.0	8.0	-	-	3466_8:144789949-144789949 C>T_RVDLAQIHWQRAKLASLYHGREDGV	0.0
8:71068822-71068822 G>A	1.0	3784	MELANOMA	-	-	-	1	NCOA2	ENST00000518287,p.S593F|ENST00000452400,p.S593F|NM_006540,p.S593F|uc003xyn.1,p.S593F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xyn.1	nonsynonymous SNV	exon11	c.C1778T	p.S593F	DSKDCFGLYGEPSEGTTGQAESSCH	DSKDCFGLYGEPFEGTTGQAESSCH	9.0	4.0	-	-	3784_8:71068822-71068822 G>A_DSKDCFGLYGEPFEGTTGQAESSCH	0.0
X:107838784-107838784 C>T	1.0	3713	MELANOMA	-	-	-	-	COL4A5	NM_000495,p.S490L|uc004eob.1,p.S98L|uc004enz.2,p.S490L|uc022ccg.2,p.S490L|ENST00000361603,p.S490L|ENST00000328300,p.S490L	retained_intron, protein_coding, processed_transcript	uc022ccg.2	nonsynonymous SNV	exon22	c.C1469T	p.S490L	GDTCFNCIGTGISGPPGQPGLPGLP	GDTCFNCIGTGILGPPGQPGLPGLP	2.0	10.0	-	-	3713_X:107838784-107838784 C>T_GDTCFNCIGTGILGPPGQPGLPGLP	0.0
7:138968617-138968617 C>T	1.0	3713	MELANOMA	-	-	-	-	UBN2	uc011kqr.2,p.P989L|NM_173569,p.P989L|ENST00000288561,p.P906L|ENST00000473989,p.P989L	protein_coding	uc011kqr.2	nonsynonymous SNV	exon15	c.C2966T	p.P989L	PLMYRLPLSTPSPGNGSQGSHPLVS	PLMYRLPLSTPSLGNGSQGSHPLVS	7.0	3.0	-	-	3713_7:138968617-138968617 C>T_PLMYRLPLSTPSLGNGSQGSHPLVS	0.0
4:73414382-73414382 G>A	0.0	4329	COLORECTAL	-	-	-	-	ADAMTS3	uc003hgk.2,p.A106V|NM_014243,p.A106V|ENST00000286657,p.A106V	protein_coding, processed_transcript	uc003hgk.2	nonsynonymous SNV	exon3	c.C317T	p.A106V	RLKPNTQLVAPGAVVEWHETSLVPG	RLKPNTQLVAPGVVVEWHETSLVPG	3.0	4.0	-	-	4329_4:73414382-73414382 G>A_RLKPNTQLVAPGVVVEWHETSLVPG	0.0
17:7577120-7577120 C>T	1.0	4160	COLORECTAL	0.0005	-	ID=COSM99729,COSM1645335,COSM3356963,COSM10660;OCCURENCE=1(vulva),32(oesophagus),44(upper_aerodigestive_tract),4(bone),1(thymus),45(central_nervous_system),22(stomach),1(cervix),27(haematopoietic_and_lymphoid_tissue),42(lung),4(penis),8(endometrium),57(ovary),1(soft_tissue),1(fallopian_tube),5(biliary_tract),144(large_intestine),19(urinary_tract),2(genital_tract),4(liver),25(pancreas),70(breast),8(skin)	1	TP53	uc002gij.3,p.R234H|NM_001276761,p.R234H|NM_001126118,p.R234H|NM_000546,p.R273H|ENST00000455263,p.R273H|uc002gii.2,p.R114H|NM_001276698,p.R114H|ENST00000509690,p.R141H|NM_001276697,p.R114H|NM_001276695,p.R234H|NM_001126115,p.R141H|ENST00000445888,p.R273H|NM_001126116,p.R141H|ENST00000420246,p.R273H|ENST00000359597,p.R273H|NM_001126117,p.R141H|NM_001276696,p.R234H|uc002gih.3,p.R273H|NM_001126114,p.R273H|uc010cng.2,p.R114H|NM_001276699,p.R114H|ENST00000269305,p.R273H|NM_001126112,p.R273H|NM_001126113,p.R273H|NM_001276760,p.R234H|uc031qyq.1,p.R234H|uc010cnf.2,p.R114H	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon7	c.G701A	p.R234H	SGNLLGRNSFEVRVCACPGRDRRTE	SGNLLGRNSFEVHVCACPGRDRRTE	10.0	10.0	-	-	4160_17:7577120-7577120 C>T_SGNLLGRNSFEVHVCACPGRDRRTE	0.0
17:74011655-74011655 C>T	0.0	3998	MELANOMA	-	-	-	-	EVPL	uc010wss.1,p.E611K|ENST00000301607,p.E589K|uc010wst.1,p.E59K|ENST00000586740,p.E611K|NM_001988,p.E589K|uc002jqi.2,p.E589K	retained_intron, protein_coding	uc010wst.1	nonsynonymous SNV	exon13	c.G175A	p.E59K	QSLGTEKETAQKECEAFLSTRPVGP	QSLGTEKETAQKKCEAFLSTRPVGP	1.0	8.0	-	-	3998_17:74011655-74011655 C>T_QSLGTEKETAQKKCEAFLSTRPVGP	0.0
12:58109709-58109709 C>T	1.0	4000	MELANOMA	-	-	-	-	OS9	ENST00000389142,p.S249F|NM_001261420,p.S249F|ENST00000439210,p.S190F|uc001spj.3,p.S249F|uc001spm.3,p.S249F|uc001spn.3,p.S249F|ENST00000257966,p.S249F|uc031qia.1,p.S197F|NM_001261423,p.S190F|ENST00000315970,p.S249F|NM_001261422,p.S197F|ENST00000552285,p.S249F|uc001spk.3,p.S249F|NM_001017958,p.S249F|uc010sry.2,p.S216F|NM_001261421,p.S216F|ENST00000551035,p.S216F|uc010srz.2,p.S190F|uc001spl.3,p.S249F|NM_001017957,p.S249F|ENST00000389146,p.S249F|NM_006812,p.S249F|NM_001017956,p.S249F|ENST00000435406,p.S197F	retained_intron, protein_coding, nonsense_mediated_decay	uc031qia.1	nonsynonymous SNV	exon5	c.C590T	p.S197F	PSAAPQAILCHPSLQPEEYMAYVQR	PSAAPQAILCHPFLQPEEYMAYVQR	10.0	6.0	-	-	4000_12:58109709-58109709 C>T_PSAAPQAILCHPFLQPEEYMAYVQR	0.0
8:3063133-3063133 C>A	0.0	4284	COLORECTAL	-	-	-	-	CSMD1	ENST00000537824,p.G1626V|NM_033225,p.G1626V|uc022aqr.1,p.G1626V|ENST00000539096,p.G1626V|ENST00000520002,p.G1627V|ENST00000542608,p.G1626V|ENST00000602723,p.G1627V|uc003wqe.3,p.G783V|uc011kwj.2,p.G1019V|ENST00000400186,p.G1627V|ENST00000602557,p.G1627V	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon31	c.G4877T	p.G1626V	WDQVLPSCNAPCGGQYTGSEGVVLS	WDQVLPSCNAPCVGQYTGSEGVVLS	2.0	2.0	-	-	4284_8:3063133-3063133 C>A_WDQVLPSCNAPCVGQYTGSEGVVLS	0.0
14:97009182-97009182 C>A	1.0	4158	COLORECTAL	-	-	-	-	PAPOLA	NM_001293628,p.A164D|NM_001293632,p.A164D|NM_032632,p.A414D|ENST00000216277,p.A414D|NM_001293627,p.A414D|uc001yfq.3,p.A414D|uc010twv.2,p.A414D|uc010avp.3,p.A164D|uc001yfr.3,p.A414D|ENST00000392990,p.A414D|ENST00000555626,p.A164D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010twv.2	nonsynonymous SNV	exon14	c.C1241A	p.A414D	VGSLEKNEFITLAHVNPQSFPAPKE	VGSLEKNEFITLDHVNPQSFPAPKE	9.0	6.0	-	-	4158_14:97009182-97009182 C>A_VGSLEKNEFITLDHVNPQSFPAPKE	0.0
3:195615440-195615440 G>A	1.0	4284	COLORECTAL	-	-	-	-	TNK2	uc003fvt.1,p.T70I|ENST00000428187,p.T39I|uc010hzx.1,p.T21I|ENST00000381916,p.T70I|uc003fvs.1,p.T39I|NM_001010938,p.T70I|ENST00000427576,p.T71I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010hzx.1	nonsynonymous SNV	exon2	c.C62T	p.T21I	RLGGGRMQPEEGTGWLLELLSEVQL	RLGGGRMQPEEGIGWLLELLSEVQL	8.0	10.0	-	-	4284_3:195615440-195615440 G>A_RLGGGRMQPEEGIGWLLELLSEVQL	0.0
20:42635214-42635214 G>A	0.0	3713	MELANOMA	0.0005	-	-	-	TOX2	ENST00000372999,p.E23K|NM_001098797,p.E65K|NM_001098798,p.E74K|uc002xlf.4,p.E74K|ENST00000341197,p.E65K|ENST00000358131,p.E74K|uc010ggp.3,p.E23K|uc010ggo.3,p.E65K|ENST00000442881,p.E23K|uc002xle.4,p.E23K|uc021wdz.2,p.E65K|ENST00000423191,p.E23K|NM_032883,p.E23K|NM_001098796,p.E23K	protein_coding	uc021wdz.2	nonsynonymous SNV	exon3	c.G193A	p.E65K	TSQTYNGQSENNEDYEIPPITPPNL	TSQTYNGQSENNKDYEIPPITPPNL	4.0	2.0	-	-	3713_20:42635214-42635214 G>A_TSQTYNGQSENNKDYEIPPITPPNL	0.0
5:140516577-140516577 G>A	0.0	4235	COLORECTAL	-	-	ID=COSM3610651;OCCURENCE=1(lung)	-	PCDHB5	ENST00000231134,p.E521K|NM_015669,p.E521K|uc003liq.3,p.E521K	protein_coding	uc003liq.3	nonsynonymous SNV	exon1	c.G1561A	p.E521K	NGHLFALRSLDYEALQAFEFRVGAT	NGHLFALRSLDYKALQAFEFRVGAT	5.0	6.0	-	-	4235_5:140516577-140516577 G>A_NGHLFALRSLDYKALQAFEFRVGAT	0.0
20:62321161-62321161 T>C	1.0	4196	COLORECTAL	-	-	-	-	RTEL1	ENST00000360203,p.I695T|NM_032957,p.I719T|ENST00000482936,p.I695T|NM_016434,p.I695T|uc011abd.2,p.I719T|ENST00000508582,p.I719T|ENST00000425905,p.I88T|ENST00000492259,p.I723T|uc002yfu.2,p.I695T|NM_001283010,p.I472T|uc011abe.1,p.I472T|NM_001283009,p.I695T|ENST00000318100,p.I695T|ENST00000370018,p.I695T	protein_coding, processed_transcript, nonsense_mediated_decay	uc011abe.1	nonsynonymous SNV	exon23	c.T1415C	p.I472T	YRQQASRAVNQAIGRVIRHRQDYGA	YRQQASRAVNQATGRVIRHRQDYGA	9.0	7.0	-	-	4196_20:62321161-62321161 T>C_YRQQASRAVNQATGRVIRHRQDYGA	0.0
6:100369042-100369042 G>A	0.0	2591	MELANOMA	-	-	-	-	MCHR2	uc003pqh.1,p.P266L|NM_001040179,p.P266L|NM_032503,p.P266L|uc003pqi.1,p.P266L|ENST00000445970,p.P266L|ENST00000281806,p.P266L|ENST00000369212,p.P266L	protein_coding	uc003pqi.1	nonsynonymous SNV	exon6	c.C797T	p.P266L	LVLVVVFILSAAPYHVIQLVNLQME	LVLVVVFILSAALYHVIQLVNLQME	1.0	7.0	-	-	2591_6:100369042-100369042 G>A_LVLVVVFILSAALYHVIQLVNLQME	0.0
4:157771520-157771520 C>T	1.0	4177	PANCREATIC	-	-	-	-	PDGFC	NM_016205,p.G56E|uc003iph.2,p.G56E|ENST00000422544,p.G56E|ENST00000502773,p.G56E	protein_coding, processed_transcript, nonsense_mediated_decay	uc003iph.2	nonsynonymous SNV	exon2	c.G167A	p.G56E	PQHERIITVSTNGSIHSPRFPHTYP	PQHERIITVSTNESIHSPRFPHTYP	9.0	6.0	-	-	4177_4:157771520-157771520 C>T_PQHERIITVSTNESIHSPRFPHTYP	0.0
17:73265484-73265484 C>A	1.0	4287	COLORECTAL	-	-	ID=COSM984335;OCCURENCE=1(endometrium)	-	MIF4GD	uc002jnp.3,p.R43M|NM_001242500,p.R43M|ENST00000577542,p.R50M|uc002jnq.3,p.R50M|ENST00000245551,p.R43M|ENST00000579612,p.R43M|ENST00000579297,p.R50M|ENST00000579194,p.R50M|NM_001242498,p.R50M|NM_020679,p.R43M	retained_intron, protein_coding	uc002jnq.3	nonsynonymous SNV	exon3	c.G149T	p.R50M	FETEDGEYSVCQRSYSNCSRLMPSR	FETEDGEYSVCQMSYSNCSRLMPSR	8.0	8.0	-	-	4287_17:73265484-73265484 C>A_FETEDGEYSVCQMSYSNCSRLMPSR	0.0
X:49845342-49845342 C>T	0.0	4298	COLORECTAL	-	-	-	-	CLCN5	NM_000084,p.A162V|uc004doq.1,p.A232V|NM_001282163,p.A182V|uc004dot.1,p.A162V|ENST00000376108,p.A162V|uc031tjo.1,p.A182V|ENST00000307367,p.A162V|ENST00000376088,p.A232V|ENST00000376091,p.A232V|uc004dor.1,p.A232V|uc004dos.1,p.A162V|NM_001127898,p.A232V|NM_001127899,p.A232V	protein_coding, processed_transcript	uc031tjo.1	nonsynonymous SNV	exon5	c.C545T	p.A182V	FAFLAVSLVKVFAPYACGSGIPEIK	FAFLAVSLVKVFVPYACGSGIPEIK	5.0	8.0	-	-	4298_X:49845342-49845342 C>T_FAFLAVSLVKVFVPYACGSGIPEIK	0.0
9:4118775-4118775 G>A	1.0	3713	MELANOMA	-	-	-	-	GLIS3	uc010mhi.1,p.P42S|uc003zif.1,p.P13S|uc003zie.1,p.P235S|uc003zig.1,p.P79S|uc003zib.1,p.P79S|uc003zhy.1,p.P13S|NM_152629,p.P80S|ENST00000324333,p.P80S|uc003zhz.1,p.P13S|uc003zid.1,p.P13S|ENST00000381971,p.P235S|uc010mhg.1,p.P13S|uc003zic.1,p.P235S|uc003zih.1,p.P13S|uc003zhw.1,p.P80S|uc003zhx.1,p.P235S|uc010mhh.1,p.P110S|NM_001042413,p.P235S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010mhi.1	nonsynonymous SNV	exon2	c.C124T	p.P42S	MKQEWSQGYRALPSLSNHGSQNGLD	MKQEWSQGYRALSSLSNHGSQNGLD	1.0	9.0	-	-	3713_9:4118775-4118775 G>A_MKQEWSQGYRALSSLSNHGSQNGLD	0.0
4:169227835-169227835 G>T	1.0	4095	COLORECTAL	-	-	-	-	DDX60	ENST00000514995,p.L101I|ENST00000393743,p.L101I|NM_017631,p.L101I|uc003irp.3,p.L101I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003irp.3	nonsynonymous SNV	exon5	c.C301A	p.L101I	DAEYAYFNFPELLSLRTALILHLQK	DAEYAYFNFPELISLRTALILHLQK	8.0	3.0	-	-	4095_4:169227835-169227835 G>T_DAEYAYFNFPELISLRTALILHLQK	0.0
19:12986985-12986985 G>T	1.0	4326	BREAST	-	-	-	-	DNASE2	uc010xmr.1,p.S246Y|NM_001375,p.S301Y|ENST00000222219,p.S301Y|ENST00000538460,p.S246Y|uc002mvn.1,p.S301Y	retained_intron, protein_coding	uc010xmr.1	nonsynonymous SNV	exon5	c.C737A	p.S246Y	FNSTEDHSKWCVSPKGPWTCVGDMN	FNSTEDHSKWCVYPKGPWTCVGDMN	9.0	7.0	-	-	4326_19:12986985-12986985 G>T_FNSTEDHSKWCVYPKGPWTCVGDMN	0.0
1:24175329-24175329 C>T	1.0	4326	BREAST	-	-	-	-	FUCA1	ENST00000374479,p.E324K|uc001bie.3,p.E324K|NM_000147,p.E324K	protein_coding	uc001bie.3	nonsynonymous SNV	exon6	c.G970A	p.E324K	LSDVTEESEIISELVQTVSLGGNYL	LSDVTEESEIISKLVQTVSLGGNYL	9.0	9.0	-	-	4326_1:24175329-24175329 C>T_LSDVTEESEIISKLVQTVSLGGNYL	0.0
17:62589659-62589659 C>T	1.0	3879	MELANOMA	-	-	-	-	SMURF2	NM_022739,p.S78N|ENST00000262435,p.S78N|uc002jep.1,p.S78N|ENST00000585301,p.S65N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002jep.1	nonsynonymous SNV	exon4	c.G233A	p.S78N	DLYIGKSDSVTISVWNHKKIHKKQG	DLYIGKSDSVTINVWNHKKIHKKQG	8.0	8.0	-	-	3879_17:62589659-62589659 C>T_DLYIGKSDSVTINVWNHKKIHKKQG	0.0
6:34802155-34802155 C>T	1.0	3716	MELANOMA	-	-	-	-	UHRF1BP1	ENST00000452449,p.T167I|NM_017754,p.T167I|uc003oju.4,p.T167I|ENST00000192788,p.T167I	protein_coding	uc003oju.4	nonsynonymous SNV	exon5	c.C500T	p.T167I	VNPNWQQSDLRLTRITDPCRGEVLT	VNPNWQQSDLRLIRITDPCRGEVLT	6.0	3.0	-	-	3716_6:34802155-34802155 C>T_VNPNWQQSDLRLIRITDPCRGEVLT	0.0
4:110606519-110606519 C>G	0.0	4266	COLORECTAL	-	-	-	-	CCDC109B	NM_017918,p.A310G|uc011cfs.2,p.A310G|ENST00000394650,p.A310G	retained_intron, protein_coding, processed_transcript	uc011cfs.2	nonsynonymous SNV	exon7	c.C929G	p.A310G	DVQQYNKLKEDLAKAKESLKQARHS	DVQQYNKLKEDLGKAKESLKQARHS	6.0	1.0	-	-	4266_4:110606519-110606519 C>G_DVQQYNKLKEDLGKAKESLKQARHS	0.0
16:29974909-29974909 A>T	1.0	4245	COLORECTAL	-	-	-	-	TMEM219	ENST00000414689,p.K118N|uc010bzk.1,p.K118N|uc002duy.2,p.K118N|ENST00000569445,p.K63N|ENST00000561899,p.K118N|NM_194280,p.K118N|ENST00000279396,p.K118N|ENST00000602948,p.K118N|ENST00000575829,p.K118N|NM_001083613,p.K118N|uc002duw.2,p.K118N|ENST00000566848,p.K118N	protein_coding, nonsense_mediated_decay	uc010bzk.1	nonsynonymous SNV	exon3	c.A354T	p.K118N	FQATVLGSQMGLKGSSAGQLVLITA	FQATVLGSQMGLNGSSAGQLVLITA	10.0	1.0	-	-	4245_16:29974909-29974909 A>T_FQATVLGSQMGLNGSSAGQLVLITA	0.0
7:140453136-140453136 A>T	1.0	3998	MELANOMA	-	-	ID=COSM476;OCCURENCE=3(adrenal_gland),3(urinary_tract),4(genital_tract),7(pancreas),16(liver),68(eye),2(prostate),4161(large_intestine),21(biliary_tract),11(breast),4377(skin),9(small_intestine),1(autonomic_ganglia),20(pituitary),242(ovary),32(soft_tissue),7(testis),459(haematopoietic_and_lymphoid_tissue),9534(thyroid),78(lung),1(meninges),12(upper_aerodigestive_tract),717(NS),15(bone),2(oesophagus),4(stomach),228(central_nervous_system)	1	BRAF	uc003vwc.4,p.V600E|ENST00000479537,p.V28E|ENST00000288602,p.V600E|NM_004333,p.V600E	retained_intron, protein_coding, nonsense_mediated_decay	uc003vwc.4	nonsynonymous SNV	exon15	c.T1799A	p.V600E	LTVKIGDFGLATVKSRWSGSHQFEQ	LTVKIGDFGLATEKSRWSGSHQFEQ	9.0	1.0	-	-	3998_7:140453136-140453136 A>T_LTVKIGDFGLATEKSRWSGSHQFEQ	0.0
2:204255788-204255788 A>C	1.0	4244	COLORECTAL	-	-	-	-	ABI2	NM_001282925,p.K167T|ENST00000417864,p.K167T|uc002vaa.3,p.K167T|ENST00000295851,p.K167T|ENST00000422511,p.K167T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002vaa.3	nonsynonymous SNV	exon5	c.A500C	p.K167T	WLLRFKVSTQNMKMGGLPRTTPPTQ	WLLRFKVSTQNMTMGGLPRTTPPTQ	8.0	2.0	-	-	4244_2:204255788-204255788 A>C_WLLRFKVSTQNMTMGGLPRTTPPTQ	0.0
1:157659596-157659596 C>T	0.0	4110	BILE DUCT	-	-	-	-	FCRL3	uc001fra.3,p.R327K|ENST00000477837,p.R506K|uc001frb.3,p.R601K|uc001frc.1,p.R601K|ENST00000492769,p.R607K|uc001fqz.4,p.R601K|ENST00000485028,p.R601K|ENST00000368186,p.R601K|NM_052939,p.R601K|ENST00000368184,p.R601K	protein_coding, processed_transcript, nonsense_mediated_decay	uc001frc.1	nonsynonymous SNV	exon10	c.G1802A	p.R601K	AAAALLHYARARRKPGGLSATGTSS	AAAALLHYARARKKPGGLSATGTSS	2.0	5.0	-	-	4110_1:157659596-157659596 C>T_AAAALLHYARARKKPGGLSATGTSS	0.0
15:78466831-78466831 G>A	0.0	4110	BILE DUCT	-	-	-	-	ACSBG1	NM_001199377,p.P576S|ENST00000258873,p.P580S|ENST00000541759,p.P338S|uc002bdh.3,p.P580S|ENST00000560817,p.P338S|uc010umx.2,p.P338S|NM_015162,p.P580S|uc010umw.2,p.P576S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010umx.2	nonsynonymous SNV	exon8	c.C1012T	p.P338S	ELIITAGGENVPPVPIEEAVKMELP	ELIITAGGENVPSVPIEEAVKMELP	2.0	10.0	-	-	4110_15:78466831-78466831 G>A_ELIITAGGENVPSVPIEEAVKMELP	0.0
10:25885710-25885710 G>A	1.0	3903	MELANOMA	-	-	-	-	GPR158	ENST00000376351,p.D713N|NM_020752,p.D713N|uc001isk.3,p.D88N|uc001isj.3,p.D713N	protein_coding, processed_transcript	uc001isk.3	nonsynonymous SNV	exon2	c.G262A	p.D88N	NSAWSEHSLDPEDIRDELKKLYAQL	NSAWSEHSLDPENIRDELKKLYAQL	5.0	9.0	-	-	3903_10:25885710-25885710 G>A_NSAWSEHSLDPENIRDELKKLYAQL	0.0
2:241494422-241494422 A>C	1.0	4316	COLORECTAL	-	-	-	-	ANKMY1	ENST00000403283,p.L145R|NM_017844,p.L66R|NM_001282771,p.L66R|NM_001282781,p.L66R|ENST00000361678,p.L66R|uc010fzd.1,p.L66R|ENST00000536462,p.L19R|uc002vzd.1,p.L66R|uc002vzc.1,p.L66R|ENST00000441168,p.L19R|ENST00000406958,p.L66R|uc002vzb.1,p.L66R|NM_001282780,p.L66R|ENST00000401804,p.L66R|ENST00000405523,p.L66R|ENST00000373318,p.L66R|uc002vza.1,p.L66R	retained_intron, protein_coding, processed_transcript	uc010fzd.1	nonsynonymous SNV	exon3	c.T197G	p.L66R	APEKEEEEAEGPLRAQDLRESYIQL	APEKEEEEAEGPRRAQDLRESYIQL	9.0	7.0	-	-	4316_2:241494422-241494422 A>C_APEKEEEEAEGPRRAQDLRESYIQL	0.0
9:104238518-104238518 C>T	0.0	4186	BREAST	-	-	-	-	TMEM246	ENST00000374848,p.R286H|ENST00000374851,p.R286H|uc004bbm.3,p.R286H|ENST00000374847,p.R286H|NM_032342,p.R286H|uc022blf.1,p.R286H	protein_coding, processed_transcript	uc022blf.1	nonsynonymous SNV	exon1	c.G857A	p.R286H	PLLTWIYMRFASRPGFSWPVMLFFS	PLLTWIYMRFASHPGFSWPVMLFFS	1.0	10.0	-	-	4186_9:104238518-104238518 C>T_PLLTWIYMRFASHPGFSWPVMLFFS	0.0
15:101432743-101432743 C>A	0.0	4346	COLORECTAL	-	-	-	-	ALDH1A3	ENST00000561338,p.P97Q|ENST00000329841,p.P125Q|uc002bwn.4,p.P125Q|NM_000693,p.P125Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002bwn.4	nonsynonymous SNV	exon4	c.C374A	p.P125Q	TLAALETMDTGKPFLHAFFIDLEGC	TLAALETMDTGKQFLHAFFIDLEGC	4.0	7.0	-	-	4346_15:101432743-101432743 C>A_TLAALETMDTGKQFLHAFFIDLEGC	0.0
5:140057599-140057599 T>A	1.0	4259	COLORECTAL	-	-	-	-	HARS	uc003lgv.4,p.D175V|NM_001289094,p.D146V|NM_001258040,p.D135V|uc011czm.3,p.D135V|ENST00000438307,p.D135V|NM_002109,p.D175V|ENST00000448240,p.D13V|ENST00000504366,p.D106V|ENST00000504156,p.D175V|uc003lgu.3,p.D106V	retained_intron, protein_coding, nonsense_mediated_decay	uc011czm.3	nonsynonymous SNV	exon5	c.A404T	p.D135V	MTRGRYREFYQCDFDIAGNFDPMIP	MTRGRYREFYQCVFDIAGNFDPMIP	10.0	6.0	-	-	4259_5:140057599-140057599 T>A_MTRGRYREFYQCVFDIAGNFDPMIP	0.0
15:49170780-49170780 T>C	1.0	4326	BREAST	-	-	-	-	EID1	uc001zxc.1,p.L136P|ENST00000530028,p.L136P|NM_014335,p.L136P|ENST00000560490,p.L114P	protein_coding, processed_transcript	uc001zxc.1	nonsynonymous SNV	exon1	c.T407C	p.L136P	VSAALEEADKMFLRTREPALDGGFQ	VSAALEEADKMFPRTREPALDGGFQ	9.0	9.0	-	-	4326_15:49170780-49170780 T>C_VSAALEEADKMFPRTREPALDGGFQ	0.0
5:39119072-39119072 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	FYB	uc003jlu.3,p.G723R|NM_001465,p.G769R|ENST00000512982,p.G769R|ENST00000515010,p.G723R|uc011cpl.2,p.G779R|NM_001243093,p.G779R|uc003jls.3,p.G723R|ENST00000351578,p.G723R|ENST00000505428,p.G769R|ENST00000540520,p.G779R|NM_199335,p.G723R|uc003jlt.3,p.G769R	protein_coding, processed_transcript	uc011cpl.2	nonsynonymous SNV	exon16	c.G2335A	p.G779R	TKVTTSITSKKWGTRDLQVKPGESL	TKVTTSITSKKWRTRDLQVKPGESL	7.0	6.0	-	-	4258_5:39119072-39119072 C>T_TKVTTSITSKKWRTRDLQVKPGESL	0.0
7:135262562-135262562 G>A	0.0	4345	COLORECTAL	-	-	-	-	NUP205	ENST00000285968,p.E223K|NM_015135,p.E223K|uc003vsw.3,p.E223K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vsw.3	nonsynonymous SNV	exon6	c.G667A	p.E223K	EKHRKEVSDLIKECRQSLAESLFAW	EKHRKEVSDLIKKCRQSLAESLFAW	8.0	6.0	-	-	4345_7:135262562-135262562 G>A_EKHRKEVSDLIKKCRQSLAESLFAW	0.0
11:83984264-83984264 T>C	0.0	4346	COLORECTAL	-	-	-	-	DLG2	uc010rsy.1,p.Y12C|ENST00000531015,p.Y12C|ENST00000529401,p.Y12C|NM_001142700,p.Y12C|ENST00000418306,p.Y12C|uc001pai.2,p.Y12C|uc010rtb.1,p.Y12C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rtb.1	nonsynonymous SNV	exon1	c.A35G	p.Y12C	MQRPSVSRAENYQLLWDTIASLKQ	MQRPSVSRAENCQLLWDTIASLKQ	3.0	9.0	-	-	4346_11:83984264-83984264 T>C_MQRPSVSRAENCQLLWDTIASLKQ	0.0
12:116446558-116446558 G>A	1.0	3466	MELANOMA	-	-	-	-	MED13L	uc001tvw.3,p.P554S|NM_015335,p.P554S|ENST00000281928,p.P554S	retained_intron, protein_coding, processed_transcript	uc001tvw.3	nonsynonymous SNV	exon10	c.C1660T	p.P554S	LNPMDSPHSPISPLPPTLSPQPRGQ	LNPMDSPHSPISSLPPTLSPQPRGQ	9.0	9.0	-	-	3466_12:116446558-116446558 G>A_LNPMDSPHSPISSLPPTLSPQPRGQ	0.0
11:26656570-26656570 C>T	0.0	4301	MELANOMA	-	-	-	-	ANO3	ENST00000537978,p.H650Y|uc010rds.2,p.H505Y|ENST00000525139,p.H650Y|uc010rdt.2,p.H520Y|ENST00000531568,p.H520Y|NM_031418,p.H666Y|uc010rdr.2,p.H650Y|uc001mqt.4,p.H666Y|ENST00000256737,p.H666Y	protein_coding, processed_transcript	uc010rdt.2	nonsynonymous SNV	exon17	c.C1558T	p.H520Y	FYIAFFLGRFVGHPGKYNKLFDRWR	FYIAFFLGRFVGYPGKYNKLFDRWR	2.0	6.0	-	-	4301_11:26656570-26656570 C>T_FYIAFFLGRFVGYPGKYNKLFDRWR	0.0
2:27888105-27888105 G>A	1.0	2369	MELANOMA	-	-	-	-	SLC4A1AP	uc002rlk.4,p.E322K|ENST00000427424,p.E84K|ENST00000326019,p.E322K|NM_018158,p.E322K	retained_intron, protein_coding, nonsense_mediated_decay	uc002rlk.4	nonsynonymous SNV	exon2	c.G964A	p.E322K	EDSDEEEEMDTSERKINAGSQDDEM	EDSDEEEEMDTSKRKINAGSQDDEM	8.0	5.0	-	-	2369_2:27888105-27888105 G>A_EDSDEEEEMDTSKRKINAGSQDDEM	0.0
9:131847564-131847564 C>T	1.0	3466	MELANOMA	-	-	-	-	DOLPP1	NM_001135917,p.S114F|NM_020438,p.S114F|ENST00000406974,p.S114F|uc004bxc.3,p.S114F|ENST00000540102,p.S16F|ENST00000372546,p.S114F|uc004bxd.3,p.S114F	protein_coding, processed_transcript, nonsense_mediated_decay	uc004bxd.3	nonsynonymous SNV	exon4	c.C341T	p.S114F	SHSQFMWFFSVYSFLFLYLRMHQTN	SHSQFMWFFSVYFFLFLYLRMHQTN	5.0	9.0	-	-	3466_9:131847564-131847564 C>T_SHSQFMWFFSVYFFLFLYLRMHQTN	0.0
16:84229288-84229288 C>T	0.0	4213	COLORECTAL	-	-	-	-	ADAD2	uc002fhr.2,p.A346V|ENST00000315906,p.A346V|ENST00000268624,p.A428V|NM_001145400,p.A346V|uc002fhq.2,p.A428V|NM_139174,p.A428V	retained_intron, protein_coding, processed_transcript	uc002fhr.2	nonsynonymous SNV	exon6	c.C1037T	p.A346V	FLHLYISNTPKGAARDIYLPPTSEG	FLHLYISNTPKGVARDIYLPPTSEG	4.0	9.0	-	-	4213_16:84229288-84229288 C>T_FLHLYISNTPKGVARDIYLPPTSEG	0.0
19:51650065-51650065 C>T	0.0	4245	COLORECTAL	-	-	-	-	SIGLEC7	uc002pvw.1,p.A268V|uc002pvv.1,p.A361V|NM_016543,p.A268V|NM_014385,p.A361V|ENST00000305628,p.A268V|ENST00000317643,p.A361V	retained_intron, protein_coding, nonsense_mediated_decay	uc002pvw.1	nonsynonymous SNV	exon4	c.C803T	p.A268V	SGVLLGAVGGAGATALVFLSFCVIF	SGVLLGAVGGAGVTALVFLSFCVIF	6.0	5.0	-	-	4245_19:51650065-51650065 C>T_SGVLLGAVGGAGVTALVFLSFCVIF	0.0
3:164907028-164907028 G>A	0.0	4278	COLORECTAL	-	-	-	-	SLITRK3	ENST00000475390,p.R531W|uc003fek.3,p.R531W|uc003fej.4,p.R531W|NM_014926,p.R531W|uc021xgy.1,p.R531W|ENST00000241274,p.R531W	protein_coding	uc021xgy.1	nonsynonymous SNV	exon1	c.C1591T	p.R531W	LPTDAFAGTSLARLNLRKNYFLYLP	LPTDAFAGTSLAWLNLRKNYFLYLP	3.0	10.0	-	-	4278_3:164907028-164907028 G>A_LPTDAFAGTSLAWLNLRKNYFLYLP	0.0
6:24569093-24569093 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	KIAA0319	NM_001168375,p.V686L|uc010jpt.1,p.V97L|uc011djp.2,p.V641L|NM_001168376,p.V641L|ENST00000543707,p.V686L|ENST00000430948,p.V641L|uc003neh.1,p.V686L|NM_001252328,p.V97L|ENST00000535378,p.V677L|ENST00000378214,p.V686L|ENST00000537886,p.V686L|NM_001168377,p.V686L|uc011djr.1,p.V686L|uc011djo.2,p.V686L|NM_014809,p.V686L|NM_001168374,p.V677L|uc011djq.1,p.V677L	protein_coding	uc011djr.1	nonsynonymous SNV	exon13	c.G2056T	p.V686L	IDKAIATVTGLQVGTYHFRLTVKDQ	IDKAIATVTGLQLGTYHFRLTVKDQ	2.0	7.0	-	-	4258_6:24569093-24569093 C>A_IDKAIATVTGLQLGTYHFRLTVKDQ	0.0
2:74757429-74757429 C>G	0.0	4186	BREAST	-	-	-	-	HTRA2	uc002smj.1,p.S99C|ENST00000258080,p.S99C|NM_013247,p.S99C|uc002smi.1,p.S99C|NM_145074,p.S99C|uc002smk.1,p.S99C|ENST00000437202,p.S86C|uc002sml.1,p.S99C|ENST00000352222,p.S99C	retained_intron, protein_coding, processed_transcript	uc002sml.1	nonsynonymous SNV	exon1	c.C296G	p.S99C	TPDTRTREASENSGTRSRAWLAVAL	TPDTRTREASENCGTRSRAWLAVAL	9.0	8.0	-	-	4186_2:74757429-74757429 C>G_TPDTRTREASENCGTRSRAWLAVAL	0.0
17:56700312-56700312 G>A	0.0	4158	COLORECTAL	-	-	-	-	TEX14	uc010dcz.2,p.L105F|NM_198393,p.L105F|ENST00000240361,p.L105F|NM_031272,p.L105F|uc002iws.2,p.L105F|ENST00000389934,p.L105F|ENST00000349033,p.L105F|NM_001201457,p.L105F|uc002iwr.2,p.L105F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010dcz.2	nonsynonymous SNV	exon4	c.C313T	p.L105F	VHAAAFSGNQWILSKLLDAGGDLRL	VHAAAFSGNQWIFSKLLDAGGDLRL	4.0	1.0	-	-	4158_17:56700312-56700312 G>A_VHAAAFSGNQWIFSKLLDAGGDLRL	0.0
4:57211342-57211342 A>T	0.0	4345	COLORECTAL	-	-	-	-	AASDH	uc010ihb.3,p.L383H|ENST00000434343,p.L383H|NM_181806,p.L868H|uc003hbn.3,p.L868H|uc003hbo.3,p.L768H|NM_001286669,p.L715H|ENST00000513376,p.L768H|ENST00000205214,p.L868H|NM_001286668,p.L768H|uc011cab.2,p.L383H|NM_001286670,p.L383H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cab.2	nonsynonymous SNV	exon9	c.T1148A	p.L383H	VKSSATMDPTTGLIYIGSHDQHAYA	VKSSATMDPTTGHIYIGSHDQHAYA	6.0	3.0	-	-	4345_4:57211342-57211342 A>T_VKSSATMDPTTGHIYIGSHDQHAYA	0.0
16:4924857-4924857 A>G	1.0	3919	MELANOMA	-	-	-	-	UBN1	ENST00000545171,p.N816D|ENST00000590769,p.N816D|ENST00000262376,p.N816D|uc002cyc.3,p.N816D|NM_001288656,p.N816D|NM_001079514,p.N816D|ENST00000396658,p.N816D|uc010uxw.2,p.N816D|uc002cyb.3,p.N816D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uxw.2	nonsynonymous SNV	exon15	c.A2446G	p.N816D	VKVFHAGTQQQKNFTPPSPFANKLQ	VKVFHAGTQQQKDFTPPSPFANKLQ	9.0	2.0	-	-	3919_16:4924857-4924857 A>G_VKVFHAGTQQQKDFTPPSPFANKLQ	0.0
15:89395072-89395072 A>T	0.0	4110	BILE DUCT	-	-	-	-	ACAN	ENST00000561243,p.T692S|NM_013227,p.T692S|ENST00000439576,p.T692S|uc010upp.1,p.T692S|ENST00000559004,p.T692S|uc010upo.1,p.T692S|ENST00000352105,p.T692S|NM_001135,p.T692S	retained_intron, protein_coding	uc010upp.1	nonsynonymous SNV	exon11	c.A2074T	p.T692S	VPSPGEEEGGTPTSPSGVEEWIVTQ	VPSPGEEEGGTPSSPSGVEEWIVTQ	3.0	5.0	-	-	4110_15:89395072-89395072 A>T_VPSPGEEEGGTPSSPSGVEEWIVTQ	0.0
1:110714807-110714807 C>T	0.0	4259	COLORECTAL	-	-	-	-	SLC6A17	NM_001010898,p.R138C|uc009wfq.3,p.R138C|ENST00000331565,p.R138C	protein_coding, processed_transcript	uc009wfq.3	nonsynonymous SNV	exon3	c.C412T	p.R138C	RGSIGVWHYICPRLGGIGFSSCIVC	RGSIGVWHYICPCLGGIGFSSCIVC	3.0	9.0	-	-	4259_1:110714807-110714807 C>T_RGSIGVWHYICPCLGGIGFSSCIVC	0.0
5:140503307-140503307 C>T	0.0	4301	MELANOMA	-	-	-	-	PCDHB4	uc003lip.1,p.P576L|NM_018938,p.P576L|ENST00000194152,p.P576L	protein_coding	uc003lip.1	nonsynonymous SNV	exon1	c.C1727T	p.P576L	LQNGSAPCTELVPRAAEPGYLVTKV	LQNGSAPCTELVLRAAEPGYLVTKV	4.0	7.0	-	-	4301_5:140503307-140503307 C>T_LQNGSAPCTELVLRAAEPGYLVTKV	0.0
9:138379968-138379968 C>A	0.0	4335	COLORECTAL	-	-	-	-	PPP1R26	ENST00000356818,p.S1204R|ENST00000401470,p.S1204R|uc004cfr.1,p.S1204R|ENST00000604351,p.S1204R|uc022bpi.1,p.S1204R|NM_014811,p.S1204R|ENST00000605286,p.S1204R|ENST00000605660,p.S1204R	protein_coding	uc022bpi.1	nonsynonymous SNV	exon1	c.C3612A	p.S1204R	DFSDTSTEDSGGSSVVKV	DFSDTSTEDSGGRSVVKV	5.0	1.0	-	-	4335_9:138379968-138379968 C>A_DFSDTSTEDSGGRSVVKV	0.0
4:104640742-104640742 C>T	0.0	4278	COLORECTAL	-	-	-	-	TACR3	NM_001059,p.G31R|uc003hxe.1,p.G31R|ENST00000304883,p.G31R	protein_coding	uc003hxe.1	nonsynonymous SNV	exon1	c.G91A	p.G31R	ADAVNLTASLAAGAATGAVETGWLQ	ADAVNLTASLAARAATGAVETGWLQ	5.0	3.0	-	-	4278_4:104640742-104640742 C>T_ADAVNLTASLAARAATGAVETGWLQ	0.0
13:103703697-103703697 G>T	0.0	4246	COLORECTAL	-	-	-	-	SLC10A2	ENST00000245312,p.P224H|uc001vpy.4,p.P224H|NM_000452,p.P224H	protein_coding	uc001vpy.4	nonsynonymous SNV	exon4	c.C671A	p.P224H	GGILYQSAWIIAPKLWIIGTIFPVA	GGILYQSAWIIAHKLWIIGTIFPVA	1.0	9.0	-	-	4246_13:103703697-103703697 G>T_GGILYQSAWIIAHKLWIIGTIFPVA	0.0
1:186326733-186326733 A>G	1.0	4196	COLORECTAL	-	-	-	1	TPR	NM_003292,p.L507P|uc010pop.2,p.L583P|ENST00000367478,p.L507P|uc001grv.3,p.L507P	retained_intron, protein_coding, processed_transcript	uc010pop.2	nonsynonymous SNV	exon15	c.T1748C	p.L583P	DLSQQIRVLLMELEEARGNHVIRDE	DLSQQIRVLLMEPEEARGNHVIRDE	10.0	3.0	-	-	4196_1:186326733-186326733 A>G_DLSQQIRVLLMEPEEARGNHVIRDE	0.0
5:32276848-32276848 C>T	0.0	4298	COLORECTAL	-	-	-	-	MTMR12	NM_001294344,p.E28K|uc003jhq.3,p.E28K|NM_001040446,p.E28K|ENST00000280285,p.E28K|ENST00000264934,p.E28K|uc010iul.3,p.E28K|ENST00000382142,p.E28K|uc010iuk.3,p.E28K|NM_001294343,p.E28K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010iul.3	nonsynonymous SNV	exon2	c.G82A	p.E28K	PKPSFVSYVRPEEIHTNEKEVTEKE	PKPSFVSYVRPEKIHTNEKEVTEKE	7.0	5.0	-	-	4298_5:32276848-32276848 C>T_PKPSFVSYVRPEKIHTNEKEVTEKE	0.0
15:52416716-52416716 G>A	1.0	3784	MELANOMA	-	-	-	-	GNB5	uc002abr.1,p.P335L|uc002abt.1,p.P377L|ENST00000396335,p.P265L|uc002abs.1,p.P265L|ENST00000261837,p.P377L|ENST00000358784,p.P335L|NM_016194,p.P377L|NM_006578,p.P335L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002abt.1	nonsynonymous SNV	exon12	c.C1130T	p.P377L	GHENRVSTLRVSPDGTAFCSGSWDH	GHENRVSTLRVSLDGTAFCSGSWDH	5.0	6.0	CD8	-	3784_15:52416716-52416716 G>A_GHENRVSTLRVSLDGTAFCSGSWDH	1.0
13:101264662-101264662 T>C	0.0	4335	COLORECTAL	-	-	-	-	TMTC4	ENST00000376234,p.Q666R|NM_001286453,p.Q555R|ENST00000342624,p.Q685R|ENST00000328767,p.Q555R|uc010tja.2,p.Q555R|uc001vot.3,p.Q685R|NM_001079669,p.Q666R|NM_032813,p.Q685R|uc001vou.3,p.Q666R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tja.2	nonsynonymous SNV	exon14	c.A1664G	p.Q555R	LMFSLANVLGKSQKYKESEALFLKA	LMFSLANVLGKSRKYKESEALFLKA	7.0	3.0	-	-	4335_13:101264662-101264662 T>C_LMFSLANVLGKSRKYKESEALFLKA	0.0
3:10379973-10379973 C>T	0.0	2591	MELANOMA	-	-	-	-	ATP2B2	NM_001683,p.E1058K|NM_001001331,p.E1103K|uc003bvt.3,p.E1103K|ENST00000383800,p.E1058K|ENST00000397077,p.E1058K|uc003bvv.3,p.E1058K|uc003bvw.3,p.E1058K|ENST00000352432,p.E1103K|ENST00000452124,p.E959K|ENST00000343816,p.E1089K|uc010hdo.3,p.E808K|ENST00000460129,p.E1058K|ENST00000360273,p.E1103K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010hdo.3	nonsynonymous SNV	exon18	c.G2422A	p.E808K	FLKEAGRLTQKEEIPEEELNEDVEE	FLKEAGRLTQKEKIPEEELNEDVEE	1.0	9.0	-	-	2591_3:10379973-10379973 C>T_FLKEAGRLTQKEKIPEEELNEDVEE	0.0
1:36784695-36784695 T>G	1.0	4335	COLORECTAL	-	-	-	-	SH3D21	NM_001162530,p.L265V|uc010oia.1,p.L265V|ENST00000480549,p.L105V|ENST00000505871,p.L154V|ENST00000373139,p.L265V|ENST00000426732,p.L149V|NM_024676,p.L154V|ENST00000453908,p.L265V|uc010oib.1,p.L154V	protein_coding, processed_transcript, nonsense_mediated_decay	uc010oib.1	nonsynonymous SNV	exon8	c.T460G	p.L154V	SRESAPIKEPKKLMPKTSLPTVKKL	SRESAPIKEPKKVMPKTSLPTVKKL	7.0	5.0	-	-	4335_1:36784695-36784695 T>G_SRESAPIKEPKKVMPKTSLPTVKKL	0.0
2:179398057-179398057 C>T	0.0	2591	MELANOMA	-	-	-	-	TTN	NM_133378,p.E31861K|uc031rqc.1,p.E34429K|NM_003319,p.E25364K|ENST00000359218,p.E25489K|NM_001256850,p.E32788K|uc031rqd.1,p.E32788K|uc021vtb.2,p.E25364K|uc021vsy.2,p.E31861K|NM_133437,p.E25556K|ENST00000460472,p.E25364K|uc021vta.2,p.E25489K|NM_133432,p.E25489K|NM_001267550,p.E34429K|uc021vsz.2,p.E25556K|ENST00000342992,p.E31861K|ENST00000342175,p.E25556K	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon308	c.G98362A	p.E32788K	DYYALHIRDTLPEDTGYYRVTATNT	DYYALHIRDTLPKDTGYYRVTATNT	1.0	5.0	-	-	2591_2:179398057-179398057 C>T_DYYALHIRDTLPKDTGYYRVTATNT	0.0
10:114912188-114912188 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM1560963,COSM1560962,COSM1560964;OCCURENCE=1(large_intestine)	1	TCF7L2	uc010qrm.2,p.R420W|ENST00000538897,p.R420W|uc010qrx.2,p.R277W|uc021pyj.1,p.R420W|ENST00000470254,p.R51W|ENST00000369389,p.R131W|ENST00000545257,p.R420W|ENST00000543371,p.R420W|uc001laf.4,p.R397W|ENST00000536810,p.R420W|uc010qrk.2,p.R397W|ENST00000542695,p.R136W|uc001lac.4,p.R397W|NM_001146286,p.R397W|NM_001198529,p.R397W|NM_001146284,p.R393W|ENST00000355717,p.R444W|NM_001198526,p.R397W|uc021pyg.1,p.R136W|uc021pyi.1,p.R420W|uc001lah.3,p.R402W|ENST00000277945,p.R137W|uc010qrv.2,p.R237W|uc021pyo.1,p.R425W|ENST00000534894,p.R420W|NM_001198530,p.R363W|uc001lag.4,p.R444W|NM_001198531,p.R420W|ENST00000369386,p.R63W|uc010qrt.2,p.R291W|uc010qrr.2,p.R335W|NM_001146283,p.R444W|uc021pyl.1,p.R402W|NM_001198528,p.R397W|uc021pyh.1,p.R402W|ENST00000352065,p.R397W|uc010qru.2,p.R319W|uc021pyp.1,p.R416W|uc010qrq.2,p.R393W|NM_001198527,p.R393W|uc001lad.4,p.R393W|uc010qrp.2,p.R397W|uc021pym.1,p.R393W|ENST00000355995,p.R420W|uc010qrl.2,p.R397W|ENST00000369397,p.R397W|uc021pyk.1,p.R402W|NM_030756,p.R397W|uc010qrn.2,p.R363W|uc010qro.2,p.R397W|uc010qrw.2,p.R124W|NM_001198525,p.R402W|uc021pyn.1,p.R425W|NM_001146274,p.R420W|NM_001146285,p.R397W|uc001lae.4,p.R420W|uc010qrs.2,p.R291W	protein_coding, processed_transcript, nonsense_mediated_decay	uc021pyp.1	nonsynonymous SNV	exon11	c.C1246T	p.R416W	QLHMQLYPGWSARDNYGKKKKRKRD	QLHMQLYPGWSAWDNYGKKKKRKRD	10.0	9.0	-	-	4196_10:114912188-114912188 C>T_QLHMQLYPGWSAWDNYGKKKKRKRD	0.0
4:110394181-110394181 C>T	1.0	4000	MELANOMA	-	-	-	-	SEC24B	NM_001042734,p.P300L|ENST00000399100,p.P300L|uc003hzk.3,p.P300L|ENST00000265175,p.P300L|ENST00000504968,p.P331L|NM_001300813,p.P331L|uc003hzl.3,p.P300L|uc011cfq.2,p.P300L|uc011cfp.2,p.P331L|NM_006323,p.P300L|uc011cfr.2,p.P300L	protein_coding	uc011cfr.2	nonsynonymous SNV	exon3	c.C899T	p.P300L	NPTITVADSLSCPVMQNVQPPKSSP	NPTITVADSLSCLVMQNVQPPKSSP	9.0	2.0	-	-	4000_4:110394181-110394181 C>T_NPTITVADSLSCLVMQNVQPPKSSP	0.0
14:100795800-100795800 G>A	0.0	4266	COLORECTAL	-	-	-	-	SLC25A47	uc001yhc.3,p.G249R|ENST00000557052,p.G103R|NM_207117,p.G249R|uc001yhd.3,p.G103R|ENST00000361529,p.G249R	protein_coding	uc001yhd.3	nonsynonymous SNV	exon6	c.G307A	p.G103R	PMDVIKSRLQADGQGQRRYRGLLHC	PMDVIKSRLQADRQGQRRYRGLLHC	4.0	7.0	-	-	4266_14:100795800-100795800 G>A_PMDVIKSRLQADRQGQRRYRGLLHC	0.0
6:46661197-46661197 G>A	0.0	4301	MELANOMA	-	-	-	-	TDRD6	NM_001168359,p.E1778K|ENST00000544460,p.E1778K|ENST00000316081,p.E1778K|uc003oyj.3,p.E1778K|uc010jze.3,p.E1778K|NM_001010870,p.E1778K	protein_coding	uc010jze.3	nonsynonymous SNV	exon1	c.G5332A	p.E1778K	SNFRDPKTDNICEGFENPCKDKIDT	SNFRDPKTDNICKGFENPCKDKIDT	4.0	3.0	-	-	4301_6:46661197-46661197 G>A_SNFRDPKTDNICKGFENPCKDKIDT	0.0
12:11214097-11214097 G>C	0.0	4316	COLORECTAL	-	-	-	-	TAS2R46	ENST00000533467,p.A266G|uc001qzp.1,p.A266G|NM_176887,p.A266G	protein_coding	uc001qzp.1	nonsynonymous SNV	exon1	c.C797G	p.A266G	SLENKPVFMFCEAIAFSYPSTHPFI	SLENKPVFMFCEGIAFSYPSTHPFI	3.0	10.0	-	-	4316_12:11214097-11214097 G>C_SLENKPVFMFCEGIAFSYPSTHPFI	0.0
11:134131235-134131235 A>C	0.0	3795	MELANOMA	-	-	-	-	ACAD8	ENST00000543332,p.K205T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000543332	nonsynonymous SNV	exon7	c.A614C	p.K205T	SVILTRDHLNVRKQFGEPLASNQKK	SVILTRDHLNVRTQFGEPLASNQKK	6.0	1.0	-	-	3795_11:134131235-134131235 A>C_SVILTRDHLNVRTQFGEPLASNQKK	0.0
1:75172036-75172036 G>A	1.0	4000	MELANOMA	-	-	-	-	CRYZ	NM_001130042,p.H312Y|NM_001130043,p.H278Y|NM_001889,p.H312Y|NM_001134759,p.H175Y|uc001dgm.3,p.H175Y|ENST00000370871,p.H278Y|ENST00000417775,p.H312Y|ENST00000340866,p.H312Y|uc001dgk.3,p.H312Y|uc001dgl.3,p.H278Y|uc001dgj.3,p.H312Y|ENST00000370872,p.H175Y	protein_coding, processed_transcript	uc001dgm.3	nonsynonymous SNV	exon7	c.C523T	p.H175Y	GSQYPLEKVAEAHENIIHGSGATGK	GSQYPLEKVAEAYENIIHGSGATGK	7.0	7.0	-	-	4000_1:75172036-75172036 G>A_GSQYPLEKVAEAYENIIHGSGATGK	0.0
5:131877804-131877804 C>T	0.0	4278	COLORECTAL	-	-	-	-	IL5	NM_000879,p.G70E|ENST00000450655,p.G36E|uc003kxe.1,p.G70E|ENST00000231454,p.G70E	retained_intron, protein_coding	uc003kxe.1	nonsynonymous SNV	exon3	c.G209A	p.G70E	KNHQLCTEEIFQGIGTLESQTVQGG	KNHQLCTEEIFQEIGTLESQTVQGG	2.0	1.0	-	-	4278_5:131877804-131877804 C>T_KNHQLCTEEIFQEIGTLESQTVQGG	0.0
1:245809494-245809494 G>C	1.0	4237	NSCLC	-	-	-	-	KIF26B	ENST00000366518,p.E343Q|uc010pyq.1,p.E724Q|ENST00000407071,p.E724Q|uc001ibg.1,p.E342Q|uc001ibf.1,p.E724Q|NM_018012,p.E724Q	retained_intron, protein_coding, processed_transcript	uc010pyq.1	nonsynonymous SNV	exon10	c.G2170C	p.E724Q	LGSCVKALSKNREGGSGLCLSLSAL	LGSCVKALSKNRQGGSGLCLSLSAL	7.0	8.0	-	-	4237_1:245809494-245809494 G>C_LGSCVKALSKNRQGGSGLCLSLSAL	0.0
19:4670266-4670266 C>G	0.0	3775	CERVICAL	-	-	-	-	C19orf10	NM_019107,p.R27S|uc002may.3,p.R27S|ENST00000599630,p.R27S|ENST00000262947,p.R27S	retained_intron, protein_coding	uc002may.3	nonsynonymous SNV	exon1	c.G81C	p.R27S	LWAALLLGAVALRPAEAVSEPTTVA	LWAALLLGAVALSPAEAVSEPTTVA	10.0	2.0	-	-	3775_19:4670266-4670266 C>G_LWAALLLGAVALSPAEAVSEPTTVA	0.0
10:49459678-49459678 G>T	0.0	4284	COLORECTAL	-	-	-	-	FRMPD2	uc001jgi.3,p.L28M|uc001jgj.3,p.L19M|ENST00000407470,p.L19M|ENST00000305531,p.L26M|NM_001018071,p.L28M|ENST00000374201,p.L28M|uc001jgh.3,p.L19M	retained_intron, protein_coding, processed_transcript	uc001jgj.3	nonsynonymous SNV	exon2	c.C55A	p.L19M	TLASALQVRGEALSEEEIWSLLFLA	TLASALQVRGEAMSEEEIWSLLFLA	7.0	8.0	-	-	4284_10:49459678-49459678 G>T_TLASALQVRGEAMSEEEIWSLLFLA	0.0
12:112491379-112491379 ->A	0.0	4335	COLORECTAL	-	-	ID=COSM1358815;OCCURENCE=1(large_intestine)	-	NAA25	uc009zwa.2,p.H571fs|ENST00000261745,p.H571fs|uc009zvz.2,p.H543fs|uc001ttm.3,p.H571fs|NM_024953,p.H571fs	retained_intron, protein_coding, nonsense_mediated_decay	uc009zwa.2	frameshift insertion	exon15	c.1710dupT	p.H571fs	ASQSCNFALRFFHSNQKDTSEYIIQ	ASQSCNFALRFFSLQPERYLRIYYSSLQIWCI	6.0	7.0	-	-	4335_12:112491379-112491379 ->A_ASQSCNFALRFFSLQPERYLRIYYSSLQIWCI	0.0
19:8322827-8322827 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1661111;OCCURENCE=1(kidney)	-	CERS4	ENST00000559450,p.S269F|uc002mji.3,p.S105F|NM_024552,p.S269F|ENST00000558331,p.S218F|ENST00000251363,p.S269F|uc002mjg.3,p.S269F	retained_intron, protein_coding, processed_transcript	uc002mji.3	nonsynonymous SNV	exon11	c.C314T	p.S105F	YQQVCDALFLIFSFVFFYTRLVLFP	YQQVCDALFLIFFFVFFYTRLVLFP	9.0	10.0	-	-	3713_19:8322827-8322827 C>T_YQQVCDALFLIFFFVFFYTRLVLFP	0.0
11:58491903-58491903 G>T	0.0	4129	NSCLC	-	-	-	-	GLYAT	ENST00000529732,p.P23T|uc001nnc.3,p.P23T|ENST00000344743,p.P23T|ENST00000278400,p.P23T|NM_005838,p.P23T|uc001nnb.3,p.P23T|NM_201648,p.P23T	retained_intron, protein_coding	uc001nnc.3	nonsynonymous SNV	exon2	c.C67A	p.P23T	LQMLEKSLRKSLPASLKVYGTVFHI	LQMLEKSLRKSLTASLKVYGTVFHI	1.0	8.0	-	-	4129_11:58491903-58491903 G>T_LQMLEKSLRKSLTASLKVYGTVFHI	0.0
5:140869936-140869936 C>T	0.0	4235	COLORECTAL	0.0	-	-	-	PCDHGC5	NM_032407,p.R377W|uc011dbc.2,p.R377W|ENST00000252087,p.R377W|NM_018929,p.R377W|uc003lla.2,p.R377W	protein_coding	uc011dbc.2	nonsynonymous SNV	exon1	c.C1129T	p.R377W	VGTVVGLFNVRDRDSGRNGEVSLDI	VGTVVGLFNVRDWDSGRNGEVSLDI	3.0	9.0	-	-	4235_5:140869936-140869936 C>T_VGTVVGLFNVRDWDSGRNGEVSLDI	0.0
7:97487649-97487649 G>A	0.0	4155	MELANOMA	-	-	-	-	ASNS	NM_133436,p.P282S|ENST00000422745,p.P261S|ENST00000394308,p.P282S|NM_001178077,p.P199S|uc003uox.4,p.P199S|ENST00000175506,p.P282S|ENST00000437628,p.P199S|uc003uov.4,p.P282S|NM_001178075,p.P261S|uc003uou.4,p.P282S|NM_001673,p.P282S|uc003uot.4,p.P282S|ENST00000455086,p.P199S|NM_183356,p.P282S|ENST00000454046,p.P282S|ENST00000444334,p.P261S|ENST00000394309,p.P282S|uc011kin.2,p.P199S|uc011kio.2,p.P261S|NM_001178076,p.P199S	retained_intron, protein_coding, nonsense_mediated_decay	uc011kio.2	nonsynonymous SNV	exon7	c.C781T	p.P261S	LLKQLKEAQVQYPLQTFAIGMEDSP	LLKQLKEAQVQYSLQTFAIGMEDSP	8.0	1.0	-	-	4155_7:97487649-97487649 G>A_LLKQLKEAQVQYSLQTFAIGMEDSP	0.0
19:55107923-55107923 C>T	0.0	4240	BREAST	-	-	ID=COSM3797517;OCCURENCE=2(urinary_tract)	-	LILRA1	uc002qgh.2,p.H410Y|NM_001278319,p.H410Y|NM_006863,p.H410Y|uc010yfh.2,p.H410Y|ENST00000251372,p.H410Y	retained_intron, protein_coding, processed_transcript	uc010yfh.2	nonsynonymous SNV	exon6	c.C1228T	p.H410Y	YGSLSSNPYLLSHPSDSLELMVSGA	YGSLSSNPYLLSYPSDSLELMVSGA	2.0	10.0	-	-	4240_19:55107923-55107923 C>T_YGSLSSNPYLLSYPSDSLELMVSGA	0.0
6:54173655-54173655 C>A	0.0	3795	MELANOMA	-	-	-	-	TINAG	ENST00000370864,p.R85S|ENST00000259782,p.R103S|uc003pcj.2,p.R103S|NM_014464,p.R103S|ENST00000370869,p.R99S|uc003pci.3,p.R103S	protein_coding, processed_transcript	uc003pcj.2	nonsynonymous SNV	exon1	c.C307A	p.R103S	NSDCCPDYKSFCREEKEWPPHTQPW	NSDCCPDYKSFCSEEKEWPPHTQPW	2.0	7.0	-	-	3795_6:54173655-54173655 C>A_NSDCCPDYKSFCSEEKEWPPHTQPW	0.0
2:128386066-128386066 A>G	1.0	4281	COLORECTAL	-	-	-	-	MYO7B	ENST00000409090,p.E354G|ENST00000389524,p.E1501G|uc002tor.1,p.E354G|NM_001080527,p.E1501G|ENST00000428314,p.E1501G|ENST00000409816,p.E1501G|uc002top.3,p.E1501G	retained_intron, protein_coding	uc002tor.1	nonsynonymous SNV	exon8	c.A1061G	p.E354G	AELVALFLEGLKERSIFAMALQDRK	AELVALFLEGLKGRSIFAMALQDRK	8.0	5.0	-	-	4281_2:128386066-128386066 A>G_AELVALFLEGLKGRSIFAMALQDRK	0.0
20:30897865-30897873 TGGACAAAC>-	1.0	4326	BREAST	-	-	-	-	KIF3B	uc010ztv.2,p.95_98del|uc010ztw.2,p.95_98del|ENST00000375712,p.95_98del|uc002wxq.3,p.95_98del|NM_004798,p.95_98del	protein_coding	uc010ztw.2	nonframeshift deletion	exon1	c.285_293del	p.95_98del	SVLQGFNGTIFAYGQTGTGKTYTMEG	SVLQGFNGTIFAYGTGKTYTMEGIR	7.0	3.0	-	-	4326_20:30897865-30897873 TGGACAAAC>-_SVLQGFNGTIFAYGTGKTYTMEGIR	0.0
16:58592488-58592488 C>T	1.0	3919	MELANOMA	-	-	-	-	CNOT1	uc002enz.2,p.G170S|ENST00000441024,p.G741S|ENST00000317147,p.G741S|ENST00000567188,p.G741S|uc002enu.5,p.G741S|ENST00000569882,p.G151S|NM_016284,p.G741S|uc002enx.4,p.G741S|NM_206999,p.G741S|uc002env.4,p.G741S|NM_001265612,p.G741S|ENST00000569240,p.G741S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002enz.2	nonsynonymous SNV	exon9	c.G508A	p.G170S	HTQSMQGFPPNLGSAFSTPQSPAKA	HTQSMQGFPPNLSSAFSTPQSPAKA	9.0	2.0	-	-	3919_16:58592488-58592488 C>T_HTQSMQGFPPNLSSAFSTPQSPAKA	0.0
8:145692885-145692885 G>A	1.0	3903	MELANOMA	-	-	-	-	KIFC2	uc003zcz.3,p.E163K|NM_145754,p.E163K|ENST00000301332,p.E163K	retained_intron, protein_coding, processed_transcript	uc003zcz.3	nonsynonymous SNV	exon5	c.G487A	p.E163K	RPPSPDGSTSQEESPSHFTAVPGEP	RPPSPDGSTSQEKSPSHFTAVPGEP	8.0	1.0	-	-	3903_8:145692885-145692885 G>A_RPPSPDGSTSQEKSPSHFTAVPGEP	0.0
3:10970946-10970946 G>A	0.0	4266	COLORECTAL	-	-	ID=COSM1642045;OCCURENCE=1(stomach)	-	SLC6A11	ENST00000254488,p.R431Q|NM_014229,p.R431Q|uc003bvz.3,p.R431Q	retained_intron, protein_coding	uc003bvz.3	nonsynonymous SNV	exon10	c.G1292A	p.R431Q	VTAVVDMYPKVFRRGYRRELLILAL	VTAVVDMYPKVFQRGYRRELLILAL	1.0	6.0	-	-	4266_3:10970946-10970946 G>A_VTAVVDMYPKVFQRGYRRELLILAL	0.0
X:27766454-27766454 G>T	0.0	4078	GASTRIC	-	-	-	-	DCAF8L2	uc011mjy.2,p.R481M|ENST00000451261,p.R481M|NM_001136533,p.R481M	protein_coding, processed_transcript	uc011mjy.2	nonsynonymous SNV	exon1	c.G1442T	p.R481M	NTTVKGVNFYGPRSEFVVSGSDCGH	NTTVKGVNFYGPMSEFVVSGSDCGH	1.0	10.0	-	-	4078_X:27766454-27766454 G>T_NTTVKGVNFYGPMSEFVVSGSDCGH	0.0
X:32827726-32827726 G>T	0.0	4346	COLORECTAL	-	-	-	-	DMD	NM_004010,p.P55Q|ENST00000288447,p.P170Q|uc004dcy.1,p.P174Q|ENST00000378677,p.P174Q|uc004ddb.1,p.P170Q|uc004dcz.2,p.P55Q|uc004ddf.3,p.P170Q|NM_000109,p.P170Q|uc004dda.1,p.P178Q|ENST00000357033,p.P178Q|NM_004009,p.P174Q|NM_004006,p.P178Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ddf.3	nonsynonymous SNV	exon7	c.C509A	p.P170Q	GLALNALIHSHRPDLFDWNSVVCQQ	GLALNALIHSHRQDLFDWNSVVCQQ	9.0	1.0	-	-	4346_X:32827726-32827726 G>T_GLALNALIHSHRQDLFDWNSVVCQQ	0.0
12:19646803-19646803 T>G	1.0	4320	COLORECTAL	-	-	-	-	AEBP2	uc001ref.2,p.F353V|NM_001267043,p.F137V|ENST00000541908,p.F124V|uc001ree.2,p.F353V|ENST00000360995,p.F137V|ENST00000266508,p.F353V|NM_001114176,p.F353V|uc001reg.2,p.F137V|NM_153207,p.F353V|ENST00000398864,p.F353V	protein_coding	uc001reg.2	nonsynonymous SNV	exon4	c.T409G	p.F137V	SQGGLARHVPTHFSQQNSSKVSSQP	SQGGLARHVPTHVSQQNSSKVSSQP	8.0	2.0	-	-	4320_12:19646803-19646803 T>G_SQGGLARHVPTHVSQQNSSKVSSQP	0.0
15:40750688-40750688 C>T	1.0	3713	MELANOMA	-	-	-	-	BAHD1	NM_014952,p.L9F|uc001zlv.2,p.L9F|uc001zlt.2,p.L9F|ENST00000416165,p.L9F|ENST00000561234,p.L9F|uc010bbp.1,p.L9F|ENST00000560846,p.L9F|uc001zlu.2,p.L9F|NM_001301132,p.L9F	retained_intron, protein_coding	uc010bbp.1	nonsynonymous SNV	exon2	c.C25T	p.L9F	MTHTRRKSLPMLSSGLTGRRE	MTHTRRKSFPMLSSGLTGRRE	4.0	10.0	-	-	3713_15:40750688-40750688 C>T_MTHTRRKSFPMLSSGLTGRRE	0.0
4:183601828-183601828 G>A	0.0	4258	ENDOMETRIAL	-	-	-	-	TENM3	uc003ivd.1,p.G591E|ENST00000511685,p.G591E|NM_001080477,p.G591E|ENST00000406950,p.G591E	retained_intron, protein_coding, processed_transcript	uc003ivd.1	nonsynonymous SNV	exon9	c.G1772A	p.G591E	TTQCIDPQCGGRGICIMGSCACNSG	TTQCIDPQCGGREICIMGSCACNSG	6.0	4.0	-	-	4258_4:183601828-183601828 G>A_TTQCIDPQCGGREICIMGSCACNSG	0.0
2:237233383-237233383 G>A	0.0	4081	COLORECTAL	-	-	-	-	IQCA1	uc002vwb.3,p.A814V|uc010zni.2,p.A765V|NM_024726,p.A806V|NM_001270584,p.A765V|ENST00000309507,p.A803V|uc002vvz.2,p.A806V|ENST00000431676,p.A765V|ENST00000409907,p.A806V|NM_001270585,p.A814V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zni.2	nonsynonymous SNV	exon18	c.C2294T	p.A765V	YAKTPLGKKRALAITGGSTEKAKDK	YAKTPLGKKRALVITGGSTEKAKDK	2.0	5.0	-	-	4081_2:237233383-237233383 G>A_YAKTPLGKKRALVITGGSTEKAKDK	0.0
17:80443426-80443426 G>A	1.0	4252	COLORECTAL	-	-	-	-	NARF	uc002kff.4,p.R283H|ENST00000309794,p.R342H|NM_001038618,p.R283H|uc002kfg.4,p.R342H|uc002kfj.4,p.R294H|NM_001083608,p.R294H|ENST00000457415,p.R388H|ENST00000390006,p.R283H|ENST00000345415,p.R294H|NM_012336,p.R342H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kfj.4	nonsynonymous SNV	exon9	c.G881A	p.R294H	EVTLEKNGEVVLRFAAAYGFRNIQN	EVTLEKNGEVVLHFAAAYGFRNIQN	10.0	5.0	-	-	4252_17:80443426-80443426 G>A_EVTLEKNGEVVLHFAAAYGFRNIQN	0.0
11:73760453-73760453 G>A	0.0	4155	MELANOMA	-	-	ID=COSM364990,COSM364991;OCCURENCE=1(lung)	-	C2CD3	NM_015531,p.P1764S|uc001ouu.2,p.P1764S|ENST00000442398,p.P520S|ENST00000334126,p.P1764S|NM_001286577,p.P1764S|ENST00000313663,p.P1764S|ENST00000414160,p.P572S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ouu.2	nonsynonymous SNV	exon27	c.C5290T	p.P1764S	GECQGQIKVAVSPLESLIHFKEERQ	GECQGQIKVAVSSLESLIHFKEERQ	7.0	2.0	-	-	4155_11:73760453-73760453 G>A_GECQGQIKVAVSSLESLIHFKEERQ	0.0
9:127572437-127572437 C>T	0.0	4158	COLORECTAL	-	-	-	-	OLFML2A	ENST00000373580,p.R569W|uc004bov.3,p.R569W|NM_182487,p.R569W|ENST00000288815,p.R355W|NM_001282715,p.R355W|uc004bow.3,p.R355W	protein_coding	uc004bow.3	nonsynonymous SNV	exon5	c.C1063T	p.R355W	DLSVHRETTWKTRLRRNSYGNCFLV	DLSVHRETTWKTWLRRNSYGNCFLV	6.0	10.0	-	-	4158_9:127572437-127572437 C>T_DLSVHRETTWKTWLRRNSYGNCFLV	0.0
4:173734798-173734798 T>A	0.0	4196	COLORECTAL	-	-	-	-	GALNTL6	uc003isv.3,p.F283I|NM_001034845,p.F283I|ENST00000506823,p.F283I|ENST00000508122,p.F266I	protein_coding, processed_transcript	uc003isv.3	nonsynonymous SNV	exon7	c.T847A	p.F283I	YEAQAGDAMRGAFDWEMYYKRIPIP	YEAQAGDAMRGAIDWEMYYKRIPIP	4.0	5.0	-	-	4196_4:173734798-173734798 T>A_YEAQAGDAMRGAIDWEMYYKRIPIP	0.0
19:55493003-55493003 G>A	0.0	3998	MELANOMA	-	-	-	-	NLRP2	uc010eso.3,p.G136E|ENST00000263437,p.G136E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010eso.3	nonsynonymous SNV	exon5	c.G407A	p.G136E	LERFKTEAQETKGNVICLGKEVFKG	LERFKTEAQETKENVICLGKEVFKG	3.0	9.0	-	-	3998_19:55493003-55493003 G>A_LERFKTEAQETKENVICLGKEVFKG	0.0
1:228465295-228465295 G>A	0.0	3795	MELANOMA	-	-	-	-	OBSCN	uc001hsq.2,p.E2657K|NM_001271223,p.E2657K|uc001hsp.2,p.E16K|ENST00000366706,p.E76K|ENST00000570156,p.E2657K	retained_intron, protein_coding, processed_transcript	uc001hsq.2	nonsynonymous SNV	exon29	c.G7969A	p.E2657K	DGATFSCEVSHDEVPGQWFWEGSKL	DGATFSCEVSHDKVPGQWFWEGSKL	7.0	6.0	-	-	3795_1:228465295-228465295 G>A_DGATFSCEVSHDKVPGQWFWEGSKL	0.0
3:195596389-195596389 G>C	1.0	3775	CERVICAL	-	-	-	-	TNK2	uc003fvr.1,p.Q33E|ENST00000381916,p.Q586E|NM_001010938,p.Q586E|uc003fvt.1,p.Q586E|ENST00000416152,p.Q75E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003fvt.1	nonsynonymous SNV	exon12	c.C1756G	p.Q586E	GGVKREPPPRPPQPAFFTQKPTYDP	GGVKREPPPRPPEPAFFTQKPTYDP	10.0	4.0	-	-	3775_3:195596389-195596389 G>C_GGVKREPPPRPPEPAFFTQKPTYDP	0.0
1:183072496-183072496 A>C	1.0	4320	COLORECTAL	-	-	-	-	LAMC1	uc001gpy.4,p.K151T|ENST00000258341,p.K151T|uc001gpx.3,p.K151T|NM_002293,p.K151T	protein_coding, processed_transcript	uc001gpy.4	nonsynonymous SNV	exon2	c.A452C	p.K151T	LGKAFDITYVRLKFHTSRPESFAIY	LGKAFDITYVRLTFHTSRPESFAIY	10.0	3.0	-	-	4320_1:183072496-183072496 A>C_LGKAFDITYVRLTFHTSRPESFAIY	0.0
19:19656689-19656689 C>T	1.0	4301	MELANOMA	-	-	-	-	CILP2	ENST00000586018,p.P1118L|uc002nmw.4,p.P1118L|NM_153221,p.P1112L|ENST00000291495,p.P1112L|uc002nmv.4,p.P1112L	retained_intron, protein_coding	uc002nmw.4	nonsynonymous SNV	exon8	c.C3353T	p.P1118L	VTFQCREPPAGRPSLFQRLLESPAT	VTFQCREPPAGRLSLFQRLLESPAT	6.0	8.0	-	-	4301_19:19656689-19656689 C>T_VTFQCREPPAGRLSLFQRLLESPAT	0.0
9:113170296-113170296 A>-	1.0	3713	MELANOMA	-	-	-	-	SVEP1	ENST00000297826,p.F454fs|uc010mtz.3,p.F2528fs|uc010mty.3,p.F454fs|NM_153366,p.F2528fs|ENST00000401783,p.F2528fs|ENST00000374469,p.F2505fs	protein_coding, processed_transcript	uc010mtz.3	frameshift deletion	exon38	c.7584delT	p.F2528fs	YGQTVTYSCNRGFRLEGPSALTCLE	YGQTVTYSCNRGFGSKVPVP	2.0	10.0	-	-	3713_9:113170296-113170296 A>-_YGQTVTYSCNRGFGSKVPVP	0.0
X:54028671-54028671 A>T	0.0	4129	NSCLC	-	-	-	-	PHF8	NM_001184897,p.L353Q|uc004dsy.3,p.L353Q|uc004dsu.3,p.L389Q|ENST00000413386,p.L65Q|NM_001184896,p.L389Q|ENST00000357988,p.L389Q|ENST00000322659,p.L353Q|ENST00000338946,p.L353Q|uc004dsx.3,p.L117Q|uc004dsv.3,p.L219Q|NM_015107,p.L353Q|uc004dsw.3,p.L353Q|uc004dst.3,p.L353Q|NM_001184898,p.L353Q|ENST00000338154,p.L353Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004dsy.3	nonsynonymous SNV	exon10	c.T1058A	p.L353Q	EMQLKAYEIEKRLSTADLFRFPNFE	EMQLKAYEIEKRQSTADLFRFPNFE	6.0	10.0	-	-	4129_X:54028671-54028671 A>T_EMQLKAYEIEKRQSTADLFRFPNFE	0.0
2:128758000-128758000 G>A	1.0	3713	MELANOMA	-	-	-	-	SAP130	NM_001145928,p.P326S|uc002tpp.2,p.P326S|uc002tpn.2,p.P87S|ENST00000357702,p.P326S|uc010fmd.2,p.P326S|ENST00000259235,p.P326S|ENST00000259234,p.P300S|NM_024545,p.P326S	protein_coding	uc010fmd.2	nonsynonymous SNV	exon8	c.C976T	p.P326S	ALSRPTLSIQHPPSAAISIQRPAQS	ALSRPTLSIQHPSSAAISIQRPAQS	4.0	2.0	-	-	3713_2:128758000-128758000 G>A_ALSRPTLSIQHPSSAAISIQRPAQS	0.0
7:92733555-92733555 A>C	0.0	4335	COLORECTAL	-	-	ID=COSM1635486;OCCURENCE=1(liver)	-	SAMD9	NM_001193307,p.L619R|uc003umg.3,p.L619R|ENST00000379958,p.L619R|ENST00000446617,p.L619R|uc003umf.3,p.L619R|uc022ahg.1,p.L619R|NM_017654,p.L619R	protein_coding	uc022ahg.1	nonsynonymous SNV	exon1	c.T1856G	p.L619R	SALSLEEINGTILKLKSVTQSSKRL	SALSLEEINGTIRKLKSVTQSSKRL	8.0	5.0	-	-	4335_7:92733555-92733555 A>C_SALSLEEINGTIRKLKSVTQSSKRL	0.0
9:100616375-100616375 C>T	0.0	4284	COLORECTAL	-	-	-	-	FOXE1	NM_004473,p.A60V|uc004axu.3,p.A60V|ENST00000375123,p.A60V	protein_coding	uc004axu.3	nonsynonymous SNV	exon1	c.C179T	p.A60V	PLQRGKPPYSYIALIAMAIAHAPER	PLQRGKPPYSYIVLIAMAIAHAPER	4.0	1.0	-	-	4284_9:100616375-100616375 C>T_PLQRGKPPYSYIVLIAMAIAHAPER	0.0
7:5529563-5529563 G>A	0.0	4240	BREAST	-	-	-	-	FBXL18	ENST00000453700,p.H761Y|uc003soo.2,p.H761Y	protein_coding, nonsense_mediated_decay	uc003soo.2	nonsynonymous SNV	exon5	c.C2281T	p.H761Y	IFFLVCLFETESHSVVQAGVQWRDL	IFFLVCLFETESYSVVQAGVQWRDL	7.0	8.0	-	-	4240_7:5529563-5529563 G>A_IFFLVCLFETESYSVVQAGVQWRDL	0.0
6:73830278-73830278 T>G	0.0	4213	COLORECTAL	-	-	-	-	KCNQ5	ENST00000403813,p.L400V|uc010kat.3,p.L400V|uc011dyk.2,p.L159V|NM_001160130,p.L400V	protein_coding	uc011dyk.2	nonsynonymous SNV	exon7	c.T475G	p.L159V	VSIATWKPHLKALHTCSPTNQKLSF	VSIATWKPHLKAVHTCSPTNQKLSF	4.0	4.0	-	-	4213_6:73830278-73830278 T>G_VSIATWKPHLKAVHTCSPTNQKLSF	0.0
21:22658706-22658706 A>T	0.0	4245	COLORECTAL	-	-	-	-	NCAM2	NM_004540,p.N152I|uc002yld.2,p.N152I|uc011acc.2,p.N177I|ENST00000535285,p.N177I|ENST00000400546,p.N152I	protein_coding, processed_transcript	uc011acc.2	nonsynonymous SNV	exon5	c.A530T	p.N177I	SSPAPAVSWLYHNEEVTTISDNRFA	SSPAPAVSWLYHIEEVTTISDNRFA	5.0	7.0	-	-	4245_21:22658706-22658706 A>T_SSPAPAVSWLYHIEEVTTISDNRFA	0.0
8:133854776-133854776 G>T	1.0	4134	NSCLC	-	-	-	-	PHF20L1	ENST00000395386,p.D802Y|NM_016018,p.D802Y|NM_001277196,p.D776Y|uc011lja.2,p.D776Y|ENST00000220847,p.D189Y|ENST00000395390,p.D777Y|uc003ytt.3,p.D802Y	retained_intron, protein_coding, nonsense_mediated_decay	uc011lja.2	nonsynonymous SNV	exon18	c.G2326T	p.D776Y	LKIGILKNKHHPDLHLWACSGKRKD	LKIGILKNKHHPYLHLWACSGKRKD	10.0	5.0	-	-	4134_8:133854776-133854776 G>T_LKIGILKNKHHPYLHLWACSGKRKD	0.0
3:25665064-25665064 G>T	0.0	4259	COLORECTAL	-	-	-	-	TOP2B	NM_001068,p.A885D|ENST00000435706,p.A885D|uc021wug.1,p.A885D|ENST00000264331,p.A890D|uc011awn.1,p.A890D|ENST00000424225,p.A885D|uc003cdj.3,p.A885D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wug.1	nonsynonymous SNV	exon22	c.C2654A	p.A885D	GTGWACKLPNYDAREIVNNVRRMLD	GTGWACKLPNYDDREIVNNVRRMLD	9.0	8.0	-	-	4259_3:25665064-25665064 G>T_GTGWACKLPNYDDREIVNNVRRMLD	0.0
7:140301261-140301261 G>A	0.0	4298	COLORECTAL	-	-	-	-	DENND2A	uc010lnk.3,p.P313S|ENST00000496613,p.P313S|ENST00000461883,p.P313S|uc010lnj.3,p.P313S|ENST00000275884,p.P313S|ENST00000537639,p.P313S|uc003vvx.3,p.P313S|ENST00000492720,p.P313S|NM_015689,p.P313S|uc003vvw.3,p.P313S	protein_coding, nonsense_mediated_decay	uc010lnk.3	nonsynonymous SNV	exon3	c.C937T	p.P313S	SLPPPPLPSSPPPSSVNRRLWTGRQ	SLPPPPLPSSPPSSSVNRRLWTGRQ	5.0	9.0	-	-	4298_7:140301261-140301261 G>A_SLPPPPLPSSPPSSSVNRRLWTGRQ	0.0
7:107564729-107564729 T>A	1.0	4287	COLORECTAL	-	-	-	-	LAMB1	uc003vev.2,p.N1748Y|uc003vew.2,p.N1724Y|ENST00000222399,p.N1724Y|NM_002291,p.N1724Y|ENST00000393561,p.N1748Y	retained_intron, protein_coding, processed_transcript	uc003vew.2	nonsynonymous SNV	exon33	c.A5170T	p.N1724Y	SADARRKAEMLQNEAKTLLAQANSK	SADARRKAEMLQYEAKTLLAQANSK	9.0	9.0	-	-	4287_7:107564729-107564729 T>A_SADARRKAEMLQYEAKTLLAQANSK	0.0
19:33698435-33698435 C>T	1.0	3998	MELANOMA	-	-	-	-	LRP3	uc010edh.3,p.S756F|NM_002333,p.S756F|ENST00000253193,p.S756F|uc002nuk.4,p.S630F	retained_intron, protein_coding	uc010edh.3	nonsynonymous SNV	exon7	c.C2267T	p.S756F	PLGVCRNPPPPCSPMLEASDDEALL	PLGVCRNPPPPCFPMLEASDDEALL	7.0	7.0	-	-	3998_19:33698435-33698435 C>T_PLGVCRNPPPPCFPMLEASDDEALL	0.0
3:43121963-43121963 C>T	1.0	4160	COLORECTAL	-	-	-	-	POMGNT2	uc021wwn.1,p.V321M|NM_032806,p.V321M|uc003cmr.2,p.V321M|uc003cmq.2,p.V321M|ENST00000344697,p.V321M|ENST00000441964,p.V321M	protein_coding	uc021wwn.1	nonsynonymous SNV	exon1	c.G961A	p.V321M	ALAQEFQMKTVTVSLEDHTFADVVR	ALAQEFQMKTVTMSLEDHTFADVVR	8.0	7.0	-	-	4160_3:43121963-43121963 C>T_ALAQEFQMKTVTMSLEDHTFADVVR	0.0
8:143623482-143623482 G>A	1.0	4326	BREAST	-	-	-	-	BAI1	ENST00000323289,p.G1296D|ENST00000517894,p.G1296D|NM_001702,p.G1296D|uc003ywm.3,p.G1296D	retained_intron, protein_coding, nonsense_mediated_decay	uc003ywm.3	nonsynonymous SNV	exon27	c.G3887A	p.G1296D	SKLHLHGSPRYPGGPLPDFPNHSLT	SKLHLHGSPRYPDGPLPDFPNHSLT	4.0	5.0	-	-	4326_8:143623482-143623482 G>A_SKLHLHGSPRYPDGPLPDFPNHSLT	0.0
20:30522508-30522508 C>T	0.0	4235	COLORECTAL	-	-	-	-	TTLL9	ENST00000535842,p.T274M|uc002wxc.2,p.T176M|ENST00000310998,p.T239M|ENST00000375938,p.T274M|uc010gdx.1,p.T274M|ENST00000375922,p.T216M|NM_001008409,p.T274M	protein_coding	uc010gdx.1	nonsynonymous SNV	exon12	c.C821T	p.T274M	SPDYHPKKGCKWTLQRFRQYLASKH	SPDYHPKKGCKWMLQRFRQYLASKH	3.0	3.0	-	-	4235_20:30522508-30522508 C>T_SPDYHPKKGCKWMLQRFRQYLASKH	0.0
7:51097159-51097159 C>T	1.0	2369	MELANOMA	-	-	-	-	COBL	uc003tpq.4,p.G486E|ENST00000445054,p.G437E|uc003tpr.4,p.G545E|uc011kcl.2,p.G545E|uc003tpp.4,p.G331E|uc003tps.3,p.G602E|ENST00000265136,p.G545E|NM_001287436,p.G602E|NM_015198,p.G545E|uc003tpo.4,p.G87E|ENST00000431948,p.G430E|ENST00000395542,p.G627E	retained_intron, protein_coding	uc011kcl.2	nonsynonymous SNV	exon10	c.G1634A	p.G545E	HGDTDAIPVTFIGEVSDDPVDSGLF	HGDTDAIPVTFIEEVSDDPVDSGLF	6.0	8.0	-	-	2369_7:51097159-51097159 C>T_HGDTDAIPVTFIEEVSDDPVDSGLF	0.0
5:38924622-38924622 A>C	0.0	4155	MELANOMA	-	-	-	-	OSMR	uc003jln.2,p.I657L|ENST00000274276,p.I657L|NM_003999,p.I657L	protein_coding, nonsense_mediated_decay	uc003jln.2	nonsynonymous SNV	exon14	c.A1969C	p.I657L	WKDYSTESQPGFIQGYHVYLKSKAR	WKDYSTESQPGFLQGYHVYLKSKAR	4.0	10.0	-	-	4155_5:38924622-38924622 A>C_WKDYSTESQPGFLQGYHVYLKSKAR	0.0
2:207173100-207173100 C>T	1.0	2556	MELANOMA	-	-	-	-	ZDBF2	ENST00000374423,p.S1283F|uc002vbp.2,p.S1283F|uc031rqy.1,p.S1281F|NM_001285549,p.S1281F|NM_020923,p.S1283F	protein_coding	uc031rqy.1	nonsynonymous SNV	exon7	c.C3842T	p.S1281F	VDLENKIVKPTDSRINFDSHEPLQS	VDLENKIVKPTDFRINFDSHEPLQS	8.0	5.0	-	-	2556_2:207173100-207173100 C>T_VDLENKIVKPTDFRINFDSHEPLQS	0.0
19:9073552-9073552 C>T	0.0	3775	CERVICAL	-	-	-	2	MUC16	ENST00000397910,p.E4632K|uc002mkp.3,p.E4632K|NM_024690,p.E4632K	protein_coding, processed_transcript, nonsense_mediated_decay	uc002mkp.3	nonsynonymous SNV	exon3	c.G13894A	p.E4632K	IILSNVSVGAITEATKMEVPSFDAT	IILSNVSVGAITKATKMEVPSFDAT	4.0	8.0	-	-	3775_19:9073552-9073552 C>T_IILSNVSVGAITKATKMEVPSFDAT	0.0
13:67801893-67801893 C>T	1.0	2556	MELANOMA	-	-	-	-	PCDH9	NM_203487,p.G227E|NM_020403,p.G227E|ENST00000328454,p.G227E|uc001vil.3,p.G227E|uc001vin.3,p.G227E|ENST00000377861,p.G227E|ENST00000377865,p.G227E|ENST00000456367,p.G227E|uc001vik.3,p.G227E|uc010thl.2,p.G227E|ENST00000544246,p.G227E	protein_coding	uc010thl.2	nonsynonymous SNV	exon2	c.G680A	p.G227E	KDTYVMKIKVEDGGTPQKSSTAILQ	KDTYVMKIKVEDEGTPQKSSTAILQ	7.0	2.0	-	-	2556_13:67801893-67801893 C>T_KDTYVMKIKVEDEGTPQKSSTAILQ	0.0
12:70330305-70330305 C>T	0.0	3903	MELANOMA	-	-	-	-	RAB3IP,LINC01481	uc010stn.1,p.P71L|ENST00000299350,p.P71L|ENST00000552032,p.P706L|uc001svu.1,p.P71L|ENST00000547771,p.P695L|ENST00000535034,p.P71L	protein_coding, nonsense_mediated_decay	uc010stn.1	nonsynonymous SNV	exon4	c.C212T	p.P71L	LQVPEITFCEILPCQETYCCPIRGM	LQVPEITFCEILLCQETYCCPIRGM	1.0	4.0	-	-	3903_12:70330305-70330305 C>T_LQVPEITFCEILLCQETYCCPIRGM	0.0
3:132247075-132247075 G>A	0.0	4186	BREAST	0.0009	-	-	-	DNAJC13	uc003eor.3,p.E2142K|ENST00000260818,p.E2142K|NM_015268,p.E2142K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eor.3	nonsynonymous SNV	exon54	c.G6424A	p.E2142K	KADLVPYLLKLLEGIGLENLDSPAA	KADLVPYLLKLLKGIGLENLDSPAA	5.0	6.0	-	-	4186_3:132247075-132247075 G>A_KADLVPYLLKLLKGIGLENLDSPAA	0.0
17:37671997-37671997 G>A	1.0	3309	MELANOMA	-	-	-	1	CDK12	uc010wef.1,p.E927K|uc010cvv.3,p.E928K|ENST00000584632,p.E927K|NM_015083,p.E928K|ENST00000447079,p.E928K|NM_016507,p.E928K|ENST00000430627,p.E928K|uc002hrw.4,p.E928K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wef.1	nonsynonymous SNV	exon9	c.G2779A	p.E927K	AIDVWSCGCILGELFTKKPIFQANL	AIDVWSCGCILGKLFTKKPIFQANL	8.0	4.0	CD8	-	3309_17:37671997-37671997 G>A_AIDVWSCGCILGKLFTKKPIFQANL	1.0
2:180835441-180835441 T>A	0.0	4245	COLORECTAL	-	-	-	-	CWC22	ENST00000295749,p.E361D|uc002unp.2,p.E361D|ENST00000410053,p.E361D|ENST00000404136,p.E361D|uc010frh.1,p.E361D|NM_020943,p.E361D	protein_coding	uc010frh.1	nonsynonymous SNV	exon10	c.A1083T	p.E361D	DHPIILEGLDLVEEDDQFTHMLPLE	DHPIILEGLDLVDEDDQFTHMLPLE	8.0	2.0	-	-	4245_2:180835441-180835441 T>A_DHPIILEGLDLVDEDDQFTHMLPLE	0.0
16:1733515-1733515 G>T	1.0	4234	NSCLC	-	-	-	-	HN1L	uc010uvj.2,p.W17L|uc010uvi.2,p.W17L|ENST00000569765,p.W17L|ENST00000566925,p.W17L|ENST00000562684,p.W17L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uvj.2	nonsynonymous SNV	exon2	c.G50T	p.W17L	PDSEGGRAGSRKWQLLTGSLASTSP	PDSEGGRAGSRKLQLLTGSLASTSP	9.0	10.0	-	-	4234_16:1733515-1733515 G>T_PDSEGGRAGSRKLQLLTGSLASTSP	0.0
19:763526-763526 G>A	1.0	4298	COLORECTAL	-	-	-	-	MISP	NM_173481,p.R659H|uc002lpo.3,p.R659H|ENST00000215582,p.R659H	protein_coding	uc002lpo.3	nonsynonymous SNV	exon5	c.G1976A	p.R659H	INSEVLEAIRVTRHKNAMAERWESR	INSEVLEAIRVTHHKNAMAERWESR	9.0	3.0	-	-	4298_19:763526-763526 G>A_INSEVLEAIRVTHHKNAMAERWESR	0.0
20:2582813-2582813 A>G	0.0	3903	MELANOMA	-	-	-	-	TMC2	ENST00000358864,p.R427G|uc002wgf.1,p.R427G|uc010zpw.1,p.R259G|uc002wgg.1,p.R411G|uc010zpx.1,p.R258G|NM_080751,p.R427G	protein_coding, processed_transcript	uc010zpx.1	nonsynonymous SNV	exon9	c.A772G	p.R258G	QESNKEENIHLTRFLRVLANFLIIC	QESNKEENIHLTGFLRVLANFLIIC	1.0	6.0	-	-	3903_20:2582813-2582813 A>G_QESNKEENIHLTGFLRVLANFLIIC	0.0
7:814737-814737 A>T	1.0	3713	MELANOMA	-	-	-	-	HEATR2	uc010krz.1,p.N726I|uc003sjb.2,p.N106I|NM_017802,p.N726I|ENST00000313147,p.N726I|uc003siz.2,p.N594I|ENST00000403952,p.N151I|ENST00000297440,p.N726I|uc003sjc.2,p.N151I	retained_intron, protein_coding, processed_transcript	uc010krz.1	nonsynonymous SNV	exon11	c.A2177T	p.N726I	SKMTRLISCRIINTFLKTSGGMTDP	SKMTRLISCRIIITFLKTSGGMTDP	6.0	6.0	-	-	3713_7:814737-814737 A>T_SKMTRLISCRIIITFLKTSGGMTDP	0.0
2:54874276-54874276 G>T	1.0	4320	COLORECTAL	-	-	-	-	SPTBN1	NM_003128,p.Q1625H|ENST00000333896,p.Q1612H|uc002rxu.3,p.Q1625H|NM_178313,p.Q1612H|ENST00000356805,p.Q1625H|uc002rxx.3,p.Q1612H	retained_intron, protein_coding	uc002rxx.3	nonsynonymous SNV	exon23	c.G4836T	p.Q1612H	LYMMSEEKAKDEQSAVSMLKKHQIL	LYMMSEEKAKDEHSAVSMLKKHQIL	10.0	10.0	-	-	4320_2:54874276-54874276 G>T_LYMMSEEKAKDEHSAVSMLKKHQIL	0.0
6:139264705-139264705 C>G	1.0	3713	MELANOMA	-	-	-	-	REPS1	uc003qii.3,p.A309P|ENST00000415951,p.A309P|NM_001286612,p.A309P|NM_001128617,p.A309P|ENST00000258062,p.A309P|ENST00000450536,p.A309P|ENST00000529597,p.A295P|ENST00000409812,p.A309P|uc011edr.2,p.A309P|NM_001286611,p.A309P|ENST00000431346,p.A74P|uc003qij.3,p.A309P|uc003qig.4,p.A309P|NM_031922,p.A309P|ENST00000367663,p.A309P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011edr.2	nonsynonymous SNV	exon7	c.G925C	p.A309P	QPDLNGFIPGSAAKEFFTKSKLPIL	QPDLNGFIPGSAPKEFFTKSKLPIL	5.0	8.0	-	-	3713_6:139264705-139264705 C>G_QPDLNGFIPGSAPKEFFTKSKLPIL	0.0
19:7676661-7676661 C>A	0.0	3795	MELANOMA	-	-	-	-	CAMSAP3	uc002mgv.4,p.R428S|NM_001080429,p.R455S|NM_020902,p.R428S|uc002mgu.4,p.R455S|ENST00000160298,p.R428S|ENST00000446248,p.R455S	retained_intron, protein_coding	uc002mgv.4	nonsynonymous SNV	exon11	c.C1282A	p.R428S	DVDVVMGDPVLLRSVSSDSLGPPRP	DVDVVMGDPVLLSSVSSDSLGPPRP	4.0	1.0	-	-	3795_19:7676661-7676661 C>A_DVDVVMGDPVLLSSVSSDSLGPPRP	0.0
14:72190579-72190579 C>T	1.0	3466	MELANOMA	-	-	ID=COSM224470;OCCURENCE=1(skin)	-	SIPA1L1	NM_001284245,p.S1475F|ENST00000555818,p.S1496F|ENST00000358550,p.S1475F|NM_001284247,p.S1496F|NM_015556,p.S1496F|uc001xmu.3,p.S1475F|uc001xms.3,p.S1496F|ENST00000381232,p.S1475F|uc001xmt.3,p.S1475F|uc001xmv.3,p.S1496F|uc010ttm.2,p.S950F|ENST00000537413,p.S950F|NM_001284246,p.S1475F	retained_intron, protein_coding, processed_transcript	uc010ttm.2	nonsynonymous SNV	exon14	c.C2849T	p.S950F	LIGWKKPEGTINSVGFMDTRKRHQS	LIGWKKPEGTINFVGFMDTRKRHQS	10.0	5.0	-	-	3466_14:72190579-72190579 C>T_LIGWKKPEGTINFVGFMDTRKRHQS	0.0
16:67195814-67195816 CGC>-	1.0	4078	GASTRIC	-	-	-	-	FBXL8	NM_018378,p.42_43del|ENST00000519378,p.42_43del|ENST00000258200,p.42_43del|ENST00000519917,p.42_43del|uc002erk.1,p.42_43del	protein_coding, processed_transcript, nonsense_mediated_decay	uc002erk.1	nonframeshift deletion	exon2	c.126_128del	p.42_43del	RVCRAWAAAATCSAVWHDTKISCEC	RVCRAWAAAATCSVWHDTKISCECE	5.0	5.0	-	-	4078_16:67195814-67195816 CGC>-_RVCRAWAAAATCSVWHDTKISCECE	0.0
22:30735137-30735137 G>A	1.0	3784	MELANOMA	-	-	-	-	SF3A1	ENST00000411423,p.S32F	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000411423	nonsynonymous SNV	exon2	c.C95T	p.S32F	KQPLVRRSVRRRSRSQRKR	KQPLVRRSVRRRFRSQRKR	10.0	1.0	-	-	3784_22:30735137-30735137 G>A_KQPLVRRSVRRRFRSQRKR	0.0
10:100481584-100481584 C>A	0.0	4158	COLORECTAL	-	-	-	-	HPSE2	uc001kpo.2,p.E204D|ENST00000370549,p.E204D|NM_001166244,p.E204D	protein_coding	uc001kpo.2	nonsynonymous SNV	exon4	c.G612T	p.E204D	QFSNTYSNLILTEPNNYRTMHGRAV	QFSNTYSNLILTDPNNYRTMHGRAV	2.0	7.0	-	-	4158_10:100481584-100481584 C>A_QFSNTYSNLILTDPNNYRTMHGRAV	0.0
7:27839678-27839678 T>G	1.0	4252	COLORECTAL	-	-	-	-	TAX1BP1	ENST00000409980,p.L578R|ENST00000457186,p.L133R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000457186	nonsynonymous SNV	exon4	c.T398G	p.L133R	WKEQVKIAENVKLELAEVQDNYKLQ	WKEQVKIAENVKRELAEVQDNYKLQ	10.0	10.0	-	-	4252_7:27839678-27839678 T>G_WKEQVKIAENVKRELAEVQDNYKLQ	0.0
20:9360708-9360708 G>A	1.0	2556	MELANOMA	-	-	ID=COSM107774;OCCURENCE=1(skin)	-	PLCB4	ENST00000278655,p.R251Q|uc002wnh.3,p.R98Q|uc021wam.1,p.R251Q|ENST00000414679,p.R251Q|ENST00000378501,p.R251Q|ENST00000378493,p.R251Q|uc010gbw.1,p.R251Q|uc010gbx.3,p.R251Q|NM_182797,p.R251Q|NM_001172646,p.R251Q|NM_000933,p.R251Q|uc021wal.1,p.R251Q|ENST00000378473,p.R251Q|ENST00000334005,p.R251Q	protein_coding, processed_transcript	uc021wam.1	nonsynonymous SNV	exon10	c.G752A	p.R251Q	VDQLVSFLNEHQRDPRLNEILFPFY	VDQLVSFLNEHQQDPRLNEILFPFY	7.0	7.0	-	-	2556_20:9360708-9360708 G>A_VDQLVSFLNEHQQDPRLNEILFPFY	0.0
5:14336772-14336772 G>A	1.0	4329	COLORECTAL	-	-	-	-	TRIO	uc003jfh.1,p.R310Q|uc011cna.1,p.R612Q|ENST00000512070,p.R602Q|NM_007118,p.R661Q|ENST00000513206,p.R394Q|ENST00000344204,p.R661Q|uc003jff.3,p.R661Q|ENST00000509967,p.R612Q|ENST00000537187,p.R661Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cna.1	nonsynonymous SNV	exon11	c.G1835A	p.R612Q	AHQLEDRIQDFVRRVEQRKILLDMS	AHQLEDRIQDFVQRVEQRKILLDMS	10.0	10.0	CD8	-	4329_5:14336772-14336772 G>A_AHQLEDRIQDFVQRVEQRKILLDMS	1.0
2:88285259-88285259 G>T	0.0	4213	COLORECTAL	-	-	-	-	RGPD1	uc021vkn.1,p.A12E|NM_001024457,p.A12E|ENST00000420840,p.A12E	protein_coding, processed_transcript	uc021vkn.1	nonsynonymous SNV	exon1	c.C35A	p.A12E	MNVMGFNTDRLAWTRNKLRGFYFA	MNVMGFNTDRLEWTRNKLRGFYFA	6.0	3.0	-	-	4213_2:88285259-88285259 G>T_MNVMGFNTDRLEWTRNKLRGFYFA	0.0
17:17070735-17070735 C>G	0.0	4158	COLORECTAL	-	-	-	-	MPRIP	uc002gqy.2,p.L786V|uc002gqx.2,p.L786V	retained_intron, protein_coding, processed_transcript	uc002gqy.2	nonsynonymous SNV	exon1	c.C2356G	p.L786V	DAESKHSMSMFTLRGRYEEEIRCVV	DAESKHSMSMFTVRGRYEEEIRCVV	10.0	9.0	-	-	4158_17:17070735-17070735 C>G_DAESKHSMSMFTVRGRYEEEIRCVV	0.0
12:6788646-6788646 G>A	1.0	3466	MELANOMA	-	-	-	1	ZNF384	ENST00000535485,p.P14L|ENST00000319770,p.P14L|NM_001039920,p.P14L|uc010sfh.2,p.P14L|NM_001135734,p.P14L|ENST00000355772,p.P14L|ENST00000396795,p.P14L|uc001qqd.3,p.P14L|ENST00000544482,p.P14L|ENST00000542351,p.P14L|ENST00000540915,p.P14L|ENST00000396799,p.P14L|ENST00000361959,p.P14L|uc001qqa.3,p.P14L|ENST00000436774,p.P14L|ENST00000417772,p.P14L|ENST00000538829,p.P14L|NM_133476,p.P14L|ENST00000396801,p.P14L	protein_coding, processed_transcript	uc010sfh.2	nonsynonymous SNV	exon3	c.C41T	p.P14L	EESHFNSNPYFWPSIPTVSGQIENT	EESHFNSNPYFWLSIPTVSGQIENT	9.0	5.0	-	-	3466_12:6788646-6788646 G>A_EESHFNSNPYFWLSIPTVSGQIENT	0.0
1:104163246-104163246 A>G	0.0	4316	COLORECTAL	-	-	-	-	AMY2A	uc001dut.3,p.Y273C|NM_000699,p.Y273C|ENST00000414303,p.Y273C	protein_coding, processed_transcript	uc001dut.3	nonsynonymous SNV	exon5	c.A818G	p.Y273C	DYFGNGRVTEFKYGAKLGTVIRKWN	DYFGNGRVTEFKCGAKLGTVIRKWN	3.0	5.0	-	-	4316_1:104163246-104163246 A>G_DYFGNGRVTEFKCGAKLGTVIRKWN	0.0
16:86613015-86613015 C>T	1.0	4213	COLORECTAL	-	-	-	-	FOXL1	ENST00000320241,p.A229V|NM_005250,p.A229V|uc002fjr.3,p.A229V	protein_coding	uc002fjr.3	nonsynonymous SNV	exon1	c.C686T	p.A229V	DAGDAAQGAAAVAVGQAARTGDGPG	DAGDAAQGAAAVVVGQAARTGDGPG	6.0	9.0	-	-	4213_16:86613015-86613015 C>T_DAGDAAQGAAAVVVGQAARTGDGPG	0.0
10:114925334-114925334 G>A	1.0	4316	COLORECTAL	-	-	ID=COSM267875,COSM267877,COSM267876;OCCURENCE=3(large_intestine)	1	TCF7L2	NM_001198530,p.A390T|ENST00000355717,p.A471T|uc010qro.2,p.A424T|NM_001146286,p.A424T|uc021pyo.1,p.A452T|uc010qrn.2,p.A390T|ENST00000369389,p.A158T|uc001lag.4,p.A471T|NM_001198531,p.A447T|NM_001146283,p.A471T|uc010qrm.2,p.A447T|uc021pym.1,p.A420T|uc021pyp.1,p.A443T|uc021pyl.1,p.A429T	protein_coding, processed_transcript, nonsense_mediated_decay	uc021pyp.1	nonsynonymous SNV	exon13	c.G1327A	p.A443T	PGETNGEKKSAFATYKVKAAASAHP	PGETNGEKKSAFTTYKVKAAASAHP	10.0	8.0	-	-	4316_10:114925334-114925334 G>A_PGETNGEKKSAFTTYKVKAAASAHP	0.0
1:45205650-45205650 G>A	1.0	2359	MELANOMA	-	-	ID=COSM414888;OCCURENCE=1(urinary_tract)	-	KIF2C	ENST00000372224,p.A16T|uc010olb.2,p.A16T|uc001cmg.4,p.A16T|ENST00000372218,p.A16T|NM_001297655,p.A16T|NM_006845,p.A16T|ENST00000452259,p.A16T	protein_coding, processed_transcript	uc010olb.2	nonsynonymous SNV	exon1	c.G46A	p.A16T	DSSLQARLFPGLAIKIQRSNGLIHS	DSSLQARLFPGLTIKIQRSNGLIHS	8.0	9.0	CD8	-	2359_1:45205650-45205650 G>A_DSSLQARLFPGLTIKIQRSNGLIHS	1.0
5:64824311-64824311 G>A	1.0	3466	MELANOMA	-	-	ID=COSM1718389;OCCURENCE=2(NS)	-	CENPK	ENST00000396679,p.P189S|ENST00000242872,p.P189S|NM_022145,p.P189S|uc003jts.3,p.P189S|uc003jtu.3,p.P189S|ENST00000510693,p.P126S|NM_001267038,p.P189S|ENST00000508421,p.P159S|ENST00000514814,p.P189S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jtu.3	nonsynonymous SNV	exon9	c.C565T	p.P189S	LSTLGEFLEDHFPLPDRSVKKKKKN	LSTLGEFLEDHFSLPDRSVKKKKKN	7.0	9.0	-	-	3466_5:64824311-64824311 G>A_LSTLGEFLEDHFSLPDRSVKKKKKN	0.0
15:40591062-40591062 G>A	0.0	4213	COLORECTAL	-	-	-	-	PLCB2	NM_001284298,p.R263W|uc010bbo.3,p.R263W|ENST00000558588,p.R263W|uc001zld.3,p.R263W|ENST00000456256,p.R263W|NM_001284297,p.R263W|uc010ucm.2,p.R263W|ENST00000260402,p.R263W|ENST00000557821,p.R263W|NM_004573,p.R263W	retained_intron, protein_coding, nonsense_mediated_decay	uc010ucm.2	nonsynonymous SNV	exon9	c.C787T	p.R263W	DSRLNSLLFPPARPDQVQGLIDKYE	DSRLNSLLFPPAWPDQVQGLIDKYE	9.0	10.0	-	-	4213_15:40591062-40591062 G>A_DSRLNSLLFPPAWPDQVQGLIDKYE	0.0
11:5530313-5530313 C>T	0.0	4278	COLORECTAL	0.0023	-	-	-	UBQLN3	ENST00000311659,p.R159Q|uc001may.1,p.R159Q|NM_017481,p.R159Q|ENST00000445998,p.R159Q|uc021qcw.1,p.R159Q	protein_coding	uc021qcw.1	nonsynonymous SNV	exon1	c.G476A	p.R159Q	YRGFPDQPSSLMRQHVSVPEFVTQL	YRGFPDQPSSLMQQHVSVPEFVTQL	1.0	9.0	-	-	4278_11:5530313-5530313 C>T_YRGFPDQPSSLMQQHVSVPEFVTQL	0.0
17:73758832-73758832 G>A	0.0	4235	COLORECTAL	-	-	-	-	GALK1	NM_000154,p.A249V|ENST00000588479,p.A249V|ENST00000225614,p.A249V|ENST00000592997,p.A41V|uc002jpk.3,p.A249V|ENST00000437911,p.A279V	retained_intron, protein_coding, nonsense_mediated_decay	uc002jpk.3	nonsynonymous SNV	exon5	c.C746T	p.A249V	PVRRRQCEEVARALGKESLREVQLE	PVRRRQCEEVARVLGKESLREVQLE	8.0	9.0	CD8	-	4235_17:73758832-73758832 G>A_PVRRRQCEEVARVLGKESLREVQLE	1.0
19:9204290-9204290 G>A	0.0	4284	COLORECTAL	0.0009	-	-	-	OR1M1	uc010xkj.2,p.V124M|ENST00000429566,p.V124M|NM_001004456,p.V124M	protein_coding	uc010xkj.2	nonsynonymous SNV	exon1	c.G370A	p.V124M	SVIIAMMAYDRFVAICHPLHYAKIM	SVIIAMMAYDRFMAICHPLHYAKIM	1.0	9.0	-	-	4284_19:9204290-9204290 G>A_SVIIAMMAYDRFMAICHPLHYAKIM	0.0
1:118165785-118165785 C>T	0.0	3775	CERVICAL	-	-	-	1	FAM46C	uc001ehe.3,p.L99F|NM_017709,p.L99F|uc021osq.1,p.L99F|ENST00000369448,p.L99F	protein_coding	uc021osq.1	nonsynonymous SNV	exon1	c.C295T	p.L99F	GCKDLDLIFHVALPTEAEFQLVRDV	GCKDLDLIFHVAFPTEAEFQLVRDV	8.0	7.0	-	-	3775_1:118165785-118165785 C>T_GCKDLDLIFHVAFPTEAEFQLVRDV	0.0
9:131196807-131196807 G>A	1.0	4320	COLORECTAL	-	-	-	-	CERCAM	NM_016174,p.A484T|uc004buz.4,p.A484T|uc010mxz.3,p.A406T|ENST00000372842,p.A406T|uc004buy.1,p.A406T|NM_001286760,p.A406T|ENST00000372838,p.A484T|uc010mya.1,p.A325T	retained_intron, protein_coding, processed_transcript	uc010mya.1	nonsynonymous SNV	exon8	c.G973A	p.A325T	YWTLAYALRLAGARKLLASQPLRRM	YWTLAYALRLAGTRKLLASQPLRRM	6.0	9.0	-	-	4320_9:131196807-131196807 G>A_YWTLAYALRLAGTRKLLASQPLRRM	0.0
16:24981867-24981874 ATATTTTG>-	1.0	4252	COLORECTAL	-	-	-	-	ARHGAP17	ENST00000571480,p.Q76fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000571480	frameshift deletion	exon4	c.226_233del	p.Q76fs	RRHKKLPLTALAQNMQEASTQLEDS	RRHKKLPLTALAARSIDSAGRLSPGMLETCGDAENQLALELSQHEVFVEKEIVDPLYGI	9.0	3.0	-	-	4252_16:24981867-24981874 ATATTTTG>-_RRHKKLPLTALAARSIDSAGRLSPGMLETCGDAENQLALELSQHEVFVEKEIVDPLYGI	0.0
7:129348939-129348939 G>C	1.0	3775	CERVICAL	-	-	-	-	NRF1	NM_001040110,p.E211Q|uc003vpa.3,p.E211Q|ENST00000353868,p.E211Q|ENST00000223190,p.E211Q|uc003voz.3,p.E211Q|uc011kpa.2,p.E50Q|NM_001293163,p.E211Q|ENST00000393231,p.E211Q|ENST00000393232,p.E211Q|ENST00000393230,p.E211Q|ENST00000311967,p.E211Q|NM_005011,p.E211Q|NM_001293164,p.E50Q|ENST00000539636,p.E50Q|uc003vpb.3,p.E211Q	protein_coding, processed_transcript	uc011kpa.2	nonsynonymous SNV	exon5	c.G148C	p.E50Q	KMTQAQLRAFIPEMLKYSTGRGKPG	KMTQAQLRAFIPQMLKYSTGRGKPG	6.0	9.0	-	-	3775_7:129348939-129348939 G>C_KMTQAQLRAFIPQMLKYSTGRGKPG	0.0
10:64950838-64950838 A>T	1.0	4189	MELANOMA	-	-	-	-	JMJD1C	NM_032776,p.I2036N|uc010qiq.2,p.I1854N|NM_001282948,p.I1854N|ENST00000402544,p.I1799N|uc001jmm.3,p.I1748N|ENST00000542921,p.I1854N|uc001jml.3,p.I1799N|ENST00000399262,p.I2036N|uc001jmn.3,p.I2036N|uc009xpi.3,p.I1854N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qiq.2	nonsynonymous SNV	exon16	c.T5561A	p.I1854N	KKENKELTLENQIKEEREQDNSESP	KKENKELTLENQNKEEREQDNSESP	8.0	6.0	-	-	4189_10:64950838-64950838 A>T_KKENKELTLENQNKEEREQDNSESP	0.0
2:189904199-189904199 C>T	1.0	3466	MELANOMA	-	-	-	-	COL5A2	ENST00000374866,p.E1242K|uc002uqk.3,p.E1242K|NM_000393,p.E1242K|uc010frx.3,p.E818K	retained_intron, protein_coding	uc010frx.3	nonsynonymous SNV	exon35	c.G2452A	p.E818K	TAALGDIMGHYDESMPDPLPEFTED	TAALGDIMGHYDKSMPDPLPEFTED	10.0	3.0	-	-	3466_2:189904199-189904199 C>T_TAALGDIMGHYDKSMPDPLPEFTED	0.0
11:55904280-55904280 C>T	0.0	4240	BREAST	-	-	-	-	OR8J3	NM_001004064,p.M305I|uc010riz.2,p.M305I|ENST00000301529,p.M305I	protein_coding	uc010riz.2	nonsynonymous SNV	exon1	c.G915A	p.M305I	RNNDVNVALKKFMENPCYSFKSM	RNNDVNVALKKFIENPCYSFKSM	1.0	9.0	-	-	4240_11:55904280-55904280 C>T_RNNDVNVALKKFIENPCYSFKSM	0.0
6:143074653-143074653 G>A	1.0	4346	COLORECTAL	-	-	ID=COSM1073992;OCCURENCE=1(endometrium)	-	HIVEP2	ENST00000012134,p.S2311L|NM_006734,p.S2311L|uc003qjd.3,p.S2311L|ENST00000367604,p.S2311L|ENST00000367603,p.S2311L	protein_coding, processed_transcript	uc003qjd.3	nonsynonymous SNV	exon10	c.C6932T	p.S2311L	PSSPRLLMKQSTSEDSLNATEREQE	PSSPRLLMKQSTLEDSLNATEREQE	4.0	4.0	-	-	4346_6:143074653-143074653 G>A_PSSPRLLMKQSTLEDSLNATEREQE	0.0
2:220494796-220494796 C>T	0.0	3775	CERVICAL	-	-	-	-	SLC4A3	uc002vmn.2,p.P205L|ENST00000373762,p.P205L|NM_201574,p.P205L|ENST00000273063,p.P205L|uc002vmo.4,p.P205L	protein_coding, processed_transcript, nonsense_mediated_decay	uc002vmo.4	nonsynonymous SNV	exon6	c.C614T	p.P205L	PHTDKSPQHSSRPCSELRDGDGTTD	PHTDKSPQHSSRLCSELRDGDGTTD	3.0	9.0	-	-	3775_2:220494796-220494796 C>T_PHTDKSPQHSSRLCSELRDGDGTTD	0.0
12:13061296-13061296 G>A	1.0	3678	MELANOMA	-	-	-	-	GPRC5A	NM_003979,p.G38E|ENST00000014914,p.G38E|uc001rba.3,p.G38E|ENST00000534831,p.G38E	retained_intron, protein_coding, processed_transcript	uc001rba.3	nonsynonymous SNV	exon2	c.G113A	p.G38E	AWGIVLETVATAGVVTSVAFMLTLP	AWGIVLETVATAEVVTSVAFMLTLP	8.0	6.0	-	-	3678_12:13061296-13061296 G>A_AWGIVLETVATAEVVTSVAFMLTLP	0.0
1:220236275-220236275 C>T	1.0	4237	NSCLC	-	-	-	-	BPNT1	uc010puh.2,p.G130R|NM_001286149,p.G111R|uc001hma.3,p.G166R|NM_001286151,p.G111R|ENST00000469520,p.G166R|NM_001286150,p.G130R|uc010pug.2,p.G111R|NM_006085,p.G166R|ENST00000322067,p.G166R|ENST00000414869,p.G130R|ENST00000544404,p.G111R|ENST00000463953,p.G130R	retained_intron, protein_coding, processed_transcript	uc010puh.2	nonsynonymous SNV	exon6	c.G388A	p.G130R	YYNYEAGPDAVLGRTIWGVLGLGAF	YYNYEAGPDAVLRRTIWGVLGLGAF	9.0	5.0	CD8	-	4237_1:220236275-220236275 C>T_YYNYEAGPDAVLRRTIWGVLGLGAF	1.0
X:49068710-49068710 C>G	1.0	4317	COLORECTAL	-	-	-	-	CACNA1F	NM_005183,p.G1345A|uc031tjm.1,p.G1280A|NM_001256789,p.G1334A|uc010nip.3,p.G1334A|ENST00000376265,p.G1345A|NM_001256790,p.G1280A|ENST00000376251,p.G1280A|uc004dnb.3,p.G1345A|ENST00000323022,p.G1334A	retained_intron, protein_coding, processed_transcript	uc031tjm.1	nonsynonymous SNV	exon34	c.G3839C	p.G1280A	LIAMIFFIYAVIGMQMFGKVALQDG	LIAMIFFIYAVIAMQMFGKVALQDG	5.0	4.0	-	-	4317_X:49068710-49068710 C>G_LIAMIFFIYAVIAMQMFGKVALQDG	0.0
6:129823850-129823850 A>C	1.0	4246	COLORECTAL	-	-	-	-	LAMA2	uc021zfb.1,p.K2764T|NM_000426,p.K2764T|ENST00000421865,p.K2764T|NM_001079823,p.K2760T	protein_coding, processed_transcript	uc021zfb.1	nonsynonymous SNV	exon59	c.A8291C	p.K2764T	AAESEPALLIGSKQFGLSRNSHIAI	AAESEPALLIGSTQFGLSRNSHIAI	1.0	3.0	-	-	4246_6:129823850-129823850 A>C_AAESEPALLIGSTQFGLSRNSHIAI	0.0
1:155171798-155171798 C>T	1.0	3879	MELANOMA	-	-	-	-	THBS3	NM_007112,p.D376N|uc010pfu.2,p.D256N|ENST00000428962,p.D226N|NM_001252607,p.D367N|ENST00000457183,p.D256N|NM_001252608,p.D256N|uc009wqi.3,p.D367N|ENST00000368378,p.D376N|uc001fix.3,p.D376N	protein_coding, processed_transcript	uc010pfu.2	nonsynonymous SNV	exon8	c.G766A	p.D256N	SKQVCNDIDECNDGNNGGCDPNSIC	SKQVCNDIDECNNGNNGGCDPNSIC	6.0	1.0	-	-	3879_1:155171798-155171798 C>T_SKQVCNDIDECNNGNNGGCDPNSIC	0.0
1:35227616-35227616 A>T	0.0	4329	COLORECTAL	-	-	-	-	GJB4	ENST00000339480,p.K254M|uc001bxw.4,p.K254M|uc001bxv.1,p.K254M|NM_153212,p.K254M	protein_coding	uc001bxw.4	nonsynonymous SNV	exon1	c.A761T	p.K254M	GGHPEDGNSVLMKAGSAPVDAGGYP	GGHPEDGNSVLMMAGSAPVDAGGYP	3.0	3.0	-	-	4329_1:35227616-35227616 A>T_GGHPEDGNSVLMMAGSAPVDAGGYP	0.0
15:54557693-54557693 T>A	0.0	4326	BREAST	-	-	-	-	UNC13C	uc002acl.3,p.F103I|uc021sms.1,p.F1273I|NM_001080534,p.F1273I|ENST00000537900,p.F1271I|ENST00000260323,p.F1273I|ENST00000545554,p.F1273I	retained_intron, protein_coding	uc021sms.1	nonsynonymous SNV	exon9	c.T3817A	p.F1273I	GNLNPVWDEKFYFECHNSTDRIKVR	GNLNPVWDEKFYIECHNSTDRIKVR	3.0	3.0	-	-	4326_15:54557693-54557693 T>A_GNLNPVWDEKFYIECHNSTDRIKVR	0.0
6:72678732-72678732 A>G	0.0	4078	GASTRIC	-	-	ID=COSM241418;OCCURENCE=1(prostate),1(large_intestine)	-	RIMS1	ENST00000521978,p.R71G|ENST00000348717,p.R71G|ENST00000518273,p.R71G|ENST00000520567,p.R71G|NM_014989,p.R71G|ENST00000517960,p.R71G|ENST00000522291,p.R71G|uc003pga.4,p.R71G|ENST00000264839,p.R71G|ENST00000491071,p.R71G	retained_intron, protein_coding, processed_transcript	uc003pga.4	nonsynonymous SNV	exon2	c.A211G	p.R71G	RDMAKPAACKTPRNAENQPHQPSPR	RDMAKPAACKTPGNAENQPHQPSPR	1.0	9.0	-	-	4078_6:72678732-72678732 A>G_RDMAKPAACKTPGNAENQPHQPSPR	0.0
17:7577538-7577538 C>T	1.0	4245	COLORECTAL	-	-	ID=COSM99021,COSM99020,COSM10662,COSM99602,COSM3356964,COSM1640830;OCCURENCE=37(urinary_tract),1(adrenal_gland),2(kidney),17(pancreas),8(liver),5(prostate),154(large_intestine),4(biliary_tract),72(breast),13(skin),7(small_intestine),12(endometrium),1(pituitary),32(ovary),3(cervix),58(haematopoietic_and_lymphoid_tissue),1(pleura),5(thyroid),1(peritoneum),18(lung),37(upper_aerodigestive_tract),2(NS),4(bone),3(vulva),37(oesophagus),45(central_nervous_system),37(stomach)	1	TP53	NM_001276696,p.R209Q|NM_000546,p.R248Q|NM_001276699,p.R89Q|NM_001126116,p.R116Q|NM_001276697,p.R89Q|ENST00000359597,p.R248Q|NM_001276761,p.R209Q|NM_001276760,p.R209Q|NM_001276695,p.R209Q|uc002gii.2,p.R89Q|uc002gio.3,p.R116Q|NM_001126113,p.R248Q|ENST00000413465,p.R248Q|uc010cng.2,p.R89Q|uc031qyq.1,p.R209Q|NM_001276698,p.R89Q|NM_001126112,p.R248Q|NM_001126117,p.R116Q|uc010cnf.2,p.R89Q|uc002gij.3,p.R209Q|uc002gih.3,p.R248Q|ENST00000509690,p.R116Q|ENST00000445888,p.R248Q|ENST00000420246,p.R248Q|NM_001126114,p.R248Q|ENST00000455263,p.R248Q|NM_001126115,p.R116Q|ENST00000269305,p.R248Q|uc002gig.1,p.R248Q|NM_001126118,p.R209Q|uc002gin.3,p.R155Q	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon6	c.G626A	p.R209Q	YMCNSSCMGGMNRRPILTIITLEDS	YMCNSSCMGGMNQRPILTIITLEDS	9.0	10.0	-	-	4245_17:7577538-7577538 C>T_YMCNSSCMGGMNQRPILTIITLEDS	0.0
11:116692113-116692113 G>A	0.0	4346	COLORECTAL	-	-	ID=COSM243004;OCCURENCE=1(prostate)	-	APOA4	NM_000482,p.R221C|ENST00000357780,p.R221C|uc001pps.1,p.R221C	protein_coding	uc001pps.1	nonsynonymous SNV	exon3	c.C661T	p.R221C	KVKIDQTVEELRRSLAPYAQDTQEK	KVKIDQTVEELRCSLAPYAQDTQEK	1.0	6.0	-	-	4346_11:116692113-116692113 G>A_KVKIDQTVEELRCSLAPYAQDTQEK	0.0
10:24896731-24896731 G>A	1.0	3713	MELANOMA	-	-	-	-	ARHGAP21	ENST00000396432,p.P842S|uc009xkl.1,p.P842S|uc001isb.2,p.P842S|NM_020824,p.P842S|ENST00000320481,p.P629S|uc010qdc.1,p.P677S|ENST00000376410,p.P832S|ENST00000446003,p.P842S	retained_intron, protein_coding, processed_transcript	uc010qdc.1	nonsynonymous SNV	exon4	c.C2029T	p.P677S	ASTSQVPSIATVPPCLTTSAPLIRR	ASTSQVPSIATVSPCLTTSAPLIRR	8.0	5.0	-	-	3713_10:24896731-24896731 G>A_ASTSQVPSIATVSPCLTTSAPLIRR	0.0
13:39261510-39261510 C>T	0.0	4275	COLORECTAL	-	-	-	-	FREM2	NM_207361,p.S10F|ENST00000280481,p.S10F|uc001uwv.3,p.S10F	protein_coding, processed_transcript	uc001uwv.3	nonsynonymous SNV	exon1	c.C29T	p.S10F	MHSAGTPGLSSRRTGNSTSFQP	MHSAGTPGLFSRRTGNSTSFQP	7.0	10.0	-	-	4275_13:39261510-39261510 C>T_MHSAGTPGLFSRRTGNSTSFQP	0.0
14:20020135-20020135 C>A	0.0	4266	COLORECTAL	-	-	-	-	POTEM	NM_001145442,p.R29L|ENST00000547848,p.R29L|ENST00000551509,p.R29L|ENST00000547722,p.R29L|uc001vwc.3,p.R29L	protein_coding, nonsense_mediated_decay	uc001vwc.3	nonsynonymous SNV	exon1	c.G86T	p.R29L	PFGLRSKMGKWCRHCFPWCRGSGKS	PFGLRSKMGKWCLHCFPWCRGSGKS	3.0	2.0	-	-	4266_14:20020135-20020135 C>A_PFGLRSKMGKWCLHCFPWCRGSGKS	0.0
3:184045024-184045024 G>A	1.0	3678	MELANOMA	-	-	-	-	EIF4G1	uc003fnv.4,p.R1151Q|uc003fnr.3,p.R986Q|NM_004953,p.R955Q|uc003fnw.3,p.R1157Q|NM_001194947,p.R1157Q|ENST00000424196,p.R1157Q|uc003fnp.3,p.R1150Q|uc010hxy.3,p.R1157Q|ENST00000427845,p.R1064Q|uc003fns.3,p.R1110Q|ENST00000382330,p.R1157Q|NM_001194946,p.R1157Q|uc010hxx.3,p.R1157Q|ENST00000414031,p.R1110Q|ENST00000346169,p.R1150Q|ENST00000319274,p.R1150Q|NM_198242,p.R986Q|NM_001291157,p.R1110Q|uc003fnq.3,p.R1063Q|ENST00000441154,p.R987Q|ENST00000434061,p.R955Q|uc003fnt.3,p.R861Q|ENST00000411531,p.R1111Q|uc003fnx.3,p.R955Q|ENST00000342981,p.R1151Q|ENST00000352767,p.R1157Q|ENST00000392537,p.R1063Q|ENST00000435046,p.R954Q|NM_198244,p.R1063Q|NM_182917,p.R1151Q|NM_198241,p.R1150Q|ENST00000350481,p.R986Q	retained_intron, protein_coding, nonsense_mediated_decay	uc010hxy.3	nonsynonymous SNV	exon24	c.G3470A	p.R1157Q	RRVVQRSSLSRERGEKAGDRGDRLE	RRVVQRSSLSREQGEKAGDRGDRLE	10.0	2.0	-	-	3678_3:184045024-184045024 G>A_RRVVQRSSLSREQGEKAGDRGDRLE	0.0
17:27238156-27238156 A>C	0.0	4345	COLORECTAL	-	-	-	-	PHF12	ENST00000579036,p.L217R|ENST00000577226,p.L730R|NM_001290131,p.L730R|uc002hdi.1,p.L726R|NM_001033561,p.L730R|uc010wbb.1,p.L712R|uc002hdg.1,p.L730R|uc002hdh.1,p.L513R|ENST00000332830,p.L730R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wbb.1	nonsynonymous SNV	exon9	c.T2135G	p.L712R	ANSTAMVDLTNSLRAFMDVNGEIEI	ANSTAMVDLTNSRRAFMDVNGEIEI	9.0	1.0	-	-	4345_17:27238156-27238156 A>C_ANSTAMVDLTNSRRAFMDVNGEIEI	0.0
8:124382135-124382135 C>G	1.0	4134	NSCLC	-	-	-	-	ATAD2	ENST00000287394,p.G286A|uc003yqj.3,p.G286A|uc003yqh.4,p.G286A|NM_014109,p.G286A|uc011lii.2,p.G77A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lii.2	nonsynonymous SNV	exon7	c.G230C	p.G77A	DDDDEDDEDEEDGEEENQKRYYLRQ	DDDDEDDEDEEDAEEENQKRYYLRQ	7.0	6.0	-	-	4134_8:124382135-124382135 C>G_DDDDEDDEDEEDAEEENQKRYYLRQ	0.0
10:72636359-72636359 G>T	1.0	4237	NSCLC	-	-	-	-	SGPL1	uc001jrm.3,p.D503Y|ENST00000373202,p.D503Y|NM_003901,p.D503Y	protein_coding, processed_transcript	uc001jrm.3	nonsynonymous SNV	exon14	c.G1507T	p.D503Y	HARKRVAIQFLKDIRESVTQIMKNP	HARKRVAIQFLKYIRESVTQIMKNP	8.0	3.0	-	-	4237_10:72636359-72636359 G>T_HARKRVAIQFLKYIRESVTQIMKNP	0.0
1:242013754-242013754 T>A	1.0	3879	MELANOMA	-	-	-	-	EXO1	ENST00000437497,p.F9L|ENST00000423131,p.F9L|NM_130398,p.F9L|uc021plj.1,p.F9L|NM_006027,p.F9L|uc001hzh.3,p.F9L|ENST00000450748,p.F9L|ENST00000518483,p.F9L|ENST00000348581,p.F9L|NM_003686,p.F9L|uc009xgq.3,p.F9L|uc021plk.1,p.F9L|ENST00000366548,p.F9L|ENST00000523590,p.F9L	protein_coding, processed_transcript	uc021plk.1	nonsynonymous SNV	exon2	c.T27A	p.F9L	MGIQGLLQFIKEASEPIHVRK	MGIQGLLQLIKEASEPIHVRK	8.0	1.0	-	-	3879_1:242013754-242013754 T>A_MGIQGLLQLIKEASEPIHVRK	0.0
9:94519727-94519727 T>C	0.0	4345	COLORECTAL	-	-	-	-	ROR2	uc004ark.3,p.K97R|uc004arj.2,p.K97R|ENST00000375708,p.K97R|NM_004560,p.K97R	retained_intron, protein_coding, processed_transcript	uc004ark.3	nonsynonymous SNV	exon3	c.A290G	p.K97R	VAGNPPPNVRWLKNDAPVVQEPRRI	VAGNPPPNVRWLRNDAPVVQEPRRI	4.0	3.0	-	-	4345_9:94519727-94519727 T>C_VAGNPPPNVRWLRNDAPVVQEPRRI	0.0
9:124979533-124979533 G>C	0.0	4278	COLORECTAL	-	-	-	-	LHX6	ENST00000340587,p.Q166E|ENST00000394319,p.Q166E|NM_014368,p.Q166E|NM_199160,p.Q166E|ENST00000373755,p.Q137E|uc004blx.4,p.Q166E|uc004bly.4,p.Q166E|uc022bmx.1,p.Q155E|NM_001242333,p.Q155E|ENST00000541397,p.Q155E|NM_001242334,p.Q137E|uc010mvw.3,p.Q137E|ENST00000373754,p.Q137E	protein_coding, processed_transcript	uc022bmx.1	nonsynonymous SNV	exon5	c.C463G	p.Q155E	SRFGTKCARCGRQIYASDWVRRARG	SRFGTKCARCGREIYASDWVRRARG	5.0	9.0	-	-	4278_9:124979533-124979533 G>C_SRFGTKCARCGREIYASDWVRRARG	0.0
15:68653990-68653990 C>T	0.0	3466	MELANOMA	-	-	-	-	ITGA11	ENST00000423218,p.G137E|NM_001004439,p.G137E|uc002ari.3,p.G137E|ENST00000315757,p.G137E|uc010bib.3,p.G137E	retained_intron, protein_coding, processed_transcript	uc010bib.3	nonsynonymous SNV	exon5	c.G410A	p.G137E	WSHECGSSYYTTGMCSRVNSNFRFS	WSHECGSSYYTTEMCSRVNSNFRFS	4.0	5.0	-	-	3466_15:68653990-68653990 C>T_WSHECGSSYYTTEMCSRVNSNFRFS	0.0
4:36109278-36109278 C>A	1.0	4234	NSCLC	-	-	-	-	ARAP2	NM_015230,p.Q1398H|ENST00000303965,p.Q1398H|uc003gsq.2,p.Q1398H	retained_intron, protein_coding, processed_transcript	uc003gsq.2	nonsynonymous SNV	exon27	c.G4194T	p.Q1398H	ERPLHYKENVLEQVLRWSSLAEPGS	ERPLHYKENVLEHVLRWSSLAEPGS	7.0	6.0	-	-	4234_4:36109278-36109278 C>A_ERPLHYKENVLEHVLRWSSLAEPGS	0.0
10:72534084-72534084 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	TBATA	ENST00000456372,p.R240S	protein_coding	ENST00000456372	nonsynonymous SNV	exon6	c.A720T	p.R240S	ELLKKTSLWDSCRQQWLSSFPSP	ELLKKTSLWDSCSQQWLSSFPSP	1.0	9.0	-	-	4258_10:72534084-72534084 T>A_ELLKKTSLWDSCSQQWLSSFPSP	0.0
1:25166413-25166413 C>T	1.0	4000	MELANOMA	-	-	-	-	CLIC4	ENST00000374379,p.P160S|uc001bjo.2,p.P160S|uc001bjp.1,p.P140S|NM_013943,p.P160S|ENST00000488683,p.P160S	protein_coding, processed_transcript, nonsense_mediated_decay	uc001bjp.1	nonsynonymous SNV	exon5	c.C418T	p.P140S	LQKLDEYLNSPLPDEIDENSMEDIK	LQKLDEYLNSPLSDEIDENSMEDIK	10.0	9.0	-	-	4000_1:25166413-25166413 C>T_LQKLDEYLNSPLSDEIDENSMEDIK	0.0
15:50339561-50339561 A>T	0.0	4266	COLORECTAL	-	-	-	-	ATP8B4	uc001zxu.3,p.L63H|ENST00000284509,p.L63H|ENST00000559726,p.L63H|ENST00000557955,p.L63H|ENST00000558906,p.L63H|NM_024837,p.L63H|ENST00000559829,p.L63H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zxu.3	nonsynonymous SNV	exon4	c.T188A	p.L63H	QFQRVANAYFLCLLILQLIPEISSL	QFQRVANAYFLCHLILQLIPEISSL	5.0	1.0	-	-	4266_15:50339561-50339561 A>T_QFQRVANAYFLCHLILQLIPEISSL	0.0
1:178834622-178834622 C>T	0.0	4160	COLORECTAL	-	-	-	-	ANGPTL1	ENST00000367629,p.R97Q|uc001gma.3,p.R97Q|uc001gmb.3,p.R97Q|ENST00000234816,p.R97Q|NM_004673,p.R97Q|uc010pnc.1,p.R19Q|ENST00000444255,p.R97Q	protein_coding	uc010pnc.1	nonsynonymous SNV	exon3	c.G56A	p.R19Q	LENLKDVLSRQKREIDVLQLVVDVD	LENLKDVLSRQKQEIDVLQLVVDVD	3.0	8.0	-	-	4160_1:178834622-178834622 C>T_LENLKDVLSRQKQEIDVLQLVVDVD	0.0
9:130211640-130211640 A>T	1.0	4081	COLORECTAL	-	-	-	-	RPL12	ENST00000361436,p.I71N|NM_000976,p.I71N|uc004bqy.2,p.I71N	protein_coding, processed_transcript	uc004bqy.2	nonsynonymous SNV	exon4	c.T212A	p.I71N	TVKLTIQNRQAQIEVVPSASALIIK	TVKLTIQNRQAQNEVVPSASALIIK	10.0	9.0	-	-	4081_9:130211640-130211640 A>T_TVKLTIQNRQAQNEVVPSASALIIK	0.0
19:36124842-36124842 G>A	1.0	4240	BREAST	-	-	-	-	RBM42	uc002oaq.3,p.R284H|uc002oan.3,p.R313H|ENST00000262633,p.R313H|ENST00000589871,p.R291H|NM_024321,p.R313H|ENST00000588161,p.R283H|ENST00000589559,p.R284H|ENST00000360475,p.R284H|uc002oap.3,p.R283H|ENST00000592202,p.R259H	retained_intron, protein_coding	uc002oaq.3	nonsynonymous SNV	exon6	c.G851A	p.R284H	PLEVVRGLLPPLRIPELLSLRPRPR	PLEVVRGLLPPLHIPELLSLRPRPR	10.0	2.0	-	-	4240_19:36124842-36124842 G>A_PLEVVRGLLPPLHIPELLSLRPRPR	0.0
19:19351423-19351423 G>A	0.0	3775	CERVICAL	-	-	-	-	NCAN	ENST00000538881,p.E592K|ENST00000252575,p.E1141K|NM_004386,p.E1141K|uc002nlz.3,p.E1141K	retained_intron, protein_coding	uc002nlz.3	nonsynonymous SNV	exon12	c.G3421A	p.E1141K	PEEHSFINSFGHENTWIGLNDRIVE	PEEHSFINSFGHKNTWIGLNDRIVE	1.0	9.0	-	-	3775_19:19351423-19351423 G>A_PEEHSFINSFGHKNTWIGLNDRIVE	0.0
X:153128279-153128279 C>A	0.0	4246	COLORECTAL	-	-	-	-	L1CAM	uc004fjc.4,p.D1201Y|ENST00000361981,p.D1196Y|ENST00000370057,p.D1205Y|uc004fjb.4,p.D1205Y|NM_000425,p.D1205Y|ENST00000370060,p.D1205Y|ENST00000543994,p.D1207Y|NM_001143963,p.D1196Y|NM_001278116,p.D1205Y|ENST00000361699,p.D1201Y|uc031tks.1,p.D1205Y|NM_024003,p.D1201Y|ENST00000370058,p.D101Y|ENST00000538883,p.D1203Y|uc010nuo.4,p.D1196Y|ENST00000370055,p.D1196Y	retained_intron, protein_coding, processed_transcript	uc031tks.1	nonsynonymous SNV	exon29	c.G3613T	p.D1205Y	PSLNGDIKPLGSDDSLADYGGSVDV	PSLNGDIKPLGSYDSLADYGGSVDV	1.0	8.0	-	-	4246_X:153128279-153128279 C>A_PSLNGDIKPLGSYDSLADYGGSVDV	0.0
2:215835040-215835040 C>T	0.0	3903	MELANOMA	-	-	ID=COSM226040;OCCURENCE=1(NS)	-	ABCA12	uc010zjn.2,p.E810K|uc002vev.3,p.E1565K|ENST00000389661,p.E1565K|uc002vew.3,p.E1883K|NM_015657,p.E1565K|ENST00000272895,p.E1883K|NM_173076,p.E1883K	protein_coding	uc010zjn.2	nonsynonymous SNV	exon39	c.G2428A	p.E810K	SQVIYNLTGQRVENYLISTANEFVQ	SQVIYNLTGQRVKNYLISTANEFVQ	1.0	2.0	-	-	3903_2:215835040-215835040 C>T_SQVIYNLTGQRVKNYLISTANEFVQ	0.0
7:99170553-99170553 T>A	1.0	4000	MELANOMA	-	-	-	-	ZNF655	uc010lga.3,p.D309E|ENST00000424881,p.D309E|NM_001083956,p.D309E|ENST00000493277,p.D309E|ENST00000394163,p.D274E|NM_138494,p.D274E|uc003urh.3,p.D274E|NM_001085368,p.D309E|uc010lgd.3,p.D111E|uc003urk.3,p.D111E|uc003urj.3,p.D274E|uc010lgc.3,p.D309E|ENST00000252713,p.D274E|NM_001009960,p.D274E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010lgd.3	nonsynonymous SNV	exon3	c.T333A	p.D111E	HTREKPYKCEASDKSCEASDKSCSP	HTREKPYKCEASEKSCEASDKSCSP	9.0	6.0	-	-	4000_7:99170553-99170553 T>A_HTREKPYKCEASEKSCEASDKSCSP	0.0
5:50091070-50091070 G>C	1.0	4252	COLORECTAL	-	-	-	-	PARP8	NM_024615,p.R416T|ENST00000505554,p.R395T|ENST00000514067,p.R416T|NM_001178055,p.R416T|ENST00000503750,p.R416T|uc011cpz.2,p.R308T|ENST00000281631,p.R416T|ENST00000514342,p.R169T|ENST00000505697,p.R416T|uc003jop.3,p.R416T|NM_001178056,p.R416T|uc003joo.3,p.R416T|uc003jon.4,p.R416T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cpz.2	nonsynonymous SNV	exon11	c.G923C	p.R308T	HKLLSRSYSSNLRMEELYGLKNHKL	HKLLSRSYSSNLTMEELYGLKNHKL	8.0	1.0	-	-	4252_5:50091070-50091070 G>C_HKLLSRSYSSNLTMEELYGLKNHKL	0.0
X:32841428-32841428 A>C	0.0	4158	COLORECTAL	-	-	-	-	DMD	ENST00000357033,p.I114R|ENST00000288447,p.I106R|uc004dda.1,p.I114R|NM_004006,p.I114R|ENST00000378677,p.I110R|NM_004009,p.I110R|uc004ddb.1,p.I106R|uc004dcy.1,p.I110R|uc004ddf.3,p.I106R|NM_000109,p.I106R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ddf.3	nonsynonymous SNV	exon5	c.T317G	p.I106R	GNHKLTLGLIWNIILHWQVKNVMKN	GNHKLTLGLIWNRILHWQVKNVMKN	5.0	6.0	-	-	4158_X:32841428-32841428 A>C_GNHKLTLGLIWNRILHWQVKNVMKN	0.0
13:108861761-108861761 C>A	0.0	4126	NSCLC	-	-	-	-	LIG4	NM_002312,p.G619V|ENST00000405925,p.G619V|ENST00000442234,p.G619V|uc021rmk.1,p.G619V|NM_206937,p.G619V|ENST00000356922,p.G619V|NM_001098268,p.G619V|uc001vqp.3,p.G619V|uc010agf.3,p.G619V|uc001vqo.3,p.G619V|uc001vqn.3,p.G619V|uc010agg.1,p.G552V	protein_coding	uc021rmk.1	nonsynonymous SNV	exon1	c.G1856T	p.G619V	SGKLASKHLYIGGDDEPQEKKRKAA	SGKLASKHLYIGVDDEPQEKKRKAA	4.0	2.0	-	-	4126_13:108861761-108861761 C>A_SGKLASKHLYIGVDDEPQEKKRKAA	0.0
6:109954238-109954238 G>A	1.0	3998	MELANOMA	-	-	-	-	AK9	NM_145025,p.P381L|ENST00000368948,p.P381L|ENST00000424296,p.P381L|uc003ptr.4,p.P381L|uc003ptn.2,p.P381L|NM_001145128,p.P381L|ENST00000285397,p.P381L	retained_intron, protein_coding	uc003ptr.4	nonsynonymous SNV	exon12	c.C1142T	p.P381L	EEALKPFLLNPRPYLLPPMPGPPCK	EEALKPFLLNPRLYLLPPMPGPPCK	5.0	10.0	-	-	3998_6:109954238-109954238 G>A_EEALKPFLLNPRLYLLPPMPGPPCK	0.0
19:11304307-11304307 G>A	1.0	3713	MELANOMA	-	-	-	-	KANK2	uc002mqo.4,p.P150L|uc002mqm.3,p.P150L|uc021upe.1,p.P150L|ENST00000586659,p.P150L|ENST00000589894,p.P150L|NM_001136191,p.P150L|ENST00000355150,p.P150L|ENST00000432929,p.P150L|uc002mqq.3,p.P150L|ENST00000589359,p.P150L|NM_015493,p.P150L	retained_intron, protein_coding, processed_transcript	uc021upe.1	nonsynonymous SNV	exon3	c.C449T	p.P150L	QAATPTGLGSLTPSAAGSTASLVGV	QAATPTGLGSLTLSAAGSTASLVGV	9.0	10.0	-	-	3713_19:11304307-11304307 G>A_QAATPTGLGSLTLSAAGSTASLVGV	0.0
5:140743948-140743948 C>A	0.0	4235	COLORECTAL	-	-	-	-	PCDHGA5	uc003lju.2,p.F17L|NM_018918,p.F17L|ENST00000518069,p.F17L|NM_032054,p.F17L|uc011das.2,p.F17L	protein_coding	uc011das.2	nonsynonymous SNV	exon1	c.C51A	p.F17L	PRGWGCGELLLPFMLLGTLCEPGSG	PRGWGCGELLLPLMLLGTLCEPGSG	4.0	8.0	-	-	4235_5:140743948-140743948 C>A_PRGWGCGELLLPLMLLGTLCEPGSG	0.0
12:6703638-6703638 G>A	1.0	3713	MELANOMA	-	-	-	1	CHD4	ENST00000544040,p.S760F|NM_001273,p.S767F|uc001qpo.3,p.S767F|uc001qpp.3,p.S764F|ENST00000544484,p.S764F|NM_001297553,p.S760F|ENST00000309577,p.S767F|ENST00000357008,p.S767F|uc001qpn.3,p.S760F	retained_intron, protein_coding, processed_transcript	uc001qpp.3	nonsynonymous SNV	exon15	c.C2291T	p.S764F	LGKTVQTAVFLYSLYKEGHSKGPFL	LGKTVQTAVFLYFLYKEGHSKGPFL	9.0	6.0	-	-	3713_12:6703638-6703638 G>A_LGKTVQTAVFLYFLYKEGHSKGPFL	0.0
20:42788852-42788852 G>A	0.0	4078	GASTRIC	-	-	-	-	JPH2	uc002xli.1,p.S192L|NM_020433,p.S192L|ENST00000372980,p.S192L	protein_coding	uc002xli.1	nonsynonymous SNV	exon2	c.C575T	p.S192L	PASPASDGPALPSPAIPRGGFALSL	PASPASDGPALPLPAIPRGGFALSL	4.0	8.0	-	-	4078_20:42788852-42788852 G>A_PASPASDGPALPLPAIPRGGFALSL	0.0
13:23929383-23929383 G>C	0.0	4335	COLORECTAL	-	-	-	-	SACS	uc001uoq.1,p.S309R|uc001uoo.3,p.S309R|uc001uop.1,p.S243R|NM_001278055,p.S309R|uc001uon.3,p.S456R|ENST00000423156,p.S80R|NM_014363,p.S456R|ENST00000382292,p.S456R|ENST00000382298,p.S456R	protein_coding, processed_transcript	uc001uoq.1	nonsynonymous SNV	exon4	c.C927G	p.S309R	AFCFLPLPPGEESSTGLPVHISGFF	AFCFLPLPPGEERSTGLPVHISGFF	5.0	8.0	-	-	4335_13:23929383-23929383 G>C_AFCFLPLPPGEERSTGLPVHISGFF	0.0
1:117487502-117487502 C>T	1.0	4259	COLORECTAL	-	-	-	-	PTGFRN	NM_020440,p.P207L|ENST00000393203,p.P207L|uc001egv.1,p.P207L	protein_coding, processed_transcript	uc001egv.1	nonsynonymous SNV	exon3	c.C620T	p.P207L	SVLALTHEGRFHPGLGYEQRYHSGD	SVLALTHEGRFHLGLGYEQRYHSGD	10.0	8.0	-	-	4259_1:117487502-117487502 C>T_SVLALTHEGRFHLGLGYEQRYHSGD	0.0
9:135545422-135545422 C>T	0.0	3466	MELANOMA	-	-	-	-	DDX31	ENST00000372153,p.R72K|ENST00000310532,p.R72K|uc004cbq.1,p.R72K|NM_022779,p.R72K|ENST00000372159,p.R72K|uc004cbs.2,p.R72K|uc004cbr.1,p.R72K|uc010mzu.1,p.R72K|NM_138620,p.R72K	protein_coding, processed_transcript	uc010mzu.1	nonsynonymous SNV	exon1	c.G215A	p.R72K	TSPYSWSRSGPGRGGGAGSSRVPRG	TSPYSWSRSGPGKGGGAGSSRVPRG	5.0	9.0	-	-	3466_9:135545422-135545422 C>T_TSPYSWSRSGPGKGGGAGSSRVPRG	0.0
11:104874010-104874010 ->T	1.0	4244	COLORECTAL	-	-	-	-	CASP5	uc010rvc.1,p.N36fs|NM_004347,p.N178fs|uc010rva.1,p.N178fs|NM_001136110,p.N36fs|ENST00000260315,p.N178fs|ENST00000444749,p.N120fs|ENST00000418434,p.N36fs|NM_001136112,p.N191fs|ENST00000526056,p.N191fs|uc010rvb.1,p.N120fs|ENST00000393141,p.N191fs|ENST00000531367,p.N36fs|NM_001136109,p.N120fs|ENST00000456094,p.N162fs|uc010ruz.1,p.N191fs	protein_coding, nonsense_mediated_decay	uc010rvc.1	frameshift insertion	exon2	c.107dupA	p.N36fs	CPREEFLRLCKKNHDEIYPIKKRED	CPREEFLRLCKKKS	7.0	2.0	-	-	4244_11:104874010-104874010 ->T_CPREEFLRLCKKKS	0.0
16:15931836-15931836 C>T	0.0	4186	BREAST	-	-	-	1	MYH11	uc002deb.3,p.E92K|ENST00000576790,p.E92K|uc002ddw.3,p.E92K|NM_022844,p.E92K|ENST00000452625,p.E92K|ENST00000338282,p.E92K|NM_001040113,p.E92K|uc002ddv.3,p.E92K|NM_002474,p.E92K|NM_001040114,p.E92K|ENST00000300036,p.E92K|uc002ddy.3,p.E92K|uc002ddx.3,p.E92K|ENST00000396324,p.E92K	retained_intron, protein_coding, processed_transcript	uc002deb.3	nonsynonymous SNV	exon2	c.G274A	p.E92K	NPPKFSKVEDMAELTCLNEASVLHN	NPPKFSKVEDMAKLTCLNEASVLHN	2.0	6.0	-	-	4186_16:15931836-15931836 C>T_NPPKFSKVEDMAKLTCLNEASVLHN	0.0
1:94652129-94652129 C>T	1.0	3713	MELANOMA	-	-	-	-	ARHGAP29	NM_004815,p.R569Q|ENST00000552844,p.R569Q|uc001dqk.3,p.R135Q|uc001dqj.4,p.R569Q|ENST00000260526,p.R569Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001dqk.3	nonsynonymous SNV	exon4	c.G404A	p.R135Q	SISPGDFHRKLPRTPSSGTMSSADD	SISPGDFHRKLPQTPSSGTMSSADD	3.0	8.0	-	-	3713_1:94652129-94652129 C>T_SISPGDFHRKLPQTPSSGTMSSADD	0.0
20:33875094-33875096 CTC>-	0.0	4196	COLORECTAL	-	-	-	-	FAM83C	uc021wck.1,p.496_496del|ENST00000374408,p.496_496del|NM_178468,p.496_496del|uc002xcb.1,p.151_151del	protein_coding	uc021wck.1	nonframeshift deletion	exon4	c.1486_1488del	p.496_496del	VPGTTLETVEEKEKKASPSQSRGQL	VPGTTLETVEEKKKASPSQSRGQLD	3.0	5.0	-	-	4196_20:33875094-33875096 CTC>-_VPGTTLETVEEKKKASPSQSRGQLD	0.0
9:141010080-141010080 G>A	0.0	4081	COLORECTAL	-	-	-	-	CACNA1B	uc031tfz.1,p.R1909Q|uc004coi.3,p.R1121Q|NM_000718,p.R1909Q|NM_001243812,p.R1909Q|ENST00000371357,p.R1908Q|ENST00000277549,p.R1103Q|ENST00000277551,p.R1909Q|ENST00000371372,p.R1909Q|ENST00000371363,p.R1907Q|uc031tfy.1,p.R1909Q|ENST00000371355,p.R1910Q	protein_coding	uc031tfz.1	nonsynonymous SNV	exon42	c.G5726A	p.R1909Q	LEQTQPAVLRGARVFLRQKSSTSLS	LEQTQPAVLRGAQVFLRQKSSTSLS	1.0	8.0	-	-	4081_9:141010080-141010080 G>A_LEQTQPAVLRGAQVFLRQKSSTSLS	0.0
20:58348469-58348469 A>G	0.0	4252	COLORECTAL	-	-	-	-	PHACTR3	NM_001199506,p.E255G|ENST00000355648,p.E255G|ENST00000395636,p.E255G|ENST00000541461,p.E255G|ENST00000361300,p.E185G|uc002yau.3,p.E296G|ENST00000359926,p.E293G|uc010zzw.2,p.E255G|uc002yav.3,p.E255G|NM_001199505,p.E293G|uc002yax.3,p.E185G|NM_080672,p.E296G|ENST00000395639,p.E185G|NM_183246,p.E185G|ENST00000371015,p.E296G|uc002yaw.3,p.E255G|NM_183244,p.E255G|NM_001281507,p.E255G|uc002yat.3,p.E293G	retained_intron, protein_coding	uc010zzw.2	nonsynonymous SNV	exon6	c.A764G	p.E255G	VHRPLPPSRVIEELHRALATKHRQD	VHRPLPPSRVIEGLHRALATKHRQD	8.0	10.0	-	-	4252_20:58348469-58348469 A>G_VHRPLPPSRVIEGLHRALATKHRQD	0.0
19:4322957-4323011 CCCACCCCTCCTGCCCTGCGCCACAGGGGACACGCTGATCGACGGCGGGGAGCAT>-	0.0	4326	BREAST	-	-	-	-	FSD1	NM_024333,p.G347fs|uc002maa.2,p.G160fs|uc002lzy.2,p.G347fs|ENST00000221856,p.G347fs	retained_intron, protein_coding, processed_transcript	uc002maa.2	frameshift deletion	exon5	c.479_507del	p.G160fs	RDRFTAESYTVLGDTLIDGGEHYWEV	RDRFTAESYTVLVLGGALRAGQQGVRRGRGLPQPGPLRATGQDGRLLVPARQQLAAGQLHGQARQQGQGAGRPRARLPGCAL	4.0	5.0	-	-	4326_19:4322957-4323011 CCCACCCCTCCTGCCCTGCGCCACAGGGGACACGCTGATCGACGGCGGGGAGCAT>-_RDRFTAESYTVLVLGGALRAGQQGVRRGRGLPQPGPLRATGQDGRLLVPARQQLAAGQLHGQARQQGQGAGRPRARLPGCAL	0.0
14:81574915-81574915 G>A	1.0	4000	MELANOMA	-	-	-	1	TSHR	NM_001142626,p.G239S|uc010tvs.2,p.G239S|ENST00000554435,p.G239S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tvs.2	nonsynonymous SNV	exon9	c.G715A	p.G239S	GPSLLVENVAVSGKGFCKSLFSWLY	GPSLLVENVAVSSKGFCKSLFSWLY	5.0	8.0	-	-	4000_14:81574915-81574915 G>A_GPSLLVENVAVSSKGFCKSLFSWLY	0.0
17:48456544-48456544 G>A	1.0	3713	MELANOMA	-	-	-	-	EME1	uc010dbp.2,p.A410T|ENST00000511648,p.A410T|ENST00000338165,p.A397T|NM_001166131,p.A410T|ENST00000393271,p.A410T|uc002iqs.2,p.A397T|NM_152463,p.A397T	retained_intron, protein_coding, nonsense_mediated_decay	uc010dbp.2	nonsynonymous SNV	exon6	c.G1228A	p.A410T	KQTKKQQQRQPEASIGSMVSRVDAE	KQTKKQQQRQPETSIGSMVSRVDAE	5.0	3.0	-	-	3713_17:48456544-48456544 G>A_KQTKKQQQRQPETSIGSMVSRVDAE	0.0
1:115280677-115280677 T>G	1.0	4317	COLORECTAL	-	-	-	-	CSDE1	ENST00000369530,p.E118D|ENST00000339438,p.E72D|NM_001242891,p.E118D|uc001efm.3,p.E118D|uc001efk.3,p.E72D|uc001efl.3,p.E72D|ENST00000438362,p.E118D|uc001efn.3,p.E72D|NM_001242893,p.E72D|uc001efi.3,p.E118D|NM_001242892,p.E72D|ENST00000358528,p.E72D|ENST00000534699,p.E72D|ENST00000534389,p.E72D|NM_001007553,p.E72D|ENST00000261443,p.E72D|uc009wgv.3,p.E72D|NM_007158,p.E72D|NM_001130523,p.E118D	retained_intron, protein_coding, processed_transcript	uc009wgv.3	nonsynonymous SNV	exon3	c.A216C	p.E72D	LQDLKVGDDVEFEVSSDRRTGKPIA	LQDLKVGDDVEFDVSSDRRTGKPIA	10.0	1.0	-	-	4317_1:115280677-115280677 T>G_LQDLKVGDDVEFDVSSDRRTGKPIA	0.0
14:38061213-38061213 T>C	1.0	4240	BREAST	-	-	-	1	FOXA1	ENST00000250448,p.Y259C|uc001wuf.4,p.Y259C|ENST00000540786,p.Y226C|NM_004496,p.Y259C|uc010tpz.3,p.Y226C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010tpz.3	nonsynonymous SNV	exon2	c.A677G	p.Y226C	HPDSGNMFENGCYLRRQKRFKCEKQ	HPDSGNMFENGCCLRRQKRFKCEKQ	10.0	10.0	-	-	4240_14:38061213-38061213 T>C_HPDSGNMFENGCCLRRQKRFKCEKQ	0.0
5:140725167-140725167 G>A	0.0	4158	COLORECTAL	-	-	ID=COSM1650384,COSM590190;OCCURENCE=1(lung)	-	PCDHGA3	NM_032011,p.E523K|uc011dap.2,p.E523K|ENST00000253812,p.E523K|NM_018916,p.E523K|uc003ljm.2,p.E523K	protein_coding	uc011dap.2	nonsynonymous SNV	exon1	c.G1567A	p.E523K	TGVLYALRSFDYEQFRDLKLLVTAS	TGVLYALRSFDYKQFRDLKLLVTAS	4.0	5.0	-	-	4158_5:140725167-140725167 G>A_TGVLYALRSFDYKQFRDLKLLVTAS	0.0
7:98562388-98562388 A>C	1.0	4196	COLORECTAL	-	-	-	1	TRRAP	NM_003496,p.E2297D|uc003upp.3,p.E2315D|uc003upr.3,p.E2014D|ENST00000355540,p.E2297D|uc011kis.2,p.E2297D|ENST00000359863,p.E2315D|NM_001244580,p.E2315D	retained_intron, protein_coding	uc011kis.2	nonsynonymous SNV	exon46	c.A6891C	p.E2297D	EHLNPQAASGSTEATSGTSELVMLS	EHLNPQAASGSTDATSGTSELVMLS	8.0	3.0	-	-	4196_7:98562388-98562388 A>C_EHLNPQAASGSTDATSGTSELVMLS	0.0
3:52325070-52325070 A>T	1.0	3919	MELANOMA	-	-	-	-	GLYCTK	NM_145262,p.I158F|ENST00000477382,p.I158F|ENST00000471180,p.I31F|ENST00000461183,p.I74F|uc003ddo.3,p.I158F|ENST00000354773,p.I158F|uc003ddq.2,p.I158F|ENST00000486393,p.I158F|ENST00000473032,p.I158F|uc003ddp.1,p.I158F|ENST00000305690,p.I158F|NM_001144951,p.I158F|ENST00000436784,p.I158F	retained_intron, protein_coding, nonsense_mediated_decay	uc003ddq.2	nonsynonymous SNV	exon3	c.A472T	p.I158F	LPDRDALRAALAIQQLAEGLTADDL	LPDRDALRAALAFQQLAEGLTADDL	5.0	3.0	-	-	3919_3:52325070-52325070 A>T_LPDRDALRAALAFQQLAEGLTADDL	0.0
8:139164248-139164248 C>T	0.0	4155	MELANOMA	-	-	-	2	FAM135B	uc003yva.3,p.G386R|ENST00000395297,p.G824R|uc003yvb.3,p.G386R|uc003yuy.3,p.G824R|ENST00000467365,p.G134R|NM_015912,p.G824R|uc003yux.3,p.G725R|ENST00000276737,p.G824R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003yvb.3	nonsynonymous SNV	exon1	c.G1156A	p.G386R	CSQLCGDSGTDAGADHPLVEIVLDA	CSQLCGDSGTDARADHPLVEIVLDA	3.0	10.0	-	-	4155_8:139164248-139164248 C>T_CSQLCGDSGTDARADHPLVEIVLDA	0.0
22:50278118-50278118 T>G	1.0	4071	COLORECTAL	-	-	-	-	ZBED4	NM_014838,p.L270V|ENST00000216268,p.L270V|uc003bix.2,p.L270V|uc021wrx.1,p.L270V	protein_coding	uc021wrx.1	nonsynonymous SNV	exon1	c.T808G	p.L270V	LPALHYDEPAENLAEKSLPLPKSTS	LPALHYDEPAENVAEKSLPLPKSTS	8.0	6.0	-	-	4071_22:50278118-50278118 T>G_LPALHYDEPAENVAEKSLPLPKSTS	0.0
3:14712469-14712469 C>T	1.0	3713	MELANOMA	-	-	-	-	CCDC174	uc010hej.3,p.A220V|ENST00000303688,p.A315V|ENST00000383794,p.A391V|uc003byw.3,p.A391V|NM_016474,p.A391V	retained_intron, protein_coding, processed_transcript	uc010hej.3	nonsynonymous SNV	exon6	c.C659T	p.A220V	QSDLRAERDPEFAPPSDYFVGQKRT	QSDLRAERDPEFVPPSDYFVGQKRT	6.0	10.0	-	-	3713_3:14712469-14712469 C>T_QSDLRAERDPEFVPPSDYFVGQKRT	0.0
6:90440633-90440633 G>A	1.0	3713	MELANOMA	-	-	-	-	MDN1	uc003pnn.1,p.S1651F|ENST00000369393,p.S1651F|ENST00000428876,p.S1651F|NM_014611,p.S1651F	protein_coding, processed_transcript, nonsense_mediated_decay	uc003pnn.1	nonsynonymous SNV	exon35	c.C4952T	p.S1651F	LVYIDGIGSGVTSSGFGTALLARKE	LVYIDGIGSGVTFSGFGTALLARKE	6.0	9.0	-	-	3713_6:90440633-90440633 G>A_LVYIDGIGSGVTFSGFGTALLARKE	0.0
11:6422902-6422902 C>G	1.0	4252	COLORECTAL	-	-	-	-	APBB1	NM_001257323,p.A247P|ENST00000311051,p.A467P|ENST00000533407,p.A208P|uc031pyu.1,p.A467P|ENST00000530885,p.A247P|uc001mdc.1,p.A467P|uc001mdd.4,p.A247P|NM_145689,p.A467P|ENST00000299402,p.A467P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pyu.1	nonsynonymous SNV	exon9	c.G1399C	p.A467P	VGRDSGRDFAYVARDKLTQMLKCHV	VGRDSGRDFAYVPRDKLTQMLKCHV	8.0	7.0	-	-	4252_11:6422902-6422902 C>G_VGRDSGRDFAYVPRDKLTQMLKCHV	0.0
1:64624848-64624848 G>A	1.0	4237	NSCLC	-	-	-	-	ROR1	uc001dbj.3,p.M453I|NM_005012,p.M453I|ENST00000371079,p.M453I	protein_coding, processed_transcript	uc001dbj.3	nonsynonymous SNV	exon8	c.G1359A	p.M453I	RQPKHVRGQNVEMSMLNAYKPKSKA	RQPKHVRGQNVEISMLNAYKPKSKA	7.0	7.0	-	-	4237_1:64624848-64624848 G>A_RQPKHVRGQNVEISMLNAYKPKSKA	0.0
19:2117225-2117225 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM3937962,COSM3937961,COSM3937963;OCCURENCE=1(oesophagus)	-	AP3D1	ENST00000356926,p.E528K|uc031riw.1,p.E347K|ENST00000355272,p.E619K|NM_003938,p.E619K|uc002luz.4,p.E619K|ENST00000350812,p.E450K|ENST00000345016,p.E619K|uc002lva.4,p.E619K|NM_001261826,p.E619K	retained_intron, protein_coding, processed_transcript	uc031riw.1	nonsynonymous SNV	exon9	c.G1039A	p.E347K	VAPKAQKKVPVPEGLDLDAWINEPL	VAPKAQKKVPVPKGLDLDAWINEPL	9.0	7.0	-	-	4196_19:2117225-2117225 C>T_VAPKAQKKVPVPKGLDLDAWINEPL	0.0
12:57501995-57501995 G>A	1.0	3713	MELANOMA	-	-	-	1	STAT6	ENST00000553275,p.P23S|uc009zpg.3,p.P72S|NM_001178079,p.P23S|NM_001178078,p.P23S|ENST00000554825,p.P23S|ENST00000543873,p.P23S|uc001sna.3,p.P23S|uc009zpf.3,p.P23S|ENST00000300134,p.P23S|ENST00000454075,p.P23S|ENST00000554663,p.P23S|ENST00000554764,p.P23S|ENST00000553397,p.P23S|ENST00000556155,p.P23S|ENST00000556259,p.P23S|ENST00000555849,p.P23S|uc009zpe.3,p.P23S|ENST00000553499,p.P23S|ENST00000555104,p.P23S|NM_003153,p.P23S|ENST00000557635,p.P23S	retained_intron, protein_coding, nonsense_mediated_decay	uc009zpg.3	nonsynonymous SNV	exon2	c.C214T	p.P72S	PPEKVQRLYVDFPQHLRHLLGDWLE	PPEKVQRLYVDFSQHLRHLLGDWLE	10.0	4.0	-	-	3713_12:57501995-57501995 G>A_PPEKVQRLYVDFSQHLRHLLGDWLE	0.0
7:50468243-50468243 A>G	0.0	4110	BILE DUCT	-	-	-	1	IKZF1	uc003toy.4,p.N451S|NM_001291837,p.N451S|ENST00000349824,p.N350S|NM_006060,p.N493S|NM_001220768,p.N406S|NM_001291839,p.N364S|ENST00000346667,p.N263S|uc022acy.1,p.N300S|NM_001291840,p.N263S|ENST00000331340,p.N493S|ENST00000357364,p.N406S|NM_001291838,p.N406S|uc011kck.2,p.N406S|NM_001220770,p.N354S|NM_001291842,p.N340S|uc022acw.1,p.N364S|uc003toz.4,p.N463S|uc022act.1,p.N396S|uc022acr.1,p.N268S|ENST00000438033,p.N406S|NM_001220771,p.N350S|NM_001220767,p.N396S|ENST00000359197,p.N451S|uc022acu.1,p.N406S|NM_001291844,p.N298S|ENST00000439701,p.N451S|uc022acz.1,p.N310S|uc003tpa.4,p.N258S|uc022acq.1,p.N350S|uc010kyx.3,p.N233S|uc022acs.1,p.N223S|uc022acx.1,p.N406S|ENST00000343574,p.N406S|NM_001291843,p.N308S|uc003tox.4,p.N451S|NM_001291841,p.N350S|uc022acv.1,p.N354S|NM_001220765,p.N451S|uc003tow.4,p.N493S	retained_intron, protein_coding, processed_transcript	uc022acz.1	nonsynonymous SNV	exon5	c.A929G	p.N310S	MGCHGFRDPFECNMCGYHSQDRYEF	MGCHGFRDPFECSMCGYHSQDRYEF	4.0	10.0	-	-	4110_7:50468243-50468243 A>G_MGCHGFRDPFECSMCGYHSQDRYEF	0.0
9:70900911-70900911 ->A	0.0	4237	NSCLC	-	-	ID=COSM1462702;OCCURENCE=3(large_intestine)	-	CBWD3	uc004agl.4,p.Q61fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc004agl.4	frameshift insertion	exon5	c.184dupA	p.Q61fs	LGQILETQRSSLQKKLQHVPGTQPH	LGQILETQRSSLQKKTSACARNTTSP	8.0	10.0	-	-	4237_9:70900911-70900911 ->A_LGQILETQRSSLQKKTSACARNTTSP	0.0
15:63967021-63967021 T>A	1.0	4071	COLORECTAL	-	-	-	-	HERC1	ENST00000443617,p.S2456C|NM_003922,p.S2456C|uc002amp.3,p.S2456C	retained_intron, protein_coding, nonsense_mediated_decay	uc002amp.3	nonsynonymous SNV	exon38	c.A7366T	p.S2456C	LTSDDVKSQSTTSSKSENEIASFSL	LTSDDVKSQSTTCSKSENEIASFSL	9.0	9.0	-	-	4071_15:63967021-63967021 T>A_LTSDDVKSQSTTCSKSENEIASFSL	0.0
7:100551602-100551602 C>T	0.0	3903	MELANOMA	-	-	ID=COSM1722922,COSM1722921;OCCURENCE=2(NS)	-	MUC3A	uc003uxl.1,p.S18F|ENST00000319509,p.S118F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uxl.1	nonsynonymous SNV	exon1	c.C53T	p.S18F	MTLRITENTPISSFSTSIVVIPETP	MTLRITENTPISFFSTSIVVIPETP	3.0	1.0	-	-	3903_7:100551602-100551602 C>T_MTLRITENTPISFFSTSIVVIPETP	0.0
8:82615095-82615095 T>A	1.0	3678	MELANOMA	-	-	-	-	ZFAND1	uc010lzx.2,p.L207F|NM_024699,p.L214F|uc003yck.2,p.L107F|ENST00000520635,p.L107F|uc022awu.1,p.L107F|uc003ycj.2,p.L214F|ENST00000522520,p.L107F|ENST00000521287,p.L107F|NM_001170796,p.L207F|ENST00000523096,p.L207F|ENST00000220669,p.L214F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022awu.1	nonsynonymous SNV	exon7	c.A321T	p.L107F	LKNDNNKFTAKKLRLCHITSGEALP	LKNDNNKFTAKKFRLCHITSGEALP	10.0	5.0	-	-	3678_8:82615095-82615095 T>A_LKNDNNKFTAKKFRLCHITSGEALP	0.0
7:138864373-138864373 C>A	1.0	4298	COLORECTAL	-	-	-	-	TTC26	ENST00000430935,p.S432R|NM_001144920,p.S432R|ENST00000464848,p.S432R|ENST00000495038,p.S301R|NM_001287512,p.S301R|uc011kqo.1,p.S401R|uc011kqq.1,p.S301R|uc011kqp.1,p.S327R|uc003vus.2,p.S432R|uc003vut.2,p.S292R|NM_001144923,p.S401R|ENST00000343187,p.S401R|ENST00000478836,p.S325R|uc011kqn.1,p.S432R|NM_024926,p.S432R|NM_001287513,p.S327R	protein_coding, processed_transcript, nonsense_mediated_decay	uc011kqq.1	nonsynonymous SNV	exon12	c.C903A	p.S301R	QSEKMKNDYIYLSWLARCYIMNKKP	QSEKMKNDYIYLRWLARCYIMNKKP	5.0	4.0	-	-	4298_7:138864373-138864373 C>A_QSEKMKNDYIYLRWLARCYIMNKKP	0.0
5:140711926-140711926 G>A	0.0	4298	COLORECTAL	-	-	ID=COSM1062929,COSM1062928;OCCURENCE=1(endometrium)	-	PCDHGA1	ENST00000378105,p.A559T|NM_018912,p.A559T|uc003lji.2,p.A559T|NM_031993,p.A559T|ENST00000517417,p.A559T|uc011dan.2,p.A559T	protein_coding	uc011dan.2	nonsynonymous SNV	exon1	c.G1675A	p.A559T	SLSLFLLDQNDNAPEILYPALPTDG	SLSLFLLDQNDNTPEILYPALPTDG	5.0	3.0	-	-	4298_5:140711926-140711926 G>A_SLSLFLLDQNDNTPEILYPALPTDG	0.0
20:20349762-20349762 A>T	0.0	4252	COLORECTAL	-	-	-	-	INSM1	ENST00000310227,p.Q284L|NM_002196,p.Q284L|uc002wrx.3,p.Q284L	protein_coding	uc002wrx.3	nonsynonymous SNV	exon1	c.A851T	p.Q284L	CKEEYADPFALAQHKCSRIVRVEYR	CKEEYADPFALALHKCSRIVRVEYR	3.0	7.0	CD8	-	4252_20:20349762-20349762 A>T_CKEEYADPFALALHKCSRIVRVEYR	2.0
19:31769447-31769447 C>T	0.0	4335	COLORECTAL	-	-	ID=COSM286028,COSM286029;OCCURENCE=1(large_intestine)	-	TSHZ3	uc002nsy.4,p.A418T|NM_020856,p.A418T|ENST00000240587,p.A418T	protein_coding, processed_transcript	uc002nsy.4	nonsynonymous SNV	exon2	c.G1252A	p.A418T	MVTGHFIKVTNSAMKKGKPIVETPV	MVTGHFIKVTNSTMKKGKPIVETPV	5.0	8.0	-	-	4335_19:31769447-31769447 C>T_MVTGHFIKVTNSTMKKGKPIVETPV	0.0
5:139941760-139941760 G>A	0.0	4189	MELANOMA	-	-	-	-	APBB3	NM_133172,p.P184L|NM_133173,p.P184L|ENST00000511896,p.P138L|ENST00000412920,p.P184L|ENST00000358580,p.P184L|uc021yeg.1,p.P184L|ENST00000467078,p.P184L|ENST00000357560,p.P184L|uc003lgd.1,p.P184L|uc003lge.1,p.P184L|NM_133174,p.P184L|ENST00000511201,p.P184L|ENST00000356738,p.P184L|uc021yeh.1,p.P184L|ENST00000354402,p.P184L|NM_006051,p.P184L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021yeh.1	nonsynonymous SNV	exon6	c.C551T	p.P184L	MILKKDAMSLVNPLDHSLIHCQPLV	MILKKDAMSLVNLLDHSLIHCQPLV	6.0	10.0	-	-	4189_5:139941760-139941760 G>A_MILKKDAMSLVNLLDHSLIHCQPLV	0.0
2:96048197-96048197 G>A	0.0	4158	COLORECTAL	-	-	-	-	KCNIP3	uc002sup.3,p.A210T|NM_013434,p.A210T|NM_001034914,p.A184T|ENST00000360990,p.A188T|ENST00000468529,p.A184T|uc002suq.3,p.A184T|ENST00000295225,p.A210T	retained_intron, protein_coding, processed_transcript	uc002suq.3	nonsynonymous SNV	exon6	c.G550A	p.A184T	MGRHTYPILREDAPAEHVERFFEKM	MGRHTYPILREDTPAEHVERFFEKM	3.0	4.0	-	-	4158_2:96048197-96048197 G>A_MGRHTYPILREDTPAEHVERFFEKM	0.0
5:90008213-90008213 C>T	0.0	4301	MELANOMA	-	-	-	-	GPR98	NM_032119,p.S3051F|uc003kju.3,p.S3051F|uc003kjv.3,p.S651F|ENST00000405460,p.S3051F	retained_intron, protein_coding, processed_transcript	uc003kjv.3	nonsynonymous SNV	exon10	c.C1952T	p.S651F	GDEKFQLILTNPSPGLELGKNTIAL	GDEKFQLILTNPFPGLELGKNTIAL	2.0	2.0	-	-	4301_5:90008213-90008213 C>T_GDEKFQLILTNPFPGLELGKNTIAL	0.0
17:7365345-7365345 G>A	1.0	4155	MELANOMA	-	-	-	-	ZBTB4	NM_020899,p.P986S|ENST00000380599,p.P986S|uc002ghd.4,p.P986S|uc002ghc.4,p.P986S|NM_001128833,p.P986S|ENST00000311403,p.P986S	protein_coding	uc002ghd.4	nonsynonymous SNV	exon4	c.C2956T	p.P986S	PQAAPPAPPTPPPPTLPPPIPPKGE	PQAAPPAPPTPPSPTLPPPIPPKGE	8.0	8.0	-	-	4155_17:7365345-7365345 G>A_PQAAPPAPPTPPSPTLPPPIPPKGE	0.0
6:16326840-16326840 G>A	1.0	2556	MELANOMA	-	-	-	-	ATXN1	ENST00000244769,p.P568S|NM_000332,p.P568S|NM_001128164,p.P568S|uc003nbt.3,p.P568S|ENST00000436367,p.P568S|uc010jpi.3,p.P568S	protein_coding, processed_transcript	uc010jpi.3	nonsynonymous SNV	exon7	c.C1702T	p.P568S	VVQSVASPAAAPPTLPPYFMKGSII	VVQSVASPAAAPSTLPPYFMKGSII	8.0	3.0	-	-	2556_6:16326840-16326840 G>A_VVQSVASPAAAPSTLPPYFMKGSII	0.0
17:3746391-3746391 ->A	0.0	4284	COLORECTAL	-	-	-	-	C17orf85	NM_001114118,p.V80fs|uc010ckl.2,p.V80fs|ENST00000389005,p.V80fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ckl.2	frameshift insertion	exon2	c.237dupT	p.V80fs	ENKAGSFITGIDVTSKEAIEKKEQR	ENKAGSFITGIDCHLQGSN	9.0	8.0	-	-	4284_17:3746391-3746391 ->A_ENKAGSFITGIDCHLQGSN	0.0
5:148930448-148930448 G>A	1.0	2098	MELANOMA	-	-	-	-	CSNK1A1	uc003lqx.2,p.S27F|NM_001892,p.S27F|ENST00000515768,p.S27F|ENST00000515748,p.S27F|ENST00000377843,p.S27F|ENST00000523203,p.S27F|uc003lqy.2,p.S27F|NM_001025105,p.S27F|uc010jha.2,p.S27F|ENST00000261798,p.S27F|uc003lqw.2,p.S27F|NM_001271741,p.S27F	protein_coding, nonsense_mediated_decay	uc010jha.2	nonsynonymous SNV	exon1	c.C80T	p.S27F	GKYKLVRKIGSGSFGDIYLAINITN	GKYKLVRKIGSGLFGDIYLAINITN	10.0	9.0	CD8	dnv, p.S27F>p.S27L PR	2098_5:148930448-148930448 G>A_GKYKLVRKIGSGLFGDIYLAINITN	1.0
17:48594717-48594717 C>T	0.0	4238	COLORECTAL	0.0005	-	-	-	MYCBPAP	uc010wmr.2,p.R133C|ENST00000452039,p.R133C|ENST00000436259,p.R96C|NM_032133,p.R133C|ENST00000323776,p.R133C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wmr.2	nonsynonymous SNV	exon3	c.C397T	p.R133C	EDKRVITQKFIIRKLKPMDPRRKVC	EDKRVITQKFIICKLKPMDPRRKVC	4.0	6.0	-	-	4238_17:48594717-48594717 C>T_EDKRVITQKFIICKLKPMDPRRKVC	0.0
X:23411490-23411490 A>G	0.0	4158	COLORECTAL	-	-	-	-	PTCHD1	ENST00000379361,p.K619E|uc004dal.4,p.K619E|NM_173495,p.K619E	protein_coding	uc004dal.4	nonsynonymous SNV	exon3	c.A1855G	p.K619E	KNFTDMLRNSFLKAPQFSHFQEDII	KNFTDMLRNSFLEAPQFSHFQEDII	5.0	8.0	-	-	4158_X:23411490-23411490 A>G_KNFTDMLRNSFLEAPQFSHFQEDII	0.0
17:42290243-42290243 G>A	1.0	3903	MELANOMA	-	-	-	-	UBTF	NM_014233,p.P202S|ENST00000393606,p.P202S|NM_001076684,p.P202S|ENST00000529383,p.P202S|ENST00000343638,p.P202S|uc010czs.3,p.P202S|ENST00000527034,p.P202S|uc002ige.2,p.P202S|uc002igc.3,p.P202S|NM_001076683,p.P202S|ENST00000526094,p.P202S|ENST00000302904,p.P202S|uc002igd.3,p.P202S|uc010czt.3,p.P202S|ENST00000533177,p.P202S|ENST00000436088,p.P202S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010czt.3	nonsynonymous SNV	exon7	c.C604T	p.P202S	AKKSDIPEKPKTPQQLWYTHEKKVY	AKKSDIPEKPKTSQQLWYTHEKKVY	9.0	5.0	-	-	3903_17:42290243-42290243 G>A_AKKSDIPEKPKTSQQLWYTHEKKVY	0.0
3:170928935-170928935 C>G	0.0	3775	CERVICAL	-	-	-	-	TNIK	NM_001161562,p.K92N|uc003fhj.2,p.K92N|ENST00000488470,p.K92N|ENST00000436636,p.K92N|uc003fhi.2,p.K92N|NM_001161564,p.K92N|uc003fhk.2,p.K92N|ENST00000538048,p.K92N|uc003fhn.2,p.K92N|ENST00000284483,p.K92N|ENST00000475336,p.K92N|uc003fho.2,p.K92N|ENST00000357327,p.K92N|NM_001161565,p.K92N|uc003fhm.2,p.K92N|NM_015028,p.K92N|uc003fhl.2,p.K92N|NM_001161566,p.K92N|ENST00000470834,p.K92N|ENST00000369326,p.K92N|ENST00000468757,p.K66N|uc003fhh.2,p.K92N|ENST00000341852,p.K92N|NM_001161560,p.K92N|ENST00000460047,p.K92N|NM_001161561,p.K92N|NM_001161563,p.K92N	retained_intron, protein_coding, processed_transcript	uc003fho.2	nonsynonymous SNV	exon4	c.G276C	p.K92N	RNIATYYGAFIKKNPPGMDDQLWLV	RNIATYYGAFIKNNPPGMDDQLWLV	5.0	5.0	-	-	3775_3:170928935-170928935 C>G_RNIATYYGAFIKNNPPGMDDQLWLV	0.0
8:80831334-80831334 G>A	1.0	4071	COLORECTAL	-	-	-	-	MRPS28	ENST00000276585,p.L149F|ENST00000520946,p.L87F|uc003ybp.3,p.L149F|NM_014018,p.L149F|ENST00000519120,p.L67F|ENST00000521434,p.L87F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ybp.3	nonsynonymous SNV	exon3	c.C445T	p.L149F	GTRVRLRLLDLELTSRFLGATTDTT	GTRVRLRLLDLEFTSRFLGATTDTT	8.0	10.0	CD8	-	4071_8:80831334-80831334 G>A_GTRVRLRLLDLEFTSRFLGATTDTT	2.0
17:46627893-46627902 CGGCAGGGGG>-	1.0	4266	COLORECTAL	-	-	-	-	HOXB3	uc002inn.3,p.P364fs|ENST00000460160,p.P232fs|ENST00000470495,p.P364fs|ENST00000489475,p.P291fs|ENST00000498678,p.P364fs|ENST00000490677,p.P230fs|ENST00000485909,p.P232fs|ENST00000311626,p.P364fs|uc002ino.3,p.P364fs|uc010dbg.3,p.P364fs|uc010wlk.2,p.P232fs|uc010wlm.2,p.P291fs|NM_002146,p.P364fs|ENST00000472863,p.P291fs|ENST00000476342,p.P364fs|uc010wll.2,p.P291fs|uc010dbf.3,p.P364fs	retained_intron, protein_coding, processed_transcript	uc010wlm.2	frameshift deletion	exon4	c.871_880del	p.P291fs	YVGGGGYADPLPPPAGPSLYGLNHL	YVGGGGYADPLPAPPSMASTTFPITLPGTWTTTGRPLWRPASTTDPANPTPPTQTSPLTTRLLLRVESKKRPN	8.0	5.0	-	-	4266_17:46627893-46627902 CGGCAGGGGG>-_YVGGGGYADPLPAPPSMASTTFPITLPGTWTTTGRPLWRPASTTDPANPTPPTQTSPLTTRLLLRVESKKRPN	0.0
3:195047682-195047682 G>C	1.0	4346	COLORECTAL	-	-	-	-	ACAP2	ENST00000326793,p.R226G|NM_012287,p.R226G|uc003fun.4,p.R226G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003fun.4	nonsynonymous SNV	exon9	c.C676G	p.R226G	GPYMKDLGAQLDRLVVDAAKEKREM	GPYMKDLGAQLDGLVVDAAKEKREM	9.0	8.0	-	-	4346_3:195047682-195047682 G>C_GPYMKDLGAQLDGLVVDAAKEKREM	0.0
15:87089288-87089288 G>A	0.0	4298	COLORECTAL	-	-	-	-	AGBL1	NM_152336,p.C868Y|ENST00000441037,p.C868Y|ENST00000421325,p.C868Y|uc002blz.1,p.C868Y|ENST00000389298,p.C599Y	retained_intron, protein_coding	uc002blz.1	nonsynonymous SNV	exon19	c.G2603A	p.C868Y	GHSQKKNVFLYGCSIKETLWQAACT	GHSQKKNVFLYGYSIKETLWQAACT	5.0	1.0	-	-	4298_15:87089288-87089288 G>A_GHSQKKNVFLYGYSIKETLWQAACT	0.0
19:20003351-20003351 C>T	1.0	3919	MELANOMA	-	-	-	-	ZNF253	NM_021047,p.S432F|ENST00000589717,p.S432F|ENST00000355650,p.S356F|uc002nok.3,p.S356F|uc002noj.3,p.S432F	retained_intron, protein_coding	uc002nok.3	nonsynonymous SNV	exon2	c.C1067T	p.S356F	GEKPYKCEECGKSFTASSTLTTHKR	GEKPYKCEECGKFFTASSTLTTHKR	3.0	8.0	-	-	3919_19:20003351-20003351 C>T_GEKPYKCEECGKFFTASSTLTTHKR	0.0
1:153984763-153984763 G>T	0.0	4110	BILE DUCT	-	-	-	-	NUP210L	uc009woq.3,p.F488L|uc010peh.2,p.F1579L|NM_001159484,p.F1579L|uc001fdw.3,p.F1579L|ENST00000368559,p.F1579L|ENST00000271854,p.F1579L|NM_207308,p.F1579L|ENST00000368553,p.F512L	protein_coding	uc010peh.2	nonsynonymous SNV	exon34	c.C4737A	p.F1579L	KTYLTNTLNSTVFKLFITTGRNGVN	KTYLTNTLNSTVLKLFITTGRNGVN	1.0	8.0	-	-	4110_1:153984763-153984763 G>T_KTYLTNTLNSTVLKLFITTGRNGVN	0.0
19:10431550-10431550 C>T	0.0	4158	COLORECTAL	-	-	-	-	RAVER1	ENST00000593136,p.G92S	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000593136	nonsynonymous SNV	exon4	c.G274A	p.G92S	PESLPEPTQPAPGQQPGGPWRWQQQ	PESLPEPTQPAPSQQPGGPWRWQQQ	5.0	5.0	-	-	4158_19:10431550-10431550 C>T_PESLPEPTQPAPSQQPGGPWRWQQQ	0.0
X:153580369-153580369 G>A	1.0	4281	COLORECTAL	-	-	-	2	FLNA	uc011mzn.1,p.R397W|ENST00000369850,p.R2264W|ENST00000344736,p.R2224W|ENST00000360319,p.R2256W|ENST00000444578,p.R204W|ENST00000369856,p.R397W|NM_001110556,p.R2264W|uc004fkk.2,p.R2264W|uc010nuu.1,p.R2256W|ENST00000422373,p.R2256W|NM_001456,p.R2256W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mzn.1	nonsynonymous SNV	exon13	c.C1189T	p.R397W	EAGVPAEFSIWTREAGAGGLAIAVE	EAGVPAEFSIWTWEAGAGGLAIAVE	10.0	10.0	CD8	-	4281_X:153580369-153580369 G>A_EAGVPAEFSIWTWEAGAGGLAIAVE	2.0
11:10585760-10585760 C>T	0.0	3795	MELANOMA	-	-	-	-	LYVE1	uc001miv.2,p.E83K|ENST00000256178,p.E83K|NM_006691,p.E83K	protein_coding, processed_transcript, nonsense_mediated_decay	uc001miv.2	nonsynonymous SNV	exon2	c.G247A	p.E83K	KDQVETALKASFETCSYGWVGDGFV	KDQVETALKASFKTCSYGWVGDGFV	7.0	10.0	-	-	3795_11:10585760-10585760 C>T_KDQVETALKASFKTCSYGWVGDGFV	0.0
8:133790126-133790126 C>T	1.0	2369	MELANOMA	-	-	-	-	PHF20L1	uc011lja.2,p.R18C|ENST00000315808,p.R18C|ENST00000395386,p.R18C|uc003ytr.3,p.R18C|uc003ytt.3,p.R18C|NM_016018,p.R18C|NM_198513,p.R18C|ENST00000486199,p.R18C|ENST00000395383,p.R18C|uc010mdv.3,p.R18C|NM_001277196,p.R18C|ENST00000395390,p.R18C|ENST00000361997,p.R18C|ENST00000337920,p.R18C|ENST00000395379,p.R18C|ENST00000395376,p.R18C	retained_intron, protein_coding, nonsense_mediated_decay	uc011lja.2	nonsynonymous SNV	exon2	c.C52T	p.R18C	PNRPGITFEIGARLEALDYLQKWYP	PNRPGITFEIGACLEALDYLQKWYP	8.0	7.0	-	-	2369_8:133790126-133790126 C>T_PNRPGITFEIGACLEALDYLQKWYP	0.0
7:107423453-107423453 A>C	1.0	4196	COLORECTAL	-	-	-	-	SLC26A3	uc003ves.2,p.V367G|ENST00000340010,p.V402G|ENST00000422236,p.V367G|uc003ver.2,p.V402G|NM_000111,p.V402G	retained_intron, protein_coding, nonsense_mediated_decay	uc003ves.2	nonsynonymous SNV	exon10	c.T1100G	p.V367G	GFAGSTALSRSAVQESTGGKTQIAG	GFAGSTALSRSAGQESTGGKTQIAG	10.0	3.0	-	-	4196_7:107423453-107423453 A>C_GFAGSTALSRSAGQESTGGKTQIAG	0.0
17:7339684-7339684 A>G	1.0	4126	NSCLC	-	-	-	-	TMEM102	ENST00000396568,p.D129G|uc002ggy.2,p.D129G|uc002ggx.1,p.D129G|ENST00000323206,p.D129G|NM_178518,p.D129G	protein_coding	uc002ggy.2	nonsynonymous SNV	exon2	c.A386G	p.D129G	AGFTLLVPMFSLDGTELQLDLESCY	AGFTLLVPMFSLGGTELQLDLESCY	6.0	4.0	-	-	4126_17:7339684-7339684 A>G_AGFTLLVPMFSLGGTELQLDLESCY	0.0
4:189060944-189060944 G>A	0.0	4081	COLORECTAL	-	-	ID=COSM209201;OCCURENCE=1(large_intestine)	-	TRIML1	ENST00000332517,p.A78T|NM_178556,p.A78T|uc003izm.1,p.A78T	protein_coding, processed_transcript	uc003izm.1	nonsynonymous SNV	exon1	c.G232A	p.A78T	QSNERLGRLASIARQLRSQVLQSED	QSNERLGRLASITRQLRSQVLQSED	1.0	10.0	-	-	4081_4:189060944-189060944 G>A_QSNERLGRLASITRQLRSQVLQSED	0.0
13:107164973-107164973 G>C	1.0	4245	COLORECTAL	-	-	-	-	EFNB2	uc001vqi.3,p.P104A|NM_004093,p.P104A|ENST00000245323,p.P104A	protein_coding	uc001vqi.3	nonsynonymous SNV	exon2	c.C310G	p.P104A	KKENTPLLNCAKPDQDIKFTIKFQE	KKENTPLLNCAKADQDIKFTIKFQE	9.0	1.0	-	-	4245_13:107164973-107164973 G>C_KKENTPLLNCAKADQDIKFTIKFQE	0.0
1:40536183-40536183 A>G	1.0	4180	BREAST	-	-	-	-	CAP1	ENST00000340450,p.Q399R|uc001cey.4,p.Q400R|NM_001105530,p.Q400R|ENST00000372805,p.Q400R|uc001cez.4,p.Q400R|NM_006367,p.Q400R|uc010oje.2,p.Q317R|ENST00000372792,p.Q400R|uc001cfa.4,p.Q400R|ENST00000372798,p.Q399R|ENST00000372802,p.Q399R|uc009vvz.3,p.Q400R|ENST00000372797,p.Q400R	protein_coding, processed_transcript	uc010oje.2	nonsynonymous SNV	exon10	c.A950G	p.Q317R	IVEIINSKDVKVQVMGKVPTISINK	IVEIINSKDVKVRVMGKVPTISINK	10.0	8.0	CD8	-	4180_1:40536183-40536183 A>G_IVEIINSKDVKVRVMGKVPTISINK	2.0
X:100747655-100747655 C>T	0.0	4189	MELANOMA	-	-	-	-	ARMCX4	uc031tkd.1,p.A1360V|NM_001256155,p.A1360V|ENST00000423738,p.A1360V|uc031tkc.1,p.A1360V	protein_coding, processed_transcript, nonsense_mediated_decay	uc031tkd.1	nonsynonymous SNV	exon1	c.C4079T	p.A1360V	SSGRSWADTADQASGGSRLGHVDQS	SSGRSWADTADQVSGGSRLGHVDQS	5.0	10.0	-	-	4189_X:100747655-100747655 C>T_SSGRSWADTADQVSGGSRLGHVDQS	0.0
20:61527623-61527623 G>A	1.0	3466	MELANOMA	-	-	ID=COSM1028986;OCCURENCE=1(endometrium)	-	DIDO1	NM_033081,p.R726C|NM_001193369,p.R726C|NM_080797,p.R726C|uc002yds.2,p.R726C|ENST00000395340,p.R726C|ENST00000266070,p.R726C|NM_001193370,p.R726C|ENST00000395343,p.R726C|uc002ydr.2,p.R726C|uc002ydt.2,p.R726C|uc002ydu.2,p.R726C|ENST00000395335,p.R726C	protein_coding	uc002ydu.2	nonsynonymous SNV	exon8	c.C2176T	p.R726C	FQVTDNRYKSKYRSIMFNLKDPKNQ	FQVTDNRYKSKYCSIMFNLKDPKNQ	9.0	6.0	-	-	3466_20:61527623-61527623 G>A_FQVTDNRYKSKYCSIMFNLKDPKNQ	0.0
13:103389769-103389769 C>A	0.0	4129	NSCLC	-	-	-	-	CCDC168	NM_001146197,p.Q4426H|uc001vpm.3,p.Q4426H	protein_coding	uc001vpm.3	nonsynonymous SNV	exon4	c.G13278T	p.Q4426H	TEQEKRDGHKSKQETVLFLHLPSES	TEQEKRDGHKSKHETVLFLHLPSES	1.0	7.0	-	-	4129_13:103389769-103389769 C>A_TEQEKRDGHKSKHETVLFLHLPSES	0.0
11:18308193-18308193 C>T	1.0	4240	BREAST	-	-	-	-	HPS5	ENST00000438420,p.V814M|ENST00000349215,p.V928M|NM_181508,p.V814M|uc001moe.1,p.V814M|uc001mod.1,p.V928M|NM_007216,p.V814M|ENST00000544218,p.V114M|ENST00000537258,p.V35M|ENST00000396253,p.V814M|NM_181507,p.V928M|uc001mof.1,p.V814M	retained_intron, protein_coding, processed_transcript	uc001mof.1	nonsynonymous SNV	exon18	c.G2440A	p.V814M	PESLRLDWLLLAVSLDAPPSTSTMD	PESLRLDWLLLAMSLDAPPSTSTMD	7.0	9.0	-	-	4240_11:18308193-18308193 C>T_PESLRLDWLLLAMSLDAPPSTSTMD	0.0
11:3128545-3128545 G>A	1.0	4078	GASTRIC	-	-	-	-	OSBPL5	NM_145638,p.P268L|NM_020896,p.P336L|uc009ydw.2,p.P268L|ENST00000348039,p.P268L|uc009ydx.3,p.P360L|uc001lxk.2,p.P336L|uc010qxq.1,p.P247L|NM_001144063,p.P268L|ENST00000389989,p.P268L|uc001lxl.2,p.P268L|ENST00000263650,p.P336L|ENST00000525498,p.P247L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qxq.1	nonsynonymous SNV	exon7	c.C740T	p.P247L	ESGSDQSETPGAPVRRGTTYVEQVQ	ESGSDQSETPGALVRRGTTYVEQVQ	9.0	9.0	-	-	4078_11:3128545-3128545 G>A_ESGSDQSETPGALVRRGTTYVEQVQ	0.0
2:100194858-100194858 G>A	0.0	4081	COLORECTAL	-	-	ID=COSM2979630;OCCURENCE=1(large_intestine)	1	AFF3	NM_001025108,p.T975M|ENST00000409236,p.T950M|uc002tag.3,p.T950M|NM_002285,p.T950M|ENST00000317233,p.T950M|ENST00000409579,p.T975M|ENST00000356421,p.T975M|uc002taf.3,p.T975M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tag.3	nonsynonymous SNV	exon17	c.C2849T	p.T950M	SENIPLHKSRPQTKPWSPGSNGHRD	SENIPLHKSRPQMKPWSPGSNGHRD	3.0	5.0	-	-	4081_2:100194858-100194858 G>A_SENIPLHKSRPQMKPWSPGSNGHRD	0.0
17:3567983-3567983 T>G	1.0	4298	COLORECTAL	-	-	-	-	TAX1BP3	ENST00000225525,p.K50T|uc002fwc.3,p.K50T|NM_014604,p.K50T	protein_coding	uc002fwc.3	nonsynonymous SNV	exon2	c.A149C	p.K50T	DQDPSQNPFSEDKTDKGIYVTRVSE	DQDPSQNPFSEDTTDKGIYVTRVSE	8.0	7.0	CD8	-	4298_17:3567983-3567983 T>G_DQDPSQNPFSEDTTDKGIYVTRVSE	1.0
16:3255067-3255067 C>G	0.0	4196	COLORECTAL	-	-	-	-	OR1F1	uc010uwu.2,p.A274G|NM_012360,p.A274G|ENST00000304646,p.A274G	protein_coding	uc010uwu.2	nonsynonymous SNV	exon1	c.C821G	p.A274G	PLSSHSAEKDTMATVLYTVVTPMLN	PLSSHSAEKDTMGTVLYTVVTPMLN	3.0	7.0	-	-	4196_16:3255067-3255067 C>G_PLSSHSAEKDTMGTVLYTVVTPMLN	0.0
12:7355295-7355295 A>C	1.0	2556	MELANOMA	-	-	-	-	PEX5	uc009zfu.2,p.I281L|ENST00000434354,p.I296L|ENST00000420616,p.I281L|NM_001131024,p.I244L|NM_001131026,p.I281L|uc001qsu.3,p.I244L|uc001qsw.3,p.I281L|NM_001131025,p.I281L|NM_001300789,p.I302L|ENST00000545574,p.I232L|ENST00000412720,p.I302L|ENST00000266563,p.I244L|NM_001131023,p.I296L|uc010sgd.2,p.I302L|uc010sgc.2,p.I296L|ENST00000455147,p.I281L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sgd.2	nonsynonymous SNV	exon9	c.A904C	p.I302L	ALDMEFERAKSAIESDVDFWDKLQA	ALDMEFERAKSALESDVDFWDKLQA	7.0	9.0	-	-	2556_12:7355295-7355295 A>C_ALDMEFERAKSALESDVDFWDKLQA	0.0
3:165547854-165547854 T>G	1.0	4213	COLORECTAL	-	-	-	-	BCHE	ENST00000482958,p.D323A|ENST00000264381,p.D323A|ENST00000497011,p.D323A|NM_000055,p.D323A|uc003fem.4,p.D323A	protein_coding, nonsense_mediated_decay	uc003fem.4	nonsynonymous SNV	exon2	c.A968C	p.D323A	GTPLSVNFGPTVDGDFLTDMPDILL	GTPLSVNFGPTVAGDFLTDMPDILL	7.0	9.0	-	-	4213_3:165547854-165547854 T>G_GTPLSVNFGPTVAGDFLTDMPDILL	0.0
15:86312840-86312840 T>C	0.0	4126	NSCLC	-	-	-	-	KLHL25	NM_022480,p.S68G|uc002bly.3,p.S68G|ENST00000337975,p.S68G|ENST00000536947,p.S68G|uc021stw.1,p.S68G	protein_coding, processed_transcript	uc021stw.1	nonsynonymous SNV	exon1	c.A202G	p.S68G	AFPCHRAVLAASSRYFEAMFSHGLR	AFPCHRAVLAASGRYFEAMFSHGLR	4.0	6.0	-	-	4126_15:86312840-86312840 T>C_AFPCHRAVLAASGRYFEAMFSHGLR	0.0
16:68225261-68225261 C>T	1.0	3713	MELANOMA	-	-	-	-	NFATC3	uc002evk.3,p.P897S|uc002evl.3,p.P418S|uc010vkn.2,p.P418S|uc010vlb.2,p.P418S|uc010vks.2,p.P418S|uc010vla.2,p.P418S|uc002evo.2,p.P897S|uc010vkx.2,p.P418S|uc002evn.2,p.P897S|uc010vko.2,p.P418S|uc010vkw.2,p.P418S|uc010vkr.2,p.P418S|uc010vku.2,p.P418S|ENST00000349223,p.P897S|ENST00000329524,p.P897S|uc010vlc.2,p.P418S|NM_173165,p.P897S|ENST00000346183,p.P897S|uc010vkv.2,p.P418S|NM_004555,p.P897S|uc010vky.2,p.P418S|uc010vkl.2,p.P418S|uc010vkp.2,p.P418S|uc010vkm.2,p.P418S|NM_173163,p.P897S|uc002evm.2,p.P897S|uc010vkq.2,p.P418S|uc010vkt.2,p.P418S|ENST00000575270,p.P897S|uc010vkz.2,p.P418S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vlc.2	nonsynonymous SNV	exon9	c.C1252T	p.P418S	HCSNTGQRSLSSPVADQITGQPSSQ	HCSNTGQRSLSSSVADQITGQPSSQ	7.0	4.0	-	-	3713_16:68225261-68225261 C>T_HCSNTGQRSLSSSVADQITGQPSSQ	0.0
1:11562034-11562034 T>C	0.0	4258	ENDOMETRIAL	-	-	-	-	PTCHD2	uc001ash.4,p.S329P|NM_020780,p.S329P|uc001asi.1,p.S329P|ENST00000389575,p.S329P|ENST00000294484,p.S329P	protein_coding, processed_transcript	uc001asi.1	nonsynonymous SNV	exon1	c.T985C	p.S329P	KPHEVLKDLPLGSYSYCSPPSSLMT	KPHEVLKDLPLGPYSYCSPPSSLMT	3.0	6.0	-	-	4258_1:11562034-11562034 T>C_KPHEVLKDLPLGPYSYCSPPSSLMT	0.0
19:55493003-55493003 G>A	0.0	3998	MELANOMA	-	-	-	-	NLRP2	ENST00000585500,p.G70E|ENST00000448584,p.G139E|ENST00000543010,p.G139E|ENST00000433772,p.G139E|NM_001174081,p.G139E|uc021vbq.1,p.G139E|ENST00000397169,p.G71E|ENST00000427260,p.G116E|uc002qij.3,p.G139E|uc010yfp.2,p.G116E|NM_017852,p.G139E|NM_001174083,p.G116E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vbq.1	nonsynonymous SNV	exon5	c.G416A	p.G139E	FKTEAQAFTETKGNVICLGKEVFKG	FKTEAQAFTETKENVICLGKEVFKG	3.0	9.0	-	-	3998_19:55493003-55493003 G>A_FKTEAQAFTETKENVICLGKEVFKG	0.0
4:48887517-48887517 T>C	1.0	4266	COLORECTAL	-	-	-	-	OCIAD2	uc003gyt.3,p.Q150R|ENST00000508632,p.Q150R|NM_001014446,p.Q150R|NM_001286774,p.Q88R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gyt.3	nonsynonymous SNV	exon7	c.A449G	p.Q150R	KIKHGLSEKGDSQPSAS	KIKHGLSEKGDSRPSAS	10.0	6.0	-	-	4266_4:48887517-48887517 T>C_KIKHGLSEKGDSRPSAS	0.0
16:31414857-31414857 C>G	0.0	4346	COLORECTAL	-	-	-	-	ITGAD	uc002ebv.1,p.H199D|uc010vfl.1,p.H199D|NM_005353,p.H199D|uc010cap.1,p.H199D|ENST00000389202,p.H199D	retained_intron, protein_coding	uc010vfl.1	nonsynonymous SNV	exon7	c.C595G	p.H199D	FALMQYSNLLKIHFTFTQFRTSPSQ	FALMQYSNLLKIDFTFTQFRTSPSQ	2.0	7.0	-	-	4346_16:31414857-31414857 C>G_FALMQYSNLLKIDFTFTQFRTSPSQ	0.0
7:43663437-43663437 G>C	1.0	4284	COLORECTAL	-	-	-	-	STK17A	ENST00000319357,p.L290F|uc003tih.3,p.L290F|NM_004760,p.L290F	retained_intron, protein_coding, processed_transcript	uc003tih.3	nonsynonymous SNV	exon6	c.G870C	p.L290F	MNLSYSEEEFDVLSESAVDFIRTLL	MNLSYSEEEFDVFSESAVDFIRTLL	6.0	6.0	-	-	4284_7:43663437-43663437 G>C_MNLSYSEEEFDVFSESAVDFIRTLL	0.0
1:8384513-8384513 C>T	0.0	4316	COLORECTAL	-	-	-	-	SLC45A1	ENST00000289877,p.R42W|uc001apb.3,p.R42W|ENST00000471889,p.R42W|NM_001080397,p.R76W|ENST00000377479,p.R76W	retained_intron, protein_coding, processed_transcript	uc001apb.3	nonsynonymous SNV	exon1	c.C124T	p.R42W	GYSGSVTRHLSHRANNFKRHPKRRK	GYSGSVTRHLSHWANNFKRHPKRRK	1.0	8.0	-	-	4316_1:8384513-8384513 C>T_GYSGSVTRHLSHWANNFKRHPKRRK	0.0
1:186278176-186278176 C>T	1.0	4095	COLORECTAL	-	-	-	-	PRG4	ENST00000367485,p.L1016F|NM_005807,p.L1109F|NM_001127709,p.L1016F|ENST00000367483,p.L1068F|ENST00000367484,p.L638F|uc009wyl.3,p.L1016F|ENST00000445192,p.L1109F|NM_001127708,p.L1068F|uc009wym.3,p.L975F|NM_001127710,p.L975F|ENST00000367486,p.L1066F|uc001gru.4,p.L1109F|uc001grt.4,p.L1068F	protein_coding	uc009wym.3	nonsynonymous SNV	exon4	c.C2923T	p.L975F	AGGAEGETPHMLLRPHVFMPEVTPD	AGGAEGETPHMLFRPHVFMPEVTPD	4.0	10.0	-	-	4095_1:186278176-186278176 C>T_AGGAEGETPHMLFRPHVFMPEVTPD	0.0
4:128811338-128811338 C>T	1.0	3713	MELANOMA	-	-	-	-	PLK4	NM_014264,p.P593S|ENST00000270861,p.P593S|NM_001190801,p.P552S|uc011cgs.2,p.P561S|NM_001190799,p.P561S|ENST00000514379,p.P552S|uc003ifo.3,p.P593S|uc011cgt.2,p.P552S|ENST00000513090,p.P561S|ENST00000507249,p.P559S|ENST00000515069,p.P515S	retained_intron, protein_coding, processed_transcript	uc011cgt.2	nonsynonymous SNV	exon7	c.C1654T	p.P552S	GYQNRTLRSITSPLVAHRLKPIRQK	GYQNRTLRSITSSLVAHRLKPIRQK	3.0	6.0	-	-	3713_4:128811338-128811338 C>T_GYQNRTLRSITSSLVAHRLKPIRQK	0.0
15:25959146-25959146 C>A	0.0	4126	NSCLC	-	-	-	-	ATP10A	NM_024490,p.Q673H|uc010ayu.3,p.Q673H|ENST00000356865,p.Q673H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ayu.3	nonsynonymous SNV	exon10	c.G2019T	p.Q673H	PTSAIASNGYSSQADNWASELAQEQ	PTSAIASNGYSSHADNWASELAQEQ	5.0	7.0	-	-	4126_15:25959146-25959146 C>A_PTSAIASNGYSSHADNWASELAQEQ	0.0
21:34166143-34166143 G>C	0.0	4077	BILE DUCT	-	-	-	-	C21orf62	ENST00000487113,p.P197R|NM_019596,p.P197R|ENST00000536776,p.P197R|uc021wik.1,p.P197R|ENST00000382373,p.P244R|ENST00000479548,p.P197R|uc011adu.2,p.P197R|NM_001162495,p.P197R|uc011adt.2,p.P197R|NM_001162496,p.P197R|ENST00000490358,p.P197R|uc010glz.3,p.P197R	protein_coding	uc021wik.1	nonsynonymous SNV	exon1	c.C590G	p.P197R	SIENVTSIANNFPDFSYFRTFPMPS	SIENVTSIANNFRDFSYFRTFPMPS	1.0	9.0	-	-	4077_21:34166143-34166143 G>C_SIENVTSIANNFRDFSYFRTFPMPS	0.0
2:85863205-85863205 C>A	1.0	4245	COLORECTAL	-	-	-	-	USP39	uc010ysv.3,p.L224M|uc002sqg.4,p.L327M|ENST00000409025,p.L327M|NM_001256726,p.L327M|uc002sqb.4,p.L58M|NM_001256727,p.L249M|NM_001256725,p.L327M|uc010fgn.2,p.L327M|ENST00000450066,p.L224M|ENST00000409470,p.L327M|uc010fgo.4,p.L327M|uc010ysu.3,p.L249M|ENST00000323701,p.L327M|ENST00000409766,p.L327M|NM_001256728,p.L224M|uc002sqe.4,p.L327M|NM_006590,p.L327M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ysv.3	nonsynonymous SNV	exon6	c.C670A	p.L224M	KQGDGVDFLSWFLNALHSALGGTKK	KQGDGVDFLSWFMNALHSALGGTKK	9.0	3.0	-	-	4245_2:85863205-85863205 C>A_KQGDGVDFLSWFMNALHSALGGTKK	0.0
1:16725304-16725304 C>T	0.0	4240	BREAST	-	-	-	-	SPATA21	ENST00000335496,p.D456N|uc010occ.2,p.D433N|NM_198546,p.D456N|ENST00000540400,p.D433N|uc001ayn.3,p.D456N	protein_coding, processed_transcript	uc010occ.2	nonsynonymous SNV	exon11	c.G1297A	p.D433N	QSGSQGNREHNSDSRKWLSSVPART	QSGSQGNREHNSNSRKWLSSVPART	3.0	9.0	-	-	4240_1:16725304-16725304 C>T_QSGSQGNREHNSNSRKWLSSVPART	0.0
10:1065733-1065735 GTG>-	1.0	4317	COLORECTAL	-	-	-	-	IDI2	ENST00000277517,p.136_136del|NM_033261,p.136_136del|uc001ifv.1,p.136_136del	protein_coding	uc001ifv.1	nonframeshift deletion	exon5	c.406_408del	p.136_136del	SPEDIVFMTIYHHKAKSDRIWGEHE	SPEDIVFMTIYHKAKSDRIWGEHEI	1.0	6.0	-	-	4317_10:1065733-1065735 GTG>-_SPEDIVFMTIYHKAKSDRIWGEHEI	0.0
14:95918626-95918626 G>A	0.0	4186	BREAST	-	-	-	-	SYNE3	uc001yej.1,p.P411L|uc010avi.3,p.P411L|ENST00000557275,p.P411L|uc001yei.4,p.P411L|ENST00000554873,p.P168L|ENST00000334258,p.P411L|NM_152592,p.P411L|ENST00000553340,p.P411L	retained_intron, protein_coding	uc010avi.3	nonsynonymous SNV	exon6	c.C1232T	p.P411L	LKELIVFPHNLKPLSDSVIATIQEY	LKELIVFPHNLKLLSDSVIATIQEY	2.0	4.0	-	-	4186_14:95918626-95918626 G>A_LKELIVFPHNLKLLSDSVIATIQEY	0.0
7:140058531-140058551 ACAGCCATTTGTTGTAGAAAC>-	0.0	4320	COLORECTAL	-	-	-	-	SLC37A3	ENST00000326232,p.137_144del|NM_207113,p.137_144del|NM_001287498,p.137_144del|ENST00000484416,p.40_47del|uc011kra.1,p.137_144del|uc010lnh.3,p.137_144del|uc003vvp.3,p.137_144del|uc003vvo.3,p.137_144del|NM_032295,p.137_144del|uc011krb.1,p.109_116del|ENST00000447932,p.137_144del|ENST00000340308,p.137_144del|ENST00000477571,p.137_144del	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011krb.1	nonframeshift deletion	exon5	c.326_346del	p.109_116del	VVFVFGALTEWLRFYNKWLYCCLWI	VVFVFGALTEWLHCCLWIVNGLLQS	9.0	1.0	CD8	-	4320_7:140058531-140058551 ACAGCCATTTGTTGTAGAAAC>-_VVFVFGALTEWLHCCLWIVNGLLQS	1.0
5:134914452-134914452 G>T	1.0	4287	COLORECTAL	-	-	-	-	CXCL14	uc003lay.3,p.A18D|ENST00000337225,p.A18D|NM_004887,p.A18D	protein_coding	uc003lay.3	nonsynonymous SNV	exon1	c.C53A	p.A18D	RRAPPVSMRLLAAALLLLLLALYTA	RRAPPVSMRLLADALLLLLLALYTA	4.0	4.0	-	-	4287_5:134914452-134914452 G>T_RRAPPVSMRLLADALLLLLLALYTA	0.0
3:151148130-151148130 C>T	1.0	4213	COLORECTAL	-	-	ID=COSM3784362;OCCURENCE=1(pancreas)	-	MED12L	uc011bnz.2,p.T1780M|NM_053002,p.T2116M|uc003eyp.3,p.T2116M|ENST00000474524,p.T2116M|ENST00000273432,p.T1780M	protein_coding, processed_transcript	uc011bnz.2	nonsynonymous SNV	exon36	c.C5339T	p.T1780M	RQGLQQTQQQQQTAALVRQLQKQLS	RQGLQQTQQQQQMAALVRQLQKQLS	3.0	10.0	-	-	4213_3:151148130-151148130 C>T_RQGLQQTQQQQQMAALVRQLQKQLS	0.0
X:152770240-152770240 G>A	0.0	4189	MELANOMA	-	-	-	-	BGN	NM_001711,p.D51N|ENST00000431891,p.D51N|ENST00000331595,p.D51N|uc004fhr.2,p.D51N	protein_coding, processed_transcript	uc004fhr.2	nonsynonymous SNV	exon2	c.G151A	p.D51N	EEASGADTSGVLDPDSVTPTYSAMC	EEASGADTSGVLNPDSVTPTYSAMC	10.0	10.0	-	-	4189_X:152770240-152770240 G>A_EEASGADTSGVLNPDSVTPTYSAMC	0.0
4:5710044-5710044 C>T	0.0	4298	COLORECTAL	-	-	-	-	EVC2	ENST00000344408,p.R66Q|uc003gij.3,p.R66Q|ENST00000344938,p.R66Q|NM_147127,p.R66Q	protein_coding, nonsense_mediated_decay	uc003gij.3	nonsynonymous SNV	exon1	c.G197A	p.R66Q	PRSGPGLRIPPGRSGAGPESSTQDL	PRSGPGLRIPPGQSGAGPESSTQDL	5.0	4.0	-	-	4298_4:5710044-5710044 C>T_PRSGPGLRIPPGQSGAGPESSTQDL	0.0
15:32738755-32738757 CTC>-	0.0	4298	COLORECTAL	-	-	-	-	GOLGA8O	NM_001277308,p.429_430del|ENST00000509311,p.429_430del|uc031qrg.1,p.429_430del	protein_coding	uc031qrg.1	nonframeshift deletion	exon15	c.1286_1288del	p.429_430del	LSLMALPGEGHGGEHLDSEGEEAPR	LSLMALPGEGHGEHLDSEGEEAPRP	9.0	1.0	-	-	4298_15:32738755-32738757 CTC>-_LSLMALPGEGHGEHLDSEGEEAPRP	0.0
X:128630792-128630792 A>C	1.0	4110	BILE DUCT	-	-	-	-	SMARCA1	ENST00000371121,p.Y521D|uc004eup.4,p.Y521D|NM_001282875,p.Y521D|ENST00000371122,p.Y521D|uc004eun.4,p.Y521D|uc011muk.1,p.Y521D|ENST00000371123,p.Y521D|uc011mul.1,p.Y521D|NM_003069,p.Y521D|ENST00000450039,p.Y500D|NM_001282874,p.Y521D	protein_coding, processed_transcript	uc011mul.1	nonsynonymous SNV	exon12	c.T1561G	p.Y521D	SQMTRLLDILEDYCMWRGYEYCRLD	SQMTRLLDILEDDCMWRGYEYCRLD	8.0	10.0	-	-	4110_X:128630792-128630792 A>C_SQMTRLLDILEDDCMWRGYEYCRLD	0.0
2:96992590-96992590 A>C	0.0	4245	COLORECTAL	-	-	-	-	ITPRIPL1	uc002svy.3,p.N82T|uc010yul.2,p.N66T|NM_178495,p.N82T|ENST00000542887,p.N66T|NM_001008949,p.N74T|ENST00000536814,p.N66T|ENST00000439118,p.N74T|ENST00000420176,p.N66T|ENST00000361124,p.N82T|uc002svx.3,p.N74T|NM_001163523,p.N66T|NM_001163524,p.N66T|uc010yuk.2,p.N66T	protein_coding	uc010yul.2	nonsynonymous SNV	exon2	c.A197C	p.N66T	RKRAAEQRQKAENFWTGDTSSDQLV	RKRAAEQRQKAETFWTGDTSSDQLV	4.0	4.0	-	-	4245_2:96992590-96992590 A>C_RKRAAEQRQKAETFWTGDTSSDQLV	0.0
2:125204405-125204405 A>T	1.0	4213	COLORECTAL	-	-	-	-	CNTNAP5	uc002tno.3,p.H270L|NM_130773,p.H270L|ENST00000431078,p.H270L|uc010flu.3,p.H270L	retained_intron, protein_coding, processed_transcript	uc010flu.3	nonsynonymous SNV	exon6	c.A809T	p.H270L	ATLGSLLDDQHWHSVLIERVGKQVN	ATLGSLLDDQHWLSVLIERVGKQVN	3.0	5.0	-	-	4213_2:125204405-125204405 A>T_ATLGSLLDDQHWLSVLIERVGKQVN	0.0
2:170042241-170042241 C>T	0.0	4278	COLORECTAL	-	-	-	-	LRP2	NM_004525,p.R3206H|ENST00000263816,p.R3206H|uc002ues.3,p.R3206H	retained_intron, protein_coding, processed_transcript	uc002ues.3	nonsynonymous SNV	exon50	c.G9617A	p.R3206H	NSNIEPYLIFSNRYYLRNLTIDGYF	NSNIEPYLIFSNHYYLRNLTIDGYF	6.0	4.0	-	-	4278_2:170042241-170042241 C>T_NSNIEPYLIFSNHYYLRNLTIDGYF	0.0
11:92533545-92533545 C>A	0.0	3919	MELANOMA	-	-	-	2	FAT3	NM_001008781,p.H2456N|uc001pdj.4,p.H2456N|ENST00000298047,p.H2456N|ENST00000409404,p.H2456N|ENST00000525166,p.H2306N	retained_intron, protein_coding, processed_transcript	uc001pdj.4	nonsynonymous SNV	exon9	c.C7366A	p.H2456N	MDSKSGVITLSNHRKQRMEPLYSLN	MDSKSGVITLSNNRKQRMEPLYSLN	1.0	5.0	-	-	3919_11:92533545-92533545 C>A_MDSKSGVITLSNNRKQRMEPLYSLN	0.0
5:54570829-54570829 G>A	1.0	3713	MELANOMA	-	-	-	-	DHX29	uc003jpx.3,p.P813S|NM_019030,p.P813S|ENST00000251636,p.P813S	retained_intron, protein_coding	uc003jpx.3	nonsynonymous SNV	exon15	c.C2437T	p.P813S	KAGGIKKYQEYIPVQTGAHADLNPF	KAGGIKKYQEYISVQTGAHADLNPF	5.0	10.0	-	-	3713_5:54570829-54570829 G>A_KAGGIKKYQEYISVQTGAHADLNPF	0.0
3:11301264-11301264 G>A	1.0	3466	MELANOMA	-	-	-	-	HRH1	uc003bwb.4,p.E181K|uc010hdr.3,p.E181K|uc010hdt.3,p.E181K|uc021wtb.1,p.E181K|NM_001098212,p.E181K|NM_000861,p.E181K|ENST00000431010,p.E181K|uc010hds.3,p.E181K|NM_001098213,p.E181K|NM_001098211,p.E181K|ENST00000397056,p.E181K|ENST00000438284,p.E181K	protein_coding	uc021wtb.1	nonsynonymous SNV	exon1	c.G541A	p.E181K	MQQTSVRREDKCETDFYDVTWFKVM	MQQTSVRREDKCKTDFYDVTWFKVM	6.0	4.0	-	-	3466_3:11301264-11301264 G>A_MQQTSVRREDKCKTDFYDVTWFKVM	0.0
16:1504418-1504418 C>T	1.0	4244	COLORECTAL	-	-	ID=COSM1637474;OCCURENCE=1(bone)	-	CLCN7	ENST00000382745,p.V383M|NM_001114331,p.V359M|ENST00000448525,p.V359M|ENST00000262318,p.V359M|uc002clv.3,p.V383M|NM_001287,p.V383M|uc002clw.3,p.V359M	retained_intron, protein_coding, processed_transcript	uc002clw.3	nonsynonymous SNV	exon12	c.G1075A	p.V359M	TIHEIPVFIAMGVVGGVLGAVFNAL	TIHEIPVFIAMGMVGGVLGAVFNAL	9.0	7.0	-	-	4244_16:1504418-1504418 C>T_TIHEIPVFIAMGMVGGVLGAVFNAL	0.0
1:181767893-181767893 G>A	0.0	4275	COLORECTAL	-	-	-	-	CACNA1E	ENST00000367570,p.G2246R|NM_000721,p.G2246R|uc009wxt.3,p.G2289R|NM_001205294,p.G2227R|ENST00000360108,p.G2270R|ENST00000357570,p.G2240R|ENST00000367573,p.G2289R|uc001gow.3,p.G2246R|ENST00000367567,p.G1853R|ENST00000358338,p.G2178R|ENST00000526775,p.G2227R|uc009wxs.3,p.G2227R|NM_001205293,p.G2289R	retained_intron, protein_coding	uc009wxt.3	nonsynonymous SNV	exon48	c.G6865A	p.G2289R	QMPNGHYRRRRRGGPGPGMMCGAVN	QMPNGHYRRRRRRGPGPGMMCGAVN	3.0	9.0	-	-	4275_1:181767893-181767893 G>A_QMPNGHYRRRRRRGPGPGMMCGAVN	0.0
2:85857865-85857865 C>T	1.0	3466	MELANOMA	-	-	-	-	USP39	NM_001256728,p.L146F|uc002sqg.4,p.L249F|uc010ysv.3,p.L146F|ENST00000409766,p.L249F|ENST00000323701,p.L249F|ENST00000409470,p.L249F|NM_001256725,p.L249F|ENST00000450066,p.L146F|uc002sqe.4,p.L249F|uc010fgn.2,p.L249F|NM_006590,p.L249F|uc010fgo.4,p.L249F|NM_001256727,p.L171F|NM_001256726,p.L249F|ENST00000409025,p.L249F|uc010ysu.3,p.L171F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ysv.3	nonsynonymous SNV	exon5	c.C436T	p.L146F	NAVLQALSNVPPLRNYFLEEDNYKN	NAVLQALSNVPPFRNYFLEEDNYKN	9.0	6.0	-	-	3466_2:85857865-85857865 C>T_NAVLQALSNVPPFRNYFLEEDNYKN	0.0
3:168812989-168812989 T>C	1.0	3713	MELANOMA	-	-	-	1	MECOM	uc011bpk.1,p.Q777R|ENST00000472280,p.Q778R|ENST00000468789,p.Q777R|NM_005241,p.Q777R|NM_001164000,p.Q768R|uc003ffn.3,p.Q777R|uc003ffj.3,p.Q842R|ENST00000392736,p.Q777R|uc011bpj.1,p.Q965R|uc010hwk.1,p.Q791R|NM_001205194,p.Q777R|ENST00000433243,p.Q778R|uc011bpi.1,p.Q769R|NM_001105078,p.Q777R|uc003ffk.2,p.Q768R|ENST00000264674,p.Q842R|ENST00000494292,p.Q956R|NM_001163999,p.Q769R|NM_004991,p.Q965R|uc003ffi.3,p.Q777R|ENST00000464456,p.Q768R|ENST00000460814,p.Q768R|uc003ffl.2,p.Q928R|NM_001105077,p.Q842R	retained_intron, protein_coding, processed_transcript	uc011bpk.1	nonsynonymous SNV	exon12	c.A2330G	p.Q777R	YCDRSFSISSNLQRHVRNIHNKEKP	YCDRSFSISSNLRRHVRNIHNKEKP	2.0	9.0	-	-	3713_3:168812989-168812989 T>C_YCDRSFSISSNLRRHVRNIHNKEKP	0.0
20:44258475-44258475 C>T	0.0	4213	COLORECTAL	-	-	-	-	WFDC10A	NM_080753,p.P8L|ENST00000372643,p.P8L|uc002xoz.3,p.P8L	protein_coding	uc002xoz.3	nonsynonymous SNV	exon1	c.C23T	p.P8L	MAPQTLLPVLVLCVLLLQAQ	MAPQTLLLVLVLCVLLLQAQ	1.0	9.0	-	-	4213_20:44258475-44258475 C>T_MAPQTLLLVLVLCVLLLQAQ	0.0
17:17720579-17720579 C>T	1.0	4320	COLORECTAL	-	-	-	-	SREBF1	ENST00000338854,p.E533K|uc002grr.2,p.E279K|uc002grp.2,p.E152K|uc002grt.2,p.E563K|uc002grq.2,p.E52K|ENST00000261646,p.E533K|ENST00000355815,p.E563K|NM_004176,p.E533K|NM_001005291,p.E563K|uc002gru.2,p.E533K|uc002grs.2,p.E509K|ENST00000395757,p.E279K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002gru.2	nonsynonymous SNV	exon8	c.G1597A	p.E533K	VYHSPGRNVLGTESRDGPGWAQWLL	VYHSPGRNVLGTKSRDGPGWAQWLL	9.0	10.0	-	-	4320_17:17720579-17720579 C>T_VYHSPGRNVLGTKSRDGPGWAQWLL	0.0
20:49576739-49576739 G>A	0.0	3775	CERVICAL	-	-	-	-	MOCS3	ENST00000244051,p.D454N|uc002xvy.2,p.D454N|NM_014484,p.D454N	protein_coding	uc002xvy.2	nonsynonymous SNV	exon1	c.G1360A	p.D454N	VVGGLMAWAAKIDGTFPQY	VVGGLMAWAAKINGTFPQY	5.0	5.0	-	-	3775_20:49576739-49576739 G>A_VVGGLMAWAAKINGTFPQY	0.0
19:15582896-15582896 T>A	0.0	4245	COLORECTAL	-	-	-	-	PGLYRP2	NM_052890,p.H383L|ENST00000292609,p.H383L|uc002nbg.3,p.H383L|uc002nbf.4,p.H383L|ENST00000340880,p.H383L	protein_coding	uc002nbg.3	nonsynonymous SNV	exon3	c.A1148T	p.H383L	EFTEAFLGCPAIHPRCRWGAAPYRG	EFTEAFLGCPAILPRCRWGAAPYRG	3.0	3.0	-	-	4245_19:15582896-15582896 T>A_EFTEAFLGCPAILPRCRWGAAPYRG	0.0
13:49776075-49776075 C>T	1.0	3919	MELANOMA	-	-	-	-	FNDC3A	NM_014923,p.P987S|NM_001079673,p.P1043S|ENST00000541916,p.P1043S|ENST00000398316,p.P987S|uc001vcq.3,p.P987S|ENST00000492622,p.P1043S|uc001vcm.3,p.P1043S|NM_001278438,p.P1043S|uc001vcn.3,p.P1043S	retained_intron, protein_coding, nonsense_mediated_decay	uc001vcq.3	nonsynonymous SNV	exon22	c.C2959T	p.P987S	EGPLSQEYIFTTPKSVPAALKAPKI	EGPLSQEYIFTTSKSVPAALKAPKI	9.0	9.0	-	-	3919_13:49776075-49776075 C>T_EGPLSQEYIFTTSKSVPAALKAPKI	0.0
19:45324009-45324009 A>G	0.0	4329	COLORECTAL	-	-	-	-	BCAM	ENST00000270233,p.E604G|uc002ozu.4,p.E604G|NM_005581,p.E604G	retained_intron, protein_coding, nonsense_mediated_decay	uc002ozu.4	nonsynonymous SNV	exon14	c.A1811G	p.E604G	EPGLSHSGSEQPEQTGLLMGGASGG	EPGLSHSGSEQPGQTGLLMGGASGG	8.0	4.0	-	-	4329_19:45324009-45324009 A>G_EPGLSHSGSEQPGQTGLLMGGASGG	0.0
12:70206792-70206792 G>A	0.0	4155	MELANOMA	-	-	-	-	RAB3IP	uc001svm.3,p.G427R|NM_001278402,p.G221R|ENST00000551641,p.G221R|ENST00000550847,p.G134R|ENST00000247833,p.G427R|uc001svt.3,p.G221R|ENST00000553099,p.G221R|uc001svp.3,p.G443R|NM_175623,p.G443R|NM_022456,p.G427R|NM_001024647,p.G221R|ENST00000550536,p.G443R|ENST00000325555,p.G221R	retained_intron, nonsense_mediated_decay, protein_coding	uc001svt.3	nonsynonymous SNV	exon8	c.G661A	p.G221R	CNFFTYIRYIQQGLVKQQDVDQMFW	CNFFTYIRYIQQRLVKQQDVDQMFW	7.0	7.0	-	-	4155_12:70206792-70206792 G>A_CNFFTYIRYIQQRLVKQQDVDQMFW	0.0
9:79955378-79955378 C>T	1.0	3903	MELANOMA	-	-	-	-	VPS13A	ENST00000376634,p.P2313L|ENST00000360280,p.P2313L|NM_001018038,p.P2313L|NM_033305,p.P2313L|uc004akr.3,p.P2313L|uc004akq.4,p.P2313L|ENST00000357409,p.P2313L|uc004akp.4,p.P2313L|NM_001018037,p.P2274L|ENST00000376636,p.P2274L|uc004aks.3,p.P2274L|NM_015186,p.P2313L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004aks.3	nonsynonymous SNV	exon49	c.C6821T	p.P2274L	SSFNITRIVTFTPFYMIKNKSKYHI	SSFNITRIVTFTLFYMIKNKSKYHI	6.0	10.0	-	-	3903_9:79955378-79955378 C>T_SSFNITRIVTFTLFYMIKNKSKYHI	0.0
6:136597198-136597198 T>C	1.0	4081	COLORECTAL	-	-	-	2	BCLAF1	NM_014739,p.T489A|uc003qgx.1,p.T489A|ENST00000531224,p.T489A|ENST00000527536,p.T489A|ENST00000527759,p.T487A|ENST00000529826,p.T489A|uc003qgy.1,p.T487A|ENST00000353331,p.T487A|ENST00000530429,p.T487A|ENST00000527613,p.T489A|uc011ede.1,p.T487A|NM_001301038,p.T487A|ENST00000392348,p.T487A|NM_001077440,p.T487A|ENST00000532384,p.T489A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ede.1	nonsynonymous SNV	exon5	c.A1459G	p.T487A	KHKEEDKNSERITVKKETQSPEQVK	KHKEEDKNSERIAVKKETQSPEQVK	10.0	2.0	-	-	4081_6:136597198-136597198 T>C_KHKEEDKNSERIAVKKETQSPEQVK	0.0
X:12736762-12736762 G>A	0.0	4259	COLORECTAL	-	-	-	-	FRMPD4	uc004cuz.2,p.A1273T|NM_014728,p.A1273T|ENST00000380682,p.A1273T|uc011mij.2,p.A1265T	protein_coding	uc011mij.2	nonsynonymous SNV	exon17	c.G3793A	p.A1265T	SEERAPGLPNHGATFKELHPQTEGM	SEERAPGLPNHGTTFKELHPQTEGM	2.0	4.0	-	-	4259_X:12736762-12736762 G>A_SEERAPGLPNHGTTFKELHPQTEGM	0.0
17:41957307-41957307 T>G	0.0	4246	COLORECTAL	-	-	-	-	MPP2	uc010wim.1,p.Y388S|ENST00000377184,p.Y416S|NM_001278381,p.Y399S|ENST00000269095,p.Y399S|uc010win.1,p.Y260S|NM_001278371,p.Y388S|NM_001278370,p.Y444S|uc002ieo.1,p.Y399S|NM_001278375,p.Y388S|uc002ien.1,p.Y416S|NM_001278372,p.Y423S|NM_001278373,p.Y388S|ENST00000536246,p.Y388S|NM_001278374,p.Y260S|ENST00000520305,p.Y260S|ENST00000461854,p.Y423S|uc010wio.1,p.Y388S|ENST00000523501,p.Y388S|NM_001278376,p.Y416S|ENST00000518766,p.Y444S|NM_005374,p.Y399S|uc010wip.1,p.Y444S	retained_intron, protein_coding, processed_transcript	uc010wip.1	nonsynonymous SNV	exon11	c.A1331C	p.Y444S	RRPKDSEREGQGYSFVSRGEMEADV	RRPKDSEREGQGSSFVSRGEMEADV	2.0	2.0	-	-	4246_17:41957307-41957307 T>G_RRPKDSEREGQGSSFVSRGEMEADV	0.0
21:47848442-47848442 G>A	0.0	4158	COLORECTAL	-	-	-	-	PCNT	uc002zji.4,p.R2543H|NM_006031,p.R2543H|ENST00000359568,p.R2543H|uc002zjj.3,p.R2425H	retained_intron, protein_coding, processed_transcript	uc002zjj.3	nonsynonymous SNV	exon35	c.G7274A	p.R2425H	THLQNQEKLQHLRTALTSAEARGSQ	THLQNQEKLQHLHTALTSAEARGSQ	6.0	9.0	-	-	4158_21:47848442-47848442 G>A_THLQNQEKLQHLHTALTSAEARGSQ	0.0
5:7861353-7861353 G>A	1.0	3903	MELANOMA	-	-	-	-	FASTKD3	uc011cmp.2,p.P300L|ENST00000264669,p.P598L|uc003jeb.3,p.P598L|NM_024091,p.P598L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cmp.2	nonsynonymous SNV	exon6	c.C899T	p.P300L	DIHKRIALCIDGPKRFCSNSKHLLG	DIHKRIALCIDGLKRFCSNSKHLLG	7.0	6.0	-	-	3903_5:7861353-7861353 G>A_DIHKRIALCIDGLKRFCSNSKHLLG	0.0
X:12828249-12828249 G>A	1.0	4287	COLORECTAL	-	-	ID=COSM1465490;OCCURENCE=1(large_intestine)	-	PRPS2	uc010nec.3,p.A108T|ENST00000461630,p.A85T	protein_coding, processed_transcript	uc010nec.3	nonsynonymous SNV	exon3	c.G322A	p.A108T	AEWKNCIIVSPDAGGAKRLLSAGAT	AEWKNCIIVSPDTGGAKRLLSAGAT	9.0	9.0	-	-	4287_X:12828249-12828249 G>A_AEWKNCIIVSPDTGGAKRLLSAGAT	0.0
1:226349232-226349232 T>G	1.0	4335	COLORECTAL	-	-	-	-	ACBD3	ENST00000366812,p.K243T|uc001hpy.3,p.K243T|NM_022735,p.K243T	protein_coding, processed_transcript	uc001hpy.3	nonsynonymous SNV	exon4	c.A728C	p.K243T	RIEEERLRLEQQKQQIMAALNSQTA	RIEEERLRLEQQTQQIMAALNSQTA	7.0	2.0	-	-	4335_1:226349232-226349232 T>G_RIEEERLRLEQQTQQIMAALNSQTA	0.0
4:85707194-85707194 G>C	0.0	4186	BREAST	-	-	-	-	WDFY3	NM_014991,p.L1334V|ENST00000295888,p.L1334V|ENST00000322366,p.L1334V|uc003hpd.3,p.L1334V	retained_intron, protein_coding, processed_transcript	uc003hpd.3	nonsynonymous SNV	exon24	c.C4000G	p.L1334V	VSFGLYALSVSSLTVARIRKVYNKL	VSFGLYALSVSSVTVARIRKVYNKL	6.0	4.0	-	-	4186_4:85707194-85707194 G>C_VSFGLYALSVSSVTVARIRKVYNKL	0.0
1:232626694-232626694 T>C	0.0	4258	ENDOMETRIAL	-	-	-	-	SIPA1L2	ENST00000366630,p.S578G|NM_020808,p.S578G|uc001hvg.3,p.S578G|ENST00000262861,p.S578G	protein_coding, processed_transcript	uc001hvg.3	nonsynonymous SNV	exon3	c.A1732G	p.S578G	LKEVLEYVIPELSIQCLRQASNSPK	LKEVLEYVIPELGIQCLRQASNSPK	6.0	4.0	-	-	4258_1:232626694-232626694 T>C_LKEVLEYVIPELGIQCLRQASNSPK	0.0
3:88040609-88040609 G>A	1.0	4252	COLORECTAL	-	-	-	-	HTR1F	uc003dqr.2,p.S237N|ENST00000319595,p.S237N|NM_000866,p.S237N|uc021xbd.1,p.S237N	protein_coding	uc021xbd.1	nonsynonymous SNV	exon1	c.G710A	p.S237N	VNGQVLLESGEKSTKSVSTSYVLEK	VNGQVLLESGEKNTKSVSTSYVLEK	4.0	9.0	-	-	4252_3:88040609-88040609 G>A_VNGQVLLESGEKNTKSVSTSYVLEK	0.0
14:105414926-105414926 C>A	0.0	4235	COLORECTAL	-	-	-	-	AHNAK2	uc001ypx.2,p.V2188F|uc010axc.1,p.V2288F|NM_138420,p.V2288F|ENST00000333244,p.V2288F	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.G6862T	p.V2288F	DVEVSLPSVEVDVKAPGAKLDGARL	DVEVSLPSVEVDFKAPGAKLDGARL	9.0	7.0	-	-	4235_14:105414926-105414926 C>A_DVEVSLPSVEVDFKAPGAKLDGARL	0.0
5:140201539-140201539 C>T	0.0	4316	COLORECTAL	-	-	-	-	PCDHA5	ENST00000529859,p.P60L|NM_031501,p.P60L|ENST00000378126,p.P60L|uc003lhj.1,p.P60L|NM_018908,p.P60L|uc003lhl.2,p.P60L|uc003lhk.1,p.P60L|ENST00000529619,p.P60L	protein_coding	uc003lhl.2	nonsynonymous SNV	exon1	c.C179T	p.P60L	AQDLGLELAELVPRLFRVASKGRGD	AQDLGLELAELVLRLFRVASKGRGD	5.0	9.0	-	-	4316_5:140201539-140201539 C>T_AQDLGLELAELVLRLFRVASKGRGD	0.0
10:5435709-5435709 G>A	0.0	4326	BREAST	0.0005	-	-	-	TUBAL3	ENST00000479328,p.P331L|NM_024803,p.P371L|ENST00000380419,p.P371L|uc001ihy.3,p.P371L|uc001ihz.3,p.P331L|NM_001171864,p.P331L	protein_coding	uc001ihz.3	nonsynonymous SNV	exon4	c.C992T	p.P331L	KVGINNRPPTVMPGGDLAKVHRSIC	KVGINNRPPTVMLGGDLAKVHRSIC	4.0	9.0	-	-	4326_10:5435709-5435709 G>A_KVGINNRPPTVMLGGDLAKVHRSIC	0.0
11:36614963-36614963 C>G	0.0	4078	GASTRIC	-	-	-	-	RAG2	NM_001243785,p.L252F|ENST00000311485,p.L252F|uc021qge.1,p.L252F|uc021qgc.1,p.L252F|NM_001243786,p.L252F|NM_000536,p.L252F|uc021qgd.1,p.L252F|uc001mwv.4,p.L252F	protein_coding, processed_transcript	uc021qge.1	nonsynonymous SNV	exon1	c.G756C	p.L252F	LPLGSPAVNCTVLPGGISVSSAILT	LPLGSPAVNCTVFPGGISVSSAILT	1.0	6.0	-	-	4078_11:36614963-36614963 C>G_LPLGSPAVNCTVFPGGISVSSAILT	0.0
11:66258783-66258783 C>T	1.0	3678	MELANOMA	-	-	-	-	DPP3	ENST00000453114,p.P243S|NM_005700,p.P243S|uc001oig.2,p.P243S|uc001oif.2,p.P243S|ENST00000360510,p.P243S|NM_130443,p.P243S|uc010rpe.2,p.P213S|NM_001256670,p.P213S|ENST00000533725,p.P141S|ENST00000531863,p.P263S|ENST00000530165,p.P213S|ENST00000541961,p.P243S|ENST00000532677,p.P262S	retained_intron, protein_coding, processed_transcript	uc010rpe.2	nonsynonymous SNV	exon6	c.C637T	p.P213S	TSKLKSYEFRGSPFQVTRGDYAPIL	TSKLKSYEFRGSSFQVTRGDYAPIL	8.0	10.0	-	-	3678_11:66258783-66258783 C>T_TSKLKSYEFRGSSFQVTRGDYAPIL	0.0
1:228466935-228466935 G>T	0.0	4155	MELANOMA	-	-	-	-	OBSCN	uc009xez.2,p.A2396S|NM_001271223,p.A2825S|uc001hsq.2,p.A2825S|ENST00000366706,p.A244S|ENST00000422127,p.A2396S|ENST00000284548,p.A2396S|uc001hsp.2,p.A184S|ENST00000570156,p.A2825S|NM_001098623,p.A2396S|ENST00000359599,p.A1243S|uc001hsn.4,p.A2396S|NM_052843,p.A2396S	retained_intron, protein_coding, processed_transcript	uc009xez.2	nonsynonymous SNV	exon27	c.G7186T	p.A2396S	GLQDVTVMEPAPAWFECETSIPSVR	GLQDVTVMEPAPSWFECETSIPSVR	8.0	7.0	-	-	4155_1:228466935-228466935 G>T_GLQDVTVMEPAPSWFECETSIPSVR	0.0
2:113832396-113832396 A>T	0.0	4301	MELANOMA	-	-	-	-	IL1F10	uc002tiw.3,p.E64V|ENST00000337569,p.E72V|ENST00000341010,p.E72V|uc002tiu.3,p.E72V|ENST00000393197,p.E72V|NM_032556,p.E72V|uc002tiv.3,p.E72V|NM_173161,p.E72V	retained_intron, protein_coding	uc002tiw.3	nonsynonymous SNV	exon1	c.A191T	p.E64V	GIQGGSRCLACVETEEGPSLQLEDV	GIQGGSRCLACVVTEEGPSLQLEDV	1.0	9.0	-	-	4301_2:113832396-113832396 A>T_GIQGGSRCLACVVTEEGPSLQLEDV	0.0
2:228882211-228882211 G>A	0.0	3903	MELANOMA	-	-	-	-	SPHKAP	NM_001142644,p.S1120L|uc010zlx.1,p.S1120L|uc002vpp.2,p.S1120L|NM_030623,p.S1120L|ENST00000344657,p.S1120L|ENST00000392056,p.S1120L|uc002vpq.2,p.S1120L	retained_intron, protein_coding	uc010zlx.1	nonsynonymous SNV	exon7	c.C3359T	p.S1120L	QPVSRASSVSKQSSCESITDEFSRF	QPVSRASSVSKQLSCESITDEFSRF	1.0	9.0	-	-	3903_2:228882211-228882211 G>A_QPVSRASSVSKQLSCESITDEFSRF	0.0
15:44955682-44955682 C>T	1.0	3919	MELANOMA	-	-	-	-	SPG11	NM_001160227,p.G55E|NM_025137,p.G55E|uc010uei.2,p.G55E|uc010ueh.2,p.G55E|ENST00000558319,p.G55E|ENST00000535302,p.G55E|uc001ztx.3,p.G55E|ENST00000261866,p.G55E|ENST00000427534,p.G55E|uc001zua.1,p.G55E|ENST00000559193,p.G55E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc010uei.2	nonsynonymous SNV	exon1	c.G164A	p.G55E	SRAQLRTQPEALGSLTAAGSLQVLS	SRAQLRTQPEALESLTAAGSLQVLS	8.0	2.0	-	-	3919_15:44955682-44955682 C>T_SRAQLRTQPEALESLTAAGSLQVLS	0.0
17:48262928-48262928 G>A	1.0	3713	MELANOMA	-	-	-	1	COL1A1	ENST00000225964,p.P1444S|NM_000088,p.P1444S|uc002iqm.3,p.P1444S	retained_intron, protein_coding	uc002iqm.3	nonsynonymous SNV	exon51	c.C4330T	p.P1444S	TKTSRLPIIDVAPLDVGAPDQEFGF	TKTSRLPIIDVASLDVGAPDQEFGF	10.0	2.0	-	-	3713_17:48262928-48262928 G>A_TKTSRLPIIDVASLDVGAPDQEFGF	0.0
12:86373857-86373857 G>T	0.0	4213	COLORECTAL	-	-	-	-	MGAT4C	ENST00000552808,p.T216N|uc001tak.4,p.T216N|uc001taj.4,p.T216N|ENST00000549405,p.T216N|ENST00000547225,p.T216N|ENST00000332156,p.T216N|uc010sum.2,p.T240N|NM_013244,p.T216N|uc001tah.4,p.T216N|uc001tal.4,p.T216N|ENST00000604798,p.T216N|ENST00000393205,p.T245N|ENST00000548651,p.T216N|uc001tai.4,p.T216N	protein_coding, processed_transcript	uc010sum.2	nonsynonymous SNV	exon6	c.C719A	p.T240N	VDYAFLLNFCANTSDYYVMLEDDVR	VDYAFLLNFCANNSDYYVMLEDDVR	3.0	5.0	-	-	4213_12:86373857-86373857 G>T_VDYAFLLNFCANNSDYYVMLEDDVR	0.0
11:133805605-133805605 G>A	0.0	4245	COLORECTAL	-	-	-	-	IGSF9B	ENST00000321016,p.R292W|NM_001277285,p.R292W|uc001qgy.1,p.R134W|ENST00000533871,p.R292W|uc031qfh.1,p.R292W	protein_coding	uc031qfh.1	nonsynonymous SNV	exon7	c.C874T	p.R292W	VRILIDGTLIIFRVKPEDSGKYTCV	VRILIDGTLIIFWVKPEDSGKYTCV	3.0	7.0	-	-	4245_11:133805605-133805605 G>A_VRILIDGTLIIFWVKPEDSGKYTCV	0.0
18:34340653-34340653 A>G	0.0	4245	COLORECTAL	-	-	-	-	FHOD3	NM_001281740,p.E1511G|uc021uiv.1,p.E1511G|ENST00000359247,p.E1311G|NM_025135,p.E1328G|ENST00000445677,p.E1290G|ENST00000592128,p.E307G|ENST00000590592,p.E1511G|ENST00000591635,p.E524G|ENST00000257209,p.E1328G|uc002kzs.1,p.E1328G|NM_001281739,p.E1311G|uc002kzt.1,p.E1311G|uc010dmz.1,p.E1043G	retained_intron, protein_coding, processed_transcript	uc021uiv.1	nonsynonymous SNV	exon27	c.A4532G	p.E1511G	QGLSYAEDAAEHENMKAVLKTSSPS	QGLSYAEDAAEHGNMKAVLKTSSPS	6.0	4.0	-	-	4245_18:34340653-34340653 A>G_QGLSYAEDAAEHGNMKAVLKTSSPS	0.0
6:81053384-81053384 G>A	1.0	4155	MELANOMA	-	-	-	-	BCKDHB	NM_000056,p.E348K|uc003pje.2,p.E348K|ENST00000320393,p.E348K|NM_183050,p.E348K|uc003pjd.2,p.E348K|ENST00000356489,p.E348K	protein_coding, processed_transcript	uc003pje.2	nonsynonymous SNV	exon10	c.G1042A	p.E348K	GFASEISSTVQEECFLNLEAPISRV	GFASEISSTVQEKCFLNLEAPISRV	5.0	7.0	-	-	4155_6:81053384-81053384 G>A_GFASEISSTVQEKCFLNLEAPISRV	0.0
12:7289434-7289434 C>T	0.0	3903	MELANOMA	-	-	-	-	CLSTN3	ENST00000537408,p.T325I|NM_014718,p.T313I|ENST00000266546,p.T313I|uc001qss.3,p.T325I|uc001qsr.3,p.T313I	retained_intron, protein_coding, processed_transcript	uc001qss.3	nonsynonymous SNV	exon6	c.C974T	p.T325I	SERALRKLCGAATGEVDLLPMPGPN	SERALRKLCGAAIGEVDLLPMPGPN	7.0	2.0	-	-	3903_12:7289434-7289434 C>T_SERALRKLCGAAIGEVDLLPMPGPN	0.0
2:86270117-86270117 G>A	1.0	4301	MELANOMA	-	-	ID=COSM1326933;OCCURENCE=1(ovary)	-	POLR1A	NM_015425,p.R1113C|uc002sqs.3,p.R1113C|ENST00000409681,p.R1113C|uc002sqt.1,p.R136C|ENST00000263857,p.R1113C|uc010ytb.2,p.R479C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ytb.2	nonsynonymous SNV	exon10	c.C1435T	p.R479C	KALKLESENRNGRSPGTQEMLRMWY	KALKLESENRNGCSPGTQEMLRMWY	7.0	9.0	-	-	4301_2:86270117-86270117 G>A_KALKLESENRNGCSPGTQEMLRMWY	0.0
12:25055897-25055897 G>A	0.0	4238	COLORECTAL	-	-	-	-	BCAT1	ENST00000539282,p.A9V|uc010six.2,p.A9V|NM_001178093,p.A9V	protein_coding, processed_transcript	uc010six.2	nonsynonymous SNV	exon1	c.C26T	p.A9V	MASPLRSAAALARQDCSNGCS	MASPLRSAVALARQDCSNGCS	2.0	5.0	-	-	4238_12:25055897-25055897 G>A_MASPLRSAVALARQDCSNGCS	0.0
9:106889711-106889711 G>C	1.0	4186	BREAST	-	-	-	-	SMC2	uc011lvl.2,p.D914H|ENST00000374793,p.D914H|ENST00000374787,p.D914H|uc004bbw.3,p.D914H|uc004bbv.3,p.D914H|uc004bbx.3,p.D914H|NM_001265602,p.D914H|NM_006444,p.D914H|ENST00000303219,p.D914H|ENST00000286398,p.D914H|NM_001042551,p.D914H|NM_001042550,p.D914H	protein_coding, nonsense_mediated_decay	uc011lvl.2	nonsynonymous SNV	exon20	c.G2740C	p.D914H	QNNDSQLKIKELDHNISKHKREAED	QNNDSQLKIKELHHNISKHKREAED	6.0	5.0	-	-	4186_9:106889711-106889711 G>C_QNNDSQLKIKELHHNISKHKREAED	0.0
22:18314630-18314630 C>A	1.0	4126	NSCLC	-	-	-	-	MICAL3	ENST00000441493,p.E1015D|uc002zng.4,p.E1015D|NM_015241,p.E1015D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002zng.4	nonsynonymous SNV	exon21	c.G3045T	p.E1015D	EEEEEDYDEEEEESSEAGNQRLQQV	EEEEEDYDEEEEDSSEAGNQRLQQV	6.0	9.0	-	-	4126_22:18314630-18314630 C>A_EEEEEDYDEEEEDSSEAGNQRLQQV	0.0
20:3103013-3103013 C>G	1.0	4240	BREAST	-	-	-	-	UBOX5	NM_014948,p.R91T|uc002why.2,p.R91T|ENST00000217173,p.R91T|ENST00000348031,p.R91T|NM_001267584,p.R91T|uc002whx.4,p.R91T|NM_199415,p.R91T|uc002whw.4,p.R91T	protein_coding	uc002why.2	nonsynonymous SNV	exon3	c.G272C	p.R91T	TGLEMYTSASSSRVSWNTPQCRTLG	TGLEMYTSASSSTVSWNTPQCRTLG	7.0	7.0	-	-	4240_20:3103013-3103013 C>G_TGLEMYTSASSSTVSWNTPQCRTLG	0.0
8:21980025-21980025 G>A	1.0	3795	MELANOMA	-	-	-	-	HR	NM_005144,p.P701L|uc003xat.3,p.P701L|ENST00000312841,p.P701L|uc003xas.3,p.P701L|ENST00000381418,p.P701L|NM_018411,p.P701L	retained_intron, protein_coding, processed_transcript	uc003xat.3	nonsynonymous SNV	exon8	c.C2102T	p.P701L	HCPCQADARVWAPGDAGQQKESTQK	HCPCQADARVWALGDAGQQKESTQK	8.0	4.0	-	-	3795_8:21980025-21980025 G>A_HCPCQADARVWALGDAGQQKESTQK	0.0
20:61430984-61430984 C>A	1.0	4196	COLORECTAL	-	-	-	-	MRGBP	ENST00000370487,p.R202S|NM_018270,p.R202S|uc002ydi.3,p.R202S	protein_coding	uc002ydi.3	nonsynonymous SNV	exon5	c.C604A	p.R202S	NSNPSSPSAAKRRRT	NSNPSSPSAAKRSRT	7.0	9.0	-	-	4196_20:61430984-61430984 C>A_NSNPSSPSAAKRSRT	0.0
15:85326298-85326298 A>G	1.0	4258	ENDOMETRIAL	-	-	-	-	ZNF592	ENST00000560079,p.K131R|NM_014630,p.K131R|ENST00000559607,p.K131R|uc002bld.3,p.K131R|ENST00000299927,p.K131R	protein_coding, nonsense_mediated_decay	uc002bld.3	nonsynonymous SNV	exon4	c.A392G	p.K131R	SARSFPGKLEPPKSEPLPTFNQFSP	SARSFPGKLEPPRSEPLPTFNQFSP	7.0	4.0	-	-	4258_15:85326298-85326298 A>G_SARSFPGKLEPPRSEPLPTFNQFSP	0.0
3:51677977-51677977 C>T	1.0	3678	MELANOMA	-	-	-	-	RAD54L2	uc011bdt.2,p.L813F|uc003dbj.3,p.L139F|uc003dbh.3,p.L402F|NM_015106,p.L813F|ENST00000296477,p.L507F|uc011bdu.2,p.L507F|ENST00000409535,p.L813F	retained_intron, protein_coding	uc011bdu.2	nonsynonymous SNV	exon11	c.C1519T	p.L507F	FNDPSNLTTWLFLLSTRAGCLGVNL	FNDPSNLTTWLFFLSTRAGCLGVNL	7.0	3.0	-	-	3678_3:51677977-51677977 C>T_FNDPSNLTTWLFFLSTRAGCLGVNL	0.0
11:7960263-7960263 C>T	0.0	2591	MELANOMA	-	-	-	-	OR10A3	uc010rbi.2,p.E269K|ENST00000360759,p.E269K|NM_001003745,p.E269K	protein_coding	uc010rbi.2	nonsynonymous SNV	exon1	c.G805A	p.E269K	MTYLQPKSGYSPETKKLISLAYTLL	MTYLQPKSGYSPKTKKLISLAYTLL	1.0	9.0	-	-	2591_11:7960263-7960263 C>T_MTYLQPKSGYSPKTKKLISLAYTLL	0.0
12:120241121-120241121 G>A	1.0	3713	MELANOMA	-	-	-	-	CIT	NM_001206999,p.S395L|NM_007174,p.S395L|ENST00000392521,p.S395L|ENST00000261833,p.S395L|uc001txj.2,p.S395L|uc001txi.2,p.S395L	retained_intron, protein_coding, processed_transcript	uc001txj.2	nonsynonymous SNV	exon10	c.C1184T	p.S395L	DDTSNFDEPEKNSWVSSSPCQLSPS	DDTSNFDEPEKNLWVSSSPCQLSPS	3.0	8.0	-	-	3713_12:120241121-120241121 G>A_DDTSNFDEPEKNLWVSSSPCQLSPS	0.0
3:105377882-105377882 C>T	1.0	3713	MELANOMA	-	-	-	1	CBLB	uc003dwc.3,p.E961K|ENST00000264122,p.E961K|ENST00000407712,p.E176K|uc011bhi.2,p.E939K|ENST00000394027,p.E939K|NM_170662,p.E961K|uc003dwa.3,p.E176K|ENST00000394030,p.E300K	retained_intron, protein_coding	uc011bhi.2	nonsynonymous SNV	exon18	c.G2815A	p.E939K	VKRALEIAQNNVEVARSILREFAFP	VKRALEIAQNNVKVARSILREFAFP	8.0	3.0	-	-	3713_3:105377882-105377882 C>T_VKRALEIAQNNVKVARSILREFAFP	0.0
1:146672753-146672753 C>G	1.0	4237	NSCLC	-	-	-	-	FMO5	NM_001144829,p.W388C|uc001eph.4,p.W388C|ENST00000254090,p.W388C|uc001epi.2,p.W388C|NM_001461,p.W388C|ENST00000441068,p.W388C	protein_coding, processed_transcript, nonsense_mediated_decay	uc001epi.2	nonsynonymous SNV	exon7	c.G1164C	p.W388C	GAIMPISELQGRWATQVFKGLKTLP	GAIMPISELQGRCATQVFKGLKTLP	8.0	1.0	-	-	4237_1:146672753-146672753 C>G_GAIMPISELQGRCATQVFKGLKTLP	0.0
12:49444738-49444738 G>A	1.0	4189	MELANOMA	-	-	-	1	KMT2D	NM_003482,p.P910S|uc001rta.4,p.P910S|ENST00000301067,p.P910S	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon10	c.C2728T	p.P910S	PALSEPGEPPLSPLPEELPLSPSGE	PALSEPGEPPLSSLPEELPLSPSGE	8.0	7.0	-	-	4189_12:49444738-49444738 G>A_PALSEPGEPPLSSLPEELPLSPSGE	0.0
6:25915765-25915765 G>C	0.0	4158	COLORECTAL	-	-	-	-	SLC17A2	NM_001286123,p.D391E|uc011dkb.2,p.D391E|ENST00000265425,p.D391E|ENST00000377850,p.D391E	protein_coding	uc011dkb.2	nonsynonymous SNV	exon9	c.C1173G	p.D391E	LLILIPGTSNLCDSGFIINTLDIAP	LLILIPGTSNLCESGFIINTLDIAP	1.0	9.0	-	-	4158_6:25915765-25915765 G>C_LLILIPGTSNLCESGFIINTLDIAP	0.0
19:55773981-55773981 G>A	1.0	4180	BREAST	-	-	-	-	HSPBP1	ENST00000433386,p.R359W|uc002qjx.3,p.R405W|NM_001297600,p.R405W|ENST00000376343,p.R257W|uc002qkd.3,p.R359W|ENST00000255631,p.R359W|NM_012267,p.R359W|uc002qkc.3,p.R359W|NM_001130106,p.R359W|ENST00000587922,p.R359W	protein_coding	uc002qkd.3	nonsynonymous SNV	exon9	c.C1075T	p.R359W	TCFSSPADDSMDR	TCFSSPADDSMDW	9.0	8.0	-	-	4180_19:55773981-55773981 G>A_TCFSSPADDSMDW	0.0
9:139101101-139101101 G>A	1.0	4071	COLORECTAL	0.0037	-	-	-	QSOX2	ENST00000358701,p.R524W|uc010nbi.2,p.R524W|NM_181701,p.R524W	protein_coding	uc010nbi.2	nonsynonymous SNV	exon12	c.C1570T	p.R524W	NGRLAGHLSEDPRFPKLQWPTPDLC	NGRLAGHLSEDPWFPKLQWPTPDLC	5.0	5.0	CD8	-	4071_9:139101101-139101101 G>A_NGRLAGHLSEDPWFPKLQWPTPDLC	2.0
6:157505561-157505561 C>T	1.0	3879	MELANOMA	-	-	-	1	ARID1B	uc003qqo.3,p.P1181L|ENST00000367148,p.P1221L|NM_017519,p.P1168L|ENST00000350026,p.P1168L|ENST00000275248,p.P1163L|uc003qqn.3,p.P1221L|ENST00000414678,p.P690L|uc003qqp.3,p.P1168L|ENST00000346085,p.P1181L|NM_020732,p.P1181L	retained_intron, protein_coding, processed_transcript	uc003qqp.3	nonsynonymous SNV	exon12	c.C3503T	p.P1168L	TGDTKKQPKLQPPSPANSGSLQGPQ	TGDTKKQPKLQPLSPANSGSLQGPQ	9.0	2.0	-	-	3879_6:157505561-157505561 C>T_TGDTKKQPKLQPLSPANSGSLQGPQ	0.0
12:121598721-121598721 C>T	0.0	4329	COLORECTAL	-	-	ID=COSM1359427;OCCURENCE=1(large_intestine)	-	P2RX7	NM_002562,p.T127M|uc001tzn.3,p.T37M|ENST00000377162,p.T127M|ENST00000541564,p.T127M|ENST00000261826,p.T127M|ENST00000535250,p.T37M|uc001tzm.3,p.T127M|ENST00000546057,p.T127M|ENST00000535600,p.T127M	retained_intron, protein_coding, nonsense_mediated_decay	uc001tzn.3	nonsynonymous SNV	exon5	c.C110T	p.T37M	EQRLCPEYPTRRTLCSSDRGCKKGW	EQRLCPEYPTRRMLCSSDRGCKKGW	5.0	3.0	-	-	4329_12:121598721-121598721 C>T_EQRLCPEYPTRRMLCSSDRGCKKGW	0.0
5:86672380-86672380 G>C	1.0	4240	BREAST	-	-	-	-	RASA1	ENST00000274376,p.E728Q|uc003kix.3,p.E551Q|uc011ctv.2,p.E561Q|uc010jaw.3,p.E550Q|uc003kiw.3,p.E728Q|NM_022650,p.E551Q|ENST00000512763,p.E561Q|uc011ctw.2,p.E562Q|ENST00000506290,p.E562Q|ENST00000456692,p.E551Q|NM_002890,p.E728Q	retained_intron, protein_coding, nonsense_mediated_decay	uc011ctw.2	nonsynonymous SNV	exon17	c.G1684C	p.E562Q	KIMPEEEYSEFKELILQKELHVVYA	KIMPEEEYSEFKQLILQKELHVVYA	8.0	9.0	-	-	4240_5:86672380-86672380 G>C_KIMPEEEYSEFKQLILQKELHVVYA	0.0
3:81586139-81586139 G>A	1.0	3713	MELANOMA	0.0005	-	-	-	GBE1	uc021xax.1,p.R535C|ENST00000429644,p.R576C|ENST00000489715,p.R535C|uc021xav.1,p.R576C|NM_000158,p.R576C	retained_intron, protein_coding, processed_transcript	uc021xax.1	nonsynonymous SNV	exon13	c.C1603T	p.R535C	RRQFHLTDDDLLRYKFLNNFDRDMN	RRQFHLTDDDLLCYKFLNNFDRDMN	4.0	2.0	-	-	3713_3:81586139-81586139 G>A_RRQFHLTDDDLLCYKFLNNFDRDMN	0.0
19:57089220-57089220 C>T	1.0	2369	MELANOMA	-	-	-	-	ZNF470	ENST00000330619,p.H475Y|ENST00000391709,p.H475Y|NM_001001668,p.H475Y|uc002qnl.4,p.H475Y	protein_coding, processed_transcript	uc002qnl.4	nonsynonymous SNV	exon6	c.C1423T	p.H475Y	SHRGSLTLHQRVHTGEKPYECKECG	SHRGSLTLHQRVYTGEKPYECKECG	6.0	8.0	-	-	2369_19:57089220-57089220 C>T_SHRGSLTLHQRVYTGEKPYECKECG	0.0
10:92508612-92508612 T>C	1.0	3713	MELANOMA	-	-	-	-	HTR7	NM_019859,p.R427G|uc001kha.3,p.R427G|ENST00000336152,p.R427G	protein_coding	uc001kha.3	nonsynonymous SNV	exon2	c.A1279G	p.R427G	MHEALKLAERPERPEFVLRACTRRV	MHEALKLAERPEGPEFVLRACTRRV	2.0	7.0	-	-	3713_10:92508612-92508612 T>C_MHEALKLAERPEGPEFVLRACTRRV	0.0
10:46967469-46967469 C>T	1.0	4287	COLORECTAL	-	-	ID=COSM1347897,COSM1347898,COSM1347896;OCCURENCE=1(large_intestine)	-	SYT15	ENST00000512997,p.R87H|uc001jdz.2,p.R203H|ENST00000374325,p.R203H|ENST00000374321,p.R203H|uc001jea.3,p.R203H|uc001jeb.3,p.R81H|NM_181519,p.R203H|ENST00000503753,p.R203H|NM_031912,p.R203H|ENST00000374323,p.R256H	protein_coding, processed_transcript	uc001jeb.3	nonsynonymous SNV	exon3	c.G242A	p.R81H	PDERRFLQSKTKRKTSNPQFDEHFI	PDERRFLQSKTKHKTSNPQFDEHFI	4.0	9.0	-	-	4287_10:46967469-46967469 C>T_PDERRFLQSKTKHKTSNPQFDEHFI	0.0
1:2252842-2252842 C>T	0.0	4301	MELANOMA	-	-	-	-	MORN1	uc001ajb.1,p.E492K|ENST00000378531,p.E492K|NM_024848,p.E492K	retained_intron, protein_coding	uc001ajb.1	nonsynonymous SNV	exon14	c.G1474A	p.E492K	SSSWQAAHSCTPEPPAPR	SSSWQAAHSCTPKPPAPR	7.0	3.0	-	-	4301_1:2252842-2252842 C>T_SSSWQAAHSCTPKPPAPR	0.0
8:41166361-41166361 G>C	0.0	4129	NSCLC	-	-	-	-	SFRP1	NM_003012,p.H106Q|ENST00000220772,p.H106Q|uc003xnt.3,p.H106Q	protein_coding	uc003xnt.3	nonsynonymous SNV	exon1	c.C318G	p.H106Q	ASSWVPLLNKNCHAGTQVFLCSLFA	ASSWVPLLNKNCQAGTQVFLCSLFA	3.0	7.0	-	-	4129_8:41166361-41166361 G>C_ASSWVPLLNKNCQAGTQVFLCSLFA	0.0
X:12938926-12938926 A>C	0.0	4266	COLORECTAL	-	-	-	-	TLR8	NM_138636,p.L589F|ENST00000218032,p.L589F|NM_016610,p.L607F|uc004cvd.3,p.L607F|uc004cve.3,p.L589F|ENST00000311912,p.L607F	protein_coding	uc004cve.3	nonsynonymous SNV	exon2	c.A1767C	p.L589F	LEFIQNFTNLKVLNLSHNNIYTLTD	LEFIQNFTNLKVFNLSHNNIYTLTD	4.0	7.0	-	-	4266_X:12938926-12938926 A>C_LEFIQNFTNLKVFNLSHNNIYTLTD	0.0
17:64731637-64731637 G>A	1.0	3678	MELANOMA	-	-	ID=COSM3820296;OCCURENCE=1(breast)	-	PRKCA	uc002jfp.1,p.E363K|ENST00000413366,p.E363K|uc002jfo.1,p.E234K|NM_002737,p.E363K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002jfp.1	nonsynonymous SNV	exon10	c.G1087A	p.E363K	GKVMLADRKGTEELYAIKILKKDVV	GKVMLADRKGTEKLYAIKILKKDVV	6.0	6.0	-	-	3678_17:64731637-64731637 G>A_GKVMLADRKGTEKLYAIKILKKDVV	0.0
6:29054625-29054625 A>C	0.0	4326	BREAST	-	-	-	-	OR2B3	NM_001005226,p.V134G|ENST00000377173,p.V134G|uc003nlx.3,p.V134G	protein_coding	uc003nlx.3	nonsynonymous SNV	exon1	c.T401G	p.V134G	RYVAVCRPLHYVVIMNYWFCLRMAA	RYVAVCRPLHYVGIMNYWFCLRMAA	1.0	5.0	-	-	4326_6:29054625-29054625 A>C_RYVAVCRPLHYVGIMNYWFCLRMAA	0.0
6:52103567-52103567 C>T	0.0	4095	COLORECTAL	-	-	-	-	IL17F	ENST00000336123,p.R72H|uc003pal.1,p.R18H|uc003pam.1,p.R72H|NM_052872,p.R72H	retained_intron, protein_coding	uc003pam.1	nonsynonymous SNV	exon2	c.G215A	p.R72H	GIINENQRVSMSRNIESRSTSPWNY	GIINENQRVSMSHNIESRSTSPWNY	3.0	7.0	-	-	4095_6:52103567-52103567 C>T_GIINENQRVSMSHNIESRSTSPWNY	0.0
3:9027277-9027277 C>T	0.0	4186	BREAST	-	-	-	2	SRGAP3	NM_014850,p.V1076M|NM_001033117,p.V1052M|ENST00000360413,p.V1052M|uc003brf.2,p.V1076M|uc003brg.2,p.V1052M|ENST00000383836,p.V1076M	retained_intron, protein_coding, processed_transcript	uc003brg.2	nonsynonymous SNV	exon22	c.G3154A	p.V1052M	VQHRSSSSSSSGVGSPAVTPTEKMF	VQHRSSSSSSSGMGSPAVTPTEKMF	4.0	8.0	-	-	4186_3:9027277-9027277 C>T_VQHRSSSSSSSGMGSPAVTPTEKMF	0.0
14:51464776-51464776 G>A	0.0	4346	COLORECTAL	-	-	-	-	TRIM9	NM_015163,p.T532M|uc001wyx.4,p.T532M|ENST00000298355,p.T532M	retained_intron, protein_coding, processed_transcript	uc001wyx.4	nonsynonymous SNV	exon7	c.C1595T	p.T532M	GVSPYSKTLVLQTSEVAWFAFDPGS	GVSPYSKTLVLQMSEVAWFAFDPGS	3.0	1.0	-	-	4346_14:51464776-51464776 G>A_GVSPYSKTLVLQMSEVAWFAFDPGS	0.0
9:135271871-135271871 A>C	1.0	4345	COLORECTAL	-	-	-	-	TTF1	uc004cbl.3,p.L602R|NM_007344,p.L602R|NM_001205296,p.L87R|ENST00000334270,p.L602R|uc004cbm.3,p.L87R	protein_coding, processed_transcript	uc004cbm.3	nonsynonymous SNV	exon4	c.T260G	p.L87R	LHIGRNIARPWKLIYYRAKKMFDVN	LHIGRNIARPWKRIYYRAKKMFDVN	5.0	3.0	-	-	4345_9:135271871-135271871 A>C_LHIGRNIARPWKRIYYRAKKMFDVN	0.0
19:36398149-36398149 G>A	0.0	4213	COLORECTAL	-	-	-	-	TYROBP	NM_003332,p.R83C|uc021uta.1,p.R72C|NM_001173514,p.R72C|uc002ocm.3,p.R83C|ENST00000544690,p.R72C|ENST00000262629,p.R83C	retained_intron, protein_coding, nonsense_mediated_decay	uc021uta.1	nonsynonymous SNV	exon3	c.C214T	p.R72C	GRGAAEAATRKQRITETESPYQELQ	GRGAAEAATRKQCITETESPYQELQ	10.0	8.0	-	-	4213_19:36398149-36398149 G>A_GRGAAEAATRKQCITETESPYQELQ	0.0
2:220404548-220404548 G>A	1.0	3784	MELANOMA	-	-	-	-	CHPF	uc002vmc.4,p.R629C|ENST00000243776,p.R629C|NM_001195731,p.R467C|ENST00000535926,p.R467C|NM_024536,p.R629C|uc010zlh.2,p.R467C	protein_coding	uc010zlh.2	nonsynonymous SNV	exon4	c.C1399T	p.R467C	DTVLTPDFLNRCRMHAISGWQAFFP	DTVLTPDFLNRCCMHAISGWQAFFP	9.0	2.0	-	-	3784_2:220404548-220404548 G>A_DTVLTPDFLNRCCMHAISGWQAFFP	0.0
7:158738280-158738280 C>T	1.0	3713	MELANOMA	-	-	-	-	WDR60	uc010lqw.3,p.A636V|ENST00000454771,p.A134V|uc003woe.4,p.A1004V|ENST00000407559,p.A1004V|NM_018051,p.A1004V	retained_intron, protein_coding, nonsense_mediated_decay	uc010lqw.3	nonsynonymous SNV	exon20	c.C1907T	p.A636V	VAKQQVSPNRLVAMAAVGEPEKAGG	VAKQQVSPNRLVVMAAVGEPEKAGG	7.0	8.0	-	-	3713_7:158738280-158738280 C>T_VAKQQVSPNRLVVMAAVGEPEKAGG	0.0
20:13029636-13029636 C>T	0.0	3466	MELANOMA	-	-	-	-	SPTLC3	ENST00000399002,p.S54L|uc002woc.3,p.S54L|uc002wod.1,p.S54L|ENST00000434210,p.S54L|ENST00000378194,p.S54L|ENST00000450297,p.S27L|NM_018327,p.S54L	protein_coding, processed_transcript	uc002wod.1	nonsynonymous SNV	exon2	c.C161T	p.S54L	GKPHFYDKLIVESFEEAPLHVMVFT	GKPHFYDKLIVELFEEAPLHVMVFT	4.0	5.0	-	-	3466_20:13029636-13029636 C>T_GKPHFYDKLIVELFEEAPLHVMVFT	0.0
14:96730546-96730546 G>A	0.0	3903	MELANOMA	-	-	-	-	BDKRB1	uc001yfh.3,p.R176Q|ENST00000216629,p.R176Q|ENST00000553356,p.R176Q|NM_000710,p.R176Q|uc021sbj.1,p.R176Q	protein_coding, processed_transcript	uc021sbj.1	nonsynonymous SNV	exon1	c.G527A	p.R176Q	VGGLLSIPTFLLRSIQAVPDLNITA	VGGLLSIPTFLLQSIQAVPDLNITA	1.0	8.0	-	-	3903_14:96730546-96730546 G>A_VGGLLSIPTFLLQSIQAVPDLNITA	0.0
9:140110812-140110812 G>A	1.0	4278	COLORECTAL	-	-	-	-	NDOR1	ENST00000458322,p.A573T|ENST00000344894,p.A580T|NM_001144028,p.A573T|NM_014434,p.A580T|uc011mes.2,p.A573T|ENST00000371521,p.A589T|uc004clw.3,p.A580T|NM_001144026,p.A589T|uc004clx.3,p.A589T	protein_coding	uc011mes.2	nonsynonymous SNV	exon14	c.G1717A	p.A573T	QEEGGLCSPDAAAYLARLQQTRRFQ	QEEGGLCSPDAATYLARLQQTRRFQ	6.0	9.0	-	-	4278_9:140110812-140110812 G>A_QEEGGLCSPDAATYLARLQQTRRFQ	0.0
20:3654065-3654065 G>T	0.0	4284	COLORECTAL	-	-	-	-	ADAM33	NM_001282447,p.P357T|NM_025220,p.P357T|uc002wir.1,p.P357T|ENST00000350009,p.P357T|ENST00000356518,p.P357T|NM_153202,p.P357T|uc010zqg.1,p.P369T|uc002wit.3,p.P357T|uc002wiu.3,p.P357T|ENST00000379861,p.P357T	protein_coding, processed_transcript	uc010zqg.1	nonsynonymous SNV	exon11	c.C1105A	p.P369T	HEIGHSLGLSHDPDGCCVEAAAESG	HEIGHSLGLSHDTDGCCVEAAAESG	3.0	9.0	-	-	4284_20:3654065-3654065 G>T_HEIGHSLGLSHDTDGCCVEAAAESG	0.0
3:178916924-178916924 C>T	1.0	4320	COLORECTAL	-	-	ID=COSM163485,COSM1484857;OCCURENCE=1(NS),1(breast)	1	PIK3CA	NM_006218,p.P104L|ENST00000468036,p.P104L|uc003fjk.3,p.P104L|ENST00000263967,p.P104L	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon2	c.C311T	p.P104L	LRLFQPFLKVIEPVGNREEKILNRE	LRLFQPFLKVIELVGNREEKILNRE	7.0	10.0	-	-	4320_3:178916924-178916924 C>T_LRLFQPFLKVIELVGNREEKILNRE	0.0
13:35615209-35615209 G>A	1.0	4000	MELANOMA	-	-	-	2	NBEA	ENST00000379939,p.R145Q|ENST00000310336,p.R145Q|uc021ric.1,p.R145Q|NM_015678,p.R145Q|ENST00000400445,p.R145Q|uc021rid.1,p.R145Q|ENST00000540320,p.R145Q	protein_coding, processed_transcript	uc021rid.1	nonsynonymous SNV	exon2	c.G434A	p.R145Q	QAEIWSMFTAILRKSVRNLQTSTEV	QAEIWSMFTAILQKSVRNLQTSTEV	6.0	4.0	-	-	4000_13:35615209-35615209 G>A_QAEIWSMFTAILQKSVRNLQTSTEV	0.0
9:95480988-95480988 G>A	1.0	4335	COLORECTAL	-	-	-	-	BICD2	NM_001003800,p.R647C|ENST00000375512,p.R647C|ENST00000356884,p.R647C|uc004aso.1,p.R647C|uc004asp.1,p.R647C|NM_015250,p.R647C	protein_coding	uc004asp.1	nonsynonymous SNV	exon5	c.C1939T	p.R647C	RDQIKHLQAAVDRTTELSRQRIASQ	RDQIKHLQAAVDCTTELSRQRIASQ	6.0	10.0	-	-	4335_9:95480988-95480988 G>A_RDQIKHLQAAVDCTTELSRQRIASQ	0.0
X:49019235-49019235 C>T	0.0	3775	CERVICAL	-	-	-	-	MAGIX	uc010nio.1,p.P3L|uc010nin.1,p.P3L|ENST00000425661,p.P3L|uc004dmt.2,p.P3L|ENST00000412696,p.P3L	protein_coding, processed_transcript	uc010nio.1	nonsynonymous SNV	exon1	c.C8T	p.P3L	MEPRTGGAANPKGSR	MELRTGGAANPKGSR	4.0	5.0	-	-	3775_X:49019235-49019235 C>T_MELRTGGAANPKGSR	0.0
13:109562389-109562389 G>T	0.0	4259	COLORECTAL	-	-	-	-	MYO16	uc010agk.2,p.V606F|ENST00000457511,p.V96F|uc001vqu.1,p.V384F|ENST00000251041,p.V584F|uc001vqt.1,p.V584F|ENST00000356711,p.V584F|ENST00000357550,p.V584F|NM_001198950,p.V606F|uc010tjh.1,p.V96F|NM_015011,p.V584F	protein_coding, processed_transcript	uc010tjh.1	nonsynonymous SNV	exon4	c.G286T	p.V96F	RIYTYLLEKSRLVSQPLGQSNFLIF	RIYTYLLEKSRLFSQPLGQSNFLIF	2.0	5.0	-	-	4259_13:109562389-109562389 G>T_RIYTYLLEKSRLFSQPLGQSNFLIF	0.0
3:113785082-113785082 C>T	1.0	4326	BREAST	-	-	-	-	QTRTD1	uc003eay.4,p.H70Y|ENST00000482307,p.H70Y|NM_001256835,p.H82Y|uc003eaz.4,p.H82Y|ENST00000472599,p.H84Y|ENST00000281273,p.H70Y|NM_024638,p.H70Y|ENST00000485050,p.H82Y	retained_intron, protein_coding, processed_transcript	uc003eaz.4	nonsynonymous SNV	exon3	c.C244T	p.H82Y	AMAQLTLSSLAEHHEVLTEYKEGVG	AMAQLTLSSLAEYHEVLTEYKEGVG	9.0	4.0	-	-	4326_3:113785082-113785082 C>T_AMAQLTLSSLAEYHEVLTEYKEGVG	0.0
22:20073722-20073722 C>T	1.0	3879	MELANOMA	-	-	-	2	DGCR8	NM_022720,p.S79F|uc002zri.3,p.S79F|NM_001190326,p.S79F|uc010grz.3,p.S79F|ENST00000457069,p.S79F|ENST00000351989,p.S79F|ENST00000407755,p.S79F|ENST00000383024,p.S79F	retained_intron, protein_coding	uc010grz.3	nonsynonymous SNV	exon2	c.C236T	p.S79F	FNFYGASLLSKGSFSKGRLLIDPNC	FNFYGASLLSKGFFSKGRLLIDPNC	8.0	5.0	-	-	3879_22:20073722-20073722 C>T_FNFYGASLLSKGFFSKGRLLIDPNC	0.0
22:25623887-25623887 C>T	0.0	4213	COLORECTAL	0.0005	-	-	-	CRYBB2	NM_000496,p.R81C|uc003abp.1,p.R81C|ENST00000398215,p.R81C	protein_coding	uc003abp.1	nonsynonymous SNV	exon4	c.C241T	p.R81C	GEQFVFEKGEYPRWDSWTSSRRTDS	GEQFVFEKGEYPCWDSWTSSRRTDS	5.0	10.0	-	-	4213_22:25623887-25623887 C>T_GEQFVFEKGEYPCWDSWTSSRRTDS	0.0
12:56827705-56827705 C>T	1.0	3713	MELANOMA	-	-	-	-	TIMELESS	uc001slf.2,p.V35M|ENST00000229201,p.V35M|ENST00000553532,p.V35M|uc001slg.2,p.V35M|NM_003920,p.V35M|ENST00000554616,p.V35M	retained_intron, protein_coding	uc001slg.2	nonsynonymous SNV	exon3	c.G103A	p.V35M	DTYHKEPDCLESVKDLIRYLRHEDE	DTYHKEPDCLESMKDLIRYLRHEDE	3.0	7.0	-	-	3713_12:56827705-56827705 C>T_DTYHKEPDCLESMKDLIRYLRHEDE	0.0
5:148612798-148612798 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	ABLIM3	uc003lqc.1,p.R275W|NM_014945,p.R275W|ENST00000356541,p.R275W|ENST00000506113,p.R275W|ENST00000508983,p.R275W|uc003lpy.2,p.R275W|uc003lqe.1,p.R275W|uc003lqd.1,p.R275W|NM_001301028,p.R275W|NM_001301015,p.R275W|ENST00000504238,p.R275W|uc003lqf.3,p.R275W|uc003lqb.3,p.R275W|uc003lpz.1,p.R275W|NM_001301018,p.R275W|ENST00000326685,p.R275W|ENST00000309868,p.R275W|uc003lqa.1,p.R283W|NM_001301027,p.R283W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lqf.3	nonsynonymous SNV	exon9	c.C823T	p.R275W	QAARAEKKLKHRRTSETSISPPGSS	QAARAEKKLKHRWTSETSISPPGSS	4.0	8.0	-	-	4258_5:148612798-148612798 C>T_QAARAEKKLKHRWTSETSISPPGSS	0.0
11:31113031-31113031 T>G	0.0	4335	COLORECTAL	-	-	-	-	DCDC5,DCDC1	ENST00000597505,p.T716P|uc009yjl.1,p.T92P|uc001msu.2,p.T335P|uc009yjk.1,p.T164P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009yjl.1	nonsynonymous SNV	exon7	c.A274C	p.T92P	ITKTGMILSRAITQGCLAIGHPIRV	ITKTGMILSRAIPQGCLAIGHPIRV	5.0	1.0	-	-	4335_11:31113031-31113031 T>G_ITKTGMILSRAIPQGCLAIGHPIRV	0.0
16:89958640-89958640 G>T	1.0	4078	GASTRIC	-	-	-	-	TCF25	ENST00000263346,p.W218C|NM_014972,p.W218C|ENST00000565196,p.W196C|ENST00000561958,p.W206C|uc002fpb.2,p.W218C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002fpb.2	nonsynonymous SNV	exon6	c.G654T	p.W218C	PRQRQRVYPKCTWLTTPKSTWPRYS	PRQRQRVYPKCTCLTTPKSTWPRYS	10.0	9.0	-	-	4078_16:89958640-89958640 G>T_PRQRQRVYPKCTCLTTPKSTWPRYS	0.0
3:39230120-39230120 A>G	0.0	4258	ENDOMETRIAL	-	-	-	-	XIRP1	uc003cji.3,p.F273L|ENST00000396251,p.F273L|uc003cjk.2,p.F273L|ENST00000340369,p.F273L|NM_194293,p.F273L|uc021wvz.1,p.F273L|NM_001198621,p.F273L	protein_coding	uc021wvz.1	nonsynonymous SNV	exon1	c.T817C	p.F273L	IQSNAVRSARWLFETRPLDAINQDP	IQSNAVRSARWLLETRPLDAINQDP	4.0	9.0	-	-	4258_3:39230120-39230120 A>G_IQSNAVRSARWLLETRPLDAINQDP	0.0
20:8717692-8717692 T>G	1.0	3713	MELANOMA	-	-	-	-	PLCB1	ENST00000378641,p.F687L|uc002wna.4,p.F687L|ENST00000338037,p.F687L|uc010zrb.1,p.F586L|uc002wnd.1,p.F264L|NM_015192,p.F687L|NM_182734,p.F687L|ENST00000378637,p.F687L|uc002wnc.1,p.F586L|uc002wnb.4,p.F687L	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zrb.1	nonsynonymous SNV	exon20	c.T1758G	p.F586L	ANTLSVKIISGQFLSDKKVGTYVEV	ANTLSVKIISGQLLSDKKVGTYVEV	1.0	9.0	-	-	3713_20:8717692-8717692 T>G_ANTLSVKIISGQLLSDKKVGTYVEV	0.0
8:101014555-101014555 G>A	0.0	4077	BILE DUCT	-	-	-	-	RGS22	ENST00000523287,p.R708W|uc003yjb.1,p.R889W|NM_015668,p.R889W|ENST00000517828,p.R204W|NM_001286692,p.R877W|uc022azf.1,p.R278W|NM_001286693,p.R708W|uc003yjc.1,p.R877W|ENST00000360863,p.R889W|uc003yja.1,p.R708W|ENST00000523437,p.R877W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022azf.1	nonsynonymous SNV	exon7	c.C832T	p.R278W	MDLMCWTDIEQFRRITYRDRNQRKA	MDLMCWTDIEQFWRITYRDRNQRKA	2.0	3.0	-	-	4077_8:101014555-101014555 G>A_MDLMCWTDIEQFWRITYRDRNQRKA	0.0
7:127991332-127991332 C>T	0.0	4213	COLORECTAL	-	-	-	-	PRRT4	ENST00000446477,p.G760R|NM_001174164,p.G760R|ENST00000435512,p.G554R|ENST00000535159,p.G760R|uc022aky.1,p.G760R	protein_coding	uc022aky.1	nonsynonymous SNV	exon6	c.G2278A	p.G760R	QGPAFEDALPGLGLYRTASLGTGGR	QGPAFEDALPGLRLYRTASLGTGGR	2.0	9.0	-	-	4213_7:127991332-127991332 C>T_QGPAFEDALPGLRLYRTASLGTGGR	0.0
1:220826691-220826691 G>A	1.0	4037	NSCLC	-	-	-	-	MARK1	uc010pun.2,p.R662H|ENST00000366918,p.R640H|NM_001286126,p.R662H|ENST00000402574,p.R527H|NM_001286128,p.R640H|uc001hmm.4,p.R640H	protein_coding, processed_transcript	uc010pun.2	nonsynonymous SNV	exon16	c.G1985A	p.R662H	TGIISKITSKFVRRSTSGEPKERDK	TGIISKITSKFVHRSTSGEPKERDK	6.0	10.0	-	-	4037_1:220826691-220826691 G>A_TGIISKITSKFVHRSTSGEPKERDK	0.0
5:140308584-140308584 G>A	0.0	4298	COLORECTAL	-	-	ID=COSM241074;OCCURENCE=1(prostate)	-	PCDHAC1	NM_031882,p.V703M|uc003lig.1,p.V703M|uc003lih.2,p.V703M|ENST00000409700,p.V703M|ENST00000253807,p.V703M|NM_018898,p.V703M	protein_coding	uc003lih.2	nonsynonymous SNV	exon1	c.G2107A	p.V703M	ISFLFLGCLLFFVCTKLHQSPGCCA	ISFLFLGCLLFFMCTKLHQSPGCCA	2.0	3.0	-	-	4298_5:140308584-140308584 G>A_ISFLFLGCLLFFMCTKLHQSPGCCA	0.0
12:40836893-40836893 G>A	0.0	3795	MELANOMA	-	-	-	-	MUC19	ENST00000425730,p.E726K	retained_intron, protein_coding, processed_transcript	ENST00000425730	nonsynonymous SNV	exon26	c.G2176A	p.E726K	CQYSFLEDYCGHENGTFRILTESVP	CQYSFLEDYCGHKNGTFRILTESVP	2.0	9.0	-	-	3795_12:40836893-40836893 G>A_CQYSFLEDYCGHKNGTFRILTESVP	0.0
12:58001393-58001393 G>C	1.0	3775	CERVICAL	-	-	-	-	DTX3	ENST00000337737,p.Q249H|ENST00000551632,p.Q252H|ENST00000550300,p.Q37H|uc001soy.1,p.Q242H|uc001sox.1,p.Q242H|NM_001286245,p.Q252H|uc001sow.1,p.Q249H|ENST00000548804,p.Q249H|ENST00000548198,p.Q249H|NM_178502,p.Q249H|NM_001286246,p.Q249H	protein_coding	uc001soy.1	nonsynonymous SNV	exon3	c.G726C	p.Q242H	TIVIQYVFPPGVQGAEHPNPGVRYP	TIVIQYVFPPGVHGAEHPNPGVRYP	8.0	7.0	-	-	3775_12:58001393-58001393 G>C_TIVIQYVFPPGVHGAEHPNPGVRYP	0.0
3:153943651-153943651 C>T	1.0	3903	MELANOMA	-	-	ID=COSM445831,COSM445832,COSM445833;OCCURENCE=1(breast)	-	ARHGEF26	uc011boh.1,p.P648S|NM_001251962,p.P648S|NM_001251963,p.P648S|NM_015595,p.P648S|ENST00000496710,p.P648S|ENST00000465093,p.P648S|uc011bog.1,p.P648S|ENST00000356448,p.P648S|uc021xgc.1,p.P648S	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xgc.1	nonsynonymous SNV	exon11	c.C1942T	p.P648S	INSQLEFKIKPFPLVSSSRWLVKRG	INSQLEFKIKPFSLVSSSRWLVKRG	5.0	9.0	-	-	3903_3:153943651-153943651 C>T_INSQLEFKIKPFSLVSSSRWLVKRG	0.0
12:75816743-75816743 G>A	0.0	4284	COLORECTAL	-	-	-	-	GLIPR1L2	uc001sxr.2,p.R215H|NM_001270396,p.R215H|ENST00000378692,p.R108H|uc001sxq.2,p.R108H|ENST00000441218,p.R150H|ENST00000550916,p.R215H	protein_coding	uc001sxr.2	nonsynonymous SNV	exon4	c.G644A	p.R215H	YEPGIFCTRCGRRDKCTDFLCSNAD	YEPGIFCTRCGRHDKCTDFLCSNAD	4.0	7.0	-	-	4284_12:75816743-75816743 G>A_YEPGIFCTRCGRHDKCTDFLCSNAD	0.0
12:122359536-122359536 C>T	0.0	4329	COLORECTAL	-	-	-	-	WDR66	uc021rfh.1,p.R109C|uc009zxk.3,p.R109C|ENST00000288912,p.R109C|NM_001178003,p.R109C|NM_144668,p.R109C|ENST00000397454,p.R109C	retained_intron, protein_coding, processed_transcript	uc021rfh.1	nonsynonymous SNV	exon2	c.C325T	p.R109C	TVEPQEVTASMIRLETQITDSQSIT	TVEPQEVTASMICLETQITDSQSIT	5.0	9.0	-	-	4329_12:122359536-122359536 C>T_TVEPQEVTASMICLETQITDSQSIT	0.0
18:77477934-77477934 G>A	0.0	3998	MELANOMA	-	-	-	-	CTDP1	NM_004715,p.G779R|ENST00000299543,p.G779R|ENST00000591598,p.G711R|ENST00000075430,p.G779R|NM_048368,p.G779R|uc002lnh.2,p.G779R|NM_001202504,p.G660R|uc021ult.1,p.G660R|uc010drd.2,p.G779R|uc002lni.2,p.G779R	retained_intron, protein_coding, processed_transcript	uc021ult.1	nonsynonymous SNV	exon10	c.G1978A	p.G660R	PGPEVRIYDSNTGKLIRTGARGPPA	PGPEVRIYDSNTRKLIRTGARGPPA	7.0	9.0	-	-	3998_18:77477934-77477934 G>A_PGPEVRIYDSNTRKLIRTGARGPPA	0.0
16:4016326-4016326 G>A	1.0	3713	MELANOMA	-	-	-	-	ADCY9	NM_001116,p.P1171L|ENST00000294016,p.P1171L|uc002cvx.3,p.P1171L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002cvx.3	nonsynonymous SNV	exon11	c.C3512T	p.P1171L	FNFKLRVGFNHGPLTAGVIGTTKLL	FNFKLRVGFNHGLLTAGVIGTTKLL	5.0	2.0	-	-	3713_16:4016326-4016326 G>A_FNFKLRVGFNHGLLTAGVIGTTKLL	0.0
2:25374825-25374825 G>A	1.0	4110	BILE DUCT	-	-	-	-	EFR3B	NM_014971,p.R745Q|ENST00000403714,p.R745Q|ENST00000405108,p.R597Q|uc010eyh.3,p.R745Q|ENST00000402191,p.R710Q|ENST00000264719,p.R580Q	protein_coding	uc010eyh.3	nonsynonymous SNV	exon21	c.G2234A	p.R745Q	SVAVEEQERERRRQVVEKFQKAPFE	SVAVEEQERERRQQVVEKFQKAPFE	3.0	10.0	-	-	4110_2:25374825-25374825 G>A_SVAVEEQERERRQQVVEKFQKAPFE	0.0
13:21563000-21563000 G>A	1.0	4155	MELANOMA	-	-	-	-	LATS2	NM_014572,p.P307S|ENST00000382592,p.P307S|uc001unr.4,p.P307S|ENST00000542899,p.P307S|uc009zzs.3,p.P307S	protein_coding, processed_transcript	uc009zzs.3	nonsynonymous SNV	exon4	c.C919T	p.P307S	GGPPGAGLAFPPPAAGLYVPHPHHK	GGPPGAGLAFPPSAAGLYVPHPHHK	5.0	4.0	-	-	4155_13:21563000-21563000 G>A_GGPPGAGLAFPPSAAGLYVPHPHHK	0.0
1:196438197-196438197 C>T	1.0	3998	MELANOMA	-	-	-	-	KCNT2	ENST00000367433,p.G129E|uc001gte.1,p.G129E|ENST00000367431,p.G129E|ENST00000294725,p.G129E|NM_001287820,p.G129E|uc001gtd.1,p.G129E|NM_001287819,p.G129E|uc009wyu.3,p.G129E|uc001gtf.1,p.G129E|NM_198503,p.G129E	protein_coding, processed_transcript	uc009wyu.3	nonsynonymous SNV	exon6	c.G386A	p.G129E	FETILLGYLSYKGNIWEQILRIPFI	FETILLGYLSYKENIWEQILRIPFI	6.0	1.0	-	-	3998_1:196438197-196438197 C>T_FETILLGYLSYKENIWEQILRIPFI	0.0
8:18490147-18490147 G>A	1.0	3998	MELANOMA	-	-	-	-	PSD3	NM_015310,p.H796Y|ENST00000440756,p.H798Y|NM_206909,p.H262Y|ENST00000286485,p.H262Y|uc003wyx.4,p.H125Y|uc003wza.3,p.H796Y|ENST00000523619,p.H731Y|uc003wyz.3,p.H97Y|uc003wyy.3,p.H262Y|ENST00000327040,p.H796Y|ENST00000428502,p.H125Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003wza.3	nonsynonymous SNV	exon11	c.C2386T	p.H796Y	AVYKSGFLARKIHADMDGKKTPRGK	AVYKSGFLARKIYADMDGKKTPRGK	10.0	9.0	-	-	3998_8:18490147-18490147 G>A_AVYKSGFLARKIYADMDGKKTPRGK	0.0
X:63411274-63411274 ->CGGGC	1.0	4316	COLORECTAL	-	-	-	1	AMER1	uc004dvo.3,p.R631fs|ENST00000403336,p.R631fs|ENST00000374869,p.R631fs|ENST00000330258,p.R631fs|NM_152424,p.R631fs|uc022byb.1,p.R631fs	protein_coding	uc022byb.1	frameshift insertion	exon1	c.1892_1893insGCCCG	p.R631fs	HGREARTREAQAREVRCRETQVRET	HGREARTREAQARPERFVVERLKSERPRPGRRSPS	6.0	9.0	-	-	4316_X:63411274-63411274 ->CGGGC_HGREARTREAQARPERFVVERLKSERPRPGRRSPS	0.0
13:39265382-39265382 G>T	0.0	3775	CERVICAL	-	-	-	-	FREM2	ENST00000280481,p.D1301Y|NM_207361,p.D1301Y|uc001uwv.3,p.D1301Y	protein_coding, processed_transcript	uc001uwv.3	nonsynonymous SNV	exon1	c.G3901T	p.D1301Y	EKTVLIIVIPVDDETPRMTINNGLE	EKTVLIIVIPVDYETPRMTINNGLE	1.0	7.0	-	-	3775_13:39265382-39265382 G>T_EKTVLIIVIPVDYETPRMTINNGLE	0.0
11:60704359-60704359 A>G	1.0	3903	MELANOMA	-	-	-	-	TMEM132A	ENST00000453848,p.R1018G|NM_017870,p.R1019G|NM_178031,p.R1018G|uc001nqi.3,p.R1019G|ENST00000005286,p.R1019G|uc001nqj.3,p.R1018G	retained_intron, protein_coding, processed_transcript	uc001nqj.3	nonsynonymous SNV	exon11	c.A3052G	p.R1018G	LKDPEELRNYMERIRGSS	LKDPEELRNYMEGIRGSS	9.0	4.0	-	-	3903_11:60704359-60704359 A>G_LKDPEELRNYMEGIRGSS	0.0
19:38934234-38934234 G>A	0.0	2359	MELANOMA	-	-	-	-	RYR1	NM_001042723,p.G103S|uc002oit.3,p.G103S|NM_000540,p.G103S|ENST00000355481,p.G103S|ENST00000360985,p.G103S|ENST00000359596,p.G103S|uc002oiu.3,p.G103S	retained_intron, protein_coding, nonsense_mediated_decay	uc002oiu.3	nonsynonymous SNV	exon4	c.G307A	p.G103S	SSQGGGHRTLLYGHAILLRHAHSRM	SSQGGGHRTLLYSHAILLRHAHSRM	3.0	2.0	-	-	2359_19:38934234-38934234 G>A_SSQGGGHRTLLYSHAILLRHAHSRM	0.0
6:138202176-138202176 C>T	1.0	4000	MELANOMA	-	-	-	1	TNFAIP3	uc031spw.1,p.S698L|uc031spv.1,p.S698L|NM_006290,p.S698L|NM_001270507,p.S698L|uc003qhr.4,p.S698L|ENST00000237289,p.S698L|NM_001270508,p.S698L|uc003qhs.4,p.S698L	protein_coding, processed_transcript	uc031spw.1	nonsynonymous SNV	exon9	c.C2093T	p.S698L	FHEAKRTEEQLRSSQRRDVPRTTQS	FHEAKRTEEQLRLSQRRDVPRTTQS	10.0	6.0	-	-	4000_6:138202176-138202176 C>T_FHEAKRTEEQLRLSQRRDVPRTTQS	0.0
7:73461078-73461078 C>G	0.0	3775	CERVICAL	-	-	-	2	ELN	uc003tzn.3,p.I208M|NM_001278915,p.I208M|NM_001278914,p.I203M|ENST00000429192,p.I213M|ENST00000357036,p.I213M|NM_001278939,p.I208M|NM_001278912,p.I208M|uc003tzv.3,p.I198M|uc003tzx.3,p.I198M|ENST00000252034,p.I208M|NM_001278917,p.I198M|ENST00000438906,p.I186M|NM_001278918,p.I164M|ENST00000380576,p.I208M|uc003tzu.3,p.I213M|ENST00000458204,p.I198M|ENST00000358929,p.I208M|uc003tzt.3,p.I213M|ENST00000414324,p.I203M|ENST00000380562,p.I208M|ENST00000320399,p.I208M|NM_000501,p.I208M|ENST00000428787,p.I126M|NM_001081752,p.I198M|uc003tzy.3,p.I203M|uc003tzw.3,p.I208M|uc003tzs.3,p.I208M|NM_001081753,p.I213M|uc011kff.2,p.I208M|ENST00000417091,p.I174M|NM_001081754,p.I213M|ENST00000445912,p.I208M|ENST00000380575,p.I198M|NM_001081755,p.I208M|uc003tzp.3,p.I164M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kff.2	nonsynonymous SNV	exon12	c.C624G	p.I208M	GGPQPGVPLGYPIKAPKLPGGYGLP	GGPQPGVPLGYPMKAPKLPGGYGLP	10.0	9.0	-	-	3775_7:73461078-73461078 C>G_GGPQPGVPLGYPMKAPKLPGGYGLP	0.0
9:14801809-14801809 G>A	0.0	4149	OVARIAN	-	-	-	-	FREM1	ENST00000380875,p.P1179S|uc003zlm.3,p.P1179S|ENST00000380880,p.P1179S|NM_144966,p.P1179S|ENST00000380881,p.P1180S|ENST00000422223,p.P1179S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zlm.3	nonsynonymous SNV	exon21	c.C3535T	p.P1179S	DSSIISAVDLDIPQDALLFSITQKP	DSSIISAVDLDISQDALLFSITQKP	3.0	8.0	-	-	4149_9:14801809-14801809 G>A_DSSIISAVDLDISQDALLFSITQKP	0.0
1:158064546-158064546 C>T	1.0	3919	MELANOMA	-	-	-	-	KIRREL	ENST00000368173,p.P653L|NM_001286349,p.P537L|ENST00000360089,p.P473L|ENST00000359209,p.P637L|uc009wsq.3,p.P473L|ENST00000392272,p.P534L|ENST00000368172,p.P451L|uc010pib.2,p.P537L|uc001frn.4,p.P637L|ENST00000416935,p.P537L|uc001fro.4,p.P451L|NM_018240,p.P637L	protein_coding	uc010pib.2	nonsynonymous SNV	exon13	c.C1610T	p.P537L	YRAPGPARFDGRPSSRLSHSSGYAQ	YRAPGPARFDGRLSSRLSHSSGYAQ	10.0	7.0	-	-	3919_1:158064546-158064546 C>T_YRAPGPARFDGRLSSRLSHSSGYAQ	0.0
8:143784578-143784578 A>C	0.0	4298	COLORECTAL	-	-	-	-	LY6K	uc011ljx.2,p.Q85H|ENST00000519387,p.Q85H|NM_001160355,p.Q85H	protein_coding, processed_transcript	uc011ljx.2	nonsynonymous SNV	exon3	c.A255C	p.Q85H	TVLRWLCSDGETQARGEAVSPGRAH	TVLRWLCSDGETHARGEAVSPGRAH	3.0	3.0	-	-	4298_8:143784578-143784578 A>C_TVLRWLCSDGETHARGEAVSPGRAH	0.0
6:99729152-99729152 T>G	1.0	4078	GASTRIC	-	-	-	-	FAXC	NM_032511,p.E373A|uc003ppi.4,p.E93A|ENST00000538471,p.E93A|uc003ppj.4,p.E373A|ENST00000389677,p.E373A	protein_coding, processed_transcript	uc003ppj.4	nonsynonymous SNV	exon6	c.A1118C	p.E373A	FSFYSRTETFEDEGAENSFSRTPDT	FSFYSRTETFEDAGAENSFSRTPDT	5.0	6.0	-	-	4078_6:99729152-99729152 T>G_FSFYSRTETFEDAGAENSFSRTPDT	0.0
2:38301661-38301661 C>T	0.0	4278	COLORECTAL	-	-	-	-	CYP1B1	uc002rqo.2,p.D291N|ENST00000260630,p.D291N|NM_000104,p.D291N|ENST00000407341,p.D291N	protein_coding, processed_transcript	uc002rqo.2	nonsynonymous SNV	exon2	c.G871A	p.D291N	HCESLRPGAAPRDMMDAFILSAEKK	HCESLRPGAAPRNMMDAFILSAEKK	9.0	10.0	-	-	4278_2:38301661-38301661 C>T_HCESLRPGAAPRNMMDAFILSAEKK	0.0
19:55494669-55494669 G>A	0.0	4252	COLORECTAL	-	-	ID=COSM295159;OCCURENCE=1(large_intestine)	-	NLRP2	ENST00000391721,p.V511I|NM_001174083,p.V512I|uc010esn.3,p.V511I|NM_017852,p.V535I|NM_001174081,p.V535I|ENST00000537859,p.V513I|ENST00000543010,p.V535I|ENST00000427260,p.V512I|uc010eso.3,p.V532I|uc002qij.3,p.V535I|ENST00000538819,p.V511I|uc021vbq.1,p.V535I|ENST00000339757,p.V513I|NM_001174082,p.V513I|ENST00000263437,p.V532I|uc010yfp.2,p.V512I|uc010esp.3,p.V513I|ENST00000448584,p.V535I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vbq.1	nonsynonymous SNV	exon6	c.G1603A	p.V535I	EDRDGHTWDIGDVQKLLSGVERLRN	EDRDGHTWDIGDIQKLLSGVERLRN	5.0	9.0	-	-	4252_19:55494669-55494669 G>A_EDRDGHTWDIGDIQKLLSGVERLRN	0.0
1:196706673-196706673 G>C	0.0	4246	COLORECTAL	-	-	-	-	CFH	NM_000186,p.E889Q|ENST00000367429,p.E889Q|uc001gtj.4,p.E889Q	retained_intron, protein_coding, ambiguous_orf	uc001gtj.4	nonsynonymous SNV	exon17	c.G2665C	p.E889Q	EHGTINSSRSSQESYAHGTKLSYTC	EHGTINSSRSSQQSYAHGTKLSYTC	6.0	8.0	-	-	4246_1:196706673-196706673 G>C_EHGTINSSRSSQQSYAHGTKLSYTC	0.0
5:151179537-151179537 C>T	1.0	3713	MELANOMA	-	-	-	-	G3BP1	uc003lun.3,p.P311S|ENST00000356245,p.P311S|uc010jhz.3,p.P129S|ENST00000543466,p.P129S|ENST00000394123,p.P311S|uc003lum.3,p.P311S|NM_005754,p.P311S|uc011dcu.2,p.P129S|NM_198395,p.P311S	retained_intron, protein_coding, nonsense_mediated_decay	uc011dcu.2	nonsynonymous SNV	exon9	c.C385T	p.P129S	RDQRVREQRINIPPQRGPRPIREAG	RDQRVREQRINISPQRGPRPIREAG	9.0	7.0	-	-	3713_5:151179537-151179537 C>T_RDQRVREQRINISPQRGPRPIREAG	0.0
10:99655131-99655131 G>A	1.0	4000	MELANOMA	-	-	-	-	CRTAC1	ENST00000298819,p.R453W|uc001kot.2,p.R243W|ENST00000370591,p.R453W|ENST00000413387,p.R349W|uc001kou.2,p.R453W|ENST00000370597,p.R453W|ENST00000309155,p.R445W|NM_001206528,p.R453W|NM_018058,p.R453W|uc001kov.3,p.R453W	protein_coding, processed_transcript	uc001kov.3	nonsynonymous SNV	exon11	c.C1357T	p.R453W	FNNNWLRVVPRTRFGAFARGAKVVL	FNNNWLRVVPRTWFGAFARGAKVVL	8.0	1.0	-	-	4000_10:99655131-99655131 G>A_FNNNWLRVVPRTWFGAFARGAKVVL	0.0
1:241798578-241798578 T>G	1.0	3879	MELANOMA	-	-	-	-	CHML	uc001hzd.3,p.E164A|NM_001821,p.E164A|ENST00000366553,p.E164A	protein_coding	uc001hzd.3	nonsynonymous SNV	exon1	c.A491C	p.E164A	EMPAKHTQKSDTEISLEVTDVEESV	EMPAKHTQKSDTAISLEVTDVEESV	10.0	8.0	-	-	3879_1:241798578-241798578 T>G_EMPAKHTQKSDTAISLEVTDVEESV	0.0
13:23912602-23912602 A>C	0.0	4275	COLORECTAL	-	-	-	-	SACS	NM_001278055,p.S1658A|uc001uon.3,p.S1805A|ENST00000402364,p.S1055A|NM_014363,p.S1805A|uc001uoo.3,p.S1658A|ENST00000382298,p.S1805A|ENST00000382292,p.S1805A	protein_coding, processed_transcript	uc001uoo.3	nonsynonymous SNV	exon8	c.T4972G	p.S1658A	FEMAKSGQSKKPSDELSQKTVECTT	FEMAKSGQSKKPADELSQKTVECTT	5.0	6.0	-	-	4275_13:23912602-23912602 A>C_FEMAKSGQSKKPADELSQKTVECTT	0.0
5:140812344-140812344 C>T	1.0	4213	COLORECTAL	-	-	-	-	PCDHGA12	NM_003735,p.A673V|uc011dba.2,p.A673V|ENST00000252085,p.A673V|uc003lkt.2,p.A673V|NM_032094,p.A673V	protein_coding	uc011dba.2	nonsynonymous SNV	exon1	c.C2018T	p.A673V	TVAVADSIPQVLADLGSLESPANSE	TVAVADSIPQVLVDLGSLESPANSE	6.0	8.0	-	-	4213_5:140812344-140812344 C>T_TVAVADSIPQVLVDLGSLESPANSE	0.0
11:128709978-128709978 A>C	0.0	4238	COLORECTAL	-	-	-	-	KCNJ1	NM_153767,p.L54R|NM_000220,p.L73R|ENST00000440599,p.L54R|uc001qep.2,p.L54R|NM_153764,p.L54R|uc021qsb.1,p.L54R|uc001qeq.2,p.L71R|ENST00000392666,p.L54R|uc001qes.2,p.L54R|uc001qer.2,p.L54R|ENST00000392665,p.L54R|ENST00000392664,p.L73R|ENST00000324003,p.L54R|NM_153765,p.L71R|uc001qeo.2,p.L73R|ENST00000324036,p.L54R|NM_153766,p.L54R	retained_intron, protein_coding	uc021qsb.1	nonsynonymous SNV	exon1	c.T161G	p.L54R	RFIFFVDIWTTVLDLKWRYKMTIFI	RFIFFVDIWTTVRDLKWRYKMTIFI	1.0	2.0	-	-	4238_11:128709978-128709978 A>C_RFIFFVDIWTTVRDLKWRYKMTIFI	0.0
15:52646177-52646177 G>A	1.0	4000	MELANOMA	-	-	-	1	MYO5A	ENST00000553916,p.S1153L|NM_000259,p.S1153L|ENST00000399233,p.S1153L|ENST00000356338,p.S1153L|uc002abx.3,p.S1153L|ENST00000358212,p.S1153L|NM_001142495,p.S1153L|uc002aby.2,p.S1153L|ENST00000399231,p.S1153L	retained_intron, protein_coding, nonsense_mediated_decay	uc002aby.2	nonsynonymous SNV	exon26	c.C3458T	p.S1153L	EEPSEKKVPLDMSLFLKLQKRVTEL	EEPSEKKVPLDMLLFLKLQKRVTEL	10.0	5.0	-	-	4000_15:52646177-52646177 G>A_EEPSEKKVPLDMLLFLKLQKRVTEL	0.0
4:25415962-25415962 C>T	1.0	3879	MELANOMA	-	-	-	-	ANAPC4	uc003gro.3,p.S547L|ENST00000510092,p.S548L|ENST00000315368,p.S547L|uc003grp.3,p.S433L|NM_013367,p.S547L|NM_001286756,p.S548L	retained_intron, protein_coding, nonsense_mediated_decay	uc003grp.3	nonsynonymous SNV	exon20	c.C1298T	p.S433L	QCLQKPADVIGKSMNQAICIPLYRD	QCLQKPADVIGKLMNQAICIPLYRD	9.0	6.0	-	-	3879_4:25415962-25415962 C>T_QCLQKPADVIGKLMNQAICIPLYRD	0.0
2:234854632-234854632 C>T	0.0	2591	MELANOMA	-	-	-	-	TRPM8	uc002vvh.3,p.R278W|ENST00000444298,p.R278W|NM_024080,p.R278W|ENST00000324695,p.R278W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002vvh.3	nonsynonymous SNV	exon7	c.C832T	p.R278W	GCHGHPTVEAKLRNQLEKYISERTI	GCHGHPTVEAKLWNQLEKYISERTI	5.0	7.0	-	-	2591_2:234854632-234854632 C>T_GCHGHPTVEAKLWNQLEKYISERTI	0.0
19:58153539-58153539 A>G	1.0	4326	BREAST	-	-	-	-	ZNF211	uc002qpr.2,p.E626G|NM_198855,p.E562G|uc010yhb.1,p.E566G|uc010yhe.2,p.E553G|NM_006385,p.E575G|ENST00000541801,p.E553G|NM_001265598,p.E614G|uc010yhd.2,p.E501G|uc031rng.1,p.E627G|ENST00000544273,p.E574G|ENST00000240731,p.E575G|ENST00000420680,p.E566G|ENST00000254182,p.E553G|NM_001265597,p.E627G|uc010yhc.1,p.E574G|NM_001265600,p.E501G|uc002qpq.2,p.E562G|ENST00000299871,p.E627G|ENST00000391703,p.E501G|uc002qpp.2,p.E575G|uc031rnh.1,p.E614G|uc002qpt.2,p.E574G|NM_001265599,p.E553G|ENST00000347302,p.E562G	retained_intron, protein_coding, nonsense_mediated_decay	uc031rnh.1	nonsynonymous SNV	exon4	c.A1841G	p.E614G	SVLIQHQRVHIGEKP	SVLIQHQRVHIGGKP	7.0	1.0	-	-	4326_19:58153539-58153539 A>G_SVLIQHQRVHIGGKP	0.0
6:10804057-10804057 C>T	0.0	4259	COLORECTAL	-	-	-	-	MAK	ENST00000536370,p.G187R|NM_001242385,p.G187R|uc021ylk.1,p.G187R|NM_001242957,p.G187R|ENST00000354489,p.G187R|ENST00000313243,p.G187R|NM_005906,p.G187R|uc003mzm.3,p.G187R|ENST00000474039,p.G187R|uc021yll.1,p.G187R|ENST00000538030,p.G187R	protein_coding, processed_transcript	uc021yll.1	nonsynonymous SNV	exon7	c.G559A	p.G187R	SVYSSPIDVWAVGSIMAELYMLRPL	SVYSSPIDVWAVRSIMAELYMLRPL	2.0	6.0	-	-	4259_6:10804057-10804057 C>T_SVYSSPIDVWAVRSIMAELYMLRPL	0.0
15:25932921-25932921 A>T	0.0	4246	COLORECTAL	-	-	-	-	ATP10A	uc010ayu.3,p.L1074M|ENST00000356865,p.L1074M|NM_024490,p.L1074M|ENST00000555756,p.L103M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ayu.3	nonsynonymous SNV	exon16	c.T3220A	p.L1074M	FAVPKFRYLERLLILHGHWCYSRLA	FAVPKFRYLERLMILHGHWCYSRLA	3.0	3.0	-	-	4246_15:25932921-25932921 A>T_FAVPKFRYLERLMILHGHWCYSRLA	0.0
X:63488670-63488670 G>T	0.0	3775	CERVICAL	-	-	-	-	MTMR8	uc004dvs.3,p.A621D|NM_017677,p.A621D|ENST00000374852,p.A621D	protein_coding, processed_transcript	uc004dvs.3	nonsynonymous SNV	exon14	c.C1862A	p.A621D	HHNCCEIVGSLRAINISGDVGISEA	HHNCCEIVGSLRDINISGDVGISEA	3.0	4.0	-	-	3775_X:63488670-63488670 G>T_HHNCCEIVGSLRDINISGDVGISEA	0.0
1:62976259-62976259 C>G	0.0	3775	CERVICAL	-	-	-	-	DOCK7	uc001dan.4,p.E1416D|NM_001272000,p.E1416D|uc010oov.1,p.E186D|uc001dam.3,p.E627D|ENST00000251157,p.E1447D|uc001daq.4,p.E1447D|uc001dap.4,p.E1425D|NM_001271999,p.E1447D|ENST00000340370,p.E1425D|uc001dao.4,p.E1416D|NM_001272001,p.E1416D|NM_033407,p.E1425D	protein_coding, processed_transcript	uc010oov.1	nonsynonymous SNV	exon5	c.G558C	p.E186D	WRKDMTHWRQNTEKLDKSRAEIEHE	WRKDMTHWRQNTDKLDKSRAEIEHE	6.0	9.0	-	-	3775_1:62976259-62976259 C>G_WRKDMTHWRQNTDKLDKSRAEIEHE	0.0
3:52172297-52172297 C>T	1.0	2369	MELANOMA	-	-	-	-	POC1A	uc003dcu.3,p.G234E|ENST00000394970,p.G234E|NM_001161580,p.G234E|ENST00000474012,p.G196E|ENST00000296484,p.G234E|NM_015426,p.G234E|uc003dcw.3,p.G234E|uc003dcv.3,p.G196E|NM_001161581,p.G196E	protein_coding	uc003dcw.3	nonsynonymous SNV	exon7	c.G701A	p.G234E	LQHYQLHSAAVNGLSFHPSGNYLIT	LQHYQLHSAAVNELSFHPSGNYLIT	5.0	8.0	-	-	2369_3:52172297-52172297 C>T_LQHYQLHSAAVNELSFHPSGNYLIT	0.0
7:128482396-128482396 G>A	1.0	3713	MELANOMA	-	-	-	-	FLNC	uc003voa.4,p.G745R|uc003vnz.4,p.G745R|ENST00000325888,p.G745R|ENST00000346177,p.G745R|NM_001458,p.G745R|NM_001127487,p.G745R	retained_intron, protein_coding	uc003voa.4	nonsynonymous SNV	exon14	c.G2233A	p.G745R	TKPIKHTIIISWGGVNVPKSPFRVN	TKPIKHTIIISWRGVNVPKSPFRVN	1.0	10.0	-	-	3713_7:128482396-128482396 G>A_TKPIKHTIIISWRGVNVPKSPFRVN	0.0
6:28539984-28539984 A>C	1.0	4244	COLORECTAL	-	-	-	-	ZBED9	NM_052923,p.L1228V|uc003nlo.3,p.L1228V|ENST00000452236,p.L1228V	protein_coding, processed_transcript	uc003nlo.3	nonsynonymous SNV	exon4	c.T3682G	p.L1228V	NLNLTVTLQDKLLKLATDEGLKISF	NLNLTVTLQDKLVKLATDEGLKISF	4.0	3.0	-	-	4244_6:28539984-28539984 A>C_NLNLTVTLQDKLVKLATDEGLKISF	0.0
5:71638803-71638803 A>C	0.0	4335	COLORECTAL	-	-	-	-	PTCD2	uc011csg.2,p.K84N|uc011csh.2,p.K147N|NM_001284403,p.K147N|ENST00000536805,p.K84N|uc003kcc.4,p.K85N|ENST00000308077,p.K256N|NM_001284404,p.K84N|ENST00000510676,p.K85N|ENST00000503868,p.K147N|uc011csf.1,p.K66N|NM_024754,p.K256N|uc003kcb.3,p.K256N|NM_001284405,p.K66N|ENST00000380639,p.K256N	protein_coding, processed_transcript, nonsense_mediated_decay	uc011csh.2	nonsynonymous SNV	exon5	c.A441C	p.K147N	AVALALNQNEMAKAVSIFSQIMNPE	AVALALNQNEMANAVSIFSQIMNPE	5.0	3.0	-	-	4335_5:71638803-71638803 A>C_AVALALNQNEMANAVSIFSQIMNPE	0.0
17:34641474-34641474 A>T	0.0	4238	COLORECTAL	-	-	-	-	CCL4L1,CCL4L2	ENST00000339270,p.K34M	retained_intron, protein_coding	ENST00000339270	nonsynonymous SNV	exon2	c.A101T	p.K34M	LSAPNSKPKEASKSALTPVSPGSRS	LSAPNSKPKEASMSALTPVSPGSRS	3.0	3.0	-	-	4238_17:34641474-34641474 A>T_LSAPNSKPKEASMSALTPVSPGSRS	0.0
8:28704326-28704326 C>T	1.0	3466	MELANOMA	-	-	-	-	INTS9	NM_018250,p.E67K|ENST00000520184,p.E43K|ENST00000523303,p.E67K|ENST00000518510,p.E67K|NM_001172562,p.E43K|ENST00000521777,p.E43K|ENST00000521022,p.E67K|ENST00000523436,p.E67K|uc011lav.2,p.E43K|uc003xha.3,p.E67K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lav.2	nonsynonymous SNV	exon4	c.G127A	p.E43K	WSLKDGNAFLDKELKECSGHVFVDS	WSLKDGNAFLDKKLKECSGHVFVDS	5.0	9.0	-	-	3466_8:28704326-28704326 C>T_WSLKDGNAFLDKKLKECSGHVFVDS	0.0
3:178921553-178921553 T>A	0.0	4081	COLORECTAL	-	-	ID=COSM754,COSM132748;OCCURENCE=1(lung),5(central_nervous_system),1(stomach),44(breast),4(large_intestine),1(prostate),2(urinary_tract),5(endometrium),1(salivary_gland)	1	PIK3CA	NM_006218,p.N345K|ENST00000263967,p.N345K|uc003fjk.3,p.N345K	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon5	c.T1035A	p.N345K	ALRIKILCATYVNVNIRDIDKIYVR	ALRIKILCATYVKVNIRDIDKIYVR	3.0	8.0	-	-	4081_3:178921553-178921553 T>A_ALRIKILCATYVKVNIRDIDKIYVR	0.0
21:47349844-47349844 T>G	0.0	4246	COLORECTAL	-	-	-	-	PCBP3	NM_020528,p.L244R|ENST00000449640,p.L244R|uc002zhp.2,p.L244R|ENST00000400310,p.L244R|ENST00000400305,p.L195R|uc002zhq.2,p.L244R|ENST00000400314,p.L244R|uc010gqb.3,p.L244R	retained_intron, protein_coding, processed_transcript	uc010gqb.3	nonsynonymous SNV	exon12	c.T731G	p.L244R	QYAIPHPDQLTKLHQLAMQQTPFPP	QYAIPHPDQLTKRHQLAMQQTPFPP	3.0	2.0	-	-	4246_21:47349844-47349844 T>G_QYAIPHPDQLTKRHQLAMQQTPFPP	0.0
8:110255281-110255281 G>C	0.0	4284	COLORECTAL	-	-	-	-	NUDCD1	NM_001128211,p.T541S|ENST00000427660,p.T541S|uc010mcl.3,p.T483S|uc003ynb.4,p.T570S|uc003yna.3,p.T541S|NM_032869,p.T570S|ENST00000239690,p.T570S	protein_coding, nonsense_mediated_decay	uc010mcl.3	nonsynonymous SNV	exon11	c.C1448G	p.T483S	GFQATNERLFVLTTKNLFLIKVNTE	GFQATNERLFVLSTKNLFLIKVNTE	7.0	1.0	-	-	4284_8:110255281-110255281 G>C_GFQATNERLFVLSTKNLFLIKVNTE	0.0
10:124457257-124457257 G>A	0.0	3998	MELANOMA	-	-	ID=COSM228140;OCCURENCE=1(skin)	-	C10orf120	ENST00000329446,p.H334Y|uc001lgn.3,p.H334Y|NM_001010912,p.H334Y	protein_coding	uc001lgn.3	nonsynonymous SNV	exon3	c.C1000T	p.H334Y	IWKERMRKATPYHY	IWKERMRKATPYYY	1.0	10.0	-	-	3998_10:124457257-124457257 G>A_IWKERMRKATPYYY	0.0
1:185902913-185902913 T>G	0.0	4329	COLORECTAL	-	-	-	-	HMCN1	ENST00000271588,p.S595R|uc001grq.1,p.S595R|NM_031935,p.S595R|ENST00000367492,p.S595R	protein_coding, processed_transcript	uc001grq.1	nonsynonymous SNV	exon11	c.T1785G	p.S595R	FNDAGEYHCMVSSEGGSSAASVFLT	FNDAGEYHCMVSREGGSSAASVFLT	7.0	7.0	-	-	4329_1:185902913-185902913 T>G_FNDAGEYHCMVSREGGSSAASVFLT	0.0
X:73963985-73963985 C>A	0.0	4126	NSCLC	-	-	-	-	KIAA2022	uc004eby.3,p.G136V|NM_001008537,p.G136V|ENST00000373468,p.G136V|ENST00000055682,p.G136V	protein_coding	uc004eby.3	nonsynonymous SNV	exon3	c.G407T	p.G136V	AIMEPAGMSALNGDCLMQPSRTCLG	AIMEPAGMSALNVDCLMQPSRTCLG	1.0	10.0	-	-	4126_X:73963985-73963985 C>A_AIMEPAGMSALNVDCLMQPSRTCLG	0.0
6:46107972-46107972 G>A	1.0	4320	COLORECTAL	-	-	-	-	ENPP4	ENST00000321037,p.V218I|NM_014936,p.V218I|uc003oxy.3,p.V218I	protein_coding	uc003oxy.3	nonsynonymous SNV	exon2	c.G652A	p.V218I	VLKKIDDLIGDLVQRLKMLGLWENL	VLKKIDDLIGDLIQRLKMLGLWENL	6.0	10.0	-	-	4320_6:46107972-46107972 G>A_VLKKIDDLIGDLIQRLKMLGLWENL	0.0
5:74491836-74491836 C>T	0.0	3775	CERVICAL	-	-	-	-	ANKRD31	ENST00000506364,p.E213K|NM_001164443,p.E213K|uc003kdo.2,p.E213K|ENST00000274361,p.E213K	protein_coding, processed_transcript	uc003kdo.2	nonsynonymous SNV	exon7	c.G637A	p.E213K	VTMTMTSEETKDEESSLETFVSALE	VTMTMTSEETKDKESSLETFVSALE	2.0	9.0	-	-	3775_5:74491836-74491836 C>T_VTMTMTSEETKDKESSLETFVSALE	0.0
20:45170125-45170125 C>T	0.0	4346	COLORECTAL	-	-	-	-	OCSTAMP	NM_080721,p.E497K|uc010zxu.2,p.E497K|ENST00000279028,p.E497K	protein_coding	uc010zxu.2	nonsynonymous SNV	exon3	c.G1489A	p.E497K	RLDALRTESSEGEGKELWSCRDLSC	RLDALRTESSEGKGKELWSCRDLSC	1.0	6.0	-	-	4346_20:45170125-45170125 C>T_RLDALRTESSEGKGKELWSCRDLSC	0.0
2:141116488-141116488 G>T	0.0	4278	COLORECTAL	-	-	-	1	LRP1B	uc002tvj.1,p.P3720H|ENST00000389484,p.P3720H|NM_018557,p.P3720H	protein_coding, processed_transcript	uc002tvj.1	nonsynonymous SNV	exon73	c.C11159A	p.P3720H	DMCVKFLCPSTRPHRCRNNRICLQS	DMCVKFLCPSTRHHRCRNNRICLQS	3.0	1.0	-	-	4278_2:141116488-141116488 G>T_DMCVKFLCPSTRHHRCRNNRICLQS	0.0
8:66631592-66631624 CTGCTCGACTGTTCTCTCTGCAGTCCCTTCCAG>-	0.0	4252	COLORECTAL	-	-	-	-	PDE7A	uc003xvp.3,p.424_435del|NM_001242318,p.450_461del|uc003xvq.3,p.450_461del|NM_002603,p.424_435del	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xvq.3	nonframeshift deletion	exon13	c.1350_1382del	p.450_461del	QTMLGHVGLNKASWKGLQREQSSSE	QTMLGHVGLNKASEDTDAAFELNSQ	8.0	6.0	-	-	4252_8:66631592-66631624 CTGCTCGACTGTTCTCTCTGCAGTCCCTTCCAG>-_QTMLGHVGLNKASEDTDAAFELNSQ	0.0
2:33745672-33745672 C>T	0.0	4335	COLORECTAL	-	-	ID=COSM1020541;OCCURENCE=1(endometrium)	-	RASGRP3	ENST00000407811,p.R97C|ENST00000437184,p.R97C|uc002roy.3,p.R97C|NM_001139488,p.R97C|NM_170672,p.R97C|ENST00000403687,p.R97C|ENST00000402538,p.R97C|ENST00000423159,p.R97C|NM_015376,p.R97C|uc002rox.3,p.R97C|uc010ync.2,p.R97C|ENST00000444784,p.R97C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ync.2	nonsynonymous SNV	exon6	c.C289T	p.R97C	FPAEFNLDLGLIRMTEEFREVASQL	FPAEFNLDLGLICMTEEFREVASQL	8.0	8.0	-	-	4335_2:33745672-33745672 C>T_FPAEFNLDLGLICMTEEFREVASQL	0.0
1:48260410-48260410 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	TRABD2B	uc021ong.1,p.T279N|ENST00000371865,p.T279N|NM_001194986,p.T279N	protein_coding, processed_transcript	uc021ong.1	nonsynonymous SNV	exon4	c.C836A	p.T279N	HDTSQLPNFINTTLPPHEQVTAQEI	HDTSQLPNFINTNLPPHEQVTAQEI	3.0	5.0	-	-	4258_1:48260410-48260410 G>T_HDTSQLPNFINTNLPPHEQVTAQEI	0.0
16:2815370-2815371 CA>-	1.0	4037	NSCLC	-	-	-	-	SRRM2	uc002crl.1,p.A1614fs|uc002crj.1,p.A1518fs|uc010bsu.1,p.A1518fs|uc002crk.3,p.A1614fs|ENST00000301740,p.A1614fs|NM_016333,p.A1614fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bsu.1	frameshift deletion	exon10	c.4553_4554del	p.A1518fs	PEVKDKPRAAPRAQSGSDSSPEPKA	PEVKDKPRAAPRAEWF	10.0	10.0	-	-	4037_16:2815370-2815371 CA>-_PEVKDKPRAAPRAEWF	0.0
2:33412001-33412001 G>A	0.0	2591	MELANOMA	-	-	ID=COSM1690448,COSM1690447;OCCURENCE=1(skin)	-	LTBP1	uc021vft.1,p.G427E|NM_000627,p.G101E|uc002rov.3,p.G101E|ENST00000407925,p.G101E|ENST00000404816,p.G427E|ENST00000390003,p.G101E|uc010yna.2,p.G101E|NM_001166266,p.G101E|NM_001166264,p.G101E|ENST00000354476,p.G427E|uc010ymz.2,p.G101E|ENST00000432635,p.G20E|ENST00000418533,p.G101E|ENST00000404525,p.G101E|ENST00000402934,p.G101E|uc002rou.3,p.G101E|NM_001166265,p.G101E|NM_206943,p.G427E	protein_coding, processed_transcript	uc021vft.1	nonsynonymous SNV	exon6	c.G1280A	p.G427E	SRDKCQCPPNFTGKLCQIPVHGASV	SRDKCQCPPNFTEKLCQIPVHGASV	3.0	3.0	-	-	2591_2:33412001-33412001 G>A_SRDKCQCPPNFTEKLCQIPVHGASV	0.0
15:72186088-72186088 G>A	1.0	3466	MELANOMA	-	-	-	-	MYO9A	uc002atm.1,p.P416S|uc002atn.1,p.P1673S|ENST00000444904,p.P1673S|ENST00000356056,p.P1692S|uc002atl.5,p.P1692S|ENST00000424560,p.P1692S|NM_006901,p.P1692S|uc002atk.3,p.P416S|ENST00000564571,p.P1692S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002atn.1	nonsynonymous SNV	exon24	c.C5017T	p.P1673S	PLVSKEALNSKNPQLHKEDEPAWKP	PLVSKEALNSKNSQLHKEDEPAWKP	8.0	2.0	-	-	3466_15:72186088-72186088 G>A_PLVSKEALNSKNSQLHKEDEPAWKP	0.0
9:18887873-18887873 C>T	1.0	3466	MELANOMA	-	-	-	-	ADAMTSL1	ENST00000542621,p.H133Y|ENST00000380548,p.H1432Y|ENST00000380538,p.H34Y|ENST00000380545,p.H133Y|uc003znf.4,p.H133Y|NM_001040272,p.H1432Y|uc003zne.4,p.H1432Y|ENST00000388710,p.H133Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003znf.4	nonsynonymous SNV	exon3	c.C397T	p.H133Y	IKGHPVPNITWFHGGQPIVTATGLT	IKGHPVPNITWFYGGQPIVTATGLT	8.0	9.0	-	-	3466_9:18887873-18887873 C>T_IKGHPVPNITWFYGGQPIVTATGLT	0.0
8:144999359-144999359 T>C	1.0	4335	COLORECTAL	-	-	-	-	PLEC	ENST00000354589,p.S1580G|NM_000445,p.S1607G|NM_201378,p.S1566G|uc003zah.2,p.S1566G|ENST00000527096,p.S1603G|uc003zae.1,p.S1548G|uc003zad.2,p.S1580G|NM_201383,p.S1584G|uc003zaj.2,p.S1607G|uc003zab.1,p.S1580G|uc003zaf.1,p.S1717G|ENST00000436759,p.S1607G|ENST00000356346,p.S1566G|uc003zag.1,p.S1558G|uc003zac.1,p.S1584G|NM_201382,p.S1580G|ENST00000357649,p.S1584G|ENST00000345136,p.S1580G|NM_201379,p.S1558G|ENST00000398774,p.S1548G|ENST00000322810,p.S1717G|NM_201384,p.S1580G|ENST00000354958,p.S1558G|NM_201380,p.S1717G|NM_201381,p.S1548G	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon32	c.A4819G	p.S1607G	ETAQRSAEAELQSKRASFAEKTAQL	ETAQRSAEAELQGKRASFAEKTAQL	10.0	2.0	-	-	4335_8:144999359-144999359 T>C_ETAQRSAEAELQGKRASFAEKTAQL	0.0
2:97877433-97877433 C>T	1.0	4244	COLORECTAL	-	-	-	-	ANKRD36	uc010yva.2,p.P1142S|NM_001164315,p.P1142S|ENST00000420699,p.P1142S|ENST00000461153,p.P1142S	retained_intron, protein_coding	uc010yva.2	nonsynonymous SNV	exon58	c.C3424T	p.P1142S	ALKAICDKEDSVPNMATEKKDEQIS	ALKAICDKEDSVSNMATEKKDEQIS	8.0	8.0	-	-	4244_2:97877433-97877433 C>T_ALKAICDKEDSVSNMATEKKDEQIS	0.0
4:113571737-113571737 G>C	1.0	4160	COLORECTAL	-	-	-	-	LARP7	uc003ibb.4,p.R472P|uc003iay.4,p.R472P|ENST00000513553,p.R140P|uc003iba.4,p.R393P|ENST00000324052,p.R472P|NM_015454,p.R472P|uc003iaz.4,p.R479P|NM_001267039,p.R479P|ENST00000509061,p.R479P|NM_016648,p.R472P|ENST00000344442,p.R472P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ibb.4	nonsynonymous SNV	exon10	c.G1415C	p.R472P	ISTEPLPGRKQVRDTLAAISEVLYV	ISTEPLPGRKQVPDTLAAISEVLYV	10.0	9.0	-	-	4160_4:113571737-113571737 G>C_ISTEPLPGRKQVPDTLAAISEVLYV	0.0
4:2254223-2254223 T>A	0.0	4320	COLORECTAL	-	-	-	-	MXD4	ENST00000337190,p.E74V|uc003geu.1,p.E74V|NM_006454,p.E74V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003geu.1	nonsynonymous SNV	exon4	c.A221T	p.E74V	EKHRRAKLRLYLEQLKQLVPLGPDS	EKHRRAKLRLYLVQLKQLVPLGPDS	6.0	6.0	-	-	4320_4:2254223-2254223 T>A_EKHRRAKLRLYLVQLKQLVPLGPDS	0.0
4:186320777-186320777 T>A	1.0	4071	COLORECTAL	-	-	-	-	ANKRD37	NM_181726,p.F109Y|uc003ixm.3,p.F109Y|ENST00000335174,p.F109Y|uc011cks.2,p.F109Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cks.2	nonsynonymous SNV	exon4	c.T326A	p.F109Y	GQTAEDLAWSCGFPDCAKFLTTIKC	GQTAEDLAWSCGYPDCAKFLTTIKC	5.0	10.0	-	-	4071_4:186320777-186320777 T>A_GQTAEDLAWSCGYPDCAKFLTTIKC	0.0
4:162376199-162376199 C>T	1.0	3879	MELANOMA	-	-	ID=COSM1695178;OCCURENCE=1(skin)	-	FSTL5	ENST00000306100,p.D600N|uc010iqv.4,p.D590N|NM_001128427,p.D599N|NM_001128428,p.D590N|uc003iqi.4,p.D599N|NM_020116,p.D600N|ENST00000379164,p.D599N|ENST00000427802,p.D590N|uc003iqh.4,p.D600N|ENST00000536695,p.D599N	protein_coding, processed_transcript	uc010iqv.4	nonsynonymous SNV	exon14	c.G1768A	p.D590N	TQPVGKQFDRVDDFFIPTTTLIITH	TQPVGKQFDRVDNFFIPTTTLIITH	7.0	8.0	-	-	3879_4:162376199-162376199 C>T_TQPVGKQFDRVDNFFIPTTTLIITH	0.0
19:37368592-37368592 T>A	0.0	4235	COLORECTAL	-	-	-	-	ZNF345	uc002oex.3,p.V287E|uc021utq.1,p.V287E|ENST00000589046,p.V287E|NM_001242476,p.V287E|NM_001242474,p.V287E|ENST00000529555,p.V287E|uc021uto.1,p.V287E|uc021utp.1,p.V287E|ENST00000420450,p.V287E|NM_001242472,p.V287E|NM_001242475,p.V287E|NM_003419,p.V287E|uc021utn.1,p.V287E|uc002oey.4,p.V287E	protein_coding, processed_transcript	uc021utq.1	nonsynonymous SNV	exon1	c.T860A	p.V287E	RHQRIHTGEKPYVCKECGKAFNSGS	RHQRIHTGEKPYECKECGKAFNSGS	5.0	2.0	-	-	4235_19:37368592-37368592 T>A_RHQRIHTGEKPYECKECGKAFNSGS	0.0
13:95899299-95899299 G>A	1.0	3713	MELANOMA	-	-	-	-	ABCC4	uc010afl.1,p.S36F|ENST00000412704,p.S79F|NM_001301830,p.S79F|uc001vmf.2,p.S36F|uc010afk.3,p.S79F|NM_001105515,p.S79F|ENST00000536256,p.S79F|ENST00000431522,p.S79F|NM_001301829,p.S79F|ENST00000376887,p.S79F|NM_005845,p.S79F|uc001vmd.4,p.S79F|uc010tih.1,p.S79F|uc001vme.2,p.S79F|uc010afm.1,p.S92F	protein_coding, processed_transcript	uc010tih.1	nonsynonymous SNV	exon3	c.C236T	p.S79F	EVLRAENDAQKPSLTRAIIKCYWKS	EVLRAENDAQKPFLTRAIIKCYWKS	1.0	3.0	-	-	3713_13:95899299-95899299 G>A_EVLRAENDAQKPFLTRAIIKCYWKS	0.0
19:52819135-52819135 G>T	1.0	4316	COLORECTAL	-	-	-	-	ZNF480	uc010ydl.2,p.R83M|ENST00000468240,p.R83M|NM_144684,p.R83M|ENST00000598016,p.R83M|ENST00000595962,p.R83M	protein_coding, nonsense_mediated_decay	uc010ydl.2	nonsynonymous SNV	exon4	c.G248T	p.R83M	PDLNINSMLEQRREPWSGESEVKIA	PDLNINSMLEQRMEPWSGESEVKIA	10.0	5.0	-	-	4316_19:52819135-52819135 G>T_PDLNINSMLEQRMEPWSGESEVKIA	0.0
3:50211766-50211766 C>T	1.0	4180	BREAST	-	-	-	-	SEMA3F	ENST00000414301,p.R147C|ENST00000450338,p.R147C|uc003cyk.3,p.R147C|ENST00000420831,p.R111C|ENST00000434342,p.R147C|ENST00000413852,p.R79C	retained_intron, protein_coding	uc003cyk.3	nonsynonymous SNV	exon5	c.C439T	p.R147C	TGAYNPMCTYVNRGRRAQDYIFYLE	TGAYNPMCTYVNCGRRAQDYIFYLE	9.0	8.0	-	-	4180_3:50211766-50211766 C>T_TGAYNPMCTYVNCGRRAQDYIFYLE	0.0
6:111695910-111695910 C>G	1.0	4244	COLORECTAL	-	-	-	-	REV3L	NM_001286432,p.E1138D|ENST00000435970,p.E1138D|NM_001286431,p.E1138D|ENST00000368802,p.E1216D|uc003puy.4,p.E1216D|ENST00000368805,p.E1216D|ENST00000358835,p.E1216D|uc003pux.4,p.E1138D|uc003puz.4,p.E1138D|NM_002912,p.E1216D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003puz.4	nonsynonymous SNV	exon15	c.G3414C	p.E1138D	GKKKPRAKQKTNEKGTSRKHTTLKD	GKKKPRAKQKTNDKGTSRKHTTLKD	7.0	3.0	-	-	4244_6:111695910-111695910 C>G_GKKKPRAKQKTNDKGTSRKHTTLKD	0.0
19:22575266-22575266 C>A	0.0	4213	COLORECTAL	-	-	-	-	ZNF98	ENST00000357774,p.K257N|NM_001098626,p.K257N|uc002nqt.2,p.K257N	protein_coding, processed_transcript	uc002nqt.2	nonsynonymous SNV	exon4	c.G771T	p.K257N	KAFNRLSHLTTHKIIHTGKKPYKCE	KAFNRLSHLTTHNIIHTGKKPYKCE	3.0	8.0	-	-	4213_19:22575266-22575266 C>A_KAFNRLSHLTTHNIIHTGKKPYKCE	0.0
1:150445476-150445476 G>T	1.0	4129	NSCLC	-	-	-	-	RPRD2	uc009wlr.3,p.G1351V|NM_001297674,p.G1325V|uc001eup.4,p.G1325V|NM_015203,p.G1351V|ENST00000369068,p.G1351V|ENST00000401000,p.G1325V	protein_coding, processed_transcript	uc009wlr.3	nonsynonymous SNV	exon11	c.G4052T	p.G1351V	HFGVLPGPRDHGGPTQRDLNGPGLS	HFGVLPGPRDHGVPTQRDLNGPGLS	6.0	9.0	-	-	4129_1:150445476-150445476 G>T_HFGVLPGPRDHGVPTQRDLNGPGLS	0.0
12:124957637-124957637 G>A	1.0	3678	MELANOMA	-	-	-	1	NCOR2	ENST00000448008,p.P72L|ENST00000405201,p.P151L|NM_006312,p.P151L|uc001ugj.1,p.P151L|ENST00000420698,p.P151L|ENST00000429285,p.P151L|uc001ugk.1,p.P151L|NM_001206654,p.P151L|ENST00000397355,p.P151L|uc010tba.2,p.P151L|uc010tbb.2,p.P151L|uc021rgc.1,p.P151L|ENST00000404621,p.P151L|NM_001077261,p.P151L|ENST00000458234,p.P151L|ENST00000356219,p.P151L|uc010tbc.2,p.P151L	retained_intron, protein_coding	uc021rgc.1	nonsynonymous SNV	exon6	c.C452T	p.P151L	RSLTGKLEPVSPPSPPHTDPELELV	RSLTGKLEPVSPLSPPHTDPELELV	10.0	7.0	-	-	3678_12:124957637-124957637 G>A_RSLTGKLEPVSPLSPPHTDPELELV	0.0
5:140474589-140474589 G>A	1.0	4000	MELANOMA	-	-	-	-	PCDHB2	NM_018936,p.G72E|uc003lil.3,p.G72E|ENST00000194155,p.G72E	protein_coding	uc003lil.3	nonsynonymous SNV	exon1	c.G215A	p.G72E	ELAVRGARVVSKGKKMHLQFDRQTG	ELAVRGARVVSKEKKMHLQFDRQTG	4.0	10.0	-	-	4000_5:140474589-140474589 G>A_ELAVRGARVVSKEKKMHLQFDRQTG	0.0
9:109734420-109734420 G>A	0.0	3775	CERVICAL	-	-	-	-	ZNF462	uc011lvz.2,p.E145K|ENST00000457913,p.E2248K|ENST00000277225,p.E2188K|uc004bcz.3,p.E2188K|uc010mto.3,p.E2097K|uc004bda.3,p.E2096K|uc004bdb.1,p.E96K|ENST00000542028,p.E145K|NM_021224,p.E2188K|ENST00000374686,p.E1131K|ENST00000441147,p.E1094K	protein_coding, processed_transcript	uc011lvz.2	nonsynonymous SNV	exon4	c.G433A	p.E145K	LSGAAAGTEQKTEAVLHCEFCEFSS	LSGAAAGTEQKTKAVLHCEFCEFSS	5.0	8.0	-	-	3775_9:109734420-109734420 G>A_LSGAAAGTEQKTKAVLHCEFCEFSS	0.0
4:48545867-48545867 G>A	1.0	3713	MELANOMA	-	-	-	-	FRYL	ENST00000537810,p.S1850F|NM_015030,p.S1850F|ENST00000503238,p.S1850F|uc003gyg.1,p.S546F|uc003gyj.1,p.S145F|ENST00000358350,p.S1850F|uc003gyi.1,p.S738F|uc003gyh.1,p.S1850F	retained_intron, protein_coding, processed_transcript	uc003gyj.1	nonsynonymous SNV	exon3	c.C434T	p.S145F	QPLTATTLSDVLSRLVETVGDPGED	QPLTATTLSDVLFRLVETVGDPGED	7.0	3.0	-	-	3713_4:48545867-48545867 G>A_QPLTATTLSDVLFRLVETVGDPGED	0.0
4:30725908-30725908 A>T	0.0	4259	COLORECTAL	-	-	-	-	PCDH7	NM_032456,p.E955V|NM_001173523,p.E955V|NM_002589,p.E955V|ENST00000543491,p.E955V|uc011bxx.2,p.E955V|ENST00000361762,p.E955V|uc003gsk.1,p.E955V|uc021xnc.1,p.E955V|uc021xnd.1,p.E955V|NM_032457,p.E955V	protein_coding, processed_transcript	uc021xnd.1	nonsynonymous SNV	exon1	c.A2864T	p.E955V	SKQPLYSSIVTVEASKPNGQRYDSV	SKQPLYSSIVTVVASKPNGQRYDSV	5.0	8.0	-	-	4259_4:30725908-30725908 A>T_SKQPLYSSIVTVVASKPNGQRYDSV	0.0
1:153737460-153737460 C>G	1.0	4240	BREAST	-	-	-	-	INTS3	ENST00000456435,p.L465V|ENST00000435409,p.L671V|uc001fcv.3,p.L465V|uc001fct.3,p.L671V|uc010pec.2,p.L184V|uc010peb.2,p.L465V|ENST00000318967,p.L671V|uc009wom.3,p.L671V|uc001fcu.3,p.L363V|NM_023015,p.L671V|ENST00000512605,p.L465V|uc001fcw.3,p.L184V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010pec.2	nonsynonymous SNV	exon8	c.C550G	p.L184V	LCQMQEDNSSFSLLLDLLSELYQKQ	LCQMQEDNSSFSVLLDLLSELYQKQ	9.0	8.0	-	-	4240_1:153737460-153737460 C>G_LCQMQEDNSSFSVLLDLLSELYQKQ	0.0
13:97995285-97995285 G>A	1.0	3784	MELANOMA	-	-	-	-	MBNL2	uc001vna.4,p.G119S|ENST00000343600,p.G119S|NM_207304,p.G119S|ENST00000397601,p.G119S|uc031qmz.1,p.G119S|ENST00000376673,p.G119S|ENST00000345429,p.G119S|uc001vmz.4,p.G119S|uc010aft.4,p.G119S|NM_144778,p.G119S|ENST00000469707,p.G119S	protein_coding, nonsense_mediated_decay	uc031qmz.1	nonsynonymous SNV	exon5	c.G355A	p.G119S	GTPLHPVPTFPVGPAIGTNTAISFA	GTPLHPVPTFPVSPAIGTNTAISFA	9.0	10.0	-	-	3784_13:97995285-97995285 G>A_GTPLHPVPTFPVSPAIGTNTAISFA	0.0
6:57015651-57015651 G>A	1.0	3678	MELANOMA	-	-	-	-	ZNF451	uc003pdl.4,p.G915S|ENST00000370706,p.G915S|uc003pdm.2,p.G915S|ENST00000491832,p.G915S|NM_001031623,p.G915S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003pdm.2	nonsynonymous SNV	exon11	c.G2743A	p.G915S	LPGHLNQGTFIWGFQGGNTNWKPPL	LPGHLNQGTFIWSFQGGNTNWKPPL	9.0	5.0	-	-	3678_6:57015651-57015651 G>A_LPGHLNQGTFIWSFQGGNTNWKPPL	0.0
1:201868580-201868580 G>T	0.0	4095	COLORECTAL	-	-	-	-	LMOD1	uc021phm.1,p.P521T|uc021phl.1,p.P521T|ENST00000367288,p.P521T|NM_012134,p.P521T|uc010ppu.2,p.P470T	protein_coding	uc021phm.1	nonsynonymous SNV	exon2	c.C1561A	p.P521T	PKPSPQPSPKPSPKNSPKKGGAPAA	PKPSPQPSPKPSTKNSPKKGGAPAA	7.0	6.0	-	-	4095_1:201868580-201868580 G>T_PKPSPQPSPKPSTKNSPKKGGAPAA	0.0
1:46489651-46489651 A>C	1.0	4252	COLORECTAL	-	-	-	-	MAST2	uc009vya.3,p.E515D	protein_coding, processed_transcript	uc009vya.3	nonsynonymous SNV	exon14	c.A1545C	p.E515D	TKRHLCMVMEYVEGTEAKVAWHGGQ	TKRHLCMVMEYVDGTEAKVAWHGGQ	8.0	8.0	-	-	4252_1:46489651-46489651 A>C_TKRHLCMVMEYVDGTEAKVAWHGGQ	0.0
8:16884892-16884892 C>T	0.0	4266	COLORECTAL	-	-	-	-	MICU3	ENST00000318063,p.T35I|NM_181723,p.T35I|uc003wxd.2,p.T35I	retained_intron, protein_coding, processed_transcript	uc003wxd.2	nonsynonymous SNV	exon1	c.C104T	p.T35I	PLLGPWGRPAVTTLGLPGRPFSSRE	PLLGPWGRPAVTILGLPGRPFSSRE	4.0	10.0	-	-	4266_8:16884892-16884892 C>T_PLLGPWGRPAVTILGLPGRPFSSRE	0.0
12:121687640-121687640 G>A	1.0	3466	MELANOMA	-	-	-	-	CAMKK2	ENST00000347034,p.R425C|uc001tzv.3,p.R425C|NM_001270486,p.R425C|ENST00000538733,p.R425C|uc001uab.3,p.R425C|ENST00000446440,p.R425C|uc001tzz.2,p.R212C|uc001uac.3,p.R425C|uc001tzy.3,p.R425C|uc001tzt.3,p.R425C|ENST00000412367,p.R425C|NM_153499,p.R425C|uc001uaa.2,p.R425C|NM_172214,p.R425C|ENST00000392473,p.R425C|NM_006549,p.R425C|uc001tzu.3,p.R425C|ENST00000545538,p.R212C|ENST00000404169,p.R425C|ENST00000392474,p.R425C|NM_172216,p.R425C|NM_153500,p.R425C|ENST00000324774,p.R425C|uc001tzw.3,p.R425C|NM_172215,p.R425C|uc001tzx.3,p.R425C|ENST00000337174,p.R425C|ENST00000402834,p.R425C|NM_172226,p.R425C|NM_001270485,p.R425C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001uac.3	nonsynonymous SNV	exon13	c.C1273T	p.R425C	PDIAEDLKDLITRMLDKNPESRIVV	PDIAEDLKDLITCMLDKNPESRIVV	6.0	9.0	-	-	3466_12:121687640-121687640 G>A_PDIAEDLKDLITCMLDKNPESRIVV	0.0
1:92946551-92946551 G>T	0.0	4335	COLORECTAL	-	-	-	-	GFI1	ENST00000427103,p.D131E|ENST00000370332,p.D131E|NM_005263,p.D131E|NM_001127215,p.D131E|ENST00000294702,p.D131E|uc001dov.4,p.D131E|uc001dow.4,p.D131E|uc001dou.4,p.D131E|NM_001127216,p.D131E	protein_coding, processed_transcript	uc001dow.4	nonsynonymous SNV	exon4	c.C393A	p.D131E	FKPYSWSGLAGSDLRHLVQSYRPCG	FKPYSWSGLAGSELRHLVQSYRPCG	5.0	3.0	-	-	4335_1:92946551-92946551 G>T_FKPYSWSGLAGSELRHLVQSYRPCG	0.0
16:3367700-3367700 G>T	1.0	4071	COLORECTAL	-	-	-	-	ZNF75A	NM_153028,p.G241V|ENST00000574298,p.G241V|uc002cut.4,p.G241V|NM_001302109,p.G482V	retained_intron, protein_coding, processed_transcript	uc002cut.4	nonsynonymous SNV	exon6	c.G722T	p.G241V	NTNLHTHQRTHTGEKPFTCHECGKK	NTNLHTHQRTHTVEKPFTCHECGKK	7.0	2.0	-	-	4071_16:3367700-3367700 G>T_NTNLHTHQRTHTVEKPFTCHECGKK	0.0
1:20991157-20991157 G>A	0.0	4238	COLORECTAL	-	-	-	-	KIF17	NM_020816,p.R1004C|uc001bdp.4,p.R281C|NM_001122819,p.R1003C|ENST00000247986,p.R1004C|uc001bds.4,p.R1003C|uc009vpx.3,p.R374C|ENST00000400463,p.R1003C|NM_001287212,p.R904C|uc001bdr.4,p.R1004C|ENST00000375044,p.R904C	protein_coding, processed_transcript	uc009vpx.3	nonsynonymous SNV	exon9	c.C1120T	p.R374C	TQAPEMPQPRPFRLESLDIPFTKAK	TQAPEMPQPRPFCLESLDIPFTKAK	4.0	10.0	-	-	4238_1:20991157-20991157 G>A_TQAPEMPQPRPFCLESLDIPFTKAK	0.0
3:155200651-155200651 C>A	1.0	4252	COLORECTAL	-	-	-	-	PLCH1	ENST00000460012,p.G1025V|ENST00000414191,p.G1025V|uc021xgf.1,p.G1025V|NM_001130960,p.G1063V|uc021xge.1,p.G1063V|NM_014996,p.G1025V|ENST00000340059,p.G1063V|ENST00000334686,p.G1025V	retained_intron, protein_coding	uc021xgf.1	nonsynonymous SNV	exon22	c.G3074T	p.G1025V	VTGEQLGMSSPRGGRTTSNATSNCQ	VTGEQLGMSSPRVGRTTSNATSNCQ	6.0	7.0	-	-	4252_3:155200651-155200651 C>A_VTGEQLGMSSPRVGRTTSNATSNCQ	0.0
1:150530443-150530443 T>A	0.0	4246	COLORECTAL	-	-	-	-	ADAMTSL4	uc010pcg.2,p.S695T|uc001eux.3,p.S734T|uc001euw.3,p.S734T|uc009wlw.3,p.S757T|NM_001288607,p.S695T|ENST00000369038,p.S734T|ENST00000271643,p.S734T|NM_019032,p.S734T|NM_025008,p.S734T|ENST00000369041,p.S734T|NM_001288608,p.S757T|ENST00000369039,p.S757T	retained_intron, protein_coding, processed_transcript	uc010pcg.2	nonsynonymous SNV	exon14	c.T2083A	p.S695T	PCPPYWEAGEWTSCSRSCGPGTQHR	PCPPYWEAGEWTTCSRSCGPGTQHR	5.0	9.0	-	-	4246_1:150530443-150530443 T>A_PCPPYWEAGEWTTCSRSCGPGTQHR	0.0
14:105409491-105409491 C>A	1.0	4126	NSCLC	-	-	-	-	AHNAK2	ENST00000333244,p.M4099I|uc001ypx.2,p.M3999I|NM_138420,p.M4099I|uc010axc.1,p.M4099I	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.G12297T	p.M4099I	VTAPDVKMSLSSMEVDVQAPRAKLD	VTAPDVKMSLSSIEVDVQAPRAKLD	9.0	3.0	-	-	4126_14:105409491-105409491 C>A_VTAPDVKMSLSSIEVDVQAPRAKLD	0.0
8:19276184-19276184 G>A	1.0	3903	MELANOMA	-	-	-	-	CSGALNACT1	NM_001130518,p.P404S|uc011kyn.2,p.P404S|ENST00000454498,p.P404S|ENST00000332246,p.P404S|ENST00000311540,p.P404S|ENST00000522854,p.P404S|uc011kyo.2,p.P404S|NM_018371,p.P404S|uc011kyp.2,p.P404S|ENST00000544602,p.P404S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011kyp.2	nonsynonymous SNV	exon7	c.C1210T	p.P404S	PGIIYGHHDAVPPLEQQLVIKKETG	PGIIYGHHDAVPSLEQQLVIKKETG	9.0	8.0	-	-	3903_8:19276184-19276184 G>A_PGIIYGHHDAVPSLEQQLVIKKETG	0.0
7:154585802-154585802 A>-	0.0	4284	COLORECTAL	-	-	-	-	DPP6	ENST00000377770,p.T384fs|uc011kvq.2,p.T277fs|uc003wlk.3,p.T384fs|NM_001936,p.T322fs|NM_001039350,p.T320fs|uc003wli.3,p.T320fs|ENST00000404039,p.T320fs|ENST00000332007,p.T322fs|uc003wlm.3,p.T322fs|ENST00000427557,p.T277fs|NM_130797,p.T384fs|NM_001290252,p.T277fs	retained_intron, protein_coding, processed_transcript	uc011kvq.2	frameshift deletion	exon9	c.829delA	p.T277fs	PPDDPRMREYYITMVKWATSTKVAV	PPDDPRMREYYIPW	4.0	3.0	-	-	4284_7:154585802-154585802 A>-_PPDDPRMREYYIPW	0.0
1:145457587-145457587 G>A	1.0	4234	NSCLC	-	-	-	-	POLR3GL	ENST00000369313,p.R92W	retained_intron, protein_coding	ENST00000369313	nonsynonymous SNV	exon4	c.C274T	p.R92W	PAVPKRDWRRLPRELKIRVRKLQKE	PAVPKRDWRRLPWELKIRVRKLQKE	9.0	1.0	-	-	4234_1:145457587-145457587 G>A_PAVPKRDWRRLPWELKIRVRKLQKE	0.0
2:220355633-220355633 G>T	0.0	4234	NSCLC	-	-	-	-	SPEG	ENST00000312358,p.A3114S|NM_005876,p.A3114S|uc010fwg.3,p.A3114S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010fwg.3	nonsynonymous SNV	exon38	c.G9340T	p.A3114S	VDFGSAQPYNPQALRPLGHRTGTLE	VDFGSAQPYNPQSLRPLGHRTGTLE	8.0	3.0	-	-	4234_2:220355633-220355633 G>T_VDFGSAQPYNPQSLRPLGHRTGTLE	0.0
3:43389259-43389259 A>T	0.0	4345	COLORECTAL	-	-	-	-	SNRK	ENST00000454177,p.E503V|ENST00000296088,p.E503V|uc011azr.2,p.E297V|NM_001100594,p.E503V|ENST00000437827,p.E297V|NM_017719,p.E503V|uc010hik.3,p.E503V|uc003cms.4,p.E503V|uc003cmt.4,p.E503V|ENST00000429705,p.E503V	retained_intron, protein_coding, processed_transcript	uc011azr.2	nonsynonymous SNV	exon5	c.A890T	p.E297V	EEGESDDEFDMDENLPPKLSRLKMN	EEGESDDEFDMDVNLPPKLSRLKMN	6.0	5.0	-	-	4345_3:43389259-43389259 A>T_EEGESDDEFDMDVNLPPKLSRLKMN	0.0
9:140685417-140685417 C>T	1.0	3713	MELANOMA	-	-	-	-	EHMT1	ENST00000462942,p.P453S|ENST00000460843,p.P834S|uc011mfc.2,p.P834S|NM_024757,p.P834S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mfc.2	nonsynonymous SNV	exon16	c.C2500T	p.P834S	VKYLIKAGALVDPKDAEGSTCLHLA	VKYLIKAGALVDSKDAEGSTCLHLA	8.0	5.0	-	-	3713_9:140685417-140685417 C>T_VKYLIKAGALVDSKDAEGSTCLHLA	0.0
X:21627575-21627575 T>G	0.0	4298	COLORECTAL	-	-	-	-	CNKSR2	uc004czw.3,p.S844R|uc004czy.3,p.S436R|ENST00000425654,p.S814R|ENST00000379510,p.S844R|NM_001168648,p.S844R|NM_001168647,p.S814R|uc004czx.2,p.S844R|NM_001168649,p.S795R|ENST00000543067,p.S795R|ENST00000279451,p.S844R|uc011mjn.2,p.S795R|uc011mjo.2,p.S814R|NM_014927,p.S844R	protein_coding, processed_transcript	uc011mjo.2	nonsynonymous SNV	exon19	c.T2442G	p.S814R	MQVLNGNGGKPRSFTLPRDSGFNHC	MQVLNGNGGKPRRFTLPRDSGFNHC	5.0	8.0	-	-	4298_X:21627575-21627575 T>G_MQVLNGNGGKPRRFTLPRDSGFNHC	0.0
7:157159199-157159199 A>C	1.0	4335	COLORECTAL	-	-	-	-	DNAJB6	ENST00000412557,p.K60T|ENST00000262177,p.K60T|uc010lqt.3,p.K60T|NM_058246,p.K60T|ENST00000417758,p.K60T|ENST00000453383,p.K60T|ENST00000443280,p.K60T|uc011kvz.2,p.K60T|uc003wnj.3,p.K60T|ENST00000441291,p.K60T|uc003wnl.3,p.K47T|NM_005494,p.K60T|ENST00000429029,p.K60T|uc003wnk.3,p.K60T|ENST00000441561,p.K60T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kvz.2	nonsynonymous SNV	exon4	c.A179C	p.K60T	QVAEAYEVLSDAKKRDIYDKYGKEG	QVAEAYEVLSDATKRDIYDKYGKEG	10.0	2.0	-	-	4335_7:157159199-157159199 A>C_QVAEAYEVLSDATKRDIYDKYGKEG	0.0
4:6087308-6087308 C>T	0.0	4301	MELANOMA	-	-	-	-	JAKMIP1	uc003giu.4,p.E225K|NM_144720,p.E225K|ENST00000409831,p.E225K|uc010ide.3,p.E225K|uc010idd.1,p.E225K|uc003giv.4,p.E225K|ENST00000282924,p.E225K|uc010idb.1,p.E225K|uc010idc.1,p.E60K|NM_001099433,p.E225K|ENST00000409021,p.E225K|uc011bwc.2,p.E60K|ENST00000473053,p.E225K|ENST00000410077,p.E60K|ENST00000409371,p.E60K	protein_coding, processed_transcript, nonsense_mediated_decay	uc011bwc.2	nonsynonymous SNV	exon3	c.G178A	p.E60K	KGKDRVILALEKELGVQAGQTQKLL	KGKDRVILALEKKLGVQAGQTQKLL	6.0	4.0	-	-	4301_4:6087308-6087308 C>T_KGKDRVILALEKKLGVQAGQTQKLL	0.0
11:124007301-124007301 A>C	0.0	4345	COLORECTAL	-	-	-	-	VWA5A	ENST00000456829,p.E515D|NM_001130142,p.E515D|uc001pzt.3,p.E515D|ENST00000392748,p.E515D|uc001pzu.3,p.E515D|NM_014622,p.E515D	retained_intron, protein_coding	uc001pzu.3	nonsynonymous SNV	exon14	c.A1545C	p.E515D	LTGRMPAAETTGEVCLKYTLQGKTF	LTGRMPAAETTGDVCLKYTLQGKTF	8.0	6.0	-	-	4345_11:124007301-124007301 A>C_LTGRMPAAETTGDVCLKYTLQGKTF	0.0
10:81050726-81050726 A>C	1.0	4335	COLORECTAL	-	-	-	-	ZMIZ1	uc001kaf.2,p.N184T|uc001kah.1,p.N60T|ENST00000334512,p.N184T|NM_020338,p.N184T|uc001kag.2,p.N60T	protein_coding, processed_transcript	uc001kah.1	nonsynonymous SNV	exon3	c.A179C	p.N60T	GVTNTSQSQVLGNPMANANNPMNPG	GVTNTSQSQVLGTPMANANNPMNPG	8.0	6.0	-	-	4335_10:81050726-81050726 A>C_GVTNTSQSQVLGTPMANANNPMNPG	0.0
2:232081438-232081438 C>T	0.0	4246	COLORECTAL	-	-	ID=COSM1195013,COSM1195012;OCCURENCE=2(lung)	-	ARMC9	ENST00000440107,p.L146F|uc002vrq.5,p.L146F|NM_025139,p.L146F|ENST00000349938,p.L146F|uc002vrp.5,p.L146F|NM_001291656,p.L146F|uc031rrs.1,p.L146F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031rrs.1	nonsynonymous SNV	exon5	c.C436T	p.L146F	TKGAALSQTTEFLPFYALPFVPNPM	TKGAALSQTTEFFPFYALPFVPNPM	6.0	10.0	CD8	-	4246_2:232081438-232081438 C>T_TKGAALSQTTEFFPFYALPFVPNPM	1.0
16:7760718-7760718 G>A	0.0	4110	BILE DUCT	-	-	-	-	RBFOX1	NM_145891,p.G410R|uc010uyc.1,p.G383R|uc002cys.2,p.G389R|ENST00000550418,p.G389R|ENST00000553186,p.G362R|ENST00000547338,p.G389R|NM_018723,p.G389R|uc002cyt.2,p.G362R|NM_001142334,p.G389R|ENST00000311745,p.G410R|uc002cyy.2,p.G410R|ENST00000340209,p.G394R|NM_001142333,p.G362R|uc010uyb.1,p.G389R	retained_intron, protein_coding, processed_transcript	uc010uyc.1	nonsynonymous SNV	exon12	c.G1147A	p.G383R	LVLSSLQASIYRGGYNRFAPY	LVLSSLQASIYRRGYNRFAPY	1.0	8.0	-	-	4110_16:7760718-7760718 G>A_LVLSSLQASIYRRGYNRFAPY	0.0
9:35401992-35401992 C>T	0.0	2369	MELANOMA	-	-	-	-	UNC13B	ENST00000378496,p.R1428C|uc003zwr.3,p.R1428C|ENST00000396787,p.R1440C	protein_coding, processed_transcript	uc003zwr.3	nonsynonymous SNV	exon37	c.C4282T	p.R1428C	GKGIRFTANEDIRPEKGSGVDDPVG	GKGIRFTANEDICPEKGSGVDDPVG	7.0	8.0	-	-	2369_9:35401992-35401992 C>T_GKGIRFTANEDICPEKGSGVDDPVG	0.0
9:108382246-108382246 G>A	1.0	3784	MELANOMA	-	-	-	-	FKTN	ENST00000357998,p.G359E|uc010mtm.3,p.G227E|NM_001198963,p.G359E|ENST00000448551,p.G359E|NM_006731,p.G359E|uc004bcr.3,p.G359E|ENST00000223528,p.G359E|uc004bcs.3,p.G359E|ENST00000602661,p.G359E|NM_001079802,p.G359E|uc011lvx.2,p.G359E	protein_coding, processed_transcript	uc011lvx.2	nonsynonymous SNV	exon10	c.G1076A	p.G359E	GKVEDSLELSFQGKDDVKLDVFFFY	GKVEDSLELSFQEKDDVKLDVFFFY	7.0	7.0	-	-	3784_9:108382246-108382246 G>A_GKVEDSLELSFQEKDDVKLDVFFFY	0.0
7:128485246-128485246 C>T	1.0	3466	MELANOMA	-	-	-	-	FLNC	NM_001458,p.H1243Y|ENST00000346177,p.H1243Y|uc003vnz.4,p.H1243Y|NM_001127487,p.H1243Y|uc003voa.4,p.H1243Y|ENST00000325888,p.H1243Y	retained_intron, protein_coding	uc003voa.4	nonsynonymous SNV	exon21	c.C3727T	p.H1243Y	GGHPVPKFPTRVHVQPAVDTSGVKV	GGHPVPKFPTRVYVQPAVDTSGVKV	3.0	9.0	-	-	3466_7:128485246-128485246 C>T_GGHPVPKFPTRVYVQPAVDTSGVKV	0.0
11:248971-248971 C>T	1.0	3713	MELANOMA	-	-	-	-	PSMD13	ENST00000528906,p.R192W|ENST00000431206,p.R232W|uc001loo.2,p.R232W|NM_175932,p.R232W|uc001lol.2,p.R230W|ENST00000352303,p.R230W|uc001lon.2,p.R165W|ENST00000532097,p.R230W|NM_002817,p.R230W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001loo.2	nonsynonymous SNV	exon7	c.C694T	p.R232W	MHPVLESLRNTDRQWLIDTLYAFNS	MHPVLESLRNTDWQWLIDTLYAFNS	9.0	10.0	-	-	3713_11:248971-248971 C>T_MHPVLESLRNTDWQWLIDTLYAFNS	0.0
10:70513718-70513718 C>A	1.0	4244	COLORECTAL	-	-	-	-	CCAR1	NM_018237,p.P410T|ENST00000265872,p.P410T|uc001jon.1,p.P356T|ENST00000541012,p.P410T|uc010qiz.1,p.P395T|uc001jom.1,p.P215T|ENST00000539539,p.P395T|uc010qja.1,p.P395T|uc009xpx.1,p.P384T|uc001joo.3,p.P410T|NM_001282960,p.P395T|NM_001282959,p.P395T|ENST00000543225,p.P384T|ENST00000535016,p.P395T|ENST00000543719,p.P395T|ENST00000536012,p.P215T|ENST00000540210,p.P410T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qja.1	nonsynonymous SNV	exon10	c.C1183A	p.P395T	QFTWVDAFPLSRPFQLGNYCNFYVM	QFTWVDAFPLSRTFQLGNYCNFYVM	10.0	8.0	-	-	4244_10:70513718-70513718 C>A_QFTWVDAFPLSRTFQLGNYCNFYVM	0.0
8:133111129-133111129 C>A	0.0	4298	COLORECTAL	-	-	-	-	HHLA1	ENST00000414222,p.D94Y|NM_001145095,p.D94Y|ENST00000434736,p.D130Y|uc011liy.1,p.D94Y	retained_intron, protein_coding	uc011liy.1	nonsynonymous SNV	exon4	c.G280T	p.D94Y	ELVNGMLSRALKDSKKFFSLLSVTS	ELVNGMLSRALKYSKKFFSLLSVTS	1.0	9.0	-	-	4298_8:133111129-133111129 C>A_ELVNGMLSRALKYSKKFFSLLSVTS	0.0
10:98820452-98820452 G>A	0.0	2591	MELANOMA	-	-	-	-	SLIT1	ENST00000371041,p.R296C|NM_003061,p.R296C|uc009xvh.1,p.R296C|ENST00000314867,p.R279C|ENST00000266058,p.R296C|uc001kmw.2,p.R296C|ENST00000371070,p.R296C	protein_coding, processed_transcript	uc009xvh.1	nonsynonymous SNV	exon9	c.C886T	p.R296C	AMCTCSNGIVDCRGKGLTAIPANLP	AMCTCSNGIVDCCGKGLTAIPANLP	2.0	4.0	-	-	2591_10:98820452-98820452 G>A_AMCTCSNGIVDCCGKGLTAIPANLP	0.0
11:129940523-129940523 G>T	0.0	4335	COLORECTAL	-	-	-	-	APLP2	NM_001243299,p.G6W|ENST00000278756,p.G6W|uc021qsg.1,p.G6W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qsg.1	nonsynonymous SNV	exon1	c.G16T	p.G6W	MLRAPGELPRQAARCSLC	MLRAPWELPRQAARCSLC	10.0	7.0	-	-	4335_11:129940523-129940523 G>T_MLRAPWELPRQAARCSLC	0.0
17:39767891-39767891 T>G	1.0	4245	COLORECTAL	-	-	-	-	KRT16	ENST00000301653,p.K205T|uc002hxg.4,p.K205T|NM_005557,p.K205T	retained_intron, protein_coding	uc002hxg.4	nonsynonymous SNV	exon2	c.A614C	p.K205T	DNARLAADDFRTKYEHELALRQTVE	DNARLAADDFRTTYEHELALRQTVE	5.0	3.0	-	-	4245_17:39767891-39767891 T>G_DNARLAADDFRTTYEHELALRQTVE	0.0
3:124413193-124413193 C>T	1.0	4000	MELANOMA	-	-	-	-	KALRN	NM_007064,p.L777F|ENST00000428018,p.L745F|ENST00000291478,p.L777F|uc003ehg.3,p.L2474F|uc003ehk.3,p.L777F|NM_001024660,p.L2474F|ENST00000360013,p.L2474F	retained_intron, protein_coding, processed_transcript	uc003ehk.3	nonsynonymous SNV	exon20	c.C2329T	p.L777F	NPNFIQEVAPEFLVPLVDVTCLLGD	NPNFIQEVAPEFFVPLVDVTCLLGD	8.0	4.0	-	-	4000_3:124413193-124413193 C>T_NPNFIQEVAPEFFVPLVDVTCLLGD	0.0
5:78322369-78322369 C>G	0.0	3775	CERVICAL	-	-	-	-	DMGDH	ENST00000540686,p.D310H|uc011cte.1,p.D540H|uc011ctf.1,p.D489H|uc011ctg.1,p.D310H|ENST00000523732,p.D529H|uc003kfs.3,p.D690H|ENST00000380311,p.D489H|NM_013391,p.D690H|ENST00000255189,p.D690H	protein_coding, processed_transcript, nonsense_mediated_decay	uc011ctg.1	nonsynonymous SNV	exon8	c.G928C	p.D310H	GELGWELYHRREDSVALYDAIMNAG	GELGWELYHRREHSVALYDAIMNAG	3.0	7.0	-	-	3775_5:78322369-78322369 C>G_GELGWELYHRREHSVALYDAIMNAG	0.0
2:169783670-169783670 G>A	0.0	4284	COLORECTAL	-	-	-	-	ABCB11	NM_003742,p.P1205L|uc010zda.1,p.P623L|uc002ueo.1,p.P1205L|ENST00000263817,p.P1205L|uc010zdb.1,p.P681L	retained_intron, protein_coding, nonsense_mediated_decay	uc010zdb.1	nonsynonymous SNV	exon13	c.C2042T	p.P681L	KQAQLHDFVMSLPEKYETNVGSQGS	KQAQLHDFVMSLLEKYETNVGSQGS	3.0	6.0	-	-	4284_2:169783670-169783670 G>A_KQAQLHDFVMSLLEKYETNVGSQGS	0.0
15:85619107-85619107 C>T	1.0	4213	COLORECTAL	-	-	-	-	PDE8A	ENST00000339708,p.S150L|ENST00000478717,p.S150L|ENST00000485596,p.S150L|ENST00000559742,p.S150L|NM_173454,p.S150L|ENST00000310298,p.S150L|NM_001243137,p.S78L|uc002bli.3,p.S150L|ENST00000557957,p.S78L|uc002blh.3,p.S150L|ENST00000394553,p.S150L|NM_002605,p.S150L|uc021stv.1,p.S78L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021stv.1	nonsynonymous SNV	exon4	c.C233T	p.S78L	LDAEALCRSIRSSKLSENTVIVGVV	LDAEALCRSIRSLKLSENTVIVGVV	9.0	6.0	-	-	4213_15:85619107-85619107 C>T_LDAEALCRSIRSLKLSENTVIVGVV	0.0
20:42788700-42788700 G>A	0.0	4246	COLORECTAL	-	-	-	-	JPH2	ENST00000372980,p.R243C|NM_020433,p.R243C|uc002xli.1,p.R243C	protein_coding	uc002xli.1	nonsynonymous SNV	exon2	c.C727T	p.R243C	RRAESRTSVGSQRSRVSFLKSDLSS	RRAESRTSVGSQCSRVSFLKSDLSS	3.0	3.0	-	-	4246_20:42788700-42788700 G>A_RRAESRTSVGSQCSRVSFLKSDLSS	0.0
1:46073339-46073339 A>C	1.0	4320	COLORECTAL	-	-	-	-	NASP	ENST00000402363,p.E254D|uc001cok.2,p.E135D|uc010olr.2,p.E188D|NM_001195193,p.E188D|uc021omz.1,p.E254D|uc010olq.2,p.E215D|ENST00000470768,p.E215D|uc001coi.2,p.E252D|NM_002482,p.E252D|ENST00000350030,p.E252D|ENST00000537798,p.E188D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021omz.1	nonsynonymous SNV	exon7	c.A762C	p.E254D	EEEKSVSGTDVQEECREKGGQEKQG	EEEKSVSGTDVQDECREKGGQEKQG	10.0	3.0	-	-	4320_1:46073339-46073339 A>C_EEEKSVSGTDVQDECREKGGQEKQG	0.0
8:100975135-100975137 TTC>-	0.0	4196	COLORECTAL	-	-	-	-	RGS22	ENST00000523287,p.1048_1048del|ENST00000360863,p.1229_1229del|NM_001286692,p.1217_1217del|uc003yjb.1,p.1229_1229del|uc003yjc.1,p.1217_1217del|uc003yja.1,p.1048_1048del|uc022azf.1,p.618_618del|NM_001286693,p.1048_1048del|ENST00000523437,p.1217_1217del|NM_015668,p.1229_1229del	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022azf.1	nonframeshift deletion	exon14	c.1852_1854del	p.618_618del	LEQERILLKIQEELEKKLFAGLQPL	LEQERILLKIQELEKKLFAGLQPLT	5.0	4.0	-	-	4196_8:100975135-100975137 TTC>-_LEQERILLKIQELEKKLFAGLQPLT	0.0
17:26712088-26712088 C>A	1.0	3919	MELANOMA	-	-	-	-	SARM1	uc002hbe.1,p.T19N|ENST00000457710,p.T441N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hbe.1	nonsynonymous SNV	exon2	c.C56A	p.T19N	RKRFFRELTELKTFANYSTCDRSNL	RKRFFRELTELKNFANYSTCDRSNL	10.0	3.0	-	-	3919_17:26712088-26712088 C>A_RKRFFRELTELKNFANYSTCDRSNL	0.0
1:210856714-210856714 G>A	0.0	4301	MELANOMA	-	-	ID=COSM1689791;OCCURENCE=1(skin)	-	KCNH1	uc001hib.2,p.S960F|uc001hic.2,p.S933F|ENST00000367007,p.S933F|NM_172362,p.S960F|NM_002238,p.S933F|ENST00000271751,p.S960F	protein_coding	uc001hic.2	nonsynonymous SNV	exon11	c.C2798T	p.S933F	EKQLSEILRILTSRRSSQSPQELFE	EKQLSEILRILTFRRSSQSPQELFE	2.0	5.0	-	-	4301_1:210856714-210856714 G>A_EKQLSEILRILTFRRSSQSPQELFE	0.0
18:50432624-50432624 G>A	0.0	4301	MELANOMA	-	-	-	2	DCC	ENST00000442544,p.G208E|ENST00000412726,p.G56E|uc010xdr.1,p.G56E|NM_005215,p.G208E|uc002lfe.2,p.G208E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xdr.1	nonsynonymous SNV	exon3	c.G167A	p.G56E	ALQISRLQPGDIGIYRCSARNPASS	ALQISRLQPGDIEIYRCSARNPASS	4.0	8.0	-	-	4301_18:50432624-50432624 G>A_ALQISRLQPGDIEIYRCSARNPASS	0.0
11:61549105-61549105 C>T	0.0	4081	COLORECTAL	-	-	-	-	MYRF	ENST00000389602,p.S333L|uc010rll.1,p.S333L|uc001nse.1,p.S907L|uc001nsc.1,p.S942L|ENST00000265460,p.S907L|NM_013279,p.S907L|ENST00000278836,p.S942L|NM_001127392,p.S942L	retained_intron, protein_coding	uc010rll.1	nonsynonymous SNV	exon10	c.C998T	p.S333L	PVTNIRAKSWGLSVNGIGHSKHHKS	PVTNIRAKSWGLLVNGIGHSKHHKS	3.0	7.0	-	-	4081_11:61549105-61549105 C>T_PVTNIRAKSWGLLVNGIGHSKHHKS	0.0
9:123169329-123169329 C>T	1.0	4246	COLORECTAL	-	-	-	-	CDK5RAP2	uc010mvi.3,p.V651M|ENST00000416449,p.V1036M|uc011lya.3,p.V907M|NM_018249,p.V1642M|ENST00000425647,p.V652M|uc011lxz.3,p.V907M|uc011lxw.3,p.V907M|ENST00000360822,p.V1610M|NM_001272039,p.V1412M|uc004bkf.4,p.V1642M|ENST00000349780,p.V1642M|uc004bke.3,p.V927M|ENST00000359309,p.V1601M|uc004bkh.2,p.V1412M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lya.3	nonsynonymous SNV	exon32	c.G2719A	p.V907M	AQEGALTLAVQAVSIPEVPLQPDKH	AQEGALTLAVQAMSIPEVPLQPDKH	10.0	9.0	-	-	4246_9:123169329-123169329 C>T_AQEGALTLAVQAMSIPEVPLQPDKH	0.0
3:32586554-32586554 G>A	1.0	4240	BREAST	-	-	-	-	DYNC1LI1	ENST00000413350,p.H77Y|ENST00000273130,p.H128Y|uc003cfb.4,p.H128Y|NM_016141,p.H128Y|ENST00000424991,p.H169Y	retained_intron, protein_coding	uc003cfb.4	nonsynonymous SNV	exon4	c.C382T	p.H128Y	RCNVWILDGDLYHKGLLKFSLDAVS	RCNVWILDGDLYYKGLLKFSLDAVS	8.0	10.0	-	-	4240_3:32586554-32586554 G>A_RCNVWILDGDLYYKGLLKFSLDAVS	0.0
2:179505979-179505979 T>G	0.0	4160	COLORECTAL	-	-	-	-	TTN	ENST00000359218,p.K4601T|ENST00000414766,p.K862T|NM_001267550,p.K13541T|uc021vsy.2,p.K10973T|NM_001256850,p.K11900T|ENST00000460472,p.K4476T|uc031rqd.1,p.K11900T|ENST00000591111,p.K11900T|uc021vtb.2,p.K4476T|uc031rqc.1,p.K13541T|NM_133437,p.K4668T|NM_133432,p.K4601T|NM_133378,p.K10973T|NM_003319,p.K4476T|uc021vta.2,p.K4601T|uc010fre.1,p.K851T|ENST00000589042,p.K13541T|ENST00000342992,p.K10973T|ENST00000342175,p.K4668T|uc021vsz.2,p.K4668T	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon170	c.A35699C	p.K11900T	EPKVEPKKLEKVKKPAVPEPPPPKP	EPKVEPKKLEKVTKPAVPEPPPPKP	1.0	5.0	-	-	4160_2:179505979-179505979 T>G_EPKVEPKKLEKVTKPAVPEPPPPKP	0.0
4:148575273-148575273 G>A	1.0	2556	MELANOMA	-	-	-	1	PRMT9	NM_138364,p.S592F|ENST00000322396,p.S592F|uc003ilc.3,p.S592F|uc003ilb.3,p.S236F|ENST00000541232,p.S479F|uc003ild.3,p.S479F	retained_intron, protein_coding, nonsense_mediated_decay	uc003ild.3	nonsynonymous SNV	exon8	c.C1436T	p.S479F	EPFYVLDVSEGFSVLPVIAGTLGQV	EPFYVLDVSEGFFVLPVIAGTLGQV	6.0	3.0	-	-	2556_4:148575273-148575273 G>A_EPFYVLDVSEGFFVLPVIAGTLGQV	0.0
7:73461078-73461078 C>G	0.0	3775	CERVICAL	-	-	-	2	ELN	uc003tzo.3,p.I208M|ENST00000380553,p.I105M|NM_001278913,p.I186M|uc003tzq.3,p.I105M|uc003tzz.3,p.I186M|ENST00000320492,p.I186M|ENST00000438880,p.I83M|ENST00000380584,p.I208M|NM_001278916,p.I208M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003tzz.3	nonsynonymous SNV	exon10	c.C558G	p.I186M	GGPQPGVPLGYPIKAPKLPGYGPGG	GGPQPGVPLGYPMKAPKLPGYGPGG	10.0	9.0	-	-	3775_7:73461078-73461078 C>G_GGPQPGVPLGYPMKAPKLPGYGPGG	0.0
16:58438421-58438421 C>T	1.0	3713	MELANOMA	-	-	ID=COSM3818177,COSM3818178;OCCURENCE=1(breast)	-	GINS3	uc002enh.4,p.R147C|uc010cdj.3,p.R186C|ENST00000426538,p.R186C|NM_022770,p.R147C|ENST00000318129,p.R147C|NM_001126129,p.R186C	retained_intron, protein_coding, processed_transcript	uc010cdj.3	nonsynonymous SNV	exon4	c.C556T	p.R186C	SQSLLQTFIGRFRRIMDSSQNAYNE	SQSLLQTFIGRFCRIMDSSQNAYNE	4.0	2.0	-	-	3713_16:58438421-58438421 C>T_SQSLLQTFIGRFCRIMDSSQNAYNE	0.0
7:140301539-140301539 G>A	0.0	4301	MELANOMA	0.0027	-	-	-	DENND2A	ENST00000275884,p.S220L|uc003vvw.3,p.S220L|ENST00000492720,p.S220L|ENST00000537639,p.S220L|uc010lnk.3,p.S220L|ENST00000496613,p.S220L|uc003vvx.3,p.S220L|NM_015689,p.S220L|uc010lnj.3,p.S220L|ENST00000461883,p.S220L	protein_coding, nonsense_mediated_decay	uc010lnk.3	nonsynonymous SNV	exon3	c.C659T	p.S220L	GSGSEVSQRVHPSDLEGREPTPELV	GSGSEVSQRVHPLDLEGREPTPELV	6.0	8.0	-	-	4301_7:140301539-140301539 G>A_GSGSEVSQRVHPLDLEGREPTPELV	0.0
X:96213055-96213055 C>T	1.0	2556	MELANOMA	-	-	-	-	DIAPH2	NM_007309,p.P615S|uc004efu.4,p.P615S|ENST00000373054,p.P611S|ENST00000355827,p.P615S|ENST00000373049,p.P615S|ENST00000373061,p.P615S|uc004eft.4,p.P615S|ENST00000324765,p.P615S|NM_006729,p.P615S	protein_coding	uc004efu.4	nonsynonymous SNV	exon16	c.C1843T	p.P615S	PPPPPPLGGVPPPPGISLNLPYGMK	PPPPPPLGGVPPSPGISLNLPYGMK	8.0	9.0	-	-	2556_X:96213055-96213055 C>T_PPPPPPLGGVPPSPGISLNLPYGMK	0.0
7:2041710-2041710 C>T	1.0	2369	MELANOMA	-	-	-	-	MAD1L1	uc010ksh.1,p.R469K|uc010ksj.3,p.R469K|ENST00000444373,p.R59K|ENST00000406869,p.R469K|uc003sle.1,p.R198K|uc003slh.1,p.R469K|uc003sli.1,p.R377K|uc010ksi.1,p.R422K|uc003slf.1,p.R469K|NM_001013836,p.R469K|ENST00000402746,p.R377K|ENST00000265854,p.R469K|NM_003550,p.R469K|uc003slg.1,p.R469K|NM_001013837,p.R469K|ENST00000438959,p.R136K|ENST00000399654,p.R469K	protein_coding, processed_transcript	uc010ksj.3	nonsynonymous SNV	exon14	c.G1406A	p.R469K	SQALEELGGQKQRADMLEMELKMLK	SQALEELGGQKQKADMLEMELKMLK	10.0	5.0	-	-	2369_7:2041710-2041710 C>T_SQALEELGGQKQKADMLEMELKMLK	0.0
10:44112052-44112052 A>C	1.0	4196	COLORECTAL	-	-	-	-	ZNF485	NM_145312,p.R187S|ENST00000374435,p.R187S|uc010qfd.2,p.R96S|uc010qfc.2,p.R187S|ENST00000374437,p.R96S|ENST00000361807,p.R187S	retained_intron, protein_coding	uc010qfd.2	nonsynonymous SNV	exon3	c.A288C	p.R96S	NHHKVHAGKQPYRCIECGKFLKKHS	NHHKVHAGKQPYSCIECGKFLKKHS	7.0	7.0	-	-	4196_10:44112052-44112052 A>C_NHHKVHAGKQPYSCIECGKFLKKHS	0.0
19:17692118-17692118 C>G	1.0	4284	COLORECTAL	-	-	-	-	COLGALT1	uc002nhc.1,p.N578K|ENST00000252599,p.N578K|NM_024656,p.N578K	retained_intron, protein_coding, processed_transcript	uc002nhc.1	nonsynonymous SNV	exon12	c.C1734G	p.N578K	GYVSDTETSVVWNNEHVKTDWDRAK	GYVSDTETSVVWKNEHVKTDWDRAK	9.0	6.0	-	-	4284_19:17692118-17692118 C>G_GYVSDTETSVVWKNEHVKTDWDRAK	0.0
7:100336109-100336109 T>A	0.0	4246	COLORECTAL	-	-	-	-	ZAN	ENST00000542585,p.F213L|ENST00000538115,p.F213L|uc003uwk.3,p.F213L|uc003uwj.3,p.F213L|ENST00000546292,p.F213L	protein_coding, polymorphic_pseudogene	uc003uwk.3	nonsynonymous SNV	exon7	c.T639A	p.F213L	SCNRVCMMQTCSFDIPNDLCDWTWI	SCNRVCMMQTCSLDIPNDLCDWTWI	1.0	2.0	-	-	4246_7:100336109-100336109 T>A_SCNRVCMMQTCSLDIPNDLCDWTWI	0.0
1:247024356-247024356 G>A	1.0	3713	MELANOMA	-	-	-	-	AHCTF1	uc001ibv.2,p.S1335L|NM_015446,p.S1335L|ENST00000326225,p.S1335L|ENST00000391829,p.S1326L|uc009xgs.1,p.S187L|ENST00000366508,p.S1361L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009xgs.1	nonsynonymous SNV	exon20	c.C560T	p.S187L	SDETTLEYQDAPSPEDLEETVFTAS	SDETTLEYQDAPLPEDLEETVFTAS	8.0	4.0	-	-	3713_1:247024356-247024356 G>A_SDETTLEYQDAPLPEDLEETVFTAS	0.0
22:30824484-30824484 A>C	1.0	4320	COLORECTAL	-	-	-	-	MTFP1	uc003ahw.2,p.K155T|ENST00000266263,p.K155T|NM_016498,p.K155T|ENST00000407550,p.K132T|ENST00000439838,p.K327T|uc003ahv.1,p.K317T	 protein_coding,retained_intron, nonsense_mediated_decay	uc003ahw.2	nonsynonymous SNV	exon4	c.A464C	p.K155T	RSVDFLLDSSLRKLYPTVGKPSSS	RSVDFLLDSSLRTLYPTVGKPSSS	6.0	4.0	-	-	4320_22:30824484-30824484 A>C_RSVDFLLDSSLRTLYPTVGKPSSS	0.0
1:235577773-235577773 C>T	1.0	3713	MELANOMA	-	-	-	-	TBCE	uc001hwz.1,p.R71C|ENST00000543662,p.R71C|NM_001287801,p.R71C|NM_001079515,p.R71C|NM_003193,p.R71C|uc001hxa.1,p.R71C|ENST00000406207,p.R71C|uc010pxr.1,p.R71C|ENST00000366601,p.R71C	protein_coding, processed_transcript	uc010pxr.1	nonsynonymous SNV	exon4	c.C211T	p.R71C	FKCRHPTGGSFIRPNKVNFGTDFLT	FKCRHPTGGSFICPNKVNFGTDFLT	5.0	3.0	-	-	3713_1:235577773-235577773 C>T_FKCRHPTGGSFICPNKVNFGTDFLT	0.0
1:46089512-46089512 C>T	1.0	4326	BREAST	-	-	-	-	CCDC17	uc009vxz.3,p.A24T|ENST00000528266,p.A24T|NM_001114938,p.A24T|ENST00000479529,p.A24T|ENST00000445048,p.A24T|ENST00000421127,p.A24T|ENST00000343901,p.A24T|uc010ols.2,p.A24T|NM_001190182,p.A24T|uc010olt.2,p.A24T|ENST00000372044,p.A24T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010olt.2	nonsynonymous SNV	exon1	c.G70A	p.A24T	PCGTCDMVFRSSALLATHTQRFCIG	PCGTCDMVFRSSTLLATHTQRFCIG	4.0	5.0	-	-	4326_1:46089512-46089512 C>T_PCGTCDMVFRSSTLLATHTQRFCIG	0.0
5:134705805-134705805 G>A	1.0	3713	MELANOMA	-	-	-	-	H2AFY	NM_001040158,p.A67V|uc003las.1,p.A67V|uc003lam.1,p.A67V|NM_138610,p.A67V|ENST00000510038,p.A67V|uc003lat.1,p.A67V|uc003lan.1,p.A67V|NM_138609,p.A67V|ENST00000506671,p.A67V|ENST00000304332,p.A67V|ENST00000511689,p.A67V|ENST00000312469,p.A67V|uc003lao.1,p.A67V|NM_004893,p.A67V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lat.1	nonsynonymous SNV	exon3	c.C200T	p.A67V	YLTAEILELAGNAARDNKKGRVTPR	YLTAEILELAGNVARDNKKGRVTPR	10.0	8.0	-	-	3713_5:134705805-134705805 G>A_YLTAEILELAGNVARDNKKGRVTPR	0.0
9:35403193-35403193 G>C	1.0	4126	NSCLC	-	-	-	-	UNC13B	NM_006377,p.V1423L|uc003zwq.3,p.V1423L|ENST00000378495,p.V1423L	protein_coding, processed_transcript	uc003zwq.3	nonsynonymous SNV	exon37	c.G4267C	p.V1423L	TQGSGVDDPVGEVSIQVDLFTHPGT	TQGSGVDDPVGELSIQVDLFTHPGT	5.0	10.0	-	-	4126_9:35403193-35403193 G>C_TQGSGVDDPVGELSIQVDLFTHPGT	0.0
4:126239730-126239730 G>T	0.0	4335	COLORECTAL	-	-	-	1	FAT4	ENST00000394329,p.G722C|NM_001291303,p.G722C|NM_024582,p.G722C|uc003ifj.4,p.G722C|NM_001291285,p.G722C	retained_intron, protein_coding	uc003ifj.4	nonsynonymous SNV	exon1	c.G2164T	p.G722C	TVSATDPDLGTNGTVKYSISAGDRS	TVSATDPDLGTNCTVKYSISAGDRS	5.0	5.0	-	-	4335_4:126239730-126239730 G>T_TVSATDPDLGTNCTVKYSISAGDRS	0.0
4:47939621-47939621 A>C	0.0	3903	MELANOMA	-	-	-	-	CNGA1	uc003gxu.3,p.I366S|ENST00000514170,p.I297S|ENST00000544810,p.I297S|ENST00000358519,p.I297S|NM_000087,p.I297S|NM_001142564,p.I366S|uc003gxt.4,p.I297S|ENST00000420489,p.I297S|ENST00000402813,p.I366S	retained_intron, protein_coding	uc003gxu.3	nonsynonymous SNV	exon10	c.T1097G	p.I366S	FQRTETRTNYPNIFRISNLVMYIVI	FQRTETRTNYPNSFRISNLVMYIVI	2.0	9.0	-	-	3903_4:47939621-47939621 A>C_FQRTETRTNYPNSFRISNLVMYIVI	0.0
5:127673796-127673796 C>T	0.0	4298	COLORECTAL	-	-	ID=COSM292256,COSM292257;OCCURENCE=1(large_intestine)	-	FBN2	ENST00000508053,p.R1164H|NM_001999,p.R1164H|ENST00000507835,p.R14H|ENST00000508989,p.R1131H|uc003kuu.3,p.R1164H|uc003kuv.2,p.R1131H|ENST00000262464,p.R1164H	retained_intron, protein_coding, processed_transcript	uc003kuv.2	nonsynonymous SNV	exon26	c.G3392A	p.R1131H	MMKNCMDIDECERNPLLCRGGTCVN	MMKNCMDIDECEHNPLLCRGGTCVN	2.0	10.0	-	-	4298_5:127673796-127673796 C>T_MMKNCMDIDECEHNPLLCRGGTCVN	0.0
18:57106810-57106810 C>T	0.0	3713	MELANOMA	-	-	-	-	CCBE1	ENST00000398179,p.G35S|uc010dpq.3,p.G35S	retained_intron, protein_coding	uc010dpq.3	nonsynonymous SNV	exon3	c.G103A	p.G35S	DLLACLGARALPGPPGAPGRDGSKG	DLLACLGARALPSPPGAPGRDGSKG	2.0	1.0	-	-	3713_18:57106810-57106810 C>T_DLLACLGARALPSPPGAPGRDGSKG	0.0
13:21563290-21563290 G>A	1.0	2556	MELANOMA	-	-	-	-	LATS2	uc001unr.4,p.P210L|ENST00000382592,p.P210L|ENST00000542899,p.P210L|uc009zzs.3,p.P210L|NM_014572,p.P210L	protein_coding, processed_transcript	uc009zzs.3	nonsynonymous SNV	exon4	c.C629T	p.P210L	ADGPTALEEMPRPYVDYLFPGVGPH	ADGPTALEEMPRLYVDYLFPGVGPH	9.0	5.0	-	-	2556_13:21563290-21563290 G>A_ADGPTALEEMPRLYVDYLFPGVGPH	0.0
6:32117436-32117436 C>T	0.0	4189	MELANOMA	-	-	-	-	PRRT1	NM_030651,p.G208S|ENST00000375152,p.G127S|ENST00000375150,p.G127S|uc003nzt.3,p.G208S|uc003nzs.3,p.G249S|ENST00000211413,p.G208S	retained_intron, protein_coding, processed_transcript	uc003nzt.3	nonsynonymous SNV	exon3	c.G622A	p.G208S	TGVTSTLPPPPQGPGLALLEPRRPP	TGVTSTLPPPPQSPGLALLEPRRPP	5.0	6.0	-	-	4189_6:32117436-32117436 C>T_TGVTSTLPPPPQSPGLALLEPRRPP	0.0
22:29279984-29279988 ACACC>-	1.0	4160	COLORECTAL	-	-	-	2	ZNRF3	uc003aeg.3,p.Y77fs|NM_001206998,p.Y77fs|ENST00000544604,p.Y77fs	protein_coding	uc003aeg.3	frameshift deletion	exon1	c.230_234del	p.Y77fs	LFESSPSGDYTTYTTGLTGRFSRAG	LFESSPSGDYTTYRPHGPLLAGRGHAQRRGRDRADAPTGPM	7.0	9.0	-	-	4160_22:29279984-29279988 ACACC>-_LFESSPSGDYTTYRPHGPLLAGRGHAQRRGRDRADAPTGPM	0.0
9:104432734-104432734 C>A	0.0	4278	COLORECTAL	-	-	ID=COSM1553817;OCCURENCE=1(lung)	-	GRIN3A	ENST00000361820,p.G654C|uc004bbp.2,p.G654C|uc004bbq.1,p.G654C|NM_133445,p.G654C	protein_coding, processed_transcript	uc004bbq.1	nonsynonymous SNV	exon3	c.G1960T	p.G654C	IDFTSPFFSTSLGILVRTRDTAAPI	IDFTSPFFSTSLCILVRTRDTAAPI	2.0	8.0	-	-	4278_9:104432734-104432734 C>A_IDFTSPFFSTSLCILVRTRDTAAPI	0.0
2:26501592-26501592 G>C	1.0	4244	COLORECTAL	-	-	ID=COSM1306644;OCCURENCE=1(urinary_tract)	-	HADHB	NM_000183,p.D185H|NM_001281513,p.D163H|ENST00000537713,p.D170H|uc002rgz.3,p.D185H|uc010ykx.2,p.D111H|uc010ykw.2,p.D170H|ENST00000545822,p.D163H|uc010ykv.2,p.D163H|ENST00000317799,p.D185H|NM_001281512,p.D170H	retained_intron, protein_coding, processed_transcript	uc010ykx.2	nonsynonymous SNV	exon4	c.G331C	p.D111H	IRHSRKMRKLMLDLNKAKSMGQRLS	IRHSRKMRKLMLHLNKAKSMGQRLS	10.0	4.0	-	-	4244_2:26501592-26501592 G>C_IRHSRKMRKLMLHLNKAKSMGQRLS	0.0
8:67062045-67062045 A>T	0.0	4266	COLORECTAL	-	-	-	-	TRIM55	uc003xvu.3,p.N257Y|ENST00000276573,p.N257Y|uc003xvw.3,p.N257Y|NM_184085,p.N257Y|NM_033058,p.N257Y|uc003xvv.3,p.N257Y|NM_184086,p.N257Y|ENST00000353317,p.N257Y|ENST00000315962,p.N257Y	retained_intron, protein_coding	uc003xvw.3	nonsynonymous SNV	exon5	c.A769T	p.N257Y	RALIKKYSDHLENVSKLVESGIQFM	RALIKKYSDHLEYVSKLVESGIQFM	4.0	9.0	-	-	4266_8:67062045-67062045 A>T_RALIKKYSDHLEYVSKLVESGIQFM	0.0
X:114427080-114427080 C>T	0.0	4110	BILE DUCT	-	-	-	-	RBMXL3	ENST00000424776,p.P1026S|uc011mte.1,p.P1026S|NM_001145346,p.P1026S	protein_coding	uc011mte.1	nonsynonymous SNV	exon1	c.C3076T	p.P1026S	GRDRVGRPDRGLPLPMETGSPPLHD	GRDRVGRPDRGLSLPMETGSPPLHD	1.0	5.0	-	-	4110_X:114427080-114427080 C>T_GRDRVGRPDRGLSLPMETGSPPLHD	0.0
X:24732688-24732688 C>T	0.0	4245	COLORECTAL	-	-	-	-	POLA1	uc004dbl.3,p.R116C|uc004dbm.3,p.R122C|ENST00000379068,p.R122C|NM_016937,p.R116C|ENST00000379059,p.R116C	protein_coding, processed_transcript	uc004dbm.3	nonsynonymous SNV	exon5	c.C364T	p.R122C	LDADEKGKDGKARNKDKRNVKKLAV	LDADEKGKDGKACNKDKRNVKKLAV	8.0	7.0	-	-	4245_X:24732688-24732688 C>T_LDADEKGKDGKACNKDKRNVKKLAV	0.0
1:11889363-11889363 A>G	1.0	4335	COLORECTAL	-	-	ID=COSM3801450;OCCURENCE=1(breast)	-	CLCN6	NM_001256959,p.D389G|ENST00000376487,p.D389G|uc010oat.3,p.D127G|NM_001286,p.D411G|ENST00000376496,p.D411G|uc001ate.5,p.D411G|ENST00000346436,p.D411G|uc010oau.3,p.D389G	protein_coding, processed_transcript	uc010oau.3	nonsynonymous SNV	exon12	c.A1166G	p.D389G	CRQMSSSSQIGNDSFQLQVTEDVNS	CRQMSSSSQIGNGSFQLQVTEDVNS	7.0	6.0	-	-	4335_1:11889363-11889363 A>G_CRQMSSSSQIGNGSFQLQVTEDVNS	0.0
6:62407100-62407100 C>T	0.0	4287	COLORECTAL	-	-	-	-	KHDRBS2	ENST00000281156,p.A318T|uc003peg.2,p.A318T|NM_152688,p.A318T	protein_coding	uc003peg.2	nonsynonymous SNV	exon8	c.G952A	p.A318T	GHGVSEDAYDSYAPEEWATTRSSLK	GHGVSEDAYDSYTPEEWATTRSSLK	3.0	10.0	-	-	4287_6:62407100-62407100 C>T_GHGVSEDAYDSYTPEEWATTRSSLK	0.0
16:29756005-29756005 C>T	0.0	4238	COLORECTAL	-	-	-	-	C16orf54	ENST00000329410,p.E90K|uc002dtp.2,p.E90K|NM_175900,p.E90K	protein_coding	uc002dtp.2	nonsynonymous SNV	exon2	c.G268A	p.E90K	GELWIEPMGTARERSEDWYGSAVPL	GELWIEPMGTARKRSEDWYGSAVPL	2.0	10.0	-	-	4238_16:29756005-29756005 C>T_GELWIEPMGTARKRSEDWYGSAVPL	0.0
5:176024176-176024176 G>A	1.0	3784	MELANOMA	-	-	-	-	GPRIN1	NM_052899,p.P887L|uc021yif.1,p.P887L|uc003meo.1,p.P887L|ENST00000303991,p.P887L	protein_coding	uc021yif.1	nonsynonymous SNV	exon1	c.C2660T	p.P887L	PMTPQAAAPPAFPEVRVRPGSALAA	PMTPQAAAPPAFLEVRVRPGSALAA	5.0	8.0	-	-	3784_5:176024176-176024176 G>A_PMTPQAAAPPAFLEVRVRPGSALAA	0.0
17:78081609-78081609 A>G	1.0	4180	BREAST	-	-	-	-	GAA	ENST00000390015,p.N290S|NM_001079803,p.N290S|uc002jxq.3,p.N290S|uc002jxp.3,p.N290S|NM_001079804,p.N290S|uc002jxo.3,p.N290S|NM_000152,p.N290S|ENST00000302262,p.N290S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002jxq.3	nonsynonymous SNV	exon5	c.A869G	p.N290S	LWNRDLAPTPGANLYGSHPFYLALE	LWNRDLAPTPGASLYGSHPFYLALE	10.0	7.0	CD8	-	4180_17:78081609-78081609 A>G_LWNRDLAPTPGASLYGSHPFYLALE	2.0
1:36316576-36316576 C>T	1.0	3466	MELANOMA	-	-	-	-	AGO4	ENST00000373210,p.S800F|NM_017629,p.S800F|uc001bzj.2,p.S800F	protein_coding, processed_transcript	uc001bzj.2	nonsynonymous SNV	exon17	c.C2399T	p.S800F	LCHTYVRCTRSVSIPAPAYYARLVA	LCHTYVRCTRSVFIPAPAYYARLVA	6.0	7.0	-	-	3466_1:36316576-36316576 C>T_LCHTYVRCTRSVFIPAPAYYARLVA	0.0
12:52374773-52374773 C>T	1.0	4196	COLORECTAL	-	-	-	-	ACVR1B	uc001rzm.3,p.R201C|ENST00000415850,p.R201C|ENST00000426655,p.R201C|NM_020327,p.R149C|uc001rzn.3,p.R201C|ENST00000542485,p.R149C|uc010snn.2,p.R201C|uc021qya.1,p.R149C|ENST00000257963,p.R201C|NM_004302,p.R201C|NM_020328,p.R201C|ENST00000541224,p.R201C|uc001rzl.3,p.R201C	protein_coding, processed_transcript, nonsense_mediated_decay	uc021qya.1	nonsynonymous SNV	exon4	c.C445T	p.R149C	SGSGSGLPLFVQRTVARTIVLQEII	SGSGSGLPLFVQCTVARTIVLQEII	9.0	6.0	-	-	4196_12:52374773-52374773 C>T_SGSGSGLPLFVQCTVARTIVLQEII	0.0
X:47774736-47774736 T>G	0.0	4177	PANCREATIC	-	-	-	-	ZNF81	uc010nhy.2,p.S231A|ENST00000376954,p.S231A|NM_007137,p.S231A|uc022bvq.1,p.S231A|ENST00000338637,p.S231A	protein_coding, processed_transcript	uc022bvq.1	nonsynonymous SNV	exon5	c.T691G	p.S231A	KTIGHGQVFTQNSSYSHHENTHTGV	KTIGHGQVFTQNASYSHHENTHTGV	6.0	1.0	-	-	4177_X:47774736-47774736 T>G_KTIGHGQVFTQNASYSHHENTHTGV	0.0
1:207134283-207134283 G>A	0.0	3795	MELANOMA	-	-	-	-	FCAMR	NM_001170631,p.P313L|uc001hfa.4,p.P313L|uc021pig.1,p.P228L|ENST00000324852,p.P313L	protein_coding, processed_transcript, nonsense_mediated_decay	uc021pig.1	nonsynonymous SNV	exon3	c.C683T	p.P228L	SVKAPAPIPESPPSKSRSMSNTTEG	SVKAPAPIPESPLSKSRSMSNTTEG	1.0	7.0	-	-	3795_1:207134283-207134283 G>A_SVKAPAPIPESPLSKSRSMSNTTEG	0.0
6:148848652-148848652 C>T	1.0	3466	MELANOMA	-	-	-	-	SASH1	NM_015278,p.L450F|uc003qme.1,p.L450F|ENST00000367467,p.L450F|uc011eeb.1,p.L211F	protein_coding, processed_transcript	uc011eeb.1	nonsynonymous SNV	exon5	c.C631T	p.L211F	EVIKSPTASRISLGKKVKSVKETMR	EVIKSPTASRISFGKKVKSVKETMR	8.0	9.0	-	-	3466_6:148848652-148848652 C>T_EVIKSPTASRISFGKKVKSVKETMR	0.0
10:46967469-46967469 C>T	0.0	4259	COLORECTAL	-	-	ID=COSM1347897,COSM1347898,COSM1347896;OCCURENCE=1(large_intestine)	-	SYT15	ENST00000374323,p.R256H|ENST00000503753,p.R203H|ENST00000512997,p.R87H|uc001jeb.3,p.R81H|uc001jea.3,p.R203H|ENST00000374325,p.R203H|NM_031912,p.R203H|ENST00000374321,p.R203H|NM_181519,p.R203H|uc001jdz.2,p.R203H	protein_coding, processed_transcript	uc001jeb.3	nonsynonymous SNV	exon3	c.G242A	p.R81H	PDERRFLQSKTKRKTSNPQFDEHFI	PDERRFLQSKTKHKTSNPQFDEHFI	6.0	5.0	-	-	4259_10:46967469-46967469 C>T_PDERRFLQSKTKHKTSNPQFDEHFI	0.0
17:33690684-33690684 C>T	1.0	4234	NSCLC	-	-	-	-	SLFN11	ENST00000588579,p.R48Q|uc010ctp.3,p.R48Q|NM_001104588,p.R48Q|NM_001104589,p.R48Q|uc002hjg.4,p.R48Q|NM_152270,p.R48Q|ENST00000591682,p.R48Q|uc002hjh.4,p.R48Q|ENST00000589811,p.R48Q|ENST00000394566,p.R48Q|ENST00000441608,p.R48Q|ENST00000427966,p.R48Q|ENST00000430814,p.R48Q|uc010ctr.3,p.R48Q|NM_001104587,p.R48Q|NM_001104590,p.R48Q|ENST00000308377,p.R48Q|uc010ctq.3,p.R48Q	retained_intron, protein_coding	uc010ctr.3	nonsynonymous SNV	exon3	c.G143A	p.R48Q	KIQRDQEKERVMRAACALLNSGGGV	KIQRDQEKERVMQAACALLNSGGGV	9.0	5.0	CD8	-	4234_17:33690684-33690684 C>T_KIQRDQEKERVMQAACALLNSGGGV	1.0
12:117612137-117612137 G>T	1.0	3678	MELANOMA	-	-	-	-	FBXO21	NM_015002,p.S250Y|uc009zwq.3,p.S250Y|NM_033624,p.S250Y|ENST00000427718,p.S250Y|uc001twj.3,p.S250Y|uc001twk.3,p.S250Y|ENST00000330622,p.S250Y	protein_coding, processed_transcript	uc009zwq.3	nonsynonymous SNV	exon6	c.C749A	p.S250Y	RHPSLAFKAGESSMIMEIELQSQVL	RHPSLAFKAGESYMIMEIELQSQVL	9.0	5.0	CD8	-	3678_12:117612137-117612137 G>T_RHPSLAFKAGESYMIMEIELQSQVL	1.0
12:55968382-55968382 C>T	0.0	4287	COLORECTAL	-	-	ID=COSM3384499;OCCURENCE=1(pancreas)	-	OR2AP1	uc031qhr.1,p.R62W|NM_001258285,p.R62W|ENST00000321688,p.R62W	protein_coding	uc031qhr.1	nonsynonymous SNV	exon1	c.C184T	p.R62W	DSHLQTPMYFFLRNFSFLEISFTNI	DSHLQTPMYFFLWNFSFLEISFTNI	1.0	9.0	-	-	4287_12:55968382-55968382 C>T_DSHLQTPMYFFLWNFSFLEISFTNI	0.0
1:62740093-62740093 A>T	0.0	3903	MELANOMA	-	-	-	-	KANK4	NM_181712,p.V228D|ENST00000371153,p.V228D|uc001dah.4,p.V228D	protein_coding	uc001dah.4	nonsynonymous SNV	exon3	c.T683A	p.V228D	SSPRASTRIPELVQEGAEPPEGVVK	SSPRASTRIPELDQEGAEPPEGVVK	1.0	9.0	-	-	3903_1:62740093-62740093 A>T_SSPRASTRIPELDQEGAEPPEGVVK	0.0
2:74760778-74760778 C>G	0.0	4186	BREAST	-	-	-	-	LOXL3	NM_032603,p.R739S|uc010ffm.1,p.R683S|ENST00000264094,p.R739S|uc002smq.1,p.R594S|ENST00000409549,p.R683S|NM_001289165,p.R378S|ENST00000393937,p.R594S|uc002smp.1,p.R739S|ENST00000409249,p.R457S|uc002smo.1,p.R378S|NM_001289164,p.R594S	retained_intron, protein_coding, processed_transcript	uc010ffm.1	nonsynonymous SNV	exon12	c.G2049C	p.R683S	CHIGDAFSEEANRRFERYPGQTSNQ	CHIGDAFSEEANSRFERYPGQTSNQ	7.0	8.0	-	-	4186_2:74760778-74760778 C>G_CHIGDAFSEEANSRFERYPGQTSNQ	0.0
4:109670467-109670467 G>A	1.0	4266	COLORECTAL	-	-	-	-	ETNPPL	NM_031279,p.P285L|uc011cfo.2,p.P227L|ENST00000411864,p.P279L|ENST00000296486,p.P285L|ENST00000510706,p.P245L|uc010imc.3,p.P279L|uc011cfm.2,p.P245L|uc011cfn.2,p.P212L|NM_001146590,p.P279L|uc003hzc.3,p.P285L|ENST00000512646,p.P227L|NM_001146627,p.P227L	retained_intron, protein_coding, nonsense_mediated_decay	uc011cfo.2	nonsynonymous SNV	exon7	c.C680T	p.P227L	IVTMGKPMGNGHPVACVVTTKEIAE	IVTMGKPMGNGHLVACVVTTKEIAE	2.0	5.0	-	-	4266_4:109670467-109670467 G>A_IVTMGKPMGNGHLVACVVTTKEIAE	0.0
11:46914534-46914534 G>A	1.0	2369	MELANOMA	-	-	-	-	LRP4	NM_002334,p.P563S|uc001ndn.4,p.P563S|ENST00000378623,p.P563S	retained_intron, protein_coding	uc001ndn.4	nonsynonymous SNV	exon13	c.C1687T	p.P563S	QNLEKPRAIALHPMEGTIYWTDWGN	QNLEKPRAIALHSMEGTIYWTDWGN	7.0	3.0	-	-	2369_11:46914534-46914534 G>A_QNLEKPRAIALHSMEGTIYWTDWGN	0.0
3:52802401-52802401 C>G	1.0	4134	NSCLC	-	-	-	-	NEK4	ENST00000233027,p.E105Q|uc003dfr.3,p.E105Q|uc003dfq.4,p.E105Q|ENST00000383721,p.E105Q|NM_003157,p.E105Q	retained_intron, protein_coding, nonsense_mediated_decay	uc003dfr.3	nonsynonymous SNV	exon2	c.G313C	p.E105Q	RKLKEQKGQLLPENQVVEWFVQIAM	RKLKEQKGQLLPQNQVVEWFVQIAM	6.0	10.0	-	-	4134_3:52802401-52802401 C>G_RKLKEQKGQLLPQNQVVEWFVQIAM	0.0
1:32842145-32842145 G>A	1.0	3466	MELANOMA	-	-	-	-	BSDC1	uc001bvj.3,p.P188S|NM_001300958,p.P309S|NM_001143889,p.P236S|ENST00000526031,p.P197S|ENST00000444377,p.P292S|uc010ohg.2,p.P309S|ENST00000446293,p.P309S|ENST00000419121,p.P236S|uc001bvh.4,p.P292S|ENST00000413080,p.P231S|ENST00000341071,p.P309S|NM_001143890,p.P197S|uc010ohh.2,p.P236S|NM_018045,p.P292S|ENST00000455895,p.P292S|uc010ohi.2,p.P197S|ENST00000449308,p.P292S|uc001bvi.3,p.P309S|NM_001143888,p.P309S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ohi.2	nonsynonymous SNV	exon7	c.C589T	p.P197S	SESISLVTQIANPATAPEARVLPKD	SESISLVTQIANSATAPEARVLPKD	9.0	3.0	-	-	3466_1:32842145-32842145 G>A_SESISLVTQIANSATAPEARVLPKD	0.0
7:99654690-99654690 G>A	1.0	4252	COLORECTAL	-	-	-	-	ZSCAN21	NM_145914,p.V21M|uc003usn.1,p.V20M|ENST00000292450,p.V21M|ENST00000543588,p.V21M|uc011kje.1,p.V20M|ENST00000438937,p.V21M|uc003uso.3,p.V21M|ENST00000456748,p.V21M	protein_coding, processed_transcript	uc011kje.1	nonsynonymous SNV	exon3	c.G58A	p.V20M	APVLGPRPPQEQVGPLMVKVEEKEE	APVLGPRPPQEQMGPLMVKVEEKEE	7.0	9.0	-	-	4252_7:99654690-99654690 G>A_APVLGPRPPQEQMGPLMVKVEEKEE	0.0
5:140589779-140589779 G>A	1.0	4078	GASTRIC	-	-	-	-	PCDHB12	ENST00000541609,p.E97K|uc003liz.3,p.E434K|uc011dak.2,p.E97K|ENST00000239450,p.E434K|NM_018932,p.E434K	protein_coding	uc011dak.2	nonsynonymous SNV	exon2	c.G289A	p.E97K	TVTDLGTPRLKTEHNITVLVSDVND	TVTDLGTPRLKTKHNITVLVSDVND	3.0	4.0	-	-	4078_5:140589779-140589779 G>A_TVTDLGTPRLKTKHNITVLVSDVND	0.0
9:35403193-35403193 G>C	1.0	4126	NSCLC	-	-	-	-	UNC13B	ENST00000378496,p.V1442L|ENST00000396787,p.V1454L|uc003zwr.3,p.V1442L	protein_coding, processed_transcript	uc003zwr.3	nonsynonymous SNV	exon38	c.G4324C	p.V1442L	EKGSGVDDPVGEVSIQVDLFTHPGT	EKGSGVDDPVGELSIQVDLFTHPGT	5.0	10.0	-	-	4126_9:35403193-35403193 G>C_EKGSGVDDPVGELSIQVDLFTHPGT	0.0
19:58926993-58926993 C>G	0.0	4335	COLORECTAL	-	-	-	-	ZNF584	uc002qsp.3,p.A91G|ENST00000306910,p.A91G|ENST00000593920,p.A46G|NM_173548,p.A91G	retained_intron, protein_coding, processed_transcript	uc002qsp.3	nonsynonymous SNV	exon3	c.C272G	p.A91G	SWVDVTPVSRAEARRGFGLDGLCRV	SWVDVTPVSRAEGRRGFGLDGLCRV	5.0	4.0	-	-	4335_19:58926993-58926993 C>G_SWVDVTPVSRAEGRRGFGLDGLCRV	0.0
1:151288233-151288233 G>A	1.0	3466	MELANOMA	-	-	-	-	PI4KB	uc001exu.3,p.S242L|ENST00000368874,p.S242L|NM_001198773,p.S242L|NM_001198774,p.S242L|ENST00000368873,p.S242L|uc001exs.3,p.S242L|ENST00000368872,p.S242L|ENST00000271657,p.S254L|ENST00000368875,p.S254L|uc001exr.3,p.S254L|NM_002651,p.S254L|uc001ext.3,p.S242L|ENST00000438243,p.S242L	retained_intron, protein_coding	uc001exu.3	nonsynonymous SNV	exon2	c.C725T	p.S242L	HSRGTKLRKLILSDELKPAHRKREL	HSRGTKLRKLILLDELKPAHRKREL	10.0	2.0	-	-	3466_1:151288233-151288233 G>A_HSRGTKLRKLILLDELKPAHRKREL	0.0
2:43814072-43814072 T>G	0.0	4238	COLORECTAL	-	-	-	-	THADA	uc002rtb.2,p.E124D|ENST00000474159,p.E124D|ENST00000405975,p.E124D|ENST00000402360,p.E124D|uc002rtc.4,p.E124D|ENST00000404790,p.E124D|NM_001271643,p.E124D|uc002rsw.4,p.E124D|NM_001083953,p.E124D|uc002rtd.3,p.E124D|NM_022065,p.E124D|ENST00000405006,p.E124D|ENST00000398653,p.E124D|NM_001271644,p.E124D|uc002rsx.4,p.E124D|ENST00000403856,p.E124D|ENST00000408045,p.E124D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rtd.3	nonsynonymous SNV	exon6	c.A372C	p.E124D	PEAMHRFTSRLQEELNTTDLYSYRK	PEAMHRFTSRLQDELNTTDLYSYRK	9.0	1.0	-	-	4238_2:43814072-43814072 T>G_PEAMHRFTSRLQDELNTTDLYSYRK	0.0
4:142053787-142053787 G>A	0.0	4258	ENDOMETRIAL	-	-	-	-	RNF150	uc003iio.1,p.A59V|ENST00000306799,p.A59V|uc010iok.1,p.A59V|ENST00000507500,p.A59V|NM_020724,p.A59V|ENST00000515673,p.A59V|uc003iip.1,p.A59V	protein_coding, processed_transcript	uc010iok.1	nonsynonymous SNV	exon1	c.C176T	p.A59V	TYAEPAPDPGAGAAGGGGAELHTEK	TYAEPAPDPGAGVAGGGGAELHTEK	6.0	3.0	-	-	4258_4:142053787-142053787 G>A_TYAEPAPDPGAGVAGGGGAELHTEK	0.0
X:44918698-44918698 T>G	1.0	4177	PANCREATIC	-	-	-	1	KDM6A	uc022bvj.1,p.I394S|uc011mla.2,p.I394S|uc022bvi.1,p.I143S|NM_001291417,p.I394S|NM_001291418,p.I394S|ENST00000536777,p.I394S|uc011mlc.2,p.I143S|NM_001291421,p.I143S|ENST00000543216,p.I394S	protein_coding, processed_transcript	uc022bvj.1	nonsynonymous SNV	exon12	c.T1181G	p.I394S	KSCSNTSALAARIKYLQNTSDNWSG	KSCSNTSALAARSKYLQNTSDNWSG	7.0	10.0	-	-	4177_X:44918698-44918698 T>G_KSCSNTSALAARSKYLQNTSDNWSG	0.0
20:62122077-62122077 C>T	1.0	3919	MELANOMA	-	-	-	-	EEF1A2	NM_001958,p.V262M|uc002yfe.2,p.V262M|ENST00000298049,p.V262M|ENST00000217182,p.V262M	protein_coding	uc002yfe.2	nonsynonymous SNV	exon6	c.G784A	p.V262M	LQDVYKIGGIGTVPVGRVETGILRP	LQDVYKIGGIGTMPVGRVETGILRP	1.0	6.0	-	-	3919_20:62122077-62122077 C>T_LQDVYKIGGIGTMPVGRVETGILRP	0.0
13:77570260-77570260 C>T	1.0	3713	MELANOMA	-	-	-	-	CLN5	uc001vkc.3,p.S237L|ENST00000377453,p.S237L|NM_006493,p.S237L	protein_coding, processed_transcript	uc001vkc.3	nonsynonymous SNV	exon3	c.C710T	p.S237L	KENGTLVQVATISGNMFNQMAKWVK	KENGTLVQVATILGNMFNQMAKWVK	8.0	8.0	-	-	3713_13:77570260-77570260 C>T_KENGTLVQVATILGNMFNQMAKWVK	0.0
6:73843311-73843311 G>A	0.0	4287	COLORECTAL	-	-	-	-	KCNQ5	NM_001160132,p.R482H|uc011dyi.2,p.R482H|NM_001160130,p.R463H|ENST00000355635,p.R473H|ENST00000403813,p.R463H|ENST00000370398,p.R472H|uc011dyh.2,p.R491H|ENST00000355194,p.R472H|ENST00000342056,p.R491H|NM_019842,p.R472H|uc010kat.3,p.R463H|uc011dyk.2,p.R222H|ENST00000402622,p.R482H|NM_001160133,p.R491H|uc003pgk.3,p.R472H	protein_coding	uc011dyk.2	nonsynonymous SNV	exon8	c.G665A	p.R222H	KVQKSWSFNDRTRFRPSLRLKSSQP	KVQKSWSFNDRTHFRPSLRLKSSQP	3.0	10.0	-	-	4287_6:73843311-73843311 G>A_KVQKSWSFNDRTHFRPSLRLKSSQP	0.0
X:72434217-72434217 C>T	0.0	4240	BREAST	-	-	-	-	NAP1L2	uc004ebi.3,p.A38T|ENST00000373517,p.A38T|NM_021963,p.A38T	protein_coding	uc004ebi.3	nonsynonymous SNV	exon1	c.G112A	p.A38T	GLGEHLERGEDAAAGLGDDGKCGEE	GLGEHLERGEDATAGLGDDGKCGEE	3.0	10.0	-	-	4240_X:72434217-72434217 C>T_GLGEHLERGEDATAGLGDDGKCGEE	0.0
22:24108324-24108324 A>G	1.0	4180	BREAST	-	-	-	-	CHCHD10	uc002zxw.3,p.Y134H|NM_001301339,p.Y141H|ENST00000484558,p.Y134H|ENST00000401675,p.Y141H|NM_213720,p.Y134H	retained_intron, protein_coding, nonsense_mediated_decay	uc002zxw.3	nonsynonymous SNV	exon3	c.T400C	p.Y134H	CEGFSEALKQCKYYHGLSSLP	CEGFSEALKQCKHYHGLSSLP	10.0	3.0	-	-	4180_22:24108324-24108324 A>G_CEGFSEALKQCKHYHGLSSLP	0.0
16:68901008-68901008 G>C	1.0	4317	COLORECTAL	-	-	-	-	TANGO6	uc002ewh.3,p.M293I|ENST00000261778,p.M293I|NM_024562,p.M293I|uc002ewi.4,p.M293I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ewi.4	nonsynonymous SNV	exon4	c.G879C	p.M293I	GPPQSCTDVKTQMRCRAPAWLRRLC	GPPQSCTDVKTQIRCRAPAWLRRLC	7.0	8.0	-	-	4317_16:68901008-68901008 G>C_GPPQSCTDVKTQIRCRAPAWLRRLC	0.0
1:46978026-46978026 T>C	0.0	4301	MELANOMA	-	-	-	-	DMBX1	NM_147192,p.S337P|ENST00000371956,p.S337P|ENST00000360032,p.S332P|uc001cpx.3,p.S337P|uc001cpw.3,p.S332P|NM_172225,p.S332P	protein_coding	uc001cpx.3	nonsynonymous SNV	exon4	c.T1009C	p.S337P	SAAAAAHQGVWGSPLLPAPPAGLAP	SAAAAAHQGVWGPPLLPAPPAGLAP	1.0	3.0	-	-	4301_1:46978026-46978026 T>C_SAAAAAHQGVWGPPLLPAPPAGLAP	0.0
9:118949838-118949838 C>A	0.0	3919	MELANOMA	-	-	-	-	PAPPA	uc011lxq.2,p.T67N|ENST00000328252,p.T274N|uc004bjn.3,p.T274N|uc011lxp.1,p.T67N|NM_002581,p.T274N	protein_coding, processed_transcript	uc011lxq.2	nonsynonymous SNV	exon1	c.C200A	p.T67N	ARTQREILSDMETHGAHTALPQLLL	ARTQREILSDMENHGAHTALPQLLL	4.0	10.0	-	-	3919_9:118949838-118949838 C>A_ARTQREILSDMENHGAHTALPQLLL	0.0
1:227834345-227834345 A>G	1.0	4335	COLORECTAL	-	-	-	-	ZNF678	ENST00000440339,p.E75G|NM_178549,p.E75G|ENST00000397097,p.E75G|uc021pjy.1,p.E75G	protein_coding, processed_transcript	uc021pjy.1	nonsynonymous SNV	exon3	c.A224G	p.E75G	PAQRNLYRDVMFENYRNLVSLAILS	PAQRNLYRDVMFGNYRNLVSLAILS	10.0	2.0	-	-	4335_1:227834345-227834345 A>G_PAQRNLYRDVMFGNYRNLVSLAILS	0.0
5:140720480-140720480 G>A	1.0	3713	MELANOMA	-	-	-	-	PCDHGA2	uc011dao.2,p.D648N|NM_018915,p.D648N|NM_032009,p.D648N|uc003ljk.2,p.D648N|ENST00000394576,p.D648N	retained_intron, protein_coding	uc011dao.2	nonsynonymous SNV	exon1	c.G1942A	p.D648N	DALKQSLVVAIQDHGQPPLSATVTL	DALKQSLVVAIQNHGQPPLSATVTL	3.0	8.0	-	-	3713_5:140720480-140720480 G>A_DALKQSLVVAIQNHGQPPLSATVTL	0.0
2:238277697-238277697 G>T	0.0	4287	COLORECTAL	-	-	-	-	COL6A3	NM_057167,p.P1264H|uc002vwl.2,p.P1470H|ENST00000353578,p.P1264H|ENST00000295550,p.P1470H|NM_057166,p.P863H|ENST00000346358,p.P1270H|ENST00000472056,p.P863H|ENST00000347401,p.P1269H|NM_004369,p.P1470H|uc010znj.1,p.P863H|uc002vwo.2,p.P1264H|ENST00000409809,p.P1264H	retained_intron, protein_coding, processed_transcript	uc010znj.1	nonsynonymous SNV	exon7	c.C2588A	p.P863H	FVSRIVRRLNIGPSKVRVGVVQFSN	FVSRIVRRLNIGHSKVRVGVVQFSN	9.0	8.0	-	-	4287_2:238277697-238277697 G>T_FVSRIVRRLNIGHSKVRVGVVQFSN	0.0
17:37340361-37340361 G>A	1.0	3919	MELANOMA	-	-	-	-	CACNB1	uc002hrn.3,p.S274F|uc002hro.3,p.S319F|ENST00000394310,p.S274F|ENST00000344140,p.S319F|uc002hrl.1,p.S46F|NM_199247,p.S319F|uc002hrm.2,p.S274F|NM_199248,p.S274F|ENST00000394303,p.S274F|NM_000723,p.S274F	retained_intron, protein_coding, processed_transcript	uc002hro.3	nonsynonymous SNV	exon10	c.C956T	p.S319F	GRISITRVTADISLAKRSVLNNPSK	GRISITRVTADIFLAKRSVLNNPSK	4.0	9.0	-	-	3919_17:37340361-37340361 G>A_GRISITRVTADIFLAKRSVLNNPSK	0.0
10:131666141-131666141 C>T	0.0	3795	MELANOMA	-	-	ID=COSM1250898,COSM1250897;OCCURENCE=1(oesophagus)	-	EBF3	uc021qav.2,p.G264S|uc001lki.2,p.G264S|NM_001005463,p.G264S|ENST00000368648,p.G264S|ENST00000355311,p.G273S	protein_coding, processed_transcript	uc021qav.2	nonsynonymous SNV	exon9	c.G790A	p.G264S	ATPCIKAISPSEGWTTGGATVIIIG	ATPCIKAISPSESWTTGGATVIIIG	3.0	9.0	-	-	3795_10:131666141-131666141 C>T_ATPCIKAISPSESWTTGGATVIIIG	0.0
10:7708773-7708773 G>A	0.0	4196	COLORECTAL	-	-	-	-	ITIH5	uc001ijr.2,p.S28L|uc021pmv.1,p.S28L|ENST00000256861,p.S28L|ENST00000397146,p.S28L|NM_001001851,p.S28L|ENST00000397145,p.S28L|NM_030569,p.S28L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pmv.1	nonsynonymous SNV	exon1	c.C83T	p.S28L	GSQEEAQSWGHSSEQDGLRVPRQVR	GSQEEAQSWGHSLEQDGLRVPRQVR	6.0	8.0	-	-	4196_10:7708773-7708773 G>A_GSQEEAQSWGHSLEQDGLRVPRQVR	0.0
21:17220076-17220076 ->G	0.0	4320	COLORECTAL	-	-	-	-	USP25	ENST00000400183,p.E811fs|uc011aby.1,p.E811fs|NM_001283041,p.E811fs	retained_intron, protein_coding, processed_transcript	uc011aby.1	frameshift insertion	exon19	c.2433dupG	p.E811fs	IPHVGKFMIESKEGGYDDEIMMTPN	IPHVGKFMIESKEGGV	8.0	3.0	-	-	4320_21:17220076-17220076 ->G_IPHVGKFMIESKEGGV	0.0
5:176468821-176468821 C>T	1.0	3784	MELANOMA	-	-	-	-	ZNF346	ENST00000511834,p.H108Y|uc003mfi.3,p.H108Y|ENST00000503039,p.H133Y|uc003mfk.1,p.H133Y|NM_012279,p.H108Y|ENST00000513587,p.H108Y|ENST00000508155,p.H108Y|ENST00000261948,p.H133Y|ENST00000358149,p.H108Y	retained_intron, protein_coding, nonsense_mediated_decay	uc003mfk.1	nonsynonymous SNV	exon4	c.C397T	p.H133Y	KHANKVKRYLAIHGMETLKGETKKL	KHANKVKRYLAIYGMETLKGETKKL	6.0	5.0	-	-	3784_5:176468821-176468821 C>T_KHANKVKRYLAIYGMETLKGETKKL	0.0
17:77768943-77768943 C>A	0.0	4189	MELANOMA	-	-	-	-	CBX8	ENST00000413392,p.G211C|uc002jxd.2,p.G221C|ENST00000269385,p.G221C|NM_020649,p.G221C	protein_coding, processed_transcript	uc002jxd.2	nonsynonymous SNV	exon5	c.G661T	p.G221C	DPSQRPLGEPSAGLGEYLKGRKLDD	DPSQRPLGEPSACLGEYLKGRKLDD	4.0	8.0	-	-	4189_17:77768943-77768943 C>A_DPSQRPLGEPSACLGEYLKGRKLDD	0.0
19:39663943-39663943 C>T	1.0	4275	COLORECTAL	-	-	-	-	PAK4	ENST00000435673,p.A197V|ENST00000360442,p.A197V|NM_001014832,p.A197V|ENST00000358301,p.A197V|uc002okl.1,p.A197V|ENST00000593690,p.A197V|uc002okj.1,p.A197V|uc002okn.1,p.A197V|NM_001014831,p.A197V|NM_005884,p.A197V	retained_intron, protein_coding, processed_transcript	uc002okn.1	nonsynonymous SNV	exon3	c.C590T	p.A197V	VGTPQPAGLASGAKLAAGRPFNTYP	VGTPQPAGLASGVKLAAGRPFNTYP	9.0	8.0	-	-	4275_19:39663943-39663943 C>T_VGTPQPAGLASGVKLAAGRPFNTYP	0.0
15:85632647-85632647 G>T	0.0	4134	NSCLC	-	-	-	-	PDE8A	ENST00000339708,p.Q238H|NM_173454,p.Q238H|uc002bli.3,p.Q238H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002bli.3	nonsynonymous SNV	exon7	c.G714T	p.Q238H	DAIEITSEDRFIQEWQGIYYAKKKN	DAIEITSEDRFIHEWQGIYYAKKKN	6.0	6.0	-	-	4134_15:85632647-85632647 G>T_DAIEITSEDRFIHEWQGIYYAKKKN	0.0
15:65223062-65223062 A>G	1.0	3903	MELANOMA	-	-	-	-	ANKDD1A	ENST00000487867,p.M114V|ENST00000496660,p.M114V|ENST00000483400,p.M66V|uc002aoa.3,p.M205V|ENST00000395723,p.M114V|NM_182703,p.M205V|ENST00000395720,p.M205V|ENST00000380230,p.M205V|uc010bha.3,p.M114V|uc002any.3,p.M114V|ENST00000357698,p.M205V|uc002anz.3,p.M114V|uc002anx.1,p.M201V|uc002aob.3,p.M70V|ENST00000437723,p.M209V	 processed_transcript,retained_intron, nonsense_mediated_decay, protein_coding	uc010bha.3	nonsynonymous SNV	exon4	c.A340G	p.M114V	NTALHLAAGRGHMAVLQRLVDIGLD	NTALHLAAGRGHVAVLQRLVDIGLD	6.0	3.0	-	-	3903_15:65223062-65223062 A>G_NTALHLAAGRGHVAVLQRLVDIGLD	0.0
17:70120093-70120093 ->CC	1.0	4278	COLORECTAL	-	-	-	-	SOX9	ENST00000245479,p.A365fs|NM_000346,p.A365fs|uc002jiw.3,p.A365fs	protein_coding	uc002jiw.3	frameshift insertion	exon3	c.1095_1096insCC	p.A365fs	PPAPQAPPQPQAAPPQQPAAPPQQP	PPAPQAPPQPQAAPPHSSRRHPRSSHRRTR	10.0	4.0	-	-	4278_17:70120093-70120093 ->CC_PPAPQAPPQPQAAPPHSSRRHPRSSHRRTR	0.0
18:34320697-34320697 C>G	0.0	4326	BREAST	-	-	-	-	FHOD3	uc002kzt.1,p.L1027V|NM_001281740,p.L1219V|uc021uiv.1,p.L1219V|uc010dmz.1,p.L759V|uc010dnb.1,p.L23V|NM_025135,p.L1044V|NM_001281739,p.L1027V|ENST00000590592,p.L1219V|ENST00000445677,p.L1006V|ENST00000257209,p.L1044V|ENST00000591635,p.L240V|uc002kzs.1,p.L1044V|ENST00000359247,p.L1027V|ENST00000592128,p.L23V	retained_intron, protein_coding, processed_transcript	uc021uiv.1	nonsynonymous SNV	exon21	c.C3655G	p.L1219V	IQEAQLANPEIPLGSAEQFLLTLSS	IQEAQLANPEIPVGSAEQFLLTLSS	5.0	3.0	-	-	4326_18:34320697-34320697 C>G_IQEAQLANPEIPVGSAEQFLLTLSS	0.0
1:196695714-196695714 T>A	1.0	3879	MELANOMA	-	-	-	-	CFH	NM_000186,p.F663Y|uc001gtj.4,p.F663Y|ENST00000367429,p.F663Y	retained_intron, protein_coding, ambiguous_orf	uc001gtj.4	nonsynonymous SNV	exon13	c.T1988A	p.F663Y	HSEVVEYYCNPRFLMKGPNKIQCVD	HSEVVEYYCNPRYLMKGPNKIQCVD	6.0	1.0	-	-	3879_1:196695714-196695714 T>A_HSEVVEYYCNPRYLMKGPNKIQCVD	0.0
14:73137975-73137975 C>T	0.0	4346	COLORECTAL	-	-	-	-	DPF3	uc010ari.1,p.G315S|NM_012074,p.G315S|ENST00000381216,p.G315S|ENST00000366353,p.G370S|NM_001280543,p.G325S|ENST00000541685,p.G315S|uc010ttq.1,p.G325S|ENST00000546183,p.G325S|NM_001280544,p.G370S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ttq.1	nonsynonymous SNV	exon10	c.G973A	p.G325S	AAAAARTTEDLFGSTSESDTSTFHG	AAAAARTTEDLFSSTSESDTSTFHG	2.0	5.0	-	-	4346_14:73137975-73137975 C>T_AAAAARTTEDLFSSTSESDTSTFHG	0.0
11:12263852-12263852 G>A	1.0	3713	MELANOMA	-	-	-	-	MICAL2	NM_001282664,p.R810K|uc001mjz.3,p.R810K|NM_001282663,p.R810K|ENST00000342902,p.R810K|ENST00000256194,p.R810K|NM_014632,p.R810K|uc001mka.3,p.R810K|uc010rci.2,p.R810K	retained_intron, protein_coding, processed_transcript	uc010rci.2	nonsynonymous SNV	exon18	c.G2429A	p.R810K	AGSECLSRPWRARAKSDLQLGGTEN	AGSECLSRPWRAKAKSDLQLGGTEN	7.0	10.0	-	-	3713_11:12263852-12263852 G>A_AGSECLSRPWRAKAKSDLQLGGTEN	0.0
1:40236311-40236311 T>G	0.0	4046	OVARIAN	-	-	-	-	OXCT2	uc001ceb.1,p.D206A|ENST00000327582,p.D206A|NM_022120,p.D206A	protein_coding	uc001ceb.1	nonsynonymous SNV	exon1	c.A617C	p.D206A	GDHFLLERAIRADFALVKGWKADRA	GDHFLLERAIRAAFALVKGWKADRA	3.0	2.0	-	-	4046_1:40236311-40236311 T>G_GDHFLLERAIRAAFALVKGWKADRA	0.0
20:33440256-33440256 C>T	1.0	4046	OVARIAN	-	-	-	-	GGT7	uc002xay.3,p.G469R|NM_178026,p.G469R|ENST00000336431,p.G469R|uc002xaz.1,p.G486R	protein_coding, processed_transcript	uc002xaz.1	nonsynonymous SNV	exon12	c.G1456A	p.G486R	APAPLLPVYELDGAPTAAQVLIMGP	APAPLLPVYELDRAPTAAQVLIMGP	7.0	4.0	-	-	4046_20:33440256-33440256 C>T_APAPLLPVYELDRAPTAAQVLIMGP	0.0
3:130174393-130174393 G>A	0.0	3903	MELANOMA	-	-	-	-	COL6A5	uc021xdz.1,p.E264K|NM_001278298,p.E2225K|NM_153264,p.E2225K|ENST00000312481,p.E2225K|ENST00000512482,p.E60K|ENST00000432398,p.E2225K|ENST00000265379,p.E2225K|uc010htk.2,p.E2225K|uc010htj.2,p.E2225K|ENST00000373157,p.E168K	protein_coding, nonsense_mediated_decay	uc021xdz.1	nonsynonymous SNV	exon3	c.G790A	p.E264K	LNSGRESPFVKTEDNGSDYLVYLPS	LNSGRESPFVKTKDNGSDYLVYLPS	1.0	5.0	-	-	3903_3:130174393-130174393 G>A_LNSGRESPFVKTKDNGSDYLVYLPS	0.0
1:144880859-144880859 C>T	1.0	3919	MELANOMA	-	-	-	1	PDE4DIP	NM_001198834,p.G1257S|NM_001198832,p.G1213S|uc001elx.4,p.G1213S|uc021ouh.1,p.G1257S|NM_014644,p.G1257S|uc001elv.4,p.G264S|uc001elw.4,p.G1257S	-	uc021ouh.1	nonsynonymous SNV	exon26	c.G3769A	p.G1257S	ANELEKYRVMLTGESLVKQDSKQIQ	ANELEKYRVMLTSESLVKQDSKQIQ	1.0	4.0	-	-	3919_1:144880859-144880859 C>T_ANELEKYRVMLTSESLVKQDSKQIQ	0.0
3:178968705-178968705 G>A	1.0	3775	CERVICAL	-	-	-	-	KCNMB3	uc003fjn.3,p.S25L|ENST00000392685,p.S25L|NM_171830,p.S25L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fjn.3	nonsynonymous SNV	exon1	c.C74T	p.S25L	PSPFPQRTAFPASGKKRETDYSDGD	PSPFPQRTAFPALGKKRETDYSDGD	6.0	10.0	-	-	3775_3:178968705-178968705 G>A_PSPFPQRTAFPALGKKRETDYSDGD	0.0
1:157805671-157805671 T>G	0.0	4196	COLORECTAL	-	-	-	-	CD5L	ENST00000368174,p.E110D|NM_005894,p.E110D|uc001frk.4,p.E110D	protein_coding, processed_transcript	uc001frk.4	nonsynonymous SNV	exon3	c.A330C	p.E110D	GTEDTLAQCEQEEVYDCSHDEDAGA	GTEDTLAQCEQEDVYDCSHDEDAGA	4.0	3.0	-	-	4196_1:157805671-157805671 T>G_GTEDTLAQCEQEDVYDCSHDEDAGA	0.0
16:26147274-26147274 G>A	0.0	4129	NSCLC	-	-	-	-	HS3ST4	uc002dof.3,p.R359Q|NM_006040,p.R359Q|ENST00000331351,p.R359Q	protein_coding, processed_transcript	uc002dof.3	nonsynonymous SNV	exon2	c.G1076A	p.R359Q	FPLSQILFVSGERLIVDPAGEMAKV	FPLSQILFVSGEQLIVDPAGEMAKV	1.0	7.0	-	-	4129_16:26147274-26147274 G>A_FPLSQILFVSGEQLIVDPAGEMAKV	0.0
X:83128851-83128851 G>A	0.0	2591	MELANOMA	-	-	ID=COSM3364115,COSM3364116;OCCURENCE=1(kidney)	-	CYLC1	NM_021118,p.D379N|ENST00000329312,p.D379N|uc004eeh.2,p.D378N|uc004eei.2,p.D379N	protein_coding	uc004eei.2	nonsynonymous SNV	exon4	c.G1135A	p.D379N	PESTDTESGDAKDARNDSRNLKKAS	PESTDTESGDAKNARNDSRNLKKAS	1.0	10.0	-	-	2591_X:83128851-83128851 G>A_PESTDTESGDAKNARNDSRNLKKAS	0.0
1:43896743-43896743 C>T	1.0	3784	MELANOMA	0.0014	-	-	-	SZT2	ENST00000372442,p.S734L|ENST00000562955,p.S1576L|NM_015284,p.S1576L|uc001cjk.3,p.S1576L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001cjk.3	nonsynonymous SNV	exon32	c.C4727T	p.S1576L	LTLPLEVELPTASDPQHHRSTSESS	LTLPLEVELPTALDPQHHRSTSESS	7.0	5.0	-	-	3784_1:43896743-43896743 C>T_LTLPLEVELPTALDPQHHRSTSESS	0.0
20:44669244-44669244 C>T	0.0	3903	MELANOMA	-	-	-	-	SLC12A5	uc002xrb.2,p.P282L|uc010zxl.1,p.P305L|ENST00000243964,p.P282L|NM_001134771,p.P305L|NM_020708,p.P282L|ENST00000454036,p.P305L	protein_coding	uc010zxl.1	nonsynonymous SNV	exon7	c.C914T	p.P305L	IYAGVIKSAFDPPNFPICLLGNRTL	IYAGVIKSAFDPLNFPICLLGNRTL	1.0	5.0	-	-	3903_20:44669244-44669244 C>T_IYAGVIKSAFDPLNFPICLLGNRTL	0.0
17:58022867-58022867 G>A	0.0	4298	COLORECTAL	-	-	-	-	RPS6KB1	ENST00000406116,p.R443Q|uc010ddj.3,p.R443Q|NM_001272043,p.R443Q	retained_intron, nonsense_mediated_decay, processed_transcript, protein_coding	uc010ddj.3	nonsynonymous SNV	exon14	c.G1328A	p.R443Q	KIRSPRRFIGSPRTPVSTAMC	KIRSPRRFIGSPQTPVSTAMC	9.0	1.0	-	-	4298_17:58022867-58022867 G>A_KIRSPRRFIGSPQTPVSTAMC	0.0
5:13919340-13919340 G>A	1.0	4259	COLORECTAL	-	-	-	-	DNAH5	uc003jfd.2,p.P307L|NM_001369,p.P307L|ENST00000265104,p.P307L	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon7	c.C920T	p.P307L	SKFNYLLEQLKSPDVKAVLAVLAAA	SKFNYLLEQLKSLDVKAVLAVLAAA	4.0	3.0	-	-	4259_5:13919340-13919340 G>A_SKFNYLLEQLKSLDVKAVLAVLAAA	0.0
1:211093127-211093127 C>G	0.0	4346	COLORECTAL	-	-	-	-	KCNH1	uc001hib.2,p.K439N|uc001hic.2,p.K412N|ENST00000271751,p.K439N|NM_172362,p.K439N|NM_002238,p.K412N|ENST00000367007,p.K412N	protein_coding	uc001hic.2	nonsynonymous SNV	exon7	c.G1236C	p.K412N	GTPYQFNGSGSGKWEGGPSKNSVYI	GTPYQFNGSGSGNWEGGPSKNSVYI	2.0	8.0	-	-	4346_1:211093127-211093127 C>G_GTPYQFNGSGSGNWEGGPSKNSVYI	0.0
3:53694272-53694272 C>G	0.0	4046	OVARIAN	-	-	-	1	CACNA1D	NM_000720,p.R246G|NM_001128840,p.R246G|ENST00000288139,p.R246G|ENST00000422281,p.R246G|NM_001128839,p.R246G|uc003dgu.5,p.R246G|uc003dgy.5,p.R246G|ENST00000350061,p.R246G|uc003dgv.5,p.R246G	retained_intron, protein_coding, processed_transcript	uc003dgy.5	nonsynonymous SNV	exon5	c.C736G	p.R246G	FDVKALRAFRVLRPLRLVSGVPSLQ	FDVKALRAFRVLGPLRLVSGVPSLQ	5.0	9.0	-	-	4046_3:53694272-53694272 C>G_FDVKALRAFRVLGPLRLVSGVPSLQ	0.0
3:12872988-12872988 C>T	0.0	4281	COLORECTAL	-	-	ID=COSM3059879,COSM3059877,COSM3059878;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	CAND2	uc003bxk.2,p.R1134W|ENST00000295989,p.R1017W|uc003bxj.2,p.R1017W|ENST00000456430,p.R1134W|NM_001162499,p.R1134W|NM_012298,p.R1017W|ENST00000454887,p.R62W	protein_coding, processed_transcript, nonsense_mediated_decay	uc003bxk.2	nonsynonymous SNV	exon14	c.C3400T	p.R1134W	YDIRMLTFIMVARLATLCPAPVLQR	YDIRMLTFIMVAWLATLCPAPVLQR	2.0	10.0	-	-	4281_3:12872988-12872988 C>T_YDIRMLTFIMVAWLATLCPAPVLQR	0.0
8:144994112-144994112 C>T	1.0	2369	MELANOMA	-	-	-	-	PLEC	uc003zag.1,p.E3271K|ENST00000354589,p.E3293K|NM_201383,p.E3297K|ENST00000356346,p.E3279K|uc003zab.1,p.E3293K|uc003zac.1,p.E3297K|ENST00000354958,p.E3271K|NM_201384,p.E3293K|NM_201380,p.E3430K|uc003zad.2,p.E3293K|NM_201379,p.E3271K|ENST00000345136,p.E3293K|uc003zae.1,p.E3261K|uc003zaj.2,p.E3320K|uc003zah.2,p.E3279K|NM_201382,p.E3293K|uc003zaf.1,p.E3430K|NM_201381,p.E3261K|ENST00000436759,p.E3320K|ENST00000527096,p.E3316K|ENST00000398774,p.E3261K|ENST00000322810,p.E3430K|NM_201378,p.E3279K|NM_000445,p.E3320K|ENST00000357649,p.E3297K	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon33	c.G9958A	p.E3320K	VEKVIKILITIVEEVETLRQERLSF	VEKVIKILITIVKEVETLRQERLSF	8.0	6.0	-	-	2369_8:144994112-144994112 C>T_VEKVIKILITIVKEVETLRQERLSF	0.0
19:39380533-39380533 G>A	1.0	4000	MELANOMA	-	-	-	-	SIRT2	ENST00000392081,p.P76S|NM_012237,p.P113S|uc010egi.2,p.P76S|uc002ojv.2,p.P111S|ENST00000381766,p.P76S|ENST00000414941,p.P76S|uc002ojs.2,p.P93S|ENST00000249396,p.P113S|NM_030593,p.P76S|uc002ojt.2,p.P113S|ENST00000407552,p.P76S|NM_001193286,p.P76S|ENST00000420440,p.P76S|uc010egh.2,p.P76S|uc002oju.2,p.P76S|ENST00000358931,p.P113S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010egi.2	nonsynonymous SNV	exon4	c.C226T	p.P76S	TGLYDNLEKYHLPYPEAIFEISYFK	TGLYDNLEKYHLSYPEAIFEISYFK	8.0	8.0	-	-	4000_19:39380533-39380533 G>A_TGLYDNLEKYHLSYPEAIFEISYFK	0.0
2:43800098-43800098 C>A	1.0	4110	BILE DUCT	-	-	-	-	THADA	ENST00000402360,p.C588F|ENST00000403856,p.C588F|NM_022065,p.C588F|ENST00000405975,p.C588F|uc002rtd.3,p.C588F|NM_001083953,p.C588F|ENST00000415080,p.C298F|uc002rtc.4,p.C588F|ENST00000405006,p.C588F|ENST00000404790,p.C588F|uc002rsz.3,p.C298F|ENST00000402796,p.C171F|uc002rsx.4,p.C588F|ENST00000330266,p.C298F|uc002rta.2,p.C298F|uc002rtb.2,p.C588F|NM_001271643,p.C588F|NM_001271644,p.C588F|uc002rsw.4,p.C588F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rtd.3	nonsynonymous SNV	exon13	c.G1763T	p.C588F	TGQEQSFPSLGSCNSRGALGALMAC	TGQEQSFPSLGSFNSRGALGALMAC	8.0	8.0	-	-	4110_2:43800098-43800098 C>A_TGQEQSFPSLGSFNSRGALGALMAC	0.0
5:179296801-179296801 A>G	0.0	4317	COLORECTAL	-	-	-	-	TBC1D9B	uc011dgw.1,p.L96P|ENST00000519746,p.L96P|uc003mli.3,p.L920P|uc003mlj.3,p.L920P|uc003mlg.3,p.L96P|uc003mlh.3,p.L920P|ENST00000356834,p.L920P|uc011dgv.2,p.L96P|NM_015043,p.L920P|ENST00000444477,p.L78P|NM_198868,p.L920P|ENST00000355235,p.L920P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011dgw.1	nonsynonymous SNV	exon3	c.T287C	p.L96P	MSGMYHGDLTEKLKVLYKLHLPPAL	MSGMYHGDLTEKPKVLYKLHLPPAL	10.0	4.0	-	-	4317_5:179296801-179296801 A>G_MSGMYHGDLTEKPKVLYKLHLPPAL	0.0
18:43420206-43420206 G>A	0.0	4110	BILE DUCT	-	-	-	-	SIGLEC15	NM_213602,p.R302Q|ENST00000546268,p.R148Q|uc002lbl.1,p.R302Q|ENST00000389474,p.R302Q	retained_intron, protein_coding, processed_transcript	uc002lbl.1	nonsynonymous SNV	exon5	c.G905A	p.R302Q	RPEHLDTPDTPPRSQAQESNYENLS	RPEHLDTPDTPPQSQAQESNYENLS	3.0	10.0	-	-	4110_18:43420206-43420206 G>A_RPEHLDTPDTPPQSQAQESNYENLS	0.0
9:113170247-113170247 C>T	1.0	3713	MELANOMA	-	-	-	-	SVEP1	ENST00000374469,p.D2522N|uc010mtz.3,p.D2545N|NM_153366,p.D2545N|ENST00000297826,p.D471N|uc010mty.3,p.D471N|ENST00000401783,p.D2545N	protein_coding, processed_transcript	uc010mtz.3	nonsynonymous SNV	exon38	c.G7633A	p.D2545N	PSALTCLETGDWDVDAPSCNAIHCD	PSALTCLETGDWNVDAPSCNAIHCD	2.0	3.0	-	-	3713_9:113170247-113170247 C>T_PSALTCLETGDWNVDAPSCNAIHCD	0.0
16:88789055-88789055 T>A	1.0	4213	COLORECTAL	-	-	-	-	PIEZO1	uc010vpb.2,p.S1571C|NM_001142864,p.S1571C|ENST00000301015,p.S1571C	retained_intron, protein_coding, nonsense_mediated_decay	uc010vpb.2	nonsynonymous SNV	exon35	c.A4711T	p.S1571C	EVHRGVLDQLYTSQAEATLPGPTEA	EVHRGVLDQLYTCQAEATLPGPTEA	10.0	6.0	-	-	4213_16:88789055-88789055 T>A_EVHRGVLDQLYTCQAEATLPGPTEA	0.0
17:72862962-72862962 G>C	0.0	4317	COLORECTAL	-	-	-	-	FDXR	uc002jlz.3,p.P72A|ENST00000583917,p.P73A|ENST00000544854,p.P20A|uc010wrj.3,p.P70A|uc002jly.3,p.P72A|NM_024417,p.P72A|uc010wrl.2,p.P115A|uc010wrm.2,p.P73A|ENST00000413947,p.P103A|NM_001258013,p.P103A|uc002jlx.3,p.P72A|ENST00000581530,p.P72A|ENST00000579893,p.P21A|NM_001258014,p.P72A|ENST00000455107,p.P28A|NM_001258016,p.P20A|ENST00000293195,p.P72A|ENST00000581219,p.P115A|uc010wri.2,p.P20A|NM_001258015,p.P73A|NM_004110,p.P72A|ENST00000582944,p.P72A|NM_001258012,p.P115A|ENST00000420580,p.P73A|ENST00000442102,p.P115A|uc010wrk.2,p.P103A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wrm.2	nonsynonymous SNV	exon3	c.C217G	p.P73A	HPQAHVDIYEKQPVPFGLVRFGVAP	HPQAHVDIYEKQAVPFGLVRFGVAP	7.0	3.0	-	-	4317_17:72862962-72862962 G>C_HPQAHVDIYEKQAVPFGLVRFGVAP	0.0
20:2097686-2097686 G>C	0.0	4238	COLORECTAL	-	-	-	-	STK35	ENST00000381482,p.A423P|NM_080836,p.A423P|ENST00000493263,p.A284P|uc002wfw.4,p.A423P|ENST00000246032,p.A290P	protein_coding, nonsense_mediated_decay	uc002wfw.4	nonsynonymous SNV	exon3	c.G1267C	p.A423P	WLSSACGSDFYMAPEVWEGHYTAKA	WLSSACGSDFYMPPEVWEGHYTAKA	8.0	3.0	-	-	4238_20:2097686-2097686 G>C_WLSSACGSDFYMPPEVWEGHYTAKA	0.0
2:216916245-216916245 C>G	1.0	4160	COLORECTAL	-	-	-	-	PECR	uc002vft.3,p.G177A|NM_018441,p.G177A|ENST00000265322,p.G177A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002vft.3	nonsynonymous SNV	exon5	c.G530C	p.G177A	FPLAVHSGAARAGVYNLTKSLALEW	FPLAVHSGAARAAVYNLTKSLALEW	6.0	8.0	-	-	4160_2:216916245-216916245 C>G_FPLAVHSGAARAAVYNLTKSLALEW	0.0
16:9858337-9858337 G>A	0.0	4095	COLORECTAL	-	-	ID=COSM975079;OCCURENCE=1(endometrium)	1	GRIN2A	ENST00000330684,p.R1022C|uc002czo.4,p.R1022C|NM_001134408,p.R1022C|ENST00000396575,p.R1022C|NM_000833,p.R1022C|ENST00000535259,p.R865C|uc010uyn.2,p.R865C|ENST00000396573,p.R1022C|uc010uym.2,p.R1022C|ENST00000562109,p.R1022C|ENST00000404927,p.R1022C|uc002czr.4,p.R1022C|NM_001134407,p.R1022C	retained_intron, protein_coding, processed_transcript	uc010uyn.2	nonsynonymous SNV	exon12	c.C2593T	p.R865C	PRQLWKKSVDSIRQDSLSQNPVSQR	PRQLWKKSVDSICQDSLSQNPVSQR	4.0	9.0	-	-	4095_16:9858337-9858337 G>A_PRQLWKKSVDSICQDSLSQNPVSQR	0.0
8:42179953-42179953 G>T	1.0	2369	MELANOMA	-	-	-	1	IKBKB	NM_001190720,p.V641F|uc003xow.2,p.V643F|ENST00000520810,p.V643F|ENST00000379708,p.V420F|ENST00000416505,p.V584F|uc003xox.2,p.V364F|ENST00000520835,p.V641F|uc011lcq.2,p.V641F|uc011lcr.2,p.V584F|NM_001242778,p.V584F|NM_001556,p.V643F|uc010lxj.2,p.V420F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lcr.2	nonsynonymous SNV	exon18	c.G1750T	p.V584F	EVVSLMNEDEKTVVRLQEKRQKELW	EVVSLMNEDEKTFVRLQEKRQKELW	8.0	6.0	-	-	2369_8:42179953-42179953 G>T_EVVSLMNEDEKTFVRLQEKRQKELW	0.0
11:32874877-32874877 C>A	1.0	4326	BREAST	-	-	-	-	PRRG4	NM_024081,p.P162H|ENST00000257836,p.P162H|uc001mtx.3,p.P162H	protein_coding	uc001mtx.3	nonsynonymous SNV	exon6	c.C485A	p.P162H	CSSAVYERGRHTPSIIFRRPEEAAL	CSSAVYERGRHTHSIIFRRPEEAAL	5.0	6.0	-	-	4326_11:32874877-32874877 C>A_CSSAVYERGRHTHSIIFRRPEEAAL	0.0
8:48866460-48866460 ->GCA	0.0	4126	NSCLC	-	-	-	-	PRKDC	uc003xqj.3,p.E176delinsDA|uc003xqi.3,p.E176delinsDA|ENST00000314191,p.E176delinsDA|ENST00000338368,p.E176delinsDA	retained_intron, protein_coding, processed_transcript	uc003xqj.3	nonframeshift insertion	exon6	c.527_528insTGC	p.E176delinsDA	KKIPDTVLEKVYELLGLLGEVHPSE	KKIPDTVLEKVYDALLGLLGEVHPS	9.0	5.0	-	-	4126_8:48866460-48866460 ->GCA_KKIPDTVLEKVYDALLGLLGEVHPS	0.0
14:68191912-68191912 G>A	0.0	3903	MELANOMA	-	-	-	-	RDH12	ENST00000267502,p.R95Q|NM_152443,p.R95Q|ENST00000551171,p.R95Q|ENST00000539142,p.R95Q|uc001xjz.4,p.R95Q	retained_intron, protein_coding, processed_transcript	uc001xjz.4	nonsynonymous SNV	exon5	c.G284A	p.R95Q	IRVDTKNSQVLVRKLDLSDTKSIRA	IRVDTKNSQVLVQKLDLSDTKSIRA	3.0	4.0	-	-	3903_14:68191912-68191912 G>A_IRVDTKNSQVLVQKLDLSDTKSIRA	0.0
1:160327005-160327005 C>T	1.0	3713	MELANOMA	-	-	-	-	NCSTN	NM_001290184,p.R637C|ENST00000368065,p.R399C|uc010pjg.2,p.R399C|NM_001290186,p.R519C|uc010pjf.2,p.R519C|ENST00000368063,p.R637C|ENST00000294785,p.R657C|ENST00000535857,p.R519C|uc001fvy.3,p.R637C|uc001fvx.3,p.R657C|ENST00000392212,p.R637C|NM_015331,p.R657C	protein_coding, processed_transcript	uc010pjg.2	nonsynonymous SNV	exon11	c.C1195T	p.R399C	YSTWTESRWKDIRARIFLIASKELE	YSTWTESRWKDICARIFLIASKELE	10.0	3.0	-	-	3713_1:160327005-160327005 C>T_YSTWTESRWKDICARIFLIASKELE	0.0
15:32988799-32988799 G>A	1.0	3466	MELANOMA	-	-	-	-	SCG5	uc001zha.2,p.D210N|ENST00000497208,p.D192N|uc001zgz.2,p.D209N|ENST00000300175,p.D210N|NM_001144757,p.D210N|NM_003020,p.D209N|ENST00000494364,p.D191N|ENST00000413748,p.D209N	retained_intron, protein_coding, processed_transcript	uc001zha.2	nonsynonymous SNV	exon6	c.G628A	p.D210N	KKSVPHFSDEDKDPE	KKSVPHFSDEDKNPE	3.0	6.0	-	-	3466_15:32988799-32988799 G>A_KKSVPHFSDEDKNPE	0.0
7:130139748-130139748 C>T	1.0	3713	MELANOMA	-	-	-	-	MEST	uc011kph.2,p.L176F|ENST00000437945,p.L190F|ENST00000378576,p.L181F|NM_177525,p.L181F|ENST00000393187,p.L181F|uc003vqc.3,p.L181F|NM_001253900,p.L176F|ENST00000223215,p.L190F|uc003vqg.3,p.L190F|ENST00000427521,p.L181F|ENST00000421001,p.L181F|uc022alp.1,p.L181F|NM_001253902,p.L181F|NM_177524,p.L181F|NM_002402,p.L190F|ENST00000341441,p.L181F|NM_001253901,p.L181F|ENST00000416162,p.L181F|ENST00000463263,p.L48F|uc003vqd.3,p.L181F|uc003vqf.3,p.L181F	retained_intron, protein_coding, processed_transcript	uc022alp.1	nonsynonymous SNV	exon7	c.C541T	p.L181F	GGIFPETHRPLLLQKLLKDGGVLSP	GGIFPETHRPLLFQKLLKDGGVLSP	4.0	7.0	-	-	3713_7:130139748-130139748 C>T_GGIFPETHRPLLFQKLLKDGGVLSP	0.0
18:21485562-21485562 A>C	1.0	4335	COLORECTAL	-	-	-	-	LAMA3	ENST00000313654,p.K2231T|ENST00000587184,p.K566T|uc002kur.3,p.K2175T|NM_000227,p.K622T|NM_198129,p.K2231T|ENST00000399516,p.K2175T|NM_001127718,p.K566T|uc002kus.4,p.K622T|NM_001127717,p.K2175T|uc002kut.4,p.K566T|uc002kuq.3,p.K2231T|ENST00000269217,p.K622T	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc002kut.4	nonsynonymous SNV	exon14	c.A1697C	p.K566T	LSSNSDKLLNEAKMTQKKLKQEVSP	LSSNSDKLLNEATMTQKKLKQEVSP	9.0	4.0	-	-	4335_18:21485562-21485562 A>C_LSSNSDKLLNEATMTQKKLKQEVSP	0.0
2:69409764-69409764 C>T	1.0	3879	MELANOMA	-	-	-	-	ANTXR1	ENST00000303714,p.S442F|uc002sfg.3,p.S442F|NM_032208,p.S442F	retained_intron, protein_coding	uc002sfg.3	nonsynonymous SNV	exon16	c.C1325T	p.S442F	PRNLNNNMRRPSSPRKWYSPIKGKL	PRNLNNNMRRPSFPRKWYSPIKGKL	8.0	7.0	-	-	3879_2:69409764-69409764 C>T_PRNLNNNMRRPSFPRKWYSPIKGKL	0.0
21:14982694-14982694 C>A	0.0	4326	BREAST	-	-	-	-	POTED	NM_174981,p.H49N|uc002yjb.1,p.H49N|ENST00000299443,p.H49N	protein_coding	uc002yjb.1	nonsynonymous SNV	exon1	c.C145A	p.H49N	GSGKSNMGTSGDHDDSFMKMLRSKM	GSGKSNMGTSGDNDDSFMKMLRSKM	1.0	9.0	-	-	4326_21:14982694-14982694 C>A_GSGKSNMGTSGDNDDSFMKMLRSKM	0.0
2:201474083-201474083 G>A	0.0	3466	MELANOMA	-	-	ID=COSM3364485;OCCURENCE=1(kidney)	-	AOX1	ENST00000374700,p.D367N|NM_001159,p.D367N|uc002uvx.3,p.D367N	retained_intron, protein_coding, processed_transcript	uc002uvx.3	nonsynonymous SNV	exon12	c.G1099A	p.D367N	LGGHIISRHPDSDLNPILAVGNCTL	LGGHIISRHPDSNLNPILAVGNCTL	3.0	1.0	-	-	3466_2:201474083-201474083 G>A_LGGHIISRHPDSNLNPILAVGNCTL	0.0
8:23059346-23059346 C>T	1.0	4287	COLORECTAL	-	-	-	-	TNFRSF10A	NM_003844,p.E202K|ENST00000221132,p.E202K|uc003xda.3,p.E202K	retained_intron, protein_coding	uc003xda.3	nonsynonymous SNV	exon4	c.G604A	p.E202K	CKPGTFRNDNSAEMCRKCSRGCPRG	CKPGTFRNDNSAKMCRKCSRGCPRG	8.0	8.0	-	-	4287_8:23059346-23059346 C>T_CKPGTFRNDNSAKMCRKCSRGCPRG	0.0
7:146829397-146829397 A>G	0.0	4326	BREAST	-	-	-	2	CNTNAP2	uc003weu.2,p.S382G|ENST00000361727,p.S382G|NM_014141,p.S382G	protein_coding, processed_transcript	uc003weu.2	nonsynonymous SNV	exon8	c.A1144G	p.S382G	EPYTVPVFFNATSYLEVPGRLNQDL	EPYTVPVFFNATGYLEVPGRLNQDL	2.0	6.0	-	-	4326_7:146829397-146829397 A>G_EPYTVPVFFNATGYLEVPGRLNQDL	0.0
1:6556602-6556602 C>T	1.0	4326	BREAST	-	-	-	-	PLEKHG5	ENST00000537245,p.G34E|NM_001265592,p.G34E|uc031plb.1,p.G34E	retained_intron, protein_coding	uc031plb.1	nonsynonymous SNV	exon2	c.G101A	p.G34E	DAGHDQSPAEKKGLRCQNPACMDKG	DAGHDQSPAEKKELRCQNPACMDKG	6.0	8.0	-	-	4326_1:6556602-6556602 C>T_DAGHDQSPAEKKELRCQNPACMDKG	0.0
9:32633024-32633024 ->T	0.0	4346	COLORECTAL	-	-	-	-	TAF1L	uc003zrg.1,p.A852fs|ENST00000242310,p.A852fs|NM_153809,p.A852fs	protein_coding	uc003zrg.1	frameshift insertion	exon1	c.2553dupA	p.A852fs	RPRRIRMEDIKKAFPSHSESSIRKR	RPRRIRMEDIKKSLSFPFRKQHPEEAKALR	2.0	5.0	-	-	4346_9:32633024-32633024 ->T_RPRRIRMEDIKKSLSFPFRKQHPEEAKALR	0.0
17:37872096-37872096 C>T	1.0	3466	MELANOMA	-	-	-	1	ERBB2	ENST00000584450,p.H473Y|NM_001289938,p.H443Y|ENST00000578199,p.H443Y|NM_001005862,p.H443Y|uc002hsl.3,p.H443Y|uc002hso.3,p.H473Y|uc010cwb.3,p.H473Y|uc010cwa.3,p.H458Y|ENST00000540147,p.H443Y|ENST00000541774,p.H458Y|NM_004448,p.H473Y|ENST00000445658,p.H197Y|ENST00000584601,p.H443Y|ENST00000269571,p.H473Y|uc002hsp.3,p.H276Y|uc010wek.2,p.H197Y|ENST00000540042,p.H443Y|ENST00000406381,p.H443Y|NM_001289936,p.H458Y|NM_001289937,p.H473Y|uc002hsm.3,p.H443Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wek.2	nonsynonymous SNV	exon6	c.C589T	p.H197Y	LGSGLALIHHNTHLCFVHTVPWDQL	LGSGLALIHHNTYLCFVHTVPWDQL	6.0	9.0	CD8	-	3466_17:37872096-37872096 C>T_LGSGLALIHHNTYLCFVHTVPWDQL	1.0
1:173616111-173616111 C>T	0.0	3795	MELANOMA	-	-	-	-	ANKRD45	ENST00000333279,p.E124K|uc001gja.1,p.E124K|NM_198493,p.E124K	retained_intron, protein_coding	uc001gja.1	nonsynonymous SNV	exon3	c.G370A	p.E124K	TLLHCAAAWGRLETLKALVELDVDI	TLLHCAAAWGRLKTLKALVELDVDI	6.0	2.0	-	-	3795_1:173616111-173616111 C>T_TLLHCAAAWGRLKTLKALVELDVDI	0.0
9:97879609-97879611 GCA>-	1.0	4326	BREAST	-	-	-	1	FANCC	ENST00000289081,p.353_354del|uc004avi.4,p.353_354del|NM_000136,p.353_354del|NM_001243744,p.353_354del|uc022bkl.1,p.353_354del|NM_001243743,p.353_354del|ENST00000375305,p.353_354del|uc004avh.3,p.353_354del	protein_coding, processed_transcript	uc022bkl.1	nonframeshift deletion	exon11	c.1058_1060del	p.353_354del	FPYTSPSLAMVLLQDPQDIPRGHWLQ	FPYTSPSLAMVLQDPQDIPRGHWLQ	7.0	4.0	-	-	4326_9:97879609-97879611 GCA>-_FPYTSPSLAMVLQDPQDIPRGHWLQ	0.0
16:15829260-15829260 C>T	0.0	2556	MELANOMA	-	-	-	1	MYH11	uc010bvg.3,p.D989N|NM_022844,p.D1157N|NM_001040113,p.D1164N|uc002ddv.3,p.D1164N|uc002ddx.3,p.D1164N|ENST00000452625,p.D1164N|ENST00000338282,p.D1157N|uc002ddy.3,p.D1157N|uc002ddw.3,p.D1157N|NM_002474,p.D1157N|ENST00000396324,p.D1164N|ENST00000300036,p.D1157N|ENST00000576790,p.D1157N|NM_001040114,p.D1164N	retained_intron, protein_coding, processed_transcript	uc010bvg.3	nonsynonymous SNV	exon27	c.G2965A	p.D989N	GEELEALKTELEDTLDSTATQQELR	GEELEALKTELENTLDSTATQQELR	1.0	7.0	-	-	2556_16:15829260-15829260 C>T_GEELEALKTELENTLDSTATQQELR	0.0
22:45754630-45754630 C>T	0.0	4301	MELANOMA	-	-	-	-	SMC1B	ENST00000357450,p.E970K|NM_148674,p.E970K|NM_001291501,p.E970K|ENST00000404354,p.E970K|uc003bgd.3,p.E970K|uc003bgc.3,p.E970K	protein_coding	uc003bgd.3	nonsynonymous SNV	exon19	c.G2908A	p.E970K	EAESTQATIDIYEKEEAFEIDYSSL	EAESTQATIDIYKKEEAFEIDYSSL	4.0	2.0	-	-	4301_22:45754630-45754630 C>T_EAESTQATIDIYKKEEAFEIDYSSL	0.0
6:31616485-31616485 C>T	1.0	4189	MELANOMA	-	-	-	-	BAG6	ENST00000456286,p.R174K|ENST00000433828,p.R174K|ENST00000424480,p.R174K|ENST00000437771,p.R174K|uc011dnw.2,p.R174K|uc003nvh.4,p.R174K|ENST00000424176,p.R156K|ENST00000404765,p.R174K|uc003nvf.4,p.R174K|ENST00000435080,p.R174K|NM_080703,p.R174K|ENST00000441054,p.R156K|NM_001098534,p.R174K|ENST00000211379,p.R174K|ENST00000439687,p.R174K|uc003nvi.4,p.R174K|ENST00000451898,p.R156K|ENST00000434444,p.R156K|ENST00000456622,p.R156K|NM_080702,p.R174K|ENST00000362049,p.R174K|ENST00000375976,p.R174K|ENST00000452994,p.R174K|NM_001199698,p.R174K|ENST00000428326,p.R174K|NM_001199697,p.R174K|uc011dnx.2,p.R174K	retained_intron, protein_coding, processed_transcript	uc011dnx.2	nonsynonymous SNV	exon6	c.G521A	p.R174K	PRVRLVMAQHMIRDIQTLLSRMECR	PRVRLVMAQHMIKDIQTLLSRMECR	10.0	5.0	-	-	4189_6:31616485-31616485 C>T_PRVRLVMAQHMIKDIQTLLSRMECR	0.0
19:9085781-9085781 C>T	0.0	4246	COLORECTAL	-	-	-	2	MUC16	NM_024690,p.A2012T|ENST00000397910,p.A2012T|uc002mkp.3,p.A2012T	protein_coding, processed_transcript, nonsense_mediated_decay	uc002mkp.3	nonsynonymous SNV	exon1	c.G6034A	p.A2012T	QSTPYVNSVAVSASPTHENSVSSGS	QSTPYVNSVAVSTSPTHENSVSSGS	2.0	6.0	-	-	4246_19:9085781-9085781 C>T_QSTPYVNSVAVSTSPTHENSVSSGS	0.0
6:31657475-31657475 G>A	1.0	3784	MELANOMA	-	-	-	-	ABHD16A	uc011dny.2,p.P289S|uc003nvx.2,p.P103S|ENST00000375842,p.P103S|NM_021160,p.P322S|uc010jtc.2,p.P103S|ENST00000395952,p.P322S|ENST00000440843,p.P289S|uc011dnz.2,p.P103S|NM_001177515,p.P289S|uc003nvy.2,p.P322S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011dnz.2	nonsynonymous SNV	exon14	c.C307T	p.P103S	WNHPGFAGSTGVPFPQNEANAMDVV	WNHPGFAGSTGVSFPQNEANAMDVV	8.0	1.0	-	-	3784_6:31657475-31657475 G>A_WNHPGFAGSTGVSFPQNEANAMDVV	0.0
16:88804452-88804452 G>A	1.0	4078	GASTRIC	-	-	-	-	PIEZO1	uc010vpb.2,p.L304F|ENST00000301015,p.L304F|NM_001142864,p.L304F	retained_intron, protein_coding, nonsense_mediated_decay	uc010vpb.2	nonsynonymous SNV	exon8	c.C910T	p.L304F	GPTNCSSPHALVLNTGLDWPVYASP	GPTNCSSPHALVFNTGLDWPVYASP	9.0	10.0	-	-	4078_16:88804452-88804452 G>A_GPTNCSSPHALVFNTGLDWPVYASP	0.0
18:2673307-2673307 A>G	0.0	4335	COLORECTAL	-	-	-	-	SMCHD1	uc002klm.4,p.N151S|NM_015295,p.N151S|ENST00000261598,p.N151S|ENST00000320876,p.N151S	retained_intron, protein_coding, nonsense_mediated_decay	uc002klm.4	nonsynonymous SNV	exon4	c.A452G	p.N151S	NPLPFALAELIDNSLSATSRNIGVR	NPLPFALAELIDSSLSATSRNIGVR	8.0	7.0	-	-	4335_18:2673307-2673307 A>G_NPLPFALAELIDSSLSATSRNIGVR	0.0
10:115887350-115887350 G>C	1.0	4149	OVARIAN	-	-	-	-	CCDC186	ENST00000369287,p.Q755E|uc009xyd.1,p.Q353E|uc001lbc.1,p.Q755E|ENST00000543782,p.Q353E|uc001lbb.1,p.Q755E|NM_018017,p.Q755E	protein_coding, processed_transcript	uc009xyd.1	nonsynonymous SNV	exon9	c.C1057G	p.Q353E	NTGSSVAVDNFPQVDKAMLIERIVR	NTGSSVAVDNFPEVDKAMLIERIVR	9.0	9.0	-	-	4149_10:115887350-115887350 G>C_NTGSSVAVDNFPEVDKAMLIERIVR	0.0
11:66108281-66108287 GCCTCTG>-	1.0	4252	COLORECTAL	-	-	-	-	BRMS1	uc001ohp.1,p.Q165fs|NM_015399,p.Q165fs|ENST00000359957,p.Q165fs	retained_intron, protein_coding, nonsense_mediated_decay	uc001ohp.1	frameshift deletion	exon6	c.493_499del	p.Q165fs	YDTLQGELQERIQRLEEDRQSLDLS	YDTLQGELQERIWRRTARAWTSALNGGMTNCTPEAAPGLGTPCRPARGRRHLWFLAHTSCTCFKRSTSWRTGQPSKRLGQLCPLRRENRMDL	10.0	4.0	-	-	4252_11:66108281-66108287 GCCTCTG>-_YDTLQGELQERIWRRTARAWTSALNGGMTNCTPEAAPGLGTPCRPARGRRHLWFLAHTSCTCFKRSTSWRTGQPSKRLGQLCPLRRENRMDL	0.0
10:135032455-135032455 C>T	0.0	3903	MELANOMA	0.0005	-	ID=COSM325647;OCCURENCE=1(lung)	-	KNDC1	ENST00000368572,p.P1602S|uc001llz.1,p.P1600S|NM_152643,p.P1600S|ENST00000304613,p.P1600S	retained_intron, protein_coding, processed_transcript	uc001llz.1	nonsynonymous SNV	exon27	c.C4798T	p.P1600S	LSGLEHLAVRQSPAWRILPAKIAEV	LSGLEHLAVRQSSAWRILPAKIAEV	1.0	5.0	-	-	3903_10:135032455-135032455 C>T_LSGLEHLAVRQSSAWRILPAKIAEV	0.0
9:140509168-140509168 A>C	1.0	4037	NSCLC	-	-	-	-	ARRDC1	NM_152285,p.E318A|uc004cns.3,p.E318A|uc004cnp.2,p.E318A|uc004cnx.2,p.E193A|ENST00000371421,p.E318A	protein_coding, processed_transcript, nonsense_mediated_decay	uc004cnx.2	nonsynonymous SNV	exon3	c.A578C	p.E193A	LVVPSAPPQEEAEAEAAAGGPHFLD	LVVPSAPPQEEAAAEAAAGGPHFLD	10.0	9.0	-	-	4037_9:140509168-140509168 A>C_LVVPSAPPQEEAAAEAAAGGPHFLD	0.0
12:72316781-72316781 T>G	1.0	3466	MELANOMA	-	-	-	-	TBC1D15	uc001sww.3,p.C379G|NM_001146213,p.C608G|ENST00000485960,p.C608G|NM_001146214,p.C616G|uc001swv.3,p.C608G|ENST00000550746,p.C625G|uc001swu.3,p.C625G|ENST00000319106,p.C616G|uc010stt.2,p.C616G|ENST00000393309,p.C379G|NM_022771,p.C625G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010stt.2	nonsynonymous SNV	exon18	c.T1846G	p.C616G	QMVKCKELPQAVCEILGLQGSEVTT	QMVKCKELPQAVGEILGLQGSEVTT	9.0	9.0	-	-	3466_12:72316781-72316781 T>G_QMVKCKELPQAVGEILGLQGSEVTT	0.0
11:21592358-21592358 A>C	0.0	4246	COLORECTAL	-	-	-	-	NELL1	uc001mqh.3,p.S222R|ENST00000325319,p.S620R|NM_201551,p.S630R|uc001mqf.3,p.S630R|uc010rdo.2,p.S620R|uc001mqe.3,p.S677R|NM_001288714,p.S620R|ENST00000532434,p.S630R|NM_001288713,p.S705R|uc010rdp.2,p.S390R|ENST00000357134,p.S677R|NM_006157,p.S677R|uc009yid.3,p.S705R|ENST00000298925,p.S705R	retained_intron, protein_coding, processed_transcript	uc010rdp.2	nonsynonymous SNV	exon14	c.A1168C	p.S390R	FCRRTACDCQNPSADLFCCPECDTR	FCRRTACDCQNPRADLFCCPECDTR	1.0	4.0	-	-	4246_11:21592358-21592358 A>C_FCRRTACDCQNPRADLFCCPECDTR	0.0
4:4322514-4322514 A>C	0.0	4335	COLORECTAL	-	-	-	-	ZBTB49	uc010icz.3,p.D168A|ENST00000538529,p.D73A|uc003ghu.3,p.D590A|ENST00000355834,p.D468A|uc003ghv.3,p.D73A|ENST00000337872,p.D590A|NM_145291,p.D590A	protein_coding, nonsense_mediated_decay	uc010icz.3	nonsynonymous SNV	exon2	c.A503C	p.D168A	LRRHKKMHCKAGDESPDVLEELSQA	LRRHKKMHCKAGAESPDVLEELSQA	5.0	2.0	-	-	4335_4:4322514-4322514 A>C_LRRHKKMHCKAGAESPDVLEELSQA	0.0
17:57290220-57290220 T>G	1.0	4298	COLORECTAL	-	-	-	-	SMG8	ENST00000582469,p.L222R|ENST00000300917,p.L679R|NM_018149,p.L679R|ENST00000543872,p.L679R|uc002ixi.3,p.L679R	protein_coding, processed_transcript, nonsense_mediated_decay	uc002ixi.3	nonsynonymous SNV	exon3	c.T2036G	p.L679R	SSPAPPDSDADKLKEKEPQTQGEST	SSPAPPDSDADKRKEKEPQTQGEST	5.0	8.0	-	-	4298_17:57290220-57290220 T>G_SSPAPPDSDADKRKEKEPQTQGEST	0.0
19:57286508-57286508 G>T	0.0	4129	NSCLC	-	-	-	-	ZIM2	uc010ygr.1,p.H174N|uc002qnq.2,p.H378N|uc010ygq.1,p.H174N|NM_001146326,p.H378N|ENST00000599935,p.H378N|ENST00000391708,p.H378N|uc010ygs.1,p.H378N|NM_001146327,p.H378N|uc002qnr.2,p.H378N|NM_015363,p.H378N|ENST00000221722,p.H378N|uc010etp.2,p.H378N|ENST00000601070,p.H378N|ENST00000593711,p.H378N	retained_intron, protein_coding, nonsense_mediated_decay	uc010ygs.1	nonsynonymous SNV	exon11	c.C1132A	p.H378N	YLMPHLNRHQKTHSGRKTSGCNEGR	YLMPHLNRHQKTNSGRKTSGCNEGR	1.0	8.0	-	-	4129_19:57286508-57286508 G>T_YLMPHLNRHQKTNSGRKTSGCNEGR	0.0
8:145000009-145000009 G>A	1.0	3795	MELANOMA	-	-	-	-	PLEC	NM_201380,p.A1500V|ENST00000398774,p.A1331V|ENST00000322810,p.A1500V|ENST00000527096,p.A1386V|ENST00000436759,p.A1390V|NM_201382,p.A1363V|NM_201378,p.A1349V|uc003zag.1,p.A1341V|uc003zac.1,p.A1367V|ENST00000354958,p.A1341V|NM_201383,p.A1367V|uc003zab.1,p.A1363V|NM_201381,p.A1331V|uc003zae.1,p.A1331V|ENST00000345136,p.A1363V|uc003zaf.1,p.A1500V|NM_000445,p.A1390V|ENST00000354589,p.A1363V|ENST00000357649,p.A1367V|NM_201379,p.A1341V|uc003zad.2,p.A1363V|uc003zah.2,p.A1349V|NM_201384,p.A1363V|uc003zaj.2,p.A1390V|ENST00000356346,p.A1349V	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon32	c.C4169T	p.A1390V	AEQQRAEERERLAEVEAALEKQRQL	AEQQRAEERERLVEVEAALEKQRQL	9.0	3.0	-	-	3795_8:145000009-145000009 G>A_AEQQRAEERERLVEVEAALEKQRQL	0.0
4:5664857-5664859 CCC>-	0.0	4158	COLORECTAL	-	-	-	-	EVC2	uc003gij.3,p.374_374del|ENST00000310917,p.294_294del|uc003gik.3,p.294_294del|ENST00000344938,p.374_374del|ENST00000509670,p.294_294del|NM_147127,p.374_374del|NM_001166136,p.294_294del|ENST00000344408,p.374_374del|ENST00000475313,p.294_294del	protein_coding, nonsense_mediated_decay	uc003gik.3	nonframeshift deletion	exon9	c.880_882del	p.294_294del	DQMIDILSSEDPGSMLQALEELEIA	DQMIDILSSEDPSMLQALEELEIAT	4.0	6.0	-	-	4158_4:5664857-5664859 CCC>-_DQMIDILSSEDPSMLQALEELEIAT	0.0
19:36398149-36398149 G>A	0.0	4213	COLORECTAL	-	-	-	-	TYROBP	ENST00000585901,p.R114C	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000585901	nonsynonymous SNV	exon4	c.C340T	p.R114C	QHPSPPAATRKQRITETESPYQELQ	QHPSPPAATRKQCITETESPYQELQ	10.0	8.0	-	-	4213_19:36398149-36398149 G>A_QHPSPPAATRKQCITETESPYQELQ	0.0
12:64041124-64041124 A>G	0.0	4278	COLORECTAL	-	-	-	-	DPY19L2	uc001srp.1,p.C204R|ENST00000324472,p.C204R|NM_173812,p.C204R	retained_intron, protein_coding, nonsense_mediated_decay	uc001srp.1	nonsynonymous SNV	exon5	c.T610C	p.C204R	HLYPEVIIASWYCTFMGIMNLFGLE	HLYPEVIIASWYRTFMGIMNLFGLE	6.0	1.0	-	-	4278_12:64041124-64041124 A>G_HLYPEVIIASWYRTFMGIMNLFGLE	0.0
20:37005269-37005269 C>A	0.0	4259	COLORECTAL	-	-	-	-	LBP	ENST00000217407,p.D468E|NM_004139,p.D468E|uc002xic.2,p.D468E	protein_coding	uc002xic.2	nonsynonymous SNV	exon15	c.C1404A	p.D468E	VQLYDLGLQIHKDFLFLGANVQYMR	VQLYDLGLQIHKEFLFLGANVQYMR	4.0	3.0	-	-	4259_20:37005269-37005269 C>A_VQLYDLGLQIHKEFLFLGANVQYMR	0.0
19:18994902-18994902 G>A	0.0	4155	MELANOMA	-	-	-	-	CERS1	uc010ebx.3,p.A97V|uc002nkj.3,p.A195V|NM_001290265,p.A97V|ENST00000542296,p.A97V|uc002nki.1,p.A195V|ENST00000427170,p.A195V|NM_198207,p.A195V|NM_021267,p.A195V|ENST00000429504,p.A195V	protein_coding	uc010ebx.3	nonsynonymous SNV	exon3	c.C290T	p.A97V	HVVTLILIVSSYAFRYHNVGILVLF	HVVTLILIVSSYVFRYHNVGILVLF	7.0	3.0	-	-	4155_19:18994902-18994902 G>A_HVVTLILIVSSYVFRYHNVGILVLF	0.0
1:117122181-117122181 T>C	1.0	4284	COLORECTAL	-	-	-	-	IGSF3	ENST00000369486,p.Q1056R|NM_001542,p.Q1076R|uc031pnr.1,p.Q1076R|ENST00000318837,p.Q1076R|NM_001007237,p.Q1056R|uc001egr.2,p.Q1056R|ENST00000369483,p.Q1076R	protein_coding, processed_transcript	uc031pnr.1	nonsynonymous SNV	exon10	c.A3227G	p.Q1076R	PEGSPWEGRLRFQRLSPVLYRLTVL	PEGSPWEGRLRFRRLSPVLYRLTVL	7.0	4.0	-	-	4284_1:117122181-117122181 T>C_PEGSPWEGRLRFRRLSPVLYRLTVL	0.0
X:103432841-103432841 A>G	1.0	4335	COLORECTAL	-	-	-	-	FAM199X	uc004elx.3,p.S101G	protein_coding, processed_transcript	uc004elx.3	nonsynonymous SNV	exon3	c.A301G	p.S101G	TSGVSGASASASSSSASMKRSKQRK	TSGVSGASASASGSSASMKRSKQRK	6.0	1.0	-	-	4335_X:103432841-103432841 A>G_TSGVSGASASASGSSASMKRSKQRK	0.0
2:238664814-238664814 G>T	1.0	4284	COLORECTAL	-	-	-	-	LRRFIP1	NM_001137550,p.R372I|ENST00000308482,p.R372I|uc002vxc.3,p.R372I	retained_intron, protein_coding, processed_transcript	uc002vxc.3	nonsynonymous SNV	exon16	c.G1115T	p.R372I	FQFAEVKEALKQREEMLEEIRQLQQ	FQFAEVKEALKQIEEMLEEIRQLQQ	10.0	10.0	-	-	4284_2:238664814-238664814 G>T_FQFAEVKEALKQIEEMLEEIRQLQQ	0.0
1:67288187-67288187 T>G	1.0	4244	COLORECTAL	-	-	-	-	WDR78	ENST00000371026,p.I785L|uc009waw.3,p.I498L|uc001dcx.3,p.I785L|ENST00000431318,p.I498L|NM_024763,p.I785L|ENST00000464352,p.I518L	protein_coding, processed_transcript, nonsense_mediated_decay	uc009waw.3	nonsynonymous SNV	exon11	c.A1492C	p.I498L	IWDLHISTLDPLIVNTANPGIKFTT	IWDLHISTLDPLLVNTANPGIKFTT	6.0	10.0	-	-	4244_1:67288187-67288187 T>G_IWDLHISTLDPLLVNTANPGIKFTT	0.0
X:53438753-53438753 C>A	0.0	4298	COLORECTAL	-	-	-	2	SMC1A	uc004dsg.3,p.Q404H|NM_001281463,p.Q382H|ENST00000375340,p.Q170H|NM_006306,p.Q404H|ENST00000322213,p.Q404H|uc011mof.2,p.Q170H|uc011moe.2,p.Q382H	protein_coding, processed_transcript	uc011mof.2	nonsynonymous SNV	exon4	c.G510T	p.Q170H	ELEKFNRDQKADQDRLDLEERKKVE	ELEKFNRDQKADHDRLDLEERKKVE	10.0	2.0	-	-	4298_X:53438753-53438753 C>A_ELEKFNRDQKADHDRLDLEERKKVE	0.0
3:126736592-126736592 G>A	1.0	4237	NSCLC	-	-	-	-	PLXNA1	ENST00000251772,p.G1150S|ENST00000393409,p.G1173S|NM_032242,p.G1173S|uc003ejg.3,p.G1173S	retained_intron, protein_coding, processed_transcript	uc003ejg.3	nonsynonymous SNV	exon18	c.G3517A	p.G1173S	LELKPSSPLILKGRNLLPPAPGNSR	LELKPSSPLILKSRNLLPPAPGNSR	9.0	10.0	-	-	4237_3:126736592-126736592 G>A_LELKPSSPLILKSRNLLPPAPGNSR	0.0
3:126181024-126181024 G>A	1.0	3903	MELANOMA	-	-	-	-	ZXDC	uc003eiv.3,p.P494L|ENST00000336332,p.P494L|uc003eix.2,p.P494L|ENST00000389709,p.P494L|NM_001040653,p.P494L|NM_025112,p.P494L	retained_intron, protein_coding, nonsense_mediated_decay	uc003eix.2	nonsynonymous SNV	exon6	c.C1481T	p.P494L	LLPQLEAPSSLTPSSELSSPGQSEL	LLPQLEAPSSLTLSSELSSPGQSEL	7.0	3.0	-	-	3903_3:126181024-126181024 G>A_LLPQLEAPSSLTLSSELSSPGQSEL	0.0
17:73945826-73945826 G>A	1.0	3678	MELANOMA	-	-	-	-	ACOX1	NM_007292,p.T484I|ENST00000537812,p.T446I|ENST00000301608,p.T484I|uc002jqf.3,p.T484I|ENST00000293217,p.T484I|uc002jqe.3,p.T484I|uc010wsr.2,p.T416I|uc010wsq.2,p.T446I|NM_001185039,p.T446I|NM_004035,p.T484I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wsr.2	nonsynonymous SNV	exon11	c.C1247T	p.T416I	PTMVDINSPESLTEAYKLRAARLVE	PTMVDINSPESLIEAYKLRAARLVE	8.0	8.0	-	-	3678_17:73945826-73945826 G>A_PTMVDINSPESLIEAYKLRAARLVE	0.0
8:14181694-14181694 C>T	0.0	4186	BREAST	-	-	-	-	SGCZ	uc003wwq.3,p.R85K|ENST00000382080,p.R85K|NM_139167,p.R85K	protein_coding	uc003wwq.3	nonsynonymous SNV	exon3	c.G254A	p.R85K	VMNFTVDGMGNLRVTKKGIRLEGIS	VMNFTVDGMGNLKVTKKGIRLEGIS	1.0	9.0	-	-	4186_8:14181694-14181694 C>T_VMNFTVDGMGNLKVTKKGIRLEGIS	0.0
6:10803953-10803953 T>G	0.0	4078	GASTRIC	-	-	-	-	MAK	uc003mzm.3,p.K221N|ENST00000474039,p.K221N|ENST00000538030,p.K221N|uc021yll.1,p.K221N|ENST00000313243,p.K221N|NM_005906,p.K221N|ENST00000354489,p.K221N|uc021ylk.1,p.K221N|ENST00000536370,p.K221N|NM_001242957,p.K221N|NM_001242385,p.K221N	protein_coding, processed_transcript	uc021yll.1	nonsynonymous SNV	exon7	c.A663C	p.K221N	IFKICQVLGTPKKSDWPEGYQLASS	IFKICQVLGTPKNSDWPEGYQLASS	1.0	8.0	-	-	4078_6:10803953-10803953 T>G_IFKICQVLGTPKNSDWPEGYQLASS	0.0
3:48621376-48621376 C>T	1.0	3784	MELANOMA	-	-	ID=COSM419967;OCCURENCE=1(urinary_tract)	-	COL7A1	ENST00000328333,p.G1412E|NM_000094,p.G1412E|ENST00000454817,p.G1412E|uc003ctz.2,p.G1412E	retained_intron, protein_coding, processed_transcript	uc003ctz.2	nonsynonymous SNV	exon38	c.G4235A	p.G1412E	GDKGDRGERGPPGPGEGGIAPGEPG	GDKGDRGERGPPEPGEGGIAPGEPG	5.0	7.0	-	-	3784_3:48621376-48621376 C>T_GDKGDRGERGPPEPGEGGIAPGEPG	0.0
17:73227673-73227673 G>A	1.0	4252	COLORECTAL	-	-	-	-	NUP85	ENST00000579557,p.G168D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000579557	nonsynonymous SNV	exon5	c.G503A	p.G168D	FDIHQVIKECSFGSNMREFLLLEYA	FDIHQVIKECSFDSNMREFLLLEYA	10.0	10.0	-	-	4252_17:73227673-73227673 G>A_FDIHQVIKECSFDSNMREFLLLEYA	0.0
5:50111353-50111353 G>A	1.0	4275	COLORECTAL	-	-	-	-	PARP8	uc003jop.3,p.A555T|ENST00000503750,p.A555T|ENST00000514342,p.A308T|NM_001178056,p.A555T|ENST00000514067,p.A555T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jop.3	nonsynonymous SNV	exon15	c.G1663A	p.A555T	VMNEAADEIATGAQKKNYDRVMKAL	VMNEAADEIATGTQKKNYDRVMKAL	9.0	5.0	-	-	4275_5:50111353-50111353 G>A_VMNEAADEIATGTQKKNYDRVMKAL	0.0
19:17306069-17306069 C>T	1.0	3713	MELANOMA	-	-	-	-	MYO9B	ENST00000595641,p.P1278L|NM_004145,p.P1278L|uc002nfi.3,p.P1278L|uc010eak.3,p.P1278L|uc002nfj.1,p.P1278L|NM_001130065,p.P1278L|ENST00000594824,p.P1278L|ENST00000595618,p.P1278L|ENST00000397274,p.P1278L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010eak.3	nonsynonymous SNV	exon22	c.C3833T	p.P1278L	GSAPETPEDKSKPCGSPRVQEKPDS	GSAPETPEDKSKLCGSPRVQEKPDS	10.0	9.0	-	-	3713_19:17306069-17306069 C>T_GSAPETPEDKSKLCGSPRVQEKPDS	0.0
2:26410996-26410996 C>T	1.0	2556	MELANOMA	-	-	-	-	GAREML	NM_001168241,p.A832V|uc002rgx.2,p.A622V|NM_001191033,p.A622V|ENST00000407684,p.A622V|uc002rgw.2,p.A832V|ENST00000401533,p.A832V	protein_coding, processed_transcript	uc002rgx.2	nonsynonymous SNV	exon6	c.C1865T	p.A622V	FIGLSEDVVSFFARERIDGSIFVQL	FIGLSEDVVSFFVRERIDGSIFVQL	5.0	9.0	-	-	2556_2:26410996-26410996 C>T_FIGLSEDVVSFFVRERIDGSIFVQL	0.0
22:21350356-21350356 G>A	0.0	4149	OVARIAN	-	-	-	1	LZTR1	ENST00000215739,p.R725H|ENST00000389355,p.R706H|uc011ahy.2,p.R706H|uc002ztn.3,p.R684H|NM_006767,p.R725H|uc002zto.3,p.R725H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ahy.2	nonsynonymous SNV	exon17	c.G2117A	p.R706H	MVPSRQAFESMLRYIYYGEVNMPPE	MVPSRQAFESMLHYIYYGEVNMPPE	5.0	6.0	-	-	4149_22:21350356-21350356 G>A_MVPSRQAFESMLHYIYYGEVNMPPE	0.0
2:39553065-39553065 G>A	1.0	3466	MELANOMA	-	-	-	-	MAP4K3	NM_003618,p.P234S|ENST00000263881,p.P234S|ENST00000437545,p.P171S|ENST00000341681,p.P234S|NM_001270425,p.P234S|uc002rro.4,p.P234S|uc002rrp.4,p.P234S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rrp.4	nonsynonymous SNV	exon10	c.C700T	p.P234S	ALFLMTKSNFQPPKLKDKMKWSNSF	ALFLMTKSNFQPSKLKDKMKWSNSF	7.0	3.0	-	-	3466_2:39553065-39553065 G>A_ALFLMTKSNFQPSKLKDKMKWSNSF	0.0
11:65373246-65373246 G>A	1.0	3713	MELANOMA	-	-	-	-	MAP3K11	uc010rol.2,p.P349L|uc001oew.3,p.P606L|ENST00000530153,p.P349L|uc001oex.1,p.P113L|uc001oev.3,p.P22L|ENST00000309100,p.P606L|ENST00000532507,p.P22L|NM_002419,p.P606L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rol.2	nonsynonymous SNV	exon8	c.C1046T	p.P349L	SDDSSPLGSPSTPPALNGNPPRPSL	SDDSSPLGSPSTLPALNGNPPRPSL	9.0	3.0	-	-	3713_11:65373246-65373246 G>A_SDDSSPLGSPSTLPALNGNPPRPSL	0.0
7:73530244-73530244 C>T	1.0	3466	MELANOMA	-	-	-	-	LIMK1	NM_002314,p.T508I|ENST00000418310,p.T538I|NM_001204426,p.T474I|uc003uab.3,p.T474I|ENST00000538333,p.T474I|uc003uaa.2,p.T508I|ENST00000336180,p.T508I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uab.3	nonsynonymous SNV	exon12	c.C1421T	p.T474I	RSLKKPDRKKRYTVVGNPYWMAPEM	RSLKKPDRKKRYIVVGNPYWMAPEM	9.0	8.0	-	-	3466_7:73530244-73530244 C>T_RSLKKPDRKKRYIVVGNPYWMAPEM	0.0
7:128317802-128317802 G>A	1.0	3678	MELANOMA	-	-	-	-	FAM71F2	ENST00000480462,p.D184N|NM_001012454,p.D184N|uc003vnk.4,p.D184N|NM_001128926,p.D175N|uc010llm.1,p.D175N|ENST00000434001,p.D175N|NM_001290255,p.D89N|ENST00000474069,p.D175N|ENST00000378704,p.D175N|NM_001290254,p.D89N	protein_coding, processed_transcript	uc010llm.1	nonsynonymous SNV	exon3	c.G523A	p.D175N	KILQKGLSITTKDPRIKFTHCLVPK	KILQKGLSITTKNPRIKFTHCLVPK	5.0	1.0	-	-	3678_7:128317802-128317802 G>A_KILQKGLSITTKNPRIKFTHCLVPK	0.0
21:34927316-34927316 C>T	1.0	3784	MELANOMA	-	-	-	-	SON	ENST00000290239,p.R1927C|NM_001291411,p.R1927C|uc002ysd.3,p.R918C|ENST00000455528,p.R1927C|ENST00000300278,p.R1927C|uc002ysg.3,p.R918C|NM_032195,p.R1927C|ENST00000381679,p.R1927C|uc002ysc.3,p.R1927C|ENST00000356577,p.R1927C|uc002yse.1,p.R1927C|uc002ysb.1,p.R1927C|NM_138927,p.R1927C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ysg.3	nonsynonymous SNV	exon1	c.C2752T	p.R918C	RKTVRARSRTPSRRSRSHTPSRRRR	RKTVRARSRTPSCRSRSHTPSRRRR	10.0	3.0	CD8	-	3784_21:34927316-34927316 C>T_RKTVRARSRTPSCRSRSHTPSRRRR	1.0
17:39597112-39597112 C>T	0.0	3903	MELANOMA	-	-	-	-	KRT38	ENST00000246646,p.R21K|NM_006771,p.R21K|uc002hwq.1,p.R21K	protein_coding	uc002hwq.1	nonsynonymous SNV	exon1	c.G62A	p.R21K	SCPLGCTMAPGARNVSVSPIDIGCQ	SCPLGCTMAPGAKNVSVSPIDIGCQ	1.0	5.0	-	-	3903_17:39597112-39597112 C>T_SCPLGCTMAPGAKNVSVSPIDIGCQ	0.0
11:763414-763414 T>C	1.0	4180	BREAST	-	-	-	-	TALDO1	ENST00000528097,p.C178R|NM_006755,p.C178R|uc001lra.3,p.C178R|ENST00000319006,p.C178R|uc001lqz.3,p.C178R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001lra.3	nonsynonymous SNV	exon5	c.T532C	p.C178R	MTLLFSFAQAVACAEAGVTLISPFV	MTLLFSFAQAVARAEAGVTLISPFV	10.0	10.0	-	-	4180_11:763414-763414 T>C_MTLLFSFAQAVARAEAGVTLISPFV	0.0
16:55517005-55517005 T>C	1.0	3466	MELANOMA	-	-	-	-	MMP2	ENST00000570308,p.F37S|ENST00000543485,p.F37S|ENST00000437642,p.F63S|ENST00000568715,p.F37S|ENST00000219070,p.F113S|uc010ccc.3,p.F63S|ENST00000564864,p.F37S|NM_001127891,p.F63S|NM_004530,p.F113S|uc002ehz.4,p.F113S|uc010vhd.2,p.F37S	protein_coding, nonsense_mediated_decay	uc010vhd.2	nonsynonymous SNV	exon2	c.T110C	p.F37S	RCGNPDVANYNFFPRKPKWDKNQIT	RCGNPDVANYNFSPRKPKWDKNQIT	10.0	3.0	-	-	3466_16:55517005-55517005 T>C_RCGNPDVANYNFSPRKPKWDKNQIT	0.0
19:5231497-5231497 G>A	0.0	4081	COLORECTAL	-	-	-	-	PTPRS	ENST00000587303,p.P660L|ENST00000262963,p.P656L|ENST00000348075,p.P647L|NM_130854,p.P647L|ENST00000372412,p.P661L|uc002mbv.3,p.P660L|ENST00000357368,p.P660L|uc002mbw.3,p.P647L|ENST00000588012,p.P647L|NM_002850,p.P660L	retained_intron, protein_coding, processed_transcript	uc002mbw.3	nonsynonymous SNV	exon11	c.C1940T	p.P647L	NGALVGYSVRYRPLGSEDPEPKEVN	NGALVGYSVRYRLLGSEDPEPKEVN	8.0	4.0	-	-	4081_19:5231497-5231497 G>A_NGALVGYSVRYRLLGSEDPEPKEVN	0.0
15:56208863-56208863 G>C	0.0	4213	COLORECTAL	-	-	-	-	NEDD4	uc002adi.3,p.T56S|ENST00000508342,p.T56S|NM_001284338,p.T56S|uc010bfm.3,p.T56S|uc002adj.3,p.T56S|NM_001284339,p.T56S|ENST00000338963,p.T56S|NM_198400,p.T56S|ENST00000506154,p.T56S|uc010ugj.2,p.T56S|NM_001284340,p.T56S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ugj.2	nonsynonymous SNV	exon1	c.C167G	p.T56S	SNVVQMKLTPRQTALAPLIKENVQS	SNVVQMKLTPRQSALAPLIKENVQS	7.0	5.0	-	-	4213_15:56208863-56208863 G>C_SNVVQMKLTPRQSALAPLIKENVQS	0.0
2:113676140-113676140 G>T	0.0	2591	MELANOMA	-	-	-	-	IL37	uc002tik.3,p.K116N|uc002tij.3,p.K137N|NM_173204,p.K97N|uc002til.3,p.K97N|NM_173203,p.K76N|ENST00000263326,p.K137N|uc002tin.3,p.K111N|NM_173205,p.K111N|ENST00000349806,p.K76N|ENST00000353225,p.K97N|NM_173202,p.K116N|ENST00000352179,p.K116N|NM_014439,p.K137N|uc002tim.3,p.K76N|ENST00000311328,p.K111N	protein_coding	uc002tin.3	nonsynonymous SNV	exon4	c.G333T	p.K111N	DKGQSHPSLQLKKEKLMKLAAQKES	DKGQSHPSLQLKNEKLMKLAAQKES	1.0	8.0	-	-	2591_2:113676140-113676140 G>T_DKGQSHPSLQLKNEKLMKLAAQKES	0.0
7:39990346-39990346 C>G	1.0	4326	BREAST	-	-	-	-	CDK13	uc003thh.4,p.Q36E|ENST00000340829,p.Q36E|NM_003718,p.Q36E|ENST00000181839,p.Q36E|NM_031267,p.Q36E|uc003thi.4,p.Q36E	retained_intron, protein_coding, processed_transcript	uc003thi.4	nonsynonymous SNV	exon1	c.C106G	p.Q36E	ERRKRRRFLSPQQPPLLLPLLQPQL	ERRKRRRFLSPQEPPLLLPLLQPQL	9.0	2.0	-	-	4326_7:39990346-39990346 C>G_ERRKRRRFLSPQEPPLLLPLLQPQL	0.0
19:23542703-23542703 T>A	1.0	4335	COLORECTAL	-	-	-	-	ZNF91	uc010xrj.2,p.E994D|ENST00000397082,p.E994D|NM_001300951,p.E994D|NM_003430,p.E1026D|ENST00000300619,p.E1026D|uc002nre.3,p.E1026D	retained_intron, protein_coding, processed_transcript	uc010xrj.2	nonsynonymous SNV	exon3	c.A2982T	p.E994D	RMHTGEKPYKCEECGKAFNRSSKLT	RMHTGEKPYKCEDCGKAFNRSSKLT	10.0	2.0	-	-	4335_19:23542703-23542703 T>A_RMHTGEKPYKCEDCGKAFNRSSKLT	0.0
12:49436929-49436929 A>C	1.0	3713	MELANOMA	-	-	-	1	KMT2D	ENST00000301067,p.S1858R|uc001rta.4,p.S1858R|NM_003482,p.S1858R	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon25	c.T5574G	p.S1858R	PEDGGVKASPVPSDPEKPGTPGEGM	PEDGGVKASPVPRDPEKPGTPGEGM	9.0	8.0	-	-	3713_12:49436929-49436929 A>C_PEDGGVKASPVPRDPEKPGTPGEGM	0.0
20:34297185-34297185 C>A	1.0	4335	COLORECTAL	-	-	-	-	RBM39	uc002xeb.3,p.V396F|uc010gfn.3,p.V239F|NM_001242599,p.V374F|ENST00000407261,p.V239F|uc002xeg.3,p.V374F|ENST00000528062,p.V374F|NM_184234,p.V396F|uc010zvn.2,p.V239F|ENST00000253363,p.V396F|uc002xee.3,p.V239F|uc002xed.3,p.V114F|uc002xdz.3,p.V372F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zvn.2	nonsynonymous SNV	exon14	c.G715T	p.V239F	SLAFGAVAEFSFVIDLQTRLSQQTE	SLAFGAVAEFSFFIDLQTRLSQQTE	10.0	3.0	-	-	4335_20:34297185-34297185 C>A_SLAFGAVAEFSFFIDLQTRLSQQTE	0.0
1:214813713-214813713 G>A	0.0	2591	MELANOMA	-	-	-	-	CENPF	NM_016343,p.E678K|uc001hkm.3,p.E678K|ENST00000366955,p.E678K	protein_coding, processed_transcript	uc001hkm.3	nonsynonymous SNV	exon12	c.G2032A	p.E678K	RTLEMDRENLSVEIRNLHNVLDSKS	RTLEMDRENLSVKIRNLHNVLDSKS	9.0	5.0	-	-	2591_1:214813713-214813713 G>A_RTLEMDRENLSVKIRNLHNVLDSKS	0.0
2:177036373-177036373 C>T	0.0	4298	COLORECTAL	-	-	-	-	HOXD3	ENST00000410016,p.R224C|ENST00000249440,p.R224C|uc002ukt.1,p.R224C|ENST00000468418,p.R224C|NM_006898,p.R224C	protein_coding, processed_transcript	uc002ukt.1	nonsynonymous SNV	exon3	c.C670T	p.R224C	EFHFNRYLCRPRRVEMANLLNLTER	EFHFNRYLCRPRCVEMANLLNLTER	2.0	8.0	-	-	4298_2:177036373-177036373 C>T_EFHFNRYLCRPRCVEMANLLNLTER	0.0
6:32322909-32322909 T>G	0.0	4213	COLORECTAL	-	-	-	-	C6orf10	NM_001286474,p.N84T|ENST00000533191,p.N84T|uc011dpz.2,p.N84T|ENST00000375015,p.N84T|uc021yvu.1,p.N84T	protein_coding	uc021yvu.1	nonsynonymous SNV	exon8	c.A251C	p.N84T	RERSKRDYTPSTNSLALSRSSIALP	RERSKRDYTPSTTSLALSRSSIALP	1.0	3.0	-	-	4213_6:32322909-32322909 T>G_RERSKRDYTPSTTSLALSRSSIALP	0.0
3:69988295-69988295 C>T	1.0	3784	MELANOMA	-	-	-	1	MITF	uc011bgb.2,p.P158L|NM_198158,p.P103L|ENST00000448226,p.P210L|uc003doe.3,p.P103L|uc003dob.3,p.P194L|ENST00000451708,p.P194L|NM_198178,p.P47L|ENST00000328528,p.P209L|ENST00000472437,p.P158L|ENST00000314557,p.P103L|ENST00000352241,p.P210L|uc021xam.1,p.P47L|NM_198159,p.P210L|NM_000248,p.P103L|uc003doa.3,p.P209L|uc003dnz.3,p.P210L|NM_001184967,p.P158L|ENST00000394355,p.P185L|uc003dof.3,p.P103L|ENST00000433517,p.P102L|ENST00000531774,p.P47L|NM_006722,p.P209L|ENST00000314589,p.P194L|ENST00000394351,p.P103L|NM_198177,p.P194L	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xam.1	nonsynonymous SNV	exon3	c.C140T	p.P47L	KFEEQNRAESECPGMNTHSRASCMQ	KFEEQNRAESECLGMNTHSRASCMQ	10.0	2.0	-	-	3784_3:69988295-69988295 C>T_KFEEQNRAESECLGMNTHSRASCMQ	0.0
16:21261309-21261309 A>C	1.0	4345	COLORECTAL	-	-	-	-	ANKS4B	ENST00000311620,p.K141T|uc010bwp.1,p.K141T|NM_145865,p.K141T	protein_coding	uc010bwp.1	nonsynonymous SNV	exon2	c.A422C	p.K141T	PKKVTRLKEQAQKNARRQIKECERL	PKKVTRLKEQAQTNARRQIKECERL	5.0	3.0	-	-	4345_16:21261309-21261309 A>C_PKKVTRLKEQAQTNARRQIKECERL	0.0
16:53691499-53691499 C>A	1.0	4345	COLORECTAL	-	-	-	-	RPGRIP1L	uc010vgy.2,p.V483L|ENST00000563746,p.V483L|uc010cbx.3,p.V483L|NM_001127897,p.V483L|ENST00000379925,p.V483L|NM_015272,p.V483L|ENST00000564374,p.V483L|ENST00000262135,p.V483L|uc002eho.4,p.V483L|uc002ehp.3,p.V483L|uc010vgz.1,p.V483L	retained_intron, protein_coding, processed_transcript	uc010vgz.1	nonsynonymous SNV	exon13	c.G1447T	p.V483L	EQKNGDLSFLVKVDSEINKDLERSM	EQKNGDLSFLVKLDSEINKDLERSM	6.0	10.0	-	-	4345_16:53691499-53691499 C>A_EQKNGDLSFLVKLDSEINKDLERSM	0.0
16:1816385-1816385 C>T	1.0	4189	MELANOMA	-	-	-	-	MAPK8IP3	NM_015133,p.P931S|uc010uvl.2,p.P932S|NM_001040439,p.P925S|ENST00000356010,p.P925S|uc021tah.1,p.P925S|ENST00000250894,p.P931S|uc002cmk.3,p.P931S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tah.1	nonsynonymous SNV	exon21	c.C2773T	p.P925S	LTEHVFTDPAPTPSSGPQPGSENGP	LTEHVFTDPAPTSSSGPQPGSENGP	8.0	8.0	-	-	4189_16:1816385-1816385 C>T_LTEHVFTDPAPTSSSGPQPGSENGP	0.0
9:22451852-22451852 G>T	0.0	4281	COLORECTAL	-	-	-	-	DMRTA1	NM_022160,p.S486I|ENST00000325870,p.S486I|uc003zpp.1,p.S486I	protein_coding	uc003zpp.1	nonsynonymous SNV	exon2	c.G1457T	p.S486I	FSGMIRDSSYLSSKDSITCGRLYFR	FSGMIRDSSYLSIKDSITCGRLYFR	3.0	10.0	-	-	4281_9:22451852-22451852 G>T_FSGMIRDSSYLSIKDSITCGRLYFR	0.0
16:4802625-4802625 G>A	1.0	3879	MELANOMA	-	-	-	-	ZNF500	uc002cxo.1,p.H191Y|ENST00000545009,p.H399Y|NM_021646,p.H399Y|uc002cxp.1,p.H399Y|uc010uxt.1,p.H399Y|ENST00000219478,p.H399Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc010uxt.1	nonsynonymous SNV	exon6	c.C1195T	p.H399Y	GKRFSQSSSLVIHRRTHSGERPYAC	GKRFSQSSSLVIYRRTHSGERPYAC	6.0	8.0	-	-	3879_16:4802625-4802625 G>A_GKRFSQSSSLVIYRRTHSGERPYAC	0.0
3:121591404-121591404 C>G	1.0	2556	MELANOMA	-	-	ID=COSM4157173;OCCURENCE=1(thyroid)	-	EAF2	NM_018456,p.L169V|uc003eeo.3,p.L39V|ENST00000273668,p.L169V|uc003een.3,p.L169V|ENST00000451944,p.L169V	protein_coding, processed_transcript, nonsense_mediated_decay	uc003eeo.3	nonsynonymous SNV	exon4	c.C115G	p.L39V	DDIERELKAEASLMDQMSSCDSSSD	DDIERELKAEASVMDQMSSCDSSSD	5.0	6.0	-	-	2556_3:121591404-121591404 C>G_DDIERELKAEASVMDQMSSCDSSSD	0.0
20:20144845-20144845 T>G	0.0	4278	COLORECTAL	-	-	-	-	CFAP61	NM_001167816,p.F393C|ENST00000451767,p.F393C|ENST00000377306,p.F393C|ENST00000340348,p.F347C|uc010zsf.1,p.F393C|uc010zse.2,p.F393C|ENST00000245957,p.F393C|uc002wru.3,p.F393C|NM_015585,p.F393C|uc010gcw.2,p.F347C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zsf.1	nonsynonymous SNV	exon10	c.T1178G	p.F393C	YRGASAAFCIQLFCIDEKYEARSLD	YRGASAAFCIQLCCIDEKYEARSLD	4.0	3.0	-	-	4278_20:20144845-20144845 T>G_YRGASAAFCIQLCCIDEKYEARSLD	0.0
X:122866860-122866860 C>G	0.0	4186	BREAST	-	-	-	-	THOC2	ENST00000245838,p.A5P|ENST00000433883,p.A5P|ENST00000472687,p.A5P|NM_001081550,p.A5P|ENST00000355725,p.A5P|uc004etu.3,p.A5P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004etu.3	nonsynonymous SNV	exon1	c.G13C	p.A5P	MAAAAVVVPAEWIKNWE	MAAAPVVVPAEWIKNWE	8.0	10.0	-	-	4186_X:122866860-122866860 C>G_MAAAPVVVPAEWIKNWE	0.0
1:9801223-9801223 G>A	1.0	3713	MELANOMA	-	-	ID=COSM415207;OCCURENCE=1(urinary_tract)	-	CLSTN1	uc001aqh.3,p.S483F|ENST00000435891,p.S303F|ENST00000377298,p.S483F|uc010oag.2,p.S483F|ENST00000377288,p.S483F|uc001aqi.3,p.S473F|NM_014944,p.S473F|ENST00000361311,p.S473F|NM_001009566,p.S483F	protein_coding, processed_transcript	uc010oag.2	nonsynonymous SNV	exon10	c.C1448T	p.S483F	TLYVDGTSHEPFSVTEDYPLHPSKI	TLYVDGTSHEPFFVTEDYPLHPSKI	9.0	1.0	-	-	3713_1:9801223-9801223 G>A_TLYVDGTSHEPFFVTEDYPLHPSKI	0.0
11:61571221-61571221 T>C	1.0	4326	BREAST	-	-	-	-	FADS1	uc010rln.1,p.T217A|uc010rlm.2,p.T358A|uc001nsh.3,p.T217A|ENST00000539999,p.T87A|ENST00000542506,p.T217A|ENST00000350997,p.T358A|ENST00000536991,p.T49A|NM_013402,p.T358A|ENST00000433932,p.T217A	protein_coding, processed_transcript, nonsense_mediated_decay	uc010rln.1	nonsynonymous SNV	exon8	c.A649G	p.T217A	QRKKWVDLAWMITFYVRFFLTYVPL	QRKKWVDLAWMIAFYVRFFLTYVPL	8.0	3.0	-	-	4326_11:61571221-61571221 T>C_QRKKWVDLAWMIAFYVRFFLTYVPL	0.0
14:21762902-21762902 T>G	0.0	4160	COLORECTAL	-	-	-	-	RPGRIP1	ENST00000557771,p.F51C|ENST00000556336,p.F51C|ENST00000400017,p.F51C|ENST00000206660,p.F51C|NM_020366,p.F51C|uc001wag.3,p.F51C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wag.3	nonsynonymous SNV	exon2	c.T152G	p.F51C	SRMNREELEDSFFRLREDHMLVKEL	SRMNREELEDSFCRLREDHMLVKEL	3.0	3.0	-	-	4160_14:21762902-21762902 T>G_SRMNREELEDSFCRLREDHMLVKEL	0.0
7:44924376-44924376 T>C	1.0	3466	MELANOMA	-	-	-	-	PURB	uc003tme.3,p.D191G|ENST00000395699,p.D191G|NM_033224,p.D191G	protein_coding	uc003tme.3	nonsynonymous SNV	exon1	c.A572G	p.D191G	LIEFRDALAKLIDDYGGEDDELAGG	LIEFRDALAKLIGDYGGEDDELAGG	9.0	8.0	-	-	3466_7:44924376-44924376 T>C_LIEFRDALAKLIGDYGGEDDELAGG	0.0
5:80382676-80382676 G>A	0.0	3795	MELANOMA	-	-	-	-	RASGRF2	NM_006909,p.D432N|uc003kha.2,p.D432N|uc003khb.1,p.D260N|ENST00000503795,p.D432N|ENST00000265080,p.D432N	protein_coding, processed_transcript, nonsense_mediated_decay	uc003khb.1	nonsynonymous SNV	exon6	c.G778A	p.D260N	EELSRVMHDEVSDTENIRKNLAIER	EELSRVMHDEVSNTENIRKNLAIER	4.0	10.0	-	-	3795_5:80382676-80382676 G>A_EELSRVMHDEVSNTENIRKNLAIER	0.0
4:54218799-54218799 T>C	1.0	4245	COLORECTAL	-	-	-	-	SCFD2	ENST00000401642,p.N325D|ENST00000388940,p.N325D|NM_152540,p.N325D|uc003gzu.3,p.N325D|uc010igm.3,p.N325D	protein_coding	uc010igm.3	nonsynonymous SNV	exon2	c.A973G	p.N325D	ALTALHTEEENYNVVAPGCLSQSSD	ALTALHTEEENYDVVAPGCLSQSSD	7.0	5.0	-	-	4245_4:54218799-54218799 T>C_ALTALHTEEENYDVVAPGCLSQSSD	0.0
12:129559153-129559153 G>A	0.0	4095	COLORECTAL	-	-	-	-	TMEM132D	uc001uia.2,p.T394M|NM_133448,p.T856M|uc009zyl.1,p.T856M|ENST00000389441,p.T394M|ENST00000422113,p.T856M	protein_coding	uc009zyl.1	nonsynonymous SNV	exon9	c.C2567T	p.T856M	SSSMGLMEGRGTTTDRSILQKKKGQ	SSSMGLMEGRGTMTDRSILQKKKGQ	2.0	9.0	-	-	4095_12:129559153-129559153 G>A_SSSMGLMEGRGTMTDRSILQKKKGQ	0.0
14:52433353-52433353 C>T	0.0	4275	COLORECTAL	0.0005	-	ID=COSM123400;OCCURENCE=1(lung),1(central_nervous_system),1(upper_aerodigestive_tract)	-	GNG2	uc001wzi.3,p.P55L|ENST00000555472,p.P55L|uc021rte.1,p.P55L|NM_001243773,p.P55L|uc001wzk.3,p.P55L|ENST00000556766,p.P55L|ENST00000554736,p.P55L|uc001wzj.3,p.P55L|ENST00000553432,p.P86L|NM_053064,p.P55L|ENST00000556752,p.P55L|ENST00000557376,p.P94L|ENST00000335281,p.P55L|NM_001243774,p.P55L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021rte.1	nonsynonymous SNV	exon4	c.C164T	p.P55L	AHAKEDPLLTPVPASENPFREKKFF	AHAKEDPLLTPVLASENPFREKKFF	6.0	6.0	-	-	4275_14:52433353-52433353 C>T_AHAKEDPLLTPVLASENPFREKKFF	0.0
12:113402091-113402091 G>A	1.0	4000	MELANOMA	-	-	-	-	OAS3	ENST00000228928,p.E761K|NM_006187,p.E761K|uc001tug.3,p.E761K	retained_intron, protein_coding, processed_transcript	uc001tug.3	nonsynonymous SNV	exon11	c.G2281A	p.E761K	QTPAGDLDKFISEFLQPNRQFLAQV	QTPAGDLDKFISKFLQPNRQFLAQV	9.0	10.0	-	-	4000_12:113402091-113402091 G>A_QTPAGDLDKFISKFLQPNRQFLAQV	0.0
15:89382166-89382166 G>A	0.0	3775	CERVICAL	-	-	-	-	ACAN	uc010upp.1,p.D115N|ENST00000561243,p.D115N|ENST00000558207,p.D115N|NM_013227,p.D115N|uc010upo.1,p.D115N|ENST00000439576,p.D115N|NM_001135,p.D115N|uc002bmx.3,p.D115N|ENST00000352105,p.D115N|ENST00000559004,p.D115N	retained_intron, protein_coding	uc010upp.1	nonsynonymous SNV	exon3	c.G343A	p.D115N	KVSLPNYPAIPSDATLEVQSLRSND	KVSLPNYPAIPSNATLEVQSLRSND	4.0	9.0	-	-	3775_15:89382166-89382166 G>A_KVSLPNYPAIPSNATLEVQSLRSND	0.0
4:73957853-73957853 G>A	1.0	4189	MELANOMA	-	-	-	-	ANKRD17	uc003hgr.3,p.S1830F|ENST00000330838,p.S1580F|uc003hgp.3,p.S1831F|uc003hgq.3,p.S1580F|NM_001286771,p.S1718F|ENST00000509867,p.S1718F|NM_032217,p.S1831F|NM_198889,p.S1580F|ENST00000358602,p.S1831F|uc003hgo.3,p.S1718F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003hgr.3	nonsynonymous SNV	exon29	c.C5489T	p.S1830F	GSSAPTTTAANTSLMGIKMTTVALS	GSSAPTTTAANTFLMGIKMTTVALS	10.0	1.0	-	-	4189_4:73957853-73957853 G>A_GSSAPTTTAANTFLMGIKMTTVALS	0.0
X:118723545-118723545 G>A	1.0	4266	COLORECTAL	-	-	ID=COSM1113886,COSM1598786;OCCURENCE=1(endometrium)	-	NKRF	ENST00000542113,p.R630C|NM_001173488,p.R615C|uc004erq.3,p.R615C|NM_017544,p.R615C|ENST00000304449,p.R615C|uc022cdk.1,p.R630C|NM_001173487,p.R630C|uc004err.3,p.R615C|ENST00000371527,p.R615C	protein_coding, processed_transcript	uc022cdk.1	nonsynonymous SNV	exon4	c.C1888T	p.R630C	KRDIEQIIRNYARSESHTDLTFSRE	KRDIEQIIRNYACSESHTDLTFSRE	6.0	3.0	-	-	4266_X:118723545-118723545 G>A_KRDIEQIIRNYACSESHTDLTFSRE	0.0
10:50315822-50315822 G>A	0.0	4278	COLORECTAL	-	-	-	-	VSTM4	NM_144984,p.R92C|ENST00000332853,p.R92C|uc001jhf.2,p.R92C|uc001jhh.2,p.R92C|NM_001031746,p.R92C|ENST00000298454,p.R92C	protein_coding, processed_transcript	uc001jhh.2	nonsynonymous SNV	exon2	c.C274T	p.R92C	KLRVVQYYGNFSRSAKRRRLRLLEE	KLRVVQYYGNFSCSAKRRRLRLLEE	4.0	7.0	-	-	4278_10:50315822-50315822 G>A_KLRVVQYYGNFSCSAKRRRLRLLEE	0.0
9:139976454-139976454 C>T	1.0	3713	MELANOMA	-	-	-	-	UAP1L1	ENST00000409858,p.P457S|uc010ncb.3,p.P457S|uc004cla.4,p.P334S|NM_207309,p.P457S|ENST00000360271,p.P334S	retained_intron, protein_coding, processed_transcript	uc010ncb.3	nonsynonymous SNV	exon8	c.C1369T	p.P457S	AHGAWLPELPSLPPNGDPPAICEIS	AHGAWLPELPSLSPNGDPPAICEIS	8.0	4.0	-	-	3713_9:139976454-139976454 C>T_AHGAWLPELPSLSPNGDPPAICEIS	0.0
4:20535275-20535275 C>T	0.0	4069	PANCREATIC	0.0005	-	-	-	SLIT2	ENST00000503823,p.T582M|uc003gpr.1,p.T590M|NM_004787,p.T590M|uc003gps.1,p.T582M|NM_001289135,p.T586M|ENST00000504154,p.T590M|ENST00000273739,p.T594M|ENST00000503837,p.T586M|NM_001289136,p.T582M	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon17	c.C1745T	p.T582M	FEGASGVNEILLTSNRLENVQHKMF	FEGASGVNEILLMSNRLENVQHKMF	5.0	4.0	-	-	4069_4:20535275-20535275 C>T_FEGASGVNEILLMSNRLENVQHKMF	0.0
17:64785081-64785081 C>T	1.0	3713	MELANOMA	-	-	-	-	PRKCA	ENST00000413366,p.P613L|NM_002737,p.P613L|uc002jfp.1,p.P613L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002jfp.1	nonsynonymous SNV	exon16	c.C1838T	p.P613L	DWEKLENREIQPPFKPKVCGKGAEN	DWEKLENREIQPLFKPKVCGKGAEN	6.0	10.0	-	-	3713_17:64785081-64785081 C>T_DWEKLENREIQPLFKPKVCGKGAEN	0.0
X:56310789-56310789 A>T	0.0	4259	COLORECTAL	-	-	-	-	KLF8	uc004dur.3,p.K314N|ENST00000468660,p.K314N|NM_007250,p.K314N|uc031tjs.1,p.K230N	retained_intron, protein_coding, nonsense_mediated_decay	uc031tjs.1	nonsynonymous SNV	exon4	c.A690T	p.K230N	KPYKCTWDGCSWKFARSDELTRHFR	KPYKCTWDGCSWNFARSDELTRHFR	4.0	4.0	-	-	4259_X:56310789-56310789 A>T_KPYKCTWDGCSWNFARSDELTRHFR	0.0
5:13901543-13901543 C>T	0.0	4346	COLORECTAL	-	-	-	-	DNAH5	NM_001369,p.A624T|uc003jfd.2,p.A624T|ENST00000265104,p.A624T	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon14	c.G1870A	p.A624T	YDPPLARNQPPIAGKILWARQLFHR	YDPPLARNQPPITGKILWARQLFHR	4.0	7.0	-	-	4346_5:13901543-13901543 C>T_YDPPLARNQPPITGKILWARQLFHR	0.0
22:50944502-50944502 G>A	1.0	4155	MELANOMA	-	-	-	-	LMF2	uc003blo.2,p.P221S|uc003blp.2,p.P246S|NM_033200,p.P246S|ENST00000216080,p.P221S|ENST00000380796,p.P246S|ENST00000474879,p.P246S	retained_intron, protein_coding, processed_transcript	uc003blp.2	nonsynonymous SNV	exon5	c.C736T	p.P246S	LIEIAVPPLFFAPIRRLRLAAFYSQ	LIEIAVPPLFFASIRRLRLAAFYSQ	10.0	7.0	-	-	4155_22:50944502-50944502 G>A_LIEIAVPPLFFASIRRLRLAAFYSQ	0.0
15:45657018-45657018 G>A	1.0	3879	MELANOMA	-	-	-	-	GATM	uc001zvb.3,p.P211L|ENST00000558336,p.P340L|uc010uev.1,p.P393L|ENST00000396659,p.P340L|uc001zvc.3,p.P340L|NM_001482,p.P340L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uev.1	nonsynonymous SNV	exon7	c.C1178T	p.P393L	DLFKKAGWTIITPPTPIIPDDHPLW	DLFKKAGWTIITLPTPIIPDDHPLW	5.0	9.0	-	-	3879_15:45657018-45657018 G>A_DLFKKAGWTIITLPTPIIPDDHPLW	0.0
19:58879856-58879856 G>A	1.0	4281	COLORECTAL	-	-	-	-	ZNF837	ENST00000597582,p.R282C|NM_138466,p.R282C|ENST00000427624,p.R282C|uc002qsl.4,p.R282C|uc021vcx.1,p.R282C|uc002qsm.3,p.R282C	protein_coding	uc021vcx.1	nonsynonymous SNV	exon1	c.C844T	p.R282C	LYACDECGKAFTRTSSLLQHQRIHT	LYACDECGKAFTCTSSLLQHQRIHT	5.0	5.0	-	-	4281_19:58879856-58879856 G>A_LYACDECGKAFTCTSSLLQHQRIHT	0.0
10:92508939-92508939 T>C	0.0	4281	COLORECTAL	-	-	-	-	HTR7	ENST00000277874,p.I318V|uc001kgz.3,p.I318V|ENST00000371719,p.I318V|ENST00000371721,p.I318V|NM_019859,p.I318V|uc001kha.3,p.I318V|ENST00000336152,p.I318V|NM_000872,p.I318V|NM_019860,p.I318V|uc001khb.3,p.I318V	protein_coding	uc001khb.3	nonsynonymous SNV	exon2	c.A952G	p.I318V	SRLLKHERKNISIFKREQKAATTLG	SRLLKHERKNISVFKREQKAATTLG	2.0	8.0	-	-	4281_10:92508939-92508939 T>C_SRLLKHERKNISVFKREQKAATTLG	0.0
3:42597481-42597481 G>A	1.0	3713	MELANOMA	-	-	-	-	SEC22C	ENST00000264454,p.H218Y|ENST00000417572,p.H218Y|NM_032970,p.H218Y|uc003cli.3,p.H218Y|uc011azo.2,p.H148Y|uc003clj.3,p.H218Y|NM_004206,p.H218Y|ENST00000456515,p.H218Y|ENST00000536332,p.H148Y|NM_001201572,p.H218Y|ENST00000273156,p.H218Y|uc003clh.3,p.H218Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011azo.2	nonsynonymous SNV	exon7	c.C442T	p.H148Y	GVHLAEHSLQVAHEEIGNILAFLVP	GVHLAEHSLQVAYEEIGNILAFLVP	9.0	8.0	CD8	-	3713_3:42597481-42597481 G>A_GVHLAEHSLQVAYEEIGNILAFLVP	1.0
19:39068825-39068825 G>T	1.0	4234	NSCLC	-	-	-	-	RYR1	NM_001042723,p.G4777V|ENST00000360985,p.G4777V|ENST00000359596,p.G4782V|uc002oit.3,p.G4782V|uc002oiu.3,p.G4777V|NM_000540,p.G4782V|ENST00000355481,p.G4777V	retained_intron, protein_coding, nonsense_mediated_decay	uc002oiu.3	nonsynonymous SNV	exon98	c.G14330T	p.G4777V	MSIDVKYQIWKFGVIFTDNSFLYLG	MSIDVKYQIWKFVVIFTDNSFLYLG	7.0	1.0	-	-	4234_19:39068825-39068825 G>T_MSIDVKYQIWKFVVIFTDNSFLYLG	0.0
5:90079758-90079758 C>T	0.0	3795	MELANOMA	-	-	-	-	GPR98	uc003kju.3,p.P4513S|NM_032119,p.P4513S|ENST00000405460,p.P4513S|uc003kjw.3,p.P174S|ENST00000425867,p.P174S	retained_intron, protein_coding, processed_transcript	uc003kjw.3	nonsynonymous SNV	exon3	c.C520T	p.P174S	LVSRIIIAKSDSPFGVIRFLNQSKI	LVSRIIIAKSDSSFGVIRFLNQSKI	5.0	10.0	-	-	3795_5:90079758-90079758 C>T_LVSRIIIAKSDSSFGVIRFLNQSKI	0.0
11:111853103-111853103 G>A	1.0	4326	BREAST	-	-	-	-	DIXDC1	uc001pmm.3,p.G59E|uc001pml.3,p.G270E	retained_intron, protein_coding, processed_transcript	uc001pmm.3	nonsynonymous SNV	exon3	c.G176A	p.G59E	GTDSPLSRDWRPGSPGTYLETSWEE	GTDSPLSRDWRPESPGTYLETSWEE	8.0	7.0	-	-	4326_11:111853103-111853103 G>A_GTDSPLSRDWRPESPGTYLETSWEE	0.0
9:123902994-123902994 C>T	1.0	4329	COLORECTAL	0.0005	-	-	1	CNTRL	uc004bky.1,p.R409C|NM_007018,p.R805C|ENST00000373855,p.R805C|ENST00000238341,p.R805C|uc004bkz.1,p.R253C|ENST00000373850,p.R253C|uc004bla.1,p.R253C|ENST00000373847,p.R253C|uc004bkx.1,p.R805C	protein_coding, processed_transcript	uc004bla.1	nonsynonymous SNV	exon6	c.C757T	p.R253C	QNHLNHVVDGLVRPEEVAARVDELR	QNHLNHVVDGLVCPEEVAARVDELR	7.0	8.0	-	-	4329_9:123902994-123902994 C>T_QNHLNHVVDGLVCPEEVAARVDELR	0.0
X:47082985-47082985 A>G	1.0	4320	COLORECTAL	-	-	-	-	CDK16	NM_001170460,p.Q84R|ENST00000276052,p.Q84R|uc011mll.2,p.Q84R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mll.2	nonsynonymous SNV	exon2	c.A251G	p.Q84R	QIAMDRMKKIKRQLSMTLRGGRGID	QIAMDRMKKIKRRLSMTLRGGRGID	10.0	1.0	-	-	4320_X:47082985-47082985 A>G_QIAMDRMKKIKRRLSMTLRGGRGID	0.0
15:78526785-78526785 T>G	0.0	4298	COLORECTAL	-	-	-	-	ACSBG1	NM_015162,p.D20A|ENST00000560124,p.D20A|ENST00000258873,p.D20A|uc002bdh.3,p.D20A|uc010umw.2,p.D20A|ENST00000558130,p.D20A|NM_001199377,p.D20A|ENST00000559707,p.D20A|ENST00000557935,p.D20A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010umw.2	nonsynonymous SNV	exon1	c.A59C	p.D20A	GYGCPHGDPSMLDSRETPQESRQDM	GYGCPHGDPSMLASRETPQESRQDM	2.0	4.0	-	-	4298_15:78526785-78526785 T>G_GYGCPHGDPSMLASRETPQESRQDM	0.0
3:97983843-97983843 T>C	0.0	4110	BILE DUCT	-	-	-	-	OR5H6	uc003dsi.1,p.F239L|NM_001005479,p.F239L|ENST00000383696,p.F239L	protein_coding	uc003dsi.1	nonsynonymous SNV	exon1	c.T715C	p.F239L	IGTILISYTIILFTILEKKSIKGIR	IGTILISYTIILLTILEKKSIKGIR	1.0	5.0	-	-	4110_3:97983843-97983843 T>C_IGTILISYTIILLTILEKKSIKGIR	0.0
16:57608879-57608879 A>G	0.0	4077	BILE DUCT	-	-	-	-	GPR114	uc010vhr.2,p.M415V	retained_intron, protein_coding, processed_transcript	uc010vhr.2	nonsynonymous SNV	exon10	c.A1243G	p.M415V	GSGRMHQVSGPAMTLSLCWASPCCW	GSGRMHQVSGPAVTLSLCWASPCCW	4.0	4.0	-	-	4077_16:57608879-57608879 A>G_GSGRMHQVSGPAVTLSLCWASPCCW	0.0
14:21463019-21463019 G>A	1.0	3775	CERVICAL	-	-	ID=COSM432821;OCCURENCE=1(breast)	-	METTL17	uc001vyo.3,p.E279K|ENST00000339374,p.E279K|uc001vym.3,p.E279K|uc001vyn.3,p.E279K|ENST00000556670,p.E279K|NM_022734,p.E279K|NM_001029991,p.E279K|ENST00000382985,p.E279K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001vyo.3	nonsynonymous SNV	exon9	c.G835A	p.E279K	SLSELPSKADRTEVVQTLWRKTGHF	SLSELPSKADRTKVVQTLWRKTGHF	10.0	10.0	CD8	-	3775_14:21463019-21463019 G>A_SLSELPSKADRTKVVQTLWRKTGHF	1.0
3:112282377-112282377 G>A	1.0	4213	COLORECTAL	-	-	-	-	SLC35A5	ENST00000468642,p.E43K|ENST00000261034,p.E43K|NM_017945,p.E43K|uc003dze.4,p.E43K|ENST00000492406,p.E43K|ENST00000484995,p.E43K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003dze.4	nonsynonymous SNV	exon2	c.G127A	p.E43K	SSRILLVKYSANEENKYDYLPTTVN	SSRILLVKYSANKENKYDYLPTTVN	8.0	5.0	-	-	4213_3:112282377-112282377 G>A_SSRILLVKYSANKENKYDYLPTTVN	0.0
13:115090798-115090798 C>T	1.0	3919	MELANOMA	-	-	-	-	CHAMP1	NM_032436,p.P494L|uc010ahb.3,p.P494L|uc021rmx.1,p.P494L|uc010tko.2,p.P494L|NM_001164144,p.P494L|uc001vuv.3,p.P494L|ENST00000361283,p.P494L|NM_001164145,p.P494L	protein_coding, processed_transcript	uc021rmx.1	nonsynonymous SNV	exon1	c.C1481T	p.P494L	SSFFIEPQKPVFPETRKPGPSGPSE	SSFFIEPQKPVFLETRKPGPSGPSE	10.0	7.0	-	-	3919_13:115090798-115090798 C>T_SSFFIEPQKPVFLETRKPGPSGPSE	0.0
X:47836253-47836253 G>T	1.0	3919	MELANOMA	-	-	-	-	ZNF182	NM_006962,p.F411L|NM_001178099,p.F411L|ENST00000305127,p.F411L|ENST00000376943,p.F392L|uc004dir.3,p.F411L|NM_001007088,p.F392L|uc004dis.3,p.F392L|uc004dit.3,p.F411L|ENST00000396965,p.F411L	protein_coding	uc004dit.3	nonsynonymous SNV	exon7	c.C1233A	p.F411L	EKPHKCTECGKSFNEKSTLIVHQRT	EKPHKCTECGKSLNEKSTLIVHQRT	4.0	9.0	-	-	3919_X:47836253-47836253 G>T_EKPHKCTECGKSLNEKSTLIVHQRT	0.0
6:136500196-136500196 G>A	1.0	3713	MELANOMA	-	-	-	-	PDE7B	ENST00000308191,p.E289K|NM_018945,p.E289K|uc003qgr.3,p.E341K|uc003qgp.3,p.E289K	protein_coding	uc003qgr.3	nonsynonymous SNV	exon9	c.G1021A	p.E341K	SLILATDINRQNEFLTRLKAHLHNK	SLILATDINRQNKFLTRLKAHLHNK	2.0	10.0	-	-	3713_6:136500196-136500196 G>A_SLILATDINRQNKFLTRLKAHLHNK	0.0
11:67168211-67168211 C>T	1.0	2359	MELANOMA	-	-	-	-	PPP1CA	ENST00000358239,p.G79R|uc001okx.1,p.G211R|ENST00000527663,p.G123R|NM_206873,p.G79R|uc001oku.1,p.G134R|uc001okw.1,p.G123R|ENST00000376745,p.G123R|uc001okv.1,p.G79R|NM_001008709,p.G134R|NM_002708,p.G123R|ENST00000312989,p.G134R	retained_intron, protein_coding, processed_transcript	uc001okx.1	nonsynonymous SNV	exon4	c.G631A	p.G211R	KIKYPENFFLLRGNHECASINRIYG	KIKYPENFFLLRRNHECASINRIYG	10.0	4.0	-	-	2359_11:67168211-67168211 C>T_KIKYPENFFLLRRNHECASINRIYG	0.0
18:61600354-61600354 G>T	0.0	4266	COLORECTAL	-	-	-	-	SERPINB10	ENST00000238508,p.A236S|uc010xew.2,p.A236S|NM_005024,p.A236S|uc010xev.2,p.A236S	protein_coding	uc010xew.2	nonsynonymous SNV	exon6	c.G706T	p.A236S	KKLHIFHIEKPKAVGLQLYYKSRDL	KKLHIFHIEKPKSVGLQLYYKSRDL	1.0	6.0	-	-	4266_18:61600354-61600354 G>T_KKLHIFHIEKPKSVGLQLYYKSRDL	0.0
19:41930509-41930509 A>C	0.0	4081	COLORECTAL	-	-	-	-	BCKDHA	ENST00000457836,p.K448T|uc002oqq.3,p.K445T|ENST00000595085,p.K479T|uc002oqm.4,p.K479T|uc010xvz.2,p.K448T|NM_001164783,p.K444T|NM_000709,p.K445T|ENST00000540732,p.K479T|ENST00000269980,p.K445T|uc002oqr.3,p.K444T	 protein_coding, processed_transcript,retained_intron	uc010xvz.2	nonsynonymous SNV	exon9	c.A1343C	p.K448T	TYGEHYPLDHFDK	TYGEHYPLDHFDT	5.0	3.0	-	-	4081_19:41930509-41930509 A>C_TYGEHYPLDHFDT	0.0
8:27097502-27097502 G>A	0.0	4298	COLORECTAL	-	-	-	-	STMN4	ENST00000519614,p.R166W|uc010luo.3,p.R166W|uc011lak.2,p.R193W|ENST00000522908,p.R193W	retained_intron, protein_coding	uc011lak.2	nonsynonymous SNV	exon6	c.C577T	p.R193W	ENREAHLAAMLERLQEKVRGPWLER	ENREAHLAAMLEWLQEKVRGPWLER	2.0	7.0	-	-	4298_8:27097502-27097502 G>A_ENREAHLAAMLEWLQEKVRGPWLER	0.0
21:30325541-30325541 G>C	1.0	2556	MELANOMA	-	-	-	-	LTN1	NM_015565,p.N1125K|ENST00000389194,p.N1125K|ENST00000361371,p.N1079K|uc002ymr.2,p.N1125K	protein_coding, processed_transcript	uc002ymr.2	nonsynonymous SNV	exon17	c.C3375G	p.N1125K	LGNTSGLLQLLFNRSREHGTLWSLI	LGNTSGLLQLLFKRSREHGTLWSLI	7.0	6.0	-	-	2556_21:30325541-30325541 G>C_LGNTSGLLQLLFKRSREHGTLWSLI	0.0
2:101611938-101611938 C>T	1.0	2591	MELANOMA	-	-	-	-	NPAS2	ENST00000335681,p.T790I|NM_002518,p.T790I|uc002tap.1,p.T790I|uc010yvt.1,p.T855I|ENST00000542504,p.T855I	retained_intron, protein_coding, processed_transcript	uc010yvt.1	nonsynonymous SNV	exon21	c.C2564T	p.T855I	SLLLSTYSQQPGTLGYPQPPPAQPQ	SLLLSTYSQQPGILGYPQPPPAQPQ	9.0	10.0	-	-	2591_2:101611938-101611938 C>T_SLLLSTYSQQPGILGYPQPPPAQPQ	0.0
3:185329500-185329500 G>A	1.0	4095	COLORECTAL	-	-	-	-	SENP2	NM_021627,p.G262R|ENST00000545472,p.G252R|uc003fpn.3,p.G262R|ENST00000296257,p.G262R|uc011brw.2,p.G75R|ENST00000427465,p.G86R|uc011brv.2,p.G252R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011brw.2	nonsynonymous SNV	exon7	c.G223A	p.G75R	LKTKGWGEEQNHGVKTTQFVPKQYR	LKTKGWGEEQNHRVKTTQFVPKQYR	9.0	8.0	-	-	4095_3:185329500-185329500 G>A_LKTKGWGEEQNHRVKTTQFVPKQYR	0.0
18:61390297-61390297 A>C	0.0	4298	COLORECTAL	-	-	-	-	SERPINB11	uc010dqd.3,p.E167D|NM_001291279,p.E106D|uc002ljj.4,p.E167D|uc010xes.2,p.E106D|ENST00000536691,p.E106D|uc010dqe.3,p.E80D|ENST00000538847,p.E79D|uc010dqf.3,p.E79D	protein_coding, processed_transcript, polymorphic_pseudogene	uc010xes.2	nonsynonymous SNV	exon7	c.A318C	p.E106D	HEWTSSSNMMEREVEVHLPRFKLET	HEWTSSSNMMERDVEVHLPRFKLET	1.0	6.0	-	-	4298_18:61390297-61390297 A>C_HEWTSSSNMMERDVEVHLPRFKLET	0.0
11:32954080-32954080 C>T	1.0	3678	MELANOMA	-	-	-	-	QSER1	uc001mty.3,p.P297S|ENST00000399302,p.P297S|NM_001076786,p.P297S	retained_intron, protein_coding, processed_transcript	uc001mty.3	nonsynonymous SNV	exon4	c.C889T	p.P297S	TEQPLTSTKTPKPQSIIPPVQTLSY	TEQPLTSTKTPKSQSIIPPVQTLSY	9.0	2.0	-	-	3678_11:32954080-32954080 C>T_TEQPLTSTKTPKSQSIIPPVQTLSY	0.0
1:92161261-92161261 G>A	0.0	4346	COLORECTAL	-	-	-	-	TGFBR3	ENST00000465892,p.T801M|NM_001195683,p.T801M|uc001doi.3,p.T801M|NM_001195684,p.T801M|uc010osy.2,p.T760M|NM_003243,p.T802M|ENST00000212355,p.T802M|uc001doj.3,p.T801M|uc009wde.3,p.T497M|uc001doh.3,p.T802M|ENST00000370399,p.T801M|ENST00000525962,p.T802M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010osy.2	nonsynonymous SNV	exon17	c.C2279T	p.T760M	IAFAAFVIGALLTGALWYIYSHTGE	IAFAAFVIGALLMGALWYIYSHTGE	8.0	3.0	-	-	4346_1:92161261-92161261 G>A_IAFAAFVIGALLMGALWYIYSHTGE	0.0
21:43327206-43327206 C>T	1.0	3678	MELANOMA	-	-	-	-	C2CD2	uc002yzx.1,p.E250K|NM_015500,p.E405K|uc002yzt.3,p.E21K|uc002yzv.3,p.E250K|NM_199050,p.E250K|ENST00000380486,p.E405K|uc002yzw.3,p.E405K|uc002yzu.3,p.E237K|ENST00000329623,p.E250K	retained_intron, protein_coding, processed_transcript	uc002yzx.1	nonsynonymous SNV	exon9	c.G748A	p.E250K	WPIPPPVPAAKIEKDRTVMPCGTVV	WPIPPPVPAAKIKKDRTVMPCGTVV	7.0	4.0	-	-	3678_21:43327206-43327206 C>T_WPIPPPVPAAKIKKDRTVMPCGTVV	0.0
22:38203981-38203981 C>T	1.0	4301	MELANOMA	-	-	-	-	GCAT	ENST00000248924,p.P3S|ENST00000445195,p.P3S|ENST00000323205,p.P3S|NM_001171690,p.P3S|uc003aua.2,p.P3S|ENST00000426858,p.P3S|uc003atz.3,p.P3S|NM_014291,p.P3S	retained_intron, protein_coding, nonsense_mediated_decay	uc003aua.2	nonsynonymous SNV	exon1	c.C7T	p.P3S	MWPGNAWRAALFWVP	MWSGNAWRAALFWVP	7.0	8.0	-	-	4301_22:38203981-38203981 C>T_MWSGNAWRAALFWVP	0.0
15:54305692-54305692 T>C	0.0	4298	COLORECTAL	-	-	-	-	UNC13C	ENST00000537900,p.S198P|ENST00000545554,p.S198P|NM_001080534,p.S198P|uc021sms.1,p.S198P|ENST00000260323,p.S198P|uc021smr.1,p.S198P	retained_intron, protein_coding	uc021sms.1	nonsynonymous SNV	exon1	c.T592C	p.S198P	KWKKSQECVSSDSELSTMKKSWGIR	KWKKSQECVSSDPELSTMKKSWGIR	2.0	1.0	-	-	4298_15:54305692-54305692 T>C_KWKKSQECVSSDPELSTMKKSWGIR	0.0
17:33749015-33749015 C>T	1.0	3713	MELANOMA	-	-	-	-	SLFN12	ENST00000452764,p.E345K|ENST00000304905,p.E345K|uc010cts.3,p.E345K|uc002hjj.4,p.E345K|NM_001289009,p.E345K|uc002hji.4,p.E345K|ENST00000394562,p.E345K|NM_018042,p.E345K	retained_intron, protein_coding, processed_transcript	uc010cts.3	nonsynonymous SNV	exon2	c.G1033A	p.E345K	TRKEWIQFMVEAEPKFSSSYEEVIS	TRKEWIQFMVEAKPKFSSSYEEVIS	5.0	10.0	-	-	3713_17:33749015-33749015 C>T_TRKEWIQFMVEAKPKFSSSYEEVIS	0.0
2:157427713-157427713 C>T	1.0	4000	MELANOMA	-	-	-	-	GPD2	ENST00000409674,p.A559V|ENST00000409861,p.A559V|uc002tzd.4,p.A559V|uc002tzf.4,p.A559V|NM_000408,p.A559V|NM_001083112,p.A559V|ENST00000409125,p.A332V|uc010zch.2,p.A332V|ENST00000310454,p.A559V|ENST00000438166,p.A559V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zch.2	nonsynonymous SNV	exon9	c.C995T	p.A332V	TAVDMISRRTRLAFLNVQAAEEALP	TAVDMISRRTRLVFLNVQAAEEALP	9.0	9.0	CD8	-	4000_2:157427713-157427713 C>T_TAVDMISRRTRLVFLNVQAAEEALP	1.0
1:248737554-248737554 T>C	0.0	4160	COLORECTAL	-	-	-	-	OR2T34	ENST00000328782,p.M169V|uc001iep.1,p.M169V|NM_001001821,p.M169V	protein_coding	uc001iep.1	nonsynonymous SNV	exon1	c.A505G	p.M169V	GMVDGLLLTPITMSFPFCQSRKILS	GMVDGLLLTPITVSFPFCQSRKILS	1.0	2.0	-	-	4160_1:248737554-248737554 T>C_GMVDGLLLTPITVSFPFCQSRKILS	0.0
1:233225846-233225846 G>A	1.0	3466	MELANOMA	-	-	-	-	PCNXL2	uc001hvl.2,p.S1346L|ENST00000258229,p.S1346L|NM_014801,p.S1346L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001hvl.2	nonsynonymous SNV	exon23	c.C4037T	p.S1346L	LSPFLGSVIFITSYVRPVKFWEKNY	LSPFLGSVIFITLYVRPVKFWEKNY	9.0	4.0	-	-	3466_1:233225846-233225846 G>A_LSPFLGSVIFITLYVRPVKFWEKNY	0.0
9:125075619-125075619 C>T	1.0	3713	MELANOMA	-	-	-	-	MRRF	NM_138777,p.S222F|ENST00000373729,p.S178F|uc011lyr.2,p.S170F|ENST00000297908,p.S170F|NM_001173512,p.S170F|ENST00000344641,p.S222F|uc010mwa.3,p.S222F	protein_coding, nonsense_mediated_decay	uc011lyr.2	nonsynonymous SNV	exon5	c.C509T	p.S170F	KVRTNSMNKLKKSKDTVSEDTIRLI	KVRTNSMNKLKKFKDTVSEDTIRLI	7.0	5.0	-	-	3713_9:125075619-125075619 C>T_KVRTNSMNKLKKFKDTVSEDTIRLI	0.0
13:36900820-36900820 T>A	0.0	4317	COLORECTAL	-	-	-	-	SPG20	uc010ten.2,p.S384C	protein_coding, processed_transcript	uc010ten.2	nonsynonymous SNV	exon4	c.A1150T	p.S384C	LDQGNKDAKDTSSEEVNLSHIVPCE	LDQGNKDAKDTSCEEVNLSHIVPCE	5.0	5.0	-	-	4317_13:36900820-36900820 T>A_LDQGNKDAKDTSCEEVNLSHIVPCE	0.0
16:111675-111675 G>A	1.0	4037	NSCLC	-	-	-	-	RHBDF1	ENST00000262316,p.L410F|uc010uty.2,p.L433F|ENST00000454039,p.L410F|NM_022450,p.L410F|uc002cfl.4,p.L410F|uc010utz.2,p.L410F	retained_intron, protein_coding, nonsense_mediated_decay	uc010utz.2	nonsynonymous SNV	exon9	c.C1228T	p.L410F	DMDDHRPFFTYWLTFVHSLVTILAV	DMDDHRPFFTYWFTFVHSLVTILAV	8.0	9.0	-	-	4037_16:111675-111675 G>A_DMDDHRPFFTYWFTFVHSLVTILAV	0.0
8:90965753-90965753 A>C	1.0	4252	COLORECTAL	-	-	-	1	NBN	ENST00000409330,p.L440V|ENST00000265433,p.L522V|NM_002485,p.L522V|uc003yej.1,p.L522V|uc011lgb.1,p.L522V|uc003yei.1,p.L440V	retained_intron, protein_coding, nonsense_mediated_decay	uc011lgb.1	nonsynonymous SNV	exon11	c.T1564G	p.L522V	ENEPVDTNSDNNLFTDTDLKSIVKN	ENEPVDTNSDNNVFTDTDLKSIVKN	8.0	3.0	-	-	4252_8:90965753-90965753 A>C_ENEPVDTNSDNNVFTDTDLKSIVKN	0.0
2:130897612-130897612 C>T	1.0	3795	MELANOMA	-	-	-	-	CCDC74B	NM_001258307,p.E246K|ENST00000409943,p.E246K|uc002tqm.2,p.E312K|NM_207310,p.E312K|uc010yzw.2,p.E414K|uc002tqn.2,p.E246K|ENST00000392984,p.E414K|ENST00000310463,p.E312K	retained_intron, protein_coding, nonsense_mediated_decay	uc010yzw.2	nonsynonymous SNV	exon5	c.G1240A	p.E414K	LEGSQRPQAVPEEASFPRDQEATHF	LEGSQRPQAVPEKASFPRDQEATHF	6.0	7.0	-	-	3795_2:130897612-130897612 C>T_LEGSQRPQAVPEKASFPRDQEATHF	0.0
8:141460944-141460944 G>A	1.0	3713	MELANOMA	-	-	-	-	TRAPPC9	ENST00000389328,p.L275F|NM_001160372,p.L177F|uc003yvh.2,p.L275F|ENST00000389327,p.L177F|uc003yvj.2,p.L177F|uc003yvi.1,p.L177F|NM_031466,p.L275F|ENST00000438773,p.L177F	retained_intron, protein_coding, processed_transcript	uc003yvj.2	nonsynonymous SNV	exon2	c.C529T	p.L177F	DRATDKSGDKIPLLCVPFEKKDFVG	DRATDKSGDKIPFLCVPFEKKDFVG	3.0	10.0	-	-	3713_8:141460944-141460944 G>A_DRATDKSGDKIPFLCVPFEKKDFVG	0.0
10:1405554-1405554 G>A	0.0	4326	BREAST	-	-	-	-	ADARB2	uc009xhq.3,p.A249V|ENST00000381312,p.A249V|NM_018702,p.A249V	protein_coding, processed_transcript	uc009xhq.3	nonsynonymous SNV	exon3	c.C746T	p.A249V	AGGRPGDAALLSAAYGRRRLLCRAL	AGGRPGDAALLSVAYGRRRLLCRAL	3.0	2.0	-	-	4326_10:1405554-1405554 G>A_AGGRPGDAALLSVAYGRRRLLCRAL	0.0
18:6171859-6171859 T>C	0.0	4078	GASTRIC	-	-	-	-	L3MBTL4	uc002kmy.4,p.D355G|uc002kmz.4,p.D355G|ENST00000535782,p.D168G|NM_173464,p.D355G|uc010dkt.3,p.D355G|ENST00000317931,p.D355G|ENST00000400105,p.D355G|ENST00000400104,p.D355G|ENST00000284898,p.D355G	protein_coding, processed_transcript	uc010dkt.3	nonsynonymous SNV	exon13	c.A1064G	p.D355G	ADSPDIHPIGWCDVTGHPLEVPQRT	ADSPDIHPIGWCGVTGHPLEVPQRT	4.0	3.0	-	-	4078_18:6171859-6171859 T>C_ADSPDIHPIGWCGVTGHPLEVPQRT	0.0
2:27803644-27803644 C>T	0.0	2591	MELANOMA	-	-	-	-	C2orf16	ENST00000408964,p.P1402L|uc002rkz.4,p.P1402L|NM_032266,p.P1402L	protein_coding	uc002rkz.4	nonsynonymous SNV	exon1	c.C4205T	p.P1402L	YYPKQNARDYCLPSSIKRDKRSADK	YYPKQNARDYCLLSSIKRDKRSADK	3.0	2.0	-	-	2591_2:27803644-27803644 C>T_YYPKQNARDYCLLSSIKRDKRSADK	0.0
12:101381399-101381399 G>A	1.0	2556	MELANOMA	-	-	-	-	ANO4	ENST00000392979,p.E194K|uc010svm.1,p.E229K|uc001thx.2,p.E229K|NM_178826,p.E194K|ENST00000392977,p.E229K|NM_001286616,p.E229K|NM_001286615,p.E229K|uc001thw.2,p.E194K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010svm.1	nonsynonymous SNV	exon8	c.G685A	p.E229K	PMRLDKETLPDLEENDCYTAPFSQQ	PMRLDKETLPDLKENDCYTAPFSQQ	6.0	10.0	-	-	2556_12:101381399-101381399 G>A_PMRLDKETLPDLKENDCYTAPFSQQ	0.0
8:73848924-73848924 G>C	0.0	4126	NSCLC	-	-	-	-	KCNB2	NM_004770,p.R445T|uc003xzb.3,p.R445T|ENST00000523207,p.R445T	protein_coding	uc003xzb.3	nonsynonymous SNV	exon3	c.G1334C	p.R445T	AIKRREALERAKRNGSIVSMNLKDA	AIKRREALERAKTNGSIVSMNLKDA	1.0	6.0	-	-	4126_8:73848924-73848924 G>C_AIKRREALERAKTNGSIVSMNLKDA	0.0
15:44127283-44127283 G>A	1.0	4180	BREAST	-	-	ID=COSM3794191;OCCURENCE=1(urinary_tract)	-	WDR76	uc021skg.1,p.E99K|NM_001167941,p.E99K|uc001zti.2,p.E163K|ENST00000452115,p.E99K|ENST00000263795,p.E163K|NM_024908,p.E163K|ENST00000381246,p.E99K	protein_coding, processed_transcript	uc021skg.1	nonsynonymous SNV	exon3	c.G295A	p.E99K	TPSLDFSGLSPYERKRLKNISENAD	TPSLDFSGLSPYKRKRLKNISENAD	9.0	7.0	-	-	4180_15:44127283-44127283 G>A_TPSLDFSGLSPYKRKRLKNISENAD	0.0
15:83735582-83735582 A>T	1.0	4252	COLORECTAL	-	-	-	-	BTBD1	NM_025238,p.F108I|uc002bjo.3,p.F108I|ENST00000261721,p.F108I|ENST00000379403,p.F108I|NM_001011885,p.F108I|uc002bjn.3,p.F108I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002bjo.3	nonsynonymous SNV	exon1	c.T322A	p.F108I	VLAAGSAVFDAMFNGGMATTSAEIE	VLAAGSAVFDAMINGGMATTSAEIE	9.0	4.0	-	-	4252_15:83735582-83735582 A>T_VLAAGSAVFDAMINGGMATTSAEIE	0.0
1:53320240-53320240 C>T	0.0	4237	NSCLC	-	-	ID=COSM1343410;OCCURENCE=1(large_intestine),1(pancreas)	-	ZYG11A	NM_001004339,p.P65L|ENST00000371528,p.P65L|uc001cuk.2,p.P65L	protein_coding	uc001cuk.2	nonsynonymous SNV	exon2	c.C194T	p.P65L	LCSERPDGTLCLPEHWSFPQEVAER	LCSERPDGTLCLLEHWSFPQEVAER	4.0	10.0	-	-	4237_1:53320240-53320240 C>T_LCSERPDGTLCLLEHWSFPQEVAER	0.0
19:51022018-51022018 C>T	0.0	4281	COLORECTAL	-	-	-	-	LRRC4B	uc002pss.3,p.D318N|ENST00000599957,p.D318N|NM_001080457,p.D318N|ENST00000389201,p.D318N	protein_coding	uc002pss.3	nonsynonymous SNV	exon3	c.G952A	p.D318N	VHLNHNPWHCNCDVLWLSWWLKETV	VHLNHNPWHCNCNVLWLSWWLKETV	4.0	3.0	-	-	4281_19:51022018-51022018 C>T_VHLNHNPWHCNCNVLWLSWWLKETV	0.0
19:3449071-3449071 C>T	1.0	3713	MELANOMA	-	-	-	-	NFIC	uc010xhj.2,p.P340S|ENST00000346156,p.P307S|ENST00000443272,p.P340S|NM_001245002,p.P340S|uc010xhi.2,p.P340S|NM_001245004,p.P340S|NM_001245005,p.P331S|uc002lxp.3,p.P340S|ENST00000589123,p.P331S|uc010xhh.2,p.P331S|ENST00000341919,p.P340S|ENST00000586919,p.P307S|NM_205843,p.P331S|NM_005597,p.P340S|ENST00000395111,p.P331S|uc002lxo.3,p.P331S|ENST00000590282,p.P340S	retained_intron, protein_coding, processed_transcript	uc010xhj.2	nonsynonymous SNV	exon7	c.C1018T	p.P340S	TEMDKSPFNSPSPQDSPRLSSFTQH	TEMDKSPFNSPSSQDSPRLSSFTQH	7.0	4.0	-	-	3713_19:3449071-3449071 C>T_TEMDKSPFNSPSSQDSPRLSSFTQH	0.0
17:7287840-7287840 T>C	1.0	4037	NSCLC	-	-	-	-	TNK1	NM_001251902,p.S302P|uc002ggi.4,p.S302P|ENST00000570896,p.S302P|ENST00000311668,p.S302P|uc002ggj.4,p.S302P|NM_003985,p.S302P|ENST00000576812,p.S302P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ggj.4	nonsynonymous SNV	exon7	c.T904C	p.S302P	CAPESLRHGAFSSASDVWMFGVTLW	CAPESLRHGAFSPASDVWMFGVTLW	9.0	3.0	-	-	4037_17:7287840-7287840 T>C_CAPESLRHGAFSPASDVWMFGVTLW	0.0
22:43572326-43572326 T>G	1.0	4180	BREAST	-	-	-	-	TTLL12	NM_015140,p.K306T|ENST00000216129,p.K306T|uc003bdq.3,p.K306T	retained_intron, protein_coding, processed_transcript	uc003bdq.3	nonsynonymous SNV	exon6	c.A917C	p.K306T	INPVVHPHGHIFKVYTDVQQVASSL	INPVVHPHGHIFTVYTDVQQVASSL	10.0	8.0	CD8	-	4180_22:43572326-43572326 T>G_INPVVHPHGHIFTVYTDVQQVASSL	2.0
7:127991332-127991332 C>T	0.0	4213	COLORECTAL	-	-	-	-	PRRT4	uc022akx.1,p.R415Q|ENST00000489835,p.R415Q|NM_001114726,p.R415Q	protein_coding	uc022akx.1	nonsynonymous SNV	exon6	c.G1244A	p.R415Q	PGPCLRGRSAWARTLPHRLAGDRGQ	PGPCLRGRSAWAQTLPHRLAGDRGQ	2.0	9.0	-	-	4213_7:127991332-127991332 C>T_PGPCLRGRSAWAQTLPHRLAGDRGQ	0.0
15:81274493-81274493 G>A	1.0	4189	MELANOMA	-	-	-	-	MESDC2	ENST00000261758,p.P82S|NM_015154,p.P82S|uc002bfy.1,p.P82S|ENST00000561312,p.P82S	protein_coding, processed_transcript, nonsense_mediated_decay	uc002bfy.1	nonsynonymous SNV	exon2	c.C244T	p.P82S	WEKDDDIEEGDLPEHKRPSAPVDFS	WEKDDDIEEGDLSEHKRPSAPVDFS	9.0	9.0	-	-	4189_15:81274493-81274493 G>A_WEKDDDIEEGDLSEHKRPSAPVDFS	0.0
17:57057488-57057488 A>C	1.0	4000	MELANOMA	-	-	-	-	PPM1E	NM_014906,p.K455T|uc010ddd.4,p.K218T|ENST00000308249,p.K455T|uc002iwx.4,p.K455T	protein_coding	uc010ddd.4	nonsynonymous SNV	exon6	c.A653C	p.K218T	PDEAVKVVSDHLKENNGDSSMVAHK	PDEAVKVVSDHLTENNGDSSMVAHK	5.0	9.0	-	-	4000_17:57057488-57057488 A>C_PDEAVKVVSDHLTENNGDSSMVAHK	0.0
3:152554160-152554160 A>T	0.0	4186	BREAST	-	-	-	-	P2RY1	uc003ezq.3,p.N197Y|ENST00000305097,p.N197Y|NM_002563,p.N197Y	protein_coding	uc003ezq.3	nonsynonymous SNV	exon1	c.A589T	p.N197Y	PILFYSGTGVRKNKTITCYDTTSDE	PILFYSGTGVRKYKTITCYDTTSDE	1.0	7.0	-	-	4186_3:152554160-152554160 A>T_PILFYSGTGVRKYKTITCYDTTSDE	0.0
16:70884548-70884548 C>T	0.0	3903	MELANOMA	-	-	-	-	HYDIN	uc031qwy.1,p.D4152N|NM_001270974,p.D4152N|ENST00000393567,p.D4152N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qwy.1	nonsynonymous SNV	exon74	c.G12454A	p.D4152N	EGWIPPLSRFPIDIFFTPKQEGDVN	EGWIPPLSRFPINIFFTPKQEGDVN	3.0	6.0	-	-	3903_16:70884548-70884548 C>T_EGWIPPLSRFPINIFFTPKQEGDVN	0.0
6:26184238-26184238 A>T	1.0	4077	BILE DUCT	-	-	-	-	HIST1H2BE	ENST00000356530,p.E72V|uc003ngt.3,p.E72V|NM_003523,p.E72V	protein_coding	uc003ngt.3	nonsynonymous SNV	exon1	c.A215T	p.E72V	MGIMNSFVNDIFERIAGEASRLAHY	MGIMNSFVNDIFVRIAGEASRLAHY	10.0	10.0	CD8	-	4077_6:26184238-26184238 A>T_MGIMNSFVNDIFVRIAGEASRLAHY	1.0
5:39119092-39119092 G>A	1.0	2369	MELANOMA	-	-	-	-	FYB	ENST00000540520,p.S772F|uc003jlt.3,p.S762F|uc011cpl.2,p.S772F|ENST00000351578,p.S716F|uc003jls.3,p.S716F|NM_001465,p.S762F|ENST00000512982,p.S762F|uc003jlu.3,p.S716F|NM_001243093,p.S772F|ENST00000505428,p.S762F|NM_199335,p.S716F|ENST00000515010,p.S716F	protein_coding, processed_transcript	uc011cpl.2	nonsynonymous SNV	exon16	c.C2315T	p.S772F	EIRVLYSTKVTTSITSKKWGTRDLQ	EIRVLYSTKVTTFITSKKWGTRDLQ	9.0	8.0	-	-	2369_5:39119092-39119092 G>A_EIRVLYSTKVTTFITSKKWGTRDLQ	0.0
6:34392907-34392907 T>G	1.0	4320	COLORECTAL	-	-	-	-	RPS10,RPS10-NUDT3	NM_001014,p.K31T|NM_001203245,p.K31T|ENST00000344700,p.K31T|uc003ojm.3,p.K31T|ENST00000326199,p.K31T|NM_001202470,p.K31T|ENST00000605528,p.K31T|uc021yyu.1,p.K31T|NM_001204091,p.K31T|uc021yyt.1,p.K31T|uc003ojn.3,p.K31T	protein_coding, processed_transcript	uc021yyu.1	nonsynonymous SNV	exon2	c.A92C	p.K31T	GVMVAKKDVHMPKHPELADKNVPNL	GVMVAKKDVHMPTHPELADKNVPNL	10.0	8.0	-	-	4320_6:34392907-34392907 T>G_GVMVAKKDVHMPTHPELADKNVPNL	0.0
1:37948442-37948442 T>C	0.0	4345	COLORECTAL	-	-	ID=COSM908991;OCCURENCE=1(endometrium)	-	ZC3H12A	uc001cbc.1,p.S139P|NM_025079,p.S344P|ENST00000373087,p.S344P|uc001cbb.4,p.S344P	protein_coding, processed_transcript	uc001cbc.1	nonsynonymous SNV	exon3	c.T415C	p.S139P	SVADELRANALLSPPRAPSKDKNGR	SVADELRANALLPPPRAPSKDKNGR	6.0	1.0	-	-	4345_1:37948442-37948442 T>C_SVADELRANALLPPPRAPSKDKNGR	0.0
10:73551035-73551035 C>T	0.0	4235	COLORECTAL	-	-	-	-	CDH23	ENST00000224721,p.R2071W|NM_022124,p.R2066W	protein_coding, processed_transcript	NM_022124	nonsynonymous SNV	exon45	c.C6196T	p.R2066W	HLLITILDDNDNRPTFSPATLTVHL	HLLITILDDNDNWPTFSPATLTVHL	5.0	4.0	-	-	4235_10:73551035-73551035 C>T_HLLITILDDNDNWPTFSPATLTVHL	0.0
18:57105368-57105368 C>T	1.0	3713	MELANOMA	-	-	-	-	CCBE1	uc002lib.3,p.G321E|ENST00000439986,p.G321E|NM_133459,p.G321E|uc010dpq.3,p.G50E|uc002lia.3,p.G174E|ENST00000398179,p.G50E	retained_intron, protein_coding	uc010dpq.3	nonsynonymous SNV	exon4	c.G149A	p.G50E	GAPGRDGSKGERGAPGPRGSPGPPG	GAPGRDGSKGEREAPGPRGSPGPPG	2.0	9.0	-	-	3713_18:57105368-57105368 C>T_GAPGRDGSKGEREAPGPRGSPGPPG	0.0
2:198285224-198285224 G>A	1.0	3466	MELANOMA	-	-	-	1	SF3B1	uc002uuf.3,p.R115W|uc002uue.3,p.R115W|NM_001005526,p.R115W|uc002uug.3,p.R115W|ENST00000487698,p.R115W|ENST00000335508,p.R115W|ENST00000414963,p.R115W|ENST00000409915,p.R115W|NM_012433,p.R115W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uug.3	nonsynonymous SNV	exon4	c.C343T	p.R115W	PFAEHRPPKIADREDEYKKHRRTMI	PFAEHRPPKIADWEDEYKKHRRTMI	10.0	2.0	-	-	3466_2:198285224-198285224 G>A_PFAEHRPPKIADWEDEYKKHRRTMI	0.0
9:114304822-114304822 C>T	0.0	4158	COLORECTAL	-	-	-	-	ZNF483	ENST00000309235,p.S536L|NM_133464,p.S536L|uc004bff.2,p.S536L	protein_coding	uc004bff.2	nonsynonymous SNV	exon6	c.C1607T	p.S536L	KCKDCGRPFSDSSSLIQHQRIHTGE	KCKDCGRPFSDSLSLIQHQRIHTGE	7.0	8.0	-	-	4158_9:114304822-114304822 C>T_KCKDCGRPFSDSLSLIQHQRIHTGE	0.0
5:6753065-6753065 C>T	1.0	3466	MELANOMA	-	-	-	-	PAPD7	uc010itl.1,p.S270F|uc011cmn.2,p.S450F|ENST00000230859,p.S450F|uc003jdx.1,p.S450F|NM_001171806,p.S270F|NM_001171805,p.S450F|NM_006999,p.S450F	retained_intron, protein_coding	uc011cmn.2	nonsynonymous SNV	exon12	c.C1349T	p.S450F	VPCRQAGVEGTASLKAVHHMSSPAI	VPCRQAGVEGTAFLKAVHHMSSPAI	9.0	7.0	-	-	3466_5:6753065-6753065 C>T_VPCRQAGVEGTAFLKAVHHMSSPAI	0.0
18:76755310-76755310 C>T	1.0	4284	COLORECTAL	-	-	-	-	SALL3	ENST00000536229,p.R902C|ENST00000575389,p.R1035C|uc002lmt.3,p.R1107C|NM_171999,p.R1107C|ENST00000537592,p.R1107C|uc010dra.3,p.R642C	protein_coding, processed_transcript	uc010dra.3	nonsynonymous SNV	exon2	c.C1924T	p.R642C	GPGLAPMLAPPPRRTPKQHNCQSCG	GPGLAPMLAPPPCRTPKQHNCQSCG	6.0	9.0	-	-	4284_18:76755310-76755310 C>T_GPGLAPMLAPPPCRTPKQHNCQSCG	0.0
4:25834625-25834625 C>T	1.0	4213	COLORECTAL	-	-	-	-	SEL1L3	NM_001297592,p.G329R|NM_015187,p.G364R|NM_001297594,p.G211R|uc003gru.4,p.G364R|ENST00000399878,p.G364R|ENST00000264868,p.G329R|ENST00000502949,p.G211R	retained_intron, protein_coding, processed_transcript	uc003gru.4	nonsynonymous SNV	exon5	c.G1090A	p.G364R	LKEWFRLDISFNGGQIVVTTSIGQD	LKEWFRLDISFNRGQIVVTTSIGQD	10.0	8.0	-	-	4213_4:25834625-25834625 C>T_LKEWFRLDISFNRGQIVVTTSIGQD	0.0
5:70858183-70858183 A>T	1.0	4320	COLORECTAL	-	-	-	-	BDP1	uc003kbp.1,p.S2527C|ENST00000525844,p.S549C|NM_018429,p.S2527C|ENST00000358731,p.S2527C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003kbp.1	nonsynonymous SNV	exon38	c.A7579T	p.S2527C	NSLESDEPMQVHSKKRLKPLIPGLR	NSLESDEPMQVHCKKRLKPLIPGLR	8.0	8.0	-	-	4320_5:70858183-70858183 A>T_NSLESDEPMQVHCKKRLKPLIPGLR	0.0
19:44792165-44792165 G>A	1.0	3879	MELANOMA	-	-	-	-	ZNF235	uc002ozb.4,p.H471Y|NM_004234,p.H475Y|ENST00000291182,p.H475Y|uc002oza.4,p.H475Y	retained_intron, protein_coding, nonsense_mediated_decay	uc002ozb.4	nonsynonymous SNV	exon5	c.C1411T	p.H471Y	ECGKCFSLSFNLHSHQRVHTGEKPY	ECGKCFSLSFNLYSHQRVHTGEKPY	5.0	8.0	-	-	3879_19:44792165-44792165 G>A_ECGKCFSLSFNLYSHQRVHTGEKPY	0.0
11:66639309-66639309 G>A	1.0	4326	BREAST	-	-	-	-	PC	NM_001040716,p.T57M|NM_022172,p.T57M|uc001ojn.1,p.T57M|NM_000920,p.T57M|ENST00000393958,p.T57M|ENST00000524491,p.T17M|ENST00000393955,p.T57M|ENST00000355677,p.T57M|uc001ojo.1,p.T57M|ENST00000393960,p.T57M|uc001ojp.1,p.T57M	protein_coding, processed_transcript	uc001ojp.1	nonsynonymous SNV	exon4	c.C170T	p.T57M	RGEIAIRVFRACTELGIRTVAIYSE	RGEIAIRVFRACMELGIRTVAIYSE	6.0	4.0	-	-	4326_11:66639309-66639309 G>A_RGEIAIRVFRACMELGIRTVAIYSE	0.0
3:41275240-41275240 G>A	1.0	4245	COLORECTAL	-	-	ID=COSM1582585;OCCURENCE=1(stomach),1(large_intestine)	1	CTNNB1	uc011azf.1,p.R462H|ENST00000396183,p.R469H|uc003ckr.2,p.R469H|uc011azg.1,p.R397H|NM_001098209,p.R469H|ENST00000396185,p.R469H|ENST00000349496,p.R469H|ENST00000405570,p.R469H|uc003cks.3,p.R72H|uc003ckq.2,p.R469H|ENST00000453024,p.R462H|NM_001904,p.R469H|uc003ckp.2,p.R469H|uc010hia.1,p.R469H|NM_001098210,p.R469H	retained_intron, protein_coding, processed_transcript	uc011azg.1	nonsynonymous SNV	exon9	c.G1190A	p.R397H	REDITEPAICALRHLTSRHQEAEMA	REDITEPAICALHHLTSRHQEAEMA	10.0	8.0	-	-	4245_3:41275240-41275240 G>A_REDITEPAICALHHLTSRHQEAEMA	0.0
1:156236042-156236042 C>T	1.0	3775	CERVICAL	0.0005	-	-	-	SMG5	uc001foc.4,p.R462H|NM_015327,p.R462H|ENST00000361813,p.R462H	protein_coding, processed_transcript	uc001foc.4	nonsynonymous SNV	exon12	c.G1385A	p.R462H	SRKFSRLSCLRRRRHPPKVGDDSDL	SRKFSRLSCLRRHRHPPKVGDDSDL	9.0	8.0	-	-	3775_1:156236042-156236042 C>T_SRKFSRLSCLRRHRHPPKVGDDSDL	0.0
10:129914758-129914758 G>A	1.0	3713	MELANOMA	-	-	-	-	MKI67	ENST00000368654,p.P133S|uc001lke.3,p.P133S|NM_002417,p.P133S	protein_coding, processed_transcript	uc001lke.3	nonsynonymous SNV	exon6	c.C397T	p.P133S	ARRVSRSSFSSDPDEKAQDSKAYSK	ARRVSRSSFSSDSDEKAQDSKAYSK	5.0	6.0	-	-	3713_10:129914758-129914758 G>A_ARRVSRSSFSSDSDEKAQDSKAYSK	0.0
1:110593647-110593647 A>T	1.0	3466	MELANOMA	-	-	-	-	STRIP1	uc009wfp.2,p.N500Y|NM_033088,p.N676Y|ENST00000369796,p.N581Y|uc001dza.2,p.N676Y|ENST00000369795,p.N676Y|uc001dyz.1,p.N581Y|NM_001270768,p.N581Y	retained_intron, protein_coding, processed_transcript	uc009wfp.2	nonsynonymous SNV	exon20	c.A1498T	p.N500Y	NLFSCINLLRILNKLTKWKHSRTMM	NLFSCINLLRILYKLTKWKHSRTMM	8.0	3.0	-	-	3466_1:110593647-110593647 A>T_NLFSCINLLRILYKLTKWKHSRTMM	0.0
17:43922298-43922298 C>T	0.0	3713	MELANOMA	-	-	-	-	SPPL2C	uc010wka.2,p.P9L|NM_175882,p.P9L|ENST00000329196,p.P9L	protein_coding	uc010wka.2	nonsynonymous SNV	exon1	c.C26T	p.P9L	MACLGFLLPVGFLLLISTVAG	MACLGFLLLVGFLLLISTVAG	1.0	6.0	-	-	3713_17:43922298-43922298 C>T_MACLGFLLLVGFLLLISTVAG	0.0
17:42992432-42992432 C>A	0.0	4284	COLORECTAL	-	-	-	-	GFAP	uc021tyh.1,p.R141S|uc002ihr.3,p.R141S|NM_002055,p.R141S|ENST00000588316,p.R141S|ENST00000588037,p.R141S|ENST00000435360,p.R141S|ENST00000592320,p.R141S|ENST00000253408,p.R141S|ENST00000586793,p.R141S|uc002ihq.3,p.R141S|ENST00000376990,p.R141S|NM_001242376,p.R141S|NM_001131019,p.R141S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tyh.1	nonsynonymous SNV	exon1	c.G423T	p.R141S	QLTANSARLEVERDNLAQDLATVRQ	QLTANSARLEVESDNLAQDLATVRQ	3.0	6.0	-	-	4284_17:42992432-42992432 C>A_QLTANSARLEVESDNLAQDLATVRQ	0.0
12:70963625-70963625 G>A	0.0	2591	MELANOMA	-	-	-	1	PTPRB	uc001swa.4,p.S1067F|ENST00000261266,p.S937F|ENST00000451516,p.S847F|uc001swb.4,p.S937F|NM_002837,p.S937F|NM_001109754,p.S1155F|NM_001206971,p.S847F|uc001swc.4,p.S1155F|ENST00000551525,p.S1154F|ENST00000550857,p.S847F|ENST00000548122,p.S1034F|ENST00000538708,p.S937F|ENST00000334414,p.S1155F|uc010stp.2,p.S847F|ENST00000550358,p.S1067F|uc010sto.2,p.S937F|NM_001206972,p.S937F|uc009zrr.2,p.S1034F|uc001swd.4,p.S1154F	retained_intron, protein_coding, processed_transcript	uc010stp.2	nonsynonymous SNV	exon11	c.C2540T	p.S847F	TVNWTPGGGDVDSYTVSAFRHSQKV	TVNWTPGGGDVDFYTVSAFRHSQKV	4.0	7.0	-	-	2591_12:70963625-70963625 G>A_TVNWTPGGGDVDFYTVSAFRHSQKV	0.0
17:79095107-79095107 C>A	1.0	4129	NSCLC	-	-	-	-	AATK	NM_004920,p.D774Y|ENST00000326724,p.D877Y|ENST00000374792,p.D841Y|ENST00000417379,p.D774Y|NM_001080395,p.D877Y|uc010dia.3,p.D877Y|ENST00000570932,p.D67Y|uc021ueu.1,p.D774Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ueu.1	nonsynonymous SNV	exon10	c.G2320T	p.D774Y	EATSGIFTDTSSDGLQARRPDVVPA	EATSGIFTDTSSYGLQARRPDVVPA	6.0	4.0	-	-	4129_17:79095107-79095107 C>A_EATSGIFTDTSSYGLQARRPDVVPA	0.0
3:130377562-130377562 G>T	0.0	3795	MELANOMA	-	-	-	-	COL6A6	uc010htl.3,p.G1926W|NM_001102608,p.G1926W|ENST00000453409,p.G1926W|ENST00000358511,p.G1926W|uc003eni.4,p.G25W	protein_coding, nonsense_mediated_decay	uc010htl.3	nonsynonymous SNV	exon33	c.G5776T	p.G1926W	DTGTFQVIVVPSGADYIPALERLQR	DTGTFQVIVVPSWADYIPALERLQR	1.0	8.0	-	-	3795_3:130377562-130377562 G>T_DTGTFQVIVVPSWADYIPALERLQR	0.0
9:131860571-131860571 G>A	1.0	3713	MELANOMA	-	-	-	-	CRAT	NM_001257363,p.P408S|uc004bxk.4,p.P408S|uc004bxh.3,p.P429S|ENST00000318080,p.P429S|NM_000755,p.P429S	protein_coding, processed_transcript, nonsense_mediated_decay	uc004bxk.4	nonsynonymous SNV	exon11	c.C1222T	p.P408S	FGKDFPKSEKLSPDAFIQMALQLAY	FGKDFPKSEKLSSDAFIQMALQLAY	5.0	9.0	-	-	3713_9:131860571-131860571 G>A_FGKDFPKSEKLSSDAFIQMALQLAY	0.0
2:238664814-238664814 G>T	1.0	4284	COLORECTAL	-	-	-	-	LRRFIP1	ENST00000392000,p.R244I|uc002vxf.3,p.R188I|ENST00000244815,p.R220I|uc010znm.2,p.R188I|uc002vxe.3,p.R244I|ENST00000289175,p.R188I|NM_004735,p.R220I|NM_001137553,p.R188I|uc002vxd.3,p.R220I|NM_001137551,p.R188I|NM_001137552,p.R244I	retained_intron, protein_coding, processed_transcript	uc010znm.2	nonsynonymous SNV	exon6	c.G563T	p.R188I	FQFAEVKEALKQREEMLEKHGIILN	FQFAEVKEALKQIEEMLEKHGIILN	10.0	10.0	-	-	4284_2:238664814-238664814 G>T_FQFAEVKEALKQIEEMLEKHGIILN	0.0
20:61460980-61460980 G>A	1.0	3466	MELANOMA	-	-	-	-	COL9A3	ENST00000343916,p.G352S|NM_001853,p.G352S|uc002ydm.3,p.G352S	retained_intron, protein_coding, processed_transcript	uc002ydm.3	nonsynonymous SNV	exon21	c.G1054A	p.G352S	GRAGSKGEKGERGRAGELGEAGPSG	GRAGSKGEKGERSRAGELGEAGPSG	10.0	4.0	-	-	3466_20:61460980-61460980 G>A_GRAGSKGEKGERSRAGELGEAGPSG	0.0
1:62739601-62739601 G>T	0.0	4110	BILE DUCT	-	-	-	-	KANK4	uc001dah.4,p.A392D|ENST00000371153,p.A392D|NM_181712,p.A392D	protein_coding	uc001dah.4	nonsynonymous SNV	exon3	c.C1175A	p.A392D	REQRIRELEFTVAQLEGQFHQENAK	REQRIRELEFTVDQLEGQFHQENAK	3.0	5.0	-	-	4110_1:62739601-62739601 G>T_REQRIRELEFTVDQLEGQFHQENAK	0.0
X:114425733-114425733 G>A	0.0	3998	MELANOMA	-	-	ID=COSM1113485;OCCURENCE=1(endometrium)	-	RBMXL3	uc011mte.1,p.D577N|ENST00000424776,p.D577N|NM_001145346,p.D577N	protein_coding	uc011mte.1	nonsynonymous SNV	exon1	c.G1729A	p.D577N	GGCSADAYSGGHDSSSQSNRYGGGG	GGCSADAYSGGHNSSSQSNRYGGGG	1.0	10.0	-	-	3998_X:114425733-114425733 G>A_GGCSADAYSGGHNSSSQSNRYGGGG	0.0
18:56940363-56940363 C>T	0.0	4196	COLORECTAL	-	-	-	-	RAX	uc010dpp.3,p.G17S|ENST00000256852,p.G26S|ENST00000555288,p.G26S|ENST00000334889,p.G26S|NM_013435,p.G26S|uc002lhx.3,p.G26S	retained_intron, protein_coding	uc010dpp.3	nonsynonymous SNV	exon1	c.G49A	p.G17S	SFSLAGHLLRSPGGSTSRLHSIEAI	SFSLAGHLLRSPSGSTSRLHSIEAI	4.0	10.0	-	-	4196_18:56940363-56940363 C>T_SFSLAGHLLRSPSGSTSRLHSIEAI	0.0
8:27255130-27255130 G>A	1.0	4320	COLORECTAL	0.0014	-	-	-	PTK2B	NM_173175,p.R10Q|ENST00000412793,p.R10Q|uc003xfq.2,p.R10Q|ENST00000420218,p.R10Q|uc003xfp.2,p.R10Q|uc003xfn.2,p.R10Q|NM_004103,p.R10Q|ENST00000522338,p.R10Q|NM_173174,p.R10Q|ENST00000397501,p.R10Q|ENST00000346049,p.R10Q|uc022ate.1,p.R10Q|NM_173176,p.R10Q|ENST00000544172,p.R10Q|ENST00000517339,p.R10Q|ENST00000522517,p.R10Q|ENST00000338238,p.R10Q|ENST00000521164,p.R10Q	retained_intron, protein_coding, processed_transcript	uc022ate.1	nonsynonymous SNV	exon3	c.G29A	p.R10Q	MSGVSEPLSRVKLGTLRRPEGP	MSGVSEPLSQVKLGTLRRPEGP	8.0	8.0	-	-	4320_8:27255130-27255130 G>A_MSGVSEPLSQVKLGTLRRPEGP	0.0
7:92764074-92764074 C>T	1.0	3713	MELANOMA	-	-	-	-	SAMD9L	uc003umh.1,p.G404E|ENST00000437805,p.G404E|uc022ahh.1,p.G404E|NM_152703,p.G404E|uc010lfb.1,p.G404E|uc003umj.1,p.G404E|uc010lfd.1,p.G404E|uc003umk.1,p.G404E|uc003umi.1,p.G404E|ENST00000318238,p.G404E|ENST00000411955,p.G404E|uc010lfc.1,p.G404E	protein_coding, processed_transcript	uc022ahh.1	nonsynonymous SNV	exon1	c.G1211A	p.G404E	ESEGLKLVKLLIGNRDSLDNSYYDW	ESEGLKLVKLLIENRDSLDNSYYDW	9.0	8.0	-	-	3713_7:92764074-92764074 C>T_ESEGLKLVKLLIENRDSLDNSYYDW	0.0
13:115090093-115090093 C>A	1.0	4258	ENDOMETRIAL	-	-	-	-	CHAMP1	uc001vuv.3,p.P259Q|ENST00000361283,p.P259Q|NM_001164145,p.P259Q|uc010tko.2,p.P259Q|NM_032436,p.P259Q|uc021rmx.1,p.P259Q|uc010ahb.3,p.P259Q|NM_001164144,p.P259Q	protein_coding, processed_transcript	uc021rmx.1	nonsynonymous SNV	exon1	c.C776A	p.P259Q	SPVLAASPEPWGPSPAASPESRKSA	SPVLAASPEPWGQSPAASPESRKSA	7.0	7.0	-	-	4258_13:115090093-115090093 C>A_SPVLAASPEPWGQSPAASPESRKSA	0.0
14:32563354-32563354 T>C	1.0	4000	MELANOMA	-	-	-	2	ARHGAP5	NM_001173,p.L1160S|uc001wrm.3,p.L1160S|ENST00000539826,p.L1160S|ENST00000432921,p.L1160S|ENST00000345122,p.L1160S|ENST00000556611,p.L1160S|uc001wrl.3,p.L1160S|NM_001030055,p.L1160S|uc001wrn.3,p.L1160S	retained_intron, protein_coding, nonsense_mediated_decay	uc001wrn.3	nonsynonymous SNV	exon2	c.T3479C	p.L1160S	RRPSKYKYKSKTLFSKAKSYYRRTH	RRPSKYKYKSKTSFSKAKSYYRRTH	10.0	9.0	-	-	4000_14:32563354-32563354 T>C_RRPSKYKYKSKTSFSKAKSYYRRTH	0.0
7:78636418-78636418 G>A	0.0	4095	COLORECTAL	-	-	ID=COSM1257168;OCCURENCE=1(oesophagus)	-	MAGI2	NM_001301128,p.R136C|ENST00000522391,p.R136C|NM_012301,p.R136C|uc003ugy.3,p.R136C|ENST00000354212,p.R136C|uc003ugx.3,p.R136C|ENST00000419488,p.R136C	retained_intron, protein_coding, processed_transcript	uc003ugy.3	nonsynonymous SNV	exon2	c.C406T	p.R136C	ELQQIIRDNLYLRTVPCTTRPHKEG	ELQQIIRDNLYLCTVPCTTRPHKEG	6.0	8.0	-	-	4095_7:78636418-78636418 G>A_ELQQIIRDNLYLCTVPCTTRPHKEG	0.0
12:6494516-6494516 G>A	1.0	4180	BREAST	-	-	-	-	LTBR	ENST00000543190,p.C41Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000543190	nonsynonymous SNV	exon4	c.G122A	p.C41Y	ALECTHCELLSDCPPGTEAELKGVR	ALECTHCELLSDYPPGTEAELKGVR	10.0	6.0	-	-	4180_12:6494516-6494516 G>A_ALECTHCELLSDYPPGTEAELKGVR	0.0
7:944729-944729 C>G	1.0	4186	BREAST	-	-	-	-	ADAP1	uc003sjn.4,p.E85Q|uc011jvs.2,p.E62Q|ENST00000435943,p.E144Q|uc003sjo.4,p.E157Q|NM_001284308,p.E168Q|ENST00000265846,p.E157Q|uc010ksc.3,p.E85Q|NM_001284310,p.E85Q|NM_001284309,p.E85Q|NM_006869,p.E157Q|ENST00000539900,p.E168Q|ENST00000449296,p.E85Q|NM_001284311,p.E62Q	retained_intron, protein_coding, processed_transcript	uc011jvs.2	nonsynonymous SNV	exon3	c.G184C	p.E62Q	QFLSRKFVLTEREGALKYFNRNDAK	QFLSRKFVLTERQGALKYFNRNDAK	8.0	7.0	-	-	4186_7:944729-944729 C>G_QFLSRKFVLTERQGALKYFNRNDAK	0.0
17:58571953-58571953 C>G	1.0	3879	MELANOMA	-	-	-	-	APPBP2	uc010ddl.1,p.A14P|NM_001282476,p.A14P	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ddl.1	nonsynonymous SNV	exon2	c.G40C	p.A14P	FTTRHLLHHCFQALMDHGVKVASVL	FTTRHLLHHCFQPLMDHGVKVASVL	8.0	7.0	-	-	3879_17:58571953-58571953 C>G_FTTRHLLHHCFQPLMDHGVKVASVL	0.0
2:105473259-105473259 C>A	0.0	4126	NSCLC	-	-	-	-	POU3F3	uc010ywg.2,p.P431T|ENST00000361360,p.P431T|NM_006236,p.P431T	protein_coding	uc010ywg.2	nonsynonymous SNV	exon1	c.C1291A	p.P431T	GALESHFLKCPKPSAQEITNLADSL	GALESHFLKCPKTSAQEITNLADSL	1.0	8.0	-	-	4126_2:105473259-105473259 C>A_GALESHFLKCPKTSAQEITNLADSL	0.0
17:7577594-7577595 AC>-	1.0	4326	BREAST	-	-	ID=COSM44360,COSM111636,COSM111635,COSM111637;OCCURENCE=3(large_intestine),2(breast),1(oesophagus),3(ovary)	1	TP53	NM_001126117,p.C97fs|uc002gii.2,p.C70fs|NM_001126115,p.C97fs|uc010cng.2,p.C70fs|NM_001126112,p.C229fs|uc002gim.3,p.C229fs|NM_001126116,p.C97fs|ENST00000420246,p.C229fs|NM_001276697,p.C70fs|uc002gij.3,p.C190fs|NM_001126113,p.C229fs|uc002gio.3,p.C97fs|NM_001276761,p.C190fs|NM_001276696,p.C190fs|NM_001126118,p.C190fs|ENST00000514944,p.C136fs|uc002gin.3,p.C136fs|ENST00000445888,p.C229fs|uc031qyq.1,p.C190fs|uc010cni.2,p.C229fs|ENST00000359597,p.C229fs|uc002gih.3,p.C229fs|NM_001126114,p.C229fs|ENST00000509690,p.C97fs|ENST00000269305,p.C229fs|NM_001276760,p.C190fs|NM_000546,p.C229fs|ENST00000455263,p.C229fs|ENST00000413465,p.C229fs|NM_001276699,p.C70fs|uc010cnf.2,p.C70fs|uc010cnh.2,p.C229fs|NM_001276698,p.C70fs|uc002gig.1,p.C229fs|NM_001276695,p.C190fs	retained_intron, protein_coding, processed_transcript	uc031qyq.1	frameshift deletion	exon6	c.569_570del	p.C190fs	VVPYEPPEVGSDCTTIHYNYMCNSSC	VVPYEPPEVGSDYHHPLQLHV	8.0	10.0	-	-	4326_17:7577594-7577595 AC>-_VVPYEPPEVGSDYHHPLQLHV	0.0
7:117067454-117067454 C>T	0.0	4186	BREAST	-	-	ID=COSM598561;OCCURENCE=1(lung)	-	ASZ1	uc003vjb.2,p.E21K|NM_130768,p.E21K|NM_001301821,p.E21K|ENST00000450714,p.E21K|uc011kno.1,p.E21K|ENST00000284629,p.E21K	retained_intron, protein_coding, nonsense_mediated_decay	uc011kno.1	nonsynonymous SNV	exon1	c.G61A	p.E21K	LPVAGGGESSESEDDGWEIGYLDRT	LPVAGGGESSESKDDGWEIGYLDRT	1.0	7.0	-	-	4186_7:117067454-117067454 C>T_LPVAGGGESSESKDDGWEIGYLDRT	0.0
12:6483615-6483615 T>A	1.0	4281	COLORECTAL	-	-	-	-	SCNN1A	NM_001159575,p.Y135F|uc001qnx.3,p.Y112F|ENST00000536788,p.Y133F|ENST00000228916,p.Y112F|ENST00000543768,p.Y135F|uc001qnw.3,p.Y171F|uc010sfb.2,p.Y135F|NM_001159576,p.Y171F|NM_001038,p.Y112F|ENST00000358945,p.Y112F|ENST00000338748,p.Y112F|ENST00000396966,p.Y112F|ENST00000360168,p.Y171F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010sfb.2	nonsynonymous SNV	exon2	c.A404T	p.Y135F	WQFGLLFGEYFSYPVSLNINLNSDK	WQFGLLFGEYFSFPVSLNINLNSDK	10.0	6.0	-	-	4281_12:6483615-6483615 T>A_WQFGLLFGEYFSFPVSLNINLNSDK	0.0
6:33152774-33152774 C>T	1.0	4155	MELANOMA	-	-	-	-	COL11A2	ENST00000395197,p.E312K|uc003ocy.1,p.E286K|ENST00000374708,p.E286K|NM_080681,p.E286K	protein_coding, processed_transcript	uc003ocy.1	nonsynonymous SNV	exon6	c.G856A	p.E286K	EEILESSLLPPLEEAAHGPRGLKGE	EEILESSLLPPLKEAAHGPRGLKGE	5.0	9.0	-	-	4155_6:33152774-33152774 C>T_EEILESSLLPPLKEAAHGPRGLKGE	0.0
3:42251399-42251399 G>C	1.0	4134	NSCLC	-	-	-	-	TRAK1	uc011azi.3,p.E629Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc011azi.3	nonsynonymous SNV	exon14	c.G1885C	p.E629Q	VDLDEVYCLNDFEEDDTAHHPGKCM	VDLDEVYCLNDFQEDDTAHHPGKCM	7.0	9.0	-	-	4134_3:42251399-42251399 G>C_VDLDEVYCLNDFQEDDTAHHPGKCM	0.0
4:72623770-72623770 T>G	0.0	4046	OVARIAN	-	-	-	-	GC	uc021xpb.1,p.M274L|NM_001204307,p.M293L|uc003hge.3,p.M274L|ENST00000509740,p.M274L|NM_000583,p.M274L|uc010iif.3,p.M293L|ENST00000504199,p.M293L|ENST00000273951,p.M274L|NM_001204306,p.M274L|ENST00000513476,p.M274L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xpb.1	nonsynonymous SNV	exon8	c.A820C	p.M274L	LSKCCESASEDCMAKELPEHTVKLC	LSKCCESASEDCLAKELPEHTVKLC	1.0	7.0	-	-	4046_4:72623770-72623770 T>G_LSKCCESASEDCLAKELPEHTVKLC	0.0
17:5037195-5037195 G>A	0.0	4346	COLORECTAL	-	-	-	1	USP6	ENST00000250066,p.R133K|ENST00000574788,p.R133K|NM_004505,p.R133K|ENST00000575709,p.R133K|ENST00000572949,p.R133K|uc002gaw.3,p.R194K|ENST00000332776,p.R133K|uc002gav.1,p.R133K|uc002gau.1,p.R133K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002gaw.3	nonsynonymous SNV	exon8	c.G581A	p.R194K	LKNPGRYQIMKERGKRSSEHIHHID	LKNPGRYQIMKEKGKRSSEHIHHID	2.0	1.0	-	-	4346_17:5037195-5037195 G>A_LKNPGRYQIMKEKGKRSSEHIHHID	0.0
7:21639546-21639546 C>A	0.0	4287	COLORECTAL	-	-	-	-	DNAH11	uc031swp.1,p.Q937K|NM_001277115,p.Q937K|ENST00000409508,p.Q937K|ENST00000328843,p.Q937K	retained_intron, protein_coding, processed_transcript	uc031swp.1	nonsynonymous SNV	exon15	c.C2809A	p.Q937K	HDLDFFLKNTEKQLKPAPFFQAQMI	HDLDFFLKNTEKKLKPAPFFQAQMI	3.0	8.0	-	-	4287_7:21639546-21639546 C>A_HDLDFFLKNTEKKLKPAPFFQAQMI	0.0
5:135508150-135508150 ->TAAACA	1.0	4213	COLORECTAL	-	-	-	-	SMAD5	ENST00000545279,p.P268delinsPKH|uc003lbj.1,p.P268delinsPKH|uc003lbk.1,p.P268delinsPKH|uc003lbl.1,p.P268delinsPKH|ENST00000545620,p.P268delinsPKH	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lbl.1	nonframeshift insertion	exon5	c.803_804insTAAACA	p.P268delinsPKH	SSRDVQPVAYEEPKHWCSIVYYELN	SSRDVQPVAYEEPKHKHWCSIVYYE	9.0	7.0	CD8	-	4213_5:135508150-135508150 ->TAAACA_SSRDVQPVAYEEPKHKHWCSIVYYE	1.0
5:140347349-140347349 T>C	0.0	4326	BREAST	-	-	-	-	PCDHAC2	ENST00000289269,p.I333T|NM_031883,p.I333T|NM_018899,p.I333T|uc003lii.3,p.I333T|uc011dag.2,p.I333T	protein_coding	uc011dag.2	nonsynonymous SNV	exon1	c.T998C	p.I333T	GGLDYEEASSYQIYVQATDRGPVPM	GGLDYEEASSYQTYVQATDRGPVPM	3.0	5.0	-	-	4326_5:140347349-140347349 T>C_GGLDYEEASSYQTYVQATDRGPVPM	0.0
19:54871655-54871655 G>A	1.0	4244	COLORECTAL	-	-	-	-	LAIR1	ENST00000391741,p.R99W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000391741	nonsynonymous SNV	exon4	c.C295T	p.R99W	RIDSKPLEARTPRTQSPAPQLDPRR	RIDSKPLEARTPWTQSPAPQLDPRR	9.0	7.0	-	-	4244_19:54871655-54871655 G>A_RIDSKPLEARTPWTQSPAPQLDPRR	0.0
10:45953739-45953739 G>C	1.0	4240	BREAST	-	-	-	-	MARCH8	ENST00000395771,p.S275C|NM_001002266,p.S275C|NM_145021,p.S275C|uc001jcg.1,p.S144C|uc001jck.1,p.S275C|NM_001282866,p.S557C|uc001jch.2,p.S557C|uc001jci.1,p.S275C|ENST00000453424,p.S557C|ENST00000395769,p.S275C|ENST00000319836,p.S275C|uc001jcj.1,p.S275C	protein_coding, processed_transcript	uc001jck.1	nonsynonymous SNV	exon7	c.C824G	p.S275C	KHGYGICHSDTNSSCCTEPEDTGAE	KHGYGICHSDTNCSCCTEPEDTGAE	7.0	10.0	-	-	4240_10:45953739-45953739 G>C_KHGYGICHSDTNCSCCTEPEDTGAE	0.0
1:25747154-25747154 T>G	0.0	4189	MELANOMA	-	-	-	-	RHCE	ENST00000533771,p.K42Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000533771	nonsynonymous SNV	exon1	c.A124C	p.K42Q	FFTHYDASLEDQKGLVASYQVFGWP	FFTHYDASLEDQQGLVASYQVFGWP	5.0	10.0	-	-	4189_1:25747154-25747154 T>G_FFTHYDASLEDQQGLVASYQVFGWP	0.0
20:57766949-57766949 C>T	0.0	4287	COLORECTAL	-	-	-	-	ZNF831	uc002yan.3,p.A292V|NM_178457,p.A292V|ENST00000371030,p.A292V	protein_coding	uc002yan.3	nonsynonymous SNV	exon1	c.C875T	p.A292V	WDSAPMASPGLPAASTQPWRKLPEQ	WDSAPMASPGLPVASTQPWRKLPEQ	2.0	9.0	-	-	4287_20:57766949-57766949 C>T_WDSAPMASPGLPVASTQPWRKLPEQ	0.0
9:104152997-104152997 T>G	0.0	4081	COLORECTAL	-	-	-	-	MRPL50	NM_019051,p.E76D|uc004bbe.2,p.E76D|uc011lvj.2,p.E76D|ENST00000374865,p.E76D|ENST00000539624,p.E76D	protein_coding	uc011lvj.2	nonsynonymous SNV	exon2	c.A228C	p.E76D	EDLQSRLESYVKEVFGSSLPSNWQD	EDLQSRLESYVKDVFGSSLPSNWQD	3.0	2.0	-	-	4081_9:104152997-104152997 T>G_EDLQSRLESYVKDVFGSSLPSNWQD	0.0
13:102359121-102359121 C>T	1.0	3713	MELANOMA	-	-	-	-	ITGBL1	ENST00000376162,p.S290F|NM_001271755,p.S334F|ENST00000376180,p.S383F|ENST00000545560,p.S242F|uc001vpb.4,p.S383F|uc010agb.4,p.S334F|uc001vpc.5,p.S242F|uc031qnc.1,p.S290F|NM_004791,p.S383F|NM_001271754,p.S242F|NM_001271756,p.S290F	protein_coding, processed_transcript	uc031qnc.1	nonsynonymous SNV	exon8	c.C869T	p.S290F	LDGVVCGGHGTCSCGRCVCERGWFG	LDGVVCGGHGTCFCGRCVCERGWFG	2.0	7.0	-	-	3713_13:102359121-102359121 C>T_LDGVVCGGHGTCFCGRCVCERGWFG	0.0
19:9067641-9067641 G>A	0.0	4240	BREAST	-	-	-	2	MUC16	ENST00000397910,p.S6602F|NM_024690,p.S6602F|uc002mkp.3,p.S6602F	protein_coding, processed_transcript, nonsense_mediated_decay	uc002mkp.3	nonsynonymous SNV	exon3	c.C19805T	p.S6602F	TNIAVTNVGTTTSEKESYSSVPAYS	TNIAVTNVGTTTFEKESYSSVPAYS	3.0	8.0	-	-	4240_19:9067641-9067641 G>A_TNIAVTNVGTTTFEKESYSSVPAYS	0.0
1:62739440-62739440 C>T	0.0	4235	COLORECTAL	-	-	-	-	KANK4	ENST00000371153,p.G446R|NM_181712,p.G446R|uc001dah.4,p.G446R	protein_coding	uc001dah.4	nonsynonymous SNV	exon3	c.G1336A	p.G446R	VNLLGSMESESWGHRGEENGLLWGP	VNLLGSMESESWRHRGEENGLLWGP	2.0	7.0	-	-	4235_1:62739440-62739440 C>T_VNLLGSMESESWRHRGEENGLLWGP	0.0
10:77158775-77158775 G>A	1.0	4189	MELANOMA	-	-	-	-	ZNF503	NM_032772,p.S558L|uc001jxg.3,p.S558L|ENST00000535216,p.S558L|ENST00000372524,p.S558L	protein_coding, processed_transcript	uc001jxg.3	nonsynonymous SNV	exon2	c.C1673T	p.S558L	PGTDKLLSGYPSSSSLASAAAAAMA	PGTDKLLSGYPSLSSLASAAAAAMA	4.0	9.0	-	-	4189_10:77158775-77158775 G>A_PGTDKLLSGYPSLSSLASAAAAAMA	0.0
19:54632507-54632507 C>G	0.0	4320	COLORECTAL	-	-	-	-	PRPF31	ENST00000391755,p.R402G|ENST00000321030,p.R408G|uc002qdh.2,p.R408G|NM_015629,p.R408G|uc021vbi.1,p.R408G	retained_intron, protein_coding, processed_transcript	uc021vbi.1	nonsynonymous SNV	exon13	c.C1222G	p.R408G	LGHLGKSGSGRVRQTQVNEATKARI	LGHLGKSGSGRVGQTQVNEATKARI	10.0	2.0	-	-	4320_19:54632507-54632507 C>G_LGHLGKSGSGRVGQTQVNEATKARI	0.0
19:53741769-53741769 C>T	1.0	2369	MELANOMA	-	-	-	-	ZNF677	ENST00000598513,p.E71K|ENST00000333952,p.E71K|uc002qbg.1,p.E71K|ENST00000594517,p.E71K|uc002qbf.1,p.E71K|NM_182609,p.E71K	retained_intron, protein_coding, processed_transcript	uc002qbg.1	nonsynonymous SNV	exon5	c.G211A	p.E71K	SVGFTSKGLSPKENNKEELYHLVIL	SVGFTSKGLSPKKNNKEELYHLVIL	9.0	4.0	-	-	2369_19:53741769-53741769 C>T_SVGFTSKGLSPKKNNKEELYHLVIL	0.0
6:43745317-43745317 G>T	1.0	4126	NSCLC	-	-	-	-	VEGFA	NM_001171630,p.C77F|NM_001171629,p.C77F|ENST00000372067,p.C257F|NM_001204385,p.C257F|uc003owb.3,p.C77F|ENST00000523950,p.C77F|uc003owf.3,p.C257F|NM_001025370,p.C257F|ENST00000372064,p.C257F|NM_001025369,p.C257F|ENST00000518689,p.C77F|NM_001033756,p.C257F|NM_001171622,p.C257F|NM_001171628,p.C77F|NM_001171623,p.C77F|NM_003376,p.C257F|NM_001025367,p.C257F|ENST00000523873,p.C77F|ENST00000457104,p.C77F|NM_001025368,p.C257F|NM_001171625,p.C77F|ENST00000425836,p.C257F|NM_001025366,p.C257F|NM_001171624,p.C77F|ENST00000520948,p.C77F|ENST00000520265,p.C51F|NM_001171627,p.C77F|ENST00000523125,p.C77F|ENST00000482630,p.C257F|ENST00000417285,p.C257F|ENST00000230480,p.C49F|ENST00000372077,p.C77F|ENST00000518824,p.C77F|NM_001171626,p.C77F|ENST00000413642,p.C257F|NM_001287044,p.C49F|ENST00000372055,p.C257F|NM_001204384,p.C77F|ENST00000324450,p.C257F	retained_intron, protein_coding	uc003owf.3	nonsynonymous SNV	exon3	c.G770T	p.C257F	YPDEIEYIFKPSCVPLMRCGGCCND	YPDEIEYIFKPSFVPLMRCGGCCND	10.0	5.0	-	-	4126_6:43745317-43745317 G>T_YPDEIEYIFKPSFVPLMRCGGCCND	0.0
19:11304464-11304464 A>C	0.0	4245	COLORECTAL	-	-	-	-	KANK2	uc021upe.1,p.S98A|ENST00000586659,p.S98A|ENST00000590685,p.S98A|uc002mqo.4,p.S98A|NM_001136191,p.S98A|ENST00000432929,p.S98A|uc002mqm.3,p.S98A|ENST00000589894,p.S98A|uc002mqq.3,p.S98A|ENST00000355150,p.S98A|ENST00000589359,p.S98A|NM_015493,p.S98A	retained_intron, protein_coding, processed_transcript	uc021upe.1	nonsynonymous SNV	exon3	c.T292G	p.S98A	SLCSNASGDSRHSAYSYCGRGFYPQ	SLCSNASGDSRHAAYSYCGRGFYPQ	9.0	1.0	-	-	4245_19:11304464-11304464 A>C_SLCSNASGDSRHAAYSYCGRGFYPQ	0.0
12:97137828-97137828 C>T	0.0	3795	MELANOMA	-	-	-	-	CDK17,NEDD1	ENST00000524981,p.R981C|uc021rcc.1,p.R955C	-	uc021rcc.1	nonsynonymous SNV	exon22	c.C2863T	p.R955C	EQMLAFGETIEFRSSNTKYANPLQP	EQMLAFGETIEFCSSNTKYANPLQP	1.0	10.0	-	-	3795_12:97137828-97137828 C>T_EQMLAFGETIEFCSSNTKYANPLQP	0.0
X:153607870-153607870 A>-	1.0	4237	NSCLC	-	-	-	-	EMD	uc004fkl.3,p.D9fs|ENST00000369835,p.D9fs|ENST00000428228,p.D9fs|NM_000117,p.D9fs|ENST00000369842,p.D9fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004fkl.3	frameshift deletion	exon1	c.26delA	p.D9fs	MDNYADLSDTELTTLLRRYNIP	MDNYADLSVPS	9.0	3.0	-	-	4237_X:153607870-153607870 A>-_MDNYADLSVPS	0.0
2:213914600-213914600 T>G	0.0	4298	COLORECTAL	-	-	-	-	IKZF2	ENST00000431520,p.E137D|ENST00000457361,p.E137D|ENST00000342002,p.E143D|uc002vej.3,p.E84D|ENST00000434687,p.E137D|NM_016260,p.E137D|ENST00000413091,p.E137D|uc002vem.3,p.E137D	retained_intron, protein_coding, nonsense_mediated_decay	uc002vem.3	nonsynonymous SNV	exon5	c.A411C	p.E137D	NVLMVHKRSHTGERPFHCNQCGASF	NVLMVHKRSHTGDRPFHCNQCGASF	6.0	6.0	-	-	4298_2:213914600-213914600 T>G_NVLMVHKRSHTGDRPFHCNQCGASF	0.0
6:4116148-4116148 T>A	1.0	4266	COLORECTAL	-	-	-	-	ECI2	uc003mwf.3,p.N382I|uc003mwd.3,p.N352I|NM_001166010,p.N352I|uc003mwe.3,p.N229I|ENST00000361538,p.N352I|NM_006117,p.N352I|uc021yku.1,p.N352I|ENST00000465828,p.N352I|uc003mwc.3,p.N210I|ENST00000380118,p.N382I|ENST00000413766,p.N215I|ENST00000380125,p.N352I|NM_206836,p.N382I	retained_intron, protein_coding, nonsense_mediated_decay	uc021yku.1	nonsynonymous SNV	exon10	c.A1055T	p.N352I	VLQGRWLSDECTNAVVNFLSRKSKL	VLQGRWLSDECTIAVVNFLSRKSKL	9.0	8.0	CD8	-	4266_6:4116148-4116148 T>A_VLQGRWLSDECTIAVVNFLSRKSKL	1.0
7:101006396-101006396 C>T	0.0	4240	BREAST	-	-	-	-	COL26A1	ENST00000313669,p.S28L|uc003uyo.1,p.S28L	retained_intron, protein_coding, polymorphic_pseudogene	uc003uyo.1	nonsynonymous SNV	exon1	c.C83T	p.S28L	GSALATGFLYPFSAAALQQHGYPEP	GSALATGFLYPFLAAALQQHGYPEP	2.0	8.0	-	-	4240_7:101006396-101006396 C>T_GSALATGFLYPFLAAALQQHGYPEP	0.0
16:75589767-75589767 C>A	1.0	4252	COLORECTAL	-	-	-	-	TMEM231	NM_001077418,p.A82S|ENST00000258173,p.A82S|NM_001077416,p.A135S|ENST00000562410,p.A82S|ENST00000565067,p.A82S|ENST00000398114,p.A111S|ENST00000570006,p.A82S|uc002fem.4,p.A82S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002fem.4	nonsynonymous SNV	exon2	c.G244T	p.A82S	VALLGPESDGFLAWSTFPAFNRLQG	VALLGPESDGFLSWSTFPAFNRLQG	7.0	10.0	-	-	4252_16:75589767-75589767 C>A_VALLGPESDGFLSWSTFPAFNRLQG	0.0
4:144801564-144801564 C>A	0.0	4259	COLORECTAL	-	-	-	-	GYPE	ENST00000506264,p.G46C	protein_coding, nonsense_mediated_decay	ENST00000506264	nonsynonymous SNV	exon2	c.G136T	p.G46C	SVTKSYISSQTNGCVIGNIICSDKS	SVTKSYISSQTNCCVIGNIICSDKS	2.0	2.0	-	-	4259_4:144801564-144801564 C>A_SVTKSYISSQTNCCVIGNIICSDKS	0.0
7:102724251-102724251 A>T	1.0	4252	COLORECTAL	-	-	-	-	ARMC10	ENST00000428183,p.N123Y|ENST00000425331,p.N88Y|NM_001161010,p.N123Y|uc003vay.2,p.N123Y|uc011kli.2,p.N88Y|ENST00000323716,p.N123Y|uc010lis.2,p.N88Y|NM_001161013,p.N88Y|uc003vbb.2,p.N88Y|NM_031905,p.N123Y|uc003vax.2,p.N88Y|ENST00000454559,p.N88Y|uc003vaw.2,p.N123Y|NM_001161012,p.N88Y|NM_001161011,p.N88Y|ENST00000541300,p.N88Y|ENST00000441711,p.N88Y|ENST00000323735,p.N123Y|NM_001161009,p.N88Y	retained_intron, protein_coding, nonsense_mediated_decay	uc011kli.2	nonsynonymous SNV	exon2	c.A262T	p.N88Y	PVIIERALITLGNNAAFSVNQAIIR	PVIIERALITLGYNAAFSVNQAIIR	9.0	4.0	-	-	4252_7:102724251-102724251 A>T_PVIIERALITLGYNAAFSVNQAIIR	0.0
12:53010017-53010017 C>A	0.0	4287	COLORECTAL	-	-	-	-	KRT73	uc001sas.3,p.G199W|ENST00000305748,p.G199W|NM_175068,p.G199W	retained_intron, protein_coding	uc001sas.3	nonsynonymous SNV	exon2	c.G595T	p.G199W	ISNLRKQLETLSGDRVRLDSELRSV	ISNLRKQLETLSWDRVRLDSELRSV	1.0	10.0	-	-	4287_12:53010017-53010017 C>A_ISNLRKQLETLSWDRVRLDSELRSV	0.0
20:20582422-20582422 G>A	1.0	3879	MELANOMA	-	-	-	-	RALGAPA2	uc010zsg.2,p.P104S|NM_020343,p.P703S|uc002wrz.3,p.P703S|uc002wry.3,p.P318S|ENST00000202677,p.P703S	protein_coding, processed_transcript	uc010zsg.2	nonsynonymous SNV	exon13	c.C310T	p.P104S	VGRSFSLSWRSHPDVTEPMRFRSAT	VGRSFSLSWRSHSDVTEPMRFRSAT	7.0	5.0	-	-	3879_20:20582422-20582422 G>A_VGRSFSLSWRSHSDVTEPMRFRSAT	0.0
1:247473692-247473692 G>A	1.0	3466	MELANOMA	-	-	-	-	ZNF496	ENST00000294753,p.P240S|uc009xgv.3,p.P276S|NM_032752,p.P240S|uc010pyv.1,p.P240S|uc001ico.3,p.P240S|ENST00000366498,p.P276S|ENST00000461277,p.P165S|uc001icq.1,p.P15S	protein_coding, processed_transcript	uc010pyv.1	nonsynonymous SNV	exon4	c.C718T	p.P240S	LCFSEEDWSLLDPAQTGFYGEFIIG	LCFSEEDWSLLDSAQTGFYGEFIIG	7.0	3.0	-	-	3466_1:247473692-247473692 G>A_LCFSEEDWSLLDSAQTGFYGEFIIG	0.0
17:19850794-19850794 G>A	1.0	3713	MELANOMA	-	-	-	-	AKAP10	ENST00000225737,p.T301I|uc010vze.2,p.T222I|uc002gwo.4,p.T301I|uc002gwp.2,p.T279I|uc010cqw.2,p.T279I|NM_007202,p.T301I|ENST00000395536,p.T301I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vze.2	nonsynonymous SNV	exon5	c.C665T	p.T222I	KLMKSIEQDAVNTFTKYISPDAAKP	KLMKSIEQDAVNIFTKYISPDAAKP	5.0	10.0	-	-	3713_17:19850794-19850794 G>A_KLMKSIEQDAVNIFTKYISPDAAKP	0.0
1:47016746-47016746 C>T	0.0	4046	OVARIAN	-	-	-	-	KNCN	ENST00000481882,p.A48T	retained_intron, protein_coding, processed_transcript	ENST00000481882	nonsynonymous SNV	exon1	c.G142A	p.A48T	AAAAMGGVFIGAAVLGLLILAYPFL	AAAAMGGVFIGATVLGLLILAYPFL	3.0	5.0	-	-	4046_1:47016746-47016746 C>T_AAAAMGGVFIGATVLGLLILAYPFL	0.0
19:41627431-41627431 G>A	1.0	4284	COLORECTAL	-	-	-	-	CYP2F1	NM_000774,p.G185S|ENST00000532164,p.G185S|uc010xvv.1,p.G185S|uc002opu.1,p.G185S|ENST00000331105,p.G185S	retained_intron, protein_coding, nonsense_mediated_decay, non_stop_decay	uc010xvv.1	nonsynonymous SNV	exon5	c.G553A	p.G185S	RSVSNIICSVLFGSRFDYDDERLLT	RSVSNIICSVLFSSRFDYDDERLLT	2.0	8.0	-	-	4284_19:41627431-41627431 G>A_RSVSNIICSVLFSSRFDYDDERLLT	0.0
8:42587280-42587280 T>G	0.0	4329	COLORECTAL	-	-	-	-	CHRNB3	uc003xpi.1,p.V277G|ENST00000289957,p.V277G|NM_000749,p.V277G	protein_coding, processed_transcript	uc003xpi.1	nonsynonymous SNV	exon5	c.T830G	p.V277G	LSLSTSVLVSLTVFLLVIEEIIPSS	LSLSTSVLVSLTGFLLVIEEIIPSS	1.0	5.0	-	-	4329_8:42587280-42587280 T>G_LSLSTSVLVSLTGFLLVIEEIIPSS	0.0
2:9728454-9728454 G>A	1.0	4240	BREAST	-	-	-	-	YWHAQ	ENST00000381844,p.T141M|ENST00000238081,p.T141M|NM_006826,p.T141M|uc002qzx.3,p.T141M	protein_coding, processed_transcript	uc002qzx.3	nonsynonymous SNV	exon4	c.C422T	p.T141M	LAEVACGDDRKQTIDNSQGAYQEAF	LAEVACGDDRKQMIDNSQGAYQEAF	10.0	2.0	-	-	4240_2:9728454-9728454 G>A_LAEVACGDDRKQMIDNSQGAYQEAF	0.0
12:43944794-43944794 G>A	0.0	4186	BREAST	-	-	ID=COSM3792586,COSM3792587,COSM3792588;OCCURENCE=1(urinary_tract)	-	ADAMTS20	NM_025003,p.S124L|uc010skx.2,p.S124L|ENST00000553158,p.S124L|ENST00000389420,p.S124L	protein_coding	uc010skx.2	nonsynonymous SNV	exon2	c.C371T	p.S124L	PERGAWESDAGPSDLRHCFYRGQVN	PERGAWESDAGPLDLRHCFYRGQVN	1.0	5.0	-	-	4186_12:43944794-43944794 G>A_PERGAWESDAGPLDLRHCFYRGQVN	0.0
15:76630736-76630736 C>T	0.0	4301	MELANOMA	-	-	-	-	ISL2	NM_145805,p.S131L|ENST00000290759,p.S131L|uc002bbw.1,p.S131L	protein_coding, nonsense_mediated_decay	uc002bbw.1	nonsynonymous SNV	exon3	c.C392T	p.S131L	VCSRQLLPGDEFSLREHELLCRADH	VCSRQLLPGDEFLLREHELLCRADH	5.0	7.0	-	-	4301_15:76630736-76630736 C>T_VCSRQLLPGDEFLLREHELLCRADH	0.0
3:118942945-118942945 G>A	1.0	3795	MELANOMA	-	-	ID=COSM445350;OCCURENCE=1(breast)	-	B4GALT4	NM_003778,p.P212S|ENST00000467604,p.P212S|uc003ech.3,p.P212S|ENST00000359213,p.P212S|uc003eci.3,p.P212S|uc003ecg.3,p.P212S|uc003ece.1,p.P212S|ENST00000480814,p.P212S|ENST00000393765,p.P212S|uc011biy.2,p.P75S|NM_212543,p.P212S|ENST00000483209,p.P212S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011biy.2	nonsynonymous SNV	exon4	c.C223T	p.P75S	ENDFNLYKCEEHPKHLVVGRNSTGY	ENDFNLYKCEEHSKHLVVGRNSTGY	8.0	3.0	-	-	3795_3:118942945-118942945 G>A_ENDFNLYKCEEHSKHLVVGRNSTGY	0.0
2:33487859-33487859 C>T	1.0	3713	MELANOMA	-	-	-	-	LTBP1	uc010ymz.2,p.S504F|uc021vft.1,p.S830F|ENST00000413303,p.S158F|uc002rov.3,p.S451F|ENST00000402934,p.S451F|NM_206943,p.S830F|uc002rou.3,p.S504F|ENST00000407925,p.S504F|NM_001166265,p.S451F|ENST00000404525,p.S451F|ENST00000418533,p.S504F|NM_000627,p.S504F|ENST00000404816,p.S830F|NM_001166264,p.S504F|uc010yna.2,p.S451F|NM_001166266,p.S451F	protein_coding, processed_transcript	uc021vft.1	nonsynonymous SNV	exon14	c.C2489T	p.S830F	LEPGQPQLSPGISTIHLHPQFPVVI	LEPGQPQLSPGIFTIHLHPQFPVVI	4.0	8.0	-	-	3713_2:33487859-33487859 C>T_LEPGQPQLSPGIFTIHLHPQFPVVI	0.0
8:144995692-144995692 T>A	1.0	4298	COLORECTAL	-	-	-	-	PLEC	ENST00000345136,p.K2766M|uc003zaf.1,p.K2903M|ENST00000356346,p.K2752M|uc003zab.1,p.K2766M|uc003zac.1,p.K2770M|NM_000445,p.K2793M|uc003zae.1,p.K2734M|ENST00000354958,p.K2744M|NM_201384,p.K2766M|NM_201382,p.K2766M|ENST00000436759,p.K2793M|NM_201381,p.K2734M|uc003zag.1,p.K2744M|uc003zaj.2,p.K2793M|NM_201383,p.K2770M|uc003zah.2,p.K2752M|ENST00000398774,p.K2734M|ENST00000322810,p.K2903M|uc003zad.2,p.K2766M|NM_201379,p.K2744M|ENST00000527096,p.K2789M|NM_201380,p.K2903M|ENST00000357649,p.K2770M|ENST00000354589,p.K2766M|NM_201378,p.K2752M	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon33	c.A8378T	p.K2793M	VKEGVVGPELHHKLLSAERAVTGYK	VKEGVVGPELHHMLLSAERAVTGYK	10.0	3.0	-	-	4298_8:144995692-144995692 T>A_VKEGVVGPELHHMLLSAERAVTGYK	0.0
3:47035960-47035960 C>T	0.0	4245	COLORECTAL	-	-	-	-	NBEAL2	uc003cqq.1,p.R371C|NM_015175,p.R405C|ENST00000450053,p.R405C|ENST00000292309,p.R405C|uc003cqp.3,p.R405C	retained_intron, protein_coding, nonsense_mediated_decay	uc003cqq.1	nonsynonymous SNV	exon11	c.C1111T	p.R371C	SDSPSAKEVFKERIGYPHLQEVLQS	SDSPSAKEVFKECIGYPHLQEVLQS	10.0	9.0	CD8	-	4245_3:47035960-47035960 C>T_SDSPSAKEVFKECIGYPHLQEVLQS	1.0
4:5620363-5620363 T>C	0.0	4246	COLORECTAL	-	-	-	-	EVC2	ENST00000475313,p.R770G|NM_147127,p.R850G|uc003gij.3,p.R850G|NM_001166136,p.R770G|uc003gik.3,p.R770G|ENST00000310917,p.R770G|uc011bwb.2,p.R290G|ENST00000344938,p.R850G|ENST00000344408,p.R850G	protein_coding, nonsense_mediated_decay	uc011bwb.2	nonsynonymous SNV	exon16	c.A868G	p.R290G	SSVFSLSEEELLRMRQEVHGCFAQM	SSVFSLSEEELLGMRQEVHGCFAQM	3.0	1.0	-	-	4246_4:5620363-5620363 T>C_SSVFSLSEEELLGMRQEVHGCFAQM	0.0
8:89086857-89086857 C>T	1.0	3466	MELANOMA	-	-	-	-	MMP16	NM_005941,p.D400N|uc003yeb.4,p.D400N|ENST00000286614,p.D400N	retained_intron, protein_coding, processed_transcript	uc003yeb.4	nonsynonymous SNV	exon7	c.G1198A	p.D400N	LPPSIDAVYENSDGNFVFFKGNKYW	LPPSIDAVYENSNGNFVFFKGNKYW	8.0	8.0	-	-	3466_8:89086857-89086857 C>T_LPPSIDAVYENSNGNFVFFKGNKYW	0.0
1:91859811-91859811 A>T	0.0	4259	COLORECTAL	-	-	-	-	HFM1	NM_001017975,p.N111K	retained_intron, protein_coding, processed_transcript	NM_001017975	nonsynonymous SNV	exon4	c.T333A	p.N111K	YEQDDLNLEGVGNNDLSHVAGKLTY	YEQDDLNLEGVGKNDLSHVAGKLTY	2.0	7.0	-	-	4259_1:91859811-91859811 A>T_YEQDDLNLEGVGKNDLSHVAGKLTY	0.0
13:25671865-25671865 C>T	0.0	4326	BREAST	-	-	-	-	PABPC3	NM_030979,p.A510V|uc001upy.3,p.A510V|ENST00000281589,p.A510V	protein_coding	uc001upy.3	nonsynonymous SNV	exon1	c.C1529T	p.A510V	PAVRTVPRYKYAAGVRNPQQHRNAQ	PAVRTVPRYKYAVGVRNPQQHRNAQ	5.0	10.0	-	-	4326_13:25671865-25671865 C>T_PAVRTVPRYKYAVGVRNPQQHRNAQ	0.0
4:55561751-55561751 A>G	1.0	4316	COLORECTAL	-	-	-	1	KIT	NM_001093772,p.I47M|uc010igs.3,p.I47M|ENST00000412167,p.I47M|uc010igr.3,p.I47M|ENST00000288135,p.I47M|NM_000222,p.I47M	retained_intron, protein_coding	uc010igs.3	nonsynonymous SNV	exon2	c.A141G	p.I47M	SPPSIHPGKSDLIVRVGDEIRLLCT	SPPSIHPGKSDLMVRVGDEIRLLCT	7.0	10.0	-	-	4316_4:55561751-55561751 A>G_SPPSIHPGKSDLMVRVGDEIRLLCT	0.0
6:168442754-168442754 C>T	0.0	4110	BILE DUCT	-	-	-	-	KIF25	NM_030615,p.P251L|uc003qwl.1,p.P251L|ENST00000351261,p.P251L|uc003qwk.1,p.P251L|NM_005355,p.P251L|ENST00000443060,p.P251L|ENST00000354419,p.P251L	retained_intron, protein_coding, processed_transcript	uc003qwl.1	nonsynonymous SNV	exon7	c.C752T	p.P251L	RASQGALAPQLVPGNPAGHAEQVQA	RASQGALAPQLVLGNPAGHAEQVQA	4.0	9.0	-	-	4110_6:168442754-168442754 C>T_RASQGALAPQLVLGNPAGHAEQVQA	0.0
22:31495831-31495831 T>G	1.0	4345	COLORECTAL	-	-	-	-	SMTN	ENST00000347557,p.L851R|uc003ajl.2,p.L851R|uc003ajm.2,p.L851R|uc010gwe.2,p.L231R|NM_134270,p.L851R|uc003ajk.2,p.L851R|ENST00000404574,p.L374R|ENST00000358743,p.L851R|uc003ajn.2,p.L874R|NM_134269,p.L851R|uc003ajo.2,p.L374R|NM_006932,p.L851R|NM_001207017,p.L936R|uc011alf.2,p.L907R|ENST00000333137,p.L851R|uc011alg.2,p.L307R|uc011ale.2,p.L936R|NM_001207018,p.L907R	retained_intron, protein_coding, processed_transcript	uc011alg.2	nonsynonymous SNV	exon9	c.T920G	p.L307R	HNFFPEAFDYGQLSPQNRRQNFEVA	HNFFPEAFDYGQRSPQNRRQNFEVA	10.0	5.0	-	-	4345_22:31495831-31495831 T>G_HNFFPEAFDYGQRSPQNRRQNFEVA	0.0
4:90857287-90857287 A>G	0.0	2591	MELANOMA	-	-	-	-	MMRN1	ENST00000508372,p.N561S|uc003hst.3,p.N819S|ENST00000264790,p.N819S|uc011cds.2,p.N561S|NM_007351,p.N819S|ENST00000394980,p.N819S	retained_intron, protein_coding	uc011cds.2	nonsynonymous SNV	exon6	c.A1682G	p.N561S	AGIPRDEKLNQSNFQKMYQMFNETT	AGIPRDEKLNQSSFQKMYQMFNETT	1.0	10.0	-	-	2591_4:90857287-90857287 A>G_AGIPRDEKLNQSSFQKMYQMFNETT	0.0
X:122599628-122599628 G>A	0.0	4316	COLORECTAL	-	-	-	-	GRIA3	ENST00000371251,p.G810S|NM_000828,p.G810S|ENST00000264357,p.G810S|uc004etr.4,p.G810S	protein_coding, processed_transcript	uc004etr.4	nonsynonymous SNV	exon14	c.G2428A	p.G810S	WWYDKGECGSGGGDSKDKTSALSLS	WWYDKGECGSGGSDSKDKTSALSLS	2.0	6.0	-	-	4316_X:122599628-122599628 G>A_WWYDKGECGSGGSDSKDKTSALSLS	0.0
1:55183169-55183169 G>T	1.0	4237	NSCLC	-	-	-	-	TTC4	uc001cxx.4,p.Q78H|uc001cxv.3,p.Q89H|NM_001291333,p.Q78H|NM_004623,p.Q78H|ENST00000371281,p.Q78H	retained_intron, protein_coding	uc001cxx.4	nonsynonymous SNV	exon3	c.G234T	p.Q78H	SIIFDEERSPEEQAKTYKDEGNDYF	SIIFDEERSPEEHAKTYKDEGNDYF	8.0	6.0	-	-	4237_1:55183169-55183169 G>T_SIIFDEERSPEEHAKTYKDEGNDYF	0.0
19:58132004-58132004 C>A	1.0	4160	COLORECTAL	-	-	-	-	ZNF134	NM_003435,p.Q173K|uc002qpn.2,p.Q173K|ENST00000396161,p.Q173K	protein_coding, processed_transcript	uc002qpn.2	nonsynonymous SNV	exon3	c.C517A	p.Q173K	RSTESGDAFHGEQMHYKCSECGKAF	RSTESGDAFHGEKMHYKCSECGKAF	6.0	8.0	-	-	4160_19:58132004-58132004 C>A_RSTESGDAFHGEKMHYKCSECGKAF	0.0
15:23000161-23000216 GGCGTTTTGCTGTGCTGGATTTCTGCTACCATCTACTTAAAGTCCAGAAACATGAT>-	0.0	4258	ENDOMETRIAL	-	-	-	-	CYFIP1	uc001yus.3,p.R1172fs|NM_001287810,p.R1172fs|ENST00000560848,p.R1172fs|NM_001033028,p.R741fs|uc001yuu.3,p.R741fs|NM_014608,p.R1172fs|ENST00000435939,p.R741fs|ENST00000561263,p.R146fs|uc001yut.3,p.R1172fs|uc001yuv.3,p.R366fs|ENST00000313077,p.R1172fs	retained_intron, protein_coding, nonsense_mediated_decay	uc001yuv.3	frameshift deletion	exon9	c.1097_1152del	p.R366fs	AGCMIIVLLGQQRRFAVLDFCYHLL	AGCMIIVLLGQQRQR	9.0	1.0	-	-	4258_15:23000161-23000216 GGCGTTTTGCTGTGCTGGATTTCTGCTACCATCTACTTAAAGTCCAGAAACATGAT>-_AGCMIIVLLGQQRQR	0.0
15:86278850-86278850 G>A	1.0	2369	MELANOMA	-	-	-	-	AKAP13	ENST00000394518,p.G2501S|uc002blv.2,p.G2501S|uc002blx.2,p.G746S|uc031qtl.1,p.G1122S|NM_006738,p.G2505S|ENST00000394510,p.G746S|uc002blw.2,p.G966S|ENST00000361243,p.G2505S|NM_001270546,p.G1122S|uc002blu.2,p.G2505S|NM_007200,p.G2501S	retained_intron, protein_coding, processed_transcript	uc031qtl.1	nonsynonymous SNV	exon24	c.G3364A	p.G1122S	DGQDLRRTESDSGLKKGGNANLVFM	DGQDLRRTESDSSLKKGGNANLVFM	8.0	6.0	-	-	2369_15:86278850-86278850 G>A_DGQDLRRTESDSSLKKGGNANLVFM	0.0
19:10444159-10444159 G>A	1.0	4240	BREAST	-	-	-	-	RAVER1	ENST00000293677,p.H26Y|uc002moa.3,p.H26Y|NM_133452,p.H26Y	retained_intron, protein_coding, nonsense_mediated_decay	uc002moa.3	nonsynonymous SNV	exon1	c.C76T	p.H26Y	GFPKMAADVSVTHRPPLSPKSGAEV	GFPKMAADVSVTYRPPLSPKSGAEV	7.0	10.0	-	-	4240_19:10444159-10444159 G>A_GFPKMAADVSVTYRPPLSPKSGAEV	0.0
12:13716111-13716111 G>A	0.0	4301	MELANOMA	-	-	-	-	GRIN2B	ENST00000279593,p.S1354F|uc001rbt.2,p.S1354F|NM_000834,p.S1354F	protein_coding	uc001rbt.2	nonsynonymous SNV	exon13	c.C4061T	p.S1354F	MSAGESTFANNKSSVPTAGHHHHNN	MSAGESTFANNKFSVPTAGHHHHNN	3.0	6.0	-	-	4301_12:13716111-13716111 G>A_MSAGESTFANNKFSVPTAGHHHHNN	0.0
1:41475120-41475120 A>T	1.0	4237	NSCLC	-	-	-	-	CTPS1	ENST00000541520,p.H286L|uc001cgl.4,p.H517L|ENST00000372616,p.H517L|uc001cgk.4,p.H517L|NM_001301237,p.H361L|uc010ojq.2,p.H361L|NM_001905,p.H517L|uc010ojo.2,p.H286L|ENST00000372621,p.H517L	protein_coding, processed_transcript	uc010ojq.2	nonsynonymous SNV	exon13	c.A1082T	p.H361L	EGERMEIVELEDHPFFVGVQYHPEF	EGERMEIVELEDLPFFVGVQYHPEF	9.0	6.0	-	-	4237_1:41475120-41475120 A>T_EGERMEIVELEDLPFFVGVQYHPEF	0.0
17:7577539-7577539 G>A	1.0	4266	COLORECTAL	-	-	ID=COSM3388183,COSM120007,COSM120006,COSM10656,COSM120005,COSM1640831;OCCURENCE=61(breast),26(skin),9(biliary_tract),144(large_intestine),4(prostate),4(liver),2(kidney),11(pancreas),21(urinary_tract),31(ovary),4(soft_tissue),20(endometrium),20(lung),1(penis),4(thyroid),27(haematopoietic_and_lymphoid_tissue),1(pleura),1(cervix),28(stomach),33(central_nervous_system),45(oesophagus),1(vulva),1(bone),21(upper_aerodigestive_tract),1(NS)	1	TP53	NM_001126117,p.R116W|ENST00000413465,p.R248W|NM_001276760,p.R209W|NM_000546,p.R248W|ENST00000269305,p.R248W|ENST00000509690,p.R116W|uc002gin.3,p.R155W|NM_001126114,p.R248W|uc002gij.3,p.R209W|NM_001126116,p.R116W|NM_001276698,p.R89W|ENST00000455263,p.R248W|ENST00000420246,p.R248W|uc002gih.3,p.R248W|NM_001126115,p.R116W|uc002gii.2,p.R89W|NM_001276697,p.R89W|ENST00000445888,p.R248W|uc031qyq.1,p.R209W|uc002gig.1,p.R248W|NM_001276695,p.R209W|NM_001126112,p.R248W|NM_001126118,p.R209W|ENST00000359597,p.R248W|NM_001276761,p.R209W|NM_001126113,p.R248W|uc010cng.2,p.R89W|uc010cnf.2,p.R89W|NM_001276696,p.R209W|uc002gio.3,p.R116W|NM_001276699,p.R89W	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon6	c.C625T	p.R209W	YMCNSSCMGGMNRRPILTIITLEDS	YMCNSSCMGGMNWRPILTIITLEDS	10.0	10.0	CD8	-	4266_17:7577539-7577539 G>A_YMCNSSCMGGMNWRPILTIITLEDS	1.0
19:7592463-7592463 C>T	1.0	3919	MELANOMA	-	-	-	-	MCOLN1	ENST00000264079,p.T210I|uc002mgo.3,p.T210I|NM_020533,p.T210I	retained_intron, protein_coding	uc002mgo.3	nonsynonymous SNV	exon5	c.C629T	p.T210I	PERPPPPPSDDLTLLESSSSYKNLT	PERPPPPPSDDLILLESSSSYKNLT	8.0	7.0	-	-	3919_19:7592463-7592463 C>T_PERPPPPPSDDLILLESSSSYKNLT	0.0
16:57073734-57073734 C>T	1.0	3713	MELANOMA	-	-	-	-	NLRC5	uc021tiv.1,p.P753L|uc021tiw.1,p.P753L|ENST00000436936,p.P948L|ENST00000308149,p.P948L|ENST00000262510,p.P948L|ENST00000543030,p.P247L|uc021tiu.1,p.P948L|ENST00000538110,p.P455L|ENST00000539144,p.P948L|ENST00000538453,p.P99L|NM_032206,p.P948L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tiw.1	nonsynonymous SNV	exon11	c.C2258T	p.P753L	QHKTVIFMFAQEPEEQKGPQERAAF	QHKTVIFMFAQELEEQKGPQERAAF	10.0	9.0	-	-	3713_16:57073734-57073734 C>T_QHKTVIFMFAQELEEQKGPQERAAF	0.0
15:89389047-89389047 G>A	1.0	3919	MELANOMA	-	-	-	-	ACAN	uc010upp.1,p.A455T|ENST00000561243,p.A455T|NM_013227,p.A455T|ENST00000352105,p.A455T|ENST00000559004,p.A455T|ENST00000439576,p.A455T|uc010upo.1,p.A455T|ENST00000558207,p.A455T|NM_001135,p.A455T|uc002bmx.3,p.A455T	retained_intron, protein_coding	uc010upp.1	nonsynonymous SNV	exon7	c.G1363A	p.A455T	WGFPTPGLGPATAFTSEDLVVQVTA	WGFPTPGLGPATTFTSEDLVVQVTA	4.0	10.0	-	-	3919_15:89389047-89389047 G>A_WGFPTPGLGPATTFTSEDLVVQVTA	0.0
5:13844951-13844951 C>T	0.0	2591	MELANOMA	0.0014	-	-	-	DNAH5	uc003jfd.2,p.E1756K|ENST00000265104,p.E1756K|NM_001369,p.E1756K	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon32	c.G5266A	p.E1756K	NVFDNIKSVKFHEKIYDRILSISSQ	NVFDNIKSVKFHKKIYDRILSISSQ	1.0	5.0	-	-	2591_5:13844951-13844951 C>T_NVFDNIKSVKFHKKIYDRILSISSQ	0.0
6:116818135-116818135 ->G	0.0	4158	COLORECTAL	-	-	-	-	TRAPPC3L	uc003pww.3,p.K92fs|ENST00000437098,p.K162fs|ENST00000356128,p.K92fs|uc011ebh.2,p.K176fs|uc003pwx.3,p.K92fs|NM_001139444,p.K176fs|ENST00000368602,p.K176fs	protein_coding	uc011ebh.2	frameshift insertion	exon5	c.527_528insC	p.K176fs	IGITFLKKRDEKKYRGKK	IGITFLKKRDEKNI	6.0	4.0	-	-	4158_6:116818135-116818135 ->G_IGITFLKKRDEKNI	0.0
1:94471011-94471011 C>T	0.0	3775	CERVICAL	-	-	-	-	ABCA4	uc001dqh.3,p.E2045K|NM_000350,p.E2045K|uc001dqi.1,p.E164K|ENST00000536513,p.E315K|ENST00000535881,p.E164K|ENST00000370225,p.E2045K	protein_coding, processed_transcript	uc001dqi.1	nonsynonymous SNV	exon5	c.G490A	p.E164K	LYLYARLRGVPAEEIEKVANWSIKS	LYLYARLRGVPAKEIEKVANWSIKS	1.0	5.0	-	-	3775_1:94471011-94471011 C>T_LYLYARLRGVPAKEIEKVANWSIKS	0.0
19:6669933-6669933 C>T	0.0	4281	COLORECTAL	-	-	ID=COSM1564942;OCCURENCE=1(large_intestine)	-	TNFSF14	ENST00000599359,p.G50R|NM_003807,p.G50R|uc002mfk.2,p.G50R	protein_coding	uc002mfk.2	nonsynonymous SNV	exon2	c.G148A	p.G50R	VGLGLLLLLMGAGLAVQGWFLLQLH	VGLGLLLLLMGARLAVQGWFLLQLH	3.0	2.0	-	-	4281_19:6669933-6669933 C>T_VGLGLLLLLMGARLAVQGWFLLQLH	0.0
5:140594968-140594968 G>A	1.0	3713	MELANOMA	-	-	-	-	PCDHB13	NM_018933,p.D425N|ENST00000341948,p.D425N|uc003lja.1,p.D425N	protein_coding	uc003lja.1	nonsynonymous SNV	exon1	c.G1273A	p.D425N	SRAEYNITITVTDLGTPMLITQLNM	SRAEYNITITVTNLGTPMLITQLNM	2.0	9.0	-	-	3713_5:140594968-140594968 G>A_SRAEYNITITVTNLGTPMLITQLNM	0.0
5:31302286-31302286 G>A	0.0	3903	MELANOMA	-	-	-	-	CDH6	NM_004932,p.D294N|ENST00000514738,p.D239N|uc003jhd.2,p.D294N|uc003jhe.2,p.D294N|ENST00000265071,p.D294N	retained_intron, protein_coding	uc003jhe.2	nonsynonymous SNV	exon6	c.G880A	p.D294N	PPGTPIGRIKASDADVGENAEIEYS	PPGTPIGRIKASNADVGENAEIEYS	4.0	5.0	-	-	3903_5:31302286-31302286 G>A_PPGTPIGRIKASNADVGENAEIEYS	0.0
17:37900397-37900397 G>C	0.0	4149	OVARIAN	-	-	-	-	GRB7	NM_005310,p.W246C|ENST00000445327,p.W269C|uc021twu.1,p.W269C|ENST00000309185,p.W246C|uc002hsr.3,p.W246C|uc002hss.3,p.W246C|ENST00000394211,p.W246C|ENST00000394209,p.W246C|ENST00000394204,p.W246C|uc010cwc.3,p.W246C|NM_001242443,p.W246C|NM_001030002,p.W246C|uc002hst.3,p.W246C|NM_001242442,p.W269C|ENST00000309156,p.W246C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021twu.1	nonsynonymous SNV	exon7	c.G807C	p.W269C	GFLQLRGSGRKLWKRFFCFLRRSGL	GFLQLRGSGRKLCKRFFCFLRRSGL	4.0	9.0	-	-	4149_17:37900397-37900397 G>C_GFLQLRGSGRKLCKRFFCFLRRSGL	0.0
14:20928939-20928939 G>A	1.0	4155	MELANOMA	-	-	-	-	TMEM55B	uc001vxk.2,p.P77S|NM_144568,p.P70S|NM_001100814,p.P77S|ENST00000250489,p.P70S|uc001vxl.2,p.P70S|ENST00000398020,p.P77S	retained_intron, protein_coding	uc001vxl.2	nonsynonymous SNV	exon2	c.C208T	p.P70S	AVLPGEDPPPYSPLTSPDSGSAPMI	AVLPGEDPPPYSSLTSPDSGSAPMI	8.0	8.0	-	-	4155_14:20928939-20928939 G>A_AVLPGEDPPPYSSLTSPDSGSAPMI	0.0
20:16360121-16360121 G>C	1.0	4317	COLORECTAL	-	-	-	-	KIF16B	uc002wpf.1,p.D224E|ENST00000354981,p.D842E|uc002wpe.1,p.D224E|uc002wpg.2,p.D842E|NM_001199865,p.D842E|uc010gcj.2,p.D853E|uc010gci.2,p.D842E|ENST00000408042,p.D842E|ENST00000378003,p.D68E|ENST00000355755,p.D842E|uc010gch.2,p.D842E|NM_024704,p.D842E|NM_001199866,p.D842E	protein_coding	uc010gcj.2	nonsynonymous SNV	exon20	c.C2559G	p.D853E	RRQLVKLVNLEKDLVQQKDILKKEV	RRQLVKLVNLEKELVQQKDILKKEV	9.0	1.0	-	-	4317_20:16360121-16360121 G>C_RRQLVKLVNLEKELVQQKDILKKEV	0.0
X:7243418-7243418 C>T	1.0	3713	MELANOMA	-	-	-	-	STS	NM_000351,p.P379S|ENST00000217961,p.P379S|uc004cry.4,p.P379S	protein_coding	uc004cry.4	nonsynonymous SNV	exon8	c.C1135T	p.P379S	GKANNWEGGIRVPGILRWPRVIQAG	GKANNWEGGIRVSGILRWPRVIQAG	4.0	10.0	-	-	3713_X:7243418-7243418 C>T_GKANNWEGGIRVSGILRWPRVIQAG	0.0
3:121207970-121207970 G>A	1.0	2556	MELANOMA	-	-	-	1	POLQ	uc003eed.3,p.P442S|uc003eee.4,p.P1270S|NM_199420,p.P1270S|ENST00000264233,p.P1270S	protein_coding, processed_transcript	uc003eee.4	nonsynonymous SNV	exon16	c.C3808T	p.P1270S	DISRTVIPSEVLPSAGAFSKSEGQH	DISRTVIPSEVLSSAGAFSKSEGQH	6.0	7.0	-	-	2556_3:121207970-121207970 G>A_DISRTVIPSEVLSSAGAFSKSEGQH	0.0
19:10568698-10568698 T>G	0.0	4317	COLORECTAL	-	-	-	-	PDE4A	uc002moj.2,p.L341V|NM_001111307,p.L341V|ENST00000592685,p.L319V|ENST00000344979,p.L102V|ENST00000352831,p.L341V|ENST00000591971,p.L117V|ENST00000293683,p.L315V|NM_006202,p.L102V|uc002mok.2,p.L315V|uc021uow.1,p.L319V|uc002mom.2,p.L102V|NM_001111309,p.L280V|uc002mol.2,p.L280V|NM_001243121,p.L319V|ENST00000380702,p.L319V|NM_001111308,p.L315V|ENST00000440014,p.L280V	retained_intron, protein_coding, nonsense_mediated_decay	uc021uow.1	nonsynonymous SNV	exon10	c.T955G	p.L319V	LQPMSQITGLKKLMHSNSLNNSNIP	LQPMSQITGLKKVMHSNSLNNSNIP	8.0	3.0	-	-	4317_19:10568698-10568698 T>G_LQPMSQITGLKKVMHSNSLNNSNIP	0.0
9:79325538-79325538 G>A	1.0	3713	MELANOMA	-	-	-	-	PRUNE2	ENST00000376718,p.S551F|uc022bih.1,p.S373F|NM_015225,p.S551F|ENST00000428286,p.S192F|uc010mpk.3,p.S551F	protein_coding, processed_transcript	uc022bih.1	nonsynonymous SNV	exon7	c.C1118T	p.S373F	LDGMGTNMSNYSSSSLLSGAGKDSL	LDGMGTNMSNYSFSSLLSGAGKDSL	2.0	5.0	-	-	3713_9:79325538-79325538 G>A_LDGMGTNMSNYSFSSLLSGAGKDSL	0.0
3:186262111-186262111 G>C	1.0	4329	COLORECTAL	-	-	-	-	CRYGS	uc003fqe.3,p.S2C|ENST00000392499,p.S2C|uc031scs.1,p.S2C|ENST00000307944,p.S2C|NM_017541,p.S2C	retained_intron, protein_coding	uc031scs.1	nonsynonymous SNV	exon2	c.C5G	p.S2C	MSKTGTKITFYEDK	MCKTGTKITFYEDK	4.0	1.0	-	-	4329_3:186262111-186262111 G>C_MCKTGTKITFYEDK	0.0
13:32878059-32878059 C>A	0.0	2359	MELANOMA	-	-	-	-	ZAR1L	NM_001136571,p.R308I|ENST00000345108,p.R308I|ENST00000533490,p.R308I|uc010abc.1,p.R308I	protein_coding	uc010abc.1	nonsynonymous SNV	exon4	c.G923T	p.R308I	HRQELCGRCKDKRFSCGNIYSFKYV	HRQELCGRCKDKIFSCGNIYSFKYV	3.0	3.0	-	-	2359_13:32878059-32878059 C>A_HRQELCGRCKDKIFSCGNIYSFKYV	0.0
17:73625056-73625056 G>A	1.0	3678	MELANOMA	-	-	-	-	RECQL5	NM_004259,p.P816L|ENST00000582548,p.P156L|uc010dgk.3,p.P789L|ENST00000423245,p.P789L|ENST00000317905,p.P816L|uc010dgl.3,p.P816L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dgl.3	nonsynonymous SNV	exon16	c.C2447T	p.P816L	YTGEEDGAGGHSPAPPQTEECLRER	YTGEEDGAGGHSLAPPQTEECLRER	8.0	8.0	CD8	-	3678_17:73625056-73625056 G>A_YTGEEDGAGGHSLAPPQTEECLRER	1.0
5:33637697-33637697 G>T	0.0	4186	BREAST	-	-	-	-	ADAMTS12	NM_030955,p.P625T|ENST00000504830,p.P625T|uc003jia.1,p.P625T	protein_coding, processed_transcript	uc003jia.1	nonsynonymous SNV	exon12	c.C1873A	p.P625T	TVPYKNELYHWFPIFNPAHPCELYC	TVPYKNELYHWFTIFNPAHPCELYC	5.0	4.0	-	-	4186_5:33637697-33637697 G>T_TVPYKNELYHWFTIFNPAHPCELYC	0.0
3:155571624-155571624 C>G	1.0	4126	NSCLC	-	-	-	-	SLC33A1	NM_004733,p.D55H|uc003fan.4,p.D55H|ENST00000359479,p.D55H|NM_001190992,p.D55H|ENST00000392845,p.D55H|uc003fao.2,p.D55H	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fao.2	nonsynonymous SNV	exon1	c.G163C	p.D55H	AGREGDREALLGDTGTGDFLKAPQS	AGREGDREALLGHTGTGDFLKAPQS	7.0	7.0	-	-	4126_3:155571624-155571624 C>G_AGREGDREALLGHTGTGDFLKAPQS	0.0
14:105414443-105414443 C>T	1.0	4196	COLORECTAL	-	-	-	-	AHNAK2	NM_138420,p.V2449M|uc010axc.1,p.V2449M|ENST00000333244,p.V2449M|uc001ypx.2,p.V2349M	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.G7345A	p.V2449M	VMAPDVEVSQPSVEVDVEAPGAKLD	VMAPDVEVSQPSMEVDVEAPGAKLD	7.0	10.0	-	-	4196_14:105414443-105414443 C>T_VMAPDVEVSQPSMEVDVEAPGAKLD	0.0
12:112609047-112609047 G>C	1.0	3713	MELANOMA	-	-	-	-	HECTD4	uc021reb.1,p.R3802G|NM_001109662,p.R3802G|ENST00000377560,p.R3764G|ENST00000550722,p.R3790G|ENST00000430131,p.R3514G	retained_intron, protein_coding, processed_transcript	uc021reb.1	nonsynonymous SNV	exon68	c.C11404G	p.R3802G	VACLLNVPIESLRLRFALLQSLNTT	VACLLNVPIESLGLRFALLQSLNTT	4.0	9.0	-	-	3713_12:112609047-112609047 G>C_VACLLNVPIESLGLRFALLQSLNTT	0.0
14:102675789-102675789 C>T	1.0	3784	MELANOMA	-	-	-	-	WDR20	ENST00000335263,p.P428S|ENST00000556807,p.P367S|ENST00000454394,p.P459S|ENST00000556511,p.P367S|uc001ylf.3,p.P440S|NM_001242418,p.P440S|NM_001242416,p.P367S|uc010txu.2,p.P459S|uc001ylb.3,p.P367S|uc001yle.3,p.P367S|NM_181291,p.P428S|NM_181308,p.P367S|ENST00000499851,p.P171S|NM_001242417,p.P459S|ENST00000342702,p.P428S|uc001yld.3,p.P428S|uc001ykz.3,p.P428S|ENST00000545563,p.P255S|ENST00000424963,p.P304S|NM_144574,p.P428S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010txu.2	nonsynonymous SNV	exon4	c.C1375T	p.P459S	NSVTTPGNSVPPPLPRSNSLPHSAV	NSVTTPGNSVPPSLPRSNSLPHSAV	8.0	2.0	-	-	3784_14:102675789-102675789 C>T_NSVTTPGNSVPPSLPRSNSLPHSAV	0.0
12:12315300-12315300 G>T	1.0	3466	MELANOMA	-	-	-	-	LRP6	uc010shl.1,p.F702L|uc001rah.4,p.F702L|ENST00000543091,p.F702L|ENST00000261349,p.F702L|NM_002336,p.F702L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010shl.1	nonsynonymous SNV	exon10	c.C2106A	p.F702L	FMNGSALEHVVEFGLDYPEGMAVDW	FMNGSALEHVVELGLDYPEGMAVDW	9.0	4.0	-	-	3466_12:12315300-12315300 G>T_FMNGSALEHVVELGLDYPEGMAVDW	0.0
3:78688924-78688924 C>T	0.0	4346	COLORECTAL	-	-	-	-	ROBO1	NM_133631,p.D958N|uc003dqb.2,p.D964N|uc003dqd.2,p.D958N|uc011bgl.1,p.D575N|uc003dqe.2,p.D1003N|uc010hoh.2,p.D195N|ENST00000436010,p.D964N|NM_002941,p.D1003N|ENST00000495273,p.D958N|ENST00000464233,p.D1003N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bgl.1	nonsynonymous SNV	exon12	c.G1723A	p.D575N	SISCCTAGNGNSDSNLTTYSRPADC	SISCCTAGNGNSNSNLTTYSRPADC	5.0	4.0	-	-	4346_3:78688924-78688924 C>T_SISCCTAGNGNSNSNLTTYSRPADC	0.0
4:184626176-184626176 C>G	1.0	3713	MELANOMA	-	-	-	-	TRAPPC11	NM_021942,p.T1003S|uc003ivy.3,p.T609S|ENST00000334690,p.T1003S|uc003ivx.3,p.T1003S|uc010isc.3,p.T347S|ENST00000357207,p.T1003S|uc003ivw.3,p.T1003S|ENST00000512476,p.T609S|NM_199053,p.T1003S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010isc.3	nonsynonymous SNV	exon15	c.C1040G	p.T347S	AMENIPIITTVITLPHVIVENIPLH	AMENIPIITTVISLPHVIVENIPLH	6.0	4.0	-	-	3713_4:184626176-184626176 C>G_AMENIPIITTVISLPHVIVENIPLH	0.0
14:52509643-52509643 G>C	0.0	4316	COLORECTAL	-	-	-	-	NID2	uc001wzp.3,p.T479R|uc010tqs.2,p.T479R|ENST00000216286,p.T479R|NM_007361,p.T479R|uc001wzo.3,p.T479R|ENST00000541773,p.T426R|uc010tqt.1,p.T479R	retained_intron, protein_coding	uc010tqt.1	nonsynonymous SNV	exon6	c.C1436G	p.T479R	LEDNIGSNTEVFTYNAANKETCEHN	LEDNIGSNTEVFRYNAANKETCEHN	4.0	7.0	-	-	4316_14:52509643-52509643 G>C_LEDNIGSNTEVFRYNAANKETCEHN	0.0
7:38534086-38534086 C>T	1.0	4000	MELANOMA	-	-	-	-	AMPH	uc003tgu.3,p.E83K|ENST00000428293,p.E83K|NM_139316,p.E83K|ENST00000325590,p.E83K|uc003tgv.3,p.E83K|NM_001635,p.E83K|ENST00000356264,p.E83K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003tgv.3	nonsynonymous SNV	exon4	c.G247A	p.E83K	QEASMKLTESLHEVYEPDWYGREDV	QEASMKLTESLHKVYEPDWYGREDV	6.0	8.0	CD8	-	4000_7:38534086-38534086 C>T_QEASMKLTESLHKVYEPDWYGREDV	1.0
16:3065461-3065461 C>T	0.0	2591	MELANOMA	-	-	-	-	CLDN6	uc021tbb.1,p.G188R|ENST00000396925,p.G188R|NM_021195,p.G188R|uc002csu.4,p.G188R|ENST00000328796,p.G188R	protein_coding, nonsense_mediated_decay	uc021tbb.1	nonsynonymous SNV	exon1	c.G562A	p.G188R	LGGGLLCCTCPSGGSQGPSHYMARY	LGGGLLCCTCPSRGSQGPSHYMARY	1.0	7.0	-	-	2591_16:3065461-3065461 C>T_LGGGLLCCTCPSRGSQGPSHYMARY	0.0
5:140723728-140723728 C>T	0.0	3713	MELANOMA	-	-	-	-	PCDHGA3	ENST00000253812,p.S43F|NM_018916,p.S43F|NM_032011,p.S43F|uc003ljm.2,p.S43F|uc011dap.2,p.S43F	protein_coding	uc011dap.2	nonsynonymous SNV	exon1	c.C128T	p.S43F	IRYSVSEELDKGSFVGNIANDLGLE	IRYSVSEELDKGFFVGNIANDLGLE	3.0	9.0	-	-	3713_5:140723728-140723728 C>T_IRYSVSEELDKGFFVGNIANDLGLE	0.0
19:7532455-7532455 G>A	1.0	4266	COLORECTAL	-	-	-	-	ARHGEF18	uc002mgh.3,p.R776Q|uc002mgj.1,p.R571Q|uc010xjm.1,p.R776Q|NM_015318,p.R776Q|uc002mgi.3,p.R934Q|ENST00000319670,p.R776Q|ENST00000359920,p.R934Q|NM_001130955,p.R934Q	protein_coding	uc010xjm.1	nonsynonymous SNV	exon18	c.G2327A	p.R776Q	ERQRQAYQHDLERLREAQRAVERER	ERQRQAYQHDLEQLREAQRAVERER	7.0	10.0	-	-	4266_19:7532455-7532455 G>A_ERQRQAYQHDLEQLREAQRAVERER	0.0
16:58325019-58325019 G>A	0.0	3903	MELANOMA	-	-	-	-	PRSS54	uc002enf.3,p.S36F|NM_001080492,p.S36F|ENST00000567164,p.S36F|ENST00000219301,p.S36F|ENST00000569727,p.S36F|uc002eng.3,p.S36F	protein_coding, processed_transcript	uc002eng.3	nonsynonymous SNV	exon4	c.C107T	p.S36F	LYSSTSCGVQKASVFYGPDPKEGLV	LYSSTSCGVQKAFVFYGPDPKEGLV	1.0	7.0	-	-	3903_16:58325019-58325019 G>A_LYSSTSCGVQKAFVFYGPDPKEGLV	0.0
X:151128413-151128413 C>T	0.0	2591	MELANOMA	-	-	-	-	GABRE	uc004ffi.3,p.E228K|ENST00000370325,p.E228K|ENST00000370328,p.E228K|NM_004961,p.E228K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ffi.3	nonsynonymous SNV	exon6	c.G682A	p.E228K	FSYPENEMIYKWENFKLEINEKNSW	FSYPENEMIYKWKNFKLEINEKNSW	1.0	10.0	-	-	2591_X:151128413-151128413 C>T_FSYPENEMIYKWKNFKLEINEKNSW	0.0
4:100532596-100532596 C>A	1.0	4213	COLORECTAL	-	-	-	-	MTTP	ENST00000511045,p.L686I|uc011cej.2,p.L686I|uc003hvc.4,p.L659I|NM_001300785,p.L686I|ENST00000457717,p.L659I|ENST00000265517,p.L659I|NM_000253,p.L659I	protein_coding, nonsense_mediated_decay	uc011cej.2	nonsynonymous SNV	exon14	c.C2056A	p.L686I	NLNIFQYIGKAGLHGSQVVIEAQGL	NLNIFQYIGKAGIHGSQVVIEAQGL	4.0	8.0	-	-	4213_4:100532596-100532596 C>A_NLNIFQYIGKAGIHGSQVVIEAQGL	0.0
19:1109340-1109340 C>G	1.0	4237	NSCLC	-	-	-	-	SBNO2	ENST00000438103,p.R1043P|ENST00000587024,p.R1090P|ENST00000361757,p.R1100P|uc002lrj.4,p.R1043P|uc002lrk.4,p.R1100P|uc010dse.3,p.R1083P|NM_014963,p.R1100P|NM_001100122,p.R1043P	retained_intron, protein_coding	uc010dse.3	nonsynonymous SNV	exon29	c.G3248C	p.R1083P	GQFFTVYKPNIGRQSQLEALDSLRR	GQFFTVYKPNIGPQSQLEALDSLRR	10.0	2.0	-	-	4237_19:1109340-1109340 C>G_GQFFTVYKPNIGPQSQLEALDSLRR	0.0
3:41274911-41274911 T>A	1.0	2591	MELANOMA	-	-	ID=COSM131449;OCCURENCE=1(kidney),1(liver),1(large_intestine),1(prostate)	1	CTNNB1	ENST00000396185,p.N387K|ENST00000405570,p.N387K|NM_001098209,p.N387K|uc010hia.1,p.N387K|uc011azf.1,p.N380K|ENST00000453024,p.N380K|uc003ckq.2,p.N387K|uc003ckp.2,p.N387K|ENST00000396183,p.N387K|uc011azg.1,p.N315K|ENST00000349496,p.N387K|NM_001098210,p.N387K|NM_001904,p.N387K|uc003ckr.2,p.N387K	retained_intron, protein_coding, processed_transcript	uc011azg.1	nonsynonymous SNV	exon8	c.T945A	p.N315K	QRLVQNCLWTLRNLSDAATKQEGME	QRLVQNCLWTLRKLSDAATKQEGME	10.0	7.0	-	-	2591_3:41274911-41274911 T>A_QRLVQNCLWTLRKLSDAATKQEGME	0.0
1:156715098-156715098 G>A	1.0	4000	MELANOMA	-	-	-	-	HDGF	ENST00000416666,p.T20I|ENST00000368206,p.T68I|ENST00000357325,p.T52I|uc009wsf.3,p.T20I|uc009wsd.3,p.T20I|NM_001126051,p.T45I|uc010phr.2,p.T68I|uc009wse.3,p.T68I|ENST00000537739,p.T52I|ENST00000368209,p.T45I|NM_001126050,p.T68I|uc001fpy.4,p.T52I|uc001fpz.4,p.T45I|NM_004494,p.T52I	protein_coding, processed_transcript	uc010phr.2	nonsynonymous SNV	exon2	c.C203T	p.T68I	STANKYQVFFFGTHETAFLGPKDLF	STANKYQVFFFGIHETAFLGPKDLF	9.0	2.0	-	-	4000_1:156715098-156715098 G>A_STANKYQVFFFGIHETAFLGPKDLF	0.0
7:141464787-141464787 C>T	0.0	3903	MELANOMA	-	-	ID=COSM1699455;OCCURENCE=1(skin)	-	TAS2R3	uc003vwp.1,p.P277S|NM_016943,p.P277S|ENST00000247879,p.P277S	protein_coding	uc003vwp.1	nonsynonymous SNV	exon1	c.C829T	p.P277S	AKMIGEVMTMFYPAGHSFILILGNS	AKMIGEVMTMFYSAGHSFILILGNS	1.0	3.0	-	-	3903_7:141464787-141464787 C>T_AKMIGEVMTMFYSAGHSFILILGNS	0.0
7:140223218-140223218 C>T	0.0	2591	MELANOMA	-	-	-	-	DENND2A	ENST00000275884,p.D852N|ENST00000496613,p.D852N|uc010lnj.3,p.D852N|NM_015689,p.D852N|uc003vvw.3,p.D852N|ENST00000537639,p.D852N|uc010lnk.3,p.D852N	protein_coding, nonsense_mediated_decay	uc010lnk.3	nonsynonymous SNV	exon17	c.G2554A	p.D852N	DLVNSRFLRQMDDEDSILPRKLQVA	DLVNSRFLRQMDNEDSILPRKLQVA	1.0	9.0	-	-	2591_7:140223218-140223218 C>T_DLVNSRFLRQMDNEDSILPRKLQVA	0.0
11:10777291-10777291 C>A	0.0	4186	BREAST	-	-	-	-	CTR9	uc001mja.3,p.Q151K|ENST00000524523,p.Q138K|ENST00000361367,p.Q151K|NM_014633,p.Q151K	retained_intron, protein_coding	uc001mja.3	nonsynonymous SNV	exon4	c.C451A	p.Q151K	LLEGDKMDQADAQFHFVLNQSPNNI	LLEGDKMDQADAKFHFVLNQSPNNI	7.0	7.0	-	-	4186_11:10777291-10777291 C>A_LLEGDKMDQADAKFHFVLNQSPNNI	0.0
17:66985229-66985229 C>T	0.0	3795	MELANOMA	-	-	-	-	ABCA9	NM_080283,p.G1329E|ENST00000370732,p.G1329E|ENST00000340001,p.G1329E|ENST00000453985,p.G1291E|uc002jhu.3,p.G1329E|uc010dez.3,p.G1291E	retained_intron, protein_coding, processed_transcript	uc010dez.3	nonsynonymous SNV	exon29	c.G3872A	p.G1291E	KKGEVIGLLGHNGAGKSTTIKMITG	KKGEVIGLLGHNEAGKSTTIKMITG	5.0	9.0	-	-	3795_17:66985229-66985229 C>T_KKGEVIGLLGHNEAGKSTTIKMITG	0.0
11:13375862-13375862 G>T	1.0	4126	NSCLC	-	-	-	-	ARNTL	NM_001178,p.D3Y|ENST00000529388,p.D3Y|uc001mkq.3,p.D3Y|ENST00000533520,p.D3Y|ENST00000534544,p.D3Y|ENST00000527998,p.D3Y|NM_001297719,p.D3Y|ENST00000403290,p.D3Y|ENST00000361003,p.D3Y|ENST00000529050,p.D3Y|NM_001030272,p.D3Y|ENST00000531665,p.D3Y|NM_001297722,p.D3Y|uc001mkt.3,p.D3Y|uc001mkp.3,p.D3Y|uc001mkr.3,p.D3Y|ENST00000389708,p.D3Y|ENST00000389707,p.D3Y|ENST00000396441,p.D3Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001mkt.3	nonsynonymous SNV	exon4	c.G7T	p.D3Y	MADQRMDISSTISDF	MAYQRMDISSTISDF	7.0	5.0	-	-	4126_11:13375862-13375862 G>T_MAYQRMDISSTISDF	0.0
14:53513647-53513647 C>G	1.0	4244	COLORECTAL	-	-	-	-	DDHD1	uc001xag.3,p.D402H|ENST00000357758,p.D820H|NM_030637,p.D820H|NM_001160147,p.D827H|uc001xaj.3,p.D827H|ENST00000395606,p.D827H|uc001xah.3,p.D820H	retained_intron, protein_coding, processed_transcript	uc001xaj.3	nonsynonymous SNV	exon13	c.G2479C	p.D827H	FLDSALELDHRIDFELREGLVESRY	FLDSALELDHRIHFELREGLVESRY	6.0	1.0	-	-	4244_14:53513647-53513647 C>G_FLDSALELDHRIHFELREGLVESRY	0.0
9:132397525-132397525 C>T	1.0	4245	COLORECTAL	-	-	-	-	NTMT1	NM_001286797,p.R152C|ENST00000372486,p.R152C|ENST00000482347,p.R64C|NM_014064,p.R152C|ENST00000372483,p.R152C|NM_001286796,p.R152C|NM_001286799,p.R152C|NM_001286802,p.R64C|uc004byd.1,p.R152C|NM_001286803,p.R64C|NM_001286798,p.R152C|ENST00000372480,p.R152C	protein_coding, processed_transcript	uc004byd.1	nonsynonymous SNV	exon4	c.C454T	p.R152C	HLTDQHLAEFLRRCKGSLRPNGIIV	HLTDQHLAEFLRCCKGSLRPNGIIV	9.0	6.0	-	-	4245_9:132397525-132397525 C>T_HLTDQHLAEFLRCCKGSLRPNGIIV	0.0
6:41658952-41658952 G>A	1.0	3879	MELANOMA	-	-	-	1	TFEB	uc003oqx.2,p.H9Y	retained_intron, protein_coding	uc003oqx.2	nonsynonymous SNV	exon3	c.C25T	p.H9Y	MGASAGSHHGVTHRVAHAAHA	MGASAGSHYGVTHRVAHAAHA	5.0	1.0	-	-	3879_6:41658952-41658952 G>A_MGASAGSHYGVTHRVAHAAHA	0.0
1:15392253-15392253 C>T	1.0	3784	MELANOMA	-	-	-	-	KAZN	NM_001018000,p.T403I|uc001avo.2,p.T403I|NM_001018001,p.T315I|ENST00000422387,p.T409I|ENST00000400798,p.T315I|NM_001017999,p.T315I|uc009vog.1,p.T409I|uc001avp.2,p.T315I|NM_015209,p.T409I|uc001avq.2,p.T315I|ENST00000503743,p.T409I|ENST00000400797,p.T315I|ENST00000361144,p.T403I	retained_intron, protein_coding	uc009vog.1	nonsynonymous SNV	exon8	c.C1226T	p.T409I	QRKSLDPGLFDGTAPDYYIEEDADW	QRKSLDPGLFDGIAPDYYIEEDADW	8.0	2.0	-	-	3784_1:15392253-15392253 C>T_QRKSLDPGLFDGIAPDYYIEEDADW	0.0
9:132658109-132658109 C>A	1.0	4259	COLORECTAL	-	-	-	2	FNBP1	uc004byy.1,p.K524N|uc004byx.1,p.K534N|uc004byz.1,p.K589N|ENST00000355681,p.K589N	protein_coding, processed_transcript	uc004byz.1	nonsynonymous SNV	exon16	c.G1767T	p.K589N	VEVCLDKNAKGAKTYI	VEVCLDKNAKGANTYI	8.0	4.0	-	-	4259_9:132658109-132658109 C>A_VEVCLDKNAKGANTYI	0.0
2:25463191-25463191 C>A	1.0	4077	BILE DUCT	-	-	-	1	DNMT3A	NM_022552,p.D768Y|ENST00000402667,p.D545Y|NM_153759,p.D579Y|uc002rgc.4,p.D768Y|NM_175629,p.D768Y|ENST00000321117,p.D768Y|ENST00000264709,p.D768Y|uc002rgd.4,p.D768Y|uc002rgb.4,p.D579Y|ENST00000380746,p.D579Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rgd.4	nonsynonymous SNV	exon19	c.G2302T	p.D768Y	ENVVAMGVSDKRDISRFLESNPVMI	ENVVAMGVSDKRYISRFLESNPVMI	7.0	6.0	-	-	4077_2:25463191-25463191 C>A_ENVVAMGVSDKRYISRFLESNPVMI	0.0
20:51871441-51871441 G>A	0.0	4316	COLORECTAL	-	-	-	-	TSHZ2	NM_173485,p.E482K|ENST00000603338,p.E479K|NM_001193421,p.E479K|uc021wex.1,p.E479K|uc002xwo.3,p.E482K|ENST00000371497,p.E482K|ENST00000329613,p.E479K	protein_coding, processed_transcript	uc021wex.1	nonsynonymous SNV	exon2	c.G1435A	p.E479K	EETSKDEKVVKSEDYEDPLQKPLDP	EETSKDEKVVKSKDYEDPLQKPLDP	2.0	9.0	-	-	4316_20:51871441-51871441 G>A_EETSKDEKVVKSKDYEDPLQKPLDP	0.0
X:140993453-140993453 A>T	0.0	4129	NSCLC	-	-	-	-	MAGEC1	ENST00000285879,p.E88V|NM_005462,p.E88V|uc004fbt.3,p.E88V	protein_coding	uc004fbt.3	nonsynonymous SNV	exon4	c.A263T	p.E88V	SQSPLQIPQSSPEGDDTQSPLQNSQ	SQSPLQIPQSSPVGDDTQSPLQNSQ	1.0	10.0	-	-	4129_X:140993453-140993453 A>T_SQSPLQIPQSSPVGDDTQSPLQNSQ	0.0
X:53560337-53560337 A>G	1.0	4149	OVARIAN	-	-	-	-	HUWE1	uc004dsp.4,p.F4353S|NM_031407,p.F4353S|ENST00000262854,p.F4353S|ENST00000342160,p.F4353S|uc004dsn.4,p.F3161S	protein_coding, processed_transcript	uc004dsp.4	nonsynonymous SNV	exon84	c.T13058C	p.F4353S	CFNQLDLPAYESFEKLRHMLLLAIQ	CFNQLDLPAYESSEKLRHMLLLAIQ	10.0	9.0	CD8	-	4149_X:53560337-53560337 A>G_CFNQLDLPAYESSEKLRHMLLLAIQ	1.0
17:7099617-7099617 C>T	1.0	4244	COLORECTAL	-	-	-	-	DLG4	uc010cly.3,p.R405Q|uc002get.4,p.R451Q|uc010vto.2,p.R448Q|NM_001365,p.R451Q|ENST00000399510,p.R451Q|ENST00000399506,p.R408Q|uc010vtn.2,p.R348Q|NM_001128827,p.R405Q|ENST00000302955,p.R405Q	retained_intron, protein_coding, nonsense_mediated_decay	uc010vto.2	nonsynonymous SNV	exon13	c.G1343A	p.R448Q	EYSRFEAKIHDLREQLMNSSLGSGT	EYSRFEAKIHDLQEQLMNSSLGSGT	7.0	3.0	-	-	4244_17:7099617-7099617 C>T_EYSRFEAKIHDLQEQLMNSSLGSGT	0.0
16:30976444-30976444 C>T	1.0	3879	MELANOMA	-	-	-	-	SETD1A	uc002ead.1,p.R461C|ENST00000262519,p.R461C|NM_014712,p.R461C	protein_coding	uc002ead.1	nonsynonymous SNV	exon7	c.C1381T	p.R461C	PSPEREEVRTSPRPASPARSGSPAP	PSPEREEVRTSPCPASPARSGSPAP	5.0	9.0	-	-	3879_16:30976444-30976444 C>T_PSPEREEVRTSPCPASPARSGSPAP	0.0
X:2852912-2852912 G>C	0.0	3919	MELANOMA	-	-	-	-	ARSE	ENST00000540563,p.F532L|ENST00000381134,p.F577L|NM_001282631,p.F532L|ENST00000545496,p.F602L|uc011mhh.2,p.F602L|NM_001282628,p.F602L|uc004crc.4,p.F577L|NM_000047,p.F577L|uc011mhi.2,p.F523L	protein_coding, processed_transcript	uc011mhi.2	nonsynonymous SNV	exon10	c.C1569G	p.F523L	IWRPWLQPCCGPFPLCWCLREDDPQ	IWRPWLQPCCGPLPLCWCLREDDPQ	2.0	4.0	-	-	3919_X:2852912-2852912 G>C_IWRPWLQPCCGPLPLCWCLREDDPQ	0.0
1:33959982-33959982 C>T	1.0	2556	MELANOMA	-	-	-	-	ZSCAN20	uc001bxj.4,p.P680S|ENST00000361328,p.P680S|NM_145238,p.P680S|uc009vui.3,p.P679S	protein_coding, processed_transcript	uc009vui.3	nonsynonymous SNV	exon8	c.C2035T	p.P679S	ENENEDEGQWGNPSQEQWQESSSEE	ENENEDEGQWGNSSQEQWQESSSEE	5.0	4.0	-	-	2556_1:33959982-33959982 C>T_ENENEDEGQWGNSSQEQWQESSSEE	0.0
17:17797122-17797122 ->A	0.0	4245	COLORECTAL	-	-	-	-	TOM1L2	uc010vwy.2,p.V73fs|ENST00000535933,p.V73fs|ENST00000379504,p.V73fs|NM_001288786,p.V73fs|NM_001082968,p.V73fs|uc002grz.4,p.V73fs	retained_intron, protein_coding, processed_transcript	uc010vwy.2	frameshift insertion	exon4	c.218dupT	p.V73fs	NRNYREVMLALTVLETCVKNCGHRF	NRNYREVMLALTVAGDMCEELWPPLPHPCGQPRFHRQCSGQNYISQEQPSHHCTGQSACSDPGMG	7.0	6.0	-	-	4245_17:17797122-17797122 ->A_NRNYREVMLALTVAGDMCEELWPPLPHPCGQPRFHRQCSGQNYISQEQPSHHCTGQSACSDPGMG	0.0
6:99771425-99771425 C>T	1.0	4000	MELANOMA	-	-	-	-	FAXC	uc003ppj.4,p.G240R|NM_032511,p.G240R|ENST00000389677,p.G240R	protein_coding, processed_transcript	uc003ppj.4	nonsynonymous SNV	exon4	c.G718A	p.G240R	NLLRWVVCHITKGIVKREMHGHGIG	NLLRWVVCHITKRIVKREMHGHGIG	5.0	9.0	-	-	4000_6:99771425-99771425 C>T_NLLRWVVCHITKRIVKREMHGHGIG	0.0
9:69391124-69391124 C>T	0.0	4240	BREAST	-	-	-	-	ANKRD20A4	uc004afn.3,p.S211L|NM_001098805,p.S211L|ENST00000357336,p.S211L	retained_intron, protein_coding	uc004afn.3	nonsynonymous SNV	exon5	c.C632T	p.S211L	RRSALMLAVYYDSPGIVNILLKQNI	RRSALMLAVYYDLPGIVNILLKQNI	3.0	5.0	-	-	4240_9:69391124-69391124 C>T_RRSALMLAVYYDLPGIVNILLKQNI	0.0
6:37441358-37441358 A>C	1.0	4287	COLORECTAL	-	-	ID=COSM1444156;OCCURENCE=1(large_intestine)	-	CMTR1	uc003ons.3,p.K601T|NM_015050,p.K601T|ENST00000373451,p.K601T	protein_coding, processed_transcript, nonsense_mediated_decay	uc003ons.3	nonsynonymous SNV	exon17	c.A1802C	p.K601T	FDYRCMVSGSEQKFLIGLGKSQIYT	FDYRCMVSGSEQTFLIGLGKSQIYT	9.0	5.0	CD8	-	4287_6:37441358-37441358 A>C_FDYRCMVSGSEQTFLIGLGKSQIYT	1.0
2:88425751-88425751 C>T	0.0	3795	MELANOMA	0.0009	-	ID=COSM1205967;OCCURENCE=1(large_intestine)	-	FABP1	NM_001443,p.E62K|ENST00000295834,p.E62K|uc002sst.2,p.E62K|ENST00000393750,p.E62K	retained_intron, protein_coding, processed_transcript	uc002sst.2	nonsynonymous SNV	exon2	c.G184A	p.E62K	FTITAGSKVIQNEFTVGEECELETM	FTITAGSKVIQNKFTVGEECELETM	3.0	5.0	-	-	3795_2:88425751-88425751 C>T_FTITAGSKVIQNKFTVGEECELETM	0.0
4:85600165-85600165 A>T	1.0	3784	MELANOMA	-	-	-	-	WDFY3	ENST00000295888,p.S3352T|uc003hpc.3,p.S107T|ENST00000322366,p.S3335T|uc003hpd.3,p.S3352T|NM_014991,p.S3352T	retained_intron, protein_coding, processed_transcript	uc003hpd.3	nonsynonymous SNV	exon65	c.T10054A	p.S3352T	LDEKDGFIFVNYSEGQTRAHLQGPL	LDEKDGFIFVNYTEGQTRAHLQGPL	8.0	6.0	-	-	3784_4:85600165-85600165 A>T_LDEKDGFIFVNYTEGQTRAHLQGPL	0.0
22:26164460-26164460 G>A	0.0	2591	MELANOMA	-	-	-	-	MYO18B	uc010guz.1,p.G74R|ENST00000536101,p.G193R|uc003aca.1,p.G74R|NM_032608,p.G193R|uc010guy.1,p.G74R|ENST00000407587,p.G193R|uc003abz.1,p.G193R|ENST00000539302,p.G193R|ENST00000335473,p.G193R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010guz.1	nonsynonymous SNV	exon2	c.G220A	p.G74R	SPPATDTGKEKKGETSRTPCGSQAS	SPPATDTGKEKKRETSRTPCGSQAS	1.0	1.0	-	-	2591_22:26164460-26164460 G>A_SPPATDTGKEKKRETSRTPCGSQAS	0.0
5:122425854-122425854 C>T	0.0	4326	BREAST	-	-	-	-	PRDM6	uc003kti.3,p.P49S|ENST00000407847,p.P49S|NM_001136239,p.P49S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003kti.3	nonsynonymous SNV	exon2	c.C145T	p.P49S	GSGAAGLLSAPQPLQPPPPPPPPER	GSGAAGLLSAPQSLQPPPPPPPPER	4.0	4.0	-	-	4326_5:122425854-122425854 C>T_GSGAAGLLSAPQSLQPPPPPPPPER	0.0
19:13409932-13409932 G>A	0.0	4189	MELANOMA	-	-	-	-	CACNA1A	NM_001127222,p.R839W|uc021upt.1,p.R840W|NM_001127221,p.R840W|uc010dzc.2,p.R365W|ENST00000360228,p.R839W|ENST00000573710,p.R840W|uc002mwy.3,p.R839W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021upt.1	nonsynonymous SNV	exon19	c.C2518T	p.R840W	PQENRNNNTNKSRAAEPTVDQRLGQ	PQENRNNNTNKSWAAEPTVDQRLGQ	2.0	9.0	-	-	4189_19:13409932-13409932 G>A_PQENRNNNTNKSWAAEPTVDQRLGQ	0.0
1:232941569-232941569 C>T	0.0	4287	COLORECTAL	-	-	-	-	MAP10	uc001hvh.2,p.P267L|NM_019090,p.P267L|ENST00000418460,p.P267L	protein_coding	uc001hvh.2	nonsynonymous SNV	exon1	c.C800T	p.P267L	LATLLLQLPPGRPTPTPQLLGACDI	LATLLLQLPPGRLTPTPQLLGACDI	3.0	9.0	-	-	4287_1:232941569-232941569 C>T_LATLLLQLPPGRLTPTPQLLGACDI	0.0
8:8998635-8998635 G>T	1.0	2369	MELANOMA	-	-	-	-	PPP1R3B	NM_024607,p.P176H|NM_001201329,p.P176H|uc022arp.1,p.P176H|uc003wso.4,p.P176H|ENST00000519699,p.P176H|ENST00000310455,p.P176H|uc003wsn.4,p.P176H	protein_coding	uc022arp.1	nonsynonymous SNV	exon1	c.C527A	p.P176H	MTFDTWKSYTDFPCQYVKDTYAGSD	MTFDTWKSYTDFHCQYVKDTYAGSD	9.0	4.0	CD8	-	2369_8:8998635-8998635 G>T_MTFDTWKSYTDFHCQYVKDTYAGSD	1.0
5:140734966-140734966 G>A	0.0	4160	COLORECTAL	-	-	-	-	PCDHGA4	uc003ljp.1,p.V67I|ENST00000571252,p.V67I|NM_032053,p.V98I|NM_018917,p.V98I|uc003ljq.2,p.V67I	protein_coding	uc003ljq.2	nonsynonymous SNV	exon1	c.G199A	p.V67I	APRELAERGVRIVSRGRTQLFALNP	APRELAERGVRIISRGRTQLFALNP	3.0	5.0	-	-	4160_5:140734966-140734966 G>A_APRELAERGVRIISRGRTQLFALNP	0.0
13:20717281-20717281 C>A	0.0	4245	COLORECTAL	-	-	-	-	GJA3	uc001umx.1,p.Q49H|uc021rgz.1,p.Q49H|ENST00000241125,p.Q49H|NM_021954,p.Q49H	protein_coding	uc021rgz.1	nonsynonymous SNV	exon1	c.G147T	p.Q49H	LGAAAEDVWGDEQSDFTCNTQQPGC	LGAAAEDVWGDEHSDFTCNTQQPGC	2.0	3.0	-	-	4245_13:20717281-20717281 C>A_LGAAAEDVWGDEHSDFTCNTQQPGC	0.0
3:158320649-158320649 C>T	1.0	2591	MELANOMA	-	-	-	1	MLF1	uc010hvx.3,p.P140S|ENST00000484955,p.P183S|ENST00000482628,p.P183S|ENST00000478894,p.P198S|ENST00000491767,p.P134S|uc003fcc.3,p.P239S|ENST00000355893,p.P208S|ENST00000471745,p.P198S|NM_001195434,p.P198S|uc003fby.3,p.P134S|ENST00000392822,p.P239S|NM_022443,p.P208S|uc003fca.3,p.P183S|ENST00000498592,p.P163S|ENST00000469452,p.P140S|uc003fcb.3,p.P208S|ENST00000359117,p.P183S|NM_001195432,p.P239S|NM_001195433,p.P140S|uc003fbz.3,p.P183S|NM_001130157,p.P183S|uc003fbx.3,p.P198S|NM_001130156,p.P183S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010hvx.3	nonsynonymous SNV	exon6	c.C418T	p.P140S	DEEWQSEVLKYKPGRHNLGNTRMRS	DEEWQSEVLKYKSGRHNLGNTRMRS	7.0	10.0	-	-	2591_3:158320649-158320649 C>T_DEEWQSEVLKYKSGRHNLGNTRMRS	0.0
2:165953778-165953778 A>T	0.0	4238	COLORECTAL	-	-	-	-	SCN3A	ENST00000360093,p.L1408H|ENST00000409101,p.L1359H|NM_001081676,p.L1359H|uc002ucz.3,p.L1359H|NM_001081677,p.L1359H|uc002ucy.3,p.L1359H|ENST00000283254,p.L1408H|NM_006922,p.L1408H|uc002ucx.3,p.L1408H	retained_intron, protein_coding, processed_transcript	uc002ucz.3	nonsynonymous SNV	exon23	c.T4076A	p.L1359H	VKVNFDNVGAGYLALLQVATFKGWM	VKVNFDNVGAGYHALLQVATFKGWM	1.0	7.0	-	-	4238_2:165953778-165953778 A>T_VKVNFDNVGAGYHALLQVATFKGWM	0.0
X:48049693-48049693 C>A	0.0	4235	COLORECTAL	-	-	-	-	SSX5	uc004diz.1,p.E155D|NM_021015,p.E155D|ENST00000376923,p.E114D|uc004dja.1,p.E114D|NM_175723,p.E114D|ENST00000311798,p.E155D|ENST00000403001,p.E54D|ENST00000347757,p.E114D	protein_coding	uc004dja.1	nonsynonymous SNV	exon6	c.G342T	p.E114D	GRLQGIFPKITPEKPAEEGNDSKGV	GRLQGIFPKITPDKPAEEGNDSKGV	1.0	7.0	-	-	4235_X:48049693-48049693 C>A_GRLQGIFPKITPDKPAEEGNDSKGV	0.0
1:246755189-246755189 C>T	1.0	3879	MELANOMA	-	-	-	-	CNST	ENST00000366511,p.P109S|uc001ibp.3,p.P109S|ENST00000366513,p.P109S|uc001ibo.4,p.P109S|NM_152609,p.P109S|ENST00000366512,p.P109S|NM_001139459,p.P109S	protein_coding, processed_transcript	uc001ibp.3	nonsynonymous SNV	exon2	c.C325T	p.P109S	DEQAFLGKDKKIPGKRSPRSKKGTA	DEQAFLGKDKKISGKRSPRSKKGTA	10.0	9.0	-	-	3879_1:246755189-246755189 C>T_DEQAFLGKDKKISGKRSPRSKKGTA	0.0
18:12836873-12836873 T>C	1.0	4180	BREAST	-	-	-	-	PTPN2	ENST00000591497,p.K31E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000591497	nonsynonymous SNV	exon3	c.A91G	p.K31E	CRMQEIDDHSRVKLQNAENDYINAS	CRMQEIDDHSRVELQNAENDYINAS	9.0	9.0	-	-	4180_18:12836873-12836873 T>C_CRMQEIDDHSRVELQNAENDYINAS	0.0
18:43221197-43221197 G>A	0.0	2591	MELANOMA	-	-	-	-	SLC14A2	NM_001242692,p.E339K|uc010dnj.3,p.E339K|uc002lbb.3,p.E339K|NM_007163,p.E339K|ENST00000586448,p.E339K|uc002lbe.3,p.E339K|ENST00000255226,p.E339K	protein_coding, nonsense_mediated_decay	uc010dnj.3	nonsynonymous SNV	exon9	c.G1015A	p.E339K	GLLAALSVATPFETIYTGLWSYNCV	GLLAALSVATPFKTIYTGLWSYNCV	1.0	5.0	-	-	2591_18:43221197-43221197 G>A_GLLAALSVATPFKTIYTGLWSYNCV	0.0
12:48389087-48389087 G>A	0.0	2591	MELANOMA	-	-	-	1	COL2A1	uc001rqu.3,p.P238L|ENST00000337299,p.P169L|NM_001844,p.P238L|uc001rqv.3,p.P169L|ENST00000380518,p.P238L|NM_033150,p.P169L	retained_intron, protein_coding, processed_transcript	uc001rqv.3	nonsynonymous SNV	exon10	c.C506T	p.P169L	NPGEPGEPGVSGPMGPRGPPGPPGK	NPGEPGEPGVSGLMGPRGPPGPPGK	3.0	2.0	-	-	2591_12:48389087-48389087 G>A_NPGEPGEPGVSGLMGPRGPPGPPGK	0.0
16:67913600-67913600 C>T	1.0	3466	MELANOMA	-	-	-	-	EDC4	uc002eur.3,p.L582F|uc002eus.3,p.L312F|uc010vkg.1,p.L514F|NM_014329,p.L582F|ENST00000358933,p.L582F|uc010cer.3,p.L201F	retained_intron, protein_coding, processed_transcript	uc010vkg.1	nonsynonymous SNV	exon15	c.C1540T	p.L514F	RRIVELPAPADFLSLSSETKPKLMT	RRIVELPAPADFFSLSSETKPKLMT	9.0	7.0	-	-	3466_16:67913600-67913600 C>T_RRIVELPAPADFFSLSSETKPKLMT	0.0
11:65048551-65048551 A>G	1.0	4266	COLORECTAL	-	-	-	-	POLA2	NM_002689,p.H278R|ENST00000265465,p.H278R|ENST00000541089,p.H70R|uc010rod.1,p.H70R|uc001odj.3,p.H278R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rod.1	nonsynonymous SNV	exon7	c.A209G	p.H70R	NNKSVILEGDREHSSGAQIPVDLSE	NNKSVILEGDRERSSGAQIPVDLSE	8.0	6.0	-	-	4266_11:65048551-65048551 A>G_NNKSVILEGDRERSSGAQIPVDLSE	0.0
11:60468442-60468442 C>T	0.0	3795	MELANOMA	-	-	-	-	MS4A8	ENST00000300226,p.P37S|ENST00000529752,p.P37S|NM_031457,p.P37S|ENST00000532816,p.P37S|uc009yne.1,p.P37S|uc001npv.3,p.P37S	retained_intron, protein_coding, nonsense_mediated_decay	uc009yne.1	nonsynonymous SNV	exon2	c.C109T	p.P37S	VTPGIMSHVPLYPNSQPQVHLVPGN	VTPGIMSHVPLYSNSQPQVHLVPGN	3.0	9.0	-	-	3795_11:60468442-60468442 C>T_VTPGIMSHVPLYSNSQPQVHLVPGN	0.0
20:33028082-33028082 C>T	1.0	4160	COLORECTAL	-	-	-	-	ITCH	NM_001257137,p.L309F|ENST00000535650,p.L158F|NM_001257138,p.L158F|uc002xak.3,p.L268F|NM_031483,p.L268F|ENST00000374864,p.L268F|uc010geu.2,p.L309F|ENST00000262650,p.L309F|uc010zuj.2,p.L158F	protein_coding, processed_transcript	uc010zuj.2	nonsynonymous SNV	exon8	c.C472T	p.L158F	TSEGATSGLIIPLTISGGSGPRPLN	TSEGATSGLIIPFTISGGSGPRPLN	9.0	6.0	-	-	4160_20:33028082-33028082 C>T_TSEGATSGLIIPFTISGGSGPRPLN	0.0
9:6849697-6849697 C>T	1.0	3713	MELANOMA	-	-	-	-	KDM4C	uc003zkg.3,p.S209F|uc011lmi.1,p.S209F|NM_001146695,p.S209F|NM_001146696,p.S231F|uc010mhw.3,p.S209F|ENST00000442236,p.S28F|ENST00000381309,p.S209F|uc011lmk.2,p.S28F|ENST00000381306,p.S209F|NM_001146694,p.S209F|ENST00000543771,p.S209F|ENST00000536108,p.S28F|ENST00000535193,p.S231F|uc010mhu.2,p.S231F|NM_015061,p.S209F|uc003zkh.3,p.S209F|ENST00000438023,p.S209F	protein_coding, processed_transcript, nonsense_mediated_decay	uc011lmk.2	nonsynonymous SNV	exon4	c.C83T	p.S28F	YSINYLHFGEPKSWYAIPPEHGKRL	YSINYLHFGEPKFWYAIPPEHGKRL	6.0	6.0	-	-	3713_9:6849697-6849697 C>T_YSINYLHFGEPKFWYAIPPEHGKRL	0.0
7:100802357-100802357 C>G	1.0	4186	BREAST	-	-	-	-	AP1S1	ENST00000337619,p.I103M|uc003uxv.4,p.I103M|ENST00000443943,p.I103M|NM_001283,p.I103M	protein_coding, nonsense_mediated_decay	uc003uxv.4	nonsynonymous SNV	exon4	c.C309G	p.I103M	LDKYFGSVCELDIIFNFEKAYFILD	LDKYFGSVCELDMIFNFEKAYFILD	10.0	6.0	-	-	4186_7:100802357-100802357 C>G_LDKYFGSVCELDMIFNFEKAYFILD	0.0
6:110064361-110064361 T>A	1.0	4237	NSCLC	-	-	-	-	FIG4	uc003ptt.2,p.S309T|ENST00000230124,p.S309T|NM_014845,p.S309T	protein_coding	uc003ptt.2	nonsynonymous SNV	exon9	c.T925A	p.S309T	NEVETEQILCDASVMSFTAGSYSSY	NEVETEQILCDATVMSFTAGSYSSY	7.0	8.0	-	-	4237_6:110064361-110064361 T>A_NEVETEQILCDATVMSFTAGSYSSY	0.0
9:130575554-130575554 G>A	1.0	4158	COLORECTAL	-	-	-	-	FPGS	NM_001288803,p.E453K|uc004bsh.1,p.E296K|NM_001018078,p.E429K|ENST00000393706,p.E453K|uc011mal.1,p.E453K|ENST00000373225,p.E429K|uc004bsg.1,p.E479K|NM_004957,p.E479K|ENST00000373247,p.E479K|uc004bsi.1,p.E429K	protein_coding, processed_transcript	uc011mal.1	nonsynonymous SNV	exon14	c.G1357A	p.E453K	CLEHQQHWNHLDEEQASPDLWSAPS	CLEHQQHWNHLDKEQASPDLWSAPS	10.0	4.0	-	-	4158_9:130575554-130575554 G>A_CLEHQQHWNHLDKEQASPDLWSAPS	0.0
20:34061700-34061700 G>A	1.0	4317	COLORECTAL	-	-	-	-	CEP250	uc021wco.1,p.R465Q|NM_007186,p.R465Q|ENST00000342580,p.R465Q|ENST00000397527,p.R465Q|ENST00000425934,p.R464Q|ENST00000461386,p.R465Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wco.1	nonsynonymous SNV	exon14	c.G1394A	p.R465Q	DLQGEVDSLSKERELLQKAREELRQ	DLQGEVDSLSKEQELLQKAREELRQ	10.0	7.0	-	-	4317_20:34061700-34061700 G>A_DLQGEVDSLSKEQELLQKAREELRQ	0.0
19:54074922-54074922 C>T	1.0	3466	MELANOMA	-	-	-	1	ZNF331	uc002qca.1,p.S25F|ENST00000512387,p.S25F|ENST00000502248,p.S25F|ENST00000513999,p.S25F|uc002qcc.1,p.S25F|NM_001253798,p.S25F|uc002qby.1,p.S25F|ENST00000505949,p.S25F|ENST00000511567,p.S25F|ENST00000511154,p.S25F|uc021uzh.1,p.S25F|NM_001079906,p.S25F|NM_001253800,p.S25F|NM_001079907,p.S25F|ENST00000411977,p.S25F|uc010eqr.1,p.S25F|NM_001253801,p.S25F|uc002qcb.1,p.S25F|ENST00000509585,p.S25F|ENST00000509047,p.S25F|uc021uzg.1,p.S25F|ENST00000513265,p.S25F|uc002qbz.1,p.S25F|ENST00000253144,p.S25F|uc002qcd.1,p.S25F|NM_001253799,p.S25F|ENST00000514022,p.S25F|uc002qbx.1,p.S25F|NM_018555,p.S25F|ENST00000511593,p.S25F|ENST00000449416,p.S25F|ENST00000502616,p.S25F|ENST00000505426,p.S25F|ENST00000514374,p.S25F|ENST00000504493,p.S25F	retained_intron, protein_coding, processed_transcript	uc021uzh.1	nonsynonymous SNV	exon5	c.C74T	p.S25F	IDFSQEEWACLNSAQRDLYWDVMLE	IDFSQEEWACLNFAQRDLYWDVMLE	8.0	8.0	-	-	3466_19:54074922-54074922 C>T_IDFSQEEWACLNFAQRDLYWDVMLE	0.0
X:54784085-54784085 A>C	0.0	4213	COLORECTAL	-	-	-	-	ITIH6	uc004dtj.2,p.S808A|NM_198510,p.S808A|ENST00000218436,p.S808A	protein_coding, processed_transcript	uc004dtj.2	nonsynonymous SNV	exon8	c.T2422G	p.S808A	ALTSQAPKGLPQSRPGVSTLQVPKY	ALTSQAPKGLPQARPGVSTLQVPKY	3.0	4.0	-	-	4213_X:54784085-54784085 A>C_ALTSQAPKGLPQARPGVSTLQVPKY	0.0
7:100681079-100681079 G>A	0.0	4110	BILE DUCT	-	-	-	-	MUC17	NM_001040105,p.D2128N|ENST00000379439,p.D2128N|ENST00000306151,p.D2128N|uc003uxp.1,p.D2128N	retained_intron, protein_coding, nonsense_mediated_decay	uc003uxp.1	nonsynonymous SNV	exon3	c.G6382A	p.D2128N	SPEASTLSTTPVDSNSPVITSTEVS	SPEASTLSTTPVNSNSPVITSTEVS	1.0	10.0	-	-	4110_7:100681079-100681079 G>A_SPEASTLSTTPVNSNSPVITSTEVS	0.0
11:30352505-30352505 C>T	1.0	4000	MELANOMA	-	-	-	-	ARL14EP	ENST00000530909,p.P4S|NM_152316,p.P4S|ENST00000282032,p.P4S|uc001mso.1,p.P4S	retained_intron, protein_coding, processed_transcript	uc001mso.1	nonsynonymous SNV	exon2	c.C10T	p.P4S	MMDPCSVGVQLRTTNE	MMDSCSVGVQLRTTNE	10.0	1.0	-	-	4000_11:30352505-30352505 C>T_MMDSCSVGVQLRTTNE	0.0
12:27110579-27110579 T>C	1.0	4237	NSCLC	-	-	-	-	FGFR1OP2	ENST00000229395,p.I100T|uc001rhm.3,p.I100T|ENST00000327214,p.I100T|uc001rhl.3,p.I100T|ENST00000546072,p.I100T|uc001rhn.3,p.I100T|NM_015633,p.I100T|NM_001171888,p.I100T|NM_001171887,p.I100T	retained_intron, protein_coding	uc001rhn.3	nonsynonymous SNV	exon4	c.T299C	p.I100T	TSLEEHQSALELIMSKYREQMFRLL	TSLEEHQSALELTMSKYREQMFRLL	8.0	9.0	-	-	4237_12:27110579-27110579 T>C_TSLEEHQSALELTMSKYREQMFRLL	0.0
7:147844715-147844715 T>A	0.0	4110	BILE DUCT	-	-	-	2	CNTNAP2	ENST00000361727,p.L896Q|uc003weu.2,p.L896Q|NM_014141,p.L896Q	protein_coding, processed_transcript	uc003weu.2	nonsynonymous SNV	exon17	c.T2687A	p.L896Q	RVTAERNVKQASLQVDRLPQQIRKA	RVTAERNVKQASQQVDRLPQQIRKA	4.0	8.0	-	-	4110_7:147844715-147844715 T>A_RVTAERNVKQASQQVDRLPQQIRKA	0.0
2:198950193-198950193 C>T	1.0	4000	MELANOMA	-	-	-	-	PLCL1	NM_006226,p.S651F|uc002uuv.4,p.S572F|uc010fsp.3,p.S651F|ENST00000428675,p.S651F|ENST00000487695,p.S577F|ENST00000437704,p.S553F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010fsp.3	nonsynonymous SNV	exon2	c.C1952T	p.S651F	LSRIYPSAMRIDSSNLNPQDFWNCG	LSRIYPSAMRIDFSNLNPQDFWNCG	7.0	5.0	-	-	4000_2:198950193-198950193 C>T_LSRIYPSAMRIDFSNLNPQDFWNCG	0.0
17:39680490-39680490 G>A	1.0	3713	MELANOMA	-	-	-	-	KRT19	uc010wfs.2,p.H448Y|ENST00000361566,p.H285Y|ENST00000593096,p.H109Y|NM_002276,p.H285Y|uc002hxd.4,p.H285Y	retained_intron, protein_coding	uc010wfs.2	nonsynonymous SNV	exon8	c.C1342T	p.H448Y	SRTEELNREVAGHTEQLQMSRSEVT	SRTEELNREVAGYTEQLQMSRSEVT	4.0	10.0	-	-	3713_17:39680490-39680490 G>A_SRTEELNREVAGYTEQLQMSRSEVT	0.0
3:47158197-47158197 C>T	1.0	3784	MELANOMA	-	-	ID=COSM1423558,COSM1423557;OCCURENCE=2(large_intestine)	1	SETD2	ENST00000409792,p.C1501Y|NM_014159,p.C1501Y|uc003cqs.3,p.C1501Y|uc003cqv.3,p.C1490Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003cqv.3	nonsynonymous SNV	exon4	c.G4469A	p.C1490Y	KSHRDIKRMQCECTPLSKDERAQGE	KSHRDIKRMQCEYTPLSKDERAQGE	7.0	3.0	-	-	3784_3:47158197-47158197 C>T_KSHRDIKRMQCEYTPLSKDERAQGE	0.0
20:47351111-47351111 T>G	0.0	4345	COLORECTAL	-	-	-	-	PREX1	ENST00000396220,p.K164T|NM_020820,p.K164T|uc002xtw.1,p.K164T|ENST00000371941,p.K164T	protein_coding, processed_transcript, nonsense_mediated_decay	uc002xtw.1	nonsynonymous SNV	exon4	c.A491C	p.K164T	HEKALRLLVELNKIPTVRAFLLSCM	HEKALRLLVELNTIPTVRAFLLSCM	5.0	5.0	-	-	4345_20:47351111-47351111 T>G_HEKALRLLVELNTIPTVRAFLLSCM	0.0
17:80043004-80043004 C>T	1.0	4037	NSCLC	-	-	-	-	FASN	uc002kdu.3,p.R1439Q|uc002kdw.1,p.R655Q|NM_004104,p.R1439Q|ENST00000306749,p.R1439Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kdw.1	nonsynonymous SNV	exon11	c.G1964A	p.R655Q	SLKGILADEDSSRPVWLKAINCATS	SLKGILADEDSSQPVWLKAINCATS	10.0	10.0	-	-	4037_17:80043004-80043004 C>T_SLKGILADEDSSQPVWLKAINCATS	0.0
2:198571450-198571450 C>T	0.0	4246	COLORECTAL	-	-	-	-	MARS2	uc002uuq.3,p.R441C|NM_138395,p.R441C|ENST00000282276,p.R441C	protein_coding	uc002uuq.3	nonsynonymous SNV	exon1	c.C1321T	p.R441C	FPSEPGLVGPSVRAQAEDYALVSAV	FPSEPGLVGPSVCAQAEDYALVSAV	4.0	8.0	-	-	4246_2:198571450-198571450 C>T_FPSEPGLVGPSVCAQAEDYALVSAV	0.0
22:30057255-30057255 C>T	1.0	4189	MELANOMA	-	-	ID=COSM419603;OCCURENCE=1(urinary_tract)	1	NF2	NM_181830,p.P163L|ENST00000403435,p.P246L|uc003agf.4,p.P246L|ENST00000353887,p.P163L|ENST00000403999,p.P246L|ENST00000347330,p.P87L|uc003agi.4,p.P163L|ENST00000397789,p.P246L|ENST00000361166,p.P246L|NM_181831,p.P163L|ENST00000334961,p.P163L|NM_181829,p.P205L|uc003afy.4,p.P246L|uc003age.4,p.P246L|uc003agb.4,p.P169L|ENST00000338641,p.P246L|ENST00000361452,p.P205L|NM_181825,p.P246L|NM_181832,p.P246L|uc003agh.4,p.P205L|ENST00000432151,p.P87L|uc003agg.4,p.P246L|NM_181828,p.P204L|uc003agc.4,p.P208L|ENST00000361676,p.P204L|NM_016418,p.P246L|uc003afz.4,p.P163L|uc003aga.4,p.P204L|NM_000268,p.P246L	protein_coding, nonsense_mediated_decay	uc003agi.4	nonsynonymous SNV	exon6	c.C488T	p.P163L	LGVDALGLHIYDPENRLTPKISFPW	LGVDALGLHIYDLENRLTPKISFPW	9.0	1.0	-	-	4189_22:30057255-30057255 C>T_LGVDALGLHIYDLENRLTPKISFPW	0.0
19:13873436-13873436 G>A	1.0	4281	COLORECTAL	-	-	-	-	CCDC130	ENST00000586666,p.E200K|ENST00000586600,p.E249K|uc002mxc.1,p.E249K|ENST00000221554,p.E249K|NM_030818,p.E249K	retained_intron, protein_coding, processed_transcript	uc002mxc.1	nonsynonymous SNV	exon10	c.G745A	p.E249K	DSYEDKQKLKRTEIISRSWFPSAPG	DSYEDKQKLKRTKIISRSWFPSAPG	8.0	2.0	-	-	4281_19:13873436-13873436 G>A_DSYEDKQKLKRTKIISRSWFPSAPG	0.0
X:144904173-144904173 T>G	0.0	4266	COLORECTAL	-	-	-	-	SLITRK2	NM_001144008,p.L77R|uc004fcg.3,p.L77R|uc011mwt.2,p.L77R|NM_032539,p.L77R|ENST00000434188,p.L77R|ENST00000370490,p.L77R|NM_001144004,p.L77R|uc011mwr.2,p.L77R|uc010nsp.3,p.L77R|NM_001144005,p.L77R|ENST00000447897,p.L77R|uc011mwq.2,p.L77R|uc010nso.3,p.L77R|ENST00000335565,p.L77R|uc011mws.2,p.L77R|NM_001144010,p.L77R|ENST00000413937,p.L77R|NM_001144003,p.L77R|NM_001144009,p.L77R|NM_001144006,p.L77R|uc022cfn.1,p.L77R|uc004fcd.3,p.L77R|ENST00000428560,p.L77R	protein_coding	uc022cfn.1	nonsynonymous SNV	exon1	c.T230G	p.L77R	YQLFLNGNLLTRLYPNEFVNYSNAV	YQLFLNGNLLTRRYPNEFVNYSNAV	1.0	2.0	-	-	4266_X:144904173-144904173 T>G_YQLFLNGNLLTRRYPNEFVNYSNAV	0.0
18:12836873-12836873 T>C	1.0	4180	BREAST	-	-	-	-	PTPN2	ENST00000327283,p.K60E|NM_080423,p.K60E|NM_080422,p.K60E|NM_001207013,p.K60E|NM_002828,p.K60E|uc002krl.3,p.K60E|uc002krp.3,p.K60E|uc002krm.3,p.K60E|ENST00000592776,p.K60E|uc002krn.3,p.K60E|ENST00000591115,p.K60E|ENST00000309660,p.K60E|ENST00000353319,p.K60E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002krp.3	nonsynonymous SNV	exon3	c.A178G	p.K60E	YRDVSPYDHSRVKLQNAENDYINAS	YRDVSPYDHSRVELQNAENDYINAS	9.0	9.0	-	-	4180_18:12836873-12836873 T>C_YRDVSPYDHSRVELQNAENDYINAS	0.0
9:139686175-139686175 T>C	1.0	4180	BREAST	-	-	-	-	TMEM141	ENST00000290079,p.Y23H|uc011meg.1,p.Y23H|NM_032928,p.Y23H|uc004cje.4,p.Y23H	retained_intron, protein_coding, processed_transcript	uc011meg.1	nonsynonymous SNV	exon2	c.T67C	p.Y23H	DAVAAKHPGLGEYAACQSHAFMKGV	DAVAAKHPGLGEHAACQSHAFMKGV	10.0	9.0	-	-	4180_9:139686175-139686175 T>C_DAVAAKHPGLGEHAACQSHAFMKGV	0.0
11:62293428-62293428 G>A	1.0	3466	MELANOMA	-	-	-	-	AHNAK	NM_001620,p.P2821S|ENST00000378024,p.P2821S|uc001ntl.3,p.P2821S	protein_coding, processed_transcript	uc001ntl.3	nonsynonymous SNV	exon5	c.C8461T	p.P2821S	VNIEGPEGKWKSPKFKMPEMHFKTP	VNIEGPEGKWKSSKFKMPEMHFKTP	10.0	5.0	-	-	3466_11:62293428-62293428 G>A_VNIEGPEGKWKSSKFKMPEMHFKTP	0.0
2:198641827-198641827 C>T	0.0	4196	COLORECTAL	-	-	ID=COSM1404321,COSM1404320;OCCURENCE=1(breast),2(large_intestine),1(salivary_gland)	-	BOLL	ENST00000321801,p.V90I|uc002uut.2,p.V90I|NM_197970,p.V90I|NM_001284362,p.V84I|uc002uus.2,p.V78I|ENST00000430004,p.V78I|ENST00000392296,p.V78I|ENST00000433157,p.V78I|NM_033030,p.V78I|NM_001284361,p.V84I|uc002uuu.1,p.V84I|uc002uur.2,p.V84I	protein_coding, processed_transcript, nonsense_mediated_decay	uc002uuu.1	nonsynonymous SNV	exon4	c.G250A	p.V84I	NDRAGVSKGYGFVTFETQEDAQKIL	NDRAGVSKGYGFITFETQEDAQKIL	3.0	5.0	-	-	4196_2:198641827-198641827 C>T_NDRAGVSKGYGFITFETQEDAQKIL	0.0
X:30695558-30695558 A>C	1.0	3919	MELANOMA	-	-	-	-	GK	ENST00000378941,p.Y109S	protein_coding, nonsense_mediated_decay	ENST00000378941	nonsynonymous SNV	exon4	c.A326C	p.Y109S	TVVWDKITGEPLYNAVDCLTNE	TVVWDKITGEPLSNAVDCLTNE	4.0	4.0	-	-	3919_X:30695558-30695558 A>C_TVVWDKITGEPLSNAVDCLTNE	0.0
20:62836922-62836922 C>G	0.0	4046	OVARIAN	-	-	-	-	MYT1	uc002yii.3,p.L56V|ENST00000536311,p.L56V|ENST00000360149,p.L56V|NM_004535,p.L56V|ENST00000328439,p.L56V|uc002yih.3,p.L56V	protein_coding	uc002yii.3	nonsynonymous SNV	exon6	c.C166G	p.L56V	KYSRHRSLQSCPLAKKRKLEGAEAE	KYSRHRSLQSCPVAKKRKLEGAEAE	3.0	1.0	-	-	4046_20:62836922-62836922 C>G_KYSRHRSLQSCPVAKKRKLEGAEAE	0.0
16:20809516-20809516 G>A	1.0	3795	MELANOMA	-	-	-	-	ERI2	ENST00000357967,p.P536S|uc010vbc.1,p.P308S|uc010vbb.1,p.P536S|uc010bwh.2,p.P443S|uc002dht.3,p.P443S|ENST00000564349,p.P443S|ENST00000563117,p.P443S|NM_001142725,p.P536S|ENST00000389345,p.P271S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vbc.1	nonsynonymous SNV	exon8	c.C922T	p.P308S	KHPLLSGGTKRNPCSPQAFPPAKKQ	KHPLLSGGTKRNSCSPQAFPPAKKQ	7.0	4.0	-	-	3795_16:20809516-20809516 G>A_KHPLLSGGTKRNSCSPQAFPPAKKQ	0.0
10:62544576-62544576 G>A	1.0	2556	MELANOMA	-	-	-	-	CDK1	ENST00000316629,p.E51K|NM_001170406,p.E51K|ENST00000395284,p.E51K|uc001jlg.3,p.E51K|uc021prh.1,p.E51K|NM_033379,p.E51K|uc010qii.2,p.E51K|NM_001786,p.E51K|NM_001170407,p.E51K|ENST00000519078,p.E51K|ENST00000373809,p.E51K|ENST00000448257,p.E51K|uc001jld.3,p.E51K|uc031pvg.1,p.E51K	retained_intron, protein_coding, processed_transcript	uc031pvg.1	nonsynonymous SNV	exon3	c.G151A	p.E51K	SEEEGVPSTAIREISLLKELRHPNI	SEEEGVPSTAIRKISLLKELRHPNI	9.0	7.0	-	-	2556_10:62544576-62544576 G>A_SEEEGVPSTAIRKISLLKELRHPNI	0.0
15:78486316-78486316 G>A	0.0	2556	MELANOMA	-	-	-	-	ACSBG1	NM_001199377,p.S163F|uc010umw.2,p.S163F|uc002bdh.3,p.S167F|uc010umy.2,p.S60F|ENST00000559241,p.S175F|NM_015162,p.S167F|ENST00000558130,p.S163F|ENST00000258873,p.S167F|ENST00000559114,p.S60F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010umy.2	nonsynonymous SNV	exon3	c.C179T	p.S60F	KQAHSVAILGFNSPEWFFSAVGTVF	KQAHSVAILGFNFPEWFFSAVGTVF	3.0	3.0	-	-	2556_15:78486316-78486316 G>A_KQAHSVAILGFNFPEWFFSAVGTVF	0.0
15:101523808-101523808 G>A	1.0	3678	MELANOMA	-	-	-	-	LRRK1	ENST00000388948,p.E113K|ENST00000284395,p.E86K|uc002bwq.1,p.E113K|uc002bwr.3,p.E113K|NM_024652,p.E113K|ENST00000525284,p.E113K|ENST00000531270,p.E113K|ENST00000532029,p.E113K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002bwr.3	nonsynonymous SNV	exon4	c.G337A	p.E113K	EMVRYLLSKRLVELPTEPTDDNPAV	EMVRYLLSKRLVKLPTEPTDDNPAV	6.0	2.0	-	-	3678_15:101523808-101523808 G>A_EMVRYLLSKRLVKLPTEPTDDNPAV	0.0
19:40903036-40903036 G>A	0.0	4155	MELANOMA	-	-	-	-	PRX	ENST00000324001,p.P408L|uc002onr.3,p.P408L|NM_181882,p.P408L|uc002onq.3,p.P269L	protein_coding, processed_transcript	uc002onr.3	nonsynonymous SNV	exon7	c.C1223T	p.P408L	FGLSLLEPRPAAPEVVESKLKLPTI	FGLSLLEPRPAALEVVESKLKLPTI	3.0	5.0	-	-	4155_19:40903036-40903036 G>A_FGLSLLEPRPAALEVVESKLKLPTI	0.0
7:84629132-84629132 C>T	1.0	3713	MELANOMA	-	-	ID=COSM3833391;OCCURENCE=1(breast)	-	SEMA3D	ENST00000284136,p.R653Q|uc003uib.3,p.R292Q|uc003uic.3,p.R653Q|uc010led.3,p.R653Q|NM_152754,p.R653Q	retained_intron, protein_coding, processed_transcript	uc010led.3	nonsynonymous SNV	exon18	c.G1958A	p.R653Q	ERIIKTEYGLLIRSLQKKDSGMYYC	ERIIKTEYGLLIQSLQKKDSGMYYC	3.0	6.0	-	-	3713_7:84629132-84629132 C>T_ERIIKTEYGLLIQSLQKKDSGMYYC	0.0
12:52632464-52632464 G>A	0.0	3713	MELANOMA	-	-	-	-	KRT7	ENST00000331817,p.D200N|uc001saa.1,p.D200N|NM_005556,p.D200N	retained_intron, protein_coding, processed_transcript	uc001saa.1	nonsynonymous SNV	exon4	c.G598A	p.D200N	TAAENEFVVLKKDVDAAYMSKVELE	TAAENEFVVLKKNVDAAYMSKVELE	1.0	5.0	-	-	3713_12:52632464-52632464 G>A_TAAENEFVVLKKNVDAAYMSKVELE	0.0
7:150725677-150725677 C>G	1.0	4134	NSCLC	-	-	-	-	ABCB8	ENST00000297504,p.F25L|NM_001282291,p.F25L|uc003wil.4,p.F25L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003wil.4	nonsynonymous SNV	exon1	c.C75G	p.F25L	GPFPGRLLPPLRFQTFSAVRNTWRN	GPFPGRLLPPLRLQTFSAVRNTWRN	7.0	6.0	-	-	4134_7:150725677-150725677 C>G_GPFPGRLLPPLRLQTFSAVRNTWRN	0.0
10:21415013-21415013 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	C10orf113	uc001iqm.3,p.R69S|ENST00000377118,p.R59S|ENST00000534331,p.R69S|NM_001010896,p.R69S	protein_coding	uc001iqm.3	nonsynonymous SNV	exon2	c.G207T	p.R69S	PGKAERRAEKGLRPPRKLVGETRRL	PGKAERRAEKGLSPPRKLVGETRRL	1.0	4.0	-	-	4258_10:21415013-21415013 C>A_PGKAERRAEKGLSPPRKLVGETRRL	0.0
X:31227814-31227814 C>G	0.0	4240	BREAST	-	-	-	-	DMD	uc004dcp.1,p.D54H|ENST00000541735,p.D662H|NM_004019,p.D54H|uc004dda.1,p.D3122H|ENST00000378707,p.D662H|ENST00000361471,p.D54H|uc004dcr.1,p.D662H|NM_004010,p.D2999H|uc004ddb.1,p.D3114H|uc004dcw.2,p.D1778H|ENST00000343523,p.D662H|NM_004011,p.D1781H|uc004dcm.1,p.D54H|NM_000109,p.D3114H|NM_004022,p.D662H|ENST00000358062,p.D818H|uc004dcx.2,p.D1781H|ENST00000357033,p.D3122H|uc004dco.1,p.D54H|uc004dcy.1,p.D3118H|NM_004017,p.D54H|NM_004023,p.D662H|NM_004006,p.D3122H|NM_004015,p.D54H|NM_004009,p.D3118H|uc004dcn.1,p.D54H|uc004dcv.1,p.D662H|NM_004013,p.D662H|uc004dcs.1,p.D662H|ENST00000359836,p.D662H|ENST00000378723,p.D54H|ENST00000378680,p.D54H|NM_004016,p.D54H|ENST00000378677,p.D3118H|uc004dcu.1,p.D662H|ENST00000378702,p.D54H|NM_004014,p.D393H|uc004dct.1,p.D662H|NM_004018,p.D54H|uc004dcz.2,p.D2999H|NM_004012,p.D1778H|ENST00000474231,p.D662H|uc010ngm.3,p.D54H|uc004dcq.1,p.D393H|uc011mkb.1,p.D54H|NM_004020,p.D662H|NM_004021,p.D662H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mkb.1	nonsynonymous SNV	exon4	c.G160C	p.D54H	MKLRRLQKALCLDLLSLSAACDALD	MKLRRLQKALCLHLLSLSAACDALD	4.0	8.0	-	-	4240_X:31227814-31227814 C>G_MKLRRLQKALCLHLLSLSAACDALD	0.0
20:44512271-44512271 C>T	1.0	3919	MELANOMA	-	-	-	-	ZSWIM1	uc021wem.1,p.A347V|ENST00000372523,p.A347V|NM_080603,p.A347V|ENST00000372520,p.A347V|uc010ghi.3,p.A347V	protein_coding	uc021wem.1	nonsynonymous SNV	exon1	c.C1040T	p.A347V	TGPAAQLCLGELAVVQKSTHLIGSG	TGPAAQLCLGELVVVQKSTHLIGSG	5.0	2.0	-	-	3919_20:44512271-44512271 C>T_TGPAAQLCLGELVVVQKSTHLIGSG	0.0
5:89923114-89923114 G>T	0.0	4287	COLORECTAL	-	-	-	-	GPR98	NM_032119,p.E253D|ENST00000405460,p.E253D|uc003kju.3,p.E253D	retained_intron, protein_coding, processed_transcript	uc003kju.3	nonsynonymous SNV	exon7	c.G759T	p.E253D	GGAEINTSRNSIEIIIKKNDSPVRF	GGAEINTSRNSIDIIIKKNDSPVRF	5.0	8.0	-	-	4287_5:89923114-89923114 G>T_GGAEINTSRNSIDIIIKKNDSPVRF	0.0
6:74440247-74440247 C>T	1.0	2556	MELANOMA	-	-	-	-	CD109	NM_001159587,p.L153F|uc003phq.3,p.L153F|ENST00000437994,p.L153F|uc003php.3,p.L153F|ENST00000287097,p.L153F|NM_133493,p.L153F	protein_coding, processed_transcript	uc003phq.3	nonsynonymous SNV	exon4	c.C457T	p.L153F	KPKQEVKFRIVTLFSDFKPYKTSLN	KPKQEVKFRIVTFFSDFKPYKTSLN	10.0	6.0	-	-	2556_6:74440247-74440247 C>T_KPKQEVKFRIVTFFSDFKPYKTSLN	0.0
3:140997264-140997264 G>A	1.0	3879	MELANOMA	-	-	-	-	PXYLP1	NM_001282728,p.E16K|NM_001037172,p.E54K|ENST00000505013,p.E54K|ENST00000393007,p.E38K|NM_152282,p.E54K|ENST00000508812,p.E45K|ENST00000504264,p.E37K|ENST00000393010,p.E54K|ENST00000514680,p.E54K|ENST00000512457,p.E16K|ENST00000286353,p.E54K|uc011bnb.2,p.E37K|ENST00000502783,p.E16K|uc003etu.3,p.E54K|uc003etv.3,p.E54K|uc011bna.2,p.E16K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bnb.2	nonsynonymous SNV	exon2	c.G109A	p.E37K	KSRKRIMPDPVTEPPVTDPVYEALL	KSRKRIMPDPVTKPPVTDPVYEALL	6.0	10.0	-	-	3879_3:140997264-140997264 G>A_KSRKRIMPDPVTKPPVTDPVYEALL	0.0
X:92964801-92964801 G>A	1.0	3903	MELANOMA	-	-	-	-	FAM133A	ENST00000322139,p.G128E|NM_001171109,p.G128E|ENST00000538690,p.G128E|NM_001171111,p.G128E|uc022bzu.1,p.G128E|NM_173698,p.G128E|uc022bzv.1,p.G128E|uc022bzx.1,p.G128E|ENST00000355813,p.G128E|ENST00000332647,p.G128E|NM_001171110,p.G128E|uc004efr.2,p.G128E|uc022bzw.1,p.G128E	protein_coding	uc022bzx.1	nonsynonymous SNV	exon1	c.G383A	p.G128E	SSSDSEDEEKKQGKRRKKKKNRSYK	SSSDSEDEEKKQEKRRKKKKNRSYK	5.0	10.0	-	-	3903_X:92964801-92964801 G>A_SSSDSEDEEKKQEKRRKKKKNRSYK	0.0
4:87687627-87687627 C>G	1.0	4000	MELANOMA	-	-	-	1	PTPN13	NM_080685,p.A1434G|NM_080684,p.A1238G|uc003hqa.3,p.A1410G|uc003hqb.3,p.A1238G|uc003hpz.3,p.A1429G|NM_006264,p.A1410G|uc003hpy.3,p.A1434G|ENST00000436978,p.A1434G|ENST00000411767,p.A1429G|ENST00000316707,p.A1238G|ENST00000511467,p.A1434G|ENST00000427191,p.A1410G|NM_080683,p.A1429G	retained_intron, protein_coding	uc003hqb.3	nonsynonymous SNV	exon24	c.C3713G	p.A1238G	RVLAVNGVSLEGATHKQAVETLRNT	RVLAVNGVSLEGGTHKQAVETLRNT	6.0	3.0	-	-	4000_4:87687627-87687627 C>G_RVLAVNGVSLEGGTHKQAVETLRNT	0.0
6:97053784-97053784 G>A	0.0	4246	COLORECTAL	-	-	-	-	FHL5	NM_020482,p.R114H|ENST00000326771,p.R114H|ENST00000541107,p.R114H|ENST00000450218,p.R114H|uc003pos.2,p.R114H|NM_001170807,p.R114H|uc003pot.2,p.R114H	protein_coding	uc003pot.2	nonsynonymous SNV	exon4	c.G341A	p.R114H	CFHCKRTIMPGSRKMEFKGNYWHET	CFHCKRTIMPGSHKMEFKGNYWHET	4.0	9.0	-	-	4246_6:97053784-97053784 G>A_CFHCKRTIMPGSHKMEFKGNYWHET	0.0
11:6561133-6561133 C>A	1.0	4278	COLORECTAL	-	-	-	-	DNHD1	ENST00000254579,p.H1150N|NM_144666,p.H1150N|ENST00000527990,p.H1150N|uc001mdw.4,p.H1150N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001mdw.4	nonsynonymous SNV	exon18	c.C3448A	p.H1150N	INQVWQNENERIHAQETIRRLQRYW	INQVWQNENERINAQETIRRLQRYW	6.0	3.0	-	-	4278_11:6561133-6561133 C>A_INQVWQNENERINAQETIRRLQRYW	0.0
1:39920725-39920725 C>T	1.0	3713	MELANOMA	-	-	-	-	MACF1	ENST00000361689,p.P4952S|ENST00000317713,p.P4952S|uc031pme.1,p.P1008S|ENST00000289893,p.P5454S|ENST00000545844,p.P4952S|ENST00000372915,p.P6910S|ENST00000567887,p.P7048S|ENST00000539005,p.P4822S|NM_012090,p.P4952S|ENST00000564288,p.P7011S|uc021olt.1,p.P4952S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pme.1	nonsynonymous SNV	exon19	c.C3022T	p.P1008S	ETTLIQRDQEPIPQNIDRVKALIAE	ETTLIQRDQEPISQNIDRVKALIAE	10.0	7.0	-	-	3713_1:39920725-39920725 C>T_ETTLIQRDQEPISQNIDRVKALIAE	0.0
1:53925394-53925394 G>A	1.0	4284	COLORECTAL	-	-	-	-	DMRTB1	uc001cvq.1,p.V90I|ENST00000371445,p.V90I|NM_033067,p.V90I	protein_coding, processed_transcript	uc001cvq.1	nonsynonymous SNV	exon1	c.G268A	p.V90I	SGAAAAAPAPVPVPAASLRPLSPGT	SGAAAAAPAPVPIPAASLRPLSPGT	4.0	7.0	-	-	4284_1:53925394-53925394 G>A_SGAAAAAPAPVPIPAASLRPLSPGT	0.0
3:21467142-21467142 A>C	0.0	4238	COLORECTAL	-	-	-	-	ZNF385D	uc003cce.3,p.L232V|ENST00000281523,p.L232V|NM_024697,p.L232V	protein_coding, processed_transcript, nonsense_mediated_decay	uc003cce.3	nonsynonymous SNV	exon6	c.T694G	p.L232V	EAHNSGTKHKTMLEARNGSGTIKAF	EAHNSGTKHKTMVEARNGSGTIKAF	1.0	7.0	-	-	4238_3:21467142-21467142 A>C_EAHNSGTKHKTMVEARNGSGTIKAF	0.0
6:73830278-73830278 T>G	0.0	4213	COLORECTAL	-	-	-	-	KCNQ5	ENST00000402622,p.L400V|NM_001160132,p.L400V|uc011dyi.2,p.L400V	protein_coding	uc011dyi.2	nonsynonymous SNV	exon8	c.T1198G	p.L400V	VSIATWKPHLKALHTCSPTNKFCSN	VSIATWKPHLKAVHTCSPTNKFCSN	4.0	4.0	-	-	4213_6:73830278-73830278 T>G_VSIATWKPHLKAVHTCSPTNKFCSN	0.0
6:32096846-32096846 G>A	1.0	3713	MELANOMA	-	-	-	-	FKBPL	NM_022110,p.R238W|ENST00000375156,p.R238W|uc003nzr.3,p.R238W|uc021yvh.1,p.R238W	protein_coding	uc021yvh.1	nonsynonymous SNV	exon1	c.C712T	p.R238W	PEGAARCYGRALRLLLTLPPPGPPE	PEGAARCYGRALWLLLTLPPPGPPE	6.0	8.0	-	-	3713_6:32096846-32096846 G>A_PEGAARCYGRALWLLLTLPPPGPPE	0.0
7:77325860-77325860 C>A	0.0	4129	NSCLC	-	-	-	-	RSBN1L	ENST00000334955,p.P25Q|NM_198467,p.P25Q|uc010ldt.1,p.P25Q	retained_intron, protein_coding	uc010ldt.1	nonsynonymous SNV	exon1	c.C74A	p.P25Q	AAAPTATVSEKEPFGKLQLSSRDPP	AAAPTATVSEKEQFGKLQLSSRDPP	7.0	3.0	-	-	4129_7:77325860-77325860 C>A_AAAPTATVSEKEQFGKLQLSSRDPP	0.0
10:96342781-96342781 G>C	1.0	3775	CERVICAL	-	-	-	-	HELLS	ENST00000371332,p.E431Q|NM_001289067,p.E431Q|uc009xuo.3,p.E431Q	retained_intron, protein_coding, processed_transcript	uc009xuo.3	nonsynonymous SNV	exon12	c.G1291C	p.E431Q	SLSETAEDIIAKEREQNVLHMLHQE	SLSETAEDIIAKQREQNVLHMLHQE	9.0	7.0	-	-	3775_10:96342781-96342781 G>C_SLSETAEDIIAKQREQNVLHMLHQE	0.0
14:77944602-77944602 G>A	1.0	4317	COLORECTAL	0.0009	-	-	-	ISM2	ENST00000342219,p.T394M|uc001xtz.3,p.T394M|ENST00000412904,p.T313M|uc001xty.3,p.T306M|ENST00000393684,p.T306M|ENST00000429906,p.T313M|NM_199296,p.T394M	retained_intron, protein_coding, nonsense_mediated_decay	uc001xtz.3	nonsynonymous SNV	exon6	c.C1181T	p.T394M	PSEEWKLLARNATDMHDQDVDSCEK	PSEEWKLLARNAMDMHDQDVDSCEK	5.0	10.0	-	-	4317_14:77944602-77944602 G>A_PSEEWKLLARNAMDMHDQDVDSCEK	0.0
14:24884053-24884053 C>T	0.0	4155	MELANOMA	-	-	-	-	NYNRIN	NM_025081,p.S1033F|uc001wpf.4,p.S1033F|ENST00000382554,p.S1033F	protein_coding, processed_transcript	uc001wpf.4	nonsynonymous SNV	exon9	c.C3098T	p.S1033F	SSLASVFRVECPSLSEEILRCLSLH	SSLASVFRVECPFLSEEILRCLSLH	4.0	9.0	-	-	4155_14:24884053-24884053 C>T_SSLASVFRVECPFLSEEILRCLSLH	0.0
11:59837686-59837686 T>C	0.0	4301	MELANOMA	-	-	-	-	MS4A3	uc001nom.3,p.S209P|NM_006138,p.S209P|ENST00000534744,p.S163P|ENST00000358152,p.S163P|NM_001031666,p.S86P|uc001non.3,p.S163P|NM_001031809,p.S163P|uc001noo.3,p.S86P|ENST00000395032,p.S86P|ENST00000278865,p.S209P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001noo.3	nonsynonymous SNV	exon5	c.T256C	p.S86P	NANCCNSREEISSPPNSV	NANCCNSREEISPPPNSV	2.0	4.0	-	-	4301_11:59837686-59837686 T>C_NANCCNSREEISPPPNSV	0.0
7:89793972-89793972 A>C	1.0	4320	COLORECTAL	-	-	-	-	STEAP1	uc003ujx.3,p.K315T|ENST00000297205,p.K315T|NM_012449,p.K315T	retained_intron, protein_coding, nonsense_mediated_decay	uc003ujx.3	nonsynonymous SNV	exon5	c.A944C	p.K315T	IFKSILFLPCLRKKILKIRHGWEDV	IFKSILFLPCLRTKILKIRHGWEDV	8.0	2.0	-	-	4320_7:89793972-89793972 A>C_IFKSILFLPCLRTKILKIRHGWEDV	0.0
15:54919201-54919201 G>A	0.0	4316	COLORECTAL	-	-	-	-	UNC13C	uc002acm.3,p.E100K|ENST00000545554,p.E2179K|ENST00000539562,p.E100K|uc021sms.1,p.E2179K|NM_001080534,p.E2179K|ENST00000260323,p.E2179K|ENST00000537900,p.E2177K	retained_intron, protein_coding	uc021sms.1	nonsynonymous SNV	exon32	c.G6535A	p.E2179K	AWYPLLKNISMDETGLTILRILSQR	AWYPLLKNISMDKTGLTILRILSQR	1.0	10.0	-	-	4316_15:54919201-54919201 G>A_AWYPLLKNISMDKTGLTILRILSQR	0.0
8:87638300-87638300 C>T	0.0	4246	COLORECTAL	-	-	ID=COSM3716089;OCCURENCE=1(upper_aerodigestive_tract)	-	CNGB3	uc003ydx.3,p.D497N|NM_019098,p.D497N|ENST00000320005,p.D497N|uc010maj.3,p.D359N	protein_coding, processed_transcript	uc010maj.3	nonsynonymous SNV	exon10	c.G1075A	p.D359N	YTWDSQRMLDESDLLKTLPTTVQLA	YTWDSQRMLDESNLLKTLPTTVQLA	3.0	6.0	-	-	4246_8:87638300-87638300 C>T_YTWDSQRMLDESNLLKTLPTTVQLA	0.0
17:41003468-41003468 C>A	0.0	4316	COLORECTAL	-	-	-	-	AOC3	uc031rao.1,p.S36R|NM_003734,p.S36R|uc002ibv.4,p.S36R|NM_001277731,p.S36R|ENST00000308423,p.S36R	protein_coding, nonsense_mediated_decay	uc031rao.1	nonsynonymous SNV	exon1	c.C108A	p.S36R	LLVGRGGDGGEPSQLPHCPSVSPSA	LLVGRGGDGGEPRQLPHCPSVSPSA	4.0	6.0	-	-	4316_17:41003468-41003468 C>A_LLVGRGGDGGEPRQLPHCPSVSPSA	0.0
6:42797240-42797240 C>T	1.0	4298	COLORECTAL	-	-	-	-	GLTSCR1L	uc011duw.1,p.P390L|ENST00000314073,p.P390L|NM_015349,p.P390L|uc003osn.1,p.P390L|uc003oso.1,p.P390L|ENST00000394168,p.P390L|uc003osm.1,p.P390L|uc003osp.1,p.P390L	protein_coding	uc011duw.1	nonsynonymous SNV	exon5	c.C1169T	p.P390L	VSSTGGSIVIHSPMGQPHAPQSQFL	VSSTGGSIVIHSLMGQPHAPQSQFL	6.0	7.0	-	-	4298_6:42797240-42797240 C>T_VSSTGGSIVIHSLMGQPHAPQSQFL	0.0
12:118575943-118575943 C>T	1.0	3466	MELANOMA	-	-	-	-	PEBP1	uc001twu.1,p.P79S|NM_002567,p.P79S|ENST00000261313,p.P79S|uc010szc.1,p.P79S	protein_coding, processed_transcript	uc010szc.1	nonsynonymous SNV	exon2	c.C235T	p.P79S	VLTDPDAPSRKDPKYREWHHFLVVN	VLTDPDAPSRKDSKYREWHHFLVVN	10.0	9.0	-	-	3466_12:118575943-118575943 C>T_VLTDPDAPSRKDSKYREWHHFLVVN	0.0
1:225284824-225284824 T>G	0.0	4345	COLORECTAL	-	-	-	-	DNAH14	ENST00000430092,p.L1193R|NM_001373,p.L1193R|ENST00000439375,p.L1193R|ENST00000328556,p.L271R|uc001how.2,p.L1193R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001how.2	nonsynonymous SNV	exon22	c.T3578G	p.L1193R	IKGSPHIGPIKDLVNEWDQNLTLFS	IKGSPHIGPIKDRVNEWDQNLTLFS	7.0	2.0	-	-	4345_1:225284824-225284824 T>G_IKGSPHIGPIKDRVNEWDQNLTLFS	0.0
17:13504388-13504388 C>A	0.0	4160	COLORECTAL	-	-	-	-	HS3ST3A1	uc002gob.1,p.S20I|ENST00000284110,p.S20I|NM_006042,p.S20I	protein_coding	uc002gob.1	nonsynonymous SNV	exon1	c.G59T	p.S20I	SALSTSAEPLSRSIFRKFLLMLCSL	SALSTSAEPLSRIIFRKFLLMLCSL	3.0	10.0	-	-	4160_17:13504388-13504388 C>A_SALSTSAEPLSRIIFRKFLLMLCSL	0.0
5:14508311-14508311 A>T	1.0	4345	COLORECTAL	-	-	-	-	TRIO	ENST00000537187,p.E2849V|ENST00000344204,p.E3025V|ENST00000344135,p.E524V|uc003jff.3,p.E3025V|NM_007118,p.E3025V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jff.3	nonsynonymous SNV	exon57	c.A9074T	p.E3025V	DDYFKGVSQKAKEFVCFLLQEDPAK	DDYFKGVSQKAKVFVCFLLQEDPAK	10.0	2.0	-	-	4345_5:14508311-14508311 A>T_DDYFKGVSQKAKVFVCFLLQEDPAK	0.0
1:49242497-49242497 C>T	0.0	4160	COLORECTAL	-	-	-	-	BEND5	NM_024603,p.A3T|ENST00000371833,p.A3T|uc001crx.4,p.A3T	retained_intron, protein_coding, processed_transcript	uc001crx.4	nonsynonymous SNV	exon1	c.G7A	p.A3T	MYAFVRFLEDNVCYA	MYTFVRFLEDNVCYA	4.0	2.0	-	-	4160_1:49242497-49242497 C>T_MYTFVRFLEDNVCYA	0.0
5:167673790-167673790 G>A	0.0	4245	COLORECTAL	-	-	ID=COSM3338269,COSM3697121,COSM3338268,COSM3338267;OCCURENCE=1(large_intestine)	-	TENM2	ENST00000403607,p.R1773H|NM_001122679,p.R1940H|ENST00000518659,p.R1949H|uc010jje.3,p.R1204H|uc003lzr.5,p.R1710H|uc003lzt.4,p.R1313H|ENST00000545108,p.R1948H|ENST00000519204,p.R1828H|uc010jjd.3,p.R1940H|ENST00000520394,p.R1710H	retained_intron, protein_coding, processed_transcript	uc010jje.3	nonsynonymous SNV	exon16	c.G3611A	p.R1204H	LDKSMVLLLQSQRQYIFEYDSSDRL	LDKSMVLLLQSQHQYIFEYDSSDRL	2.0	6.0	-	-	4245_5:167673790-167673790 G>A_LDKSMVLLLQSQHQYIFEYDSSDRL	0.0
7:17937050-17937050 C>A	1.0	4000	MELANOMA	-	-	-	-	SNX13	uc003stw.1,p.G11V|ENST00000409604,p.G11V|uc003sty.3,p.G11V|ENST00000409076,p.G11V|ENST00000409389,p.G11V|uc003stv.3,p.G11V|ENST00000444712,p.G11V|NM_015132,p.G11V|ENST00000428135,p.G11V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003sty.3	nonsynonymous SNV	exon2	c.G32T	p.G11V	MLTEASLSIWGWGSLGIVLFLIT	MLTEASLSIWVWGSLGIVLFLIT	9.0	1.0	-	-	4000_7:17937050-17937050 C>A_MLTEASLSIWVWGSLGIVLFLIT	0.0
X:41075846-41075846 A>G	1.0	4046	OVARIAN	-	-	-	-	USP9X	ENST00000378308,p.Y2009C|NM_001039590,p.Y2009C|uc004dfb.3,p.Y2009C|uc004dfc.3,p.Y2009C|NM_001039591,p.Y2009C|ENST00000324545,p.Y2009C	retained_intron, protein_coding, nonsense_mediated_decay	uc004dfc.3	nonsynonymous SNV	exon35	c.A6026G	p.Y2009C	QFMHNRMQYSMEYFQFMKKLLTCNG	QFMHNRMQYSMECFQFMKKLLTCNG	8.0	6.0	CD8	-	4046_X:41075846-41075846 A>G_QFMHNRMQYSMECFQFMKKLLTCNG	1.0
3:178921553-178921553 T>A	1.0	4244	COLORECTAL	-	-	ID=COSM754,COSM132748;OCCURENCE=1(lung),5(central_nervous_system),1(stomach),44(breast),4(large_intestine),1(prostate),2(urinary_tract),5(endometrium),1(salivary_gland)	1	PIK3CA	ENST00000263967,p.N345K|NM_006218,p.N345K|uc003fjk.3,p.N345K	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon5	c.T1035A	p.N345K	ALRIKILCATYVNVNIRDIDKIYVR	ALRIKILCATYVKVNIRDIDKIYVR	6.0	10.0	-	-	4244_3:178921553-178921553 T>A_ALRIKILCATYVKVNIRDIDKIYVR	0.0
5:178552033-178552033 G>A	0.0	4259	COLORECTAL	-	-	-	-	ADAMTS2	NM_014244,p.R967C|ENST00000251582,p.R967C|uc003mjw.3,p.R967C	retained_intron, protein_coding	uc003mjw.3	nonsynonymous SNV	exon19	c.C2899T	p.R967C	HAKHCNDARPESRRACSRELCPGRW	HAKHCNDARPESCRACSRELCPGRW	6.0	6.0	-	-	4259_5:178552033-178552033 G>A_HAKHCNDARPESCRACSRELCPGRW	0.0
11:69488012-69488012 G>A	1.0	4287	COLORECTAL	-	-	-	-	ORAOV1	ENST00000441922,p.T43M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000441922	nonsynonymous SNV	exon2	c.C128T	p.T43M	SSLGVMEGRQHGTLHGAKIGSEQKD	SSLGVMEGRQHGMLHGAKIGSEQKD	6.0	9.0	-	-	4287_11:69488012-69488012 G>A_SSLGVMEGRQHGMLHGAKIGSEQKD	0.0
17:47118807-47118807 G>A	1.0	2369	MELANOMA	-	-	-	-	IGF2BP1	ENST00000431824,p.G157R|ENST00000290341,p.G296R|uc002iom.3,p.G296R|NM_006546,p.G296R|uc010dbj.3,p.G157R|NM_001160423,p.G157R	retained_intron, protein_coding, processed_transcript	uc010dbj.3	nonsynonymous SNV	exon6	c.G469A	p.G157R	HNNFVGRLIGKEGRNLKKVEQDTET	HNNFVGRLIGKERRNLKKVEQDTET	5.0	3.0	-	-	2369_17:47118807-47118807 G>A_HNNFVGRLIGKERRNLKKVEQDTET	0.0
8:95444769-95444769 G>A	1.0	3466	MELANOMA	-	-	-	-	FSBP	NM_001256141,p.P164S|uc003ygm.3,p.P164S|ENST00000481490,p.P164S	protein_coding, nonsense_mediated_decay	uc003ygm.3	nonsynonymous SNV	exon2	c.C490T	p.P164S	VEVKQEEDIKPPPPLVLNSQQSDTL	VEVKQEEDIKPPSPLVLNSQQSDTL	7.0	1.0	-	-	3466_8:95444769-95444769 G>A_VEVKQEEDIKPPSPLVLNSQQSDTL	0.0
5:94224595-94224595 G>A	1.0	2369	MELANOMA	-	-	-	-	MCTP1	NM_001002796,p.A420V|ENST00000505078,p.A157V|ENST00000312216,p.A420V|ENST00000429576,p.A374V|ENST00000515393,p.A641V|uc003kku.2,p.A157V|NM_001297777,p.A374V|ENST00000505208,p.A420V|ENST00000508509,p.A361V|uc003kkw.2,p.A374V|uc003kkv.2,p.A420V|uc003kkz.2,p.A302V|uc003kkx.2,p.A641V|NM_024717,p.A641V|ENST00000512425,p.A302V|ENST00000506568,p.A242V	retained_intron, protein_coding, processed_transcript	uc003kkz.2	nonsynonymous SNV	exon11	c.C905T	p.A302V	QVKVIRAEGLMAADVTGKSDPFCVV	QVKVIRAEGLMAVDVTGKSDPFCVV	9.0	10.0	-	-	2369_5:94224595-94224595 G>A_QVKVIRAEGLMAVDVTGKSDPFCVV	0.0
10:15255455-15255455 G>A	1.0	3466	MELANOMA	-	-	-	-	FAM171A1	ENST00000378116,p.S711F|NM_001010924,p.S711F|uc001iob.3,p.S711F	protein_coding, processed_transcript	uc001iob.3	nonsynonymous SNV	exon8	c.C2132T	p.S711F	GKPLPHPRAWFVSLDGRSNAHVRHS	GKPLPHPRAWFVFLDGRSNAHVRHS	8.0	2.0	-	-	3466_10:15255455-15255455 G>A_GKPLPHPRAWFVFLDGRSNAHVRHS	0.0
17:65870945-65870945 A>T	1.0	4258	ENDOMETRIAL	-	-	-	-	BPTF	uc002jge.3,p.E558V|ENST00000544778,p.E558V|uc002jgf.3,p.E558V|ENST00000306378,p.E558V|ENST00000424123,p.E419V|NM_004459,p.E558V|ENST00000321892,p.E558V|NM_182641,p.E558V|uc010wqm.1,p.E558V|ENST00000335221,p.E558V	retained_intron, protein_coding, processed_transcript	uc010wqm.1	nonsynonymous SNV	exon4	c.A1673T	p.E558V	KSFLAAANEEILESIRAKKGDIDNV	KSFLAAANEEILVSIRAKKGDIDNV	10.0	4.0	-	-	4258_17:65870945-65870945 A>T_KSFLAAANEEILVSIRAKKGDIDNV	0.0
X:135825927-135825927 T>A	0.0	4160	COLORECTAL	-	-	-	-	ARHGEF6	ENST00000250617,p.S160C|uc004fab.3,p.S160C|NM_004840,p.S160C	protein_coding	uc004fab.3	nonsynonymous SNV	exon5	c.A478T	p.S160C	RQSKTVEMTENGSHQLIVKARFNFK	RQSKTVEMTENGCHQLIVKARFNFK	5.0	6.0	-	-	4160_X:135825927-135825927 T>A_RQSKTVEMTENGCHQLIVKARFNFK	0.0
17:80333257-80333257 C>T	1.0	4196	COLORECTAL	-	-	-	-	UTS2R	NM_018949,p.R353C|uc010wvl.2,p.R353C|ENST00000313135,p.R353C	protein_coding	uc010wvl.2	nonsynonymous SNV	exon1	c.C1057T	p.R353C	PVPSLQPRARFQRCSGRSLSSCSPQ	PVPSLQPRARFQCCSGRSLSSCSPQ	4.0	9.0	-	-	4196_17:80333257-80333257 C>T_PVPSLQPRARFQCCSGRSLSSCSPQ	0.0
10:63850708-63850708 A>G	1.0	4245	COLORECTAL	-	-	-	-	ARID5B	NM_032199,p.K496E|uc001jlt.2,p.K496E|ENST00000279873,p.K496E|ENST00000309334,p.K253E|uc001jlu.2,p.K253E|NM_001244638,p.K253E	protein_coding	uc001jlu.2	nonsynonymous SNV	exon7	c.A757G	p.K253E	IPEPLPAADMKKKIEGYQEFSAKPL	IPEPLPAADMKKEIEGYQEFSAKPL	8.0	8.0	-	-	4245_10:63850708-63850708 A>G_IPEPLPAADMKKEIEGYQEFSAKPL	0.0
8:22265987-22265987 G>T	1.0	4284	COLORECTAL	-	-	-	-	SLC39A14	ENST00000359741,p.E145D|uc003xbp.4,p.E145D|NM_015359,p.E145D	retained_intron, protein_coding	uc003xbp.4	nonsynonymous SNV	exon3	c.G435T	p.E145D	ENQENEENEQTEEGRPSAVEVWGFG	ENQENEENEQTEDGRPSAVEVWGFG	7.0	8.0	-	-	4284_8:22265987-22265987 G>T_ENQENEENEQTEDGRPSAVEVWGFG	0.0
19:38976336-38976336 G>T	0.0	4240	BREAST	-	-	-	-	RYR1	NM_001042723,p.A1681S|uc002oiu.3,p.A1681S|NM_000540,p.A1681S|uc002oit.3,p.A1681S|ENST00000359596,p.A1681S|ENST00000355481,p.A1681S|ENST00000360985,p.A1681S	retained_intron, protein_coding, nonsense_mediated_decay	uc002oiu.3	nonsynonymous SNV	exon34	c.G5041T	p.A1681S	YRAVCALGNNRVAHALCSHVDQAQL	YRAVCALGNNRVSHALCSHVDQAQL	3.0	8.0	-	-	4240_19:38976336-38976336 G>T_YRAVCALGNNRVSHALCSHVDQAQL	0.0
12:26816658-26816658 C>T	1.0	4196	COLORECTAL	-	-	-	-	ITPR2	NM_002223,p.R558H|ENST00000381340,p.R558H|uc001rhg.3,p.R558H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rhg.3	nonsynonymous SNV	exon15	c.G1673A	p.R558H	YAPYKYMLRLCYRVLRHSQQDYRKN	YAPYKYMLRLCYHVLRHSQQDYRKN	9.0	6.0	-	-	4196_12:26816658-26816658 C>T_YAPYKYMLRLCYHVLRHSQQDYRKN	0.0
1:155006855-155006855 T>A	0.0	4246	COLORECTAL	-	-	-	-	DCST1	uc010per.2,p.N27K|ENST00000525273,p.N27K	retained_intron, protein_coding, nonsense_mediated_decay	uc010per.2	nonsynonymous SNV	exon3	c.T81A	p.N27K	SPASIHLQALNPNEPHPRQKSGLLS	SPASIHLQALNPKEPHPRQKSGLLS	3.0	1.0	-	-	4246_1:155006855-155006855 T>A_SPASIHLQALNPKEPHPRQKSGLLS	0.0
6:110714019-110714019 C>A	1.0	4245	COLORECTAL	-	-	-	-	DDO	ENST00000368923,p.V298F|uc003puc.3,p.V357F|NM_003649,p.V357F|uc003pud.3,p.V298F|ENST00000368924,p.V357F|NM_004032,p.V298F|ENST00000368925,p.V329F	protein_coding, nonsense_mediated_decay	uc003pud.3	nonsynonymous SNV	exon4	c.G892T	p.V298F	TALEAARLVSECVHALRTPIPKSNL	TALEAARLVSECFHALRTPIPKSNL	7.0	6.0	-	-	4245_6:110714019-110714019 C>A_TALEAARLVSECFHALRTPIPKSNL	0.0
3:178936092-178936092 A>G	0.0	4298	COLORECTAL	-	-	ID=COSM125371,COSM764;OCCURENCE=9(skin),13(breast),33(large_intestine),1(eye),5(liver),8(urinary_tract),1(pituitary),8(endometrium),1(lung),2(haematopoietic_and_lymphoid_tissue),3(stomach),4(upper_aerodigestive_tract)	1	PIK3CA	ENST00000263967,p.E545G|uc003fjk.3,p.E545G|NM_006218,p.E545G	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon10	c.A1634G	p.E545G	AISTRDPLSEITEQEKDFLWSHRHY	AISTRDPLSEITGQEKDFLWSHRHY	6.0	2.0	-	-	4298_3:178936092-178936092 A>G_AISTRDPLSEITGQEKDFLWSHRHY	0.0
6:74135166-74135166 T>G	0.0	4345	COLORECTAL	-	-	-	-	MB21D1	NM_138441,p.Q451H|uc003pgx.1,p.Q451H|ENST00000370315,p.Q451H	retained_intron, protein_coding	uc003pgx.1	nonsynonymous SNV	exon5	c.A1353C	p.Q451H	KTAFFHVCTQNPQDSQWDRKDLGLC	KTAFFHVCTQNPHDSQWDRKDLGLC	5.0	5.0	-	-	4345_6:74135166-74135166 T>G_KTAFFHVCTQNPHDSQWDRKDLGLC	0.0
5:163011-163011 G>A	0.0	3795	MELANOMA	-	-	-	-	PLEKHG4B	NM_052909,p.D586N|ENST00000283426,p.D586N|uc003jak.2,p.D586N	retained_intron, protein_coding	uc003jak.2	nonsynonymous SNV	exon11	c.G1756A	p.D586N	PHALGKPWASQQDLWLQYPQTRLRL	PHALGKPWASQQNLWLQYPQTRLRL	3.0	2.0	-	-	3795_5:163011-163011 G>A_PHALGKPWASQQNLWLQYPQTRLRL	0.0
4:187628644-187628644 G>A	0.0	3795	MELANOMA	-	-	-	1	FAT1	uc003izf.3,p.L780F|NM_005245,p.L780F|ENST00000441802,p.L780F|uc010iso.1,p.L780F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010iso.1	nonsynonymous SNV	exon2	c.C2338T	p.L780F	DMETGMLKILSPLDRETTDKYTLNI	DMETGMLKILSPFDRETTDKYTLNI	8.0	10.0	-	-	3795_4:187628644-187628644 G>A_DMETGMLKILSPFDRETTDKYTLNI	0.0
5:93788673-93788673 G>A	0.0	4335	COLORECTAL	-	-	-	-	KIAA0825	ENST00000513200,p.S783F|uc011cuk.2,p.S783F|ENST00000312498,p.S783F|NM_001145678,p.S783F|ENST00000427991,p.S783F	retained_intron, protein_coding, processed_transcript	uc011cuk.2	nonsynonymous SNV	exon13	c.C2348T	p.S783F	LYWVSCISHFYPSLLRTPSAGGLKA	LYWVSCISHFYPFLLRTPSAGGLKA	5.0	2.0	-	-	4335_5:93788673-93788673 G>A_LYWVSCISHFYPFLLRTPSAGGLKA	0.0
11:118453994-118453994 A>C	0.0	4345	COLORECTAL	-	-	-	-	ARCN1	ENST00000359415,p.E164A|ENST00000264028,p.E123A|uc010ryg.2,p.E35A|uc001ptq.3,p.E123A|NM_001655,p.E123A|NM_001142281,p.E35A|ENST00000392859,p.E35A|uc009zag.3,p.E164A	protein_coding, processed_transcript	uc010ryg.2	nonsynonymous SNV	exon2	c.A104C	p.E35A	FAFDEIVALGYRENVNLAQIRTFTE	FAFDEIVALGYRANVNLAQIRTFTE	9.0	3.0	-	-	4345_11:118453994-118453994 A>C_FAFDEIVALGYRANVNLAQIRTFTE	0.0
1:20827673-20827673 T>-	1.0	4326	BREAST	-	-	-	-	MUL1	ENST00000264198,p.K190fs|uc001bdi.4,p.K190fs|NM_024544,p.K190fs	protein_coding	uc001bdi.4	frameshift deletion	exon4	c.569delA	p.K190fs	RPKGIQETEEMLKVGATLTGVGELVL	RPKGIQETEEMLRWGPPSQGLANWSWTTTLSACSRPNKACSTI	6.0	8.0	-	-	4326_1:20827673-20827673 T>-_RPKGIQETEEMLRWGPPSQGLANWSWTTTLSACSRPNKACSTI	0.0
9:37801045-37801045 C>T	1.0	4240	BREAST	-	-	-	-	DCAF10	uc004aao.3,p.S61L|ENST00000242323,p.S61L|NM_024345,p.S61L|ENST00000377724,p.S61L	protein_coding, processed_transcript	uc004aao.3	nonsynonymous SNV	exon1	c.C182T	p.S61L	PPARSPRRPGAPSLSPAPRSGELGL	PPARSPRRPGAPLLSPAPRSGELGL	9.0	9.0	-	-	4240_9:37801045-37801045 C>T_PPARSPRRPGAPLLSPAPRSGELGL	0.0
1:182356337-182356337 C>T	1.0	4298	COLORECTAL	0.0005	-	-	-	GLUL	NM_002065,p.R86Q|NM_001033056,p.R86Q|ENST00000331872,p.R86Q|uc001gpc.2,p.R86Q|uc001gpd.2,p.R86Q|ENST00000311223,p.R86Q|NM_001033044,p.R86Q|ENST00000417584,p.R86Q|uc001gpb.2,p.R86Q|uc001gpa.2,p.R86Q|ENST00000339526,p.R86Q	protein_coding, processed_transcript	uc001gpd.2	nonsynonymous SNV	exon3	c.G257A	p.R86Q	NSDMYLVPAAMFRDPFRKDPNKLVL	NSDMYLVPAAMFQDPFRKDPNKLVL	10.0	8.0	-	-	4298_1:182356337-182356337 C>T_NSDMYLVPAAMFQDPFRKDPNKLVL	0.0
20:18037360-18037360 C>G	0.0	3775	CERVICAL	-	-	-	-	OVOL2	NM_021220,p.E88Q|ENST00000278780,p.E88Q|uc002wqi.1,p.E88Q	protein_coding, processed_transcript	uc002wqi.1	nonsynonymous SNV	exon2	c.G262C	p.E88Q	APESETPEPGDAEGPDGHLATKQRP	APESETPEPGDAQGPDGHLATKQRP	4.0	5.0	-	-	3775_20:18037360-18037360 C>G_APESETPEPGDAQGPDGHLATKQRP	0.0
9:77390974-77390974 C>T	0.0	2556	MELANOMA	-	-	-	-	TRPM6	uc004ajj.1,p.M32I	protein_coding, processed_transcript	uc004ajj.1	nonsynonymous SNV	exon1	c.G96A	p.M32I	SLTSSYSNVYLDMESISNNLWKYNR	SLTSSYSNVYLDIESISNNLWKYNR	1.0	5.0	-	-	2556_9:77390974-77390974 C>T_SLTSSYSNVYLDIESISNNLWKYNR	0.0
6:84930778-84930778 C>T	0.0	4240	BREAST	-	-	ID=COSM744013;OCCURENCE=1(lung)	-	CEP162	uc003pkk.2,p.D57N|NM_014895,p.D57N|ENST00000403245,p.D57N|uc010kbp.3,p.D57N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kbp.3	nonsynonymous SNV	exon3	c.G169A	p.D57N	VPWWITEDDFKDDGLLGTNVSYLKT	VPWWITEDDFKDNGLLGTNVSYLKT	7.0	9.0	-	-	4240_6:84930778-84930778 C>T_VPWWITEDDFKDNGLLGTNVSYLKT	0.0
16:88876532-88876532 C>T	1.0	4259	COLORECTAL	0.0005	-	-	-	APRT	ENST00000563655,p.A89T	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000563655	nonsynonymous SNV	exon3	c.G265A	p.A89T	RAPRAELEIQKDALEPGQRVVVVDD	RAPRAELEIQKDTLEPGQRVVVVDD	10.0	7.0	-	-	4259_16:88876532-88876532 C>T_RAPRAELEIQKDTLEPGQRVVVVDD	0.0
1:171526655-171526655 C>T	1.0	4000	MELANOMA	-	-	-	-	PRRC2C	ENST00000338920,p.P1800S|ENST00000392078,p.P1802S|ENST00000367742,p.P1802S|uc010pmg.2,p.P1800S|ENST00000426496,p.P1800S|uc010pmh.2,p.P777S|NM_015172,p.P1800S	retained_intron, protein_coding, processed_transcript	uc010pmh.2	nonsynonymous SNV	exon4	c.C2329T	p.P777S	STLAPVLASTSAPVPASPLAPVSAS	STLAPVLASTSASVPASPLAPVSAS	10.0	8.0	-	-	4000_1:171526655-171526655 C>T_STLAPVLASTSASVPASPLAPVSAS	0.0
6:43305003-43305003 G>A	1.0	2591	MELANOMA	-	-	-	-	ZNF318	uc003oux.3,p.P2245S|NM_014345,p.P2245S|ENST00000361428,p.P2245S	protein_coding	uc003oux.3	nonsynonymous SNV	exon10	c.C6733T	p.P2245S	LNLVKAPVSRSPPREQVIEDNMVPQ	LNLVKAPVSRSPSREQVIEDNMVPQ	6.0	10.0	-	-	2591_6:43305003-43305003 G>A_LNLVKAPVSRSPSREQVIEDNMVPQ	0.0
19:12951264-12951264 C>G	1.0	4326	BREAST	-	-	-	-	MAST1	ENST00000251472,p.R30G|uc002mvm.3,p.R30G|NM_014975,p.R30G	retained_intron, protein_coding	uc002mvm.3	nonsynonymous SNV	exon2	c.C88G	p.R30G	PGGSMFRRTKSCRTSNRKSLILTST	PGGSMFRRTKSCGTSNRKSLILTST	6.0	8.0	-	-	4326_19:12951264-12951264 C>G_PGGSMFRRTKSCGTSNRKSLILTST	0.0
7:6426892-6426892 C>T	1.0	3919	MELANOMA	-	-	ID=COSM1167878,COSM125734;OCCURENCE=3(NS),1(upper_aerodigestive_tract),1(breast),38(skin),1(endometrium)	1	RAC1	uc003spx.3,p.P29S|NM_006908,p.P29S|uc003spw.3,p.P29S|ENST00000356142,p.P29S|ENST00000348035,p.P29S|NM_018890,p.P29S	retained_intron, protein_coding, processed_transcript	uc003spx.3	nonsynonymous SNV	exon2	c.C85T	p.P29S	TCLLISYTTNAFPGEYIPTVFDNYS	TCLLISYTTNAFSGEYIPTVFDNYS	10.0	6.0	-	-	3919_7:6426892-6426892 C>T_TCLLISYTTNAFSGEYIPTVFDNYS	0.0
6:133005539-133005539 C>T	1.0	4252	COLORECTAL	-	-	-	-	VNN1	NM_004666,p.G432R|ENST00000367928,p.G432R|uc003qdo.3,p.G432R	protein_coding	uc003qdo.3	nonsynonymous SNV	exon6	c.G1294A	p.G432R	TRFEMFSLSGTFGTQYVFPEVLLSE	TRFEMFSLSGTFRTQYVFPEVLLSE	4.0	7.0	-	-	4252_6:133005539-133005539 C>T_TRFEMFSLSGTFRTQYVFPEVLLSE	0.0
1:52520755-52520755 G>A	1.0	3713	MELANOMA	-	-	-	-	TXNDC12	NM_015913,p.P5L|ENST00000371626,p.P5L|uc001cti.4,p.P5L	protein_coding, processed_transcript	uc001cti.4	nonsynonymous SNV	exon1	c.C14T	p.P5L	METRPRLGATCLLGFSF	METRLRLGATCLLGFSF	9.0	7.0	-	-	3713_1:52520755-52520755 G>A_METRLRLGATCLLGFSF	0.0
22:42189882-42189882 T>A	0.0	4345	COLORECTAL	-	-	-	-	MEI1	uc011apf.1,p.L146H	retained_intron, protein_coding, processed_transcript	uc011apf.1	nonsynonymous SNV	exon4	c.T437A	p.L146H	LSQACVGCLEALLDYLDARSPDIGR	LSQACVGCLEALHDYLDARSPDIGR	4.0	2.0	-	-	4345_22:42189882-42189882 T>A_LSQACVGCLEALHDYLDARSPDIGR	0.0
11:16800564-16800564 T>A	0.0	4077	BILE DUCT	-	-	-	-	C11orf58,PLEKHA7	uc010rcu.1,p.Q1267L|ENST00000531066,p.Q1266L	retained_intron, protein_coding, processed_transcript	uc010rcu.1	nonsynonymous SNV	exon27	c.A3800T	p.Q1267L	SEASQRSKQVAAQAVTDP	SEASQRSKQVAALAVTDP	8.0	8.0	-	-	4077_11:16800564-16800564 T>A_SEASQRSKQVAALAVTDP	0.0
5:38958823-38958823 G>C	0.0	4335	COLORECTAL	-	-	-	-	RICTOR	uc010ivf.2,p.N478K|ENST00000357387,p.N763K|ENST00000296782,p.N763K|uc003jlp.2,p.N763K|NM_001285439,p.N763K|NM_152756,p.N763K|uc003jlo.2,p.N763K|NM_001285440,p.N478K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ivf.2	nonsynonymous SNV	exon23	c.C1434G	p.N478K	GIELLVTQLHDKNKTISSEALDILD	GIELLVTQLHDKKKTISSEALDILD	9.0	5.0	-	-	4335_5:38958823-38958823 G>C_GIELLVTQLHDKKKTISSEALDILD	0.0
19:16000397-16000397 C>T	0.0	3903	MELANOMA	-	-	-	-	CYP4F2	uc002nbs.1,p.D252N|uc010xot.1,p.D103N|NM_001082,p.D252N|ENST00000221700,p.D252N|ENST00000011989,p.D103N|ENST00000592328,p.D252N|uc010xou.1,p.D103N	retained_intron, protein_coding, nonsense_mediated_decay	uc010xou.1	nonsynonymous SNV	exon6	c.G307A	p.D103N	LLHIDFLYYLTPDGQRFRRACRLVH	LLHIDFLYYLTPNGQRFRRACRLVH	3.0	2.0	-	-	3903_19:16000397-16000397 C>T_LLHIDFLYYLTPNGQRFRRACRLVH	0.0
7:100641888-100641888 G>A	0.0	4110	BILE DUCT	-	-	-	-	MUC12	ENST00000536621,p.V2682I|NM_001164462,p.V2682I|uc003uxo.3,p.V2682I|ENST00000379442,p.V2825I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uxo.3	nonsynonymous SNV	exon2	c.G8044A	p.V2682I	TTLSPASMTSLGVGEESTTSRSQPG	TTLSPASMTSLGIGEESTTSRSQPG	6.0	6.0	-	-	4110_7:100641888-100641888 G>A_TTLSPASMTSLGIGEESTTSRSQPG	0.0
6:73830278-73830278 T>G	0.0	4213	COLORECTAL	-	-	-	-	KCNQ5	ENST00000355635,p.L400V	protein_coding	ENST00000355635	nonsynonymous SNV	exon8	c.T1198G	p.L400V	VSIATWKPHLKALHTCSPTKQNQQG	VSIATWKPHLKAVHTCSPTKQNQQG	4.0	4.0	-	-	4213_6:73830278-73830278 T>G_VSIATWKPHLKAVHTCSPTKQNQQG	0.0
X:105450417-105450417 C>T	0.0	3775	CERVICAL	-	-	-	-	MUM1L1	uc004emf.2,p.S331L|uc004emg.2,p.S331L|NM_001171020,p.S331L|ENST00000357175,p.S331L|ENST00000337685,p.S331L|ENST00000372552,p.S331L|uc022cca.1,p.S331L|NM_152423,p.S331L	protein_coding	uc022cca.1	nonsynonymous SNV	exon1	c.C992T	p.S331L	VSFSASNPVWDYSHLMSSERNFQRL	VSFSASNPVWDYLHLMSSERNFQRL	1.0	7.0	-	-	3775_X:105450417-105450417 C>T_VSFSASNPVWDYLHLMSSERNFQRL	0.0
12:6690213-6690213 T>G	1.0	3466	MELANOMA	-	-	-	1	CHD4	uc001qpo.3,p.K1636Q|ENST00000544040,p.K1629Q|NM_001297553,p.K1629Q|ENST00000357008,p.K1636Q|uc001qpp.3,p.K1661Q|ENST00000309577,p.K1664Q|ENST00000544484,p.K1661Q|NM_001273,p.K1636Q|uc001qpn.3,p.K1629Q	retained_intron, protein_coding, processed_transcript	uc001qpp.3	nonsynonymous SNV	exon32	c.A4981C	p.K1661Q	KERTEEPMETEPKGAADVEKVEEKS	KERTEEPMETEPQGAADVEKVEEKS	10.0	4.0	-	-	3466_12:6690213-6690213 T>G_KERTEEPMETEPQGAADVEKVEEKS	0.0
7:905618-905618 G>A	1.0	4266	COLORECTAL	-	-	-	-	SUN1	ENST00000425407,p.E549K|NM_025154,p.E549K|ENST00000456758,p.E821K|uc021zym.1,p.E632K|uc003sjk.3,p.E271K|uc003sji.3,p.E470K|ENST00000389574,p.E549K|uc003sjg.3,p.E537K|ENST00000413514,p.E430K|uc011jvr.2,p.E430K|NM_001130965,p.E632K|ENST00000429178,p.E557K|uc011jvq.2,p.E529K|ENST00000405266,p.E669K|uc003sjf.3,p.E549K|ENST00000401592,p.E632K|NM_001171944,p.E529K|ENST00000452783,p.E529K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zym.1	nonsynonymous SNV	exon16	c.G1894A	p.E632K	SGGGSILSTRCSETYETKTALMSLF	SGGGSILSTRCSKTYETKTALMSLF	10.0	9.0	-	-	4266_7:905618-905618 G>A_SGGGSILSTRCSKTYETKTALMSLF	0.0
2:108487278-108487278 C>T	0.0	3919	MELANOMA	-	-	-	-	RGPD4	NM_182588,p.P940S|uc010ywk.2,p.P940S|ENST00000408999,p.P940S|ENST00000354986,p.P940S|uc002tdu.3,p.P127S	protein_coding	uc010ywk.2	nonsynonymous SNV	exon20	c.C2818T	p.P940S	SEPGNQEKESEKPLENDTGFQAQDI	SEPGNQEKESEKSLENDTGFQAQDI	2.0	8.0	-	-	3919_2:108487278-108487278 C>T_SEPGNQEKESEKSLENDTGFQAQDI	0.0
20:34807689-34807689 G>A	1.0	4155	MELANOMA	-	-	-	-	EPB41L1	uc002xfb.3,p.G788R|ENST00000373941,p.G787R|uc002xew.3,p.G679R|uc002xeu.3,p.G686R|NM_012156,p.G788R|NM_001258330,p.G608R|NM_177996,p.G686R|uc002xey.3,p.G538R|ENST00000338074,p.G788R|ENST00000373946,p.G608R|NM_001258329,p.G787R|ENST00000454226,p.G149R|uc002xex.3,p.G608R|uc002xez.4,p.G686R|ENST00000373950,p.G679R|uc002xev.3,p.G787R|ENST00000202028,p.G686R|NM_001258331,p.G686R|ENST00000441639,p.G686R|uc010gfq.3,p.G886R	protein_coding, processed_transcript	uc010gfq.3	nonsynonymous SNV	exon9	c.G2656A	p.G886R	VATEIRSLSPIIGKDVLTSTYGATA	VATEIRSLSPIIRKDVLTSTYGATA	7.0	8.0	-	-	4155_20:34807689-34807689 G>A_VATEIRSLSPIIRKDVLTSTYGATA	0.0
X:123515092-123515092 G>A	0.0	4301	MELANOMA	-	-	-	-	TENM1	NM_001163278,p.S2498F|uc011muj.2,p.S2497F|ENST00000371130,p.S2491F|uc010nqy.3,p.S2498F|NM_014253,p.S2491F|uc004euj.3,p.S2491F|NM_001163279,p.S2497F|ENST00000422452,p.S2498F	protein_coding, processed_transcript	uc011muj.2	nonsynonymous SNV	exon32	c.C7490T	p.S2497F	QCELQKQLRNFISLDQLPMTPRYND	QCELQKQLRNFIFLDQLPMTPRYND	4.0	6.0	-	-	4301_X:123515092-123515092 G>A_QCELQKQLRNFIFLDQLPMTPRYND	0.0
1:151491225-151491225 C>T	1.0	4000	MELANOMA	-	-	-	-	CGN	ENST00000427934,p.S77F|NM_020770,p.S77F|ENST00000502442,p.S77F|ENST00000505188,p.S77F|ENST00000271636,p.S77F|uc009wmw.3,p.S77F	retained_intron, protein_coding	uc009wmw.3	nonsynonymous SNV	exon2	c.C230T	p.S77F	FVVLNSGEKGGDSFGVQIKGANDQG	FVVLNSGEKGGDFFGVQIKGANDQG	6.0	7.0	-	-	4000_1:151491225-151491225 C>T_FVVLNSGEKGGDFFGVQIKGANDQG	0.0
1:52959328-52959328 G>A	1.0	3466	MELANOMA	-	-	-	-	ZCCHC11	NM_001009881,p.H425Y|NM_015269,p.H425Y|ENST00000257177,p.H425Y|uc001cty.2,p.H425Y|uc009vzf.1,p.H184Y|uc009vze.1,p.H425Y|uc001ctx.2,p.H425Y|uc001cub.3,p.H425Y|ENST00000484723,p.H184Y|ENST00000371544,p.H425Y|ENST00000528642,p.H425Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009vzf.1	nonsynonymous SNV	exon7	c.C550T	p.H184Y	VNIDIKFPPKMNHPDLLIKVLGILK	VNIDIKFPPKMNYPDLLIKVLGILK	9.0	7.0	-	-	3466_1:52959328-52959328 G>A_VNIDIKFPPKMNYPDLLIKVLGILK	0.0
7:78636436-78636436 G>A	1.0	3879	MELANOMA	-	-	ID=COSM1214267;OCCURENCE=1(large_intestine)	-	MAGI2	NM_012301,p.R130C|ENST00000419488,p.R130C|uc003ugx.3,p.R130C|NM_001301128,p.R130C|uc003ugy.3,p.R130C|ENST00000354212,p.R130C|ENST00000522391,p.R130C	retained_intron, protein_coding, processed_transcript	uc003ugy.3	nonsynonymous SNV	exon2	c.C388T	p.R130C	KGSVDHELQQIIRDNLYLRTVPCTT	KGSVDHELQQIICDNLYLRTVPCTT	5.0	3.0	-	-	3879_7:78636436-78636436 G>A_KGSVDHELQQIICDNLYLRTVPCTT	0.0
17:39388922-39388922 T>A	0.0	4266	COLORECTAL	-	-	-	-	KRTAP9-3	uc021txg.1,p.C57S|NM_031962,p.C57S|ENST00000411528,p.C57S	protein_coding	uc021txg.1	nonsynonymous SNV	exon1	c.T169A	p.C57S	PCCHPTCCQNTCCRTTCCQPICVTS	PCCHPTCCQNTCSRTTCCQPICVTS	1.0	6.0	-	-	4266_17:39388922-39388922 T>A_PCCHPTCCQNTCSRTTCCQPICVTS	0.0
15:57745949-57745949 C>T	1.0	4326	BREAST	-	-	-	-	CGNL1	ENST00000281282,p.S708L|NM_001252335,p.S708L|uc010bfw.3,p.S708L|uc002aeg.3,p.S708L|NM_032866,p.S708L	protein_coding, processed_transcript	uc010bfw.3	nonsynonymous SNV	exon8	c.C2123T	p.S708L	HQTEIRDLQDQLSEMHDELDSAKRS	HQTEIRDLQDQLLEMHDELDSAKRS	6.0	4.0	-	-	4326_15:57745949-57745949 C>T_HQTEIRDLQDQLLEMHDELDSAKRS	0.0
6:112400838-112400838 C>T	1.0	3879	MELANOMA	-	-	-	-	TUBE1	NM_016262,p.G149E|ENST00000368662,p.G149E|ENST00000605457,p.G149E|uc003pvq.3,p.G149E	protein_coding	uc003pvq.3	nonsynonymous SNV	exon6	c.G446A	p.G149E	CLQCFFIIHSMGGGTGSGLGTFLLK	CLQCFFIIHSMGEGTGSGLGTFLLK	8.0	7.0	-	-	3879_6:112400838-112400838 C>T_CLQCFFIIHSMGEGTGSGLGTFLLK	0.0
10:70056023-70056023 T>G	1.0	4345	COLORECTAL	-	-	-	-	PBLD	uc001jns.1,p.K95Q|uc001jnu.1,p.K95Q|uc001jnt.1,p.K95Q|NM_022129,p.K95Q|ENST00000309049,p.K95Q|ENST00000336578,p.K62Q|NM_001033083,p.K95Q|ENST00000358769,p.K95Q|ENST00000432941,p.K95Q|uc001jnr.1,p.K62Q	protein_coding, processed_transcript	uc001jnu.1	nonsynonymous SNV	exon4	c.A283C	p.K95Q	TLASAAVLFHKIKNMNSTLTFVTLS	TLASAAVLFHKIQNMNSTLTFVTLS	6.0	3.0	-	-	4345_10:70056023-70056023 T>G_TLASAAVLFHKIQNMNSTLTFVTLS	0.0
10:5978529-5978529 G>A	1.0	4345	COLORECTAL	-	-	-	-	FBXO18	ENST00000379999,p.M1031I|uc001iit.4,p.M1031I|uc001iir.4,p.M923I|NM_001258452,p.M923I|NM_178150,p.M980I|NM_032807,p.M1031I|ENST00000397269,p.M484I|ENST00000362091,p.M980I|uc001iis.4,p.M980I|uc009xig.4,p.M906I|NM_001258453,p.M906I	protein_coding, processed_transcript	uc009xig.4	nonsynonymous SNV	exon21	c.G2718A	p.M906I	CNNAIPVDTVLTMKKLPITYSNRKE	CNNAIPVDTVLTIKKLPITYSNRKE	7.0	1.0	-	-	4345_10:5978529-5978529 G>A_CNNAIPVDTVLTIKKLPITYSNRKE	0.0
5:11117597-11117597 G>C	0.0	4284	COLORECTAL	-	-	-	2	CTNND2	uc011cmz.1,p.Q315E|ENST00000359640,p.Q748E|NM_001288717,p.Q315E|NM_001288715,p.Q657E|ENST00000304623,p.Q748E|ENST00000511377,p.Q657E|uc011cmx.1,p.Q315E|ENST00000503622,p.Q411E|ENST00000458100,p.Q315E|uc010itt.2,p.Q657E|uc003jfa.1,p.Q748E|ENST00000513588,p.Q502E|NM_001332,p.Q748E|NM_001288716,p.Q411E|uc011cmy.1,p.Q411E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cmz.1	nonsynonymous SNV	exon12	c.C943G	p.Q315E	CDGLTDALLYVIQSALGSSEIDSKT	CDGLTDALLYVIESALGSSEIDSKT	3.0	2.0	-	-	4284_5:11117597-11117597 G>C_CDGLTDALLYVIESALGSSEIDSKT	0.0
10:91497836-91497836 G>A	1.0	4189	MELANOMA	-	-	-	-	KIF20B	ENST00000371728,p.E1080K|uc001kgt.1,p.E291K|uc001kgs.1,p.E1080K|ENST00000416354,p.E1110K|NM_016195,p.E1040K|ENST00000394289,p.E1080K|ENST00000260753,p.E1040K|uc001kgr.1,p.E1040K|NM_001284259,p.E1080K	protein_coding, processed_transcript	uc001kgt.1	nonsynonymous SNV	exon7	c.G871A	p.E291K	VKASSKKSHQIEELEQQIEKLQAEV	VKASSKKSHQIEKLEQQIEKLQAEV	7.0	9.0	-	-	4189_10:91497836-91497836 G>A_VKASSKKSHQIEKLEQQIEKLQAEV	0.0
10:121436513-121436513 G>T	1.0	4234	NSCLC	-	-	-	-	BAG3	uc001lel.3,p.G482C|uc001lem.3,p.G483C|NM_004281,p.G483C|ENST00000369085,p.G483C	protein_coding	uc001lem.3	nonsynonymous SNV	exon4	c.G1447T	p.G483C	EGRADVRQARRDGVRKVQTILEKLE	EGRADVRQARRDCVRKVQTILEKLE	8.0	10.0	-	-	4234_10:121436513-121436513 G>T_EGRADVRQARRDCVRKVQTILEKLE	0.0
5:122361558-122361558 G>A	1.0	3713	MELANOMA	-	-	-	-	PPIC	ENST00000306442,p.S144F|uc003kth.3,p.S144F|NM_000943,p.S144F	retained_intron, protein_coding	uc003kth.3	nonsynonymous SNV	exon4	c.C431T	p.S144F	VSMANAGPDTNGSQFFITLTKPTWL	VSMANAGPDTNGFQFFITLTKPTWL	2.0	8.0	-	-	3713_5:122361558-122361558 G>A_VSMANAGPDTNGFQFFITLTKPTWL	0.0
8:32621289-32621289 C>A	0.0	4284	COLORECTAL	-	-	-	1	NRG1	ENST00000356819,p.P436Q|uc011lbh.1,p.P274Q|uc003xja.2,p.P242Q|ENST00000518104,p.P398Q|uc003xiw.2,p.P428Q|ENST00000287845,p.P402Q|ENST00000405005,p.P431Q|uc010lvr.2,p.P173Q|ENST00000523534,p.P504Q|ENST00000287842,p.P428Q|NM_013956,p.P436Q|NM_013957,p.P428Q|ENST00000338921,p.P439Q|uc010lvs.2,p.P173Q|NM_013964,p.P431Q|uc003xiv.2,p.P431Q|ENST00000287840,p.P431Q|ENST00000519301,p.P381Q|uc003xiu.2,p.P436Q|uc022ats.1,p.P381Q|ENST00000539990,p.P274Q	retained_intron, protein_coding, processed_transcript	uc022ats.1	nonsynonymous SNV	exon11	c.C1142A	p.P381Q	PHSERYVSAMTTPARMSPVDFHTPS	PHSERYVSAMTTQARMSPVDFHTPS	5.0	7.0	-	-	4284_8:32621289-32621289 C>A_PHSERYVSAMTTQARMSPVDFHTPS	0.0
1:67306327-67306327 A>C	1.0	4244	COLORECTAL	-	-	-	-	WDR78	ENST00000464352,p.V206G|ENST00000371026,p.V440G|ENST00000371023,p.V440G|NM_207014,p.V440G|uc001dcy.3,p.V440G|NM_024763,p.V440G|uc001dcx.3,p.V440G|uc009waw.3,p.V186G|ENST00000431318,p.V186G	protein_coding, processed_transcript, nonsense_mediated_decay	uc009waw.3	nonsynonymous SNV	exon5	c.T557G	p.V186G	VLKEPEPEEPEDVLESAKHEEVEEE	VLKEPEPEEPEDGLESAKHEEVEEE	6.0	5.0	-	-	4244_1:67306327-67306327 A>C_VLKEPEPEEPEDGLESAKHEEVEEE	0.0
X:73740836-73740836 G>A	1.0	2556	MELANOMA	-	-	-	-	SLC16A2	ENST00000587091,p.A148T|uc031tjy.1,p.A148T|NM_006517,p.A148T|ENST00000276033,p.A222T	protein_coding	uc031tjy.1	nonsynonymous SNV	exon2	c.G442A	p.A148T	NRQVEFQAAWVGALAMGMIFFCSPI	NRQVEFQAAWVGTLAMGMIFFCSPI	5.0	4.0	-	-	2556_X:73740836-73740836 G>A_NRQVEFQAAWVGTLAMGMIFFCSPI	0.0
3:142521182-142521182 C>T	1.0	3919	MELANOMA	-	-	-	-	TRPC1	uc003evb.3,p.H551Y|ENST00000476941,p.H585Y|NM_003304,p.H551Y|NM_001251845,p.H585Y|ENST00000273482,p.H551Y|uc003evc.3,p.H585Y|uc011bni.1,p.H104Y	retained_intron, protein_coding, nonsense_mediated_decay	uc011bni.1	nonsynonymous SNV	exon2	c.C310T	p.H104Y	GIFCEQQSNDTFHSFIGTCFALFWY	GIFCEQQSNDTFYSFIGTCFALFWY	4.0	4.0	-	-	3919_3:142521182-142521182 C>T_GIFCEQQSNDTFYSFIGTCFALFWY	0.0
1:176563999-176563999 G>T	0.0	4129	NSCLC	-	-	-	-	PAPPA2	uc001gky.1,p.R420L|NM_021936,p.R420L|NM_020318,p.R420L|ENST00000367662,p.R420L|ENST00000367661,p.R420L|uc001gkz.3,p.R420L	protein_coding, processed_transcript	uc001gkz.3	nonsynonymous SNV	exon3	c.G1259T	p.R420L	LGGDSSEDGHYFRGHLGTLVFWSTA	LGGDSSEDGHYFLGHLGTLVFWSTA	1.0	1.0	-	-	4129_1:176563999-176563999 G>T_LGGDSSEDGHYFLGHLGTLVFWSTA	0.0
13:92345698-92345698 C>T	0.0	4316	COLORECTAL	-	-	-	-	GPC5	uc010tif.2,p.R195W|ENST00000377067,p.R195W|NM_004466,p.R195W	protein_coding, processed_transcript	uc010tif.2	nonsynonymous SNV	exon3	c.C583T	p.R195W	VTDSSLEYSECIRMARRDVSPFGNI	VTDSSLEYSECIWMARRDVSPFGNI	3.0	9.0	-	-	4316_13:92345698-92345698 C>T_VTDSSLEYSECIWMARRDVSPFGNI	0.0
10:30654175-30654175 G>A	0.0	4189	MELANOMA	-	-	-	-	GOLGA2P6	ENST00000358107,p.L30F|uc001ivb.4,p.L30F	protein_coding, processed_transcript	uc001ivb.4	nonsynonymous SNV	exon8	c.C88T	p.L30F	SRCDPIILDPEWLYGPPEGEGGPEG	SRCDPIILDPEWFYGPPEGEGGPEG	7.0	8.0	-	-	4189_10:30654175-30654175 G>A_SRCDPIILDPEWFYGPPEGEGGPEG	0.0
12:85518095-85518095 G>A	0.0	3903	MELANOMA	-	-	-	-	LRRIQ1	ENST00000393217,p.D1269N|uc021rbo.1,p.D1147N|uc001tac.3,p.D1269N|NM_001079910,p.D1269N	retained_intron, protein_coding, nonsense_mediated_decay	uc021rbo.1	nonsynonymous SNV	exon13	c.G3439A	p.D1147N	EPDSPDIPEKWMDSVSSHSPLSKSA	EPDSPDIPEKWMNSVSSHSPLSKSA	3.0	2.0	-	-	3903_12:85518095-85518095 G>A_EPDSPDIPEKWMNSVSSHSPLSKSA	0.0
4:44690143-44690143 C>T	1.0	4281	COLORECTAL	-	-	-	-	GUF1	ENST00000281543,p.A353V|uc003gww.4,p.A353V|NM_021927,p.A353V	protein_coding, processed_transcript, nonsense_mediated_decay	uc003gww.4	nonsynonymous SNV	exon9	c.C1058T	p.A353V	KQPVEPLPGFKSAKPMVFAGMYPLD	KQPVEPLPGFKSVKPMVFAGMYPLD	7.0	5.0	-	-	4281_4:44690143-44690143 C>T_KQPVEPLPGFKSVKPMVFAGMYPLD	0.0
11:45907463-45907463 C>T	0.0	4189	MELANOMA	-	-	-	-	MAPK8IP1	uc001nbr.3,p.P31L|ENST00000241014,p.P31L|NM_005456,p.P31L	retained_intron, protein_coding, processed_transcript	uc001nbr.3	nonsynonymous SNV	exon1	c.C92T	p.P31L	ASPFLGLHIASPPNFRLTHDISLEE	ASPFLGLHIASPLNFRLTHDISLEE	5.0	7.0	-	-	4189_11:45907463-45907463 C>T_ASPFLGLHIASPLNFRLTHDISLEE	0.0
2:85769048-85769048 C>G	1.0	4326	BREAST	-	-	-	-	MAT2A	uc002spr.3,p.R168G|ENST00000409017,p.R105G|NM_005911,p.R168G|uc010ysr.2,p.R168G|ENST00000306434,p.R168G|uc010fgl.2,p.R105G	retained_intron, protein_coding, processed_transcript	uc010ysr.2	nonsynonymous SNV	exon5	c.C502G	p.R168G	LAHKLNAKLAELRRNGTLPWLRPDS	LAHKLNAKLAELGRNGTLPWLRPDS	10.0	5.0	-	-	4326_2:85769048-85769048 C>G_LAHKLNAKLAELGRNGTLPWLRPDS	0.0
7:94056954-94056954 C>T	0.0	4320	COLORECTAL	-	-	-	-	COL1A2	uc003ung.1,p.P1095S|ENST00000297268,p.P1095S|NM_000089,p.P1095S	retained_intron, protein_coding	uc003ung.1	nonsynonymous SNV	exon49	c.C3283T	p.P1095S	QGHQGPAGPPGPPGPPGPPGVSGGG	QGHQGPAGPPGPSGPPGPPGVSGGG	10.0	8.0	-	-	4320_7:94056954-94056954 C>T_QGHQGPAGPPGPSGPPGPPGVSGGG	0.0
4:77662468-77662468 C>T	1.0	4284	COLORECTAL	-	-	-	-	SHROOM3	uc011cbx.2,p.R1048C|uc011cbz.1,p.R872C|uc003hkg.3,p.R826C|NM_020859,p.R1048C|ENST00000296043,p.R1048C|uc003hkf.1,p.R923C	retained_intron, protein_coding, processed_transcript	uc011cbz.1	nonsynonymous SNV	exon4	c.C2614T	p.R872C	EPAPLGPQRNGMRFPESSVADRRRL	EPAPLGPQRNGMCFPESSVADRRRL	9.0	8.0	-	-	4284_4:77662468-77662468 C>T_EPAPLGPQRNGMCFPESSVADRRRL	0.0
5:90052931-90052931 G>A	0.0	2591	MELANOMA	-	-	-	-	GPR98	ENST00000405460,p.E3965K|uc003kjv.3,p.E1565K|NM_032119,p.E3965K|uc003kju.3,p.E3965K	retained_intron, protein_coding, processed_transcript	uc003kjv.3	nonsynonymous SNV	exon25	c.G4693A	p.E1565K	VYWKASPDSAGLEDFKPSHGILEFA	VYWKASPDSAGLKDFKPSHGILEFA	1.0	4.0	-	-	2591_5:90052931-90052931 G>A_VYWKASPDSAGLKDFKPSHGILEFA	0.0
2:135119909-135119909 T>C	1.0	4245	COLORECTAL	0.0009	-	-	-	MGAT5	ENST00000281923,p.I437T|uc002ttw.4,p.I437T|ENST00000409645,p.I437T|NM_002410,p.I437T	protein_coding, processed_transcript	uc002ttw.4	nonsynonymous SNV	exon10	c.T1310C	p.I437T	GFVVEQHLNSSDIHHINEIKRQNQS	GFVVEQHLNSSDTHHINEIKRQNQS	9.0	4.0	-	-	4245_2:135119909-135119909 T>C_GFVVEQHLNSSDTHHINEIKRQNQS	0.0
12:53088432-53088432 G>A	0.0	3903	MELANOMA	-	-	-	-	KRT77	NM_175078,p.A353V|ENST00000341809,p.A353V|uc001saw.3,p.A353V|ENST00000537195,p.A120V|uc009zmi.3,p.A111V	retained_intron, protein_coding, nonsense_mediated_decay	uc009zmi.3	nonsynonymous SNV	exon6	c.C332T	p.A111V	QYELIAQRSKDEAEALYQTKYQELQ	QYELIAQRSKDEVEALYQTKYQELQ	1.0	8.0	-	-	3903_12:53088432-53088432 G>A_QYELIAQRSKDEVEALYQTKYQELQ	0.0
1:156281999-156281999 G>A	1.0	3678	MELANOMA	-	-	-	-	CCT3	uc010phl.2,p.R284W|ENST00000368259,p.R292W|ENST00000368261,p.R285W|uc001fon.2,p.R292W|ENST00000295688,p.R330W|NM_001008800,p.R292W|ENST00000472765,p.R285W|NM_005998,p.R330W|uc010phj.2,p.R284W|uc010phk.2,p.R284W|uc001fol.2,p.R330W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010phl.2	nonsynonymous SNV	exon10	c.C850T	p.R284W	TDNNRIARACGARIVSRPEELREDD	TDNNRIARACGAWIVSRPEELREDD	10.0	10.0	-	-	3678_1:156281999-156281999 G>A_TDNNRIARACGAWIVSRPEELREDD	0.0
1:45120566-45120566 C>A	1.0	4129	NSCLC	-	-	-	-	TMEM53	uc001cmc.3,p.A167S|NM_024587,p.A167S|NM_001300748,p.A136S|NM_001300746,p.A94S|uc001cmd.3,p.A94S|uc009vxh.1,p.A50S|NM_001300747,p.A137S|ENST00000372235,p.A137S|ENST00000372237,p.A167S|uc010ola.1,p.A50S	protein_coding, processed_transcript	uc010ola.1	nonsynonymous SNV	exon2	c.G148T	p.A50S	LRALAAILERRAAMLRLLLLVAFAL	LRALAAILERRASMLRLLLLVAFAL	8.0	9.0	-	-	4129_1:45120566-45120566 C>A_LRALAAILERRASMLRLLLLVAFAL	0.0
18:7033087-7033087 A>T	0.0	4298	COLORECTAL	-	-	-	-	LAMA1	uc002knm.3,p.S687T|ENST00000389658,p.S687T|NM_005559,p.S687T|uc010wzj.2,p.S163T	retained_intron, protein_coding	uc010wzj.2	nonsynonymous SNV	exon14	c.T487A	p.S163T	YNSAKMALYRLESVSLDIASSNAID	YNSAKMALYRLETVSLDIASSNAID	4.0	1.0	-	-	4298_18:7033087-7033087 A>T_YNSAKMALYRLETVSLDIASSNAID	0.0
6:152651729-152651729 C>T	1.0	4326	BREAST	-	-	ID=COSM1672895,COSM1672893,COSM1672894;OCCURENCE=1(large_intestine)	-	SYNE1	uc003qou.4,p.M4697I|NM_033071,p.M4626I|ENST00000265368,p.M4697I|ENST00000448038,p.M4626I|ENST00000341594,p.M4444I|uc003qot.4,p.M4626I|ENST00000423061,p.M4626I|NM_182961,p.M4697I|uc010kiz.4,p.M452I|ENST00000367255,p.M4697I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kiz.4	nonsynonymous SNV	exon2	c.G1356A	p.M452I	QSLSELEAQFLRMSKVPTDLAVEEA	QSLSELEAQFLRISKVPTDLAVEEA	8.0	9.0	-	-	4326_6:152651729-152651729 C>T_QSLSELEAQFLRISKVPTDLAVEEA	0.0
2:179444754-179444754 C>G	0.0	4149	OVARIAN	-	-	-	-	TTN	ENST00000342992,p.E19852D|uc021vsz.2,p.E13547D|uc021vtb.2,p.E13355D|ENST00000591111,p.E20779D|ENST00000359218,p.E13480D|NM_003319,p.E13355D|uc031rqd.1,p.E20779D|uc021vta.2,p.E13480D|NM_133437,p.E13547D|ENST00000460472,p.E13355D|uc031rqc.1,p.E22420D|NM_133432,p.E13480D|NM_001256850,p.E20779D|uc021vsy.2,p.E19852D|NM_001267550,p.E22420D|NM_133378,p.E19852D|ENST00000589042,p.E22420D|ENST00000342175,p.E13547D	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon268	c.G62337C	p.E20779D	CSKTSFRVANLEEGKSYFFRVFAEN	CSKTSFRVANLEDGKSYFFRVFAEN	1.0	1.0	-	-	4149_2:179444754-179444754 C>G_CSKTSFRVANLEDGKSYFFRVFAEN	0.0
12:14019007-14019007 C>T	0.0	4301	MELANOMA	-	-	ID=COSM261193;OCCURENCE=1(large_intestine)	-	GRIN2B	NM_000834,p.D46N|ENST00000279593,p.D46N|uc001rbt.2,p.D46N	protein_coding	uc001rbt.2	nonsynonymous SNV	exon2	c.G136A	p.D46N	SIGIAVILVGTSDEVAIKDAHEKDD	SIGIAVILVGTSNEVAIKDAHEKDD	3.0	8.0	-	-	4301_12:14019007-14019007 C>T_SIGIAVILVGTSNEVAIKDAHEKDD	0.0
17:27044353-27044353 C>A	0.0	4078	GASTRIC	-	-	-	-	NARR	NM_001256281,p.R125L|uc031qzq.1,p.R125L	retained_intron, protein_coding, nonsense_mediated_decay	uc031qzq.1	nonsynonymous SNV	exon1	c.G374T	p.R125L	GTPRPRVIVGSPRARVADADPASAP	GTPRPRVIVGSPLARVADADPASAP	7.0	8.0	-	-	4078_17:27044353-27044353 C>A_GTPRPRVIVGSPLARVADADPASAP	0.0
11:113630943-113630943 G>A	1.0	3713	MELANOMA	-	-	-	-	ZW10	ENST00000535142,p.P190S|NM_004724,p.P190S|ENST00000200135,p.P190S|uc001poe.3,p.P190S	protein_coding, nonsense_mediated_decay	uc001poe.3	nonsynonymous SNV	exon5	c.C568T	p.P190S	GEEWQKLIVWKFPPSKDTSSLESYL	GEEWQKLIVWKFSPSKDTSSLESYL	3.0	2.0	-	-	3713_11:113630943-113630943 G>A_GEEWQKLIVWKFSPSKDTSSLESYL	0.0
19:19256828-19256828 C>T	0.0	4046	OVARIAN	-	-	-	-	MEF2B,MEF2BNB-MEF2B	uc002nlo.2,p.G258E|uc002nlp.2,p.G258E|ENST00000602424,p.G258E|ENST00000514819,p.G275E|NM_005919,p.G258E|uc010xqo.2,p.G275E|ENST00000444486,p.G258E	 protein_coding,nonsense_mediated_decay,retained_intron	uc010xqo.2	nonsynonymous SNV	exon8	c.G824A	p.G275E	GSFPFLPGGPPVGAEAWARRVPQPA	GSFPFLPGGPPVEAEAWARRVPQPA	6.0	1.0	-	-	4046_19:19256828-19256828 C>T_GSFPFLPGGPPVEAEAWARRVPQPA	0.0
15:75942041-75942041 G>T	0.0	4316	COLORECTAL	-	-	-	-	SNX33	NM_153271,p.G200C|ENST00000308527,p.G200C|uc002bau.3,p.G200C	protein_coding	uc002bau.3	nonsynonymous SNV	exon1	c.G598T	p.G200C	CFVRSGVEAFILGDVPMMAKIAETY	CFVRSGVEAFILCDVPMMAKIAETY	4.0	6.0	-	-	4316_15:75942041-75942041 G>T_CFVRSGVEAFILCDVPMMAKIAETY	0.0
12:7252304-7252316 CTCCCCATCCTGT>-	1.0	4326	BREAST	-	-	-	-	C1RL	uc001qsn.3,p.R219fs|ENST00000266542,p.R219fs|NM_016546,p.R219fs|NM_001297640,p.R177fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001qsn.3	frameshift deletion	exon5	c.657_669del	p.R219fs	ALTCATPGTWKDRQDGEEVLQCMPVC	ALTCATPGTWKDRRFFSVCLSADGQSPPLPRIRRPSVLPEPSWATSPGKPSPVSTAVGAGPCWGTDGSSLLPTPSTPRTVFLSGRTRV	7.0	5.0	-	-	4326_12:7252304-7252316 CTCCCCATCCTGT>-_ALTCATPGTWKDRRFFSVCLSADGQSPPLPRIRRPSVLPEPSWATSPGKPSPVSTAVGAGPCWGTDGSSLLPTPSTPRTVFLSGRTRV	0.0
10:49791089-49791089 C>T	1.0	4284	COLORECTAL	-	-	-	-	ARHGAP22	ENST00000460425,p.R54K|uc001jgu.4,p.R48K|uc001jgt.4,p.R48K|ENST00000417912,p.R48K|ENST00000435790,p.R54K|NM_001256025,p.R54K|NM_021226,p.R48K|NM_001256024,p.R48K|ENST00000249601,p.R48K|uc010qgm.3,p.R54K|uc010qgl.3,p.R48K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qgm.3	nonsynonymous SNV	exon2	c.G161A	p.R54K	GPVLKAGWLKKQRSIMKNWQQRWFV	GPVLKAGWLKKQKSIMKNWQQRWFV	6.0	6.0	-	-	4284_10:49791089-49791089 C>T_GPVLKAGWLKKQKSIMKNWQQRWFV	0.0
9:79320418-79320418 C>T	0.0	3713	MELANOMA	-	-	-	-	PRUNE2	ENST00000428286,p.E1899K|uc022bih.1,p.E2080K|NM_015225,p.E2258K|ENST00000376718,p.E2258K|uc010mpk.3,p.E2258K	protein_coding, processed_transcript	uc022bih.1	nonsynonymous SNV	exon7	c.G6238A	p.E2080K	GDGSWISDSFSPESQPGARALFDGD	GDGSWISDSFSPKSQPGARALFDGD	2.0	8.0	-	-	3713_9:79320418-79320418 C>T_GDGSWISDSFSPKSQPGARALFDGD	0.0
1:152192471-152192471 C>T	0.0	4346	COLORECTAL	0.0032	-	ID=COSM458591;OCCURENCE=1(cervix),1(lung)	-	HRNR	ENST00000368801,p.R545H|NM_001009931,p.R545H|uc001ezt.2,p.R545H	protein_coding	uc001ezt.2	nonsynonymous SNV	exon3	c.G1634A	p.R545H	HGSGSGQSPSPSRGRHESGSRQSSS	HGSGSGQSPSPSHGRHESGSRQSSS	1.0	8.0	-	-	4346_1:152192471-152192471 C>T_HGSGSGQSPSPSHGRHESGSRQSSS	0.0
18:5891791-5891791 G>T	0.0	4196	COLORECTAL	-	-	-	-	TMEM200C	NM_001080209,p.P91H|ENST00000581347,p.P91H|ENST00000383490,p.P91H|uc002kmx.1,p.P91H	protein_coding	uc002kmx.1	nonsynonymous SNV	exon1	c.C272A	p.P91H	TGTNREGGKQLPPAGSSHRVPTTAN	TGTNREGGKQLPHAGSSHRVPTTAN	3.0	5.0	-	-	4196_18:5891791-5891791 G>T_TGTNREGGKQLPHAGSSHRVPTTAN	0.0
8:113254011-113254011 C>T	0.0	3795	MELANOMA	-	-	-	2	CSMD3	NM_052900,p.G3300D|NM_198124,p.G3429D|uc003ynt.3,p.G3429D|uc003ynu.3,p.G3469D|ENST00000352409,p.G3399D|NM_198123,p.G3469D|uc003yns.3,p.G2671D|ENST00000339701,p.G2739D|ENST00000455883,p.G3300D|uc011lhx.2,p.G3300D|ENST00000343508,p.G3429D|ENST00000297405,p.G3469D	retained_intron, protein_coding, processed_transcript	uc011lhx.2	nonsynonymous SNV	exon64	c.G9899A	p.G3300D	NTWTGKVPICEAGSKILVKDPRPAL	NTWTGKVPICEADSKILVKDPRPAL	2.0	3.0	-	-	3795_8:113254011-113254011 C>T_NTWTGKVPICEADSKILVKDPRPAL	0.0
7:48311901-48311901 G>C	1.0	4298	COLORECTAL	-	-	-	-	ABCA13	uc003toq.2,p.D880H|ENST00000435803,p.D880H|NM_152701,p.D880H|uc010kyr.2,p.D383H	retained_intron, protein_coding, nonsense_mediated_decay	uc010kyr.2	nonsynonymous SNV	exon18	c.G1147C	p.D383H	STSFNFSQLFHSDWPKSPAMNIDFV	STSFNFSQLFHSHWPKSPAMNIDFV	4.0	1.0	-	-	4298_7:48311901-48311901 G>C_STSFNFSQLFHSHWPKSPAMNIDFV	0.0
2:187693087-187693087 G>T	0.0	4266	COLORECTAL	-	-	-	-	ZSWIM2	NM_182521,p.P509Q|uc002upu.1,p.P509Q|ENST00000295131,p.P509Q	protein_coding, nonsense_mediated_decay	uc002upu.1	nonsynonymous SNV	exon9	c.C1526A	p.P509Q	LQDLPTVSFGKIPSQTLLPPIVHKN	LQDLPTVSFGKIQSQTLLPPIVHKN	1.0	4.0	-	-	4266_2:187693087-187693087 G>T_LQDLPTVSFGKIQSQTLLPPIVHKN	0.0
20:8689378-8689378 C>T	1.0	3466	MELANOMA	-	-	ID=COSM1029318,COSM1029319;OCCURENCE=1(endometrium)	-	PLCB1	ENST00000378641,p.S410L|NM_015192,p.S410L|uc002wnc.1,p.S309L|uc002wna.4,p.S410L|uc010zrb.1,p.S309L|ENST00000378637,p.S410L|NM_182734,p.S410L|uc002wnb.4,p.S410L|ENST00000338037,p.S410L	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zrb.1	nonsynonymous SNV	exon12	c.C926T	p.S309L	CAFKTSPFPILLSFENHVDSPKQQA	CAFKTSPFPILLLFENHVDSPKQQA	5.0	4.0	-	-	3466_20:8689378-8689378 C>T_CAFKTSPFPILLLFENHVDSPKQQA	0.0
X:139038347-139038347 G>A	0.0	4258	ENDOMETRIAL	-	-	-	-	CXorf66	ENST00000370540,p.T265I|uc004fbb.3,p.T265I|NM_001013403,p.T265I	protein_coding	uc004fbb.3	nonsynonymous SNV	exon3	c.C794T	p.T265I	RAALLSNSELAETCQPYKKKHLVAK	RAALLSNSELAEICQPYKKKHLVAK	1.0	5.0	-	-	4258_X:139038347-139038347 G>A_RAALLSNSELAEICQPYKKKHLVAK	0.0
13:42876276-42876276 T>C	0.0	4345	COLORECTAL	-	-	-	-	AKAP11	uc001uys.2,p.F1132L|ENST00000025301,p.F1132L|NM_016248,p.F1132L	protein_coding	uc001uys.2	nonsynonymous SNV	exon8	c.T3394C	p.F1132L	LTKKLKGELAKEFAPATPPSTPHNS	LTKKLKGELAKELAPATPPSTPHNS	6.0	2.0	-	-	4345_13:42876276-42876276 T>C_LTKKLKGELAKELAPATPPSTPHNS	0.0
10:32322862-32322862 C>T	1.0	4158	COLORECTAL	-	-	ID=COSM1347617;OCCURENCE=1(large_intestine)	1	KIF5B	uc001iwe.4,p.A406T|NM_004521,p.A406T|ENST00000302418,p.A406T	protein_coding, processed_transcript	uc001iwe.4	nonsynonymous SNV	exon12	c.G1216A	p.A406T	KDITLTNDKPATAIGVIGNFTDAER	KDITLTNDKPATTIGVIGNFTDAER	10.0	3.0	-	-	4158_10:32322862-32322862 C>T_KDITLTNDKPATTIGVIGNFTDAER	0.0
17:39776978-39776978 C>T	1.0	3713	MELANOMA	-	-	-	-	KRT17	uc002hxh.2,p.D372N|ENST00000311208,p.D372N|NM_000422,p.D372N|ENST00000540235,p.D531N	retained_intron, protein_coding	uc002hxh.2	nonsynonymous SNV	exon6	c.G1114A	p.D372N	MEQQNQEYKILLDVKTRLEQEIATY	MEQQNQEYKILLNVKTRLEQEIATY	3.0	1.0	-	-	3713_17:39776978-39776978 C>T_MEQQNQEYKILLNVKTRLEQEIATY	0.0
5:100147675-100147675 T>A	0.0	4345	COLORECTAL	-	-	-	-	ST8SIA4	NM_005668,p.D319V|uc003knk.3,p.D319V|ENST00000231461,p.D319V	protein_coding, processed_transcript, nonsense_mediated_decay	uc003knk.3	nonsynonymous SNV	exon5	c.A956T	p.D319V	LNGKAVKYHYYDDLKYRYFSNASPH	LNGKAVKYHYYDVLKYRYFSNASPH	4.0	10.0	-	-	4345_5:100147675-100147675 T>A_LNGKAVKYHYYDVLKYRYFSNASPH	0.0
8:76476257-76476257 G>A	0.0	4301	MELANOMA	-	-	-	-	HNF4G	uc003yaq.3,p.E385K|uc003yar.3,p.E422K|NM_004133,p.E422K|ENST00000354370,p.E385K|ENST00000396423,p.E422K	protein_coding, processed_transcript	uc003yar.3	nonsynonymous SNV	exon10	c.G1264A	p.E422K	TPLPSPPQGSGQEQYKIAANQASVI	TPLPSPPQGSGQKQYKIAANQASVI	2.0	5.0	-	-	4301_8:76476257-76476257 G>A_TPLPSPPQGSGQKQYKIAANQASVI	0.0
22:37414289-37414289 A>C	0.0	4189	MELANOMA	-	-	-	-	TST	uc031rxn.1,p.L162R|uc003aqg.4,p.L162R|ENST00000249042,p.L162R|NM_001270483,p.L162R|uc003aqh.4,p.L162R|ENST00000403892,p.L162R|NM_003312,p.L162R	protein_coding	uc031rxn.1	nonsynonymous SNV	exon2	c.T485G	p.L162R	PAVFKATLDRSLLKTYEQVLENLES	PAVFKATLDRSLRKTYEQVLENLES	3.0	6.0	-	-	4189_22:37414289-37414289 A>C_PAVFKATLDRSLRKTYEQVLENLES	0.0
19:54973880-54973880 G>A	1.0	4000	MELANOMA	-	-	-	-	LENG9	uc010yez.2,p.P299L|NM_198988,p.P299L|ENST00000333834,p.P299L	protein_coding	uc010yez.2	nonsynonymous SNV	exon1	c.C896T	p.P299L	GGSAETTEAEWGPAAWPEDKRARLS	GGSAETTEAEWGLAAWPEDKRARLS	4.0	5.0	-	-	4000_19:54973880-54973880 G>A_GGSAETTEAEWGLAAWPEDKRARLS	0.0
15:51017458-51017458 C>T	1.0	4126	NSCLC	-	-	-	-	SPPL2A	NM_032802,p.M403I|ENST00000261854,p.M403I|uc001zyv.3,p.M403I	retained_intron, protein_coding, processed_transcript	uc001zyv.3	nonsynonymous SNV	exon12	c.G1209A	p.M403I	KLIYFSVMSVCLMPVSILGFGDIIV	KLIYFSVMSVCLIPVSILGFGDIIV	9.0	1.0	-	-	4126_15:51017458-51017458 C>T_KLIYFSVMSVCLIPVSILGFGDIIV	0.0
6:17850596-17850596 G>C	0.0	4335	COLORECTAL	-	-	-	-	KIF13A	ENST00000378826,p.F225L|ENST00000378843,p.F225L|uc003nch.4,p.F225L|ENST00000378816,p.F225L|NM_022113,p.F225L|uc003nci.4,p.F225L|NM_001105567,p.F225L|ENST00000259711,p.F225L|NM_001105566,p.F225L|ENST00000378814,p.F225L|NM_001105568,p.F225L|uc003ncg.4,p.F225L|uc003ncf.3,p.F225L	retained_intron, protein_coding, processed_transcript	uc003nci.4	nonsynonymous SNV	exon8	c.C675G	p.F225L	NMNEESSRSHAVFNIIITQTLYDLQ	NMNEESSRSHAVLNIIITQTLYDLQ	7.0	2.0	-	-	4335_6:17850596-17850596 G>C_NMNEESSRSHAVLNIIITQTLYDLQ	0.0
2:170917883-170917883 G>T	1.0	4234	NSCLC	-	-	-	-	UBR3	ENST00000418381,p.C1650F|uc002ufu.4,p.C156F|uc010zdi.2,p.C1650F|ENST00000439681,p.C350F|uc002uft.4,p.C507F|ENST00000272793,p.C1650F|uc010fqa.3,p.C471F|ENST00000392631,p.C471F|uc010zdj.2,p.C341F|NM_172070,p.C1650F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zdj.2	nonsynonymous SNV	exon10	c.G1022T	p.C341F	SPESMEKCLQDFCLPFLRITSLLQH	SPESMEKCLQDFFLPFLRITSLLQH	7.0	7.0	-	-	4234_2:170917883-170917883 G>T_SPESMEKCLQDFFLPFLRITSLLQH	0.0
16:14015933-14015933 C>T	1.0	3903	MELANOMA	-	-	-	1	ERCC4	uc010bva.3,p.P85S|ENST00000575156,p.P85S|ENST00000311895,p.P85S|uc002dce.2,p.P85S|NM_005236,p.P85S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bva.3	nonsynonymous SNV	exon2	c.C253T	p.P85S	INQLKIEGVEHLPRRVTNEITSNSR	INQLKIEGVEHLSRRVTNEITSNSR	6.0	7.0	-	-	3903_16:14015933-14015933 C>T_INQLKIEGVEHLSRRVTNEITSNSR	0.0
1:1198734-1198734 G>A	1.0	3713	MELANOMA	-	-	-	-	UBE2J2	uc001ado.3,p.P71L|NM_194315,p.P71L|ENST00000400930,p.P71L|ENST00000422076,p.P71L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ado.3	nonsynonymous SNV	exon4	c.C212T	p.P71L	YRHYVVRGPEMTPYEGGYYHGKLIF	YRHYVVRGPEMTLYEGGYYHGKLIF	9.0	10.0	-	-	3713_1:1198734-1198734 G>A_YRHYVVRGPEMTLYEGGYYHGKLIF	0.0
3:47164353-47164353 C>A	1.0	4000	MELANOMA	-	-	-	1	SETD2	ENST00000412450,p.Q547H|ENST00000409792,p.Q591H|uc003cqs.3,p.Q591H|NM_014159,p.Q591H|uc003cqv.3,p.Q580H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003cqv.3	nonsynonymous SNV	exon3	c.G1740T	p.Q580H	NEEIKQSHSFSLQTPCSKGSELRMI	NEEIKQSHSFSLHTPCSKGSELRMI	8.0	5.0	-	-	4000_3:47164353-47164353 C>A_NEEIKQSHSFSLHTPCSKGSELRMI	0.0
19:15296174-15296174 G>C	0.0	4258	ENDOMETRIAL	-	-	-	-	NOTCH3	uc002nan.3,p.S730R|ENST00000263388,p.S730R|ENST00000601011,p.S729R|NM_000435,p.S730R|uc002nao.1,p.S730R	retained_intron, protein_coding, nonsense_mediated_decay	uc002nao.1	nonsynonymous SNV	exon14	c.C2190G	p.S730R	CVCEPGWSGPRCSQSLARDACESQP	CVCEPGWSGPRCRQSLARDACESQP	7.0	4.0	-	-	4258_19:15296174-15296174 G>C_CVCEPGWSGPRCRQSLARDACESQP	0.0
9:123908397-123908397 G>A	1.0	3713	MELANOMA	-	-	-	1	CNTRL	ENST00000373847,p.G556S|uc004bky.1,p.G712S|ENST00000373850,p.G556S|NM_007018,p.G1108S|uc004bla.1,p.G556S|ENST00000238341,p.G1108S|uc004bkx.1,p.G1108S|ENST00000373855,p.G1108S	protein_coding, processed_transcript	uc004bla.1	nonsynonymous SNV	exon12	c.G1666A	p.G556S	NVLDLTGSDNKGGFENVLEEIAELR	NVLDLTGSDNKGSFENVLEEIAELR	4.0	4.0	-	-	3713_9:123908397-123908397 G>A_NVLDLTGSDNKGSFENVLEEIAELR	0.0
12:52629114-52629114 G>A	0.0	3713	MELANOMA	-	-	-	-	KRT7	ENST00000331817,p.R167Q|uc001saa.1,p.R167Q|NM_005556,p.R167Q	retained_intron, protein_coding, processed_transcript	uc001saa.1	nonsynonymous SNV	exon2	c.G500A	p.R167Q	LQVDGGRLEAELRSMQDVVEDFKNK	LQVDGGRLEAELQSMQDVVEDFKNK	1.0	6.0	-	-	3713_12:52629114-52629114 G>A_LQVDGGRLEAELQSMQDVVEDFKNK	0.0
1:158622439-158622439 G>A	0.0	4196	COLORECTAL	-	-	-	-	SPTA1	ENST00000368147,p.R1065C|NM_003126,p.R1065C|ENST00000368148,p.R1065C|uc001fst.1,p.R1065C	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon23	c.C3193T	p.R1065C	ITQRQEQIENQYRSLLDRAEERRRR	ITQRQEQIENQYCSLLDRAEERRRR	4.0	9.0	-	-	4196_1:158622439-158622439 G>A_ITQRQEQIENQYCSLLDRAEERRRR	0.0
1:99127378-99127378 T>G	1.0	4237	NSCLC	-	-	-	-	SNX7	ENST00000529992,p.F31V|uc010oud.2,p.F31V|NM_015976,p.F31V|ENST00000306121,p.F31V|uc010ouc.2,p.F31V|NM_152238,p.F31V	protein_coding, processed_transcript, nonsense_mediated_decay	uc010oud.2	nonsynonymous SNV	exon1	c.T91G	p.F31V	GANGESPGGGAPFPGSSGSSALLQA	GANGESPGGGAPVPGSSGSSALLQA	7.0	10.0	-	-	4237_1:99127378-99127378 T>G_GANGESPGGGAPVPGSSGSSALLQA	0.0
19:36884487-36884487 T>G	0.0	4298	COLORECTAL	-	-	-	-	ZFP82	NM_133466,p.K252T|ENST00000392161,p.K252T|ENST00000392171,p.K252T|uc002ody.1,p.K252T	retained_intron, protein_coding	uc002ody.1	nonsynonymous SNV	exon5	c.A755C	p.K252T	DLRVHQKMHIGEKPYECKECGKAFR	DLRVHQKMHIGETPYECKECGKAFR	3.0	2.0	-	-	4298_19:36884487-36884487 T>G_DLRVHQKMHIGETPYECKECGKAFR	0.0
12:116446341-116446341 G>A	1.0	4244	COLORECTAL	0.0014	-	-	-	MED13L	uc001tvw.3,p.P626L|ENST00000281928,p.P626L|NM_015335,p.P626L	retained_intron, protein_coding, processed_transcript	uc001tvw.3	nonsynonymous SNV	exon10	c.C1877T	p.P626L	ETALYCGIRPSNPESSEKWWHSYRL	ETALYCGIRPSNLESSEKWWHSYRL	6.0	7.0	-	-	4244_12:116446341-116446341 G>A_ETALYCGIRPSNLESSEKWWHSYRL	0.0
10:33475386-33475386 T>G	1.0	3919	MELANOMA	-	-	-	-	NRP1	uc001iwx.4,p.D698A|ENST00000265371,p.D698A|NM_003873,p.D698A|uc001iww.4,p.D510A|uc001iwv.4,p.D698A|ENST00000374875,p.D510A|uc001iwy.4,p.D691A|ENST00000395995,p.D698A|NM_001244973,p.D691A|ENST00000374867,p.D698A	protein_coding, processed_transcript	uc001iwy.4	nonsynonymous SNV	exon14	c.A2072C	p.D691A	HTGDGNFIYSQADENQKGKVARLVS	HTGDGNFIYSQAAENQKGKVARLVS	9.0	3.0	-	-	3919_10:33475386-33475386 T>G_HTGDGNFIYSQAAENQKGKVARLVS	0.0
7:43918638-43918638 C>T	1.0	4078	GASTRIC	-	-	-	-	URGCP	uc011kbj.2,p.A99T|ENST00000402306,p.A133T|uc003tix.3,p.A133T|NM_001290075,p.A99T|ENST00000455877,p.A99T|ENST00000443736,p.A99T|ENST00000426198,p.A99T|ENST00000223341,p.A99T|NM_001077663,p.A142T|uc003tiw.3,p.A142T|ENST00000453200,p.A142T|ENST00000336086,p.A99T|NM_001290076,p.A99T|NM_001077664,p.A99T|uc003tiv.3,p.A67T|NM_017920,p.A133T|uc003tiu.3,p.A99T|uc003tiz.3,p.A99T|ENST00000447717,p.A99T|uc003tiy.3,p.A99T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kbj.2	nonsynonymous SNV	exon7	c.G295A	p.A99T	RNTTMVLDVLPDARPVEKESQMEEE	RNTTMVLDVLPDTRPVEKESQMEEE	8.0	2.0	-	-	4078_7:43918638-43918638 C>T_RNTTMVLDVLPDTRPVEKESQMEEE	0.0
X:140995299-140995299 C>A	1.0	4281	COLORECTAL	-	-	-	-	MAGEC1	NM_005462,p.D703E|ENST00000285879,p.D703E|uc022cfi.1,p.D362E|uc004fbt.3,p.D703E	protein_coding	uc022cfi.1	nonsynonymous SNV	exon1	c.C1086A	p.D362E	PLQIPQSPLEGEDSLSSLHFPQSPP	PLQIPQSPLEGEESLSSLHFPQSPP	2.0	6.0	-	-	4281_X:140995299-140995299 C>A_PLQIPQSPLEGEESLSSLHFPQSPP	0.0
X:51076226-51076226 G>A	0.0	4316	COLORECTAL	-	-	-	-	NUDT10	ENST00000356450,p.A137T|NM_153183,p.A137T|uc004dpi.4,p.A137T|ENST00000376006,p.A137T|uc004dph.3,p.A137T	protein_coding	uc004dpi.4	nonsynonymous SNV	exon1	c.G409A	p.A137T	AIKVLQCHKPVHAEYLEKLKLGGSP	AIKVLQCHKPVHTEYLEKLKLGGSP	1.0	6.0	-	-	4316_X:51076226-51076226 G>A_AIKVLQCHKPVHTEYLEKLKLGGSP	0.0
4:183664338-183664338 G>A	1.0	3998	MELANOMA	-	-	-	-	TENM3	ENST00000406950,p.G1132E|uc003ivd.1,p.G1132E|ENST00000511685,p.G1132E|uc003ive.1,p.G538E|NM_001080477,p.G1132E	retained_intron, protein_coding, processed_transcript	uc003ive.1	nonsynonymous SNV	exon11	c.G1613A	p.G538E	HVLDVQNGILYKGNGENQFISQQPP	HVLDVQNGILYKENGENQFISQQPP	9.0	5.0	-	-	3998_4:183664338-183664338 G>A_HVLDVQNGILYKENGENQFISQQPP	0.0
8:27097502-27097502 G>A	0.0	4298	COLORECTAL	-	-	-	-	STMN4	uc003xfj.3,p.R193W|ENST00000350889,p.R193W|ENST00000265770,p.R166W|NM_001283054,p.R166W|NM_030795,p.R193W|uc003xfk.3,p.R166W	retained_intron, protein_coding	uc003xfk.3	nonsynonymous SNV	exon5	c.C496T	p.R166W	ENREAHLAAMLERLQEKDKHAEEVR	ENREAHLAAMLEWLQEKDKHAEEVR	2.0	7.0	-	-	4298_8:27097502-27097502 G>A_ENREAHLAAMLEWLQEKDKHAEEVR	0.0
5:140604405-140604405 A>G	1.0	4284	COLORECTAL	-	-	-	-	PCDHB14	NM_018934,p.D443G|ENST00000515856,p.D290G|uc003ljb.3,p.D443G|ENST00000239449,p.D443G	protein_coding	uc003ljb.3	nonsynonymous SNV	exon1	c.A1328G	p.D443G	LKTEYNITVLLSDVNDNAPTFTQTS	LKTEYNITVLLSGVNDNAPTFTQTS	8.0	10.0	-	-	4284_5:140604405-140604405 A>G_LKTEYNITVLLSGVNDNAPTFTQTS	0.0
16:77369780-77369780 C>T	0.0	4275	COLORECTAL	-	-	-	-	ADAMTS18	uc010chc.1,p.V166I|uc002ffc.4,p.V578I|NM_199355,p.V578I|ENST00000282849,p.V578I|uc002ffe.1,p.V274I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010chc.1	nonsynonymous SNV	exon7	c.G496A	p.V166I	CGLSMWCRQGQCVKFGELGPRPIHG	CGLSMWCRQGQCIKFGELGPRPIHG	4.0	5.0	-	-	4275_16:77369780-77369780 C>T_CGLSMWCRQGQCIKFGELGPRPIHG	0.0
5:83402543-83402543 T>A	0.0	4284	COLORECTAL	-	-	-	-	EDIL3	ENST00000380138,p.Y182F|NM_001278642,p.Y182F|uc003kip.1,p.Y182F|NM_005711,p.Y192F|ENST00000296591,p.Y192F|uc003kio.1,p.Y192F	protein_coding, processed_transcript	uc003kip.1	nonsynonymous SNV	exon5	c.A545T	p.Y182F	HRALFGLQKWYPYYARLNKKGLINA	HRALFGLQKWYPFYARLNKKGLINA	6.0	1.0	-	-	4284_5:83402543-83402543 T>A_HRALFGLQKWYPFYARLNKKGLINA	0.0
5:45645472-45645472 A>T	0.0	2556	MELANOMA	-	-	-	-	HCN1	ENST00000303230,p.F222I|NM_021072,p.F222I|uc003jok.3,p.F222I	protein_coding	uc003jok.3	nonsynonymous SNV	exon2	c.T664A	p.F222I	PKVIKMNYLKSWFVVDFISSIPVDY	PKVIKMNYLKSWIVVDFISSIPVDY	3.0	2.0	-	-	2556_5:45645472-45645472 A>T_PKVIKMNYLKSWIVVDFISSIPVDY	0.0
15:51217323-51217323 T>C	1.0	4301	MELANOMA	-	-	-	-	AP4E1	ENST00000560508,p.V75A|NM_001252127,p.V75A|NM_007347,p.V150A|ENST00000561393,p.V75A|ENST00000261842,p.V150A|uc001zyx.2,p.V150A|uc021skz.1,p.V75A|ENST00000561441,p.V150A|uc010ufi.2,p.V150A|ENST00000558439,p.V150A	protein_coding, processed_transcript, nonsense_mediated_decay	uc021skz.1	nonsynonymous SNV	exon5	c.T224C	p.V75A	VVKDLQSTNLVEVCMALTVVSQIFP	VVKDLQSTNLVEACMALTVVSQIFP	7.0	6.0	-	-	4301_15:51217323-51217323 T>C_VVKDLQSTNLVEACMALTVVSQIFP	0.0
12:25054798-25054798 C>T	0.0	4235	COLORECTAL	-	-	-	-	BCAT1	ENST00000539282,p.A22T|uc010six.2,p.A22T|NM_001178093,p.A22T	protein_coding, processed_transcript	uc010six.2	nonsynonymous SNV	exon2	c.G64A	p.A22T	ALARQDCSNGCSAECTGEGGSKEVV	ALARQDCSNGCSTECTGEGGSKEVV	5.0	8.0	-	-	4235_12:25054798-25054798 C>T_ALARQDCSNGCSTECTGEGGSKEVV	0.0
6:152551708-152551708 C>A	0.0	4126	NSCLC	-	-	-	-	SYNE1	NM_182961,p.V7057F|ENST00000423061,p.V6986F|uc003qou.4,p.V7057F|ENST00000356820,p.V1581F|NM_033071,p.V6986F|uc003qot.4,p.V6986F|ENST00000367255,p.V7057F|ENST00000341594,p.V6669F|uc003qos.4,p.V1581F|ENST00000448038,p.V6986F|ENST00000265368,p.V7057F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003qou.4	nonsynonymous SNV	exon115	c.G21169T	p.V7057F	LKQQHRIGDQASVQNALKDCQDLED	LKQQHRIGDQASFQNALKDCQDLED	6.0	10.0	-	-	4126_6:152551708-152551708 C>A_LKQQHRIGDQASFQNALKDCQDLED	0.0
16:83250989-83250989 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	CDH13	uc002fgx.3,p.L175F|NM_001220488,p.L222F|NM_001257,p.L175F|uc010vnu.2,p.L136F|ENST00000566620,p.L175F|uc010vns.2,p.L222F|ENST00000268613,p.L222F|ENST00000428848,p.L136F|NM_001220489,p.L136F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vnu.2	nonsynonymous SNV	exon4	c.C406T	p.L136F	VDSDRPERSKFRLTGKGVDQEPKGI	VDSDRPERSKFRFTGKGVDQEPKGI	5.0	10.0	-	-	4258_16:83250989-83250989 C>T_VDSDRPERSKFRFTGKGVDQEPKGI	0.0
8:145668159-145668159 A>G	1.0	4046	OVARIAN	-	-	-	-	TONSL	ENST00000409379,p.M160T|NM_013432,p.M160T|uc011llg.2,p.M160T	retained_intron, protein_coding	uc011llg.2	nonsynonymous SNV	exon5	c.T479C	p.M160T	LEGTLAQGELNEMRTRLYLNLGLTF	LEGTLAQGELNETRTRLYLNLGLTF	8.0	1.0	-	-	4046_8:145668159-145668159 A>G_LEGTLAQGELNETRTRLYLNLGLTF	0.0
20:45131112-45131112 C>A	0.0	4316	COLORECTAL	-	-	-	-	ZNF334	uc002xsc.4,p.G289V|ENST00000457685,p.G251V|ENST00000347606,p.G289V|uc010ghl.4,p.G288V|NM_018102,p.G289V|uc002xsb.4,p.G251V|uc031rtw.1,p.G251V|uc002xsa.4,p.G312V|ENST00000593880,p.G312V|uc002xsd.4,p.G251V|NM_001270497,p.G288V	protein_coding	uc031rtw.1	nonsynonymous SNV	exon5	c.G752T	p.G251V	KTSLTRHRRIHTGERPYECSECRKT	KTSLTRHRRIHTVERPYECSECRKT	3.0	1.0	-	-	4316_20:45131112-45131112 C>A_KTSLTRHRRIHTVERPYECSECRKT	0.0
16:814723-814723 T>A	0.0	4196	COLORECTAL	-	-	-	-	MSLN	ENST00000382862,p.L126H|uc010brd.1,p.L125H|NM_013404,p.L126H|uc002cjt.1,p.L126H|ENST00000563941,p.L126H|uc002cjw.2,p.L126H|NM_001177355,p.L126H|ENST00000569566,p.L126H|ENST00000563651,p.L126H|ENST00000566549,p.L126H|ENST00000545450,p.L126H|uc002cju.1,p.L126H|NM_005823,p.L126H	protein_coding	uc010brd.1	nonsynonymous SNV	exon6	c.T374A	p.L125H	DLDALPLDLLLFLNPDAFSGPQACT	DLDALPLDLLLFHNPDAFSGPQACT	6.0	5.0	-	-	4196_16:814723-814723 T>A_DLDALPLDLLLFHNPDAFSGPQACT	0.0
15:59752274-59752274 A>C	1.0	2369	MELANOMA	-	-	-	-	FAM81A	uc002agc.2,p.K55Q|ENST00000560087,p.K64Q|ENST00000558348,p.K55Q|ENST00000560074,p.K55Q|NM_152450,p.K55Q|ENST00000560474,p.K64Q|ENST00000557914,p.K55Q|ENST00000288228,p.K55Q|ENST00000561361,p.K55Q|uc010uha.2,p.K55Q|ENST00000559628,p.K55Q|ENST00000560394,p.K55Q	retained_intron, protein_coding, processed_transcript	uc010uha.2	nonsynonymous SNV	exon3	c.A163C	p.K55Q	TTAALVEHAFRIKDDIVNSLQKMQN	TTAALVEHAFRIQDDIVNSLQKMQN	7.0	5.0	-	-	2369_15:59752274-59752274 A>C_TTAALVEHAFRIQDDIVNSLQKMQN	0.0
16:24583233-24583233 C>T	1.0	4000	MELANOMA	-	-	-	-	RBBP6	NM_006910,p.P1616S|uc002dmi.3,p.P1582S|uc010bxr.3,p.P776S|uc002dmh.3,p.P1616S|ENST00000381039,p.P776S|ENST00000319715,p.P1616S|ENST00000348022,p.P1582S|NM_018703,p.P1582S|uc002dmk.3,p.P1449S	retained_intron, protein_coding	uc010bxr.3	nonsynonymous SNV	exon11	c.C2326T	p.P776S	TGQIDKSTVKPKPQLSHSSRLSSDL	TGQIDKSTVKPKSQLSHSSRLSSDL	10.0	9.0	-	-	4000_16:24583233-24583233 C>T_TGQIDKSTVKPKSQLSHSSRLSSDL	0.0
1:236914796-236914796 C>A	0.0	4240	BREAST	-	-	ID=COSM400979;OCCURENCE=1(lung)	-	ACTN2	ENST00000366578,p.F561L|uc001hyg.2,p.F353L|uc009xgi.1,p.F561L|uc001hyf.2,p.F561L|NM_001278344,p.F353L|NM_001103,p.F561L|ENST00000546208,p.F55L|uc010pxu.1,p.F250L|NM_001278343,p.F561L|ENST00000542672,p.F561L	protein_coding, processed_transcript	uc010pxu.1	nonsynonymous SNV	exon8	c.C750A	p.F250L	EEIQSLITAHEQFKATLPEADGERQ	EEIQSLITAHEQLKATLPEADGERQ	2.0	6.0	-	-	4240_1:236914796-236914796 C>A_EEIQSLITAHEQLKATLPEADGERQ	0.0
10:30749736-30749736 C>T	0.0	4160	COLORECTAL	-	-	-	-	MAP3K8	NM_001244134,p.R459W|uc001ivj.2,p.R459W|NM_005204,p.R459W|ENST00000542547,p.R459W|ENST00000263056,p.R459W|uc009xlf.2,p.R459W|ENST00000375321,p.R459W|uc001ivi.2,p.R459W	protein_coding	uc009xlf.2	nonsynonymous SNV	exon8	c.C1375T	p.R459W	DLGALAGYFNLVRGPPTLEYG	DLGALAGYFNLVWGPPTLEYG	7.0	7.0	-	-	4160_10:30749736-30749736 C>T_DLGALAGYFNLVWGPPTLEYG	0.0
5:139917106-139917106 C>T	1.0	4252	COLORECTAL	-	-	-	-	ANKHD1,ANKHD1-EIF4EBP3	ENST00000437495,p.A415V|NM_017747,p.A2387V|uc011czh.1,p.A1143V|uc003lfs.2,p.A2387V|NM_020690,p.A2387V|ENST00000544120,p.A711V|uc003lfx.1,p.A541V|ENST00000433049,p.A926V|ENST00000431508,p.A1060V|ENST00000297183,p.A2387V|uc010jfl.3,p.A763V|uc003lfr.3,p.A2387V|ENST00000360839,p.A2387V|uc003lfw.3,p.A1042V|ENST00000532219,p.A2387V	retained_intron, protein_coding, processed_transcript	uc011czh.1	nonsynonymous SNV	exon11	c.C3428T	p.A1143V	RIRQGGSVAQAPAGTSFVAPVGHSG	RIRQGGSVAQAPVGTSFVAPVGHSG	10.0	9.0	-	-	4252_5:139917106-139917106 C>T_RIRQGGSVAQAPVGTSFVAPVGHSG	0.0
3:192078301-192078301 T>C	0.0	4266	COLORECTAL	-	-	-	-	FGF12	ENST00000264730,p.R14G|ENST00000418610,p.R14G|ENST00000450716,p.R14G|NM_004113,p.R14G|ENST00000445105,p.R14G|uc003fsy.3,p.R14G	retained_intron, protein_coding, processed_transcript	uc003fsy.3	nonsynonymous SNV	exon3	c.A40G	p.R14G	ESKEPQLKGIVTRLFSQQGYFLQMH	ESKEPQLKGIVTGLFSQQGYFLQMH	4.0	3.0	-	-	4266_3:192078301-192078301 T>C_ESKEPQLKGIVTGLFSQQGYFLQMH	0.0
5:140724589-140724589 G>A	1.0	3713	MELANOMA	-	-	-	-	PCDHGA3	NM_032011,p.R330K|NM_018916,p.R330K|uc003ljm.2,p.R330K|uc011dap.2,p.R330K|ENST00000253812,p.R330K	protein_coding	uc011dap.2	nonsynonymous SNV	exon1	c.G989A	p.R330K	KIEAQDGPGLLSRAKILVTVLDVND	KIEAQDGPGLLSKAKILVTVLDVND	3.0	6.0	-	-	3713_5:140724589-140724589 G>A_KIEAQDGPGLLSKAKILVTVLDVND	0.0
12:48272770-48272770 C>T	1.0	3713	MELANOMA	-	-	-	-	VDR	uc001rqn.3,p.G43S|ENST00000550314,p.G43S|NM_001017536,p.G93S|NM_000376,p.G43S|ENST00000548664,p.G43S|ENST00000395324,p.G43S|uc001rqm.3,p.G43S|ENST00000546653,p.G43S|uc001rql.3,p.G93S|NM_001017535,p.G43S|ENST00000229022,p.G43S|ENST00000550325,p.G93S|ENST00000549336,p.G43S	protein_coding, nonsense_mediated_decay	uc001rqn.3	nonsynonymous SNV	exon3	c.G127A	p.G43S	ATGFHFNAMTCEGCKGFFRRSMKRK	ATGFHFNAMTCESCKGFFRRSMKRK	5.0	4.0	-	-	3713_12:48272770-48272770 C>T_ATGFHFNAMTCESCKGFFRRSMKRK	0.0
10:31799763-31799763 T>A	0.0	4259	COLORECTAL	-	-	-	2	ZEB1	uc001ivv.4,p.L195H|NM_001174096,p.L216H|NM_001174095,p.L148H|uc009xlj.1,p.L141H|ENST00000542815,p.L148H|uc010qeh.2,p.L148H|ENST00000446923,p.L199H|uc001ivs.4,p.L215H|ENST00000559476,p.L199H|uc001ivu.4,p.L216H|ENST00000361642,p.L216H|ENST00000424869,p.L216H|NM_030751,p.L215H|NM_001128128,p.L199H|ENST00000560721,p.L195H|ENST00000320985,p.L215H|ENST00000561212,p.L223H|ENST00000558440,p.L141H|uc010qeg.1,p.L74H|uc009xlo.2,p.L198H|NM_001174094,p.L198H|NM_001174093,p.L195H|uc009xlp.3,p.L199H	retained_intron, protein_coding, processed_transcript	uc010qeh.2	nonsynonymous SNV	exon4	c.T443A	p.L148H	SLCSYTFAYRTQLERHMTSHKSGRD	SLCSYTFAYRTQHERHMTSHKSGRD	6.0	1.0	-	-	4259_10:31799763-31799763 T>A_SLCSYTFAYRTQHERHMTSHKSGRD	0.0
X:119500396-119500396 C>T	0.0	4238	COLORECTAL	-	-	ID=COSM3424404,COSM3424405;OCCURENCE=1(large_intestine)	-	ATP1B4	ENST00000539306,p.A27V|NM_001142447,p.A27V|uc011mtx.2,p.A27V|uc004esq.3,p.A27V|uc011mty.2,p.A27V|uc004esr.3,p.A27V|ENST00000361319,p.A27V|ENST00000218008,p.A27V|NM_012069,p.A27V	protein_coding	uc011mty.2	nonsynonymous SNV	exon2	c.C80T	p.A27V	YSYRYRLDDPDEANQNYLADEEEEA	YSYRYRLDDPDEVNQNYLADEEEEA	1.0	10.0	-	-	4238_X:119500396-119500396 C>T_YSYRYRLDDPDEVNQNYLADEEEEA	0.0
12:50294951-50294951 G>A	0.0	4078	GASTRIC	-	-	ID=COSM300472;OCCURENCE=1(large_intestine)	-	FAIM2	ENST00000320634,p.A58V|ENST00000550635,p.A58V|NM_012306,p.A58V|uc001rvj.2,p.A58V|ENST00000550195,p.A58V	protein_coding, nonsense_mediated_decay	uc001rvj.2	nonsynonymous SNV	exon2	c.C173T	p.A58V	GMKAGAFPPAPTAVPLHPSWAYVDP	GMKAGAFPPAPTVVPLHPSWAYVDP	2.0	10.0	-	-	4078_12:50294951-50294951 G>A_GMKAGAFPPAPTVVPLHPSWAYVDP	0.0
11:111941931-111941931 ->T	1.0	4346	COLORECTAL	-	-	-	-	PIH1D2	ENST00000525744,p.N91fs|ENST00000431456,p.N126fs|ENST00000532211,p.N126fs|ENST00000530641,p.N126fs|uc009yyl.3,p.N126fs|ENST00000280350,p.N126fs|ENST00000528775,p.N126fs|NM_138789,p.N126fs|uc010rws.1,p.N126fs|uc001pmp.4,p.N126fs|NM_001082619,p.N126fs	protein_coding, processed_transcript, non_stop_decay	uc010rws.1	frameshift insertion	exon4	c.377dupA	p.N126fs	VLHAAEKDQVKKNQLIQMAMKCIEE	VLHAAEKDQVKKKSVNSDGHEMH	4.0	5.0	-	-	4346_11:111941931-111941931 ->T_VLHAAEKDQVKKKSVNSDGHEMH	0.0
7:102967057-102967057 G>A	1.0	3713	MELANOMA	-	-	-	-	DNAJC2	uc010lix.3,p.P169S|uc003vbo.3,p.P169S|ENST00000379263,p.P169S|ENST00000454277,p.P95S|NM_014377,p.P169S|NM_001129887,p.P169S|ENST00000249270,p.P169S	retained_intron, protein_coding, nonsense_mediated_decay	uc010lix.3	nonsynonymous SNV	exon5	c.C505T	p.P169S	FNSVDPTFDNSVPSKSEAKDNFFEV	FNSVDPTFDNSVSSKSEAKDNFFEV	7.0	8.0	-	-	3713_7:102967057-102967057 G>A_FNSVDPTFDNSVSSKSEAKDNFFEV	0.0
10:72492066-72492066 G>A	1.0	3713	MELANOMA	-	-	-	-	ADAMTS14	NM_139155,p.E390K|NM_080722,p.E387K|ENST00000373208,p.E390K|ENST00000373207,p.E387K|uc001jrh.3,p.E387K|uc001jrg.3,p.E390K	protein_coding	uc001jrh.3	nonsynonymous SNV	exon7	c.G1159A	p.E387K	MCHPLRSCALNHEDGFSSAFVIAHE	MCHPLRSCALNHKDGFSSAFVIAHE	2.0	7.0	-	-	3713_10:72492066-72492066 G>A_MCHPLRSCALNHKDGFSSAFVIAHE	0.0
10:115391292-115391292 ->AG	0.0	4160	COLORECTAL	-	-	-	-	NRAP	ENST00000369360,p.L579fs|NM_006175,p.L571fs|uc001lal.4,p.L606fs|uc001laj.4,p.L606fs|NM_001261463,p.L606fs|uc001lak.4,p.L571fs|ENST00000360478,p.L571fs|ENST00000359988,p.L606fs|NM_198060,p.L606fs|ENST00000369358,p.L614fs	protein_coding	uc001lal.4	frameshift insertion	exon18	c.1817_1818insCT	p.L606fs	AMGTADSRLLHSLQIAKMSSEVEYK	AMGTADSRLLHSLCRLLR	1.0	8.0	-	-	4160_10:115391292-115391292 ->AG_AMGTADSRLLHSLCRLLR	0.0
2:100210490-100210490 C>T	0.0	4160	COLORECTAL	-	-	-	1	AFF3	uc010yvr.1,p.V698M|uc010fiq.1,p.V545M|ENST00000409579,p.V570M|uc002taf.3,p.V570M|ENST00000317233,p.V545M|uc002tag.3,p.V545M|uc002tah.1,p.V570M|NM_002285,p.V545M|NM_001025108,p.V570M|ENST00000409236,p.V545M|ENST00000356421,p.V570M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yvr.1	nonsynonymous SNV	exon15	c.G2092A	p.V698M	PRTANKAPGSKGVKQKSPPAAVAVA	PRTANKAPGSKGMKQKSPPAAVAVA	4.0	8.0	-	-	4160_2:100210490-100210490 C>T_PRTANKAPGSKGMKQKSPPAAVAVA	0.0
19:2934529-2934529 G>C	0.0	4078	GASTRIC	-	-	-	-	ZNF77	uc002lws.4,p.S199C|NM_021217,p.S199C|ENST00000314531,p.S199C	protein_coding, processed_transcript	uc002lws.4	nonsynonymous SNV	exon4	c.C596G	p.S199C	EKPCNCQDSRTASVTYVKSLSSKKS	EKPCNCQDSRTACVTYVKSLSSKKS	4.0	5.0	-	-	4078_19:2934529-2934529 G>C_EKPCNCQDSRTACVTYVKSLSSKKS	0.0
5:66055568-66055568 C>T	0.0	4326	BREAST	-	-	-	-	MAST4	ENST00000406374,p.P132L|uc021xzk.1,p.P132L|NM_001164664,p.P132L|ENST00000406039,p.P132L|NM_001290228,p.P132L|ENST00000403625,p.P132L|ENST00000404260,p.P132L|uc003jur.4,p.P132L|uc010iwz.3,p.P132L|NM_198828,p.P132L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xzk.1	nonsynonymous SNV	exon2	c.C395T	p.P132L	EELDHILSPPPMPFRKCSNPDVASG	EELDHILSPPPMLFRKCSNPDVASG	7.0	2.0	-	-	4326_5:66055568-66055568 C>T_EELDHILSPPPMLFRKCSNPDVASG	0.0
12:75434899-75434899 A>G	0.0	4278	COLORECTAL	-	-	-	-	KCNC2	uc009zry.4,p.L623P|NM_001260498,p.L623P|ENST00000341669,p.L623P|ENST00000550433,p.L623P	protein_coding, processed_transcript	uc009zry.4	nonsynonymous SNV	exon5	c.T1868C	p.L623P	EFSHTKDYTGNRLLLLNVP	EFSHTKDYTGNRPLLLNVP	3.0	2.0	-	-	4278_12:75434899-75434899 A>G_EFSHTKDYTGNRPLLLNVP	0.0
20:32295624-32295624 G>C	1.0	3466	MELANOMA	-	-	-	-	PXMP4	uc002wzv.3,p.S176C|ENST00000409299,p.S176C|NM_007238,p.S176C	protein_coding	uc002wzv.3	nonsynonymous SNV	exon4	c.C527G	p.S176C	WGLVLWLFEYHRSTLQPSLQSSMTY	WGLVLWLFEYHRCTLQPSLQSSMTY	6.0	6.0	CD8	-	3466_20:32295624-32295624 G>C_WGLVLWLFEYHRCTLQPSLQSSMTY	1.0
10:119100554-119100554 A>T	1.0	3466	MELANOMA	-	-	-	-	PDZD8	uc001lde.1,p.I311N|ENST00000334464,p.I311N|NM_173791,p.I311N	protein_coding, processed_transcript	uc001lde.1	nonsynonymous SNV	exon2	c.T932A	p.I311N	QTLQGFEEDEEHIHIQQWALTEGRL	QTLQGFEEDEEHNHIQQWALTEGRL	9.0	5.0	CD8	-	3466_10:119100554-119100554 A>T_QTLQGFEEDEEHNHIQQWALTEGRL	1.0
6:71570033-71570033 A>T	1.0	4000	MELANOMA	-	-	-	-	SMAP1	NM_001281440,p.K457I|uc010kap.3,p.K457I|ENST00000316999,p.K440I|uc003pfr.3,p.K467I|uc003pfs.3,p.K440I|NM_021940,p.K440I|ENST00000370455,p.K467I|NM_001044305,p.K467I	protein_coding	uc010kap.3	nonsynonymous SNV	exon11	c.A1370T	p.K457I	SSSGQTLSTQLWK	SSSGQTLSTQLWI	8.0	2.0	-	-	4000_6:71570033-71570033 A>T_SSSGQTLSTQLWI	0.0
16:66839834-66839834 C>G	0.0	4237	NSCLC	-	-	-	-	NAE1	uc002eqg.3,p.D387H|ENST00000379463,p.D470H|ENST00000290810,p.D476H|uc002eqf.3,p.D476H|NM_001018159,p.D470H|uc010cdv.3,p.D479H|NM_003905,p.D476H|uc002eqe.3,p.D470H|NM_001018160,p.D387H|ENST00000394074,p.D387H|NM_001286500,p.D479H|ENST00000359087,p.D479H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cdv.3	nonsynonymous SNV	exon18	c.G1435C	p.D479H	FLQEYGLSVMVKDDYVHEFCRYGAA	FLQEYGLSVMVKHDYVHEFCRYGAA	8.0	10.0	-	-	4237_16:66839834-66839834 C>G_FLQEYGLSVMVKHDYVHEFCRYGAA	0.0
10:101590067-101590067 A>G	0.0	4234	NSCLC	-	-	ID=COSM199838;OCCURENCE=1(large_intestine)	-	ABCC2	ENST00000370449,p.H875R|NM_000392,p.H875R|uc001kqf.2,p.H875R	protein_coding, processed_transcript	uc001kqf.2	nonsynonymous SNV	exon20	c.A2624G	p.H875R	LRHTGPEEEATVHDGSEEEDDDYGL	LRHTGPEEEATVRDGSEEEDDDYGL	5.0	10.0	-	-	4234_10:101590067-101590067 A>G_LRHTGPEEEATVRDGSEEEDDDYGL	0.0
7:83739836-83739836 C>T	1.0	3795	MELANOMA	-	-	-	-	SEMA3A	uc003uhz.3,p.G135R|NM_006080,p.G135R|ENST00000265362,p.G135R|ENST00000436949,p.G135R|ENST00000420047,p.G135R	protein_coding, processed_transcript	uc003uhz.3	nonsynonymous SNV	exon4	c.G403A	p.G135R	AYNQTHLYACGTGAFHPICTYIEIG	AYNQTHLYACGTRAFHPICTYIEIG	10.0	4.0	-	-	3795_7:83739836-83739836 C>T_AYNQTHLYACGTRAFHPICTYIEIG	0.0
19:49132422-49132422 C>G	0.0	4245	COLORECTAL	-	-	-	-	SPHK2	NM_001243876,p.L247V|NM_001204159,p.L453V|NM_001204158,p.L394V|NM_001204160,p.L417V|ENST00000600537,p.L394V|uc002pjw.3,p.L515V|uc002pjt.3,p.L247V|ENST00000599748,p.L417V|uc010xzt.2,p.L394V|NM_020126,p.L453V|uc002pjr.3,p.L453V|ENST00000598088,p.L453V|ENST00000340932,p.L415V|ENST00000245222,p.L453V|uc002pjv.3,p.L417V|ENST00000443164,p.L515V|ENST00000599029,p.L417V|uc002pjs.3,p.L453V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc010xzt.2	nonsynonymous SNV	exon7	c.C1180G	p.L394V	LPILSLNGGGPELAGDWGGAGDAPL	LPILSLNGGGPEVAGDWGGAGDAPL	7.0	6.0	-	-	4245_19:49132422-49132422 C>G_LPILSLNGGGPEVAGDWGGAGDAPL	0.0
13:76397747-76397747 G>A	1.0	3713	MELANOMA	-	-	-	-	LMO7	ENST00000341547,p.R614K|uc010thw.2,p.R513K|ENST00000377534,p.R948K|uc001vjw.1,p.R569K|ENST00000526202,p.R513K|ENST00000357063,p.R948K|uc021rkq.1,p.R896K|NM_005358,p.R614K|uc010thv.2,p.R614K|ENST00000377499,p.R562K|ENST00000465261,p.R663K|uc001vjt.1,p.R562K|NM_015842,p.R663K|ENST00000321797,p.R663K|uc001vjv.3,p.R663K	retained_intron, protein_coding, processed_transcript	uc021rkq.1	nonsynonymous SNV	exon15	c.G2687A	p.R896K	AWKYNGDVEDIKRTPNNVVSTPAPS	AWKYNGDVEDIKKTPNNVVSTPAPS	5.0	8.0	-	-	3713_13:76397747-76397747 G>A_AWKYNGDVEDIKKTPNNVVSTPAPS	0.0
10:83637750-83637750 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM1474824;OCCURENCE=1(breast)	-	NRG3	NM_001165973,p.V12I|uc021pvd.1,p.V12I|uc001kcp.2,p.V12I|ENST00000372142,p.V12I	protein_coding, nonsense_mediated_decay	uc021pvd.1	nonsynonymous SNV	exon1	c.G34A	p.V12I	MECGIPPTLVCVGRGGGLHTINII	MECGIPPTLVCIGRGGGLHTINII	3.0	1.0	-	-	4284_10:83637750-83637750 G>A_MECGIPPTLVCIGRGGGLHTINII	0.0
1:196397380-196397380 A>G	0.0	4259	COLORECTAL	-	-	-	-	KCNT2	uc009wyv.1,p.L255S|uc009wyu.3,p.L280S|uc001gte.1,p.L280S|ENST00000367433,p.L280S|ENST00000294725,p.L280S|uc001gtf.1,p.L280S|NM_001287819,p.L280S|ENST00000367431,p.L280S|NM_001287820,p.L280S|uc001gtd.1,p.L280S|NM_198503,p.L280S	protein_coding, processed_transcript	uc009wyv.1	nonsynonymous SNV	exon9	c.T764C	p.L255S	VVLPIQFEQLAYLWMERQKSGGNYS	VVLPIQFEQLAYSWMERQKSGGNYS	4.0	9.0	-	-	4259_1:196397380-196397380 A>G_VVLPIQFEQLAYSWMERQKSGGNYS	0.0
14:20874556-20874556 G>A	1.0	3713	MELANOMA	-	-	-	-	TEP1	ENST00000556935,p.R191C|uc001vxe.3,p.R191C|ENST00000555727,p.R191C|NM_007110,p.R191C|ENST00000262715,p.R191C|uc010tlg.1,p.R191C	retained_intron, protein_coding, nonsense_mediated_decay	uc010tlg.1	nonsynonymous SNV	exon3	c.C571T	p.R191C	SATETAQEATLGRWFDSEEKKGAET	SATETAQEATLGCWFDSEEKKGAET	9.0	8.0	-	-	3713_14:20874556-20874556 G>A_SATETAQEATLGCWFDSEEKKGAET	0.0
8:23159556-23159556 C>T	1.0	3713	MELANOMA	-	-	-	-	LOXL2	uc003xdh.1,p.G706E|ENST00000389131,p.G706E|NM_002318,p.G706E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xdh.1	nonsynonymous SNV	exon12	c.G2117A	p.G706E	DCQWVDITDVPPGDYLFQVVINPNF	DCQWVDITDVPPEDYLFQVVINPNF	6.0	4.0	-	-	3713_8:23159556-23159556 C>T_DCQWVDITDVPPEDYLFQVVINPNF	0.0
7:4051785-4051785 C>T	0.0	4266	COLORECTAL	-	-	ID=COSM1450671;OCCURENCE=1(large_intestine)	-	SDK1	ENST00000404826,p.R780W|uc003smx.3,p.R780W|ENST00000389531,p.R780W|uc010kso.3,p.R56W|NM_152744,p.R780W	retained_intron, protein_coding, processed_transcript	uc010kso.3	nonsynonymous SNV	exon2	c.C166T	p.R56W	PSAPPKNIVASGRTNQSIMVQWQPP	PSAPPKNIVASGWTNQSIMVQWQPP	5.0	9.0	-	-	4266_7:4051785-4051785 C>T_PSAPPKNIVASGWTNQSIMVQWQPP	0.0
19:52538108-52538108 C>T	1.0	4320	COLORECTAL	-	-	-	-	ZNF432	NM_014650,p.R275H|ENST00000221315,p.R275H|ENST00000594154,p.R275H|uc002pyk.3,p.R275H	protein_coding, processed_transcript	uc002pyk.3	nonsynonymous SNV	exon5	c.G824A	p.R275H	CSECGKVFTMKSRLIEHQRTHTGEK	CSECGKVFTMKSHLIEHQRTHTGEK	6.0	9.0	-	-	4320_19:52538108-52538108 C>T_CSECGKVFTMKSHLIEHQRTHTGEK	0.0
6:31543648-31543648 G>A	0.0	4238	COLORECTAL	-	-	-	-	TNF	NM_000594,p.A44T|ENST00000449264,p.A44T|uc003nui.4,p.A44T	protein_coding	uc003nui.4	nonsynonymous SNV	exon1	c.G130A	p.A44T	FLSLFSFLIVAGATTLFCLLHFGVI	FLSLFSFLIVAGTTTLFCLLHFGVI	1.0	8.0	-	-	4238_6:31543648-31543648 G>A_FLSLFSFLIVAGTTTLFCLLHFGVI	0.0
1:86951039-86951039 G>A	0.0	4110	BILE DUCT	-	-	-	-	CLCA1	uc001dls.1,p.C189Y|NM_001285,p.C250Y|uc001dlt.3,p.C250Y|ENST00000234701,p.C250Y|ENST00000394711,p.C250Y	protein_coding, processed_transcript	uc001dlt.3	nonsynonymous SNV	exon6	c.G749A	p.C250Y	MFAQHVDSIVEFCTEQNHNKEAPNK	MFAQHVDSIVEFYTEQNHNKEAPNK	1.0	7.0	-	-	4110_1:86951039-86951039 G>A_MFAQHVDSIVEFYTEQNHNKEAPNK	0.0
11:68179073-68179073 T>C	1.0	4180	BREAST	-	-	-	-	LRP5	uc001ont.3,p.S830P|NM_002335,p.S830P|NM_001291902,p.S249P|ENST00000294304,p.S830P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ont.3	nonsynonymous SNV	exon11	c.T2488C	p.S830P	LYWTDLDTNMIESSNMLGQERVVIA	LYWTDLDTNMIEPSNMLGQERVVIA	9.0	9.0	-	-	4180_11:68179073-68179073 T>C_LYWTDLDTNMIEPSNMLGQERVVIA	0.0
12:12974979-12974979 G>A	1.0	4284	COLORECTAL	-	-	-	-	DDX47	ENST00000352940,p.E175K|ENST00000544400,p.E112K|ENST00000358007,p.E175K|uc001rax.3,p.E175K|uc009zhw.1,p.E175K|uc001rav.3,p.E175K|NM_201224,p.E175K|uc001ray.3,p.E175K|NM_016355,p.E175K	retained_intron, protein_coding, processed_transcript	uc009zhw.1	nonsynonymous SNV	exon5	c.G523A	p.E175K	FNLRALKYLVMDEADRILNMDFETE	FNLRALKYLVMDKADRILNMDFETE	10.0	4.0	-	-	4284_12:12974979-12974979 G>A_FNLRALKYLVMDKADRILNMDFETE	0.0
3:49744236-49744236 C>T	1.0	2369	MELANOMA	-	-	-	-	RNF123	NM_022064,p.L801F|ENST00000432042,p.L655F|ENST00000327697,p.L801F|uc003cxh.4,p.L801F|uc010hky.1,p.L463F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010hky.1	nonsynonymous SNV	exon16	c.C1387T	p.L463F	KLRRCPKRRKDILAELTKSQKVFSE	KLRRCPKRRKDIFAELTKSQKVFSE	9.0	5.0	-	-	2369_3:49744236-49744236 C>T_KLRRCPKRRKDIFAELTKSQKVFSE	0.0
1:182798035-182798035 G>T	0.0	3795	MELANOMA	-	-	-	-	NPL	NM_001200050,p.G300C|ENST00000367553,p.G319C|ENST00000367554,p.G300C|ENST00000258317,p.G319C|NM_030769,p.G319C|uc001gpo.2,p.G300C|uc009wyb.3,p.G319C	protein_coding, processed_transcript	uc009wyb.3	nonsynonymous SNV	exon13	c.G955T	p.G319C	SFTDLKDGNLEAGS	SFTDLKDGNLEACS	8.0	1.0	-	-	3795_1:182798035-182798035 G>T_SFTDLKDGNLEACS	0.0
8:72754928-72754928 C>T	1.0	4278	COLORECTAL	-	-	-	-	MSC	NM_005098,p.A197T|ENST00000325509,p.A197T|uc003xyx.1,p.A197T	protein_coding, processed_transcript	uc003xyx.1	nonsynonymous SNV	exon2	c.G589A	p.A197T	SGRPDSDTKEVSAANRLCGTTA	SGRPDSDTKEVSTANRLCGTTA	4.0	2.0	-	-	4278_8:72754928-72754928 C>T_SGRPDSDTKEVSTANRLCGTTA	0.0
1:173916575-173916575 T>C	0.0	4158	COLORECTAL	-	-	-	-	RC3H1	uc010pms.2,p.Y890C|NM_001300852,p.Y890C|NM_001300851,p.Y890C|ENST00000258349,p.Y890C|ENST00000367696,p.Y890C|NM_172071,p.Y890C|ENST00000367694,p.Y890C|uc010pmt.2,p.Y890C|uc001gjv.3,p.Y890C|uc001gju.4,p.Y890C|NM_001300850,p.Y890C	retained_intron, protein_coding	uc010pmt.2	nonsynonymous SNV	exon14	c.A2669G	p.Y890C	RFGAISRTSKTIYQGAGPMQAMAPQ	RFGAISRTSKTICQGAGPMQAMAPQ	7.0	5.0	-	-	4158_1:173916575-173916575 T>C_RFGAISRTSKTICQGAGPMQAMAPQ	0.0
18:907749-907749 C>T	0.0	4275	COLORECTAL	-	-	-	-	ADCYAP1	uc010dkg.3,p.A67V|NM_001099733,p.A67V|NM_001117,p.A67V|ENST00000579794,p.A67V|ENST00000450565,p.A67V|uc010dkh.4,p.A67V	retained_intron, protein_coding	uc010dkh.4	nonsynonymous SNV	exon2	c.C200T	p.A67V	GSEPPGAGSPASAPRAAAAWYRPAG	GSEPPGAGSPASVPRAAAAWYRPAG	2.0	10.0	-	-	4275_18:907749-907749 C>T_GSEPPGAGSPASVPRAAAAWYRPAG	0.0
2:216251523-216251523 G>A	1.0	2591	MELANOMA	-	-	-	-	FN1	ENST00000354785,p.R1501W|ENST00000456923,p.R217W|NM_002026,p.R1410W|uc010zjp.2,p.R128W|ENST00000359671,p.R1410W|NM_212476,p.R1410W|ENST00000357867,p.R1410W|uc002vfb.3,p.R1410W|ENST00000345488,p.R1410W|ENST00000446046,p.R1410W|ENST00000421182,p.R1410W|ENST00000357009,p.R1410W|uc002vfi.3,p.R1501W|uc002vfe.3,p.R1410W|NM_212482,p.R1501W|NM_212474,p.R1410W|uc002vfa.3,p.R1501W|NM_212478,p.R1410W|ENST00000443816,p.R1410W|uc002vfc.3,p.R1410W|uc002vfg.3,p.R1410W|uc002vfh.3,p.R1410W|uc002vfj.3,p.R1501W|uc002vff.3,p.R1410W|ENST00000336916,p.R1410W|ENST00000323926,p.R1501W|ENST00000356005,p.R1410W|ENST00000432072,p.R1501W|ENST00000346544,p.R1410W	retained_intron, protein_coding, processed_transcript	uc010zjp.2	nonsynonymous SNV	exon4	c.C382T	p.R128W	SGRPREDRVPHSRNSITLTNLTPGT	SGRPREDRVPHSWNSITLTNLTPGT	10.0	4.0	-	-	2591_2:216251523-216251523 G>A_SGRPREDRVPHSWNSITLTNLTPGT	0.0
17:57676116-57676116 A>C	1.0	4335	COLORECTAL	-	-	-	-	DHX40	uc002ixn.2,p.K534T|NM_024612,p.K534T|ENST00000451169,p.K486T|NM_001166301,p.K457T|uc010woe.2,p.K457T|ENST00000425628,p.K457T|ENST00000251241,p.K534T|uc010wof.2,p.K49T	retained_intron, protein_coding, nonsense_mediated_decay	uc010wof.2	nonsynonymous SNV	exon2	c.A146C	p.K49T	NVFIRPVDPEYQKEAEQRHRELAAK	NVFIRPVDPEYQTEAEQRHRELAAK	8.0	5.0	-	-	4335_17:57676116-57676116 A>C_NVFIRPVDPEYQTEAEQRHRELAAK	0.0
X:134125217-134125217 G>A	0.0	4316	COLORECTAL	-	-	-	-	SMIM10	ENST00000330288,p.R31H|uc011mvs.2,p.R31H|NM_001163438,p.R31H	protein_coding	uc011mvs.2	nonsynonymous SNV	exon1	c.G92A	p.R31H	AAALSGLAVRLSRPQGTRGSYGAFC	AAALSGLAVRLSHPQGTRGSYGAFC	1.0	7.0	-	-	4316_X:134125217-134125217 G>A_AAALSGLAVRLSHPQGTRGSYGAFC	0.0
19:18779361-18779361 G>A	0.0	4278	COLORECTAL	-	-	-	-	KLHL26	NM_018316,p.R385H|uc002njz.1,p.R385H|ENST00000300976,p.R385H	protein_coding, processed_transcript, nonsense_mediated_decay	uc002njz.1	nonsynonymous SNV	exon3	c.G1154A	p.R385H	YRSGEGAVDACYRYDPHLNRWLRLQ	YRSGEGAVDACYHYDPHLNRWLRLQ	5.0	7.0	-	-	4278_19:18779361-18779361 G>A_YRSGEGAVDACYHYDPHLNRWLRLQ	0.0
10:111624956-111624956 A>T	1.0	3678	MELANOMA	-	-	-	-	XPNPEP1	uc001kyp.2,p.S663T|uc009xxt.2,p.S639T|NM_020383,p.S663T|ENST00000322238,p.S639T|ENST00000369683,p.S549T|NM_001167604,p.S639T|ENST00000502935,p.S663T|ENST00000369680,p.S620T|uc001kyq.2,p.S549T	retained_intron, protein_coding, processed_transcript	uc009xxt.2	nonsynonymous SNV	exon20	c.T1915A	p.S639T	ALEWLIRETQPISKQH	ALEWLIRETQPITKQH	9.0	9.0	CD8	-	3678_10:111624956-111624956 A>T_ALEWLIRETQPITKQH	1.0
21:47349844-47349844 T>G	0.0	4246	COLORECTAL	-	-	-	-	PCBP3	ENST00000400308,p.L218R|NM_001130141,p.L218R|ENST00000400309,p.L243R|ENST00000400304,p.L234R|uc002zht.2,p.L234R|uc002zhs.2,p.L218R	retained_intron, protein_coding, processed_transcript	uc002zht.2	nonsynonymous SNV	exon9	c.T701G	p.L234R	GQYAIPHPDLTKLHQLAMQQTPFPP	GQYAIPHPDLTKRHQLAMQQTPFPP	3.0	2.0	-	-	4246_21:47349844-47349844 T>G_GQYAIPHPDLTKRHQLAMQQTPFPP	0.0
2:72406588-72406588 A>C	1.0	3879	MELANOMA	-	-	-	-	EXOC6B	ENST00000272427,p.M771R|uc010fep.3,p.M771R|NM_015189,p.M771R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010fep.3	nonsynonymous SNV	exon22	c.T2312G	p.M771R	VNPVTALTLLEKMKDTSRKNNMFAQ	VNPVTALTLLEKRKDTSRKNNMFAQ	8.0	4.0	-	-	3879_2:72406588-72406588 A>C_VNPVTALTLLEKRKDTSRKNNMFAQ	0.0
13:24242922-24242922 A>C	0.0	4259	COLORECTAL	-	-	-	-	TNFRSF19	NM_018647,p.M311L|ENST00000403372,p.M179L|ENST00000248484,p.M311L|NM_148957,p.M311L|uc010tcu.2,p.M179L|uc001uot.3,p.M311L|NM_001204459,p.M179L|uc001uow.3,p.M311L|uc001uov.2,p.M311L|NM_001204458,p.M311L|ENST00000382258,p.M311L|ENST00000382263,p.M311L	protein_coding, processed_transcript	uc010tcu.2	nonsynonymous SNV	exon7	c.A535C	p.M179L	SICGEFSDAWPLMQNPMGGDNISFC	SICGEFSDAWPLLQNPMGGDNISFC	7.0	3.0	-	-	4259_13:24242922-24242922 A>C_SICGEFSDAWPLLQNPMGGDNISFC	0.0
5:14368832-14368832 G>A	1.0	4078	GASTRIC	-	-	-	-	TRIO	uc011cna.1,p.A915T|ENST00000512070,p.A905T|ENST00000513206,p.A697T|ENST00000344204,p.A964T|uc003jff.3,p.A964T|NM_007118,p.A964T|uc003jfh.1,p.A613T|ENST00000509967,p.A915T|ENST00000537187,p.A964T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cna.1	nonsynonymous SNV	exon17	c.G2743A	p.A915T	QFQHAIEKTHQSALQVQQKAEAMLQ	QFQHAIEKTHQSTLQVQQKAEAMLQ	10.0	5.0	-	-	4078_5:14368832-14368832 G>A_QFQHAIEKTHQSTLQVQQKAEAMLQ	0.0
4:20544117-20544117 G>A	1.0	3784	MELANOMA	-	-	ID=COSM1694187;OCCURENCE=1(skin)	-	SLIT2	uc003gps.1,p.G707E|ENST00000273739,p.G719E|ENST00000503823,p.G707E|NM_001289135,p.G711E|NM_004787,p.G715E|ENST00000503837,p.G711E|ENST00000504154,p.G715E|uc003gpr.1,p.G715E|NM_001289136,p.G707E	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon20	c.G2120A	p.G707E	QDVAIQDFTCDDGNDDNSCSPLSRC	QDVAIQDFTCDDENDDNSCSPLSRC	7.0	5.0	-	-	3784_4:20544117-20544117 G>A_QDVAIQDFTCDDENDDNSCSPLSRC	0.0
11:121016634-121016634 C>T	1.0	3678	MELANOMA	-	-	-	-	TECTA	ENST00000392793,p.P1305L|uc010rzo.2,p.P1305L|NM_005422,p.P1305L|ENST00000264037,p.P1305L	protein_coding, processed_transcript	uc010rzo.2	nonsynonymous SNV	exon11	c.C3914T	p.P1305L	GFSKVQQLCSLIPNQNAAFSKCHSK	GFSKVQQLCSLILNQNAAFSKCHSK	3.0	4.0	-	-	3678_11:121016634-121016634 C>T_GFSKVQQLCSLILNQNAAFSKCHSK	0.0
1:222742860-222742860 C>A	1.0	4234	NSCLC	-	-	-	-	TAF1A	ENST00000350027,p.V296L|NM_005681,p.V296L|NM_001201536,p.V296L|NM_139352,p.V182L|ENST00000366890,p.V182L|ENST00000391883,p.V258L|uc001hnj.3,p.V296L|ENST00000352967,p.V296L|ENST00000391882,p.V182L|uc009xdz.2,p.V296L|uc001hni.2,p.V182L	protein_coding, processed_transcript	uc009xdz.2	nonsynonymous SNV	exon7	c.G886T	p.V296L	KRQKAPRSKLISVLKILYQIVPSHK	KRQKAPRSKLISLLKILYQIVPSHK	7.0	1.0	-	-	4234_1:222742860-222742860 C>A_KRQKAPRSKLISLLKILYQIVPSHK	0.0
16:2278454-2278454 A>G	0.0	4316	COLORECTAL	-	-	-	-	E4F1	uc010bsj.3,p.K80R|NM_001288776,p.K80R|ENST00000564139,p.K80R|uc002cpm.3,p.K80R|ENST00000565090,p.K80R|uc010bsi.3,p.K80R|ENST00000565413,p.K58R|NM_001288778,p.K80R|NM_004424,p.K80R|ENST00000301727,p.K80R	retained_intron, protein_coding, nonsense_mediated_decay	uc010bsj.3	nonsynonymous SNV	exon2	c.A239G	p.K80R	TALEDFVQHKIQKACQRAPPEALPA	TALEDFVQHKIQRACQRAPPEALPA	7.0	2.0	-	-	4316_16:2278454-2278454 A>G_TALEDFVQHKIQRACQRAPPEALPA	0.0
14:105179863-105179863 G>A	1.0	4244	COLORECTAL	-	-	-	-	INF2	ENST00000392634,p.R987Q|uc001ypb.2,p.R987Q|NM_001031714,p.R987Q|ENST00000330634,p.R987Q|uc001ypc.2,p.R987Q|NM_022489,p.R987Q|ENST00000252527,p.R455Q	retained_intron, protein_coding, nonsense_mediated_decay	uc001ypc.2	nonsynonymous SNV	exon20	c.G2960A	p.R987Q	ALLADIRKGFQLRKTARGRGDTDGG	ALLADIRKGFQLQKTARGRGDTDGG	10.0	4.0	-	-	4244_14:105179863-105179863 G>A_ALLADIRKGFQLQKTARGRGDTDGG	0.0
19:36278433-36278433 C>T	1.0	4317	COLORECTAL	0.0005	-	-	-	ARHGAP33	ENST00000007510,p.S989L|ENST00000314737,p.S828L|uc002obs.2,p.S828L|uc002obv.1,p.S577L|NM_052948,p.S828L	retained_intron, protein_coding, processed_transcript	uc002obv.1	nonsynonymous SNV	exon8	c.C1730T	p.S577L	GSLLRSQRPMGTSRRGLRGPAQVSA	GSLLRSQRPMGTLRRGLRGPAQVSA	9.0	7.0	-	-	4317_19:36278433-36278433 C>T_GSLLRSQRPMGTLRRGLRGPAQVSA	0.0
2:109746315-109746315 G>A	0.0	4235	COLORECTAL	-	-	-	-	SH3RF3	ENST00000309415,p.E107K|ENST00000418513,p.E107K|uc010ywt.1,p.E107K|NM_001099289,p.E107K	protein_coding	uc010ywt.1	nonsynonymous SNV	exon1	c.G319A	p.E107K	PECRILVGCGVDELPANILLVRLLD	PECRILVGCGVDKLPANILLVRLLD	4.0	6.0	-	-	4235_2:109746315-109746315 G>A_PECRILVGCGVDKLPANILLVRLLD	0.0
9:94809535-94809535 C>G	0.0	4345	COLORECTAL	-	-	-	-	SPTLC1	uc004arl.1,p.G334R|NM_001281303,p.G334R|NM_006415,p.G334R|ENST00000262554,p.G334R|uc011ltv.1,p.G334R	protein_coding, processed_transcript	uc011ltv.1	nonsynonymous SNV	exon11	c.G1000C	p.G334R	SFVIDHQRLSGQGYCFSASLPPLLA	SFVIDHQRLSGQRYCFSASLPPLLA	10.0	8.0	-	-	4345_9:94809535-94809535 C>G_SFVIDHQRLSGQRYCFSASLPPLLA	0.0
14:23588135-23588135 C>T	0.0	4037	NSCLC	-	-	-	-	CEBPE	uc001wiv.2,p.D56N|NM_001805,p.D56N|ENST00000206513,p.D56N	protein_coding	uc001wiv.2	nonsynonymous SNV	exon1	c.G166A	p.D56N	AYIESGEEQLLSDLFAVKPAPEARG	AYIESGEEQLLSNLFAVKPAPEARG	1.0	10.0	-	-	4037_14:23588135-23588135 C>T_AYIESGEEQLLSNLFAVKPAPEARG	0.0
3:124807192-124807192 A>T	1.0	3466	MELANOMA	-	-	-	-	SLC12A8	uc003ehv.4,p.F648L|ENST00000430155,p.F449L|ENST00000393469,p.F648L|uc003ehw.4,p.F677L|NM_024628,p.F648L|NM_001195483,p.F648L|ENST00000423114,p.F677L|ENST00000469902,p.F648L|uc003eht.4,p.F449L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ehw.4	nonsynonymous SNV	exon13	c.T2031A	p.F677L	PGLHLGSASNFSFFRWMRSLLLPSC	PGLHLGSASNFSLFRWMRSLLLPSC	3.0	5.0	-	-	3466_3:124807192-124807192 A>T_PGLHLGSASNFSLFRWMRSLLLPSC	0.0
15:99901588-99901588 C>T	1.0	3466	MELANOMA	-	-	-	-	LRRC28	ENST00000301981,p.S248L|ENST00000558172,p.S144L|uc002bvb.1,p.S94L|uc010urt.1,p.S62L|NM_001284400,p.S248L|uc010uru.1,p.S179L|uc002bva.1,p.S248L|NM_144598,p.S248L|ENST00000422500,p.S179L|uc002bvc.1,p.S248L|ENST00000447360,p.S248L|ENST00000561276,p.S203L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uru.1	nonsynonymous SNV	exon7	c.C536T	p.S179L	PIQVSEVKLLSFSSGQRTVFLPAEV	PIQVSEVKLLSFLSGQRTVFLPAEV	6.0	8.0	-	-	3466_15:99901588-99901588 C>T_PIQVSEVKLLSFLSGQRTVFLPAEV	0.0
8:139165408-139165408 G>T	0.0	4196	COLORECTAL	-	-	-	2	FAM135B	uc003yuy.3,p.T437K|NM_015912,p.T437K|uc003yux.3,p.T338K|ENST00000276737,p.T437K|ENST00000395297,p.T437K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003yuy.3	nonsynonymous SNV	exon13	c.C1310A	p.T437K	VYPNFDVPVTSPTIMNLKDKEDNCM	VYPNFDVPVTSPKIMNLKDKEDNCM	3.0	10.0	-	-	4196_8:139165408-139165408 G>T_VYPNFDVPVTSPKIMNLKDKEDNCM	0.0
2:61475772-61475772 T>C	1.0	4245	COLORECTAL	-	-	-	-	USP34	uc002sbe.3,p.R2090G|ENST00000398571,p.R2090G|ENST00000453734,p.R368G|uc002sbf.3,p.R240G|NM_014709,p.R2090G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002sbf.3	nonsynonymous SNV	exon11	c.A718G	p.R240G	KKLPRILSFNTMRYTFNMVTMMKEK	KKLPRILSFNTMGYTFNMVTMMKEK	9.0	1.0	-	-	4245_2:61475772-61475772 T>C_KKLPRILSFNTMGYTFNMVTMMKEK	0.0
19:42085967-42085967 A>G	0.0	4335	COLORECTAL	-	-	-	-	CEACAM21	ENST00000187608,p.K229R|NM_001290113,p.K101R|uc002org.4,p.K229R|NM_033543,p.K229R	protein_coding, processed_transcript, nonsense_mediated_decay	uc002org.4	nonsynonymous SNV	exon3	c.A686G	p.K229R	SNPVSSNRSDPLKLTVKYDNTLGIL	SNPVSSNRSDPLRLTVKYDNTLGIL	7.0	3.0	-	-	4335_19:42085967-42085967 A>G_SNPVSSNRSDPLRLTVKYDNTLGIL	0.0
12:2656637-2656637 T>G	0.0	4317	COLORECTAL	-	-	-	-	CACNA1C	ENST00000335762,p.L471R|uc001qkv.1,p.L16R	retained_intron, protein_coding, processed_transcript	uc001qkv.1	nonsynonymous SNV	exon3	c.T47G	p.L16R	EKPRNRGTPAGMLDQKKGKFAWFSH	EKPRNRGTPAGMRDQKKGKFAWFSH	8.0	3.0	-	-	4317_12:2656637-2656637 T>G_EKPRNRGTPAGMRDQKKGKFAWFSH	0.0
8:7807627-7807627 T>A	0.0	4284	COLORECTAL	-	-	-	-	ZNF705B	ENST00000443676,p.V71E|NM_001193630,p.V71E|uc010lro.1,p.V71E|ENST00000400120,p.V71E	protein_coding	uc010lro.1	nonsynonymous SNV	exon5	c.T212A	p.V71E	LEQGKELWWEGRVFLQDQNPDRESA	LEQGKELWWEGREFLQDQNPDRESA	3.0	6.0	-	-	4284_8:7807627-7807627 T>A_LEQGKELWWEGREFLQDQNPDRESA	0.0
1:186331420-186331420 C>A	1.0	4326	BREAST	-	-	-	1	TPR	uc010pop.2,p.E339D|ENST00000367478,p.E263D|NM_003292,p.E263D|uc001grv.3,p.E263D	retained_intron, protein_coding, processed_transcript	uc010pop.2	nonsynonymous SNV	exon8	c.G1017T	p.E339D	QKHVEDLLTKLKEAKEQQASMEEKF	QKHVEDLLTKLKDAKEQQASMEEKF	10.0	6.0	-	-	4326_1:186331420-186331420 C>A_QKHVEDLLTKLKDAKEQQASMEEKF	0.0
8:145665548-145665548 G>A	1.0	4000	MELANOMA	-	-	-	-	TONSL	NM_013432,p.P446S|ENST00000409379,p.P446S|uc011llg.2,p.P446S	retained_intron, protein_coding	uc011llg.2	nonsynonymous SNV	exon11	c.C1336T	p.P446S	LQHLHTVQLRLQPQEAPETETRLRE	LQHLHTVQLRLQSQEAPETETRLRE	6.0	10.0	-	-	4000_8:145665548-145665548 G>A_LQHLHTVQLRLQSQEAPETETRLRE	0.0
20:23545624-23545624 G>C	0.0	4095	COLORECTAL	-	-	-	-	CST9L	NM_080610,p.F135L|uc002wtk.4,p.F135L|ENST00000376979,p.F135L	protein_coding	uc002wtk.4	nonsynonymous SNV	exon3	c.C405G	p.F135L	FFTISTRPWMTQFSLLNKTCLEGFH	FFTISTRPWMTQLSLLNKTCLEGFH	1.0	6.0	-	-	4095_20:23545624-23545624 G>C_FFTISTRPWMTQLSLLNKTCLEGFH	0.0
1:26664847-26664847 T>C	0.0	4335	COLORECTAL	-	-	-	-	AIM1L	ENST00000527815,p.R282G|uc001bmd.4,p.R1156G|NM_001039775,p.R1156G|ENST00000308182,p.R111G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001bmd.4	nonsynonymous SNV	exon7	c.A3466G	p.R1156G	TSDPSVGSLKPMRLGCPSVEKPGEP	TSDPSVGSLKPMGLGCPSVEKPGEP	5.0	7.0	-	-	4335_1:26664847-26664847 T>C_TSDPSVGSLKPMGLGCPSVEKPGEP	0.0
3:55504434-55504434 G>A	0.0	4078	GASTRIC	-	-	-	-	WNT5A	uc003dhm.3,p.R262W|ENST00000264634,p.R277W|NM_001256105,p.R262W|uc010hmw.4,p.R262W|ENST00000474267,p.R277W|NM_003392,p.R277W|ENST00000497027,p.R262W|uc003dhn.4,p.R277W|uc010hmx.4,p.R188W	retained_intron, protein_coding, processed_transcript	uc010hmx.4	nonsynonymous SNV	exon5	c.C562T	p.R188W	ALKEKYDSAAAMRLNSRGKLVQVNS	ALKEKYDSAAAMWLNSRGKLVQVNS	5.0	3.0	-	-	4078_3:55504434-55504434 G>A_ALKEKYDSAAAMWLNSRGKLVQVNS	0.0
2:241622047-241622047 C>G	0.0	3775	CERVICAL	-	-	-	-	AQP12B	ENST00000407834,p.D70H|uc010fzj.3,p.D70H|NM_001102467,p.D70H	protein_coding, processed_transcript, nonsense_mediated_decay	uc010fzj.3	nonsynonymous SNV	exon1	c.G208C	p.D70H	VELGPWAGDFGPDLLLTLLFLLFLA	VELGPWAGDFGPHLLLTLLFLLFLA	1.0	7.0	-	-	3775_2:241622047-241622047 C>G_VELGPWAGDFGPHLLLTLLFLLFLA	0.0
19:50169965-50169965 G>A	1.0	4155	MELANOMA	-	-	-	2	BCL2L12	uc031rlw.1,p.E90K|uc031rma.1,p.E90K|NM_001282521,p.E90K|ENST00000246785,p.E90K|uc031rmd.1,p.E90K|uc031rlv.1,p.E90K|NM_138639,p.E90K|NM_001282517,p.E90K|uc031rlz.1,p.E90K|NM_001282520,p.E90K|NM_001282516,p.E90K|ENST00000441864,p.E90K|NM_001040668,p.E90K|uc031rlu.1,p.E90K|uc031rmb.1,p.E90K|NM_001282519,p.E90K|uc002ppb.3,p.E90K|uc002ppa.3,p.E90K|ENST00000598306,p.E27K|ENST00000246784,p.E90K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031rmd.1	nonsynonymous SNV	exon2	c.G268A	p.E90K	GPGPGASMAGSEELGLREDTLRVLA	GPGPGASMAGSEKLGLREDTLRVLA	8.0	6.0	-	-	4155_19:50169965-50169965 G>A_GPGPGASMAGSEKLGLREDTLRVLA	0.0
14:21873467-21873467 A>G	1.0	4335	COLORECTAL	-	-	-	-	CHD8	NM_001170629,p.S1070P|uc001wav.1,p.S233P|ENST00000430710,p.S791P|ENST00000557364,p.S1070P|ENST00000399982,p.S1070P|NM_020920,p.S791P|uc001was.2,p.S791P|uc001war.2,p.S1070P	retained_intron, protein_coding, processed_transcript	uc001wav.1	nonsynonymous SNV	exon6	c.T697C	p.S233P	KKYYRAILEKNFSFLSKGAGHTNMP	KKYYRAILEKNFPFLSKGAGHTNMP	9.0	2.0	-	-	4335_14:21873467-21873467 A>G_KKYYRAILEKNFPFLSKGAGHTNMP	0.0
16:30964795-30964795 A>C	1.0	4244	COLORECTAL	-	-	-	-	ORAI3	ENST00000318663,p.K173T|uc002eac.3,p.K173T|NM_152288,p.K173T|ENST00000566237,p.K173T	protein_coding, nonsense_mediated_decay	uc002eac.3	nonsynonymous SNV	exon2	c.A518C	p.K173T	LFLAEVVLVGWVKFVPIGAPLDTPT	LFLAEVVLVGWVTFVPIGAPLDTPT	8.0	5.0	-	-	4244_16:30964795-30964795 A>C_LFLAEVVLVGWVTFVPIGAPLDTPT	0.0
1:110153092-110153092 C>G	0.0	4252	COLORECTAL	-	-	-	-	GNAT2	ENST00000351050,p.Q52H|uc001dya.3,p.Q52H|NM_005272,p.Q52H	protein_coding	uc001dya.3	nonsynonymous SNV	exon2	c.G156C	p.Q52H	GAGESGKSTIVKQMKIIHQDGYSPE	GAGESGKSTIVKHMKIIHQDGYSPE	3.0	10.0	-	-	4252_1:110153092-110153092 C>G_GAGESGKSTIVKHMKIIHQDGYSPE	0.0
17:80382373-80382373 C>T	1.0	3998	MELANOMA	-	-	-	-	HEXDC	ENST00000337014,p.A63V|ENST00000577944,p.A63V|NM_173620,p.A63V|ENST00000327949,p.A63V|uc002kew.3,p.A63V|uc002kev.4,p.A63V|ENST00000578632,p.A16V	retained_intron, protein_coding, nonsense_mediated_decay	uc002kew.3	nonsynonymous SNV	exon2	c.C188T	p.A63V	YEGPLRLLRAKYAYSPSEIKEILHL	YEGPLRLLRAKYVYSPSEIKEILHL	8.0	4.0	-	-	3998_17:80382373-80382373 C>T_YEGPLRLLRAKYVYSPSEIKEILHL	0.0
20:368770-368770 C>T	1.0	3713	MELANOMA	-	-	-	-	TRIB3	ENST00000217233,p.P39L|NM_001301201,p.P66L|uc002wdm.3,p.P39L|NM_001301193,p.P39L|NM_001301188,p.P39L|uc002wdn.3,p.P66L|ENST00000449710,p.P39L|NM_021158,p.P39L|NM_001301190,p.P39L|NM_001301196,p.P39L|ENST00000422053,p.P66L	protein_coding, processed_transcript	uc002wdn.3	nonsynonymous SNV	exon3	c.C197T	p.P66L	TERPVQKRARSGPQPRLPPCLLPLS	TERPVQKRARSGLQPRLPPCLLPLS	6.0	6.0	-	-	3713_20:368770-368770 C>T_TERPVQKRARSGLQPRLPPCLLPLS	0.0
3:39185177-39185177 G>A	1.0	4213	COLORECTAL	-	-	-	-	CSRNP1	ENST00000273153,p.P380L|NM_033027,p.P380L|uc003cjh.3,p.P380L|uc003cjg.3,p.P380L|ENST00000514182,p.P380L	protein_coding	uc003cjh.3	nonsynonymous SNV	exon5	c.C1139T	p.P380L	APDCPTHPGLPGPGFQPGVDDDSLA	APDCPTHPGLPGLGFQPGVDDDSLA	7.0	4.0	-	-	4213_3:39185177-39185177 G>A_APDCPTHPGLPGLGFQPGVDDDSLA	0.0
2:165947051-165947051 C>T	0.0	4301	MELANOMA	-	-	ID=COSM39151;OCCURENCE=1(central_nervous_system)	-	SCN3A	NM_001081676,p.R1822Q|NM_001081677,p.R1822Q|uc002ucy.3,p.R1822Q|uc010zcy.2,p.R354Q|ENST00000283254,p.R1871Q|uc002ucx.3,p.R1871Q|ENST00000540861,p.R354Q|ENST00000409101,p.R1822Q|uc002ucz.3,p.R1822Q|ENST00000360093,p.R1871Q|NM_006922,p.R1871Q	retained_intron, protein_coding, processed_transcript	uc010zcy.2	nonsynonymous SNV	exon3	c.G1061A	p.R354Q	RVLGESGEMDALRIQMEDRFMASNP	RVLGESGEMDALQIQMEDRFMASNP	6.0	9.0	-	-	4301_2:165947051-165947051 C>T_RVLGESGEMDALQIQMEDRFMASNP	0.0
9:130570976-130570976 A>G	1.0	4252	COLORECTAL	-	-	-	-	FPGS	NM_004957,p.D321G|ENST00000373225,p.D271G|uc004bsh.1,p.D138G|NM_001288803,p.D295G|ENST00000393706,p.D295G|NM_001018078,p.D271G|uc004bsi.1,p.D271G|ENST00000373247,p.D321G|uc004bsg.1,p.D321G|uc011mal.1,p.D295G	protein_coding, processed_transcript	uc011mal.1	nonsynonymous SNV	exon9	c.A884G	p.D295G	ALQLAHCWLQRQDRHGAGEPKASRP	ALQLAHCWLQRQGRHGAGEPKASRP	10.0	1.0	-	-	4252_9:130570976-130570976 A>G_ALQLAHCWLQRQGRHGAGEPKASRP	0.0
10:61831113-61831113 C>T	0.0	3466	MELANOMA	-	-	-	-	ANK3	uc001jky.3,p.E3176K|NM_020987,p.E3176K|ENST00000280772,p.E3176K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001jky.3	nonsynonymous SNV	exon37	c.G9526A	p.E3176K	KSPLTPETPSSEEVSYEFTSKTPDS	KSPLTPETPSSEKVSYEFTSKTPDS	5.0	5.0	-	-	3466_10:61831113-61831113 C>T_KSPLTPETPSSEKVSYEFTSKTPDS	0.0
10:34671827-34671827 G>A	1.0	3713	MELANOMA	-	-	-	-	PARD3	uc001ixp.2,p.A347V|uc010qep.2,p.A303V|ENST00000545693,p.A347V|uc010qej.2,p.A347V|ENST00000350537,p.A347V|uc001ixo.2,p.A77V|NM_019619,p.A347V|ENST00000346874,p.A347V|NM_001184793,p.A347V|ENST00000374790,p.A303V|uc010qel.2,p.A347V|uc010qen.2,p.A347V|ENST00000544292,p.A77V|ENST00000340077,p.A347V|ENST00000545260,p.A303V|NM_001184790,p.A303V|ENST00000374773,p.A347V|uc010qeo.2,p.A347V|ENST00000374776,p.A347V|ENST00000374788,p.A347V|ENST00000374789,p.A347V|NM_001184785,p.A347V|uc001ixu.2,p.A303V|uc010qeq.2,p.A303V|uc001ixq.2,p.A347V|ENST00000374794,p.A303V|NM_001184791,p.A303V|NM_001184794,p.A347V|uc001ixr.2,p.A347V|uc010qek.2,p.A347V|NM_001184788,p.A347V|NM_001184792,p.A347V|NM_001184787,p.A347V|uc001ixt.1,p.A168V|NM_001184786,p.A347V|uc010qem.2,p.A347V|NM_001184789,p.A347V	protein_coding, processed_transcript	uc010qeq.2	nonsynonymous SNV	exon8	c.C908T	p.A303V	RRFEQAQHMFRQAMRTPIIWFHVVP	RRFEQAQHMFRQVMRTPIIWFHVVP	4.0	5.0	-	-	3713_10:34671827-34671827 G>A_RRFEQAQHMFRQVMRTPIIWFHVVP	0.0
3:122447408-122447408 A>C	1.0	4252	COLORECTAL	-	-	-	-	PARP14	NM_017554,p.Q1790H|uc003efq.4,p.Q1790H|uc003efr.3,p.Q1507H|ENST00000474629,p.Q1790H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003efr.3	nonsynonymous SNV	exon12	c.A4521C	p.Q1507H	HHPSLFVAFYDYQAYPEYLITFRK	HHPSLFVAFYDYHAYPEYLITFRK	8.0	2.0	-	-	4252_3:122447408-122447408 A>C_HHPSLFVAFYDYHAYPEYLITFRK	0.0
11:46693847-46693847 C>T	1.0	4252	COLORECTAL	-	-	-	-	ATG13	ENST00000529655,p.R470C|uc009yld.3,p.R507C|NM_001142673,p.R507C|NM_001205119,p.R540C|uc001ndb.3,p.R507C|ENST00000359513,p.R507C|NM_001205120,p.R507C|ENST00000530500,p.R391C|uc001ndc.3,p.R470C|ENST00000524625,p.R470C|ENST00000528494,p.R540C|uc010rgv.2,p.R391C|ENST00000312040,p.R507C|NM_001205122,p.R391C|ENST00000451945,p.R470C|NM_014741,p.R470C|uc001nda.3,p.R540C|ENST00000526508,p.R507C|uc001ncz.3,p.R470C|NM_001205121,p.R470C|ENST00000434074,p.R507C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rgv.2	nonsynonymous SNV	exon15	c.C1171T	p.R391C	LPEKLAVHEKNVREFDAFVETLQ	LPEKLAVHEKNVCEFDAFVETLQ	9.0	8.0	-	-	4252_11:46693847-46693847 C>T_LPEKLAVHEKNVCEFDAFVETLQ	0.0
18:9954180-9954180 G>T	1.0	4244	COLORECTAL	-	-	-	-	VAPA	ENST00000340541,p.G286V|uc002kok.3,p.G241V|uc002koj.3,p.G286V|NM_003574,p.G286V|NM_194434,p.G241V|ENST00000400000,p.G241V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kok.3	nonsynonymous SNV	exon6	c.G722T	p.G241V	PSLLVVIAAIFIGFFLGKFIL	PSLLVVIAAIFIVFFLGKFIL	10.0	10.0	CD8	-	4244_18:9954180-9954180 G>T_PSLLVVIAAIFIVFFLGKFIL	2.0
19:38230757-38230757 G>A	0.0	2369	MELANOMA	-	-	-	-	ZNF573	NM_001172691,p.H210Y|uc002ohf.3,p.H154Y|NM_001172692,p.H124Y|ENST00000536220,p.H124Y|uc021utv.1,p.H124Y|ENST00000357309,p.H124Y|NM_001172689,p.H124Y|uc002ohg.3,p.H124Y|ENST00000339503,p.H154Y|ENST00000392138,p.H125Y|uc010efs.2,p.H125Y|ENST00000590414,p.H212Y|uc002ohe.3,p.H212Y|uc002ohd.3,p.H210Y|NM_152360,p.H154Y|NM_001172690,p.H212Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc021utv.1	nonsynonymous SNV	exon4	c.C370T	p.H124Y	RSGYQLTVHQRFHTGEKTYECRQCG	RSGYQLTVHQRFYTGEKTYECRQCG	5.0	4.0	-	-	2369_19:38230757-38230757 G>A_RSGYQLTVHQRFYTGEKTYECRQCG	0.0
3:154861315-154861315 G>A	1.0	3879	MELANOMA	-	-	ID=COSM582160;OCCURENCE=1(lung)	-	MME	uc031scb.1,p.G91E	retained_intron, protein_coding, processed_transcript	uc031scb.1	nonsynonymous SNV	exon3	c.G272A	p.G91E	QTMSMGIWKMLWGGFMWKQHLLERV	QTMSMGIWKMLWEGFMWKQHLLERV	6.0	10.0	-	-	3879_3:154861315-154861315 G>A_QTMSMGIWKMLWEGFMWKQHLLERV	0.0
X:23724823-23724823 G>A	0.0	4081	COLORECTAL	-	-	ID=COSM457273;OCCURENCE=1(breast)	-	ACOT9	ENST00000336430,p.T246M|uc004dao.3,p.T255M|uc004dar.3,p.T186M|NM_001033583,p.T246M|ENST00000473710,p.T172M|uc004dap.3,p.T246M|ENST00000379303,p.T255M|ENST00000379295,p.T186M|NM_001037171,p.T255M	retained_intron, protein_coding, nonsense_mediated_decay	uc004dar.3	nonsynonymous SNV	exon9	c.C557T	p.T186M	ELNKGRRIAFSSTSLLKMAPSAEER	ELNKGRRIAFSSMSLLKMAPSAEER	6.0	7.0	-	-	4081_X:23724823-23724823 G>A_ELNKGRRIAFSSMSLLKMAPSAEER	0.0
8:85785574-85785574 A>C	0.0	4129	NSCLC	-	-	-	-	RALYL	NM_001100393,p.K209N|NM_001287243,p.K198N|ENST00000517638,p.K222N|NM_001100392,p.K209N|ENST00000521695,p.K209N|ENST00000523850,p.K136N|uc003ycr.4,p.K209N|NM_173848,p.K209N|uc003ycs.4,p.K209N|ENST00000521376,p.K120N|uc010lzy.3,p.K198N|NM_001100391,p.K222N|ENST00000521268,p.K209N|ENST00000518566,p.K198N|uc003yct.4,p.K222N|uc003ycu.4,p.K136N|ENST00000522455,p.K209N|NM_001287244,p.K136N|uc003ycq.4,p.K209N	retained_intron, protein_coding	uc010lzy.3	nonsynonymous SNV	exon6	c.A594C	p.K198N	QTIKKELTQIKTKIDSLLGRLEKIE	QTIKKELTQIKTNIDSLLGRLEKIE	1.0	8.0	-	-	4129_8:85785574-85785574 A>C_QTIKKELTQIKTNIDSLLGRLEKIE	0.0
2:25972692-25972692 G>T	1.0	4069	PANCREATIC	-	-	-	2	ASXL2	NM_018263,p.P578H|ENST00000404843,p.P318H|uc002rgt.1,p.P318H|uc002rgs.2,p.P578H|ENST00000272341,p.P318H|ENST00000435504,p.P578H|ENST00000336112,p.P550H	protein_coding, processed_transcript	uc002rgt.1	nonsynonymous SNV	exon8	c.C953A	p.P318H	LKRKSSLTQEEAPVSWEKRPRVTEN	LKRKSSLTQEEAHVSWEKRPRVTEN	8.0	9.0	-	-	4069_2:25972692-25972692 G>T_LKRKSSLTQEEAHVSWEKRPRVTEN	0.0
3:15292741-15292741 C>T	1.0	3903	MELANOMA	-	-	-	-	CAPN7	ENST00000253693,p.P806S|NM_014296,p.P806S|uc003bzn.3,p.P806S	retained_intron, protein_coding, nonsense_mediated_decay	uc003bzn.3	nonsynonymous SNV	exon21	c.C2416T	p.P806S	EGPFFLDFNSIIPIKITQLQ	EGPFFLDFNSIISIKITQLQ	7.0	2.0	-	-	3903_3:15292741-15292741 C>T_EGPFFLDFNSIISIKITQLQ	0.0
X:128692610-128692610 G>A	0.0	4158	COLORECTAL	-	-	-	-	OCRL	ENST00000371113,p.G147E|ENST00000357121,p.G147E|uc004euq.3,p.G147E|NM_000276,p.G147E|NM_001587,p.G147E|uc004eur.3,p.G147E	protein_coding, processed_transcript	uc004eur.3	nonsynonymous SNV	exon7	c.G440A	p.G147E	KLDTKDKPSVFSGLLGFEDNFSSMN	KLDTKDKPSVFSELLGFEDNFSSMN	5.0	9.0	-	-	4158_X:128692610-128692610 G>A_KLDTKDKPSVFSELLGFEDNFSSMN	0.0
7:82451994-82451994 G>A	1.0	3903	MELANOMA	-	-	-	-	PCLO	uc003uht.1,p.P312S|uc003uhu.1,p.P291S|uc003uhv.2,p.P4870S|NM_014510,p.P4870S|ENST00000333891,p.P4870S|ENST00000423517,p.P4870S|NM_033026,p.P4870S|uc003uhx.2,p.P4870S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003uhx.2	nonsynonymous SNV	exon20	c.C14608T	p.P4870S	GIFPDPSKDMQVPTIEKSHSSPGSS	GIFPDPSKDMQVSTIEKSHSSPGSS	5.0	10.0	-	-	3903_7:82451994-82451994 G>A_GIFPDPSKDMQVSTIEKSHSSPGSS	0.0
1:21071567-21071567 G>A	1.0	3713	MELANOMA	-	-	-	-	HP1BP3	uc001bdv.1,p.P424L|uc010odh.1,p.P424L|uc010odf.1,p.P121L|uc010odg.1,p.P310L|uc001bdy.1,p.P462L|uc001bdw.1,p.P462L|ENST00000312239,p.P462L|ENST00000375003,p.P310L|NM_016287,p.P462L	protein_coding, processed_transcript	uc010odh.1	nonsynonymous SNV	exon12	c.C1271T	p.P424L	EPPPKRRLQKKTPAKSPGKAASVKQ	EPPPKRRLQKKTLAKSPGKAASVKQ	10.0	6.0	-	-	3713_1:21071567-21071567 G>A_EPPPKRRLQKKTLAKSPGKAASVKQ	0.0
1:63282323-63282323 C>T	1.0	3879	MELANOMA	-	-	ID=COSM1474132,COSM1474133;OCCURENCE=1(breast)	-	ATG4C	ENST00000371118,p.R80C|NM_032852,p.R80C|ENST00000371120,p.R80C|NM_178221,p.R80C|ENST00000443289,p.R80C|uc001dau.3,p.R80C|ENST00000317868,p.R80C|uc001dat.3,p.R80C	protein_coding	uc001dau.3	nonsynonymous SNV	exon4	c.C238T	p.R80C	EDHVIAGNVEEFRKDFISRIWLTYR	EDHVIAGNVEEFCKDFISRIWLTYR	6.0	3.0	-	-	3879_1:63282323-63282323 C>T_EDHVIAGNVEEFCKDFISRIWLTYR	0.0
17:11583132-11583132 G>A	0.0	2591	MELANOMA	-	-	ID=COSM1709911;OCCURENCE=1(skin)	-	DNAH9	uc010coo.3,p.E432K|ENST00000454412,p.E1138K|NM_001372,p.E1138K|uc002gne.3,p.E1138K|ENST00000262442,p.E1138K	retained_intron, protein_coding, processed_transcript	uc010coo.3	nonsynonymous SNV	exon6	c.G1294A	p.E432K	IKKSESGLLKKVEKGDFQGLVEIMG	IKKSESGLLKKVKKGDFQGLVEIMG	1.0	4.0	-	-	2591_17:11583132-11583132 G>A_IKKSESGLLKKVKKGDFQGLVEIMG	0.0
7:99445222-99445222 G>A	0.0	3998	MELANOMA	0.0005	-	-	-	CYP3A43	ENST00000222382,p.E144K|NM_057095,p.E144K|NM_057096,p.E144K|ENST00000434806,p.E144K|uc003urx.1,p.E144K|ENST00000354829,p.E144K|ENST00000312017,p.E144K|uc003ury.1,p.E144K|NM_022820,p.E144K|uc003urz.1,p.E144K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003urz.1	nonsynonymous SNV	exon5	c.G430A	p.E144K	LLSPAFTSVKFKEMVPIISQCGDML	LLSPAFTSVKFKKMVPIISQCGDML	2.0	8.0	-	-	3998_7:99445222-99445222 G>A_LLSPAFTSVKFKKMVPIISQCGDML	0.0
12:81768465-81768465 G>A	0.0	4155	MELANOMA	-	-	-	-	PPFIA2	NM_001220478,p.T306I|NM_001220477,p.T331I|uc031qim.1,p.T405I|uc031qiu.1,p.T331I|ENST00000552948,p.T405I|NM_001220474,p.T387I|uc031qil.1,p.T306I|uc031qiq.1,p.T387I|uc031qin.1,p.T387I|NM_001282536,p.T252I|uc031qis.1,p.T405I|ENST00000407050,p.T331I|uc031qio.1,p.T405I|ENST00000443686,p.T306I|uc031qiw.1,p.T405I|uc031qiv.1,p.T306I|ENST00000548586,p.T405I|uc031qik.1,p.T331I|ENST00000550359,p.T252I|ENST00000550584,p.T405I|NM_001220476,p.T405I|uc031qiy.1,p.T405I|ENST00000549396,p.T405I|uc031qix.1,p.T405I|uc031qip.1,p.T405I|ENST00000333447,p.T387I|NM_001220475,p.T405I|ENST00000549325,p.T387I|NM_003625,p.T405I|NM_001220473,p.T405I|uc031qir.1,p.T405I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qiy.1	nonsynonymous SNV	exon9	c.C1214T	p.T405I	EQKLQQTMRKAETLPEVEAELAQRI	EQKLQQTMRKAEILPEVEAELAQRI	4.0	5.0	-	-	4155_12:81768465-81768465 G>A_EQKLQQTMRKAEILPEVEAELAQRI	0.0
21:37610932-37610932 G>A	1.0	4234	NSCLC	-	-	-	-	DOPEY2	uc002yvg.3,p.V937M|NM_005128,p.V937M|ENST00000399151,p.V937M	retained_intron, protein_coding, processed_transcript	uc002yvg.3	nonsynonymous SNV	exon17	c.G2809A	p.V937M	KGTRLEALFRFSVIWHLTREIQGSR	KGTRLEALFRFSMIWHLTREIQGSR	7.0	7.0	CD8	-	4234_21:37610932-37610932 G>A_KGTRLEALFRFSMIWHLTREIQGSR	2.0
3:140785271-140785271 C>T	0.0	4346	COLORECTAL	-	-	-	-	SPSB4	uc003ett.3,p.R109C|uc010hum.3,p.R109C|ENST00000310546,p.R109C|NM_080862,p.R109C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010hum.3	nonsynonymous SNV	exon1	c.C325T	p.R109C	LHAWQINWPARQRGTHAVVGVATAR	LHAWQINWPARQCGTHAVVGVATAR	1.0	6.0	-	-	4346_3:140785271-140785271 C>T_LHAWQINWPARQCGTHAVVGVATAR	0.0
7:44714065-44714065 G>T	1.0	4126	NSCLC	-	-	-	-	OGDH	uc011kby.2,p.G132C|ENST00000447398,p.G293C|uc011kbz.2,p.G77C|NM_002541,p.G282C|NM_001165036,p.G278C|NM_001003941,p.G282C|ENST00000444676,p.G297C|uc011kbx.2,p.G278C|ENST00000439616,p.G132C|ENST00000222673,p.G282C|ENST00000543843,p.G233C|uc003tln.3,p.G282C|uc003tlm.3,p.G282C|ENST00000449767,p.G278C|ENST00000443864,p.G282C|uc003tlp.3,p.G293C|uc003tlo.1,p.G115C	retained_intron, protein_coding, processed_transcript	uc011kbz.2	nonsynonymous SNV	exon5	c.G229T	p.G77C	RKWSSEKRFGLEGCEVLIPALKTII	RKWSSEKRFGLECCEVLIPALKTII	9.0	8.0	-	-	4126_7:44714065-44714065 G>T_RKWSSEKRFGLECCEVLIPALKTII	0.0
4:77976352-77976352 A>C	1.0	4037	NSCLC	-	-	-	-	CCNI	uc003hkm.3,p.L214R|NM_006835,p.L214R|ENST00000237654,p.L214R|uc011ccb.2,p.L200R|ENST00000537948,p.L200R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ccb.2	nonsynonymous SNV	exon5	c.T599G	p.L200R	LALAMVSLEMEKLIPDWLSLTIELL	LALAMVSLEMEKRIPDWLSLTIELL	10.0	7.0	-	-	4037_4:77976352-77976352 A>C_LALAMVSLEMEKRIPDWLSLTIELL	0.0
12:129190448-129190448 G>A	0.0	4301	MELANOMA	-	-	-	-	TMEM132C	ENST00000315208,p.E595K|ENST00000537538,p.E364K|ENST00000435159,p.E979K|uc021rgn.1,p.E979K|NM_001136103,p.E979K	protein_coding	uc021rgn.1	nonsynonymous SNV	exon9	c.G2935A	p.E979K	HSHDWVWLGNEAELLESMGDAPPPQ	HSHDWVWLGNEAKLLESMGDAPPPQ	5.0	6.0	-	-	4301_12:129190448-129190448 G>A_HSHDWVWLGNEAKLLESMGDAPPPQ	0.0
19:49489259-49489259 C>T	1.0	4287	COLORECTAL	-	-	-	-	GYS1	NM_002103,p.V176I|ENST00000541188,p.V96I|ENST00000323798,p.V176I|ENST00000540532,p.V96I|uc002plp.3,p.V176I|uc010xzz.2,p.V96I	retained_intron, protein_coding, processed_transcript	uc010xzz.2	nonsynonymous SNV	exon3	c.G286A	p.V96I	EFLAQSEEKPHVVAHFHEWLAGVGL	EFLAQSEEKPHVIAHFHEWLAGVGL	8.0	10.0	-	-	4287_19:49489259-49489259 C>T_EFLAQSEEKPHVIAHFHEWLAGVGL	0.0
19:16677428-16677428 T>G	1.0	4071	COLORECTAL	-	-	-	-	SLC35E1	ENST00000595753,p.N224T|NM_024881,p.N224T|ENST00000436553,p.N158T|uc002nem.1,p.N224T|ENST00000431408,p.N68T|uc010xph.2,p.N224T	 protein_coding, processed_transcript,retained_intron, nonsense_mediated_decay	uc010xph.2	nonsynonymous SNV	exon4	c.A671C	p.N224T	LRDSRIHHLRLLNILGCHAVFFMIP	LRDSRIHHLRLLTILGCHAVFFMIP	9.0	4.0	-	-	4071_19:16677428-16677428 T>G_LRDSRIHHLRLLTILGCHAVFFMIP	0.0
19:33904513-33904513 C>A	1.0	4129	NSCLC	-	-	-	-	PEPD	uc010xrr.2,p.M195I|ENST00000397032,p.M195I|NM_001166056,p.M195I	retained_intron, protein_coding, lincRNA	uc010xrr.2	nonsynonymous SNV	exon8	c.G585T	p.M195I	CLFEHYCYSRGGMRHSSYTCICGSG	CLFEHYCYSRGGIRHSSYTCICGSG	10.0	3.0	-	-	4129_19:33904513-33904513 C>A_CLFEHYCYSRGGIRHSSYTCICGSG	0.0
1:115256530-115256530 G>T	1.0	3795	MELANOMA	-	-	ID=COSM580;OCCURENCE=1(prostate),79(large_intestine),1(biliary_tract),2(urinary_tract),2(eye),1(kidney),2(liver),2(pancreas),2(breast),437(skin),2(endometrium),1(ovary),15(soft_tissue),5(autonomic_ganglia),2(cervix),71(haematopoietic_and_lymphoid_tissue),1(meninges),56(thyroid),18(lung),29(NS),4(bone),4(central_nervous_system),1(stomach)	1	NRAS	uc009wgu.3,p.Q61K|ENST00000369535,p.Q61K|NM_002524,p.Q61K	protein_coding	uc009wgu.3	nonsynonymous SNV	exon3	c.C181A	p.Q61K	ETCLLDILDTAGQEEYSAMRDQYMR	ETCLLDILDTAGKEEYSAMRDQYMR	9.0	8.0	CD8	-	3795_1:115256530-115256530 G>T_ETCLLDILDTAGKEEYSAMRDQYMR	1.0
19:53270609-53270609 G>A	1.0	4301	MELANOMA	-	-	-	-	ZNF600	uc021uyz.1,p.H134Y|ENST00000338230,p.H134Y|uc002qab.4,p.H134Y|NM_198457,p.H134Y	protein_coding, processed_transcript	uc021uyz.1	nonsynonymous SNV	exon1	c.C400T	p.H134Y	STSQRISPRPQIHISNNYGNNSPNS	STSQRISPRPQIYISNNYGNNSPNS	8.0	3.0	-	-	4301_19:53270609-53270609 G>A_STSQRISPRPQIYISNNYGNNSPNS	0.0
X:77912719-77912719 G>A	1.0	3713	MELANOMA	-	-	-	-	ZCCHC5	NM_152694,p.P400L|uc022bzi.1,p.P400L|uc004edc.1,p.P400L|ENST00000321110,p.P400L	protein_coding	uc022bzi.1	nonsynonymous SNV	exon1	c.C1199T	p.P400L	QCISLEEKPDPNPLGKSSSAEGDGP	QCISLEEKPDPNLLGKSSSAEGDGP	1.0	5.0	-	-	3713_X:77912719-77912719 G>A_QCISLEEKPDPNLLGKSSSAEGDGP	0.0
1:220826691-220826691 G>A	1.0	4037	NSCLC	-	-	-	-	MARK1	uc001hmn.4,p.R662H|ENST00000366917,p.R662H|NM_001286124,p.R663H|NM_018650,p.R662H|uc009xdw.3,p.R663H	protein_coding, processed_transcript	uc009xdw.3	nonsynonymous SNV	exon16	c.G1988A	p.R663H	TGIISKITSKFVRRDPSEGEASGRT	TGIISKITSKFVHRDPSEGEASGRT	6.0	10.0	-	-	4037_1:220826691-220826691 G>A_TGIISKITSKFVHRDPSEGEASGRT	0.0
10:103649225-103649225 G>A	1.0	3879	MELANOMA	-	-	-	-	C10orf76	ENST00000370033,p.P602S|uc009xwy.1,p.P602S|NM_024541,p.P602S	protein_coding, processed_transcript	uc009xwy.1	nonsynonymous SNV	exon24	c.C1804T	p.P602S	LVNIRAIINHFNPKIESYAAVNHIS	LVNIRAIINHFNSKIESYAAVNHIS	5.0	7.0	-	-	3879_10:103649225-103649225 G>A_LVNIRAIINHFNSKIESYAAVNHIS	0.0
8:39775625-39775625 G>A	1.0	3466	MELANOMA	-	-	-	-	IDO1	ENST00000519154,p.D68N|ENST00000518237,p.D68N|NM_002164,p.D68N|uc003xnm.3,p.D68N|ENST00000253513,p.D68N|ENST00000522495,p.D68N	retained_intron, protein_coding, nonsense_mediated_decay	uc003xnm.3	nonsynonymous SNV	exon3	c.G202A	p.D68N	RERVEKLNMLSIDHLTDHKSQRLAR	RERVEKLNMLSINHLTDHKSQRLAR	9.0	9.0	-	-	3466_8:39775625-39775625 G>A_RERVEKLNMLSINHLTDHKSQRLAR	0.0
21:22658702-22658702 C>G	0.0	3775	CERVICAL	-	-	-	-	NCAM2	ENST00000400546,p.H151D|uc002yld.2,p.H151D|uc011acc.2,p.H176D|NM_004540,p.H151D|ENST00000535285,p.H176D	protein_coding, processed_transcript	uc011acc.2	nonsynonymous SNV	exon5	c.C526G	p.H176D	SSSPAPAVSWLYHNEEVTTISDNRF	SSSPAPAVSWLYDNEEVTTISDNRF	4.0	6.0	-	-	3775_21:22658702-22658702 C>G_SSSPAPAVSWLYDNEEVTTISDNRF	0.0
X:37893258-37893258 T>C	0.0	4160	COLORECTAL	-	-	-	-	SYTL5	ENST00000357972,p.I39T|NM_138780,p.I39T|uc004ddx.3,p.I39T|NM_001163334,p.I39T|uc004ddu.3,p.I39T|ENST00000456733,p.I39T|NM_001163335,p.I39T|ENST00000297875,p.I39T|uc004ddv.3,p.I39T	protein_coding	uc004ddx.3	nonsynonymous SNV	exon1	c.T116C	p.I39T	RDEYLKKVEDKRIRKLKNELLEAKR	RDEYLKKVEDKRTRKLKNELLEAKR	5.0	2.0	-	-	4160_X:37893258-37893258 T>C_RDEYLKKVEDKRTRKLKNELLEAKR	0.0
11:66191115-66191115 C>A	0.0	4259	COLORECTAL	-	-	-	-	NPAS4	uc001ohx.1,p.A292E|ENST00000311034,p.A292E|uc010rpc.1,p.A82E|NM_178864,p.A292E	retained_intron, protein_coding, nonsense_mediated_decay	uc010rpc.1	nonsynonymous SNV	exon5	c.C245A	p.A82E	MVVRLQAKTGGWAWIYCLLYSEGPE	MVVRLQAKTGGWEWIYCLLYSEGPE	2.0	5.0	-	-	4259_11:66191115-66191115 C>A_MVVRLQAKTGGWEWIYCLLYSEGPE	0.0
9:20764884-20764884 A>G	1.0	3713	MELANOMA	-	-	-	-	FOCAD	NM_017794,p.I171V|ENST00000338382,p.I171V|uc003zog.1,p.I171V|ENST00000380249,p.I171V	protein_coding	uc003zog.1	nonsynonymous SNV	exon9	c.A511G	p.I171V	FQQCPERLEVSCIQIMAPFLWYLYC	FQQCPERLEVSCVQIMAPFLWYLYC	5.0	8.0	-	-	3713_9:20764884-20764884 A>G_FQQCPERLEVSCVQIMAPFLWYLYC	0.0
13:48654103-48654103 G>A	1.0	3784	MELANOMA	-	-	-	-	MED4	uc010tgf.2,p.R127W|NM_014166,p.R173W|ENST00000417167,p.R151W|ENST00000258648,p.R173W|NM_001270629,p.R127W|uc001vby.2,p.R173W|ENST00000378586,p.R127W	protein_coding, processed_transcript	uc010tgf.2	nonsynonymous SNV	exon6	c.C379T	p.R127W	VCAPLTWVPGDPRRPYPTDLEMRSG	VCAPLTWVPGDPWRPYPTDLEMRSG	9.0	9.0	-	-	3784_13:48654103-48654103 G>A_VCAPLTWVPGDPWRPYPTDLEMRSG	0.0
17:7578406-7578406 C>T	1.0	4252	COLORECTAL	-	-	ID=COSM3355994,COSM1640851,COSM99024,COSM99023,COSM10648,COSM99914,COSM99022;OCCURENCE=4(skin),97(breast),9(biliary_tract),321(large_intestine),4(prostate),4(kidney),9(liver),22(pancreas),28(urinary_tract),1(adrenal_gland),65(ovary),1(soft_tissue),9(endometrium),2(salivary_gland),1(penis),18(lung),2(thyroid),35(haematopoietic_and_lymphoid_tissue),4(cervix),62(stomach),70(central_nervous_system),80(oesophagus),2(vulva),3(bone),51(upper_aerodigestive_tract)	1	TP53	NM_001126113,p.R175H|uc010cnf.2,p.R16H|NM_001276699,p.R16H|ENST00000420246,p.R175H|uc002gin.3,p.R82H|NM_001126112,p.R175H|ENST00000359597,p.R175H|NM_001126114,p.R175H|NM_001126116,p.R43H|uc002gig.1,p.R175H|NM_001126118,p.R136H|uc002gij.3,p.R136H|NM_001276760,p.R136H|uc002gih.3,p.R175H|uc002gio.3,p.R43H|uc031qyq.1,p.R136H|uc002gii.2,p.R16H|NM_001276698,p.R16H|NM_001126115,p.R43H|NM_001276761,p.R136H|NM_000546,p.R175H|ENST00000455263,p.R175H|ENST00000269305,p.R175H|uc010cng.2,p.R16H|ENST00000509690,p.R43H|NM_001276696,p.R136H|ENST00000445888,p.R175H|ENST00000413465,p.R175H|ENST00000514944,p.R82H|NM_001126117,p.R43H|uc010vug.3,p.R136H|NM_001276697,p.R16H|NM_001276695,p.R136H	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon4	c.G407A	p.R136H	YKQSQHMTEVVRRCPHHERCSDSDG	YKQSQHMTEVVRHCPHHERCSDSDG	10.0	10.0	-	-	4252_17:7578406-7578406 C>T_YKQSQHMTEVVRHCPHHERCSDSDG	0.0
16:2816138-2816138 C>T	1.0	4189	MELANOMA	-	-	-	-	SRRM2	uc002crk.3,p.P1870L|uc010bsu.1,p.P1774L|uc002crj.1,p.P1774L|uc002crl.1,p.P1870L|ENST00000301740,p.P1870L|NM_016333,p.P1870L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bsu.1	nonsynonymous SNV	exon10	c.C5321T	p.P1774L	PAPWKRSRSRASPATHRRSRSRTPL	PAPWKRSRSRASLATHRRSRSRTPL	10.0	6.0	-	-	4189_16:2816138-2816138 C>T_PAPWKRSRSRASLATHRRSRSRTPL	0.0
1:108291680-108291680 A>C	0.0	4284	COLORECTAL	-	-	-	-	VAV3	uc001dvk.1,p.L471R|ENST00000371846,p.L406R|uc010ouw.1,p.L471R|ENST00000527011,p.L471R|uc001dvl.1,p.L295R|NM_006113,p.L471R|ENST00000370056,p.L471R|uc010oux.1,p.L471R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010oux.1	nonsynonymous SNV	exon15	c.T1412G	p.L471R	DKENKKWSYGFYLIHTQGQNGLEFY	DKENKKWSYGFYRIHTQGQNGLEFY	10.0	3.0	-	-	4284_1:108291680-108291680 A>C_DKENKKWSYGFYRIHTQGQNGLEFY	0.0
7:139299046-139299046 G>A	1.0	4000	MELANOMA	-	-	-	-	HIPK2	NM_022740,p.P659L|NM_001113239,p.P632L|ENST00000342645,p.P659L|ENST00000428878,p.P632L|ENST00000406875,p.P659L|uc003vvd.4,p.P632L|uc003vvf.4,p.P659L	protein_coding	uc003vvf.4	nonsynonymous SNV	exon8	c.C1976T	p.P659L	RPDPFQQALIVCPPGFQGLQASPSK	RPDPFQQALIVCLPGFQGLQASPSK	10.0	5.0	-	-	4000_7:139299046-139299046 G>A_RPDPFQQALIVCLPGFQGLQASPSK	0.0
13:52952490-52952490 C>T	0.0	4189	MELANOMA	-	-	-	-	THSD1	NM_018676,p.E539K|uc001vgo.3,p.E539K|uc001vgp.3,p.E486K|ENST00000258613,p.E539K|NM_199263,p.E486K|ENST00000544466,p.E160K|uc010tgz.2,p.E160K|ENST00000349258,p.E486K	protein_coding	uc010tgz.2	nonsynonymous SNV	exon3	c.G478A	p.E160K	LFSYRLAQQQLKEMKKKGLTETTKV	LFSYRLAQQQLKKMKKKGLTETTKV	4.0	2.0	-	-	4189_13:52952490-52952490 C>T_LFSYRLAQQQLKKMKKKGLTETTKV	0.0
17:47874240-47874240 C>T	0.0	4238	COLORECTAL	-	-	-	2	KAT7	NM_001199155,p.R98C|uc010wmb.2,p.R98C|ENST00000259021,p.R98C|uc002ipl.2,p.R98C|NM_001199157,p.R98C|ENST00000509773,p.R98C|NM_007067,p.R98C|uc002ipm.3,p.R98C|ENST00000424009,p.R98C	retained_intron, protein_coding, processed_transcript	uc010wmb.2	nonsynonymous SNV	exon3	c.C292T	p.R98C	PVTPKKYPLRQTRSSGSETEQVVDF	PVTPKKYPLRQTCSSGSETEQVVDF	6.0	5.0	-	-	4238_17:47874240-47874240 C>T_PVTPKKYPLRQTCSSGSETEQVVDF	0.0
2:206610591-206610591 A>C	0.0	4235	COLORECTAL	-	-	-	-	NRP2	ENST00000412873,p.E588A|uc002vax.3,p.E588A|ENST00000357785,p.E588A|ENST00000357118,p.E588A|ENST00000540178,p.E588A|uc002vaw.3,p.E588A|NM_201267,p.E588A|NM_201279,p.E588A|NM_201266,p.E588A|ENST00000540841,p.E588A|ENST00000360409,p.E588A|uc002vay.3,p.E588A|uc002vav.3,p.E588A|NM_018534,p.E588A|NM_003872,p.E588A|uc002vau.3,p.E588A|ENST00000272849,p.E588A	retained_intron, protein_coding, processed_transcript	uc002vay.3	nonsynonymous SNV	exon10	c.A1763C	p.E588A	ERWSPAGIGMRLEVLGCDWTDSKPT	ERWSPAGIGMRLAVLGCDWTDSKPT	8.0	1.0	-	-	4235_2:206610591-206610591 A>C_ERWSPAGIGMRLAVLGCDWTDSKPT	0.0
3:196842799-196842799 G>A	1.0	3998	MELANOMA	-	-	-	-	DLG1	uc003fxo.4,p.S514L|NM_001098424,p.S514L|uc010ial.3,p.S514L|ENST00000450955,p.S481L|ENST00000346964,p.S514L|uc011bue.2,p.S481L|NM_001290983,p.S514L|ENST00000422288,p.S463L|uc011bub.2,p.S398L|ENST00000419354,p.S514L|NM_001204387,p.S398L|NM_004087,p.S514L|ENST00000357674,p.S481L|ENST00000392381,p.S514L|uc011bud.2,p.S197L|NM_001204386,p.S481L|ENST00000452595,p.S398L|uc010iam.1,p.S481L|ENST00000392382,p.S481L|ENST00000314062,p.S463L|NM_001204388,p.S398L|uc003fxn.4,p.S514L|uc011buc.2,p.S398L|ENST00000443183,p.S398L|ENST00000448528,p.S514L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bue.2	nonsynonymous SNV	exon13	c.C1442T	p.S481L	LSGELRKGDRIISVNSVDLRAASHE	LSGELRKGDRIILVNSVDLRAASHE	10.0	8.0	-	-	3998_3:196842799-196842799 G>A_LSGELRKGDRIILVNSVDLRAASHE	0.0
8:30999034-30999034 C>T	0.0	4155	MELANOMA	-	-	-	1	WRN	ENST00000298139,p.S1019F|uc010lvk.3,p.S486F|uc003xio.4,p.S1019F|NM_000553,p.S1019F	retained_intron, protein_coding	uc010lvk.3	nonsynonymous SNV	exon13	c.C1457T	p.S486F	GKDQTESWWKAFSRQLITEGFLVEV	GKDQTESWWKAFFRQLITEGFLVEV	4.0	1.0	-	-	4155_8:30999034-30999034 C>T_GKDQTESWWKAFFRQLITEGFLVEV	0.0
6:52303267-52303267 C>T	1.0	4129	NSCLC	0.0005	-	ID=COSM191268;OCCURENCE=1(large_intestine)	-	EFHC1	ENST00000433625,p.R60C|NM_001172420,p.R132C|uc003pap.4,p.R151C|ENST00000538167,p.R132C|ENST00000480623,p.R151C|NM_018100,p.R151C|ENST00000371068,p.R151C|uc011dww.2,p.R132C|uc011dwv.1,p.R60C	protein_coding, processed_transcript, nonsense_mediated_decay	uc011dww.2	nonsynonymous SNV	exon4	c.C394T	p.R132C	ENSGILQGKLIKRQRLAKNDRGDHY	ENSGILQGKLIKCQRLAKNDRGDHY	6.0	1.0	-	-	4129_6:52303267-52303267 C>T_ENSGILQGKLIKCQRLAKNDRGDHY	0.0
1:111060224-111060224 C>T	0.0	4346	COLORECTAL	-	-	-	-	KCNA10	ENST00000369771,p.A396T|uc001dzt.1,p.A396T|NM_005549,p.A396T	protein_coding	uc001dzt.1	nonsynonymous SNV	exon1	c.G1186A	p.A396T	IGVILFSSAVYFAEVDEPESHFSSI	IGVILFSSAVYFTEVDEPESHFSSI	1.0	3.0	-	-	4346_1:111060224-111060224 C>T_IGVILFSSAVYFTEVDEPESHFSSI	0.0
13:23912473-23912473 C>A	1.0	4287	COLORECTAL	-	-	-	-	SACS	NM_014363,p.A1848S|ENST00000382298,p.A1848S|ENST00000382292,p.A1848S|uc001uoo.3,p.A1701S|uc001uon.3,p.A1848S|ENST00000402364,p.A1098S|NM_001278055,p.A1701S	protein_coding, processed_transcript	uc001uoo.3	nonsynonymous SNV	exon8	c.G5101T	p.A1701S	ESGRRLGLVPCGAVGVQLSEIQDQK	ESGRRLGLVPCGSVGVQLSEIQDQK	5.0	8.0	-	-	4287_13:23912473-23912473 C>A_ESGRRLGLVPCGSVGVQLSEIQDQK	0.0
8:89054002-89054002 C>T	1.0	3466	MELANOMA	-	-	-	-	MMP16	ENST00000286614,p.G504E|uc003yeb.4,p.G504E|NM_005941,p.G504E	retained_intron, protein_coding, processed_transcript	uc003yeb.4	nonsynonymous SNV	exon10	c.G1511A	p.G504E	VHKENGFTYFYKGKEYWKFNNQILK	VHKENGFTYFYKEKEYWKFNNQILK	8.0	7.0	-	-	3466_8:89054002-89054002 C>T_VHKENGFTYFYKEKEYWKFNNQILK	0.0
8:128750555-128750555 A>G	1.0	4246	COLORECTAL	-	-	-	1	MYC	ENST00000520751,p.T5A	protein_coding	ENST00000520751	nonsynonymous SNV	exon2	c.A13G	p.T5A	MTSTTTRCSRISTATRR	MTSTATRCSRISTATRR	10.0	3.0	-	-	4246_8:128750555-128750555 A>G_MTSTATRCSRISTATRR	0.0
2:3391705-3391705 C>T	1.0	2359	MELANOMA	-	-	-	-	TRAPPC12	ENST00000324266,p.P104L|uc002qxm.1,p.P104L|NM_016030,p.P104L|uc010ewm.1,p.P104L|ENST00000382110,p.P104L|uc002qxn.1,p.P104L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ewm.1	nonsynonymous SNV	exon1	c.C311T	p.P104L	AEPGGEGDPGPEPAGTPSPSGEADG	AEPGGEGDPGPELAGTPSPSGEADG	7.0	9.0	-	-	2359_2:3391705-3391705 C>T_AEPGGEGDPGPELAGTPSPSGEADG	0.0
2:18112823-18112823 C>T	1.0	3466	MELANOMA	-	-	-	-	KCNS3	ENST00000403915,p.S183F|NM_001282428,p.S183F|uc002rcv.3,p.S183F|NM_002252,p.S183F|ENST00000304101,p.S183F|uc021veh.1,p.S183F|uc002rcw.3,p.S183F	protein_coding, processed_transcript	uc021veh.1	nonsynonymous SNV	exon1	c.C548T	p.S183F	IWIRMENPAYCLSAKLIAISSLSVV	IWIRMENPAYCLFAKLIAISSLSVV	10.0	7.0	-	-	3466_2:18112823-18112823 C>T_IWIRMENPAYCLFAKLIAISSLSVV	0.0
4:81122642-81122642 C>A	1.0	4246	COLORECTAL	-	-	-	-	PRDM8	NM_001099403,p.L140I|ENST00000504452,p.L140I|uc010ijo.3,p.L140I|ENST00000339711,p.L140I|ENST00000515013,p.L140I|NM_020226,p.L140I|ENST00000415738,p.L140I|uc003hmb.4,p.L140I|uc003hmc.4,p.L140I	protein_coding, processed_transcript	uc010ijo.3	nonsynonymous SNV	exon7	c.C418A	p.L140I	VWYGKELTELLLLCPSRSHNKMNGS	VWYGKELTELLLICPSRSHNKMNGS	2.0	8.0	-	-	4246_4:81122642-81122642 C>A_VWYGKELTELLLICPSRSHNKMNGS	0.0
16:89702968-89702968 A>C	1.0	4252	COLORECTAL	-	-	-	-	DPEP1	ENST00000261615,p.K133T|uc002fns.4,p.K133T|NM_001128141,p.K133T|NM_004413,p.K133T|ENST00000421184,p.K133T|uc010cin.3,p.K133T|uc002fnr.4,p.K133T|ENST00000393092,p.K133T	retained_intron, protein_coding	uc010cin.3	nonsynonymous SNV	exon5	c.A398C	p.K133T	SSAGIRQAFREGKVASLIGVEGGHS	SSAGIRQAFREGTVASLIGVEGGHS	10.0	5.0	-	-	4252_16:89702968-89702968 A>C_SSAGIRQAFREGTVASLIGVEGGHS	0.0
7:40535981-40535981 C>T	0.0	4281	COLORECTAL	-	-	-	-	SUGCT	NM_001193311,p.P369L|NM_024728,p.P332L|ENST00000309930,p.P369L|uc022acd.1,p.P369L	protein_coding, processed_transcript, nonsense_mediated_decay	uc022acd.1	nonsynonymous SNV	exon12	c.C1106T	p.P369L	GPINNMKNVFAEPQNAVSGFQSLLH	GPINNMKNVFAELQNAVSGFQSLLH	5.0	7.0	-	-	4281_7:40535981-40535981 C>T_GPINNMKNVFAELQNAVSGFQSLLH	0.0
12:129558455-129558455 G>T	0.0	4149	OVARIAN	-	-	-	-	TMEM132D	uc009zyl.1,p.H1089N|ENST00000389441,p.H627N|ENST00000422113,p.H1089N|uc001uia.2,p.H627N|NM_133448,p.H1089N	protein_coding	uc009zyl.1	nonsynonymous SNV	exon9	c.C3265A	p.H1089N	CQDLDPGDCKELHNYMERLHENV	CQDLDPGDCKELNNYMERLHENV	1.0	6.0	-	-	4149_12:129558455-129558455 G>T_CQDLDPGDCKELNNYMERLHENV	0.0
17:2227099-2227099 T>G	1.0	4287	COLORECTAL	-	-	-	-	SRR	uc002fue.1,p.L319V|NM_021947,p.L319V|uc002fui.1,p.L170V|ENST00000344595,p.L319V	protein_coding, processed_transcript	uc002fui.1	nonsynonymous SNV	exon6	c.T508G	p.L170V	NICIVLSGGNVDLTSSITWVKQAER	NICIVLSGGNVDVTSSITWVKQAER	7.0	9.0	-	-	4287_17:2227099-2227099 T>G_NICIVLSGGNVDVTSSITWVKQAER	0.0
X:18923977-18923977 C>A	1.0	4258	ENDOMETRIAL	-	-	-	-	PHKA2	NM_000292,p.G936V|uc004cyv.4,p.G936V|ENST00000379942,p.G936V	protein_coding, processed_transcript	uc004cyv.4	nonsynonymous SNV	exon26	c.G2807T	p.G936V	MATELARSLNCSGEEASESLMNLSP	MATELARSLNCSVEEASESLMNLSP	8.0	10.0	-	-	4258_X:18923977-18923977 C>A_MATELARSLNCSVEEASESLMNLSP	0.0
12:63544475-63544475 C>G	0.0	4258	ENDOMETRIAL	-	-	-	-	AVPR1A	NM_000706,p.E48Q|uc001sro.2,p.E48Q|ENST00000299178,p.E48Q	protein_coding	uc001sro.2	nonsynonymous SNV	exon1	c.G142C	p.E48Q	GEGNGPPRDVRNEELAKLEIAVLAV	GEGNGPPRDVRNQELAKLEIAVLAV	2.0	9.0	-	-	4258_12:63544475-63544475 C>G_GEGNGPPRDVRNQELAKLEIAVLAV	0.0
5:33937381-33937381 C>T	0.0	4158	COLORECTAL	-	-	ID=COSM1437092;OCCURENCE=1(large_intestine)	-	RXFP3	NM_016568,p.T179M|uc003jic.2,p.T179M|ENST00000330120,p.T179M	protein_coding	uc003jic.2	nonsynonymous SNV	exon1	c.C536T	p.T179M	YASVFFLTAMSVTRYHSVASALKSH	YASVFFLTAMSVMRYHSVASALKSH	1.0	5.0	-	-	4158_5:33937381-33937381 C>T_YASVFFLTAMSVMRYHSVASALKSH	0.0
15:34634224-34634224 G>A	1.0	3998	MELANOMA	-	-	-	-	NOP10	uc001zie.1,p.T47I|ENST00000328848,p.T47I|NM_018648,p.T47I	protein_coding	uc001zie.1	nonsynonymous SNV	exon2	c.C140T	p.T47I	FSPDDKYSRHRITIKKRFKVLMTQQ	FSPDDKYSRHRIIIKKRFKVLMTQQ	10.0	7.0	-	-	3998_15:34634224-34634224 G>A_FSPDDKYSRHRIIIKKRFKVLMTQQ	0.0
6:160671658-160671658 T>C	0.0	2591	MELANOMA	-	-	-	-	SLC22A2	ENST00000366952,p.T178A|ENST00000366953,p.T199A|uc003qtf.3,p.T199A|NM_003058,p.T199A|uc003qth.2,p.T199A	protein_coding, processed_transcript	uc003qth.2	nonsynonymous SNV	exon3	c.A595G	p.T199A	NAAAGVLMAISPTYTWMLIFRLIQG	NAAAGVLMAISPAYTWMLIFRLIQG	1.0	9.0	-	-	2591_6:160671658-160671658 T>C_NAAAGVLMAISPAYTWMLIFRLIQG	0.0
8:3474275-3474275 G>A	0.0	4160	COLORECTAL	-	-	-	-	CSMD1	ENST00000520002,p.P352S|ENST00000400186,p.P352S|ENST00000539096,p.P352S|ENST00000602723,p.P352S|uc022aqr.1,p.P352S|NM_033225,p.P352S|ENST00000542608,p.P352S|ENST00000602557,p.P352S|ENST00000537824,p.P352S	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon8	c.C1054T	p.P352S	GGVALVSDMCPDPGIPENGRRAGSD	GGVALVSDMCPDSGIPENGRRAGSD	2.0	9.0	-	-	4160_8:3474275-3474275 G>A_GGVALVSDMCPDSGIPENGRRAGSD	0.0
1:169394098-169394098 A>T	1.0	3879	MELANOMA	-	-	-	-	CCDC181	uc009wvq.1,p.L23Q|uc001gfz.1,p.L23Q|NM_021179,p.L23Q|NM_001300969,p.L23Q|ENST00000456107,p.L23Q|uc001gga.1,p.L23Q|ENST00000367806,p.L23Q|ENST00000367805,p.L23Q|ENST00000545005,p.L23Q|uc001ggc.1,p.L23Q|NM_001300968,p.L23Q|uc001ggb.3,p.L23Q	protein_coding, processed_transcript	uc009wvq.1	nonsynonymous SNV	exon3	c.T68A	p.L23Q	KSEEYEDDFEKDLEWLINENEKSDA	KSEEYEDDFEKDQEWLINENEKSDA	6.0	1.0	-	-	3879_1:169394098-169394098 A>T_KSEEYEDDFEKDQEWLINENEKSDA	0.0
7:100174618-100174618 T>C	1.0	4234	NSCLC	-	-	-	-	LRCH4	ENST00000310300,p.K459E|NM_001289934,p.K459E|NM_002319,p.K459E|uc003uvj.3,p.K459E	retained_intron, protein_coding	uc003uvj.3	nonsynonymous SNV	exon13	c.A1375G	p.K459E	AVSTQAMHNGSPKSSASQAGAAAGQ	AVSTQAMHNGSPESSASQAGAAAGQ	9.0	4.0	-	-	4234_7:100174618-100174618 T>C_AVSTQAMHNGSPESSASQAGAAAGQ	0.0
6:146056349-146056349 C>T	0.0	3775	CERVICAL	-	-	-	-	EPM2A	uc010khr.3,p.E96K|ENST00000367519,p.E96K|NM_001018041,p.E96K|NM_005670,p.E96K|uc003qkv.3,p.E96K|uc003qkw.3,p.E96K	protein_coding, processed_transcript	uc010khr.3	nonsynonymous SNV	exon1	c.G286A	p.E96K	FWYKFLKREPGGELSWEGNGPHHDR	FWYKFLKREPGGKLSWEGNGPHHDR	4.0	6.0	-	-	3775_6:146056349-146056349 C>T_FWYKFLKREPGGKLSWEGNGPHHDR	0.0
12:50357341-50357341 C>A	0.0	4287	COLORECTAL	-	-	-	-	AQP5	ENST00000293599,p.L144I|uc001rvo.3,p.L144I|NM_001651,p.L144I	retained_intron, protein_coding	uc001rvo.3	nonsynonymous SNV	exon2	c.C430A	p.L144I	MVVELILTFQLALCIFASTDSRRTS	MVVELILTFQLAICIFASTDSRRTS	3.0	8.0	-	-	4287_12:50357341-50357341 C>A_MVVELILTFQLAICIFASTDSRRTS	0.0
4:151504807-151504807 A>C	0.0	3903	MELANOMA	-	-	-	-	MAB21L2	ENST00000317605,p.N209T|uc003ilw.3,p.N209T|NM_006439,p.N209T	protein_coding	uc003ilw.3	nonsynonymous SNV	exon1	c.A626C	p.N209T	PNRVAEVKAEGFNLLSKECYSLTGK	PNRVAEVKAEGFTLLSKECYSLTGK	2.0	1.0	-	-	3903_4:151504807-151504807 A>C_PNRVAEVKAEGFTLLSKECYSLTGK	0.0
14:73577758-73577758 C>T	1.0	3713	MELANOMA	-	-	-	-	RBM25	NM_021239,p.P638S|uc001xno.3,p.P638S|ENST00000261973,p.P638S|uc010ttu.2,p.P638S|ENST00000527432,p.P638S|uc001xnp.3,p.P433S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ttu.2	nonsynonymous SNV	exon16	c.C1912T	p.P638S	VSSASGNATPNTPGDESPCGIIIPH	VSSASGNATPNTSGDESPCGIIIPH	10.0	2.0	-	-	3713_14:73577758-73577758 C>T_VSSASGNATPNTSGDESPCGIIIPH	0.0
1:223285703-223285703 C>T	0.0	4158	COLORECTAL	-	-	-	-	TLR5	uc001hnv.2,p.R224K|ENST00000540964,p.R224K|ENST00000342210,p.R224K|uc001hnw.2,p.R224K|uc021pjl.1,p.R224K|NM_003268,p.R224K|ENST00000366881,p.R224K	protein_coding, processed_transcript	uc021pjl.1	nonsynonymous SNV	exon1	c.G671A	p.R224K	VSVDWGKCMNPFRNMVLEILDVSGN	VSVDWGKCMNPFKNMVLEILDVSGN	5.0	10.0	-	-	4158_1:223285703-223285703 C>T_VSVDWGKCMNPFKNMVLEILDVSGN	0.0
12:112326792-112326792 C>T	1.0	3879	MELANOMA	-	-	-	-	MAPKAPK5	NM_003668,p.L402F|ENST00000550735,p.L402F|uc001tsz.4,p.L402F	retained_intron, protein_coding, processed_transcript	uc001tsz.4	nonsynonymous SNV	exon12	c.C1204T	p.L402F	LEKLRDVIAQCILPQAGENEDEKLN	LEKLRDVIAQCIFPQAGENEDEKLN	9.0	9.0	-	-	3879_12:112326792-112326792 C>T_LEKLRDVIAQCIFPQAGENEDEKLN	0.0
1:228505294-228505294 G>A	0.0	4301	MELANOMA	-	-	-	-	OBSCN	ENST00000366707,p.G2198E|uc001hsn.4,p.G4564E|uc001hsq.2,p.G5521E|uc009xez.2,p.G4564E|ENST00000570156,p.G5521E|ENST00000366709,p.G1683E|ENST00000284548,p.G4564E|NM_001271223,p.G5521E|NM_052843,p.G4564E|NM_001098623,p.G4564E|ENST00000422127,p.G4564E	retained_intron, protein_coding, processed_transcript	uc009xez.2	nonsynonymous SNV	exon52	c.G13691A	p.G4564E	GGLCGYRVEVKEGATGQWRLCHELV	GGLCGYRVEVKEEATGQWRLCHELV	7.0	10.0	-	-	4301_1:228505294-228505294 G>A_GGLCGYRVEVKEEATGQWRLCHELV	0.0
11:67186691-67186691 G>A	1.0	4266	COLORECTAL	-	-	-	-	CARNS1	ENST00000423745,p.E154K|uc010rpr.2,p.E277K|ENST00000531040,p.E277K|ENST00000445895,p.E277K|uc009yrp.3,p.E154K|NM_020811,p.E154K|NM_001166222,p.E277K|ENST00000307823,p.E154K|uc001olc.4,p.E293K	retained_intron, protein_coding, processed_transcript	uc010rpr.2	nonsynonymous SNV	exon5	c.G829A	p.E277K	LVKEEVEAFLRSEALGDILQVAVKL	LVKEEVEAFLRSKALGDILQVAVKL	3.0	9.0	-	-	4266_11:67186691-67186691 G>A_LVKEEVEAFLRSKALGDILQVAVKL	0.0
7:120935629-120935629 C>T	0.0	3713	MELANOMA	-	-	ID=COSM1548033;OCCURENCE=1(lung)	-	CPED1	NM_024913,p.H1002Y|uc003vjq.4,p.H1002Y|ENST00000310396,p.H1002Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc003vjq.4	nonsynonymous SNV	exon23	c.C3004T	p.H1002Y	QQGTVTNFRSPYHVRGPINQVCSEI	QQGTVTNFRSPYYVRGPINQVCSEI	3.0	1.0	-	-	3713_7:120935629-120935629 C>T_QQGTVTNFRSPYYVRGPINQVCSEI	0.0
16:67412546-67412546 G>A	1.0	3903	MELANOMA	-	-	-	-	LRRC36	NM_001161575,p.E500K|ENST00000329956,p.E621K|ENST00000563189,p.E500K|NM_018296,p.E621K|uc002esx.3,p.E500K|ENST00000541146,p.E93K|uc002esv.3,p.E621K|uc010vjk.2,p.E396K|ENST00000435835,p.E396K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vjk.2	nonsynonymous SNV	exon7	c.G1186A	p.E396K	LVRVLEENLILSEKIQQLEEGAAIS	LVRVLEENLILSKKIQQLEEGAAIS	2.0	7.0	-	-	3903_16:67412546-67412546 G>A_LVRVLEENLILSKKIQQLEEGAAIS	0.0
3:3076343-3076343 C>A	1.0	3795	MELANOMA	-	-	-	-	CNTN4	uc003bpe.3,p.T276K|ENST00000358480,p.T385K|ENST00000397459,p.T276K|ENST00000448906,p.T276K|NM_175607,p.T604K|uc021wsg.1,p.T604K|ENST00000418658,p.T604K|ENST00000397461,p.T604K|ENST00000427331,p.T604K|NM_175613,p.T276K|uc003bpc.3,p.T604K|NM_001206956,p.T275K|uc003bpd.1,p.T604K|uc003bpf.3,p.T275K|NM_001206955,p.T604K|uc003bpb.1,p.T275K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wsg.1	nonsynonymous SNV	exon16	c.C1811A	p.T604K	IVRGPPGPPEAVTIDEITDTTAQLS	IVRGPPGPPEAVKIDEITDTTAQLS	10.0	8.0	-	-	3795_3:3076343-3076343 C>A_IVRGPPGPPEAVKIDEITDTTAQLS	0.0
11:5878401-5878401 G>A	0.0	4158	COLORECTAL	-	-	-	-	OR52E8	NM_001005168,p.R178C|ENST00000537935,p.R178C|uc010qzr.2,p.R178C	protein_coding	uc010qzr.2	nonsynonymous SNV	exon1	c.C532T	p.R178C	VFLLLRLPFCGHRIIPHTYCEHMGI	VFLLLRLPFCGHCIIPHTYCEHMGI	1.0	6.0	-	-	4158_11:5878401-5878401 G>A_VFLLLRLPFCGHCIIPHTYCEHMGI	0.0
12:8925971-8925971 A>G	0.0	4346	COLORECTAL	-	-	-	-	RIMKLB	NM_020734,p.Q251R|NM_001297776,p.Q251R|ENST00000538135,p.Q251R|ENST00000357529,p.Q251R|uc001qux.2,p.Q251R|uc001quw.2,p.Q251R|ENST00000544257,p.Q251R|uc010sgl.1,p.Q251R|ENST00000535829,p.Q251R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sgl.1	nonsynonymous SNV	exon6	c.A752G	p.Q251R	CSLSEQGKQLAIQVSNILGMDVCGI	CSLSEQGKQLAIRVSNILGMDVCGI	6.0	8.0	-	-	4346_12:8925971-8925971 A>G_CSLSEQGKQLAIRVSNILGMDVCGI	0.0
2:79350281-79350281 G>C	1.0	4234	NSCLC	-	-	-	-	REG1A	ENST00000233735,p.Q147H|uc010ysd.2,p.Q147H|uc002snz.3,p.Q147H|NM_002909,p.Q147H	retained_intron, protein_coding	uc010ysd.2	nonsynonymous SNV	exon5	c.G441C	p.Q147H	GYCVSLTSSTGFQKWKDVPCEDKFS	GYCVSLTSSTGFHKWKDVPCEDKFS	7.0	7.0	-	-	4234_2:79350281-79350281 G>C_GYCVSLTSSTGFHKWKDVPCEDKFS	0.0
4:101953517-101953517 C>T	1.0	4000	MELANOMA	-	-	-	-	PPP3CA	NM_001130692,p.E374K|uc011cen.1,p.E416K|NM_000944,p.E416K|ENST00000507176,p.E318K|uc010ilk.2,p.E184K|ENST00000394853,p.E416K|ENST00000394854,p.E416K|uc003hvt.2,p.E403K|ENST00000512215,p.E184K|ENST00000523694,p.E349K|ENST00000323055,p.E374K|uc003hvu.2,p.E416K|NM_001130691,p.E416K|uc003hvs.2,p.E349K|uc010ilj.2,p.E374K	protein_coding, processed_transcript, nonsense_mediated_decay	uc011cen.1	nonsynonymous SNV	exon12	c.G1246A	p.E416K	GKMARVFSVLREESESVLTLKGLTP	GKMARVFSVLREKSESVLTLKGLTP	9.0	4.0	-	-	4000_4:101953517-101953517 C>T_GKMARVFSVLREKSESVLTLKGLTP	0.0
7:100638484-100638484 A>T	0.0	4237	NSCLC	-	rs199794194	-	-	MUC12	NM_001164462,p.K1547I|uc003uxo.3,p.K1547I|ENST00000379442,p.K1690I|ENST00000536621,p.K1547I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uxo.3	nonsynonymous SNV	exon2	c.A4640T	p.K1547I	LPGSTTTAGLSEKSTTFYSSPRSPD	LPGSTTTAGLSEISTTFYSSPRSPD	5.0	10.0	-	-	4237_7:100638484-100638484 A>T_LPGSTTTAGLSEISTTFYSSPRSPD	0.0
19:40883777-40883777 C>T	1.0	4320	COLORECTAL	-	-	ID=COSM1681034,COSM1681035;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	PLD3	uc002onm.4,p.R424C|ENST00000409587,p.R424C|NM_012268,p.R424C|ENST00000409281,p.R424C|ENST00000409735,p.R424C|ENST00000356508,p.R424C|NM_001291311,p.R424C|uc002onj.4,p.R424C|uc002onn.3,p.R424C|NM_001031696,p.R424C|ENST00000409419,p.R424C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002onn.3	nonsynonymous SNV	exon12	c.C1270T	p.R424C	ARVNHNKYMVTERATYIGTSNWSGN	ARVNHNKYMVTECATYIGTSNWSGN	10.0	9.0	-	-	4320_19:40883777-40883777 C>T_ARVNHNKYMVTECATYIGTSNWSGN	0.0
9:98209671-98209671 G>C	0.0	4278	COLORECTAL	-	-	-	1	PTCH1	NM_000264,p.D1289E|uc010mrq.3,p.D1138E|uc004avl.4,p.D1138E|ENST00000430669,p.D1223E|NM_001083604,p.D1138E|ENST00000437951,p.D1223E|ENST00000375274,p.D1288E|NM_001083602,p.D1223E|uc010mrn.3,p.D81E|ENST00000421141,p.D1138E|uc004avm.4,p.D1288E|NM_001083603,p.D1288E|NM_001083605,p.D1138E|uc010mrp.3,p.D1138E|NM_001083607,p.D1138E|ENST00000418258,p.D1138E|uc010mro.3,p.D1138E|ENST00000429896,p.D1138E|uc010mrr.3,p.D1223E|NM_001083606,p.D1138E|uc004avk.4,p.D1289E|ENST00000331920,p.D1289E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010mrr.3	nonsynonymous SNV	exon23	c.C3669G	p.D1223E	HPPSNPRQQPHLDSGSLPPGRQGQQ	HPPSNPRQQPHLESGSLPPGRQGQQ	9.0	5.0	-	-	4278_9:98209671-98209671 G>C_HPPSNPRQQPHLESGSLPPGRQGQQ	0.0
22:31884694-31884696 CTC>-	1.0	4160	COLORECTAL	-	-	-	-	EIF4ENIF1	ENST00000397523,p.3_4del|uc003alc.1,p.3_4del|NM_001164501,p.3_4del|ENST00000330125,p.3_4del|uc003alb.2,p.3_4del|NM_001164502,p.3_4del|ENST00000397525,p.3_4del|ENST00000344710,p.3_4del|NM_019843,p.3_4del|uc003ala.2,p.3_4del|uc003akz.2,p.3_4del	retained_intron, protein_coding, nonsense_mediated_decay	uc003alc.1	nonframeshift deletion	exon2	c.9_11del	p.3_4del	MDRRSMGETESGDAF	MDRSMGETESGDAFL	8.0	9.0	-	-	4160_22:31884694-31884696 CTC>-_MDRSMGETESGDAFL	0.0
1:176709319-176709319 C>T	0.0	2591	MELANOMA	-	-	-	-	PAPPA2	NM_020318,p.H1380Y|uc001gkz.3,p.H1380Y|ENST00000367662,p.H1380Y	protein_coding, processed_transcript	uc001gkz.3	nonsynonymous SNV	exon14	c.C4138T	p.H1380Y	PSNCISEDEGQNHQGQSCIHRPCGK	PSNCISEDEGQNYQGQSCIHRPCGK	1.0	4.0	-	-	2591_1:176709319-176709319 C>T_PSNCISEDEGQNYQGQSCIHRPCGK	0.0
6:56336886-56336886 G>T	1.0	4266	COLORECTAL	-	-	-	-	DST	ENST00000370788,p.L4971I|uc021zaz.2,p.L5080I|uc003pcy.4,p.L4754I|uc021zay.2,p.L5120I|ENST00000446842,p.L6842I|ENST00000370754,p.L7346I|NM_183380,p.L5080I|NM_001144770,p.L5120I|NM_015548,p.L4754I|ENST00000361203,p.L7057I|ENST00000370769,p.L7168I|NM_001144769,p.L5258I|uc021zba.2,p.L5258I|ENST00000244364,p.L4754I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zba.2	nonsynonymous SNV	exon88	c.C15772A	p.L5258I	QVWLLALERRRKLNDALDRLEELRE	QVWLLALERRRKINDALDRLEELRE	8.0	8.0	-	-	4266_6:56336886-56336886 G>T_QVWLLALERRRKINDALDRLEELRE	0.0
12:11061864-11061864 C>T	0.0	4160	COLORECTAL	-	-	-	-	TAS2R13	NM_023920,p.V12I|uc001qzg.1,p.V12I|ENST00000390677,p.V12I	protein_coding	uc001qzg.1	nonsynonymous SNV	exon1	c.G34A	p.V12I	MESALPSIFTLVIIAEFIIGNLSN	MESALPSIFTLIIIAEFIIGNLSN	1.0	5.0	-	-	4160_12:11061864-11061864 C>T_MESALPSIFTLIIIAEFIIGNLSN	0.0
2:11427807-11427807 T>A	1.0	4278	COLORECTAL	-	-	-	-	ROCK2	ENST00000315872,p.K66M|NM_004850,p.K66M|uc002rbd.1,p.K66M|ENST00000261535,p.K66M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rbd.1	nonsynonymous SNV	exon2	c.A197T	p.K66M	VLDLDFPALRKNKNIDNFLNRYEKI	VLDLDFPALRKNMNIDNFLNRYEKI	9.0	8.0	-	-	4278_2:11427807-11427807 T>A_VLDLDFPALRKNMNIDNFLNRYEKI	0.0
5:175782629-175782629 C>T	1.0	4180	BREAST	-	-	-	-	KIAA1191	NM_001079685,p.G51D|uc003mdx.3,p.G32D|NM_020444,p.G51D|NM_001287336,p.G32D|ENST00000506983,p.G32D|ENST00000504688,p.G32D|uc003mdy.3,p.G51D|ENST00000298569,p.G51D|ENST00000510164,p.G51D|ENST00000503082,p.G32D|uc003mdw.3,p.G51D|ENST00000393725,p.G32D|NM_001079684,p.G32D	retained_intron, protein_coding, processed_transcript	uc003mdy.3	nonsynonymous SNV	exon3	c.G152A	p.G51D	DPAPMTPPPSDMGSVPWKPVIPERK	DPAPMTPPPSDMDSVPWKPVIPERK	10.0	6.0	-	-	4180_5:175782629-175782629 C>T_DPAPMTPPPSDMDSVPWKPVIPERK	0.0
2:113943552-113943552 G>A	0.0	2591	MELANOMA	-	-	-	-	PSD4	uc002tjc.3,p.E450K|uc002tjf.3,p.E71K|NM_012455,p.E450K|uc002tjd.3,p.E71K|ENST00000245796,p.E450K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tjf.3	nonsynonymous SNV	exon3	c.G211A	p.E71K	RSPASSPEPSSPESESRGPGPRPSP	RSPASSPEPSSPKSESRGPGPRPSP	3.0	2.0	-	-	2591_2:113943552-113943552 G>A_RSPASSPEPSSPKSESRGPGPRPSP	0.0
1:243736232-243736232 A>C	0.0	4345	COLORECTAL	-	-	-	2	AKT3	uc001hzz.1,p.L272R|uc021plu.1,p.L272R|NM_001206729,p.L272R|ENST00000336199,p.L272R|ENST00000263826,p.L272R|NM_005465,p.L272R|ENST00000366539,p.L272R|uc001iab.2,p.L272R|NM_181690,p.L272R|ENST00000366540,p.L272R	protein_coding, processed_transcript	uc021plu.1	nonsynonymous SNV	exon9	c.T815G	p.L272R	DYLHSGKIVYRDLKLENLMLDKDGH	DYLHSGKIVYRDRKLENLMLDKDGH	5.0	6.0	-	-	4345_1:243736232-243736232 A>C_DYLHSGKIVYRDRKLENLMLDKDGH	0.0
9:32631370-32631370 G>A	0.0	4160	COLORECTAL	-	-	ID=COSM1108221;OCCURENCE=1(endometrium)	-	TAF1L	ENST00000242310,p.T1403M|NM_153809,p.T1403M|uc003zrg.1,p.T1403M	protein_coding	uc003zrg.1	nonsynonymous SNV	exon1	c.C4208T	p.T1403M	KSIHRRRTDPMVTLSSILESIINDM	KSIHRRRTDPMVMLSSILESIINDM	2.0	6.0	-	-	4160_9:32631370-32631370 G>A_KSIHRRRTDPMVMLSSILESIINDM	0.0
11:33886211-33886211 C>T	0.0	4155	MELANOMA	-	-	-	1	LMO2	uc001mvc.3,p.G58D|ENST00000395833,p.G65D|NM_005574,p.G134D|uc001mve.3,p.G65D|NM_001142316,p.G65D|ENST00000257818,p.G134D|NM_001142315,p.G65D|uc010rel.2,p.G65D|uc010rem.2,p.G134D|uc001mvd.3,p.G58D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rem.2	nonsynonymous SNV	exon5	c.G401A	p.G134D	DCLSCDLCGCRLGEVGRRLYYKLGR	DCLSCDLCGCRLDEVGRRLYYKLGR	3.0	7.0	-	-	4155_11:33886211-33886211 C>T_DCLSCDLCGCRLDEVGRRLYYKLGR	0.0
10:101089928-101089928 T>A	0.0	4259	COLORECTAL	-	-	-	-	CNNM1	ENST00000446890,p.S191T|uc010qpi.2,p.S262T|uc009xwf.3,p.S262T|NM_020348,p.S262T|ENST00000370528,p.S191T|ENST00000356713,p.S262T|uc001kpp.4,p.S262T|uc009xwe.3,p.S262T	protein_coding, processed_transcript	uc010qpi.2	nonsynonymous SNV	exon1	c.T784A	p.S262T	DPVELRVLRNSGSAAEQEQARRVQA	DPVELRVLRNSGTAAEQEQARRVQA	2.0	4.0	-	-	4259_10:101089928-101089928 T>A_DPVELRVLRNSGTAAEQEQARRVQA	0.0
1:215408442-215408442 C>T	0.0	4213	COLORECTAL	-	-	ID=COSM3934466,COSM3934465;OCCURENCE=1(oesophagus)	-	KCNK2	NM_001017425,p.P412L|uc001hkr.4,p.P397L|uc001hkq.3,p.P412L|NM_014217,p.P397L|ENST00000444842,p.P412L|NM_001017424,p.P408L|ENST00000391895,p.P408L|uc001hko.3,p.P408L|ENST00000391894,p.P397L	protein_coding, nonsense_mediated_decay	uc001hkr.4	nonsynonymous SNV	exon7	c.C1190T	p.P397L	LKTESIYLNGLTPHCAGEEIAVIEN	LKTESIYLNGLTLHCAGEEIAVIEN	3.0	7.0	-	-	4213_1:215408442-215408442 C>T_LKTESIYLNGLTLHCAGEEIAVIEN	0.0
3:184025754-184025754 C>T	1.0	3466	MELANOMA	-	-	-	-	PSMD2	uc011brj.1,p.A633V|NM_001278708,p.A662V|uc011brk.1,p.A662V|ENST00000310118,p.A792V|NM_001278709,p.A633V|ENST00000439383,p.A662V|ENST00000435761,p.A633V|uc003fnn.1,p.A792V|NM_002808,p.A792V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011brk.1	nonsynonymous SNV	exon17	c.C1985T	p.A662V	PYHSDRQLMSQVAVAGLLTVLVSFL	PYHSDRQLMSQVVVAGLLTVLVSFL	10.0	5.0	-	-	3466_3:184025754-184025754 C>T_PYHSDRQLMSQVVVAGLLTVLVSFL	0.0
13:32722023-32722023 G>T	0.0	4335	COLORECTAL	-	-	-	-	FRY	ENST00000380250,p.G444V|uc001utx.3,p.G444V|NM_023037,p.G444V	protein_coding, processed_transcript, nonsense_mediated_decay	uc001utx.3	nonsynonymous SNV	exon13	c.G1331T	p.G444V	TIITTLFPKGSRGVVPRDMPLNIFV	TIITTLFPKGSRVVVPRDMPLNIFV	7.0	9.0	-	-	4335_13:32722023-32722023 G>T_TIITTLFPKGSRVVVPRDMPLNIFV	0.0
19:35836518-35836518 C>T	1.0	4189	MELANOMA	-	-	-	-	CD22	ENST00000419549,p.P569L|NM_001771,p.P741L|NM_001185101,p.P564L|ENST00000536635,p.P653L|ENST00000341773,p.P564L|uc002nzb.4,p.P564L|uc010xst.2,p.P569L|uc010edt.3,p.P741L|NM_001185099,p.P653L|uc010edu.3,p.P653L|ENST00000594250,p.P564L|NM_001278417,p.P569L|ENST00000085219,p.P741L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xst.2	nonsynonymous SNV	exon12	c.C1706T	p.P569L	SFFVRNKKVRRAPLSEGPHSLGCYN	SFFVRNKKVRRALLSEGPHSLGCYN	7.0	6.0	-	-	4189_19:35836518-35836518 C>T_SFFVRNKKVRRALLSEGPHSLGCYN	0.0
X:123554578-123554578 T>A	0.0	4301	MELANOMA	-	-	-	-	TENM1	uc010nqy.3,p.N1522I|ENST00000422452,p.N1522I|NM_014253,p.N1515I|uc004euj.3,p.N1515I|ENST00000371130,p.N1515I|NM_001163279,p.N1521I|NM_001163278,p.N1522I|uc011muj.2,p.N1521I	protein_coding, processed_transcript	uc011muj.2	nonsynonymous SNV	exon25	c.A4562T	p.N1521I	SPDGTLYVADLGNVRIRTISRNQAH	SPDGTLYVADLGIVRIRTISRNQAH	4.0	9.0	-	-	4301_X:123554578-123554578 T>A_SPDGTLYVADLGIVRIRTISRNQAH	0.0
X:44942752-44942752 G>C	1.0	3775	CERVICAL	-	-	-	1	KDM6A	uc011mla.2,p.R1066P|uc011mkz.2,p.R1163P|NM_001291417,p.R1066P|ENST00000536777,p.R1066P|uc004dge.4,p.R1111P|NM_001291416,p.R1118P|uc011mlc.2,p.R815P|NM_001291421,p.R815P|uc022bvj.1,p.R1032P|ENST00000377967,p.R1111P|NM_021140,p.R1111P|ENST00000543216,p.R1032P|uc011mlb.2,p.R1118P|NM_001291415,p.R1163P|NM_001291418,p.R1032P|ENST00000382899,p.R1118P|uc011mld.2,p.R750P	protein_coding, processed_transcript	uc022bvj.1	nonsynonymous SNV	exon21	c.G3095C	p.R1032P	QLHELTKLPAFVRVVSAGNLLSHVG	QLHELTKLPAFVPVVSAGNLLSHVG	9.0	6.0	-	-	3775_X:44942752-44942752 G>C_QLHELTKLPAFVPVVSAGNLLSHVG	0.0
12:11420941-11420941 G>C	1.0	4317	COLORECTAL	-	-	ID=COSM1242709,COSM1242708;OCCURENCE=1(oesophagus)	-	PRB3	NM_006249,p.P81R|ENST00000381842,p.P81R|uc001qzs.3,p.P81R|ENST00000538488,p.P81R	retained_intron, protein_coding, processed_transcript, polymorphic_pseudogene	uc001qzs.3	nonsynonymous SNV	exon3	c.C242G	p.P81R	QGPPPRPGKPEGPPPQGGNQSQGPP	QGPPPRPGKPEGRPPQGGNQSQGPP	2.0	3.0	-	-	4317_12:11420941-11420941 G>C_QGPPPRPGKPEGRPPQGGNQSQGPP	0.0
1:44450603-44450603 G>A	1.0	4180	BREAST	-	-	-	-	B4GALT2	NM_001005417,p.D206N|ENST00000372324,p.D206N|NM_003780,p.D206N|NM_030587,p.D235N|uc001clh.3,p.D140N|ENST00000309519,p.D235N|ENST00000434555,p.D140N|uc001clg.3,p.D206N|uc010okl.2,p.D235N|uc001cli.3,p.D206N|ENST00000356836,p.D206N	protein_coding, processed_transcript	uc010okl.2	nonsynonymous SNV	exon4	c.G703A	p.D235N	LLNVGFLEALKEDAAYDCFIFSDVD	LLNVGFLEALKENAAYDCFIFSDVD	10.0	10.0	-	-	4180_1:44450603-44450603 G>A_LLNVGFLEALKENAAYDCFIFSDVD	0.0
14:105412858-105412858 T>G	1.0	4345	COLORECTAL	-	-	-	-	AHNAK2	ENST00000333244,p.K2977T|uc001ypx.2,p.K2877T|NM_138420,p.K2977T|uc010axc.1,p.K2977T	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.A8930C	p.K2977T	SLADKDVTAKDSKFKMPKFKMPSFG	SLADKDVTAKDSTFKMPKFKMPSFG	10.0	2.0	-	-	4345_14:105412858-105412858 T>G_SLADKDVTAKDSTFKMPKFKMPSFG	0.0
1:152285630-152285630 C>T	0.0	2556	MELANOMA	-	-	-	-	FLG	ENST00000368799,p.G578R|NM_002016,p.G578R|uc001ezu.1,p.G578R	protein_coding	uc001ezu.1	nonsynonymous SNV	exon3	c.G1732A	p.G578R	SASRQTRNEEQSGDGTRHSGSRHHE	SASRQTRNEEQSRDGTRHSGSRHHE	1.0	5.0	-	-	2556_1:152285630-152285630 C>T_SASRQTRNEEQSRDGTRHSGSRHHE	0.0
7:23830536-23830536 T>G	1.0	4252	COLORECTAL	-	-	-	-	STK31	NM_032944,p.L888V|uc003swv.1,p.L77V|uc010kuq.4,p.L888V|uc003sws.5,p.L911V|ENST00000354639,p.L888V|NM_031414,p.L911V|NM_001260504,p.L888V|uc003swt.5,p.L888V|uc031swr.1,p.L888V|ENST00000355870,p.L911V|ENST00000428484,p.L888V	retained_intron, protein_coding, processed_transcript	uc031swr.1	nonsynonymous SNV	exon22	c.T2662G	p.L888V	LKMGKPASPGSDLYAYGCLLLWLSV	LKMGKPASPGSDVYAYGCLLLWLSV	6.0	2.0	-	-	4252_7:23830536-23830536 T>G_LKMGKPASPGSDVYAYGCLLLWLSV	0.0
3:193080230-193080230 G>A	0.0	2591	MELANOMA	-	-	-	-	ATP13A5	uc011bsq.2,p.S159F|ENST00000342358,p.S159F|NM_198505,p.S159F	retained_intron, protein_coding, processed_transcript	uc011bsq.2	nonsynonymous SNV	exon5	c.C476T	p.S159F	RFQKVGLLEDSNSCSDIHQTFGLGL	RFQKVGLLEDSNFCSDIHQTFGLGL	1.0	5.0	-	-	2591_3:193080230-193080230 G>A_RFQKVGLLEDSNFCSDIHQTFGLGL	0.0
10:86131262-86131262 T>C	1.0	3713	MELANOMA	-	-	-	-	CCSER2	uc001kdh.1,p.F152L|NM_001284240,p.F152L|NM_018999,p.F152L|uc010qmd.1,p.F152L|ENST00000372088,p.F152L|ENST00000359979,p.F152L|ENST00000224756,p.F152L|uc001kdg.1,p.F152L|NM_001284241,p.F152L	protein_coding, processed_transcript	uc010qmd.1	nonsynonymous SNV	exon2	c.T454C	p.F152L	QKSFSGPSNLGKFTKGTLLGRTSYS	QKSFSGPSNLGKLTKGTLLGRTSYS	7.0	6.0	-	-	3713_10:86131262-86131262 T>C_QKSFSGPSNLGKLTKGTLLGRTSYS	0.0
8:22470624-22470624 C>T	1.0	3903	MELANOMA	-	-	-	-	CCAR2	uc003xch.3,p.H227Y|ENST00000308511,p.H227Y|uc003xci.3,p.H227Y|ENST00000522599,p.H45Y|ENST00000389279,p.H227Y|NM_021174,p.H227Y	retained_intron, protein_coding	uc003xci.3	nonsynonymous SNV	exon8	c.C679T	p.H227Y	KKPRHDLPPYRVHLTPYTVDSPICD	KKPRHDLPPYRVYLTPYTVDSPICD	10.0	6.0	CD8	-	3903_8:22470624-22470624 C>T_KKPRHDLPPYRVYLTPYTVDSPICD	1.0
19:12985670-12985670 C>T	0.0	4284	COLORECTAL	-	-	-	-	MAST1	uc002mvm.3,p.P1567S|NM_014975,p.P1567S|ENST00000251472,p.P1567S	retained_intron, protein_coding	uc002mvm.3	nonsynonymous SNV	exon26	c.C4699T	p.P1567S	AGLTKKGVSSPAPPGP	AGLTKKGVSSPASPGP	5.0	9.0	-	-	4284_19:12985670-12985670 C>T_AGLTKKGVSSPASPGP	0.0
1:171544232-171544232 C>T	1.0	3466	MELANOMA	-	-	-	-	PRRC2C	NM_015172,p.P2305L|ENST00000392078,p.P2307L|uc010pmi.2,p.P142L|uc010pmg.2,p.P2305L|ENST00000338920,p.P2305L|ENST00000367742,p.P2307L|ENST00000426496,p.P2240L|uc010pmh.2,p.P1217L	retained_intron, protein_coding, processed_transcript	uc010pmi.2	nonsynonymous SNV	exon7	c.C425T	p.P142L	YNSFSSASMPQIPVASVTPTASLSG	YNSFSSASMPQILVASVTPTASLSG	10.0	3.0	-	-	3466_1:171544232-171544232 C>T_YNSFSSASMPQILVASVTPTASLSG	0.0
5:118860945-118860945 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1696075;OCCURENCE=1(skin)	-	HSD17B4	ENST00000510025,p.P489L|ENST00000414835,p.P373L|NM_001292027,p.P489L|ENST00000256216,p.P513L|uc011cwg.2,p.P489L|uc010jcn.2,p.P251L|NM_001292028,p.P373L|uc003ksk.4,p.P366L|uc011cwh.2,p.P495L|uc011cwj.2,p.P366L|ENST00000513628,p.P376L|NM_001199291,p.P538L|ENST00000509514,p.P251L|ENST00000504811,p.P538L|NM_000414,p.P513L|ENST00000515320,p.P495L|NM_001199292,p.P495L|uc003ksj.3,p.P513L|uc011cwi.2,p.P538L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cwj.2	nonsynonymous SNV	exon13	c.C1097T	p.P366L	QAALYRLSGDWNPLHIDPNFASLAG	QAALYRLSGDWNLLHIDPNFASLAG	10.0	6.0	-	-	3713_5:118860945-118860945 C>T_QAALYRLSGDWNLLHIDPNFASLAG	0.0
5:5242274-5242274 C>T	0.0	4275	COLORECTAL	-	-	-	-	ADAMTS16	NM_139056,p.R878C|uc003jdk.1,p.R878C|ENST00000274181,p.R878C|uc003jdl.3,p.R878C	retained_intron, protein_coding, processed_transcript	uc003jdl.3	nonsynonymous SNV	exon17	c.C2632T	p.R878C	PPAQPSYTWAIVRSECSVSCGGGQM	PPAQPSYTWAIVCSECSVSCGGGQM	3.0	7.0	-	-	4275_5:5242274-5242274 C>T_PPAQPSYTWAIVCSECSVSCGGGQM	0.0
4:62935916-62935916 G>A	0.0	4160	COLORECTAL	-	-	-	-	LPHN3	ENST00000514996,p.G1268S|uc010ihh.3,p.G1234S|ENST00000514591,p.G1234S|ENST00000506746,p.G1336S|ENST00000508946,p.G1277S|ENST00000506720,p.G1345S|NM_015236,p.G1234S|ENST00000507625,p.G1293S|ENST00000545650,p.G1234S|uc003hct.3,p.G618S	retained_intron, protein_coding, processed_transcript	uc010ihh.3	nonsynonymous SNV	exon23	c.G3700A	p.G1234S	NGNHGNSYSIASGEYLSNCVQIIDR	NGNHGNSYSIASSEYLSNCVQIIDR	4.0	10.0	-	-	4160_4:62935916-62935916 G>A_NGNHGNSYSIASSEYLSNCVQIIDR	0.0
4:55594007-55594007 G>C	1.0	4284	COLORECTAL	-	-	-	1	KIT	NM_001093772,p.G594A|ENST00000288135,p.G598A|uc010igs.3,p.G594A|uc010igr.3,p.G598A|ENST00000412167,p.G594A|uc010igt.2,p.G47A|NM_000222,p.G598A	retained_intron, protein_coding	uc010igt.2	nonsynonymous SNV	exon2	c.G140C	p.G47A	RNRLSFGKTLGAGAFGKVVEATAYG	RNRLSFGKTLGAAAFGKVVEATAYG	7.0	1.0	-	-	4284_4:55594007-55594007 G>C_RNRLSFGKTLGAAAFGKVVEATAYG	0.0
3:189691765-189691765 C>T	1.0	3713	MELANOMA	-	-	-	-	LEPREL1	NM_001134418,p.R313K|ENST00000427335,p.R313K|uc011bsk.2,p.R494K|NM_018192,p.R494K|uc003fsg.3,p.R313K|ENST00000319332,p.R494K	retained_intron, protein_coding	uc011bsk.2	nonsynonymous SNV	exon10	c.G1481A	p.R494K	VASGIMLVGDGYRGKTSPHTPNEKF	VASGIMLVGDGYKGKTSPHTPNEKF	2.0	2.0	-	-	3713_3:189691765-189691765 C>T_VASGIMLVGDGYKGKTSPHTPNEKF	0.0
6:165711557-165711557 T>C	0.0	4346	COLORECTAL	-	-	-	-	C6orf118	ENST00000230301,p.R324G|ENST00000543069,p.R220G|NM_144980,p.R324G|uc003qum.4,p.R324G	protein_coding, processed_transcript	uc003qum.4	nonsynonymous SNV	exon5	c.A970G	p.R324G	EALLAQLKALGQRPVKTADMDLARE	EALLAQLKALGQGPVKTADMDLARE	3.0	3.0	-	-	4346_6:165711557-165711557 T>C_EALLAQLKALGQGPVKTADMDLARE	0.0
14:92441615-92441615 G>T	1.0	4316	COLORECTAL	-	-	-	1	TRIP11	uc010auf.2,p.N1522K|uc001xzy.3,p.N1786K|ENST00000267622,p.N1786K|NM_004239,p.N1786K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010auf.2	nonsynonymous SNV	exon12	c.C4566A	p.N1522K	SSEGKVDKVLMRNLFIGHFHTPKNQ	SSEGKVDKVLMRKLFIGHFHTPKNQ	9.0	4.0	-	-	4316_14:92441615-92441615 G>T_SSEGKVDKVLMRKLFIGHFHTPKNQ	0.0
X:147743434-147743434 C>G	0.0	4160	COLORECTAL	-	-	-	-	AFF2	uc004fcq.3,p.N58K|ENST00000370457,p.N58K|uc004fcr.3,p.N58K|ENST00000370458,p.N58K|ENST00000342251,p.N58K|NM_001169122,p.N58K|uc004fco.3,p.N58K|NM_001169123,p.N58K|uc004fcs.3,p.N58K|NM_001169125,p.N58K	protein_coding	uc004fcs.3	nonsynonymous SNV	exon3	c.C174G	p.N58K	SGFDLFGEPYKTNKGDALANRVQNT	SGFDLFGEPYKTKKGDALANRVQNT	1.0	10.0	-	-	4160_X:147743434-147743434 C>G_SGFDLFGEPYKTKKGDALANRVQNT	0.0
1:109944647-109944647 G>C	1.0	4329	COLORECTAL	-	-	ID=COSM674463;OCCURENCE=1(lung)	-	PSMA5	uc021ore.1,p.I180M|uc010ovj.2,p.I180M|ENST00000538610,p.I180M|NM_001199774,p.I180M|uc001dxn.3,p.I238M|NM_001199772,p.I180M|NM_002790,p.I238M|ENST00000271308,p.I238M|NM_001199773,p.I180M|uc021ord.1,p.I180M	protein_coding, processed_transcript	uc021ore.1	nonsynonymous SNV	exon9	c.C540G	p.I180M	FHMFTKEELEEVIKDI	FHMFTKEELEEVMKDI	10.0	10.0	-	-	4329_1:109944647-109944647 G>C_FHMFTKEELEEVMKDI	0.0
5:176813558-176813558 T>C	0.0	4110	BILE DUCT	-	-	-	-	SLC34A1	uc003mgk.4,p.S175P|ENST00000512593,p.S175P|uc021yis.1,p.S175P|ENST00000324417,p.S175P|NM_003052,p.S175P|NM_001167579,p.S175P	retained_intron, protein_coding, processed_transcript	uc021yis.1	nonsynonymous SNV	exon5	c.T523C	p.S175P	SSTSTSIIVSMVSSGLLEVSSAIPI	SSTSTSIIVSMVPSGLLEVSSAIPI	1.0	6.0	-	-	4110_5:176813558-176813558 T>C_SSTSTSIIVSMVPSGLLEVSSAIPI	0.0
10:105952004-105952004 A>T	0.0	4245	COLORECTAL	-	-	-	-	CFAP43	ENST00000428666,p.I501N|ENST00000357060,p.I500N|uc001kxx.4,p.I501N|ENST00000278064,p.I431N|uc001kxw.3,p.I500N|NM_025145,p.I500N	protein_coding, processed_transcript	uc001kxx.4	nonsynonymous SNV	exon12	c.T1502A	p.I501N	FLLVGTAEGKVFIINANSSSSFQII	FLLVGTAEGKVFNINANSSSSFQII	5.0	5.0	-	-	4245_10:105952004-105952004 A>T_FLLVGTAEGKVFNINANSSSSFQII	0.0
1:35351108-35351108 G>A	0.0	4346	COLORECTAL	-	-	-	-	DLGAP3	ENST00000373347,p.R629W|uc001byc.3,p.R629W|ENST00000235180,p.R629W|NM_001080418,p.R629W	protein_coding, processed_transcript	uc001byc.3	nonsynonymous SNV	exon5	c.C1885T	p.R629W	PGREELRSLARQRKWRPSIGVQVET	PGREELRSLARQWKWRPSIGVQVET	2.0	9.0	-	-	4346_1:35351108-35351108 G>A_PGREELRSLARQWKWRPSIGVQVET	0.0
5:176885561-176885561 T>G	0.0	4245	COLORECTAL	-	-	-	-	DBN1	uc010jkn.1,p.E375A|uc003mgy.2,p.E425A|ENST00000512501,p.E157A|ENST00000309007,p.E425A|NM_004395,p.E425A|uc003mgz.1,p.E408A|uc011dga.1,p.E157A|ENST00000393565,p.E471A|NM_080881,p.E427A|uc003mgx.2,p.E427A|ENST00000292385,p.E427A|ENST00000393563,p.E157A	retained_intron, protein_coding	uc011dga.1	nonsynonymous SNV	exon5	c.A470C	p.E157A	GPGSPAEDLMFMESAEQAVLAAPVE	GPGSPAEDLMFMASAEQAVLAAPVE	8.0	3.0	-	-	4245_5:176885561-176885561 T>G_GPGSPAEDLMFMASAEQAVLAAPVE	0.0
2:182766643-182766643 G>A	1.0	3903	MELANOMA	-	-	-	-	SSFA2	NM_001287504,p.R135Q|uc002uoh.3,p.R288Q|uc002uoi.3,p.R288Q|NM_001287503,p.R288Q|ENST00000409001,p.R288Q|uc002uoj.3,p.R288Q|uc010zfo.2,p.R135Q|ENST00000320370,p.R288Q|ENST00000428267,p.R135Q|NM_001130445,p.R288Q|uc002uol.3,p.R135Q|ENST00000431877,p.R288Q|NM_006751,p.R288Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zfo.2	nonsynonymous SNV	exon7	c.G404A	p.R135Q	SNKETDPPPPLTRSNTANRLMKTLS	SNKETDPPPPLTQSNTANRLMKTLS	10.0	7.0	-	-	3903_2:182766643-182766643 G>A_SNKETDPPPPLTQSNTANRLMKTLS	0.0
5:179762845-179762845 C>T	0.0	4317	COLORECTAL	-	-	ID=COSM1436661;OCCURENCE=1(large_intestine)	-	GFPT2	ENST00000253778,p.R108H|uc003mlw.1,p.R108H|NM_005110,p.R108H	retained_intron, protein_coding, processed_transcript	uc003mlw.1	nonsynonymous SNV	exon4	c.G323A	p.R108H	HGVPSAVNSHPQRSDKGNEFVVIHN	HGVPSAVNSHPQHSDKGNEFVVIHN	4.0	5.0	-	-	4317_5:179762845-179762845 C>T_HGVPSAVNSHPQHSDKGNEFVVIHN	0.0
6:10874250-10874250 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GCM2	NM_004752,p.T500N|uc003mzn.4,p.T500N|ENST00000379491,p.T500N	protein_coding	uc003mzn.4	nonsynonymous SNV	exon5	c.C1499A	p.T500N	AVSYSDRVGPFFTYNNEDF	AVSYSDRVGPFFNYNNEDF	1.0	7.0	-	-	4258_6:10874250-10874250 G>T_AVSYSDRVGPFFNYNNEDF	0.0
7:115889146-115889146 A>T	1.0	4110	BILE DUCT	-	-	-	-	TES	uc003vho.3,p.K62N|uc010lka.2,p.K53N|NM_152829,p.K53N|NM_015641,p.K62N|ENST00000358204,p.K62N|ENST00000393481,p.K53N|uc011kmx.2,p.K62N|uc003vhp.3,p.K53N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kmx.2	nonsynonymous SNV	exon3	c.A186T	p.K62N	EHDVLLSNEEDRKVGKLFEDTKYTT	EHDVLLSNEEDRNVGKLFEDTKYTT	10.0	6.0	CD8	-	4110_7:115889146-115889146 A>T_EHDVLLSNEEDRNVGKLFEDTKYTT	2.0
7:5967982-5967982 G>T	1.0	4252	COLORECTAL	-	-	-	-	RSPH10B,RSPH10B2	uc010ktd.1,p.N759K|ENST00000404406,p.N759K|ENST00000337579,p.N759K|ENST00000405415,p.N759K|uc003sph.1,p.N759K|NM_173565,p.N759K|ENST00000441023,p.N759K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ktd.1	nonsynonymous SNV	exon19	c.C2277A	p.N759K	YERPKDDREEEFNTWVNNMYVFFVN	YERPKDDREEEFKTWVNNMYVFFVN	5.0	6.0	-	-	4252_7:5967982-5967982 G>T_YERPKDDREEEFKTWVNNMYVFFVN	0.0
8:125575189-125575189 G>T	1.0	4326	BREAST	-	-	-	-	MTSS1	uc011lin.1,p.S24Y|ENST00000325064,p.S294Y|uc003yrj.2,p.S290Y|NM_014751,p.S290Y|ENST00000522118,p.S90Y|NM_001282971,p.S294Y|NM_001282974,p.S290Y|uc003yrl.2,p.S294Y|ENST00000431961,p.S90Y|ENST00000524090,p.S180Y|ENST00000378017,p.S290Y|uc003yrk.2,p.S290Y|ENST00000395508,p.S24Y|uc003yri.2,p.S90Y|ENST00000518547,p.S290Y|ENST00000354184,p.S90Y|uc011lio.1,p.S180Y	retained_intron, protein_coding, processed_transcript	uc011lio.1	nonsynonymous SNV	exon4	c.C539A	p.S180Y	NSVNSSDSRSSGSHSHSPSSHYRYR	NSVNSSDSRSSGYHSHSPSSHYRYR	9.0	4.0	-	-	4326_8:125575189-125575189 G>T_NSVNSSDSRSSGYHSHSPSSHYRYR	0.0
1:169560673-169560673 T>A	0.0	4110	BILE DUCT	-	-	-	-	SELP	ENST00000426706,p.N769I|uc001ggh.3,p.N605I	protein_coding, processed_transcript	uc001ggh.3	nonsynonymous SNV	exon13	c.A1814T	p.N605I	VPTCQDDGKCPLNPHSHLGTYGVFT	VPTCQDDGKCPLIPHSHLGTYGVFT	1.0	6.0	-	-	4110_1:169560673-169560673 T>A_VPTCQDDGKCPLIPHSHLGTYGVFT	0.0
19:3573691-3573691 C>T	1.0	2556	MELANOMA	-	-	-	-	HMG20B	ENST00000453933,p.P14S|ENST00000416526,p.P14S|uc002lya.3,p.P14S|uc010xhn.1,p.P14S|uc010dtm.1,p.P14S|ENST00000417382,p.P14S|ENST00000435022,p.P14S|ENST00000262949,p.P14S|ENST00000333651,p.P14S|NM_006339,p.P14S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xhn.1	nonsynonymous SNV	exon2	c.C40T	p.P14S	SHGPKQPGAAAAPAGGKAPGQHGGF	SHGPKQPGAAAASAGGKAPGQHGGF	10.0	1.0	-	-	2556_19:3573691-3573691 C>T_SHGPKQPGAAAASAGGKAPGQHGGF	0.0
1:19500837-19500837 C>A	1.0	3919	MELANOMA	-	-	-	-	UBR4	NM_020765,p.K986N|ENST00000375217,p.K986N|ENST00000375254,p.K986N|uc001bbm.1,p.K197N|uc001bbi.3,p.K986N|ENST00000375267,p.K986N|ENST00000375226,p.K986N	protein_coding, processed_transcript	uc001bbm.1	nonsynonymous SNV	exon5	c.G591T	p.K197N	LAAGSQLDTVRRKENKNVTALEACA	LAAGSQLDTVRRNENKNVTALEACA	10.0	3.0	-	-	3919_1:19500837-19500837 C>A_LAAGSQLDTVRRNENKNVTALEACA	0.0
X:134166665-134166665 C>G	1.0	3775	CERVICAL	-	-	-	-	FAM127A	ENST00000257013,p.I84M|uc004eyd.3,p.I84M|NM_001078171,p.I84M	protein_coding, processed_transcript	uc004eyd.3	nonsynonymous SNV	exon1	c.C252G	p.I84M	LTGPALQWVIPYIKKESPLLNDYRG	LTGPALQWVIPYMKKESPLLNDYRG	9.0	10.0	-	-	3775_X:134166665-134166665 C>G_LTGPALQWVIPYMKKESPLLNDYRG	0.0
14:77808263-77808263 T>G	1.0	4317	COLORECTAL	-	-	-	-	TMED8	ENST00000216468,p.M277L|uc001xtn.1,p.M121L|NM_213601,p.M277L|uc001xto.1,p.M277L	protein_coding	uc001xto.1	nonsynonymous SNV	exon6	c.A829C	p.M277L	SRSSLRGRYGEVMPVYRRDSHRDVQ	SRSSLRGRYGEVLPVYRRDSHRDVQ	4.0	7.0	-	-	4317_14:77808263-77808263 T>G_SRSSLRGRYGEVLPVYRRDSHRDVQ	0.0
7:128588330-128588330 G>A	1.0	2591	MELANOMA	-	-	-	-	IRF5	uc003voh.3,p.G400E|ENST00000477535,p.G314E|ENST00000249375,p.G400E|NM_001242452,p.G314E|NM_001098630,p.G400E|uc003voi.3,p.G400E|ENST00000357234,p.G416E|uc010llt.3,p.G314E|NM_001098629,p.G416E|uc003voj.4,p.G400E|ENST00000473745,p.G400E|NM_001098627,p.G400E|ENST00000402030,p.G400E|NM_032643,p.G400E|uc003vog.3,p.G416E	retained_intron, protein_coding, nonsense_mediated_decay	uc010llt.3	nonsynonymous SNV	exon7	c.G941A	p.G314E	NTPPPFEIFFCFGEEWPDRKPREKK	NTPPPFEIFFCFEEEWPDRKPREKK	4.0	10.0	-	-	2591_7:128588330-128588330 G>A_NTPPPFEIFFCFEEEWPDRKPREKK	0.0
21:35469257-35469257 C>T	1.0	3879	MELANOMA	-	-	-	-	SLC5A3	uc021wir.1,p.P587L|uc002yto.3,p.P587L|NM_006933,p.P587L|ENST00000381151,p.P587L	protein_coding	uc021wir.1	nonsynonymous SNV	exon1	c.C1760T	p.P587L	CSENNETINHIIPNGKSEDSIKGLQ	CSENNETINHIILNGKSEDSIKGLQ	9.0	9.0	CD8	-	3879_21:35469257-35469257 C>T_CSENNETINHIILNGKSEDSIKGLQ	2.0
11:1262392-1262392 G>A	0.0	3919	MELANOMA	-	-	-	-	MUC5B	uc001lta.3,p.E1428K|ENST00000529681,p.E1428K|ENST00000447027,p.E1431K|NM_002458,p.E1428K	retained_intron, protein_coding, processed_transcript	uc001lta.3	nonsynonymous SNV	exon31	c.G4282A	p.E1428K	LCHDYELRVLCCEYVPCGPSPAPGT	LCHDYELRVLCCKYVPCGPSPAPGT	3.0	9.0	-	-	3919_11:1262392-1262392 G>A_LCHDYELRVLCCKYVPCGPSPAPGT	0.0
4:129019407-129019407 A>C	1.0	4320	COLORECTAL	-	-	-	-	LARP1B	ENST00000432347,p.Q245H|uc003ifx.3,p.Q245H|NM_001278604,p.Q245H|ENST00000427266,p.Q245H|ENST00000394288,p.Q245H|NM_018078,p.Q245H|NM_032239,p.Q245H|ENST00000264584,p.Q198H|ENST00000441387,p.Q245H|uc003ifw.1,p.Q198H|NM_178043,p.Q245H|uc003ify.3,p.Q245H|ENST00000512292,p.Q245H|uc003ifz.1,p.Q245H|uc003iga.3,p.Q245H|ENST00000508819,p.Q198H|ENST00000326639,p.Q245H	protein_coding, processed_transcript, nonsense_mediated_decay	uc003iga.3	nonsynonymous SNV	exon8	c.A735C	p.Q245H	ERDFFLRGKMDEQGFLPISLIAGFQ	ERDFFLRGKMDEHGFLPISLIAGFQ	8.0	7.0	-	-	4320_4:129019407-129019407 A>C_ERDFFLRGKMDEHGFLPISLIAGFQ	0.0
19:46807177-46807177 G>A	1.0	3784	MELANOMA	-	-	-	-	HIF3A	ENST00000300862,p.E15K|uc002pel.3,p.E15K|NM_152794,p.E15K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002pel.3	nonsynonymous SNV	exon2	c.G43A	p.E15K	WQDHRSTTELRKEKSRDAARSRRSQ	WQDHRSTTELRKKKSRDAARSRRSQ	6.0	9.0	-	-	3784_19:46807177-46807177 G>A_WQDHRSTTELRKKKSRDAARSRRSQ	0.0
X:41203555-41203556 AT>-	1.0	3879	MELANOMA	-	-	-	1	DDX3X	ENST00000457138,p.I294fs|uc011mkr.2,p.I310fs|NM_001356,p.I310fs|uc011mkq.2,p.I294fs|NM_001193416,p.I310fs|uc004dfe.3,p.I310fs|ENST00000399959,p.I310fs|NM_001193417,p.I294fs|uc004dff.3,p.I310fs	protein_coding, processed_transcript	uc011mkr.2	frameshift deletion	exon10	c.928_929del	p.I310fs	CVVYGGADIGQQIRDLERGCHLLVA	CVVYGGADIGQQSRLGTWMPFVSSHSRTSSGYDGKRKDWIRLLQILGVR	9.0	2.0	-	-	3879_X:41203555-41203556 AT>-_CVVYGGADIGQQSRLGTWMPFVSSHSRTSSGYDGKRKDWIRLLQILGVR	0.0
11:55861283-55861283 C>A	0.0	4298	COLORECTAL	-	-	-	-	OR8I2	uc010rix.2,p.A167E|ENST00000560768,p.A167E|ENST00000302124,p.A167E|NM_001003750,p.A167E	protein_coding	uc010rix.2	nonsynonymous SNV	exon1	c.C500A	p.A167E	SSLISVWVISSLAFCDSSINHFFCD	SSLISVWVISSLEFCDSSINHFFCD	1.0	7.0	-	-	4298_11:55861283-55861283 C>A_SSLISVWVISSLEFCDSSINHFFCD	0.0
5:13914689-13914689 G>C	0.0	4298	COLORECTAL	-	-	-	-	DNAH5	ENST00000265104,p.I420M|NM_001369,p.I420M|uc003jfd.2,p.I420M	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon10	c.C1260G	p.I420M	CKAYITNNGTASIWNQPQDVVEEKI	CKAYITNNGTASMWNQPQDVVEEKI	4.0	5.0	-	-	4298_5:13914689-13914689 G>C_CKAYITNNGTASMWNQPQDVVEEKI	0.0
17:36718350-36718350 T>C	1.0	4345	COLORECTAL	-	-	-	-	SRCIN1	uc002hqd.3,p.E350G|ENST00000264659,p.E350G|NM_025248,p.E350G|uc002hqe.2,p.E204G|ENST00000578925,p.E384G|ENST00000584266,p.E410G|uc002hqh.1,p.E410G|uc002hqf.1,p.E222G	retained_intron, protein_coding, processed_transcript	uc002hqh.1	nonsynonymous SNV	exon7	c.A1229G	p.E410G	PSYAGSPVHHAAERLGGAPAAQGVS	PSYAGSPVHHAAGRLGGAPAAQGVS	5.0	6.0	-	-	4345_17:36718350-36718350 T>C_PSYAGSPVHHAAGRLGGAPAAQGVS	0.0
X:10176241-10176241 C>T	1.0	2369	MELANOMA	-	-	-	-	CLCN4	ENST00000421085,p.P240S|uc004csy.4,p.P334S|NM_001256944,p.P240S|NM_001830,p.P334S|ENST00000380833,p.P334S|uc011mid.3,p.P240S	protein_coding	uc011mid.3	nonsynonymous SNV	exon7	c.C718T	p.P240S	EYHTPWYMAELFPFILLGVFGGLWG	EYHTPWYMAELFSFILLGVFGGLWG	6.0	10.0	-	-	2369_X:10176241-10176241 C>T_EYHTPWYMAELFSFILLGVFGGLWG	0.0
20:32026691-32026691 G>A	1.0	4252	COLORECTAL	-	-	-	-	SNTA1	uc002wzd.1,p.A151V|ENST00000217381,p.A151V|NM_003098,p.A151V|uc010zuf.1,p.A151V	protein_coding	uc010zuf.1	nonsynonymous SNV	exon2	c.C452T	p.A151V	NGEDLSSATHDEAVQVLKKTGKEVV	NGEDLSSATHDEVVQVLKKTGKEVV	7.0	7.0	-	-	4252_20:32026691-32026691 G>A_NGEDLSSATHDEVVQVLKKTGKEVV	0.0
2:49190317-49190317 C>T	0.0	4284	COLORECTAL	-	-	-	-	FSHR	ENST00000346173,p.C486Y|uc002rwx.3,p.C486Y|NM_000145,p.C548Y|ENST00000406846,p.C548Y|ENST00000304421,p.C522Y|uc010fbn.3,p.C522Y|uc002rww.3,p.C548Y|ENST00000541117,p.C284Y|NM_181446,p.C522Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc010fbn.3	nonsynonymous SNV	exon9	c.G1565A	p.C522Y	VLNVLAFVVICGCYIHIYLTVRNPN	VLNVLAFVVICGYYIHIYLTVRNPN	2.0	3.0	-	-	4284_2:49190317-49190317 C>T_VLNVLAFVVICGYYIHIYLTVRNPN	0.0
7:150094539-150094539 T>G	1.0	4213	COLORECTAL	-	-	-	-	ZNF775	ENST00000329630,p.L324V|NM_173680,p.L324V|uc003whf.1,p.L324V	protein_coding, processed_transcript	uc003whf.1	nonsynonymous SNV	exon3	c.T970G	p.L324V	PECGRRFSQKPNLTRHLRNHTGERP	PECGRRFSQKPNVTRHLRNHTGERP	9.0	5.0	-	-	4213_7:150094539-150094539 T>G_PECGRRFSQKPNVTRHLRNHTGERP	0.0
2:120005729-120005729 T>A	1.0	4071	COLORECTAL	-	-	-	-	STEAP3	ENST00000354888,p.L323M|ENST00000425223,p.L323M|ENST00000393108,p.L323M|ENST00000393106,p.L323M|NM_182915,p.L333M|uc002tlp.3,p.L323M|uc010fle.3,p.L323M|NM_018234,p.L323M|ENST00000393110,p.L333M|ENST00000393107,p.L323M|NM_001008410,p.L323M|ENST00000450943,p.L323M|uc002tlq.3,p.L333M|ENST00000409811,p.L323M|uc002tlr.3,p.L323M	protein_coding	uc010fle.3	nonsynonymous SNV	exon3	c.T967A	p.L323M	FCAALHALYSFCLPLRRAHRYDLVN	FCAALHALYSFCMPLRRAHRYDLVN	8.0	8.0	-	-	4071_2:120005729-120005729 T>A_FCAALHALYSFCMPLRRAHRYDLVN	0.0
5:3599454-3599454 C>A	0.0	4110	BILE DUCT	-	-	-	-	IRX1	NM_024337,p.P131H|uc003jde.3,p.P131H|ENST00000302006,p.P131H	protein_coding	uc003jde.3	nonsynonymous SNV	exon2	c.C392A	p.P131H	PYGQFQYGDPGRPKNATRESTSTLK	PYGQFQYGDPGRHKNATRESTSTLK	1.0	8.0	-	-	4110_5:3599454-3599454 C>A_PYGQFQYGDPGRHKNATRESTSTLK	0.0
21:15599340-15599340 A>G	1.0	4301	MELANOMA	-	-	-	-	RBM11	uc002yjo.4,p.H191R|uc002yjn.4,p.H77R|NM_144770,p.H191R|ENST00000400577,p.H191R|uc002yjp.4,p.H77R	retained_intron, protein_coding, processed_transcript	uc002yjp.4	nonsynonymous SNV	exon4	c.A230G	p.H77R	DLEAGPSSYKWTHQQPSDSDLYQMT	DLEAGPSSYKWTRQQPSDSDLYQMT	7.0	2.0	-	-	4301_21:15599340-15599340 A>G_DLEAGPSSYKWTRQQPSDSDLYQMT	0.0
2:27247103-27247103 C>T	1.0	4149	OVARIAN	-	-	-	-	MAPRE3	ENST00000233121,p.A136V|ENST00000458529,p.A136V|NM_012326,p.A136V|uc002rhw.3,p.A136V	retained_intron, protein_coding, processed_transcript	uc002rhw.3	nonsynonymous SNV	exon4	c.C407T	p.A136V	YNPLLARQGQDVAPPPNPGDQIFNK	YNPLLARQGQDVVPPPNPGDQIFNK	8.0	5.0	-	-	4149_2:27247103-27247103 C>T_YNPLLARQGQDVVPPPNPGDQIFNK	0.0
5:60839843-60839843 C>T	1.0	4000	MELANOMA	-	-	-	-	ZSWIM6	ENST00000252744,p.P1116L|NM_020928,p.P1116L|uc003jsr.3,p.P1116L	protein_coding	uc003jsr.3	nonsynonymous SNV	exon14	c.C3347T	p.P1116L	LSDILRRCTLTTPGMVGLHGRRNSG	LSDILRRCTLTTLGMVGLHGRRNSG	8.0	2.0	-	-	4000_5:60839843-60839843 C>T_LSDILRRCTLTTLGMVGLHGRRNSG	0.0
20:44528512-44528512 C>T	1.0	4189	MELANOMA	-	-	-	-	PLTP	ENST00000542937,p.R414Q|ENST00000477313,p.R394Q|NM_182676,p.R342Q|ENST00000354050,p.R342Q|ENST00000420868,p.R299Q|NM_001242920,p.R299Q|uc002xqn.2,p.R394Q|uc002xqq.2,p.R363Q|uc002xql.2,p.R306Q|ENST00000372431,p.R394Q|NM_006227,p.R394Q|uc010zxj.2,p.R299Q|uc002xqm.2,p.R414Q|ENST00000372420,p.R306Q|NM_001242921,p.R306Q|uc002xqo.2,p.R342Q	protein_coding	uc010zxj.2	nonsynonymous SNV	exon11	c.G896A	p.R299Q	KALRTQLDLRRFRIYSNHSALESLA	KALRTQLDLRRFQIYSNHSALESLA	10.0	2.0	-	-	4189_20:44528512-44528512 C>T_KALRTQLDLRRFQIYSNHSALESLA	0.0
6:166580091-166580091 C>T	0.0	4275	COLORECTAL	-	-	-	-	T	ENST00000366871,p.G154R|ENST00000461348,p.G154R|ENST00000296946,p.G154R|uc003qut.2,p.G154R|NM_003181,p.G154R|uc003quv.2,p.G154R|NM_001270484,p.G154R|uc003quu.2,p.G154R|ENST00000366876,p.G154R	protein_coding	uc003quv.2	nonsynonymous SNV	exon3	c.G460A	p.G154R	SFSKVKLTNKLNGGGQIMLNSLHKY	SFSKVKLTNKLNRGGQIMLNSLHKY	2.0	2.0	-	-	4275_6:166580091-166580091 C>T_SFSKVKLTNKLNRGGQIMLNSLHKY	0.0
17:11672508-11672508 C>T	0.0	4213	COLORECTAL	-	-	-	-	DNAH9	ENST00000454412,p.R2472W|NM_001372,p.R2472W|uc002gne.3,p.R2472W|uc010coo.3,p.R1766W|ENST00000262442,p.R2472W	retained_intron, protein_coding, processed_transcript	uc010coo.3	nonsynonymous SNV	exon26	c.C5296T	p.R1766W	VCYFMERLMARQRPVMLVGTAGTGK	VCYFMERLMARQWPVMLVGTAGTGK	5.0	6.0	-	-	4213_17:11672508-11672508 C>T_VCYFMERLMARQWPVMLVGTAGTGK	0.0
7:2581000-2581000 G>A	1.0	3784	MELANOMA	-	-	-	-	BRAT1	NM_152743,p.T418I|uc003smi.3,p.T418I|ENST00000340611,p.T418I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003smi.3	nonsynonymous SNV	exon9	c.C1253T	p.T418I	APASSVGGHLCGTLAGCVRVQRAAL	APASSVGGHLCGILAGCVRVQRAAL	7.0	10.0	-	-	3784_7:2581000-2581000 G>A_APASSVGGHLCGILAGCVRVQRAAL	0.0
1:228598777-228598777 G>T	1.0	4177	PANCREATIC	-	-	-	-	TRIM17	uc009xfb.2,p.T209K|ENST00000366698,p.T209K|NM_001024940,p.T209K|NM_016102,p.T209K|ENST00000479800,p.T182K|ENST00000295033,p.T209K|uc001hsu.3,p.T209K|ENST00000366697,p.T209K|ENST00000456946,p.T209K|NM_001134855,p.T209K|uc001hsv.3,p.T209K	protein_coding	uc009xfb.2	nonsynonymous SNV	exon4	c.C626A	p.T209K	VEEEQRLLQALETEEEETASRLRES	VEEEQRLLQALEKEEEETASRLRES	4.0	7.0	-	-	4177_1:228598777-228598777 G>T_VEEEQRLLQALEKEEEETASRLRES	0.0
10:13151129-13151129 C>T	1.0	3903	MELANOMA	-	-	-	-	OPTN	uc001ilu.1,p.H3Y|NM_021980,p.H3Y|ENST00000378747,p.H3Y|ENST00000263036,p.H3Y|uc001ily.1,p.H3Y|uc001ilw.1,p.H3Y|NM_001008212,p.H3Y|NM_001008211,p.H3Y|ENST00000378764,p.H3Y|ENST00000378757,p.H3Y|ENST00000378752,p.H3Y|uc001ilv.1,p.H3Y|uc001ilx.1,p.H3Y|NM_001008213,p.H3Y|ENST00000378748,p.H3Y	protein_coding, processed_transcript	uc001ily.1	nonsynonymous SNV	exon4	c.C7T	p.H3Y	MSHQPLSCLTEKEDS	MSYQPLSCLTEKEDS	8.0	10.0	-	-	3903_10:13151129-13151129 C>T_MSYQPLSCLTEKEDS	0.0
7:25176114-25176114 G>T	1.0	4000	MELANOMA	-	-	-	-	C7orf31	NM_138811,p.T417K|ENST00000409280,p.T417K|uc003sxn.1,p.T417K|ENST00000283905,p.T417K	protein_coding	uc003sxn.1	nonsynonymous SNV	exon10	c.C1250A	p.T417K	LLSTYELPSCYPTKDLTSIYDIKPF	LLSTYELPSCYPKKDLTSIYDIKPF	7.0	6.0	-	-	4000_7:25176114-25176114 G>T_LLSTYELPSCYPKKDLTSIYDIKPF	0.0
2:179431472-179431472 C>T	0.0	3775	CERVICAL	-	-	-	-	TTN	uc021vta.2,p.A17523T|NM_001256850,p.A24822T|ENST00000342992,p.A23895T|uc031rqc.1,p.A26463T|ENST00000591111,p.A24822T|uc021vtb.2,p.A17398T|uc031rqd.1,p.A24822T|uc021vsz.2,p.A17590T|NM_133437,p.A17590T|uc021vsy.2,p.A23895T|ENST00000589042,p.A26463T|ENST00000460472,p.A17398T|ENST00000359218,p.A17523T|NM_133378,p.A23895T|NM_001267550,p.A26463T|NM_003319,p.A17398T|ENST00000342175,p.A17590T|NM_133432,p.A17523T	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon276	c.G74464A	p.A24822T	LTEDHEYEFRVSAENAAGVGEPSPA	LTEDHEYEFRVSTENAAGVGEPSPA	2.0	8.0	-	-	3775_2:179431472-179431472 C>T_LTEDHEYEFRVSTENAAGVGEPSPA	0.0
11:120999042-120999042 T>A	0.0	4160	COLORECTAL	-	-	-	-	TECTA	NM_005422,p.S786T|ENST00000392793,p.S786T|ENST00000264037,p.S786T|uc010rzo.2,p.S786T	protein_coding, processed_transcript	uc010rzo.2	nonsynonymous SNV	exon8	c.T2356A	p.S786T	ADQEVKIGGIGASEVKLNGQEVELP	ADQEVKIGGIGATEVKLNGQEVELP	1.0	3.0	-	-	4160_11:120999042-120999042 T>A_ADQEVKIGGIGATEVKLNGQEVELP	0.0
16:722106-722106 C>T	1.0	2369	MELANOMA	-	-	-	-	RHOT2	uc002ciq.3,p.R267W|ENST00000315082,p.R374W|NM_138769,p.R374W|uc002cip.3,p.R374W|uc010bqy.3,p.R153W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bqy.3	nonsynonymous SNV	exon4	c.C457T	p.R153W	LCQWTLVTYLDVRSCLGHLGYLGYP	LCQWTLVTYLDVWSCLGHLGYLGYP	10.0	8.0	-	-	2369_16:722106-722106 C>T_LCQWTLVTYLDVWSCLGHLGYLGYP	0.0
10:16737059-16737059 G>A	1.0	4189	MELANOMA	-	-	-	-	RSU1	NM_012425,p.H232Y|ENST00000345264,p.H232Y|uc001iom.3,p.H179Y|NM_152724,p.H179Y|uc001iol.3,p.H232Y|ENST00000602389,p.H179Y|uc001iok.3,p.H232Y|ENST00000377921,p.H232Y	protein_coding, nonsense_mediated_decay	uc001iom.3	nonsynonymous SNV	exon7	c.C535T	p.H179Y	TPIADQFQLGVSHVFEYIRSETYKY	TPIADQFQLGVSYVFEYIRSETYKY	10.0	8.0	-	-	4189_10:16737059-16737059 G>A_TPIADQFQLGVSYVFEYIRSETYKY	0.0
16:27495532-27495532 T>C	0.0	4345	COLORECTAL	-	-	-	-	GTF3C1	NM_001520,p.K1334R|ENST00000561623,p.K1334R|uc002dov.2,p.K1334R|uc002dou.3,p.K1334R|ENST00000356183,p.K1334R|NM_001286242,p.K1334R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dov.2	nonsynonymous SNV	exon25	c.A4001G	p.K1334R	YIVKNPQAYLNYKVCLAEVYQDKAL	YIVKNPQAYLNYRVCLAEVYQDKAL	7.0	2.0	-	-	4345_16:27495532-27495532 T>C_YIVKNPQAYLNYRVCLAEVYQDKAL	0.0
19:43585265-43585265 G>C	0.0	4186	BREAST	-	-	-	-	PSG2	NM_031246,p.I66M|ENST00000406487,p.I66M|uc002ovr.3,p.I66M	protein_coding, processed_transcript	uc002ovr.3	nonsynonymous SNV	exon2	c.C198G	p.I66M	LVHNLPQNLTGYIWYKGQIRDLYHY	LVHNLPQNLTGYMWYKGQIRDLYHY	1.0	4.0	-	-	4186_19:43585265-43585265 G>C_LVHNLPQNLTGYMWYKGQIRDLYHY	0.0
7:44286784-44286784 T>C	0.0	4275	COLORECTAL	-	-	-	-	CAMK2B	ENST00000346990,p.I117V|ENST00000350811,p.I117V|NM_001293170,p.I117V|ENST00000347193,p.I117V|ENST00000440254,p.I117V|ENST00000395749,p.I117V|ENST00000358707,p.I117V|uc003tkv.2,p.I117V|uc003tkp.2,p.I117V|uc003tkr.2,p.I117V|NM_172083,p.I117V|uc003tks.2,p.I117V|NM_172082,p.I117V|ENST00000353185,p.I117V|ENST00000421607,p.I117V|NM_172081,p.I117V|ENST00000415369,p.I133V|ENST00000395747,p.I117V|ENST00000258682,p.I117V|ENST00000353625,p.I117V|ENST00000457475,p.I117V|uc003tkq.2,p.I117V|uc010kyc.2,p.I117V|NM_172079,p.I117V|NM_001220,p.I117V|NM_172080,p.I117V|uc003tkw.2,p.I117V|uc003tkt.2,p.I117V|NM_172084,p.I117V|uc003tku.2,p.I117V|NM_172078,p.I117V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kyc.2	nonsynonymous SNV	exon6	c.A349G	p.I117V	REYYSEADASHCIQQILEAVLHCHQ	REYYSEADASHCVQQILEAVLHCHQ	4.0	1.0	-	-	4275_7:44286784-44286784 T>C_REYYSEADASHCVQQILEAVLHCHQ	0.0
12:12815259-12815259 C>T	1.0	2591	MELANOMA	-	-	-	-	GPR19	uc001rar.3,p.E42K|ENST00000332427,p.E42K|ENST00000540796,p.E42K|uc001raq.2,p.E42K|uc021qvj.1,p.E42K|NM_006143,p.E42K|ENST00000540510,p.E42K	protein_coding, processed_transcript	uc021qvj.1	nonsynonymous SNV	exon1	c.G124A	p.E42K	ETATPLPSQYLMELSEEHSWMSNQT	ETATPLPSQYLMKLSEEHSWMSNQT	4.0	6.0	-	-	2591_12:12815259-12815259 C>T_ETATPLPSQYLMKLSEEHSWMSNQT	0.0
12:59272636-59272636 T>C	1.0	4266	COLORECTAL	-	-	-	1	LRIG3	uc009zqh.3,p.I625V|ENST00000320743,p.I685V|NM_153377,p.I685V|uc001sqr.4,p.I685V|ENST00000379141,p.I625V|NM_001136051,p.I625V	retained_intron, protein_coding, nonsense_mediated_decay	uc009zqh.3	nonsynonymous SNV	exon14	c.A1873G	p.I625V	VYSCTAQNSAGSISANATLTVLETP	VYSCTAQNSAGSVSANATLTVLETP	7.0	6.0	-	-	4266_12:59272636-59272636 T>C_VYSCTAQNSAGSVSANATLTVLETP	0.0
14:50218375-50218375 T>G	0.0	4335	COLORECTAL	-	-	-	-	KLHDC1	NM_172193,p.L369R|ENST00000359332,p.L369R|uc001www.3,p.L369R|uc010tqh.2,p.L284R|uc010tqg.2,p.L324R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010tqh.2	nonsynonymous SNV	exon13	c.T851G	p.L284R	MLESQISLLPPKLLQQVLKKITFWA	MLESQISLLPPKRLQQVLKKITFWA	6.0	6.0	-	-	4335_14:50218375-50218375 T>G_MLESQISLLPPKRLQQVLKKITFWA	0.0
7:140301488-140301488 C>A	1.0	3919	MELANOMA	-	-	-	-	DENND2A	ENST00000537639,p.G237V|ENST00000492720,p.G237V|ENST00000461883,p.G237V|uc003vvw.3,p.G237V|uc010lnj.3,p.G237V|uc010lnk.3,p.G237V|ENST00000496613,p.G237V|NM_015689,p.G237V|ENST00000275884,p.G237V|uc003vvx.3,p.G237V	protein_coding, nonsense_mediated_decay	uc010lnk.3	nonsynonymous SNV	exon3	c.G710T	p.G237V	REPTPELVEDRKGSCRRPWDRSLEN	REPTPELVEDRKVSCRRPWDRSLEN	5.0	1.0	-	-	3919_7:140301488-140301488 C>A_REPTPELVEDRKVSCRRPWDRSLEN	0.0
22:19434915-19434915 T>C	1.0	4189	MELANOMA	-	-	-	-	C22orf39	NM_001166242,p.N97D|ENST00000399568,p.N60D|uc002zpi.3,p.N97D|ENST00000542103,p.N97D	protein_coding, processed_transcript, nonsense_mediated_decay	uc002zpi.3	nonsynonymous SNV	exon2	c.A289G	p.N97D	DLASCRDWEERRNAEAQVLSVVAHT	DLASCRDWEERRDAEAQVLSVVAHT	8.0	7.0	-	-	4189_22:19434915-19434915 T>C_DLASCRDWEERRDAEAQVLSVVAHT	0.0
3:122437754-122437754 A>G	1.0	3678	MELANOMA	-	-	-	-	PARP14	uc003efs.1,p.T1303A|uc003efq.4,p.T1586A|ENST00000474629,p.T1586A|ENST00000460683,p.T1427A|NM_017554,p.T1586A|uc021xdc.1,p.T1450A|uc003efr.3,p.T1303A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xdc.1	nonsynonymous SNV	exon11	c.A4348G	p.T1450A	RHYTVNLNTYTATDTKGHSLSVQRL	RHYTVNLNTYTAADTKGHSLSVQRL	10.0	1.0	-	-	3678_3:122437754-122437754 A>G_RHYTVNLNTYTAADTKGHSLSVQRL	0.0
7:120446742-120446742 T>G	1.0	4078	GASTRIC	-	-	-	-	TSPAN12	ENST00000415871,p.K158T|uc010lkj.3,p.K31T|uc003vjk.3,p.K158T|NM_012338,p.K158T|ENST00000222747,p.K158T	protein_coding, nonsense_mediated_decay	uc010lkj.3	nonsynonymous SNV	exon3	c.A92C	p.K31T	LTHAWNFFQREFKCCGVVYFTDWLE	LTHAWNFFQREFTCCGVVYFTDWLE	5.0	7.0	-	-	4078_7:120446742-120446742 T>G_LTHAWNFFQREFTCCGVVYFTDWLE	0.0
4:8456500-8456500 G>A	1.0	3903	MELANOMA	-	-	ID=COSM1694143,COSM1694144;OCCURENCE=1(skin)	-	TRMT44	ENST00000389737,p.R388K|ENST00000513449,p.R147K|NM_152544,p.R388K|uc003glg.2,p.R388K|uc003glf.1,p.R147K	retained_intron, protein_coding, processed_transcript	uc003glg.2	nonsynonymous SNV	exon6	c.G1163A	p.R388K	EGHPGRGIDVRRRKIWDMYGPQTQL	EGHPGRGIDVRRKKIWDMYGPQTQL	6.0	7.0	-	-	3903_4:8456500-8456500 G>A_EGHPGRGIDVRRKKIWDMYGPQTQL	0.0
2:173891885-173891885 G>T	0.0	4266	COLORECTAL	-	-	ID=COSM1663827;OCCURENCE=1(kidney)	-	RAPGEF4	ENST00000539331,p.R666I|ENST00000409036,p.R819I|NM_001282900,p.R648I|ENST00000538974,p.R648I|ENST00000540783,p.R666I|uc002uhv.4,p.R819I|NM_001282899,p.R666I|ENST00000535187,p.R599I|ENST00000397085,p.R50I|ENST00000264111,p.R818I|NM_007023,p.R819I|uc002uhw.4,p.R675I|ENST00000397081,p.R819I|NM_001100397,p.R675I|NM_001282901,p.R599I|ENST00000397087,p.R675I	retained_intron, protein_coding, processed_transcript	uc002uhw.4	nonsynonymous SNV	exon22	c.G2024T	p.R675I	KKTTANLDLFLRRFNEIQFWVVTEI	KKTTANLDLFLRIFNEIQFWVVTEI	6.0	4.0	-	-	4266_2:173891885-173891885 G>T_KKTTANLDLFLRIFNEIQFWVVTEI	0.0
2:162696425-162696425 G>A	0.0	3903	MELANOMA	-	-	ID=COSM3748711,COSM385342,COSM3748712;OCCURENCE=1(lung),1(stomach)	-	SLC4A10	NM_001178016,p.R146Q|ENST00000272716,p.R135Q|ENST00000375514,p.R146Q|uc010fpa.1,p.R147Q|NM_001178015,p.R135Q|ENST00000415876,p.R135Q|ENST00000535165,p.R135Q|uc010zcs.2,p.R146Q|uc002uby.4,p.R135Q|ENST00000421911,p.R135Q|ENST00000446997,p.R135Q|ENST00000446228,p.R135Q|uc002ubx.4,p.R135Q|NM_022058,p.R135Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zcs.2	nonsynonymous SNV	exon5	c.G437A	p.R146Q	EICWREGEDAEWRETARWLKFEEDV	EICWREGEDAEWQETARWLKFEEDV	1.0	8.0	-	-	3903_2:162696425-162696425 G>A_EICWREGEDAEWQETARWLKFEEDV	0.0
20:47850238-47850238 T>C	1.0	4180	BREAST	-	-	-	-	DDX27	NM_017895,p.I453T|ENST00000371764,p.I453T|uc002xuh.3,p.I453T	protein_coding, processed_transcript	uc002xuh.3	nonsynonymous SNV	exon11	c.T1358C	p.I453T	RIRPNREGDREAIVAALLTRTFTDH	RIRPNREGDREATVAALLTRTFTDH	10.0	8.0	-	-	4180_20:47850238-47850238 T>C_RIRPNREGDREATVAALLTRTFTDH	0.0
9:1056832-1056832 T>G	1.0	3678	MELANOMA	-	-	-	-	DMRT2	NM_181872,p.S415R|uc003zha.3,p.S415R|ENST00000302441,p.S415R|ENST00000358146,p.S415R|uc011llv.2,p.S415R|uc003zgy.4,p.S259R|ENST00000382251,p.S415R	protein_coding	uc011llv.2	nonsynonymous SNV	exon3	c.T1245G	p.S415R	VLPHTPEIQTTRSDLQGHQAVPERS	VLPHTPEIQTTRRDLQGHQAVPERS	4.0	9.0	-	-	3678_9:1056832-1056832 T>G_VLPHTPEIQTTRRDLQGHQAVPERS	0.0
12:121880168-121880168 G>T	1.0	4252	COLORECTAL	-	-	-	-	KDM2B	uc010szx.2,p.P274T|uc001uaq.3,p.P466T|uc010szy.2,p.P466T|NM_001005366,p.P957T|uc021rfe.1,p.P1026T|ENST00000542973,p.P394T|ENST00000377071,p.P1026T|uc021rfd.1,p.P957T|ENST00000377069,p.P957T|NM_032590,p.P1026T|uc001uao.3,p.P274T|uc001uas.3,p.P957T|uc001uat.3,p.P1026T|uc001uar.3,p.P617T	retained_intron, protein_coding, nonsense_mediated_decay	uc021rfe.1	nonsynonymous SNV	exon19	c.C3076A	p.P1026T	PSLRSPPRVISRPPPSVSPPKCIQM	PSLRSPPRVISRTPPSVSPPKCIQM	7.0	9.0	-	-	4252_12:121880168-121880168 G>T_PSLRSPPRVISRTPPSVSPPKCIQM	0.0
6:43155493-43155493 G>A	1.0	3713	MELANOMA	-	-	-	-	CUL9	uc003ouk.3,p.E542K|NM_015089,p.E542K|uc003oul.3,p.E542K|ENST00000252050,p.E542K|uc003ouj.1,p.E432K|ENST00000372647,p.E542K|ENST00000354495,p.E432K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003oul.3	nonsynonymous SNV	exon7	c.G1624A	p.E542K	GEKALGEISVSVEMAESLLQVLSSR	GEKALGEISVSVKMAESLLQVLSSR	8.0	9.0	-	-	3713_6:43155493-43155493 G>A_GEKALGEISVSVKMAESLLQVLSSR	0.0
12:12977591-12977591 G>C	0.0	4110	BILE DUCT	-	-	-	-	DDX47	ENST00000352940,p.D290H|uc001ray.3,p.D290H|NM_201224,p.D290H|ENST00000358007,p.D339H|NM_016355,p.D339H|uc001rax.3,p.D339H|uc001rav.3,p.D339H	retained_intron, protein_coding, processed_transcript	uc001ray.3	nonsynonymous SNV	exon8	c.G868C	p.D290H	LDIPHVDVVVNFDIPTHSKDYIHRV	LDIPHVDVVVNFHIPTHSKDYIHRV	10.0	6.0	-	-	4110_12:12977591-12977591 G>C_LDIPHVDVVVNFHIPTHSKDYIHRV	0.0
6:31498645-31498645 T>C	1.0	4287	COLORECTAL	-	-	-	-	DDX39B	uc003ntu.3,p.E394G|uc003ntr.3,p.E201G|uc003ntt.3,p.E394G|ENST00000458640,p.E394G|uc011dnn.2,p.E316G|ENST00000417556,p.E409G|ENST00000415382,p.E316G|ENST00000396172,p.E394G|NM_080598,p.E394G|uc003ntv.3,p.E394G|NM_004640,p.E394G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011dnn.2	nonsynonymous SNV	exon8	c.A947G	p.E316G	GTKGLAITFVSDENDAKILNDVQDR	GTKGLAITFVSDGNDAKILNDVQDR	10.0	1.0	-	-	4287_6:31498645-31498645 T>C_GTKGLAITFVSDGNDAKILNDVQDR	0.0
11:58384671-58384671 G>A	1.0	4234	NSCLC	-	-	ID=COSM543754,COSM543755;OCCURENCE=1(lung)	-	ZFP91	ENST00000316059,p.C402Y|ENST00000389919,p.C402Y|uc001nmy.4,p.C401Y|NM_053023,p.C402Y|uc001nmx.4,p.C402Y|ENST00000422974,p.C229Y|NM_001197051,p.C401Y	protein_coding	uc001nmy.4	nonsynonymous SNV	exon11	c.G1202A	p.C401Y	HRMIHTGEKPLQCEICGFTCRQKAS	HRMIHTGEKPLQYEICGFTCRQKAS	8.0	1.0	-	-	4234_11:58384671-58384671 G>A_HRMIHTGEKPLQYEICGFTCRQKAS	0.0
6:152605135-152605135 G>A	0.0	4287	COLORECTAL	0.0009	-	-	-	SYNE1	uc003qos.4,p.S586L|ENST00000448038,p.S5991L|ENST00000265368,p.S6062L|ENST00000423061,p.S5991L|uc003qot.4,p.S5991L|uc003qou.4,p.S6062L|NM_033071,p.S5991L|ENST00000367255,p.S6062L|ENST00000356820,p.S586L|ENST00000341594,p.S5674L|uc010kiy.1,p.S241L|NM_182961,p.S6062L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kiy.1	nonsynonymous SNV	exon4	c.C722T	p.S241L	LAERMSTIRMKASGKRQLLEEKLND	LAERMSTIRMKALGKRQLLEEKLND	7.0	10.0	-	-	4287_6:152605135-152605135 G>A_LAERMSTIRMKALGKRQLLEEKLND	0.0
20:36718267-36718267 C>T	1.0	4000	MELANOMA	-	-	-	-	RPRD1B	ENST00000373433,p.S324L|NM_021215,p.S324L|uc002xho.4,p.S324L	protein_coding, processed_transcript, nonsense_mediated_decay	uc002xho.4	nonsynonymous SNV	exon7	c.C971T	p.S324L	GLAPLPSAGDLFSTD	GLAPLPSAGDLFLTD	9.0	9.0	-	-	4000_20:36718267-36718267 C>T_GLAPLPSAGDLFLTD	0.0
11:5758263-5758263 G>A	0.0	3903	MELANOMA	-	-	-	-	OR56B1	uc001mbs.1,p.A173T|ENST00000317121,p.A173T|uc009yev.1,p.A173T|uc001mbt.2,p.A173T|NM_001005180,p.A173T	protein_coding	uc009yev.1	nonsynonymous SNV	exon4	c.G517A	p.A173T	NGLFVTPVPVLAAQRDYCSKNEIEH	NGLFVTPVPVLATQRDYCSKNEIEH	1.0	4.0	-	-	3903_11:5758263-5758263 G>A_NGLFVTPVPVLATQRDYCSKNEIEH	0.0
19:19737867-19737867 G>A	1.0	4284	COLORECTAL	-	-	-	-	LPAR2	ENST00000407877,p.A76V|ENST00000542587,p.A76V|NM_004720,p.A76V|uc002nnc.4,p.A76V|uc002nna.4,p.A76V|uc002nnb.4,p.A76V|ENST00000586703,p.A76V	retained_intron, protein_coding, processed_transcript	uc002nnc.4	nonsynonymous SNV	exon5	c.C227T	p.A76V	HQPIYYLLGNLAAADLFAGVAYLFL	HQPIYYLLGNLAVADLFAGVAYLFL	6.0	3.0	-	-	4284_19:19737867-19737867 G>A_HQPIYYLLGNLAVADLFAGVAYLFL	0.0
17:30348680-30348680 T>G	0.0	4245	COLORECTAL	-	-	-	-	LRRC37B	uc031qzt.1,p.L90R|ENST00000327564,p.L199R|ENST00000341671,p.L172R|ENST00000394713,p.L172R|uc002hgu.3,p.L172R|uc010csu.3,p.L172R|uc010wbx.2,p.L90R|ENST00000583342,p.L154R|ENST00000578674,p.L184R|uc031qzs.1,p.L90R|ENST00000543378,p.L90R|ENST00000584368,p.L184R|NM_052888,p.L172R|uc031qzu.1,p.L90R|ENST00000579206,p.L90R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qzu.1	nonsynonymous SNV	exon1	c.T269G	p.L90R	LDRAAGHQADEILVPLDSKVSRPTK	LDRAAGHQADEIRVPLDSKVSRPTK	8.0	2.0	-	-	4245_17:30348680-30348680 T>G_LDRAAGHQADEIRVPLDSKVSRPTK	0.0
1:228433168-228433168 A>G	1.0	4258	ENDOMETRIAL	-	-	-	-	OBSCN	uc009xez.2,p.E1179G|uc001hsn.4,p.E1179G|ENST00000422127,p.E1179G|ENST00000284548,p.E1179G|NM_052843,p.E1179G|ENST00000570156,p.E1271G|NM_001271223,p.E1271G|NM_001098623,p.E1179G|uc001hsq.2,p.E1271G	retained_intron, protein_coding, processed_transcript	uc009xez.2	nonsynonymous SNV	exon12	c.A3536G	p.E1179G	AKEQSVHNEVQAEAGTTAMLSCEVA	AKEQSVHNEVQAGAGTTAMLSCEVA	8.0	9.0	-	-	4258_1:228433168-228433168 A>G_AKEQSVHNEVQAGAGTTAMLSCEVA	0.0
10:71007193-71007193 C>T	1.0	4244	COLORECTAL	-	-	-	-	HKDC1	ENST00000354624,p.A370V|uc010qje.2,p.A233V|uc001jpf.4,p.A370V|NM_025130,p.A370V|ENST00000395086,p.A370V	protein_coding, processed_transcript	uc010qje.2	nonsynonymous SNV	exon6	c.C698T	p.A233V	DLGLEPSEADCIAVQHVCTIVSFRS	DLGLEPSEADCIVVQHVCTIVSFRS	9.0	9.0	-	-	4244_10:71007193-71007193 C>T_DLGLEPSEADCIVVQHVCTIVSFRS	0.0
14:88883081-88883081 C>T	1.0	4345	COLORECTAL	-	-	-	-	SPATA7	uc001xws.3,p.L25F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001xws.3	nonsynonymous SNV	exon4	c.C73T	p.L25F	PRIDADQQRREKLKKELAQCEKEFK	PRIDADQQRREKFKKELAQCEKEFK	6.0	9.0	-	-	4345_14:88883081-88883081 C>T_PRIDADQQRREKFKKELAQCEKEFK	0.0
X:17819221-17819221 G>A	1.0	4252	COLORECTAL	-	-	-	-	RAI2	NM_001172739,p.R304C|NM_001172743,p.R304C|uc022btm.1,p.R304C|ENST00000415486,p.R254C|uc011miy.2,p.R254C|ENST00000545871,p.R304C|ENST00000360011,p.R304C|NM_021785,p.R304C|ENST00000451717,p.R304C|uc022btl.1,p.R304C|ENST00000331511,p.R304C|uc010nfa.3,p.R304C|uc004cyf.3,p.R304C|uc004cyh.4,p.R304C|NM_001172732,p.R254C|uc004cyg.3,p.R304C	protein_coding	uc022btm.1	nonsynonymous SNV	exon1	c.C910T	p.R304C	DILQPKEYFQLSRHTVIKMGSENEA	DILQPKEYFQLSCHTVIKMGSENEA	7.0	10.0	-	-	4252_X:17819221-17819221 G>A_DILQPKEYFQLSCHTVIKMGSENEA	0.0
12:123498588-123498588 T>C	1.0	3713	MELANOMA	-	-	-	-	PITPNM2	ENST00000542210,p.K27R|ENST00000280562,p.K27R|ENST00000542749,p.K27R|NM_001300801,p.K27R|ENST00000392428,p.K27R|uc001uek.1,p.K27R|NM_020845,p.K27R|uc009zxu.1,p.K27R|ENST00000546049,p.K27R|ENST00000320201,p.K27R|uc001uej.1,p.K27R	retained_intron, protein_coding, processed_transcript	uc009zxu.1	nonsynonymous SNV	exon3	c.A80G	p.K27R	EEYRIAQLYMIQKKSRNETYGEGSG	EEYRIAQLYMIQRKSRNETYGEGSG	4.0	8.0	-	-	3713_12:123498588-123498588 T>C_EEYRIAQLYMIQRKSRNETYGEGSG	0.0
5:179397438-179397438 A>C	1.0	4246	COLORECTAL	-	-	-	-	RNF130	uc003mll.1,p.L306R|NM_001280801,p.L306R|ENST00000522208,p.L306R|uc003mlm.1,p.L306R|NM_018434,p.L306R|ENST00000521389,p.L306R|ENST00000261947,p.L306R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003mlm.1	nonsynonymous SNV	exon6	c.T917G	p.L306R	WLSEHCTCPMCKLNILKALGIVPNL	WLSEHCTCPMCKRNILKALGIVPNL	9.0	4.0	-	-	4246_5:179397438-179397438 A>C_WLSEHCTCPMCKRNILKALGIVPNL	0.0
12:53585355-53585355 G>C	0.0	4317	COLORECTAL	-	-	-	-	ITGB7	NM_000889,p.D794E|ENST00000550743,p.D646E|ENST00000267082,p.D794E|ENST00000338737,p.D646E|ENST00000422257,p.D794E|uc009zmv.3,p.D794E|uc001scc.3,p.D794E	retained_intron, protein_coding, nonsense_mediated_decay	uc009zmv.3	nonsynonymous SNV	exon15	c.C2382G	p.D794E	ITTTINPRFQEADSPTL	ITTTINPRFQEAESPTL	4.0	4.0	-	-	4317_12:53585355-53585355 G>C_ITTTINPRFQEAESPTL	0.0
6:144184421-144184421 A>G	1.0	4335	COLORECTAL	-	-	-	-	LTV1	uc003qjs.3,p.K439E|NM_032860,p.K439E|ENST00000367576,p.K439E	protein_coding	uc003qjs.3	nonsynonymous SNV	exon10	c.A1315G	p.K439E	KRARKQAIKEERKERRVEKKANKLA	KRARKQAIKEEREERRVEKKANKLA	8.0	3.0	-	-	4335_6:144184421-144184421 A>G_KRARKQAIKEEREERRVEKKANKLA	0.0
7:103841402-103841402 G>T	1.0	2591	MELANOMA	-	-	-	-	ORC5	NM_002553,p.P57Q|ENST00000297431,p.P57Q|ENST00000447452,p.P57Q|NM_181747,p.P57Q|uc003vcc.3,p.P57Q|uc003vcb.3,p.P57Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vcc.3	nonsynonymous SNV	exon3	c.C170A	p.P57Q	YVTQTLLKTLELPHVFVNCVECFTL	YVTQTLLKTLELQHVFVNCVECFTL	8.0	8.0	-	-	2591_7:103841402-103841402 G>T_YVTQTLLKTLELQHVFVNCVECFTL	0.0
12:130926714-130926714 C>T	0.0	4316	COLORECTAL	-	-	-	-	RIMBP2	NM_015347,p.D378N|ENST00000535703,p.D286N|uc001uim.3,p.D286N|uc001uil.2,p.D378N|ENST00000536002,p.D286N|ENST00000261655,p.D378N	retained_intron, protein_coding, nonsense_mediated_decay	uc001uim.3	nonsynonymous SNV	exon12	c.G856A	p.D286N	ISVQCVTSRGSSDELQCTLLVGKDV	ISVQCVTSRGSSNELQCTLLVGKDV	3.0	10.0	-	-	4316_12:130926714-130926714 C>T_ISVQCVTSRGSSNELQCTLLVGKDV	0.0
6:30609962-30609962 G>A	1.0	4189	MELANOMA	-	-	-	-	ATAT1	ENST00000319027,p.R198K|ENST00000376478,p.R198K|NM_001254952,p.R198K|uc003rdd.3,p.R198K|ENST00000318999,p.R198K|uc011dmm.2,p.R186K|uc003nqs.4,p.R198K	retained_intron, protein_coding, processed_transcript	uc011dmm.2	nonsynonymous SNV	exon8	c.G557A	p.R186K	FEGFFAHQHPPARKLPPKRAEGDIK	FEGFFAHQHPPAKKLPPKRAEGDIK	7.0	4.0	-	-	4189_6:30609962-30609962 G>A_FEGFFAHQHPPAKKLPPKRAEGDIK	0.0
3:98531290-98531290 G>A	0.0	4345	COLORECTAL	-	-	-	-	DCBLD2	ENST00000326857,p.R417C|uc003dte.3,p.R417C|NM_080927,p.R417C|uc003dtd.3,p.R417C|ENST00000326840,p.R417C	retained_intron, protein_coding, processed_transcript	uc003dte.3	nonsynonymous SNV	exon10	c.C1249T	p.R417C	IFQGNKDYHQDVRNNFLPPIIARFI	IFQGNKDYHQDVCNNFLPPIIARFI	5.0	10.0	-	-	4345_3:98531290-98531290 G>A_IFQGNKDYHQDVCNNFLPPIIARFI	0.0
5:140250882-140250882 G>T	0.0	4213	COLORECTAL	-	-	-	-	PCDHA11	NM_031861,p.A732S|uc011dae.2,p.A732S|NM_018902,p.A732S|ENST00000398640,p.A732S|uc003lia.2,p.A732S	protein_coding	uc011dae.2	nonsynonymous SNV	exon1	c.G2194T	p.A732S	LWWSATPTEGACAPGKPTLVCSRAV	LWWSATPTEGACSPGKPTLVCSRAV	2.0	6.0	-	-	4213_5:140250882-140250882 G>T_LWWSATPTEGACSPGKPTLVCSRAV	0.0
1:53099220-53099220 T>C	0.0	4335	COLORECTAL	-	-	-	-	FAM159A	uc001cuf.3,p.F19L|ENST00000517870,p.F19L|NM_001042693,p.F19L	protein_coding, processed_transcript	uc001cuf.3	nonsynonymous SNV	exon1	c.T55C	p.F19L	SYVSAEQEVVRGFSCPRPGGEAAAV	SYVSAEQEVVRGLSCPRPGGEAAAV	5.0	10.0	-	-	4335_1:53099220-53099220 T>C_SYVSAEQEVVRGLSCPRPGGEAAAV	0.0
14:105414683-105414683 G>C	0.0	4186	BREAST	-	-	-	-	AHNAK2	NM_138420,p.Q2369E|uc001ypx.2,p.Q2269E|ENST00000333244,p.Q2369E|uc010axc.1,p.Q2369E	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.C7105G	p.Q2369E	MQGDLKTTDLSVQPPSADLEVQAGQ	MQGDLKTTDLSVEPPSADLEVQAGQ	5.0	4.0	-	-	4186_14:105414683-105414683 G>C_MQGDLKTTDLSVEPPSADLEVQAGQ	0.0
3:16216668-16216668 A>G	0.0	4284	COLORECTAL	-	-	-	-	GALNT15	ENST00000437509,p.R4G|ENST00000339732,p.R4G|uc003car.4,p.R4G|NM_054110,p.R4G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003car.4	nonsynonymous SNV	exon1	c.A10G	p.R4G	MLLRKRYRHRPCRLQF	MLLGKRYRHRPCRLQF	3.0	6.0	-	-	4284_3:16216668-16216668 A>G_MLLGKRYRHRPCRLQF	0.0
1:206634592-206634592 G>T	1.0	4252	COLORECTAL	-	-	-	-	SRGAP2	ENST00000414007,p.A875S	protein_coding, processed_transcript	ENST00000414007	nonsynonymous SNV	exon19	c.G2623T	p.A875S	DPEPAFQRSASTAGDIACAFRPVKS	DPEPAFQRSASTSGDIACAFRPVKS	7.0	9.0	-	-	4252_1:206634592-206634592 G>T_DPEPAFQRSASTSGDIACAFRPVKS	0.0
3:48629387-48629387 G>A	1.0	3713	MELANOMA	-	-	-	-	COL7A1	NM_000094,p.S434F|ENST00000454817,p.S434F|ENST00000328333,p.S434F|uc003ctz.2,p.S434F	retained_intron, protein_coding, processed_transcript	uc003ctz.2	nonsynonymous SNV	exon10	c.C1301T	p.S434F	RPVILGPTSILLSWNLVPEARGYRL	RPVILGPTSILLFWNLVPEARGYRL	4.0	7.0	-	-	3713_3:48629387-48629387 G>A_RPVILGPTSILLFWNLVPEARGYRL	0.0
12:125609519-125609519 G>A	1.0	3713	MELANOMA	-	-	-	-	AACS	uc001uhc.3,p.E420K|ENST00000538851,p.E85K|ENST00000316543,p.E18K|uc001uhd.3,p.E420K|NM_023928,p.E420K|ENST00000441247,p.E239K|ENST00000316519,p.E420K|uc009zyi.3,p.E18K|ENST00000261686,p.E420K	protein_coding, processed_transcript, nonsense_mediated_decay	uc009zyi.3	nonsynonymous SNV	exon5	c.G52A	p.E18K	LSTGSPLKAQSYEYVYRCIKSSILL	LSTGSPLKAQSYKYVYRCIKSSILL	3.0	9.0	-	-	3713_12:125609519-125609519 G>A_LSTGSPLKAQSYKYVYRCIKSSILL	0.0
19:15222529-15222529 G>C	0.0	4335	COLORECTAL	-	-	-	-	SYDE1	uc002nai.1,p.D435H|uc002nah.1,p.D502H|NM_033025,p.D502H|ENST00000600252,p.D159H|ENST00000342784,p.D502H|uc002naj.1,p.D159H|NM_001300910,p.D435H|ENST00000600440,p.D435H	protein_coding	uc002naj.1	nonsynonymous SNV	exon3	c.G475C	p.D159H	PLYKVVLEAMARDPPNRVPPTTEGT	PLYKVVLEAMARHPPNRVPPTTEGT	5.0	4.0	-	-	4335_19:15222529-15222529 G>C_PLYKVVLEAMARHPPNRVPPTTEGT	0.0
10:105793790-105793790 C>T	0.0	3775	CERVICAL	-	-	-	-	COL17A1	ENST00000369733,p.A1275T|NM_000494,p.A1357T|uc001kxr.3,p.A1357T|ENST00000353479,p.A1357T	retained_intron, protein_coding, processed_transcript	uc001kxr.3	nonsynonymous SNV	exon52	c.G4069A	p.A1357T	GGYGAAAEGGMYAGNGGLLGADFAG	GGYGAAAEGGMYTGNGGLLGADFAG	1.0	4.0	-	-	3775_10:105793790-105793790 C>T_GGYGAAAEGGMYTGNGGLLGADFAG	0.0
9:35107394-35107394 G>A	1.0	3919	MELANOMA	-	-	-	-	FAM214B	uc022bgj.1,p.P293L	protein_coding, processed_transcript	uc022bgj.1	nonsynonymous SNV	exon1	c.C878T	p.P293L	KATPFWSHLLPGPKEPVLVSQ	KATPFWSHLLPGLKEPVLVSQ	7.0	10.0	-	-	3919_9:35107394-35107394 G>A_KATPFWSHLLPGLKEPVLVSQ	0.0
4:155411540-155411540 C>T	0.0	4287	COLORECTAL	-	-	-	-	DCHS2	NM_001142552,p.R323H|ENST00000339452,p.R323H|uc011cik.1,p.R323H|ENST00000456341,p.R316H|ENST00000443500,p.R323H|uc003inx.2,p.R323H	protein_coding, processed_transcript	uc011cik.1	nonsynonymous SNV	exon1	c.G968A	p.R323H	PGAEVCRVRATDRDLGPNGFVRYSV	PGAEVCRVRATDHDLGPNGFVRYSV	2.0	9.0	-	-	4287_4:155411540-155411540 C>T_PGAEVCRVRATDHDLGPNGFVRYSV	0.0
1:169824055-169824055 C>T	1.0	4252	COLORECTAL	-	-	-	-	SCYL3	uc001ggs.3,p.V509I|NM_181093,p.V509I|NM_020423,p.V455I|uc001ggt.3,p.V455I|ENST00000367771,p.V455I|ENST00000367770,p.V509I|ENST00000423670,p.V455I|ENST00000367772,p.V509I|uc010plw.2,p.V101I	protein_coding, processed_transcript	uc010plw.2	nonsynonymous SNV	exon7	c.G301A	p.V101I	QPIKFPINGLSDVKNTSEDSENFPS	QPIKFPINGLSDIKNTSEDSENFPS	7.0	8.0	-	-	4252_1:169824055-169824055 C>T_QPIKFPINGLSDIKNTSEDSENFPS	0.0
16:2814041-2814041 C>T	1.0	4158	COLORECTAL	-	-	-	-	SRRM2	uc010bsu.1,p.P1075L|uc002crk.3,p.P1171L|uc002crl.1,p.P1171L|NM_016333,p.P1171L|ENST00000301740,p.P1171L|uc002crj.1,p.P1075L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bsu.1	nonsynonymous SNV	exon10	c.C3224T	p.P1075L	LETAESKEKMALPPQEDATASPPRQ	LETAESKEKMALLPQEDATASPPRQ	10.0	10.0	-	-	4158_16:2814041-2814041 C>T_LETAESKEKMALLPQEDATASPPRQ	0.0
19:41622492-41622492 C>T	0.0	2591	MELANOMA	-	-	-	-	CYP2F1	uc002opu.1,p.P102S|ENST00000331105,p.P102S|NM_000774,p.P102S|ENST00000532164,p.P102S|uc010xvv.1,p.P102S	retained_intron, protein_coding, nonsense_mediated_decay, non_stop_decay	uc010xvv.1	nonsynonymous SNV	exon3	c.C304T	p.P102S	DQGEEFSGRGDYPAFFNFTKGNGIA	DQGEEFSGRGDYSAFFNFTKGNGIA	1.0	9.0	-	-	2591_19:41622492-41622492 C>T_DQGEEFSGRGDYSAFFNFTKGNGIA	0.0
2:172935770-172935770 C>T	1.0	3713	MELANOMA	-	-	-	-	METAP1D	NM_199227,p.P226S|ENST00000315796,p.P226S|uc010zdw.2,p.P108S|uc002uhk.3,p.P226S	protein_coding, processed_transcript	uc010zdw.2	nonsynonymous SNV	exon6	c.C322T	p.P108S	RDEAIAACRAGAPFSVIGNTISHIT	RDEAIAACRAGASFSVIGNTISHIT	8.0	4.0	-	-	3713_2:172935770-172935770 C>T_RDEAIAACRAGASFSVIGNTISHIT	0.0
12:25380276-25380276 T>A	1.0	4126	NSCLC	-	-	ID=COSM1140131,COSM553;OCCURENCE=15(lung),2(thyroid),2(haematopoietic_and_lymphoid_tissue),1(stomach),1(small_intestine),1(breast),4(skin),3(biliary_tract),52(large_intestine),1(kidney),2(pancreas),2(urinary_tract),1(soft_tissue),3(endometrium),1(salivary_gland)	1	KRAS	NM_004985,p.Q61L|NM_033360,p.Q61L|uc001rgp.1,p.Q61L|ENST00000311936,p.Q61L|ENST00000256078,p.Q61L|uc001rgq.1,p.Q61L	protein_coding	uc001rgq.1	nonsynonymous SNV	exon3	c.A182T	p.Q61L	ETCLLDILDTAGQEEYSAMRDQYMR	ETCLLDILDTAGLEEYSAMRDQYMR	7.0	7.0	-	-	4126_12:25380276-25380276 T>A_ETCLLDILDTAGLEEYSAMRDQYMR	0.0
14:105177483-105177483 C>T	1.0	3795	MELANOMA	-	-	-	-	INF2	ENST00000252527,p.S261F|ENST00000330634,p.S793F|ENST00000392634,p.S793F|NM_001031714,p.S793F|uc001ypb.2,p.S793F|uc001ypc.2,p.S793F|NM_022489,p.S793F	retained_intron, protein_coding, nonsense_mediated_decay	uc001ypc.2	nonsynonymous SNV	exon15	c.C2378T	p.S793F	KISTLLKLTETKSQQNRVTLLHHVL	KISTLLKLTETKFQQNRVTLLHHVL	8.0	8.0	-	-	3795_14:105177483-105177483 C>T_KISTLLKLTETKFQQNRVTLLHHVL	0.0
12:80735917-80735917 G>A	0.0	4301	MELANOMA	-	-	-	-	OTOGL	NM_173591,p.R1738K|uc001szd.3,p.R1738K|ENST00000458043,p.R1738K|ENST00000547103,p.R1726K	protein_coding, nonsense_mediated_decay	uc001szd.3	nonsynonymous SNV	exon43	c.G5213A	p.R1738K	HDCSQCIDLLNRRIFIPCHDKVSPE	HDCSQCIDLLNRKIFIPCHDKVSPE	4.0	1.0	-	-	4301_12:80735917-80735917 G>A_HDCSQCIDLLNRKIFIPCHDKVSPE	0.0
8:145660239-145660239 G>A	1.0	3466	MELANOMA	-	-	-	-	TONSL	ENST00000409379,p.P1014S|uc011llg.2,p.P1014S|NM_013432,p.P1014S	retained_intron, protein_coding	uc011llg.2	nonsynonymous SNV	exon20	c.C3040T	p.P1014S	EVLAEVTSWDLPPLTDRYRRACQSL	EVLAEVTSWDLPSLTDRYRRACQSL	3.0	8.0	-	-	3466_8:145660239-145660239 G>A_EVLAEVTSWDLPSLTDRYRRACQSL	0.0
2:39964067-39964067 ->T	1.0	4078	GASTRIC	-	-	-	-	THUMPD2	uc002rru.2,p.K440fs|ENST00000505747,p.K440fs|ENST00000260619,p.K410fs|uc010ynt.1,p.K331fs|NM_025264,p.K440fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ynt.1	frameshift insertion	exon10	c.992dupA	p.K331fs	SKDSHTDEPGIKKCLNPEEKTGAFK	SKDSHTDEPGIKKVLES	8.0	1.0	-	-	4078_2:39964067-39964067 ->T_SKDSHTDEPGIKKVLES	0.0
11:108264079-108264079 T>G	1.0	4284	COLORECTAL	-	-	-	-	C11orf65	ENST00000525729,p.K147T|ENST00000529391,p.K196T|ENST00000533583,p.K178T|NM_152587,p.K196T|uc010rvx.1,p.K147T|ENST00000393084,p.K196T|ENST00000527531,p.K196T|uc001pkh.3,p.K196T	protein_coding, processed_transcript, nonsense_mediated_decay	uc010rvx.1	nonsynonymous SNV	exon5	c.A440C	p.K147T	MRQMYYSGSLEAKSTHHETLGLIHT	MRQMYYSGSLEATSTHHETLGLIHT	4.0	6.0	-	-	4284_11:108264079-108264079 T>G_MRQMYYSGSLEATSTHHETLGLIHT	0.0
9:135976958-135976958 G>A	1.0	3784	MELANOMA	-	-	-	2	RALGDS	uc004ccv.1,p.H629Y	protein_coding, processed_transcript	uc004ccv.1	nonsynonymous SNV	exon11	c.C1885T	p.H629Y	AALQPAGGRLLYHPRQPGRGQWQHV	AALQPAGGRLLYYPRQPGRGQWQHV	8.0	3.0	-	-	3784_9:135976958-135976958 G>A_AALQPAGGRLLYYPRQPGRGQWQHV	0.0
19:22940516-22940516 G>A	1.0	4317	COLORECTAL	-	-	-	-	ZNF99	NM_001080409,p.P732L|uc021urt.1,p.P732L|ENST00000397104,p.P641L|ENST00000596209,p.P732L	protein_coding	uc021urt.1	nonsynonymous SNV	exon4	c.C2195T	p.P732L	LRKHEIIHTGEKPYKCEECGKAFKW	LRKHEIIHTGEKLYKCEECGKAFKW	5.0	8.0	-	-	4317_19:22940516-22940516 G>A_LRKHEIIHTGEKLYKCEECGKAFKW	0.0
1:39976857-39976857 C>T	0.0	4252	COLORECTAL	-	-	-	-	BMP8A	uc001cdi.3,p.R116C|ENST00000331593,p.R116C|NM_181809,p.R116C	protein_coding	uc001cdi.3	nonsynonymous SNV	exon2	c.C346T	p.R116C	LVMSFVNMVERDRALGHQEPHWKEF	LVMSFVNMVERDCALGHQEPHWKEF	4.0	10.0	-	-	4252_1:39976857-39976857 C>T_LVMSFVNMVERDCALGHQEPHWKEF	0.0
5:145317829-145317829 C>T	1.0	3466	MELANOMA	-	-	-	-	SH3RF2	NM_152550,p.P113L|uc011dbl.1,p.P113L|ENST00000359120,p.P113L|uc003lnt.3,p.P113L|ENST00000511217,p.P113L	retained_intron, protein_coding, processed_transcript	uc011dbl.1	nonsynonymous SNV	exon1	c.C338T	p.P113L	KSRTNPRRLQASPFRLVPNVRIHMD	KSRTNPRRLQASLFRLVPNVRIHMD	3.0	9.0	-	-	3466_5:145317829-145317829 C>T_KSRTNPRRLQASLFRLVPNVRIHMD	0.0
20:33519193-33519193 C>T	1.0	3795	MELANOMA	-	-	-	-	GSS	uc010gez.1,p.E83K|ENST00000541098,p.E225K|ENST00000451957,p.E242K|uc010zuo.2,p.E242K|ENST00000216951,p.E353K|uc002xbg.3,p.E353K|uc010zup.2,p.E284K|uc010zun.2,p.E225K|NM_000178,p.E353K	protein_coding	uc010zup.2	nonsynonymous SNV	exon11	c.G850A	p.E284K	LDVGEEGDQAIAEALAAPSRFVLKP	LDVGEEGDQAIAKALAAPSRFVLKP	8.0	5.0	-	-	3795_20:33519193-33519193 C>T_LDVGEEGDQAIAKALAAPSRFVLKP	0.0
6:35203231-35203231 C>T	1.0	4298	COLORECTAL	-	-	-	-	SCUBE3	uc003okh.1,p.R112W|ENST00000394681,p.R241W	protein_coding	uc003okh.1	nonsynonymous SNV	exon6	c.C334T	p.R112W	LHTDGKTCIGERRLEQHIPTQAVSN	LHTDGKTCIGERWLEQHIPTQAVSN	4.0	10.0	-	-	4298_6:35203231-35203231 C>T_LHTDGKTCIGERWLEQHIPTQAVSN	0.0
16:70841528-70841528 C>G	0.0	3775	CERVICAL	-	-	-	-	HYDIN	uc031qwy.1,p.E5107D|NM_001270974,p.E5107D|ENST00000393567,p.E5107D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qwy.1	nonsynonymous SNV	exon86	c.G15321C	p.E5107D	KLTVSCPPGEGSETGVKWVYYLKGI	KLTVSCPPGEGSDTGVKWVYYLKGI	2.0	6.0	-	-	3775_16:70841528-70841528 C>G_KLTVSCPPGEGSDTGVKWVYYLKGI	0.0
15:65703370-65703370 C>T	0.0	4259	COLORECTAL	0.0014	-	-	-	IGDCC4	uc002aou.1,p.V137I|NM_020962,p.V137I|ENST00000352385,p.V137I	retained_intron, protein_coding, processed_transcript	uc002aou.1	nonsynonymous SNV	exon2	c.G409A	p.V137I	GPLGVLASQTAVVKLATLADFSLHP	GPLGVLASQTAVIKLATLADFSLHP	5.0	4.0	-	-	4259_15:65703370-65703370 C>T_GPLGVLASQTAVIKLATLADFSLHP	0.0
22:42385598-42385598 G>T	1.0	2591	MELANOMA	-	-	-	-	SEPT3	ENST00000396426,p.M193I|ENST00000291236,p.M129I|ENST00000396425,p.M193I|uc011apj.2,p.M129I|uc003bbr.4,p.M193I|ENST00000406029,p.M129I|NM_019106,p.M193I|NM_145733,p.M193I|uc003bbs.4,p.M193I	retained_intron, protein_coding, nonsense_mediated_decay	uc011apj.2	nonsynonymous SNV	exon5	c.G387T	p.M129I	TGHSLRPLDLEFMKHLSKVVNIIPV	TGHSLRPLDLEFIKHLSKVVNIIPV	8.0	9.0	-	-	2591_22:42385598-42385598 G>T_TGHSLRPLDLEFIKHLSKVVNIIPV	0.0
2:187540581-187540581 C>T	1.0	3466	MELANOMA	-	-	-	2	ITGAV	ENST00000374907,p.S916L|uc002upq.4,p.S952L|uc010zfv.3,p.S906L|uc010frs.4,p.S916L|ENST00000433736,p.S906L|NM_001144999,p.S906L|ENST00000261023,p.S952L|NM_002210,p.S952L|NM_001145000,p.S916L	retained_intron, protein_coding, processed_transcript	uc010zfv.3	nonsynonymous SNV	exon28	c.C2717T	p.S906L	NKENQNHSYSLKSSASFNVIEFPYK	NKENQNHSYSLKLSASFNVIEFPYK	10.0	7.0	-	-	3466_2:187540581-187540581 C>T_NKENQNHSYSLKLSASFNVIEFPYK	0.0
11:35454061-35454061 G>A	0.0	4160	COLORECTAL	-	-	ID=COSM926686;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(endometrium)	-	PAMR1	ENST00000532848,p.A629V|ENST00000278360,p.A686V|uc010rew.2,p.A558V|NM_001282676,p.A558V|ENST00000378878,p.A558V|NM_015430,p.A686V|NM_001282675,p.A629V|NM_001001991,p.A669V|uc001mwf.3,p.A686V|ENST00000378880,p.A669V|uc010rex.2,p.A629V|ENST00000527605,p.A646V|uc001mwg.3,p.A669V	retained_intron, protein_coding, processed_transcript	uc010rex.2	nonsynonymous SNV	exon13	c.C1886T	p.A629V	PSDICTAETGGIAAVSFPGRASPEP	PSDICTAETGGIVAVSFPGRASPEP	4.0	3.0	-	-	4160_11:35454061-35454061 G>A_PSDICTAETGGIVAVSFPGRASPEP	0.0
3:36931409-36931409 T>C	1.0	4320	COLORECTAL	-	-	-	-	TRANK1	NM_014831,p.E229G|uc003cgj.3,p.E229G|ENST00000429976,p.E229G	protein_coding, processed_transcript	uc003cgj.3	nonsynonymous SNV	exon7	c.A686G	p.E229G	NHLFRWLMDHKPEWKGRINQKDGDG	NHLFRWLMDHKPGWKGRINQKDGDG	7.0	2.0	-	-	4320_3:36931409-36931409 T>C_NHLFRWLMDHKPGWKGRINQKDGDG	0.0
14:89038472-89038472 G>C	1.0	4126	NSCLC	-	-	-	-	ZC3H14	uc010twe.2,p.A112P|ENST00000359301,p.A78P|ENST00000393514,p.A112P|ENST00000555120,p.A78P|uc001xwx.3,p.A112P|ENST00000555799,p.A78P|NM_024824,p.A112P|uc010twd.2,p.A112P|NM_001160103,p.A112P|ENST00000302216,p.A112P|NM_001160104,p.A112P|NM_207660,p.A112P|ENST00000251038,p.A112P|uc001xww.3,p.A112P|uc001xwy.3,p.A78P|ENST00000555755,p.A112P|NM_207661,p.A78P|ENST00000557693,p.A78P|ENST00000336693,p.A78P|ENST00000556158,p.A99P|ENST00000556945,p.A112P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010twe.2	nonsynonymous SNV	exon5	c.G334C	p.A112P	SNFSRGDERRHEAAVPPLAIPSARP	SNFSRGDERRHEPAVPPLAIPSARP	10.0	7.0	-	-	4126_14:89038472-89038472 G>C_SNFSRGDERRHEPAVPPLAIPSARP	0.0
5:59893632-59893632 G>A	0.0	4238	COLORECTAL	-	-	-	-	DEPDC1B	uc011cqm.2,p.A451V|ENST00000265036,p.A513V|ENST00000545085,p.A424V|uc011cqn.2,p.A424V|uc003jsh.3,p.A513V|ENST00000453022,p.A451V|NM_018369,p.A513V|NM_001145208,p.A451V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cqn.2	nonsynonymous SNV	exon11	c.C1271T	p.A424V	EKPKPKPQLLMWALKKPFQPFQRTR	EKPKPKPQLLMWVLKKPFQPFQRTR	5.0	4.0	-	-	4238_5:59893632-59893632 G>A_EKPKPKPQLLMWVLKKPFQPFQRTR	0.0
16:29917114-29917114 C>T	1.0	2556	MELANOMA	-	-	-	-	ASPHD1	NM_181718,p.P357S|ENST00000566693,p.P357S|ENST00000563177,p.P76S|uc002dut.3,p.P357S|ENST00000414952,p.P357S|ENST00000483405,p.P76S|ENST00000308748,p.P357S	protein_coding, nonsense_mediated_decay	uc002dut.3	nonsynonymous SNV	exon3	c.C1069T	p.P357S	DSFLHTVAHNGSPEDGPRVVFIVDL	DSFLHTVAHNGSSEDGPRVVFIVDL	5.0	3.0	-	-	2556_16:29917114-29917114 C>T_DSFLHTVAHNGSSEDGPRVVFIVDL	0.0
12:123970291-123970291 T>A	1.0	4287	COLORECTAL	-	-	-	-	RILPL1	uc001ufe.2,p.D288V|NM_178314,p.D288V|uc001ufd.2,p.D137V|ENST00000340724,p.D136V|uc010tas.1,p.D288V|ENST00000376874,p.D288V	protein_coding	uc010tas.1	nonsynonymous SNV	exon5	c.A863T	p.D288V	ISDAEKVAMDLKDPNRPRFTLQELR	ISDAEKVAMDLKVPNRPRFTLQELR	5.0	3.0	-	-	4287_12:123970291-123970291 T>A_ISDAEKVAMDLKVPNRPRFTLQELR	0.0
17:7577539-7577539 G>A	1.0	4287	COLORECTAL	-	-	ID=COSM3388183,COSM120007,COSM120006,COSM10656,COSM120005,COSM1640831;OCCURENCE=61(breast),26(skin),9(biliary_tract),144(large_intestine),4(prostate),4(liver),2(kidney),11(pancreas),21(urinary_tract),31(ovary),4(soft_tissue),20(endometrium),20(lung),1(penis),4(thyroid),27(haematopoietic_and_lymphoid_tissue),1(pleura),1(cervix),28(stomach),33(central_nervous_system),45(oesophagus),1(vulva),1(bone),21(upper_aerodigestive_tract),1(NS)	1	TP53	NM_001126118,p.R209W|ENST00000445888,p.R248W|ENST00000420246,p.R248W|NM_001276695,p.R209W|NM_001126112,p.R248W|ENST00000413465,p.R248W|NM_001276761,p.R209W|uc002gih.3,p.R248W|uc010cng.2,p.R89W|NM_001276699,p.R89W|ENST00000509690,p.R116W|NM_001276760,p.R209W|NM_001276696,p.R209W|NM_001276698,p.R89W|ENST00000455263,p.R248W|ENST00000269305,p.R248W|ENST00000359597,p.R248W|NM_001126113,p.R248W|NM_000546,p.R248W|uc010cnf.2,p.R89W|uc031qyq.1,p.R209W|NM_001126114,p.R248W|NM_001126116,p.R116W|NM_001126115,p.R116W|uc002gij.3,p.R209W|NM_001126117,p.R116W|uc002gii.2,p.R89W|uc002gin.3,p.R155W|uc002gig.1,p.R248W|uc002gio.3,p.R116W|NM_001276697,p.R89W	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon6	c.C625T	p.R209W	YMCNSSCMGGMNRRPILTIITLEDS	YMCNSSCMGGMNWRPILTIITLEDS	10.0	10.0	-	-	4287_17:7577539-7577539 G>A_YMCNSSCMGGMNWRPILTIITLEDS	0.0
3:75787470-75787470 T>G	0.0	4345	COLORECTAL	-	-	-	-	ZNF717	uc011bgi.2,p.K435T|NM_001290208,p.K435T|NM_001290209,p.K385T|ENST00000478296,p.K385T|ENST00000400845,p.K428T|NM_001128223,p.K435T|ENST00000422325,p.K435T	protein_coding, processed_transcript	uc011bgi.2	nonsynonymous SNV	exon5	c.A1304C	p.K435T	YACDHCEEAFSHKSRLTVHQRTHTG	YACDHCEEAFSHTSRLTVHQRTHTG	4.0	8.0	-	-	4345_3:75787470-75787470 T>G_YACDHCEEAFSHTSRLTVHQRTHTG	0.0
2:55756046-55756046 T>G	1.0	4071	COLORECTAL	-	-	-	-	CFAP36	ENST00000339012,p.D130E|uc002ryx.2,p.D130E|uc002ryy.2,p.D105E|ENST00000349456,p.D105E|ENST00000407816,p.D105E|ENST00000406691,p.D105E|NM_001282761,p.D130E|ENST00000403007,p.D105E|NM_080667,p.D105E	retained_intron, protein_coding, processed_transcript	uc002ryy.2	nonsynonymous SNV	exon4	c.T315G	p.D105E	SQAILQPVLAAEDFTIFKAMMVQKN	SQAILQPVLAAEEFTIFKAMMVQKN	6.0	5.0	-	-	4071_2:55756046-55756046 T>G_SQAILQPVLAAEEFTIFKAMMVQKN	0.0
21:34399460-34399460 A>G	1.0	3903	MELANOMA	-	-	-	1	OLIG2	uc002yqx.2,p.D97G|NM_005806,p.D97G|ENST00000382357,p.D97G|ENST00000333337,p.D97G|uc021wil.1,p.D97G	protein_coding	uc021wil.1	nonsynonymous SNV	exon1	c.A290G	p.D97G	STSSAAASSTKKDKKQMTEPELQQL	STSSAAASSTKKGKKQMTEPELQQL	8.0	3.0	-	-	3903_21:34399460-34399460 A>G_STSSAAASSTKKGKKQMTEPELQQL	0.0
7:883269-883269 C>T	1.0	4000	MELANOMA	-	-	-	-	SUN1	uc010ksa.1,p.P278L|uc021zyl.1,p.P257L|ENST00000403868,p.P257L|ENST00000457378,p.P278L|NM_001171945,p.P278L|NM_001171946,p.P257L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zyl.1	nonsynonymous SNV	exon6	c.C770T	p.P257L	CLHYLSWRLKIIP	CLHYLSWRLKIIL	10.0	6.0	-	-	4000_7:883269-883269 C>T_CLHYLSWRLKIIL	0.0
9:136672418-136672418 T>G	1.0	4320	COLORECTAL	-	-	-	-	VAV2	uc004cer.3,p.S228R|uc004ces.3,p.S233R|ENST00000406606,p.S228R|ENST00000371850,p.S233R|NM_003371,p.S228R|NM_001134398,p.S233R|ENST00000371851,p.S228R	protein_coding, processed_transcript	uc004ces.3	nonsynonymous SNV	exon8	c.A697C	p.S233R	EKNYMSPLRLVLSPADMAAVFINLE	EKNYMSPLRLVLRPADMAAVFINLE	8.0	8.0	-	-	4320_9:136672418-136672418 T>G_EKNYMSPLRLVLRPADMAAVFINLE	0.0
8:61761647-61761647 G>A	1.0	3775	CERVICAL	-	-	-	-	CHD7	uc003xue.3,p.E1780K|ENST00000423902,p.E1780K|NM_017780,p.E1780K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xue.3	nonsynonymous SNV	exon25	c.G5338A	p.E1780K	EADVWIPEPFHAEVPADWWDKEADK	EADVWIPEPFHAKVPADWWDKEADK	5.0	8.0	-	-	3775_8:61761647-61761647 G>A_EADVWIPEPFHAKVPADWWDKEADK	0.0
9:118949469-118949469 G>A	0.0	3998	MELANOMA	-	-	-	-	PAPPA	ENST00000328252,p.R151Q|NM_002581,p.R151Q|uc004bjn.3,p.R151Q	protein_coding, processed_transcript	uc004bjn.3	nonsynonymous SNV	exon2	c.G452A	p.R151Q	GLYDKCSYISRDRGWVVGIHTISDQ	GLYDKCSYISRDQGWVVGIHTISDQ	3.0	9.0	-	-	3998_9:118949469-118949469 G>A_GLYDKCSYISRDQGWVVGIHTISDQ	0.0
20:23066220-23066220 G>A	0.0	2591	MELANOMA	-	-	ID=COSM1721668;OCCURENCE=2(NS)	-	CD93	NM_012072,p.P204S|uc002wsv.3,p.P204S|ENST00000246006,p.P204S	protein_coding	uc002wsv.3	nonsynonymous SNV	exon1	c.C610T	p.P204S	ALGGPGQVTYTTPFQTTSSSLEAVP	ALGGPGQVTYTTSFQTTSSSLEAVP	1.0	7.0	-	-	2591_20:23066220-23066220 G>A_ALGGPGQVTYTTSFQTTSSSLEAVP	0.0
6:13977957-13977957 T>G	0.0	4186	BREAST	-	-	-	-	RNF182	ENST00000544682,p.L203V|uc003nbe.3,p.L203V|NM_152737,p.L203V|NM_001165033,p.L203V|ENST00000488300,p.L203V|NM_001165032,p.L203V|uc003nbf.3,p.L203V|ENST00000537388,p.L203V|ENST00000537663,p.L203V|uc021ylw.1,p.L203V|uc003nbg.3,p.L203V|uc021ylx.1,p.L203V|uc021yly.1,p.L203V|NM_001165034,p.L203V	protein_coding	uc021yly.1	nonsynonymous SNV	exon1	c.T607G	p.L203V	LLYFSSLPLGIYLLVSKKVTLGVVF	LLYFSSLPLGIYVLVSKKVTLGVVF	1.0	5.0	-	-	4186_6:13977957-13977957 T>G_LLYFSSLPLGIYVLVSKKVTLGVVF	0.0
19:14164439-14164439 C>T	0.0	4235	COLORECTAL	-	-	-	-	PALM3	NM_001145028,p.C667Y|uc010xnk.1,p.C667Y|ENST00000340790,p.C667Y	retained_intron, protein_coding	uc010xnk.1	nonsynonymous SNV	exon6	c.G2000A	p.C667Y	EGEEASGPKQKTCQCCAVM	EGEEASGPKQKTYQCCAVM	4.0	4.0	-	-	4235_19:14164439-14164439 C>T_EGEEASGPKQKTYQCCAVM	0.0
6:42713017-42713017 A>-	1.0	4326	BREAST	-	-	-	-	TBCC	ENST00000244625,p.S265fs|NM_003192,p.S265fs|uc003osl.3,p.S265fs|ENST00000372876,p.S265fs	protein_coding, processed_transcript	uc003osl.3	frameshift deletion	exon1	c.795delT	p.S265fs	VLAVACQQLRIHSTKDTRIFLQVTSR	VLAVACQQLRIHRRKTPASSCR	6.0	9.0	-	-	4326_6:42713017-42713017 A>-_VLAVACQQLRIHRRKTPASSCR	0.0
9:136338623-136338623 G>A	1.0	3466	MELANOMA	-	-	-	-	SLC2A6	uc004ceg.3,p.S356F|uc004cee.3,p.S379F|ENST00000371899,p.S379F|NM_017585,p.S379F	protein_coding, processed_transcript	uc004ceg.3	nonsynonymous SNV	exon8	c.C1067T	p.S356F	LSPNSTAGLESESWGDLAQPLAAPA	LSPNSTAGLESEFWGDLAQPLAAPA	4.0	9.0	-	-	3466_9:136338623-136338623 G>A_LSPNSTAGLESEFWGDLAQPLAAPA	0.0
2:74692302-74692302 C>T	1.0	3879	MELANOMA	-	-	-	-	MOGS	ENST00000409065,p.G25R|NM_006302,p.G25R|ENST00000535045,p.G25R|uc010ffj.3,p.G25R|uc010yru.1,p.G25R|ENST00000233616,p.G25R	retained_intron, protein_coding, processed_transcript	uc010yru.1	nonsynonymous SNV	exon1	c.G73A	p.G25R	AEGVRTAERAARGGPGRRDGRGGGP	AEGVRTAERAARRGPGRRDGRGGGP	7.0	9.0	-	-	3879_2:74692302-74692302 C>T_AEGVRTAERAARRGPGRRDGRGGGP	0.0
20:20621483-20621483 G>C	0.0	3775	CERVICAL	-	-	-	-	RALGAPA2	ENST00000438161,p.Q138E|uc002wrz.3,p.Q138E|ENST00000202677,p.Q138E|NM_020343,p.Q138E	protein_coding, processed_transcript	uc002wrz.3	nonsynonymous SNV	exon6	c.C412G	p.Q138E	RCEGIRLFLLWLQALQTNCAEEQVL	RCEGIRLFLLWLEALQTNCAEEQVL	7.0	5.0	-	-	3775_20:20621483-20621483 G>C_RCEGIRLFLLWLEALQTNCAEEQVL	0.0
4:100844301-100844301 G>A	1.0	4134	NSCLC	-	-	-	-	DNAJB14	uc003hvl.4,p.T116M|uc010ili.4,p.T49M|NM_001278310,p.T49M|uc003hvk.4,p.T31M|NM_001031723,p.T116M|ENST00000442697,p.T116M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ili.4	nonsynonymous SNV	exon2	c.C146T	p.T49M	NKCKNYYEVLGVTKDAGDEDLKKAY	NKCKNYYEVLGVMKDAGDEDLKKAY	7.0	5.0	-	-	4134_4:100844301-100844301 G>A_NKCKNYYEVLGVMKDAGDEDLKKAY	0.0
7:121741426-121741426 T>C	0.0	4081	COLORECTAL	-	-	-	-	AASS	uc003vka.3,p.R469G|ENST00000393376,p.R469G|ENST00000431170,p.R469G|ENST00000358954,p.R469G|NM_005763,p.R469G|ENST00000417368,p.R469G|uc003vkb.3,p.R469G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vkb.3	nonsynonymous SNV	exon13	c.A1405G	p.R469G	DKYKYIQTLRESRERAQSLSMGTRR	DKYKYIQTLRESGERAQSLSMGTRR	3.0	8.0	-	-	4081_7:121741426-121741426 T>C_DKYKYIQTLRESGERAQSLSMGTRR	0.0
10:50028330-50028330 G>A	1.0	4284	COLORECTAL	-	-	-	-	WDFY4	uc001jhb.1,p.E381K|uc001jha.4,p.E1853K|ENST00000325239,p.E1853K|NM_020945,p.E1853K	protein_coding, processed_transcript	uc001jhb.1	nonsynonymous SNV	exon10	c.G1141A	p.E381K	STRNTSSPEAAAEGDSTVEGLQAPT	STRNTSSPEAAAKGDSTVEGLQAPT	6.0	8.0	-	-	4284_10:50028330-50028330 G>A_STRNTSSPEAAAKGDSTVEGLQAPT	0.0
3:51315142-51315142 C>T	0.0	4213	COLORECTAL	-	-	ID=COSM272611;OCCURENCE=1(large_intestine)	-	DOCK3	NM_004947,p.A927V|uc011bds.2,p.A927V|ENST00000266037,p.A927V	protein_coding	uc011bds.2	nonsynonymous SNV	exon26	c.C2780T	p.A927V	LLTIMSKSHAQEAVRGQRCPQCTAE	LLTIMSKSHAQEVVRGQRCPQCTAE	4.0	8.0	-	-	4213_3:51315142-51315142 C>T_LLTIMSKSHAQEVVRGQRCPQCTAE	0.0
13:84454380-84454380 G>T	0.0	4287	COLORECTAL	-	-	-	-	SLITRK1	uc001vlk.3,p.N421K|NM_001281503,p.N421K|ENST00000377084,p.N421K|NM_052910,p.N421K	protein_coding	uc001vlk.3	nonsynonymous SNV	exon1	c.C1263A	p.N421K	NNIATVENNTFKNLLDLRWLYMDSN	NNIATVENNTFKKLLDLRWLYMDSN	1.0	8.0	-	-	4287_13:84454380-84454380 G>T_NNIATVENNTFKKLLDLRWLYMDSN	0.0
19:7682213-7682213 G>A	0.0	3903	MELANOMA	-	-	-	-	CAMSAP3	uc002mgv.4,p.A1072T|NM_020902,p.A1072T|NM_001080429,p.A1099T|uc002mgu.4,p.A1099T|uc002mgw.3,p.A202T|ENST00000446248,p.A1099T|ENST00000160298,p.A1072T	retained_intron, protein_coding	uc002mgw.3	nonsynonymous SNV	exon4	c.G604A	p.A202T	HNNLGVKRPTSRAPSPSGLMSPSRL	HNNLGVKRPTSRTPSPSGLMSPSRL	2.0	9.0	-	-	3903_19:7682213-7682213 G>A_HNNLGVKRPTSRTPSPSGLMSPSRL	0.0
1:158632503-158632503 G>A	0.0	2591	MELANOMA	-	-	-	-	SPTA1	ENST00000368147,p.S818F|uc001fst.1,p.S818F|NM_003126,p.S818F|ENST00000368148,p.S818F	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon17	c.C2453T	p.S818F	EAWIQETEPSATSTYLGKDLIASKK	EAWIQETEPSATFTYLGKDLIASKK	1.0	7.0	-	-	2591_1:158632503-158632503 G>A_EAWIQETEPSATFTYLGKDLIASKK	0.0
1:36769574-36769574 G>A	1.0	3713	MELANOMA	-	-	-	2	THRAP3	ENST00000354618,p.E942K|NM_005119,p.E942K|ENST00000469141,p.E942K|uc001cae.4,p.E942K|uc001caf.4,p.E942K	protein_coding, processed_transcript	uc001caf.4	nonsynonymous SNV	exon13	c.G2824A	p.E942K	EEGEIEDDESGTENREEKDNIQPTT	EEGEIEDDESGTKNREEKDNIQPTT	9.0	10.0	-	-	3713_1:36769574-36769574 G>A_EEGEIEDDESGTKNREEKDNIQPTT	0.0
11:93912839-93912839 C>T	1.0	3678	MELANOMA	-	-	-	-	PANX1	ENST00000436171,p.S206F|NM_015368,p.S206F|uc001peq.3,p.S206F|uc001per.3,p.S206F|ENST00000227638,p.S206F	protein_coding	uc001per.3	nonsynonymous SNV	exon4	c.C617T	p.S206F	PIVEQYLKTKKNSNNLIIKYISCRL	PIVEQYLKTKKNFNNLIIKYISCRL	7.0	1.0	-	-	3678_11:93912839-93912839 C>T_PIVEQYLKTKKNFNNLIIKYISCRL	0.0
19:21300382-21300382 A>G	1.0	4326	BREAST	-	-	-	-	ZNF714	ENST00000596143,p.I304M|uc002npl.3,p.I150M|ENST00000600435,p.I304M	protein_coding, processed_transcript, nonsense_mediated_decay	uc002npl.3	nonsynonymous SNV	exon5	c.A450G	p.I150M	AFNRFSYLTKHKIIHSGEKSYKCEQ	AFNRFSYLTKHKMIHSGEKSYKCEQ	10.0	9.0	-	-	4326_19:21300382-21300382 A>G_AFNRFSYLTKHKMIHSGEKSYKCEQ	0.0
14:103593551-103593551 G>A	1.0	4240	BREAST	-	-	-	-	TNFAIP2	ENST00000333007,p.E149K|NM_006291,p.E149K|ENST00000560869,p.E149K|uc001ymm.1,p.E149K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ymm.1	nonsynonymous SNV	exon2	c.G445A	p.E149K	LGVLRRPLEAPPERLRQALAVVAEQ	LGVLRRPLEAPPKRLRQALAVVAEQ	9.0	7.0	-	-	4240_14:103593551-103593551 G>A_LGVLRRPLEAPPKRLRQALAVVAEQ	0.0
6:31743841-31743841 G>C	1.0	4326	BREAST	-	-	-	-	VWA7	NM_025258,p.A138G|uc011dog.2,p.A138G|ENST00000375686,p.A138G|ENST00000375688,p.A138G|ENST00000447450,p.A138G	retained_intron, protein_coding, processed_transcript	uc011dog.2	nonsynonymous SNV	exon3	c.C413G	p.A138G	LHFDAERLGQGRARLVGALRETVVA	LHFDAERLGQGRGRLVGALRETVVA	4.0	7.0	-	-	4326_6:31743841-31743841 G>C_LHFDAERLGQGRGRLVGALRETVVA	0.0
15:65680858-65680858 G>A	1.0	4196	COLORECTAL	-	-	ID=COSM3377721;OCCURENCE=1(pancreas)	-	IGDCC4	uc002aou.1,p.A925V|uc002aot.1,p.A513V|NM_020962,p.A925V|ENST00000352385,p.A925V	retained_intron, protein_coding, processed_transcript	uc002aou.1	nonsynonymous SNV	exon16	c.C2774T	p.A925V	LESDTRYFFKMGARTEVGPGPFSRL	LESDTRYFFKMGVRTEVGPGPFSRL	5.0	8.0	-	-	4196_15:65680858-65680858 G>A_LESDTRYFFKMGVRTEVGPGPFSRL	0.0
19:56703232-56703232 A>C	0.0	4213	COLORECTAL	-	-	-	-	ZSCAN5B	uc010ygh.2,p.L192R|ENST00000586855,p.L192R|NM_001080456,p.L192R|ENST00000358992,p.L192R	protein_coding	uc010ygh.2	nonsynonymous SNV	exon2	c.T575G	p.L192R	RREQQILPRVAALSRRQGEDFLLHK	RREQQILPRVAARSRRQGEDFLLHK	3.0	5.0	-	-	4213_19:56703232-56703232 A>C_RREQQILPRVAARSRRQGEDFLLHK	0.0
11:31822380-31822380 G>A	0.0	4298	COLORECTAL	-	-	-	-	PAX6	ENST00000379111,p.R128C|ENST00000379129,p.R142C|ENST00000379132,p.R128C|NM_001127612,p.R128C|NM_001258465,p.R128C|ENST00000241001,p.R128C|uc009yjr.3,p.R128C|uc021qfl.1,p.R142C|ENST00000419022,p.R142C|NM_001258463,p.R142C|NM_001258464,p.R128C|ENST00000379123,p.R128C|NM_001604,p.R142C|NM_000280,p.R128C|uc021qfn.1,p.R128C|uc021qfm.1,p.R142C|uc001mtf.5,p.R128C|uc001mtg.5,p.R142C|ENST00000379115,p.R142C|ENST00000379109,p.R128C|ENST00000379107,p.R142C|uc001mte.5,p.R128C|NM_001258462,p.R142C|uc001mtd.4,p.R128C|uc001mth.5,p.R128C	retained_intron, protein_coding, processed_transcript	uc021qfn.1	nonsynonymous SNV	exon4	c.C382T	p.R128C	NIPSVSSINRVLRNLASEKQQMGAD	NIPSVSSINRVLCNLASEKQQMGAD	3.0	5.0	-	-	4298_11:31822380-31822380 G>A_NIPSVSSINRVLCNLASEKQQMGAD	0.0
2:168100576-168100576 G>T	0.0	4329	COLORECTAL	-	-	-	-	XIRP2	uc010fpq.3,p.D670Y|ENST00000409195,p.D892Y|uc002udy.3,p.D717Y|NM_001199144,p.D670Y|NM_152381,p.D892Y|ENST00000409273,p.D670Y|ENST00000295237,p.D892Y|uc002udx.3,p.D892Y	protein_coding	uc010fpq.3	nonsynonymous SNV	exon7	c.G2008T	p.D670Y	ETLPIEALKDSPDIGKLQKITASEE	ETLPIEALKDSPYIGKLQKITASEE	1.0	6.0	-	-	4329_2:168100576-168100576 G>T_ETLPIEALKDSPYIGKLQKITASEE	0.0
10:53458226-53458226 G>A	1.0	2369	MELANOMA	-	-	-	-	CSTF2T	ENST00000331173,p.P362S|NM_015235,p.P362S|uc001jjp.3,p.P362S	protein_coding	uc001jjp.3	nonsynonymous SNV	exon1	c.C1084T	p.P362S	EPRGYLGPPHQGPPMHHASGHDTRG	EPRGYLGPPHQGSPMHHASGHDTRG	8.0	10.0	-	-	2369_10:53458226-53458226 G>A_EPRGYLGPPHQGSPMHHASGHDTRG	0.0
12:55759357-55759357 T>A	0.0	4346	COLORECTAL	-	-	-	-	OR6C75	NM_001005497,p.F155I|ENST00000343399,p.F155I|uc010spk.2,p.F155I	protein_coding	uc010spk.2	nonsynonymous SNV	exon1	c.T463A	p.F155I	VFSSWLAGFLIIFPPVMLLLQLDFC	VFSSWLAGFLIIIPPVMLLLQLDFC	1.0	3.0	-	-	4346_12:55759357-55759357 T>A_VFSSWLAGFLIIIPPVMLLLQLDFC	0.0
12:94543406-94543406 T>A	1.0	4317	COLORECTAL	-	-	-	-	PLXNC1	uc001tdc.3,p.L220Q|NM_005761,p.L220Q|ENST00000258526,p.L220Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001tdc.3	nonsynonymous SNV	exon1	c.T659A	p.L220Q	KDTEGRSLATQELGRLKLCEGAGSL	KDTEGRSLATQEQGRLKLCEGAGSL	5.0	10.0	-	-	4317_12:94543406-94543406 T>A_KDTEGRSLATQEQGRLKLCEGAGSL	0.0
2:27900193-27900193 T>C	1.0	4180	BREAST	-	-	-	-	SLC4A1AP	ENST00000326019,p.L513P|NM_018158,p.L513P|uc002rlk.4,p.L513P	retained_intron, protein_coding, nonsense_mediated_decay	uc002rlk.4	nonsynonymous SNV	exon7	c.T1538C	p.L513P	SLVAKLNDAERELSEISERLKASSQ	SLVAKLNDAEREPSEISERLKASSQ	9.0	7.0	-	-	4180_2:27900193-27900193 T>C_SLVAKLNDAEREPSEISERLKASSQ	0.0
13:32760504-32760504 C>T	0.0	3903	MELANOMA	-	-	ID=COSM230273;OCCURENCE=1(NS),1(large_intestine)	-	FRY	uc001utx.3,p.R1143C|NM_023037,p.R1143C|ENST00000380250,p.R1143C	protein_coding, processed_transcript, nonsense_mediated_decay	uc001utx.3	nonsynonymous SNV	exon27	c.C3427T	p.R1143C	AGPFSIMFTPLDRYSDRNHQITRYQ	AGPFSIMFTPLDCYSDRNHQITRYQ	4.0	6.0	-	-	3903_13:32760504-32760504 C>T_AGPFSIMFTPLDCYSDRNHQITRYQ	0.0
4:123317478-123317478 C>T	0.0	3795	MELANOMA	-	-	-	-	ADAD1	ENST00000296513,p.R224C|uc003iep.3,p.R224C|NM_139243,p.R224C|uc003ieq.3,p.R206C|ENST00000439307,p.R224C|NM_001159295,p.R206C|ENST00000388724,p.R224C|NM_001159285,p.R224C|uc003ieo.3,p.R224C|ENST00000388725,p.R206C	retained_intron, protein_coding, processed_transcript	uc003ieq.3	nonsynonymous SNV	exon6	c.C616T	p.R206C	IVKERFNQLISNRSEYLKYSSSLAA	IVKERFNQLISNCSEYLKYSSSLAA	1.0	9.0	-	-	3795_4:123317478-123317478 C>T_IVKERFNQLISNCSEYLKYSSSLAA	0.0
17:28849365-28849365 C>T	1.0	2369	MELANOMA	-	-	-	-	GOSR1	NM_001007024,p.T176I|ENST00000451249,p.T239I|uc002hfd.3,p.T239I|uc002hfe.3,p.T241I|ENST00000581721,p.T227I|NM_001007025,p.T239I|NM_004871,p.T241I|ENST00000225724,p.T241I|uc002hff.3,p.T176I|ENST00000467337,p.T176I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hff.3	nonsynonymous SNV	exon9	c.C527T	p.T176I	DSLILGGVIGICTILLLLYAFH	DSLILGGVIGICIILLLLYAFH	8.0	8.0	-	-	2369_17:28849365-28849365 C>T_DSLILGGVIGICIILLLLYAFH	0.0
1:244528039-244528039 C>T	0.0	3903	MELANOMA	-	-	ID=COSM228843;OCCURENCE=1(skin)	-	C1orf100	NM_001012970,p.R13C|NM_001276349,p.R13C|uc001iah.4,p.R13C|ENST00000308105,p.R13C|NM_001276348,p.R13C|ENST00000366537,p.R13C|uc001iai.4,p.R13C|uc031psw.1,p.R13C	protein_coding, processed_transcript	uc031psw.1	nonsynonymous SNV	exon2	c.C37T	p.R13C	MTAIRLREFIERRPVIPPSIFIAHQ	MTAIRLREFIERCPVIPPSIFIAHQ	3.0	10.0	-	-	3903_1:244528039-244528039 C>T_MTAIRLREFIERCPVIPPSIFIAHQ	0.0
12:7177845-7177845 G>A	1.0	4189	MELANOMA	-	-	-	-	C1S	uc001qsk.3,p.V653M|NM_001734,p.V653M|NM_201442,p.V653M|uc009zfr.3,p.V486M|ENST00000402681,p.V486M|ENST00000328916,p.V653M|ENST00000360817,p.V653M|ENST00000406697,p.V653M|uc001qsj.3,p.V653M|uc001qsl.3,p.V653M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zfr.3	nonsynonymous SNV	exon11	c.G1456A	p.V486M	PNDKTKFYAAGLVSWGPQCGTYGLY	PNDKTKFYAAGLMSWGPQCGTYGLY	10.0	4.0	-	-	4189_12:7177845-7177845 G>A_PNDKTKFYAAGLMSWGPQCGTYGLY	0.0
16:53261494-53261494 ->G	1.0	4278	COLORECTAL	-	-	-	-	CHD9	uc002ehb.3,p.F716fs|ENST00000398510,p.F716fs|uc002egy.3,p.F716fs|ENST00000566029,p.F716fs|ENST00000447540,p.F716fs|uc002ehd.2,p.F242fs|ENST00000565803,p.F242fs|ENST00000564845,p.F716fs|uc002ehc.3,p.F716fs|NM_025134,p.F716fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ehd.2	frameshift insertion	exon6	c.725_726insG	p.F242fs	EISPGVMIDTEEFFVKYKNYSYLHC	EISPGVMIDTEELFCKIQELLLSSL	9.0	1.0	-	-	4278_16:53261494-53261494 ->G_EISPGVMIDTEELFCKIQELLLSSL	0.0
2:220422584-220422584 G>A	0.0	4186	BREAST	-	-	-	-	OBSL1	NM_015311,p.P1251S|uc010zli.1,p.P150S|ENST00000404537,p.P1251S|ENST00000265317,p.P242S|uc010fwk.3,p.P1251S|uc002vmh.1,p.P242S|NM_001173431,p.P1251S|uc010fwl.2,p.P1251S|ENST00000373876,p.P1251S|ENST00000603926,p.P1251S|ENST00000265318,p.P1159S	retained_intron, protein_coding, processed_transcript	uc010zli.1	nonsynonymous SNV	exon3	c.C448T	p.P150S	HAGLYTCQSGAAPGAPSLSFTVQVA	HAGLYTCQSGAASGAPSLSFTVQVA	7.0	10.0	-	-	4186_2:220422584-220422584 G>A_HAGLYTCQSGAASGAPSLSFTVQVA	0.0
4:5687098-5687098 C>A	1.0	4129	NSCLC	-	-	-	-	EVC2	uc003gik.3,p.R192L|ENST00000509670,p.R192L|uc003gij.3,p.R272L|ENST00000344938,p.R272L|ENST00000310917,p.R192L|ENST00000475313,p.R192L|ENST00000344408,p.R272L|NM_001166136,p.R192L|NM_147127,p.R272L	protein_coding, nonsense_mediated_decay	uc003gik.3	nonsynonymous SNV	exon6	c.G575T	p.R192L	KLPAQLTFQSSSRNRTQLKVLFSIT	KLPAQLTFQSSSLNRTQLKVLFSIT	5.0	1.0	-	-	4129_4:5687098-5687098 C>A_KLPAQLTFQSSSLNRTQLKVLFSIT	0.0
6:26017750-26017750 C>A	0.0	4298	COLORECTAL	-	-	-	-	HIST1H1A	uc003nfo.3,p.A71S|ENST00000244573,p.A71S|NM_005325,p.A71S	protein_coding	uc003nfo.3	nonsynonymous SNV	exon1	c.G211T	p.A71S	GVSLAALKKALAAAGYDVEKNNSRI	GVSLAALKKALASAGYDVEKNNSRI	3.0	3.0	-	-	4298_6:26017750-26017750 C>A_GVSLAALKKALASAGYDVEKNNSRI	0.0
17:8172293-8172293 C>T	1.0	2369	MELANOMA	-	-	-	-	PFAS	NM_012393,p.P1243L|ENST00000545834,p.P819L|ENST00000314666,p.P1243L|uc002gkr.3,p.P1243L|uc010vuv.2,p.P819L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vuv.2	nonsynonymous SNV	exon26	c.C2456T	p.P819L	SAHGEGYVAFSSPELQAQIEARGLA	SAHGEGYVAFSSLELQAQIEARGLA	8.0	9.0	-	-	2369_17:8172293-8172293 C>T_SAHGEGYVAFSSLELQAQIEARGLA	0.0
16:26147468-26147468 G>A	0.0	4298	COLORECTAL	-	-	-	-	HS3ST4	uc002dof.3,p.V424I|ENST00000331351,p.V424I|NM_006040,p.V424I	protein_coding, processed_transcript	uc002dof.3	nonsynonymous SNV	exon2	c.G1270A	p.V424I	SKGRTHPRIDPDVIHRLRKFYKPFN	SKGRTHPRIDPDIIHRLRKFYKPFN	3.0	9.0	-	-	4298_16:26147468-26147468 G>A_SKGRTHPRIDPDIIHRLRKFYKPFN	0.0
12:81545861-81545862 AC>-	0.0	4346	COLORECTAL	-	-	-	-	ACSS3	ENST00000548058,p.T362fs|ENST00000261206,p.T361fs|uc001szl.1,p.T362fs|uc001szm.1,p.T361fs|NM_024560,p.T362fs|ENST00000548324,p.T44fs|uc001szn.1,p.T44fs	retained_intron, protein_coding, nonsense_mediated_decay	uc001szn.1	frameshift deletion	exon2	c.130_131del	p.T44fs	YICYGPLLHGNTTVLYEGKPVGTPDA	YICYGPLLHGNTSFI	4.0	1.0	-	-	4346_12:81545861-81545862 AC>-_YICYGPLLHGNTSFI	0.0
1:160247932-160247932 A>G	1.0	4316	COLORECTAL	-	-	-	-	PEX19	ENST00000556710,p.L142P|uc010pjc.1,p.L142P	protein_coding	uc010pjc.1	nonsynonymous SNV	exon6	c.T425C	p.L142P	FFCGSQWVYGPWLTYVGWLQQTSFK	FFCGSQWVYGPWPTYVGWLQQTSFK	7.0	7.0	-	-	4316_1:160247932-160247932 A>G_FFCGSQWVYGPWPTYVGWLQQTSFK	0.0
1:28293115-28293115 G>A	1.0	3466	MELANOMA	-	-	-	-	XKR8	ENST00000373884,p.G198S|NM_018053,p.G198S|uc001bph.1,p.G198S	protein_coding, processed_transcript	uc001bph.1	nonsynonymous SNV	exon3	c.G592A	p.G198S	RTCLPSKPLLGLGSSVIYFLWNLLL	RTCLPSKPLLGLSSSVIYFLWNLLL	4.0	8.0	-	-	3466_1:28293115-28293115 G>A_RTCLPSKPLLGLSSSVIYFLWNLLL	0.0
20:49509002-49509002 A>C	1.0	4335	COLORECTAL	-	-	-	-	ADNP	ENST00000396032,p.V750G|ENST00000349014,p.V750G|NM_015339,p.V750G|ENST00000396029,p.V750G|ENST00000371602,p.V750G|uc002xvt.1,p.V750G|NM_001282531,p.V750G|NM_181442,p.V750G|uc002xvu.1,p.V750G|NM_001282532,p.V750G	protein_coding	uc002xvu.1	nonsynonymous SNV	exon4	c.T2249G	p.V750G	SPSFFEEKPEEPVVLALDPKGHEDD	SPSFFEEKPEEPGVLALDPKGHEDD	7.0	4.0	-	-	4335_20:49509002-49509002 A>C_SPSFFEEKPEEPGVLALDPKGHEDD	0.0
20:57428808-57428808 C>T	0.0	4189	MELANOMA	-	-	-	1	GNAS	NM_001077490,p.P101S|ENST00000306120,p.P100S	retained_intron, protein_coding, processed_transcript	NM_001077490	nonsynonymous SNV	exon1	c.C301T	p.P101S	WEDTALHQKKLCPLSLTSLPREAAV	WEDTALHQKKLCSLSLTSLPREAAV	10.0	3.0	-	-	4189_20:57428808-57428808 C>T_WEDTALHQKKLCSLSLTSLPREAAV	0.0
3:168833264-168833264 C>T	1.0	3713	MELANOMA	-	-	-	1	MECOM	NM_001105078,p.G611E|ENST00000464456,p.G611E|ENST00000494292,p.G799E|uc003ffi.3,p.G611E|NM_001164000,p.G611E|ENST00000433243,p.G612E|uc011bpk.1,p.G611E|NM_001163999,p.G612E|uc010hwk.1,p.G634E|ENST00000392736,p.G611E|ENST00000460814,p.G611E|ENST00000472280,p.G612E|uc011bpj.1,p.G799E|uc010hwn.2,p.G799E|uc003ffn.3,p.G611E|ENST00000264674,p.G676E|NM_005241,p.G611E|NM_001205194,p.G611E|uc011bpi.1,p.G612E|NM_004991,p.G799E|uc003ffk.2,p.G611E|NM_001105077,p.G676E|ENST00000492586,p.G262E|uc003ffj.3,p.G676E|ENST00000468789,p.G611E|uc003ffl.2,p.G771E	retained_intron, protein_coding, processed_transcript	uc011bpk.1	nonsynonymous SNV	exon7	c.G1832A	p.G611E	KLTEPRKNHVFGGKKGSNVESRPAS	KLTEPRKNHVFGEKKGSNVESRPAS	2.0	2.0	-	-	3713_3:168833264-168833264 C>T_KLTEPRKNHVFGEKKGSNVESRPAS	0.0
10:50340326-50340326 C>T	0.0	4287	COLORECTAL	-	-	-	-	FAM170B	uc001jhj.3,p.A62T|NM_001164484,p.A62T|ENST00000311787,p.A62T	protein_coding	uc001jhj.3	nonsynonymous SNV	exon2	c.G184A	p.A62T	GPAIPREEGLYFAARDRGMRDWSSS	GPAIPREEGLYFTARDRGMRDWSSS	1.0	10.0	-	-	4287_10:50340326-50340326 C>T_GPAIPREEGLYFTARDRGMRDWSSS	0.0
3:189712072-189712072 C>T	1.0	3713	MELANOMA	-	-	-	-	LEPREL1	uc011bsk.2,p.E212K|NM_018192,p.E212K|ENST00000444866,p.E31K|NM_001134418,p.E31K|ENST00000319332,p.E212K|ENST00000427335,p.E31K|uc003fsg.3,p.E31K|ENST00000426003,p.E31K	retained_intron, protein_coding	uc011bsk.2	nonsynonymous SNV	exon3	c.G634A	p.E212K	LQLVDREAKPHMESYNAGVKHYEAD	LQLVDREAKPHMKSYNAGVKHYEAD	2.0	7.0	-	-	3713_3:189712072-189712072 C>T_LQLVDREAKPHMKSYNAGVKHYEAD	0.0
5:886726-886726 G>A	1.0	3466	MELANOMA	-	-	-	-	BRD9	ENST00000467963,p.P272S|uc003jbq.3,p.P272S|ENST00000483173,p.P219S|NM_023924,p.P272S|uc003jbl.3,p.P156S|ENST00000435709,p.P156S|uc003jbo.3,p.P176S|ENST00000489093,p.P176S|ENST00000388890,p.P156S|ENST00000323510,p.P176S|NM_001009877,p.P219S|uc011cmb.2,p.P219S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cmb.2	nonsynonymous SNV	exon7	c.C655T	p.P219S	PVQVETAKKSKKPSREVISCMFEPE	PVQVETAKKSKKSSREVISCMFEPE	7.0	7.0	-	-	3466_5:886726-886726 G>A_PVQVETAKKSKKSSREVISCMFEPE	0.0
4:72620224-72620224 C>T	0.0	4196	COLORECTAL	-	-	-	-	GC	uc010iif.3,p.G408D|NM_001204306,p.G389D|ENST00000273951,p.G389D|uc021xpb.1,p.G389D|ENST00000513476,p.G389D|uc003hge.3,p.G389D|ENST00000504199,p.G408D|NM_001204307,p.G408D|NM_000583,p.G389D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xpb.1	nonsynonymous SNV	exon11	c.G1166A	p.G389D	DVEDSTTCFNAKGPLLKKELSSFID	DVEDSTTCFNAKDPLLKKELSSFID	2.0	10.0	-	-	4196_4:72620224-72620224 C>T_DVEDSTTCFNAKDPLLKKELSSFID	0.0
5:101813455-101813455 C>T	0.0	3903	MELANOMA	-	-	-	-	SLCO6A1	uc003knn.3,p.G243R|NM_173488,p.G243R|ENST00000506729,p.G243R|NM_001289002,p.G243R|ENST00000379807,p.G243R|uc003knp.3,p.G243R	retained_intron, protein_coding, processed_transcript	uc003knp.3	nonsynonymous SNV	exon3	c.G727A	p.G243R	FFILGQTVQGIAGMPLYILGITFID	FFILGQTVQGIARMPLYILGITFID	2.0	2.0	-	-	3903_5:101813455-101813455 C>T_FFILGQTVQGIARMPLYILGITFID	0.0
19:45563845-45563845 C>T	1.0	3466	MELANOMA	-	-	ID=COSM247283;OCCURENCE=1(endometrium),1(prostate)	-	CLASRP	uc010xxh.2,p.R213W|uc002pam.3,p.R275W|ENST00000391952,p.R275W|NM_007056,p.R275W|ENST00000221455,p.R275W|ENST00000391953,p.R213W|ENST00000544944,p.R275W|NM_001278439,p.R213W|uc002pak.3,p.R275W	retained_intron, protein_coding, nonsense_mediated_decay	uc010xxh.2	nonsynonymous SNV	exon9	c.C637T	p.R213W	SGRRSRRQRREFREKRLRGRKISPP	SGRRSRRQRREFWEKRLRGRKISPP	9.0	1.0	-	-	3466_19:45563845-45563845 C>T_SGRRSRRQRREFWEKRLRGRKISPP	0.0
2:220197278-220197278 C>A	0.0	4213	COLORECTAL	-	-	-	-	RESP18	NM_001007089,p.C67F|uc002vlc.4,p.C67F|ENST00000333527,p.C67F	retained_intron, protein_coding	uc002vlc.4	nonsynonymous SNV	exon2	c.G200T	p.C67F	LQLLVCFLLLNSCPGGCSDTSAHDG	LQLLVCFLLLNSFPGGCSDTSAHDG	1.0	10.0	-	-	4213_2:220197278-220197278 C>A_LQLLVCFLLLNSFPGGCSDTSAHDG	0.0
4:115998158-115998158 C>T	0.0	4275	COLORECTAL	0.01	rs35181627	ID=COSM3696401;OCCURENCE=1(large_intestine)	-	NDST4	ENST00000264363,p.R12Q|NM_022569,p.R12Q|uc003ibu.3,p.R12Q	retained_intron, protein_coding, nonsense_mediated_decay	uc003ibu.3	nonsynonymous SNV	exon2	c.G35A	p.R12Q	MNLIVKLRRSFRTLIVLLATFCLV	MNLIVKLRRSFQTLIVLLATFCLV	1.0	3.0	-	-	4275_4:115998158-115998158 C>T_MNLIVKLRRSFQTLIVLLATFCLV	0.0
11:1093274-1093274 C>T	0.0	4346	COLORECTAL	-	-	-	-	MUC2	ENST00000359061,p.S1665L|ENST00000441003,p.S1698L	protein_coding	ENST00000441003	nonsynonymous SNV	exon30	c.C5093T	p.S1698L	PTPTPTGTQTPTSTPITTTTTVTPT	PTPTPTGTQTPTLTPITTTTTVTPT	4.0	4.0	-	-	4346_11:1093274-1093274 C>T_PTPTPTGTQTPTLTPITTTTTVTPT	0.0
1:92442634-92442634 C>T	0.0	4246	COLORECTAL	-	-	-	-	BRDT	ENST00000370389,p.T145I|uc001dom.4,p.T218I|ENST00000426141,p.T218I|NM_001726,p.T218I|uc010otb.2,p.T172I|uc010osz.2,p.T222I|uc001dok.4,p.T218I|NM_001242806,p.T222I|ENST00000402388,p.T218I|uc010ota.2,p.T172I|NM_001242810,p.T145I|ENST00000399546,p.T218I|NM_207189,p.T218I|ENST00000362005,p.T218I|uc001dol.4,p.T218I|NM_001242808,p.T172I|NM_001242807,p.T172I|NM_001242805,p.T218I|uc009wdf.3,p.T145I|ENST00000394530,p.T172I	protein_coding, processed_transcript	uc010otb.2	nonsynonymous SNV	exon5	c.C515T	p.T172I	QVTKGVKRKADTTTPATSAVKASSE	QVTKGVKRKADTITPATSAVKASSE	2.0	7.0	-	-	4246_1:92442634-92442634 C>T_QVTKGVKRKADTITPATSAVKASSE	0.0
15:99901582-99901582 C>T	1.0	3713	MELANOMA	-	-	-	-	LRRC28	uc010uru.1,p.S177F|ENST00000447360,p.S246F|ENST00000422500,p.S177F|NM_144598,p.S246F|uc010urt.1,p.S60F|ENST00000561276,p.S201F|uc002bvb.1,p.S92F|ENST00000301981,p.S246F|ENST00000558172,p.S142F|uc002bva.1,p.S246F|NM_001284400,p.S246F|uc002bvc.1,p.S246F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uru.1	nonsynonymous SNV	exon7	c.C530T	p.S177F	GAPIQVSEVKLLSFSSGQRTVFLPA	GAPIQVSEVKLLFFSSGQRTVFLPA	7.0	9.0	-	-	3713_15:99901582-99901582 C>T_GAPIQVSEVKLLFFSSGQRTVFLPA	0.0
9:16435575-16435575 G>A	1.0	3716	MELANOMA	-	-	-	-	BNC2	uc003zml.3,p.P873S|ENST00000380667,p.P806S|uc011lmw.2,p.P778S|ENST00000545497,p.P778S|ENST00000380672,p.P873S|NM_017637,p.P873S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011lmw.2	nonsynonymous SNV	exon5	c.C2332T	p.P778S	HVCTVAGCNAAFPSRRSRDRHSANI	HVCTVAGCNAAFSSRRSRDRHSANI	9.0	10.0	-	-	3716_9:16435575-16435575 G>A_HVCTVAGCNAAFSSRRSRDRHSANI	0.0
11:59211439-59211439 C>A	0.0	4278	COLORECTAL	-	-	-	-	OR5A1	NM_001004728,p.S266R|uc001nnx.1,p.S266R|ENST00000302030,p.S266R	protein_coding	uc001nnx.1	nonsynonymous SNV	exon1	c.C798A	p.S266R	LFGTALFVYLRPSSSYLLGRDKVVS	LFGTALFVYLRPRSSYLLGRDKVVS	1.0	9.0	-	-	4278_11:59211439-59211439 C>A_LFGTALFVYLRPRSSYLLGRDKVVS	0.0
7:2412349-2412349 T>C	1.0	2359	MELANOMA	-	-	-	-	EIF3B	uc003sly.3,p.F577L|uc003sma.3,p.F305L|NM_001037283,p.F577L|ENST00000360876,p.F577L|NM_003751,p.F577L|ENST00000397011,p.F577L|uc003slx.3,p.F577L	retained_intron, protein_coding	uc003sma.3	nonsynonymous SNV	exon11	c.T913C	p.F305L	IIAFAWEPNGSKFAVLHGEAPRISV	IIAFAWEPNGSKLAVLHGEAPRISV	10.0	5.0	-	-	2359_7:2412349-2412349 T>C_IIAFAWEPNGSKLAVLHGEAPRISV	0.0
17:48626839-48626839 C>T	1.0	3784	MELANOMA	-	-	-	-	SPATA20	uc002ire.3,p.P225S|NM_001258372,p.P269S|ENST00000006658,p.P285S|uc010wmv.1,p.P295S|NM_001258373,p.P225S|uc002irf.3,p.P269S|NM_022827,p.P285S|ENST00000356488,p.P269S|uc002ird.3,p.P285S|ENST00000393244,p.P225S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wmv.1	nonsynonymous SNV	exon5	c.C883T	p.P295S	EEYGGFAEAPKFPTPVILSFLFSYW	EEYGGFAEAPKFSTPVILSFLFSYW	9.0	4.0	-	-	3784_17:48626839-48626839 C>T_EEYGGFAEAPKFSTPVILSFLFSYW	0.0
20:42315517-42315517 G>A	1.0	3466	MELANOMA	-	-	-	-	MYBL2	ENST00000217026,p.G102D|uc002xlb.1,p.G102D|ENST00000396863,p.G78D|uc010zwj.1,p.G78D|NM_001278610,p.G78D|NM_002466,p.G102D	protein_coding	uc010zwj.1	nonsynonymous SNV	exon4	c.G233A	p.G78D	EDQKVIELVKKYGTKQWTLIAKHLK	EDQKVIELVKKYDTKQWTLIAKHLK	4.0	5.0	-	-	3466_20:42315517-42315517 G>A_EDQKVIELVKKYDTKQWTLIAKHLK	0.0
2:157413913-157413913 G>T	1.0	4129	NSCLC	-	-	-	-	GPD2	ENST00000438166,p.M328I|ENST00000409674,p.M328I|uc002tzd.4,p.M328I|ENST00000310454,p.M328I|NM_001083112,p.M328I|ENST00000409861,p.M328I|ENST00000409125,p.M101I|uc002tzf.4,p.M328I|NM_000408,p.M328I|ENST00000540309,p.M328I|uc010zch.2,p.M101I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zch.2	nonsynonymous SNV	exon5	c.G303T	p.M101I	HIVMPGYYSPESMGLLDPATSDGRV	HIVMPGYYSPESIGLLDPATSDGRV	8.0	4.0	-	-	4129_2:157413913-157413913 G>T_HIVMPGYYSPESIGLLDPATSDGRV	0.0
4:2966983-2966983 G>A	0.0	4081	COLORECTAL	-	-	-	-	GRK4	ENST00000442472,p.A52T|uc003ggm.3,p.A52T	retained_intron, protein_coding, processed_transcript	uc003ggm.3	nonsynonymous SNV	exon2	c.G154A	p.A52T	AAAESASSPLHPATKASVGPALQRE	AAAESASSPLHPTTKASVGPALQRE	3.0	9.0	-	-	4081_4:2966983-2966983 G>A_AAAESASSPLHPTTKASVGPALQRE	0.0
9:77390974-77390974 C>T	0.0	2556	MELANOMA	-	-	-	-	TRPM6	ENST00000451710,p.M1076I|uc004ajl.1,p.M1076I|ENST00000449912,p.M1071I|NM_001177311,p.M1071I|ENST00000376864,p.M1076I|ENST00000361255,p.M1071I|uc004ajk.1,p.M1071I|NM_017662,p.M1076I|ENST00000360774,p.M1076I|uc022bib.1,p.M1071I|NM_001177310,p.M1071I	protein_coding, processed_transcript	uc022bib.1	nonsynonymous SNV	exon24	c.G3213A	p.M1071I	LLIAFFNNVYLDMESISNNLWKYNR	LLIAFFNNVYLDIESISNNLWKYNR	1.0	5.0	-	-	2556_9:77390974-77390974 C>T_LLIAFFNNVYLDIESISNNLWKYNR	0.0
7:39125584-39125584 C>A	1.0	4234	NSCLC	-	-	-	-	POU6F2	uc022acb.1,p.A48E|ENST00000524147,p.A40E|ENST00000464276,p.A40E|ENST00000559001,p.A40E|ENST00000403058,p.A48E|ENST00000520104,p.A40E|uc010kxo.3,p.A40E|ENST00000451021,p.A49E|uc003thb.2,p.A48E|ENST00000518318,p.A48E|NM_007252,p.A48E|NM_001166018,p.A48E	protein_coding, processed_transcript, nonsense_mediated_decay	uc022acb.1	nonsynonymous SNV	exon3	c.C143A	p.A48E	ATSDSELNEPLLAPVESNDSEDTPS	ATSDSELNEPLLEPVESNDSEDTPS	5.0	7.0	-	-	4234_7:39125584-39125584 C>A_ATSDSELNEPLLEPVESNDSEDTPS	0.0
3:108344713-108344713 A>-	1.0	4298	COLORECTAL	-	-	-	-	DZIP3	ENST00000479138,p.K160fs|NM_014648,p.K160fs|ENST00000486815,p.K76fs|ENST00000361582,p.K160fs|ENST00000495008,p.K160fs|uc003dxe.1,p.K160fs|uc003dxd.3,p.K160fs|uc003dxf.1,p.K160fs|ENST00000463306,p.K160fs	protein_coding, nonsense_mediated_decay	uc003dxf.1	frameshift deletion	exon7	c.478delA	p.K160fs	RGKKEDYTEAENKFLVMKMMIQENE	RGKKEDYTEAENNFW	6.0	9.0	-	-	4298_3:108344713-108344713 A>-_RGKKEDYTEAENNFW	0.0
16:1604966-1604966 G>A	0.0	2359	MELANOMA	-	-	-	-	TMEM204	NM_001256541,p.R207H|ENST00000566264,p.R207H|NM_024600,p.R207H|ENST00000253934,p.R207H|uc002cmd.3,p.R207H|uc002cmc.3,p.R207H	protein_coding	uc002cmd.3	nonsynonymous SNV	exon3	c.G620A	p.R207H	EDCMAPRVIVISRSLTARFRRGLDN	EDCMAPRVIVISHSLTARFRRGLDN	2.0	7.0	-	-	2359_16:1604966-1604966 G>A_EDCMAPRVIVISHSLTARFRRGLDN	0.0
19:46281432-46281432 G>A	1.0	4129	NSCLC	-	-	-	-	DMPK	uc010xxs.1,p.R121C|uc002pdd.1,p.R220C|NM_001081560,p.R210C|NM_001288766,p.R210C|uc002pdh.1,p.R210C|uc002pdg.1,p.R210C|NM_001081562,p.R210C|ENST00000600757,p.R220C|uc002pdi.1,p.R236C|ENST00000291270,p.R210C|NM_001081563,p.R220C|NM_001288765,p.R121C|ENST00000354227,p.R210C|ENST00000458663,p.R210C|NM_001288764,p.R236C|uc002pde.1,p.R220C|uc010xxt.1,p.R210C|ENST00000447742,p.R210C|ENST00000343373,p.R220C|NM_004409,p.R210C|uc002pdf.1,p.R210C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xxt.1	nonsynonymous SNV	exon6	c.C628T	p.R210C	PDNILLDRCGHIRLADFGSCLKLRA	PDNILLDRCGHICLADFGSCLKLRA	8.0	8.0	-	-	4129_19:46281432-46281432 G>A_PDNILLDRCGHICLADFGSCLKLRA	0.0
17:78071170-78071170 G>A	0.0	4301	MELANOMA	-	-	-	-	CCDC40	uc010dht.3,p.D1050N|uc002jxn.4,p.D446N|NM_017950,p.D1050N|ENST00000397545,p.D1050N|uc002jxm.4,p.D833N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dht.3	nonsynonymous SNV	exon19	c.G3148A	p.D1050N	SVIQADFDTLEADLTRLGALKRQNL	SVIQADFDTLEANLTRLGALKRQNL	6.0	2.0	-	-	4301_17:78071170-78071170 G>A_SVIQADFDTLEANLTRLGALKRQNL	0.0
5:38506168-38506168 C>T	1.0	3919	MELANOMA	-	-	-	1	LIFR	NM_002310,p.G377E|NM_001127671,p.G377E|uc003jli.2,p.G377E|ENST00000263409,p.G377E|ENST00000453190,p.G377E|uc010ive.1,p.G377E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ive.1	nonsynonymous SNV	exon9	c.G1130A	p.G377E	RATSYTLVESFSGKYVRLKRAEAPT	RATSYTLVESFSEKYVRLKRAEAPT	3.0	10.0	-	-	3919_5:38506168-38506168 C>T_RATSYTLVESFSEKYVRLKRAEAPT	0.0
1:233497848-233497848 A>C	0.0	4245	COLORECTAL	-	-	-	-	KIAA1804	uc001hvs.1,p.K454T|ENST00000366623,p.K454T|uc001hvt.4,p.K454T|ENST00000366624,p.K454T|NM_032435,p.K454T	protein_coding	uc001hvt.4	nonsynonymous SNV	exon5	c.A1361C	p.K454T	REEELTRAALQQKSQEELLKRREQQ	REEELTRAALQQTSQEELLKRREQQ	7.0	2.0	-	-	4245_1:233497848-233497848 A>C_REEELTRAALQQTSQEELLKRREQQ	0.0
3:52246364-52246364 C>T	1.0	4317	COLORECTAL	-	-	-	-	ALAS1	ENST00000394965,p.P564S|ENST00000469224,p.P564S|ENST00000310271,p.P564S|NM_199166,p.P564S|uc011bec.2,p.P581S|uc003dcy.2,p.P564S|NM_000688,p.P564S|ENST00000484952,p.P564S|uc003dcz.2,p.P564S	protein_coding	uc011bec.2	nonsynonymous SNV	exon11	c.C1741T	p.P581S	NIYVQAINYPTVPRGEELLRIAPTP	NIYVQAINYPTVSRGEELLRIAPTP	8.0	9.0	-	-	4317_3:52246364-52246364 C>T_NIYVQAINYPTVSRGEELLRIAPTP	0.0
8:25182901-25182901 G>C	1.0	4244	COLORECTAL	-	-	-	-	DOCK5	NM_024940,p.D581H|uc003xeg.3,p.D581H|ENST00000276440,p.D581H|uc003xeh.1,p.D295H|uc003xei.3,p.D151H	retained_intron, protein_coding, nonsense_mediated_decay	uc003xei.3	nonsynonymous SNV	exon6	c.G451C	p.D151H	LVVYKGDNKKMEDAKFYLTLPGTKM	LVVYKGDNKKMEHAKFYLTLPGTKM	8.0	5.0	-	-	4244_8:25182901-25182901 G>C_LVVYKGDNKKMEHAKFYLTLPGTKM	0.0
16:27781308-27781308 C>T	1.0	4081	COLORECTAL	-	-	-	-	KIAA0556	NM_015202,p.R1368W|uc002dow.3,p.R1368W|ENST00000261588,p.R1368W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dow.3	nonsynonymous SNV	exon21	c.C4102T	p.R1368W	DFAQEILFVDYLRAQLLPQPARRLD	DFAQEILFVDYLWAQLLPQPARRLD	7.0	3.0	-	-	4081_16:27781308-27781308 C>T_DFAQEILFVDYLWAQLLPQPARRLD	0.0
13:38357308-38357308 C>G	0.0	4196	COLORECTAL	-	-	-	-	TRPC4	uc010abx.3,p.A55P|ENST00000358477,p.A55P|NM_003306,p.A55P|uc010tey.2,p.A55P|ENST00000379673,p.A55P|uc010aby.3,p.A55P|uc010abw.3,p.A55P|NM_016179,p.A55P|ENST00000447043,p.A55P|ENST00000379681,p.A55P|NM_001135956,p.A55P|NM_001135958,p.A55P|NM_001135955,p.A55P|ENST00000488717,p.A55P|ENST00000426868,p.A55P|ENST00000379705,p.A55P|ENST00000355779,p.A55P|ENST00000379679,p.A55P|ENST00000338947,p.A55P|uc001uwt.3,p.A55P|NM_001135957,p.A55P|uc001uws.3,p.A55P	protein_coding, processed_transcript, nonsense_mediated_decay	uc010tey.2	nonsynonymous SNV	exon2	c.G163C	p.A55P	GDYASVKKSLEEAEIYFKININCID	GDYASVKKSLEEPEIYFKININCID	5.0	4.0	-	-	4196_13:38357308-38357308 C>G_GDYASVKKSLEEPEIYFKININCID	0.0
16:31927698-31927698 C>T	1.0	4000	MELANOMA	-	-	-	-	ZNF267	uc031qvx.1,p.H678Y|ENST00000300870,p.H710Y|uc031qvw.1,p.H454Y|uc002ecs.5,p.H710Y|NM_003414,p.H710Y|NM_001265588,p.H678Y	protein_coding, nonsense_mediated_decay	uc031qvx.1	nonsynonymous SNV	exon5	c.C2032T	p.H678Y	SYRSYLTTHRRSHSGERPYKCEECG	SYRSYLTTHRRSYSGERPYKCEECG	8.0	1.0	-	-	4000_16:31927698-31927698 C>T_SYRSYLTTHRRSYSGERPYKCEECG	0.0
7:44578620-44578620 G>A	0.0	3998	MELANOMA	-	-	-	-	NPC1L1	uc003tlc.3,p.P459L|ENST00000546276,p.P459L|NM_001300967,p.P459L|NM_013389,p.P459L|uc011kbw.2,p.P459L|ENST00000289547,p.P459L|NM_001101648,p.P459L|uc003tlb.3,p.P459L|ENST00000381160,p.P459L|uc003tld.3,p.P459L|ENST00000423141,p.P459L	protein_coding	uc011kbw.2	nonsynonymous SNV	exon2	c.C1376T	p.P459L	LQERLRHLQVWSPEAQRNISLQDIC	LQERLRHLQVWSLEAQRNISLQDIC	1.0	8.0	-	-	3998_7:44578620-44578620 G>A_LQERLRHLQVWSLEAQRNISLQDIC	0.0
8:144993955-144993955 C>G	1.0	4240	BREAST	-	-	-	-	PLEC	ENST00000345136,p.G3345A|uc003zad.2,p.G3345A|ENST00000436759,p.G3372A|ENST00000322810,p.G3482A|ENST00000356346,p.G3331A|NM_201382,p.G3345A|uc003zaj.2,p.G3372A|uc003zab.1,p.G3345A|uc003zae.1,p.G3313A|ENST00000527096,p.G3368A|NM_201380,p.G3482A|ENST00000354589,p.G3345A|NM_201384,p.G3345A|uc003zaf.1,p.G3482A|uc003zag.1,p.G3323A|NM_201379,p.G3323A|uc003zah.2,p.G3331A|ENST00000357649,p.G3349A|ENST00000354958,p.G3323A|ENST00000398774,p.G3313A|NM_201378,p.G3331A|NM_201381,p.G3313A|NM_000445,p.G3372A|NM_201383,p.G3349A|uc003zac.1,p.G3349A	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon33	c.G10115C	p.G3372A	DGKTTVKDLSELGSVRTLLQGSGCL	DGKTTVKDLSELASVRTLLQGSGCL	9.0	2.0	-	-	4240_8:144993955-144993955 C>G_DGKTTVKDLSELASVRTLLQGSGCL	0.0
16:1252066-1252066 C>T	0.0	2556	MELANOMA	-	-	-	-	CACNA1H	ENST00000565831,p.P539L|NM_021098,p.P539L|ENST00000348261,p.P539L|uc002ckt.3,p.P539L|ENST00000358590,p.P539L|NM_001005407,p.P539L|uc002cks.3,p.P539L	retained_intron, protein_coding	uc002ckt.3	nonsynonymous SNV	exon9	c.C1616T	p.P539L	HHYHFSHGSPRRPGPEPGACDTRLV	HHYHFSHGSPRRLGPEPGACDTRLV	4.0	9.0	-	-	2556_16:1252066-1252066 C>T_HHYHFSHGSPRRLGPEPGACDTRLV	0.0
9:84604718-84604718 G>A	0.0	3795	MELANOMA	-	-	-	-	SPATA31D1	ENST00000344803,p.R71K|NM_001001670,p.R71K|uc004amn.3,p.R71K	protein_coding	uc004amn.3	nonsynonymous SNV	exon2	c.G212A	p.R71K	DIQKHQGRAKRRRKGGTFKGFPDWK	DIQKHQGRAKRRKKGGTFKGFPDWK	1.0	1.0	-	-	3795_9:84604718-84604718 G>A_DIQKHQGRAKRRKKGGTFKGFPDWK	0.0
15:23811360-23811360 G>A	1.0	3716	MELANOMA	-	-	-	-	MKRN3	uc010ayi.1,p.S144N|ENST00000314520,p.S144N|uc001ywh.4,p.S144N|NM_005664,p.S144N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ayi.1	nonsynonymous SNV	exon1	c.G431A	p.S144N	VSPPGASAGGGPSTAAHIEPPTQEV	VSPPGASAGGGPNTAAHIEPPTQEV	6.0	6.0	-	-	3716_15:23811360-23811360 G>A_VSPPGASAGGGPNTAAHIEPPTQEV	0.0
16:3165842-3165842 C>T	1.0	3713	MELANOMA	-	-	-	-	ZNF205	ENST00000414351,p.P95L|ENST00000444510,p.P95L|NM_003456,p.P95L|NM_001278158,p.P95L|uc031quw.1,p.P95L|uc002cua.3,p.P95L|ENST00000382192,p.P95L|NM_001042428,p.P95L|uc002cub.3,p.P95L|ENST00000219091,p.P95L	protein_coding	uc031quw.1	nonsynonymous SNV	exon4	c.C284T	p.P95L	KALFLPGGALPSPRIPVLSREGRTR	KALFLPGGALPSLRIPVLSREGRTR	5.0	8.0	-	-	3713_16:3165842-3165842 C>T_KALFLPGGALPSLRIPVLSREGRTR	0.0
13:99566616-99566616 G>A	0.0	2359	MELANOMA	-	-	-	-	DOCK9	ENST00000448493,p.S321F|uc021rlw.1,p.S309F|ENST00000442173,p.S309F|NM_001130050,p.S309F|ENST00000339416,p.S310F|uc010tit.1,p.S310F|uc010afu.1,p.S125F|ENST00000376460,p.S309F|uc010tir.1,p.S310F|uc001vnt.2,p.S310F|uc001vnw.2,p.S309F|uc010tis.1,p.S309F|NM_001130049,p.S310F	protein_coding, processed_transcript	uc021rlw.1	nonsynonymous SNV	exon9	c.C926T	p.S309F	EDDEQSKLEGSGSGLDSYLPELAKS	EDDEQSKLEGSGFGLDSYLPELAKS	8.0	5.0	-	-	2359_13:99566616-99566616 G>A_EDDEQSKLEGSGFGLDSYLPELAKS	0.0
1:6219425-6219425 C>T	0.0	4160	COLORECTAL	-	-	-	-	CHD5	ENST00000262450,p.E120K|uc001amb.2,p.E120K|NM_015557,p.E120K|ENST00000496404,p.E120K	protein_coding, nonsense_mediated_decay	uc001amb.2	nonsynonymous SNV	exon3	c.G358A	p.E120K	EKKAKRKKKDEDEDDNDDGCLKEPK	EKKAKRKKKDEDKDDNDDGCLKEPK	4.0	3.0	-	-	4160_1:6219425-6219425 C>T_EKKAKRKKKDEDKDDNDDGCLKEPK	0.0
17:17699795-17699795 T>C	0.0	4081	COLORECTAL	-	-	-	-	RAI1	ENST00000261641,p.L1178P|uc002grn.1,p.L1178P|ENST00000353383,p.L1178P|uc002grm.3,p.L1178P|NM_030665,p.L1178P	sense_intronic, protein_coding, processed_transcript	uc002grn.1	nonsynonymous SNV	exon2	c.T3533C	p.L1178P	GRLPNCRATKKLLDNSHLPATFKVS	GRLPNCRATKKLPDNSHLPATFKVS	10.0	5.0	-	-	4081_17:17699795-17699795 T>C_GRLPNCRATKKLPDNSHLPATFKVS	0.0
13:21555646-21555646 C>T	1.0	3919	MELANOMA	-	-	-	-	LATS2	ENST00000382592,p.G875E|uc001unr.4,p.G875E|uc009zzs.3,p.G875E|ENST00000542899,p.G875E|NM_014572,p.G875E	protein_coding, processed_transcript	uc009zzs.3	nonsynonymous SNV	exon6	c.G2624A	p.G875E	KQHQRCLAHSLVGTPNYIAPEVLLR	KQHQRCLAHSLVETPNYIAPEVLLR	7.0	3.0	-	-	3919_13:21555646-21555646 C>T_KQHQRCLAHSLVETPNYIAPEVLLR	0.0
19:40899992-40899992 T>C	0.0	4335	COLORECTAL	-	-	-	-	PRX	uc002onq.3,p.S1284G|uc002onr.3,p.S1423G|NM_181882,p.S1423G|ENST00000324001,p.S1423G	protein_coding, processed_transcript	uc002onr.3	nonsynonymous SNV	exon7	c.A4267G	p.S1423G	RFPRVSLSPKARSGSGDQEEGGLRV	RFPRVSLSPKARGGSGDQEEGGLRV	8.0	7.0	-	-	4335_19:40899992-40899992 T>C_RFPRVSLSPKARGGSGDQEEGGLRV	0.0
2:152376249-152376249 C>T	1.0	4000	MELANOMA	-	-	-	-	NEB	NM_001164508,p.G7505S|uc031rpp.1,p.G7540S|uc002txt.4,p.G309S|ENST00000604864,p.G7505S|ENST00000427231,p.G7505S|ENST00000603639,p.G7505S|uc021vrd.1,p.G5804S|uc021vrb.1,p.G5804S|ENST00000172853,p.G5804S|ENST00000409198,p.G5804S|NM_001164507,p.G7505S|ENST00000397345,p.G7505S|ENST00000413693,p.G2235S|NM_001271208,p.G7540S|uc002txr.3,p.G2270S|uc002txu.3,p.G7505S|uc021vrc.1,p.G7505S	retained_intron, protein_coding, processed_transcript	uc031rpp.1	nonsynonymous SNV	exon155	c.G22618A	p.G7540S	QVKYRENFDKEKGKTPKYNPKDSQL	QVKYRENFDKEKSKTPKYNPKDSQL	4.0	7.0	-	-	4000_2:152376249-152376249 C>T_QVKYRENFDKEKSKTPKYNPKDSQL	0.0
12:108012027-108012027 C>T	0.0	3903	MELANOMA	-	-	ID=COSM69855;OCCURENCE=1(ovary)	-	BTBD11	uc001tmk.1,p.A775V|NM_001018072,p.A775V|ENST00000357167,p.A312V|NM_001017523,p.A312V|uc001tmj.3,p.A775V|ENST00000490090,p.A775V|ENST00000280758,p.A775V|uc001tml.1,p.A312V	protein_coding	uc001tml.1	nonsynonymous SNV	exon8	c.C935T	p.A312V	SLEEILAEGTDLAETAPPPLCASRN	SLEEILAEGTDLVETAPPPLCASRN	4.0	7.0	-	-	3903_12:108012027-108012027 C>T_SLEEILAEGTDLVETAPPPLCASRN	0.0
17:17106187-17106187 G>A	1.0	4000	MELANOMA	-	-	-	-	PLD6	NM_178836,p.P218L|uc002gqz.3,p.P218L|ENST00000321560,p.P218L	protein_coding	uc002gqz.3	nonsynonymous SNV	exon2	c.C653T	p.P218L	WEQFNPTKYTFFPPKKSHGSCAPPV	WEQFNPTKYTFFLPKKSHGSCAPPV	6.0	9.0	-	-	4000_17:17106187-17106187 G>A_WEQFNPTKYTFFLPKKSHGSCAPPV	0.0
12:8374542-8374542 A>T	0.0	4335	COLORECTAL	-	-	-	-	FAM90A1	uc001quh.2,p.L424H|uc001qui.2,p.L424H|ENST00000307435,p.L424H|NM_018088,p.L424H|ENST00000538603,p.L424H	protein_coding	uc001qui.2	nonsynonymous SNV	exon7	c.T1271A	p.L424H	PSFHSPEKPGAFLAQSPHVSEKSEG	PSFHSPEKPGAFHAQSPHVSEKSEG	8.0	8.0	-	-	4335_12:8374542-8374542 A>T_PSFHSPEKPGAFHAQSPHVSEKSEG	0.0
17:67190591-67190591 C>T	0.0	2591	MELANOMA	-	-	-	-	ABCA10	ENST00000416101,p.G427E|uc010dfb.1,p.G28E|ENST00000523419,p.G427E|ENST00000269081,p.G427E|NM_080282,p.G427E|uc010dfa.1,p.G427E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dfb.1	nonsynonymous SNV	exon5	c.G83A	p.G28E	FDIYEGQITAILGHNGAGKSTLLNI	FDIYEGQITAILEHNGAGKSTLLNI	2.0	8.0	-	-	2591_17:67190591-67190591 C>T_FDIYEGQITAILEHNGAGKSTLLNI	0.0
17:37263770-37263770 A>T	0.0	4329	COLORECTAL	-	-	-	-	PLXDC1	uc002hrg.2,p.F201I|ENST00000578390,p.F201I|ENST00000444911,p.F161I|ENST00000539608,p.F128I|ENST00000394316,p.F201I|ENST00000315392,p.F201I|NM_020405,p.F201I|ENST00000441877,p.F128I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hrg.2	nonsynonymous SNV	exon6	c.T601A	p.F201I	NSTVVYFDNGTVFVVQWDHVYLQGW	NSTVVYFDNGTVIVVQWDHVYLQGW	8.0	2.0	-	-	4329_17:37263770-37263770 A>T_NSTVVYFDNGTVIVVQWDHVYLQGW	0.0
1:156640937-156640937 C>T	1.0	2591	MELANOMA	-	-	-	-	NES	NM_006617,p.E1015K|uc001fpq.3,p.E1015K|ENST00000368223,p.E1015K	protein_coding	uc001fpq.3	nonsynonymous SNV	exon4	c.G3043A	p.E1015K	TEEVWIPGEGHPESPEPKEQRGLVE	TEEVWIPGEGHPKSPEPKEQRGLVE	10.0	8.0	-	-	2591_1:156640937-156640937 C>T_TEEVWIPGEGHPKSPEPKEQRGLVE	0.0
5:64037022-64037022 G>A	1.0	4110	BILE DUCT	-	-	-	-	SREK1IP1	ENST00000513458,p.H23Y|uc003jtk.3,p.H23Y|NM_173829,p.H23Y	retained_intron, protein_coding, processed_transcript	uc003jtk.3	nonsynonymous SNV	exon3	c.C67T	p.H23Y	VRAGCKKCGYPGHLTFECRNFLRVD	VRAGCKKCGYPGYLTFECRNFLRVD	9.0	10.0	-	-	4110_5:64037022-64037022 G>A_VRAGCKKCGYPGYLTFECRNFLRVD	0.0
12:4479657-4479657 G>A	0.0	4298	COLORECTAL	-	-	-	-	FGF23	ENST00000237837,p.P203L|NM_020638,p.P203L|uc001qmq.1,p.P203L	protein_coding	uc001qmq.1	nonsynonymous SNV	exon3	c.C608T	p.P203L	NVLKPRARMTPAPASCSQELPSAED	NVLKPRARMTPALASCSQELPSAED	3.0	9.0	-	-	4298_12:4479657-4479657 G>A_NVLKPRARMTPALASCSQELPSAED	0.0
10:114920450-114920450 G>C	1.0	4071	COLORECTAL	-	-	ID=COSM1345851;OCCURENCE=1(large_intestine)	1	TCF7L2	uc010qrr.2,p.R396T|NM_001146274,p.R464T|ENST00000545257,p.R481T|uc001lae.4,p.R464T|ENST00000543371,p.R464T|uc021pyk.1,p.R446T|uc010qrt.2,p.R352T|uc021pyn.1,p.R469T|uc010qrl.2,p.R441T|NM_001198526,p.R441T	protein_coding, processed_transcript, nonsense_mediated_decay	uc021pyn.1	nonsynonymous SNV	exon13	c.G1406C	p.R469T	GLDRQTLWCKPCRRKKKCVRYIQGE	GLDRQTLWCKPCTRKKKCVRYIQGE	8.0	7.0	-	-	4071_10:114920450-114920450 G>C_GLDRQTLWCKPCTRKKKCVRYIQGE	0.0
X:2408423-2408423 T>C	0.0	4186	BREAST	-	-	ID=COSM1119429;OCCURENCE=1(endometrium)	-	ZBED1	uc022brw.1,p.K113R|ENST00000461691,p.K113R|ENST00000381218,p.K113R|NM_004729,p.K113R|uc004cqh.2,p.K113R|uc004cqg.2,p.K113R|NM_001171136,p.K113R|uc022brx.1,p.K113R|ENST00000381223,p.K113R|NM_001171135,p.K113R|ENST00000381222,p.K113R	protein_coding	uc022brx.1	nonsynonymous SNV	exon1	c.A338G	p.K113R	SSQQPGQDALAVKAGHGYDSKKQQE	SSQQPGQDALAVRAGHGYDSKKQQE	7.0	9.0	-	-	4186_X:2408423-2408423 T>C_SSQQPGQDALAVRAGHGYDSKKQQE	0.0
5:140788781-140788781 C>T	0.0	3903	MELANOMA	-	-	-	-	PCDHGB6	NM_018926,p.L338F|uc003lki.1,p.L338F|NM_032100,p.L338F|uc003lkj.2,p.L338F|ENST00000520790,p.L338F	protein_coding	uc003lkj.2	nonsynonymous SNV	exon1	c.C1012T	p.L338F	GLSTQCKVIIEILDENDNSPEIIIT	GLSTQCKVIIEIFDENDNSPEIIIT	4.0	5.0	-	-	3903_5:140788781-140788781 C>T_GLSTQCKVIIEIFDENDNSPEIIIT	0.0
12:45742378-45742379 CT>-	1.0	4213	COLORECTAL	-	-	-	-	ANO6	uc010sld.1,p.N237fs|uc010slf.2,p.N258fs|ENST00000423947,p.N258fs|ENST00000435642,p.N237fs|NM_001142679,p.N237fs|uc010slg.2,p.N219fs|ENST00000320560,p.N237fs|NM_001142678,p.N219fs|ENST00000441606,p.N219fs|NM_001025356,p.N237fs|uc001roo.3,p.N237fs|ENST00000425752,p.N237fs|NM_001204803,p.N258fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010slg.2	frameshift deletion	exon6	c.657_658del	p.N219fs	NNVSKFGINRLVNSGIYKAAFPLHD	NNVSKFGINRLVNWDLQGSFPTP	9.0	4.0	-	-	4213_12:45742378-45742379 CT>-_NNVSKFGINRLVNWDLQGSFPTP	0.0
13:39587525-39587525 G>A	1.0	3713	MELANOMA	-	-	-	-	PROSER1	ENST00000350125,p.P600S|NM_025138,p.P622S|uc001uwy.4,p.P622S|ENST00000352251,p.P622S	protein_coding, processed_transcript	uc001uwy.4	nonsynonymous SNV	exon11	c.C1864T	p.P622S	EPTSPTPSAFKGPSHSGNPSHGTLG	EPTSPTPSAFKGSSHSGNPSHGTLG	7.0	10.0	-	-	3713_13:39587525-39587525 G>A_EPTSPTPSAFKGSSHSGNPSHGTLG	0.0
18:59828574-59828574 A>G	1.0	3713	MELANOMA	-	-	-	-	PIGN	ENST00000588571,p.F5L|ENST00000587134,p.F5L|ENST00000589339,p.F5L|NM_012327,p.F5L|ENST00000585344,p.F5L|NM_176787,p.F5L|ENST00000585926,p.F5L|ENST00000400334,p.F5L|uc021ulb.1,p.F5L|ENST00000357637,p.F5L|ENST00000589720,p.F5L|ENST00000585923,p.F5L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ulb.1	nonsynonymous SNV	exon1	c.T13C	p.F5L	MLLFFTLGLLIHFVFFA	MLLFLTLGLLIHFVFFA	7.0	5.0	-	-	3713_18:59828574-59828574 A>G_MLLFLTLGLLIHFVFFA	0.0
1:218609465-218609465 C>T	0.0	4316	COLORECTAL	-	-	-	-	TGFB2	ENST00000366930,p.A303V|uc001hlm.3,p.A303V|NM_003238,p.A303V|NM_001135599,p.A331V|uc001hln.3,p.A331V|ENST00000366929,p.A331V	protein_coding, processed_transcript	uc001hln.3	nonsynonymous SNV	exon6	c.C992T	p.A331V	LESQQTNRRKKRALDAAYCFRNVQD	LESQQTNRRKKRVLDAAYCFRNVQD	2.0	8.0	-	-	4316_1:218609465-218609465 C>T_LESQQTNRRKKRVLDAAYCFRNVQD	0.0
8:48647912-48647912 T>C	1.0	4326	BREAST	-	-	-	-	SPIDR	uc003xqd.3,p.L883S|uc011ldf.2,p.L388S|uc003xqe.3,p.L358S|NM_001080394,p.L883S|ENST00000297423,p.L883S|uc011ldg.2,p.L373S|ENST00000517693,p.L358S|uc011ldc.2,p.L813S|NM_001282916,p.L813S|ENST00000541342,p.L813S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ldg.2	nonsynonymous SNV	exon10	c.T1118C	p.L373S	EVKSVLGKEVGLLNCFVQSVTAHPT	EVKSVLGKEVGLSNCFVQSVTAHPT	10.0	1.0	-	-	4326_8:48647912-48647912 T>C_EVKSVLGKEVGLSNCFVQSVTAHPT	0.0
7:126173719-126173719 G>A	0.0	3903	MELANOMA	-	-	-	-	GRM8	uc003vlr.2,p.P573S|NM_000845,p.P573S|uc003vlt.2,p.P573S|ENST00000358373,p.P573S|ENST00000339582,p.P573S|ENST00000472701,p.P573S|ENST00000444921,p.P573S|NM_001127323,p.P573S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003vlt.2	nonsynonymous SNV	exon9	c.C1717T	p.P573S	RPNMNRTGCQLIPIIKLEWHSPWAV	RPNMNRTGCQLISIIKLEWHSPWAV	1.0	5.0	-	-	3903_7:126173719-126173719 G>A_RPNMNRTGCQLISIIKLEWHSPWAV	0.0
16:83999125-83999125 G>A	1.0	3775	CERVICAL	-	-	-	-	OSGIN1	uc002fhb.4,p.R316H|uc002fhc.3,p.R316H|ENST00000343939,p.R399H|ENST00000361711,p.R316H|NM_182981,p.R316H|uc002fha.4,p.R399H|ENST00000393306,p.R316H	protein_coding, processed_transcript	uc002fhc.3	nonsynonymous SNV	exon6	c.G947A	p.R316H	ARHYNIPVIHAFRRAVDDPGLVFNQ	ARHYNIPVIHAFHRAVDDPGLVFNQ	4.0	5.0	-	-	3775_16:83999125-83999125 G>A_ARHYNIPVIHAFHRAVDDPGLVFNQ	0.0
14:76259262-76259262 C>T	1.0	3879	MELANOMA	-	-	-	-	TTLL5	uc001xsa.3,p.S71L|uc010ask.2,p.S1012L|ENST00000557636,p.S1012L	retained_intron, protein_coding, processed_transcript	uc010ask.2	nonsynonymous SNV	exon28	c.C3035T	p.S1012L	KLSRPSSAKAAGSCYLNKHHSGIAK	KLSRPSSAKAAGLCYLNKHHSGIAK	7.0	9.0	-	-	3879_14:76259262-76259262 C>T_KLSRPSSAKAAGLCYLNKHHSGIAK	0.0
6:100395683-100395683 T>G	0.0	4095	COLORECTAL	-	-	-	-	MCHR2	NM_001040179,p.N116T|uc003pqi.1,p.N116T|NM_032503,p.N116T|ENST00000281806,p.N116T|uc003pqh.1,p.N116T|ENST00000369212,p.N116T|ENST00000445970,p.N116T	protein_coding	uc003pqi.1	nonsynonymous SNV	exon3	c.A347C	p.N116T	PLCTIITSLDTCNQFACSAIMTVMS	PLCTIITSLDTCTQFACSAIMTVMS	2.0	10.0	-	-	4095_6:100395683-100395683 T>G_PLCTIITSLDTCTQFACSAIMTVMS	0.0
22:24836819-24836819 T>G	0.0	4284	COLORECTAL	-	-	-	-	ADORA2A	uc010guq.3,p.F201V|ENST00000337539,p.F201V|NM_001278497,p.F201V|NM_001278499,p.F201V|uc010gup.3,p.F201V|uc011ajs.2,p.F62V|NM_001278500,p.F201V|uc003aab.3,p.F201V|ENST00000444262,p.F201V|uc002zzx.3,p.F201V|NM_001278498,p.F201V|uc002zzy.4,p.F201V|NM_000675,p.F201V	protein_coding, processed_transcript	uc011ajs.2	nonsynonymous SNV	exon2	c.T184G	p.F62V	PLLLMLGVYLRIFLAARRQLKQMES	PLLLMLGVYLRIVLAARRQLKQMES	4.0	6.0	-	-	4284_22:24836819-24836819 T>G_PLLLMLGVYLRIVLAARRQLKQMES	0.0
14:23842509-23842509 C>T	0.0	4110	BILE DUCT	-	-	-	-	IL25	NM_172314,p.P45L|uc001wjr.3,p.P61L|uc001wjq.3,p.P45L|ENST00000329715,p.P61L|ENST00000397242,p.P45L|NM_022789,p.P61L	protein_coding	uc001wjr.3	nonsynonymous SNV	exon1	c.C182T	p.P61L	EELLRWSTVPVPPLEPARPNRHPES	EELLRWSTVPVPLLEPARPNRHPES	1.0	6.0	-	-	4110_14:23842509-23842509 C>T_EELLRWSTVPVPLLEPARPNRHPES	0.0
7:56065082-56065082 G>A	1.0	4078	GASTRIC	-	-	-	-	GBAS	NM_001483,p.E246K|uc003trf.2,p.E207K|ENST00000446778,p.E207K|NM_001202469,p.E207K|ENST00000322090,p.E246K|uc003tre.2,p.E246K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003trf.2	nonsynonymous SNV	exon7	c.G619A	p.E207K	HHLWAYRDLQTREDIRNAAWHKHGW	HHLWAYRDLQTRKDIRNAAWHKHGW	8.0	3.0	CD8	-	4078_7:56065082-56065082 G>A_HHLWAYRDLQTRKDIRNAAWHKHGW	1.0
1:118476110-118476110 G>T	0.0	4155	MELANOMA	-	-	-	-	WDR3	ENST00000349139,p.E56D|uc010oxe.1,p.E56D|NM_006784,p.E56D	protein_coding, processed_transcript	uc010oxe.1	nonsynonymous SNV	exon2	c.G168T	p.E56D	CEHVFIWDLRKGEKILILQGLKQEV	CEHVFIWDLRKGDKILILQGLKQEV	7.0	8.0	-	-	4155_1:118476110-118476110 G>T_CEHVFIWDLRKGDKILILQGLKQEV	0.0
20:16359621-16359621 A>G	1.0	3784	MELANOMA	-	-	-	-	KIF16B	uc002wpf.1,p.L391P|uc010gci.2,p.L1009P|ENST00000355755,p.L1009P|uc002wpe.1,p.L391P|uc002wpg.2,p.L1009P|NM_001199865,p.L1009P|NM_001199866,p.L1009P|NM_024704,p.L1009P|uc010gcj.2,p.L1020P|uc010gch.2,p.L1009P|ENST00000378003,p.L235P|ENST00000354981,p.L1009P|ENST00000408042,p.L1009P	protein_coding	uc010gcj.2	nonsynonymous SNV	exon20	c.T3059C	p.L1020P	REKQQREALERALARLERRHSALQR	REKQQREALERAPARLERRHSALQR	7.0	7.0	CD8	-	3784_20:16359621-16359621 A>G_REKQQREALERAPARLERRHSALQR	1.0
11:59410471-59410473 AGA>-	1.0	4298	COLORECTAL	-	-	-	-	PATL1	NM_152716,p.643_644del|uc009yms.1,p.613_614del|ENST00000300146,p.643_644del|uc001noe.4,p.643_644del	retained_intron, protein_coding	uc009yms.1	nonframeshift deletion	exon15	c.1839_1841del	p.613_614del	EVLPCLLSPFSLLLYHLPSVSITSL	EVLPCLLSPFSLLYHLPSVSITSLL	8.0	6.0	-	-	4298_11:59410471-59410473 AGA>-_EVLPCLLSPFSLLYHLPSVSITSLL	0.0
13:100617811-100617811 G>T	1.0	4110	BILE DUCT	-	-	-	-	ZIC5	NM_033132,p.D604E|uc001vom.1,p.D604E|ENST00000267294,p.D604E	protein_coding	uc001vom.1	nonsynonymous SNV	exon2	c.C1812A	p.D604E	GTPVGAPLSPVLDPARSHSSTLSPQ	GTPVGAPLSPVLEPARSHSSTLSPQ	3.0	9.0	-	-	4110_13:100617811-100617811 G>T_GTPVGAPLSPVLEPARSHSSTLSPQ	0.0
1:146743910-146743910 C>T	1.0	4155	MELANOMA	-	-	-	-	CHD1L	uc009wji.4,p.P132L|ENST00000369258,p.P413L|uc001epn.5,p.P300L|NM_001256337,p.P132L|ENST00000361293,p.P132L|NM_001256336,p.P313L|uc010ozp.3,p.P132L|uc031pok.1,p.P313L|NM_024568,p.P300L|ENST00000369259,p.P209L|NM_001256338,p.P209L|uc001epo.5,p.P209L|NM_004284,p.P413L|uc001epm.5,p.P413L	protein_coding, processed_transcript	uc031pok.1	nonsynonymous SNV	exon11	c.C938T	p.P313L	ERHLAIKNFGQQPIFVFLLSTRAGG	ERHLAIKNFGQQLIFVFLLSTRAGG	9.0	5.0	-	-	4155_1:146743910-146743910 C>T_ERHLAIKNFGQQLIFVFLLSTRAGG	0.0
20:37547185-37547185 C>T	0.0	4275	COLORECTAL	-	-	-	-	PPP1R16B	uc002xje.3,p.P527L|ENST00000299824,p.P527L|NM_015568,p.P527L|ENST00000373331,p.P485L|uc010ggc.3,p.P485L|NM_001172735,p.P485L	protein_coding, processed_transcript	uc010ggc.3	nonsynonymous SNV	exon10	c.C1454T	p.P485L	EGKAPLIGGRTSPYSSNGTSVYYTV	EGKAPLIGGRTSLYSSNGTSVYYTV	5.0	3.0	-	-	4275_20:37547185-37547185 C>T_EGKAPLIGGRTSLYSSNGTSVYYTV	0.0
8:120814162-120814162 C>G	0.0	4129	NSCLC	-	-	-	-	TAF2	uc003you.3,p.E222Q|NM_003184,p.E222Q|ENST00000378164,p.E222Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003you.3	nonsynonymous SNV	exon6	c.G664C	p.E222Q	AAMVAVSNGDLVETVYTHDMRKKTF	AAMVAVSNGDLVQTVYTHDMRKKTF	10.0	9.0	-	-	4129_8:120814162-120814162 C>G_AAMVAVSNGDLVQTVYTHDMRKKTF	0.0
20:30371683-30371683 C>T	1.0	3713	MELANOMA	-	-	-	-	TPX2	uc002wwp.1,p.H458Y|ENST00000300403,p.H458Y|uc010gdv.1,p.H494Y|ENST00000340513,p.H494Y|NM_012112,p.H458Y	protein_coding	uc010gdv.1	nonsynonymous SNV	exon13	c.C1480T	p.H494Y	SKKKTEDEHFEFHSRPCPTKILEDV	SKKKTEDEHFEFYSRPCPTKILEDV	7.0	6.0	CD8	-	3713_20:30371683-30371683 C>T_SKKKTEDEHFEFYSRPCPTKILEDV	1.0
8:87568417-87568417 C>T	1.0	3713	MELANOMA	-	-	-	-	CPNE3	ENST00000198765,p.P448S|NM_003909,p.P448S|uc003ydw.1,p.P164S|ENST00000521271,p.P448S|uc003ydv.2,p.P448S	retained_intron, protein_coding	uc003ydw.1	nonsynonymous SNV	exon6	c.C490T	p.P164S	ETRQAIVNASRLPMSIIIVGVGGAD	ETRQAIVNASRLSMSIIIVGVGGAD	8.0	2.0	-	-	3713_8:87568417-87568417 C>T_ETRQAIVNASRLSMSIIIVGVGGAD	0.0
1:228582879-228582879 C>A	1.0	4126	NSCLC	-	-	-	-	TRIM11	uc010pvx.2,p.G311W|uc001hss.3,p.G312W|ENST00000493030,p.G187W|ENST00000284551,p.G312W|NM_145214,p.G312W	protein_coding, processed_transcript	uc010pvx.2	nonsynonymous SNV	exon6	c.G931T	p.G311W	LILSEDRRSVQRGDLRQALPDSPER	LILSEDRRSVQRWDLRQALPDSPER	9.0	10.0	CD8	-	4126_1:228582879-228582879 C>A_LILSEDRRSVQRWDLRQALPDSPER	1.0
3:49044919-49044919 C>T	1.0	3879	MELANOMA	-	-	-	-	WDR6	ENST00000452875,p.L19F|uc011bby.1,p.L49F|uc003cvj.2,p.L49F|ENST00000488572,p.L19F|ENST00000438660,p.L19F|ENST00000395474,p.L49F|NM_018031,p.L49F|uc011bbx.1,p.L49F|ENST00000415265,p.L19F|ENST00000420783,p.L19F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bby.1	nonsynonymous SNV	exon1	c.C145T	p.L49F	YVWPRATSELILLPVTGLECVGDRL	YVWPRATSELILFPVTGLECVGDRL	6.0	10.0	-	-	3879_3:49044919-49044919 C>T_YVWPRATSELILFPVTGLECVGDRL	0.0
19:12244240-12244240 G>A	1.0	2369	MELANOMA	-	-	-	-	ZNF20	ENST00000334213,p.A254V|NM_001203250,p.A251V|uc002mtg.2,p.A254V|uc002mtf.2,p.A254V|uc002mte.2,p.A219V|uc021upm.1,p.A251V|NM_021143,p.A254V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021upm.1	nonsynonymous SNV	exon4	c.C752T	p.A251V	LPVHERTHTGVNADECKECGNAFSF	LPVHERTHTGVNVDECKECGNAFSF	5.0	10.0	-	-	2369_19:12244240-12244240 G>A_LPVHERTHTGVNVDECKECGNAFSF	0.0
14:61115697-61115697 C>G	1.0	4134	NSCLC	-	-	-	-	SIX1	uc001xfb.4,p.E71Q|ENST00000247182,p.E71Q|NM_005982,p.E71Q	retained_intron, protein_coding	uc001xfb.4	nonsynonymous SNV	exon1	c.G211C	p.E71Q	HRGNFRELYKILESHQFSPHNHPKL	HRGNFRELYKILQSHQFSPHNHPKL	5.0	7.0	-	-	4134_14:61115697-61115697 C>G_HRGNFRELYKILQSHQFSPHNHPKL	0.0
13:99484037-99484037 G>C	1.0	3775	CERVICAL	-	-	-	-	DOCK9	uc010tir.1,p.Q1418E|ENST00000449796,p.Q161E|uc010tio.1,p.Q110E|uc010tip.1,p.Q128E|ENST00000340449,p.Q61E|uc001vnr.2,p.Q61E|ENST00000376460,p.Q1417E|uc001vnw.2,p.Q1417E|uc001vnt.2,p.Q1418E|uc021rlw.1,p.Q1417E|uc010tin.1,p.Q61E|ENST00000339416,p.Q1418E|uc010tiq.1,p.Q396E	protein_coding, processed_transcript	uc021rlw.1	nonsynonymous SNV	exon40	c.C4249G	p.Q1417E	DTLSLFTLAFKNQLLADHGHNPLMK	DTLSLFTLAFKNELLADHGHNPLMK	9.0	5.0	-	-	3775_13:99484037-99484037 G>C_DTLSLFTLAFKNELLADHGHNPLMK	0.0
16:9185938-9185938 C>G	1.0	4000	MELANOMA	-	-	-	-	C16orf72	NM_014117,p.Q13E|uc002czm.3,p.Q13E|ENST00000327827,p.Q13E	protein_coding	uc002czm.3	nonsynonymous SNV	exon1	c.C37G	p.Q13E	MEERKEEGEAEIQEHGPEHWFSKWE	MEERKEEGEAEIEEHGPEHWFSKWE	7.0	4.0	-	-	4000_16:9185938-9185938 C>G_MEERKEEGEAEIEEHGPEHWFSKWE	0.0
2:32756504-32756504 A>T	1.0	4196	COLORECTAL	-	-	-	2	BIRC6	ENST00000421745,p.E4059D|NM_016252,p.E4059D|uc010ezu.3,p.E4059D	retained_intron, protein_coding, nonsense_mediated_decay	uc010ezu.3	nonsynonymous SNV	exon61	c.A12177T	p.E4059D	TPGDECMDGILDESLLETCPIQSPL	TPGDECMDGILDDSLLETCPIQSPL	10.0	6.0	-	-	4196_2:32756504-32756504 A>T_TPGDECMDGILDDSLLETCPIQSPL	0.0
1:196918731-196918731 C>T	0.0	4235	COLORECTAL	-	-	-	-	CFHR2	ENST00000367415,p.R69C|ENST00000367421,p.R69C|NM_005666,p.R69C|uc001gtq.1,p.R69C	protein_coding, processed_transcript	uc001gtq.1	nonsynonymous SNV	exon2	c.C205T	p.R69C	YNFVSPSKSFWTRITCAEEGWSPTP	YNFVSPSKSFWTCITCAEEGWSPTP	1.0	5.0	-	-	4235_1:196918731-196918731 C>T_YNFVSPSKSFWTCITCAEEGWSPTP	0.0
17:76198784-76198784 C>T	1.0	3713	MELANOMA	-	-	-	-	AFMID	ENST00000588800,p.A52V|uc002jvb.3,p.A52V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002jvb.3	nonsynonymous SNV	exon3	c.C155T	p.A52V	EALRTYSQIGIEALPFFLFFHGGYW	EALRTYSQIGIEVLPFFLFFHGGYW	9.0	6.0	CD8	-	3713_17:76198784-76198784 C>T_EALRTYSQIGIEVLPFFLFFHGGYW	1.0
3:52550201-52550201 G>A	0.0	4155	MELANOMA	-	-	-	-	STAB1	NM_015136,p.G1364E|ENST00000321725,p.G1364E|uc003dej.3,p.G1364E	retained_intron, protein_coding	uc003dej.3	nonsynonymous SNV	exon38	c.G4091A	p.G1364E	GSGECHCHEGFHGTACEVCELGRYG	GSGECHCHEGFHETACEVCELGRYG	9.0	4.0	-	-	4155_3:52550201-52550201 G>A_GSGECHCHEGFHETACEVCELGRYG	0.0
17:73895350-73895350 G>T	1.0	3919	MELANOMA	-	-	-	-	MRPL38	uc010wso.1,p.R299S|NM_032478,p.R299S|ENST00000409963,p.R115S|ENST00000309352,p.R299S	retained_intron, protein_coding, processed_transcript	uc010wso.1	nonsynonymous SNV	exon8	c.C895A	p.R299S	PSPCYQLAQRTFRTFDFYKKHQETM	PSPCYQLAQRTFSTFDFYKKHQETM	5.0	3.0	-	-	3919_17:73895350-73895350 G>T_PSPCYQLAQRTFSTFDFYKKHQETM	0.0
9:96715451-96715451 T>A	0.0	4110	BILE DUCT	-	-	-	-	BARX1	NM_021570,p.Q81L|ENST00000253968,p.Q81L|uc010mrh.3,p.Q81L	protein_coding	uc010mrh.3	nonsynonymous SNV	exon2	c.A242T	p.Q81L	PFHSHLAVLKAEQAAVFKFPLAPLG	PFHSHLAVLKAELAAVFKFPLAPLG	1.0	10.0	-	-	4110_9:96715451-96715451 T>A_PFHSHLAVLKAELAAVFKFPLAPLG	0.0
17:48431105-48431105 C>T	0.0	4235	COLORECTAL	-	-	-	-	XYLT2	ENST00000376550,p.R84C|ENST00000507602,p.R84C|uc002iqo.3,p.R84C|ENST00000017003,p.R84C|NM_022167,p.R84C	retained_intron, protein_coding, nonsense_mediated_decay	uc002iqo.3	nonsynonymous SNV	exon2	c.C250T	p.R84C	GSTGRRHGRWRGRAESPGVPVAKVV	GSTGRRHGRWRGCAESPGVPVAKVV	7.0	10.0	-	-	4235_17:48431105-48431105 C>T_GSTGRRHGRWRGCAESPGVPVAKVV	0.0
3:180324156-180324156 G>T	1.0	4298	COLORECTAL	-	-	-	-	TTC14	uc003fkl.3,p.A349S|ENST00000470669,p.A349S|NM_001288582,p.A349S|NM_133462,p.A349S|uc003fkm.2,p.A349S|uc003fkk.3,p.A349S|ENST00000412756,p.A349S|ENST00000382584,p.A349S|NM_001042601,p.A349S|ENST00000296015,p.A349S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fkm.2	nonsynonymous SNV	exon8	c.G1045T	p.A349S	DKQNVEALVARGALYATKGSLNKAI	DKQNVEALVARGSLYATKGSLNKAI	9.0	9.0	-	-	4298_3:180324156-180324156 G>T_DKQNVEALVARGSLYATKGSLNKAI	0.0
6:89601552-89601552 T>G	1.0	4071	COLORECTAL	-	-	-	-	RNGTT	uc003pmt.2,p.K256T|ENST00000538899,p.K196T|NM_001286426,p.K256T|NM_001286428,p.K196T|ENST00000369485,p.K256T|uc003pmr.2,p.K256T|uc003pms.2,p.K256T|NM_003800,p.K256T|ENST00000265607,p.K256T|uc011dzu.1,p.K196T|ENST00000369475,p.K256T	protein_coding	uc011dzu.1	nonsynonymous SNV	exon6	c.A587C	p.K196T	VTTQPKLGEVQQKCHQFCGWEGSGF	VTTQPKLGEVQQTCHQFCGWEGSGF	6.0	5.0	-	-	4071_6:89601552-89601552 T>G_VTTQPKLGEVQQTCHQFCGWEGSGF	0.0
16:11931910-11931910 G>A	1.0	4155	MELANOMA	-	-	-	-	RSL1D1	ENST00000355674,p.R402C|NM_015659,p.R403C|uc010buv.1,p.R402C|ENST00000542106,p.R183C|ENST00000571133,p.R403C|uc002dbp.1,p.R403C|uc010uyw.1,p.R183C	retained_intron, protein_coding, nonsense_mediated_decay	uc010uyw.1	nonsynonymous SNV	exon8	c.C547T	p.R183C	KSPAKSPNPSTPRGKKRKALPASET	KSPAKSPNPSTPCGKKRKALPASET	10.0	7.0	CD8	-	4155_16:11931910-11931910 G>A_KSPAKSPNPSTPCGKKRKALPASET	1.0
11:72399554-72399554 A>G	1.0	4301	MELANOMA	-	-	-	-	ARAP1	ENST00000393609,p.I1339T|NM_001040118,p.I1339T|uc001oss.3,p.I1094T|uc001osr.3,p.I1099T|uc001osu.3,p.I1339T|ENST00000334211,p.I1094T|NM_015242,p.I1094T|ENST00000393605,p.I1099T	retained_intron, protein_coding, processed_transcript	uc001osu.3	nonsynonymous SNV	exon31	c.T4016C	p.I1339T	PETSHRPEKEWPIKSLKVYLGVKKK	PETSHRPEKEWPTKSLKVYLGVKKK	9.0	9.0	-	-	4301_11:72399554-72399554 A>G_PETSHRPEKEWPTKSLKVYLGVKKK	0.0
19:38573527-38573527 A>C	1.0	4345	COLORECTAL	-	-	-	-	SIPA1L3	ENST00000222345,p.N441T|NM_015073,p.N441T|uc002ohk.3,p.N441T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ohk.3	nonsynonymous SNV	exon3	c.A1322C	p.N441T	HFRNEIGGECERNVSFSRASVGSPS	HFRNEIGGECERTVSFSRASVGSPS	7.0	5.0	-	-	4345_19:38573527-38573527 A>C_HFRNEIGGECERTVSFSRASVGSPS	0.0
14:20779867-20779867 G>A	1.0	3678	MELANOMA	-	-	-	1	CCNB1IP1	ENST00000398169,p.R226W|ENST00000358932,p.R226W|ENST00000398160,p.R226W|uc001vwx.4,p.R226W|NM_182852,p.R226W|ENST00000437553,p.R226W|uc001vwv.4,p.R226W|NM_182849,p.R226W|uc001vwz.4,p.R226W|uc021rnp.2,p.R226W|NM_021178,p.R226W|ENST00000398163,p.R226W|ENST00000353689,p.R226W|uc001vwy.4,p.R226W	protein_coding, processed_transcript, nonsense_mediated_decay	uc021rnp.2	nonsynonymous SNV	exon8	c.C676T	p.R226W	SKFPLDNTPVRNRGDGDGDFQFRPF	SKFPLDNTPVRNWGDGDGDFQFRPF	9.0	6.0	-	-	3678_14:20779867-20779867 G>A_SKFPLDNTPVRNWGDGDGDFQFRPF	0.0
1:186648506-186648506 C>G	0.0	4158	COLORECTAL	-	-	-	-	PTGS2	NM_000963,p.Q39H|uc001gsb.3,p.Q39H|ENST00000367468,p.Q39H|ENST00000559627,p.Q39H	protein_coding, processed_transcript, nonsense_mediated_decay	uc001gsb.3	nonsynonymous SNV	exon2	c.G117C	p.Q39H	QNRGVCMSVGFDQYKCDCTRTGFYG	QNRGVCMSVGFDHYKCDCTRTGFYG	4.0	4.0	-	-	4158_1:186648506-186648506 C>G_QNRGVCMSVGFDHYKCDCTRTGFYG	0.0
11:111631655-111631655 G>C	0.0	3775	CERVICAL	-	-	-	-	PPP2R1B	uc010rwi.1,p.L79V|ENST00000341980,p.L143V|ENST00000311129,p.L143V|uc001plw.1,p.L143V|NM_181700,p.L79V|ENST00000426998,p.L79V|NM_181699,p.L143V|ENST00000527614,p.L143V|uc010rwk.1,p.L143V|NM_002716,p.L143V|uc001plx.1,p.L143V|NM_001177562,p.L143V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rwk.1	nonsynonymous SNV	exon4	c.C427G	p.L143V	HTPVALEAYFVPLVKRLASGDWFTS	HTPVALEAYFVPVVKRLASGDWFTS	6.0	9.0	-	-	3775_11:111631655-111631655 G>C_HTPVALEAYFVPVVKRLASGDWFTS	0.0
4:114277816-114277816 T>-	0.0	4317	COLORECTAL	-	-	-	-	ANK2	ENST00000357077,p.L2681fs|uc003ibe.4,p.L2681fs|uc011cgb.1,p.L2696fs|ENST00000264366,p.L2648fs|NM_001148,p.L2681fs	retained_intron, protein_coding, processed_transcript	uc011cgb.1	frameshift deletion	exon39	c.8087delT	p.L2696fs	ELAQLKKGADSGLLPEPVIRVQPPS	ELAQLKKGADSGLYQNQ	6.0	7.0	-	-	4317_4:114277816-114277816 T>-_ELAQLKKGADSGLYQNQ	0.0
11:123810688-123810688 G>T	0.0	4326	BREAST	-	-	-	-	OR4D5	uc001pzk.1,p.R122L|ENST00000307033,p.R122L|NM_001001965,p.R122L	protein_coding	uc001pzk.1	nonsynonymous SNV	exon1	c.G365T	p.R122L	IKIFLLTVMAYDRYIAISQPLHYTL	IKIFLLTVMAYDLYIAISQPLHYTL	1.0	5.0	-	-	4326_11:123810688-123810688 G>T_IKIFLLTVMAYDLYIAISQPLHYTL	0.0
1:225459731-225459731 C>T	0.0	2359	MELANOMA	-	-	-	-	DNAH14	uc001how.2,p.P2593S|ENST00000430092,p.P2593S|NM_001373,p.P2593S|ENST00000439375,p.P2593S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001how.2	nonsynonymous SNV	exon51	c.C7777T	p.P2593S	IYHQVRQNMLPTPTKCHYMFNLRDM	IYHQVRQNMLPTSTKCHYMFNLRDM	8.0	2.0	-	-	2359_1:225459731-225459731 C>T_IYHQVRQNMLPTSTKCHYMFNLRDM	0.0
10:61956379-61956379 C>T	1.0	3466	MELANOMA	-	-	-	-	ANK3	uc001jkz.4,p.G559E|ENST00000503366,p.G548E|uc001jlb.1,p.G94E|ENST00000280772,p.G565E|NM_001204403,p.G559E|uc010qih.2,p.G548E|uc001jky.3,p.G565E|NM_020987,p.G565E|ENST00000373827,p.G559E|NM_001204404,p.G548E|uc001jlc.1,p.G226E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qih.2	nonsynonymous SNV	exon15	c.G1643A	p.G548E	DHGASLSITTKKGFTPLHVAAKYGK	DHGASLSITTKKEFTPLHVAAKYGK	5.0	4.0	-	-	3466_10:61956379-61956379 C>T_DHGASLSITTKKEFTPLHVAAKYGK	0.0
9:80863242-80863242 C>T	1.0	3466	MELANOMA	-	-	-	-	CEP78	uc004aky.4,p.L310F|NM_032171,p.L310F|ENST00000376598,p.L310F|ENST00000277082,p.L310F|uc011lsp.1,p.L223F|uc010mpp.3,p.L310F|ENST00000424347,p.L310F|ENST00000376597,p.L310F|uc004akx.2,p.L310F|ENST00000415759,p.L310F|NM_001098802,p.L310F	retained_intron, protein_coding, processed_transcript	uc011lsp.1	nonsynonymous SNV	exon7	c.C667T	p.L223F	DHSMMKAVIKKVLQNGRSAKSEYQW	DHSMMKAVIKKVFQNGRSAKSEYQW	6.0	9.0	-	-	3466_9:80863242-80863242 C>T_DHSMMKAVIKKVFQNGRSAKSEYQW	0.0
2:219029171-219029171 C>A	0.0	4126	NSCLC	-	-	-	-	CXCR1	NM_000634,p.W255L|uc002vhc.3,p.W255L|uc021vwq.1,p.W255L|ENST00000295683,p.W255L	protein_coding	uc021vwq.1	nonsynonymous SNV	exon1	c.G764T	p.W255L	VIFAVVLIFLLCWLPYNLVLLADTL	VIFAVVLIFLLCLLPYNLVLLADTL	3.0	6.0	-	-	4126_2:219029171-219029171 C>A_VIFAVVLIFLLCLLPYNLVLLADTL	0.0
2:144899585-144899585 T>A	0.0	4298	COLORECTAL	-	-	ID=COSM570044;OCCURENCE=1(lung)	-	GTDC1	NM_001284233,p.N129Y|uc002tvp.3,p.N129Y|NM_001006636,p.N129Y|uc021vqg.1,p.N129Y|ENST00000241391,p.N129Y|ENST00000392867,p.N129Y|uc002tvr.3,p.N129Y|ENST00000392871,p.N129Y|uc002tvs.3,p.N97Y|uc021vqf.1,p.N129Y|ENST00000392869,p.N129Y|ENST00000542155,p.N129Y|NM_024659,p.N129Y|NM_001284238,p.N97Y|uc002tvo.3,p.N129Y|ENST00000437114,p.N129Y|ENST00000409214,p.N129Y|NM_001284235,p.N129Y|ENST00000344850,p.N129Y|NM_001164629,p.N129Y|uc010fnn.3,p.N129Y|uc002tvt.2,p.N129Y|ENST00000409298,p.N129Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vqg.1	nonsynonymous SNV	exon8	c.A385T	p.N129Y	LVADVVVFNSVFNMESFLTSMGKFM	LVADVVVFNSVFYMESFLTSMGKFM	7.0	4.0	-	-	4298_2:144899585-144899585 T>A_LVADVVVFNSVFYMESFLTSMGKFM	0.0
2:179578806-179578806 C>T	0.0	3903	MELANOMA	-	-	-	-	TTN	uc002umz.1,p.S4277N|ENST00000589042,p.S8860N|ENST00000342992,p.S7616N|NM_133378,p.S7616N|uc031rqd.1,p.S8543N|NM_001267550,p.S8860N|NM_001256850,p.S8543N|uc021vsy.2,p.S7616N|ENST00000591111,p.S8543N|uc031rqc.1,p.S8860N	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon90	c.G25628A	p.S8543N	TLECTVAGTPELSTKWFKDGKELTS	TLECTVAGTPELNTKWFKDGKELTS	2.0	4.0	-	-	3903_2:179578806-179578806 C>T_TLECTVAGTPELNTKWFKDGKELTS	0.0
11:120744821-120744821 C>T	0.0	4235	COLORECTAL	-	-	-	-	GRIK4	uc009zaw.1,p.A318V|NM_014619,p.A318V|uc009zav.1,p.A318V|uc009zax.1,p.A318V|NM_001282473,p.A318V|NM_001282470,p.A318V|ENST00000438375,p.A318V|ENST00000527524,p.A318V|uc001pxn.2,p.A318V	retained_intron, protein_coding, processed_transcript	uc009zax.1	nonsynonymous SNV	exon8	c.C953T	p.A318V	ALLFDAVYAVVTAVQELNRSQEIGV	ALLFDAVYAVVTVVQELNRSQEIGV	1.0	4.0	-	-	4235_11:120744821-120744821 C>T_ALLFDAVYAVVTVVQELNRSQEIGV	0.0
2:188245276-188245276 C>T	0.0	2591	MELANOMA	-	-	-	-	CALCRL	ENST00000410068,p.G109E|uc010frt.4,p.G109E|ENST00000392370,p.G109E|NM_001271751,p.G109E|ENST00000409998,p.G109E|NM_005795,p.G109E|uc002upv.5,p.G109E	retained_intron, protein_coding, processed_transcript	uc010frt.4	nonsynonymous SNV	exon6	c.G326A	p.G109E	PSEKVTKICDQDGNWFRHPASNRTW	PSEKVTKICDQDENWFRHPASNRTW	1.0	9.0	-	-	2591_2:188245276-188245276 C>T_PSEKVTKICDQDENWFRHPASNRTW	0.0
2:196837053-196837053 G>C	0.0	4326	BREAST	-	-	-	-	DNAH7	NM_018897,p.F657L|ENST00000312428,p.F657L|uc002utj.4,p.F657L	retained_intron, protein_coding, processed_transcript	uc002utj.4	nonsynonymous SNV	exon16	c.C1971G	p.F657L	FSPADMRLNNSVFQWYGRMGEIFEE	FSPADMRLNNSVLQWYGRMGEIFEE	4.0	9.0	-	-	4326_2:196837053-196837053 G>C_FSPADMRLNNSVLQWYGRMGEIFEE	0.0
15:83926220-83926220 C>T	1.0	4129	NSCLC	-	-	-	-	BNC1	NM_001301206,p.A980T|ENST00000345382,p.A987T|uc002bjt.1,p.A987T|NM_001717,p.A987T|uc010uos.1,p.A975T|ENST00000569704,p.A980T	protein_coding	uc010uos.1	nonsynonymous SNV	exon5	c.G2923A	p.A975T	RHSQNPNLHKSLASSPSHLQ	RHSQNPNLHKSLTSSPSHLQ	9.0	4.0	-	-	4129_15:83926220-83926220 C>T_RHSQNPNLHKSLTSSPSHLQ	0.0
12:41386938-41386938 ->GGAAATAT	0.0	4266	COLORECTAL	-	-	-	-	CNTN1	ENST00000551295,p.E660fs|uc031qgz.1,p.E649fs|ENST00000347616,p.E660fs|NM_001843,p.E660fs|ENST00000348761,p.E649fs|uc001rmm.2,p.E660fs|NM_175038,p.E649fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc031qgz.1	frameshift insertion	exon15	c.1947_1948insGGAAATAT	p.E649fs	DWKDAKTDPPIIEGNMEAARAVDLI	DWKDAKTDPPIIEGNMEIWRQQEQWT	3.0	8.0	-	-	4266_12:41386938-41386938 ->GGAAATAT_DWKDAKTDPPIIEGNMEIWRQQEQWT	0.0
2:131258188-131258188 C>T	1.0	4316	COLORECTAL	-	rs4114328	ID=COSN215909;OCCURENCE=1(central_nervous_system)	-	POTEI	ENST00000451531,p.V280I|uc031rpa.1,p.V280I|NM_001277406,p.V280I	protein_coding	uc031rpa.1	nonsynonymous SNV	exon4	c.G838A	p.V280I	KNKHGLTPLLLGVHEQKQQVVKFLI	KNKHGLTPLLLGIHEQKQQVVKFLI	9.0	1.0	-	-	4316_2:131258188-131258188 C>T_KNKHGLTPLLLGIHEQKQQVVKFLI	0.0
10:115410247-115410247 T>G	0.0	4078	GASTRIC	-	-	-	-	NRAP	uc001laj.4,p.I245L|uc001lal.4,p.I245L|ENST00000369360,p.I245L|ENST00000360478,p.I245L|ENST00000369358,p.I245L|uc001lak.4,p.I245L|NM_198060,p.I245L|ENST00000359988,p.I245L|NM_006175,p.I245L|NM_001261463,p.I245L	protein_coding	uc001lal.4	nonsynonymous SNV	exon8	c.A733C	p.I245L	EQQRGKGSFPAMITPAYQIAKRANE	EQQRGKGSFPAMLTPAYQIAKRANE	1.0	3.0	-	-	4078_10:115410247-115410247 T>G_EQQRGKGSFPAMLTPAYQIAKRANE	0.0
5:13753505-13753505 G>T	0.0	4284	COLORECTAL	-	-	-	-	DNAH5	uc003jfd.2,p.A3570D|ENST00000265104,p.A3570D|NM_001369,p.A3570D	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon63	c.C10709A	p.A3570D	GKNLNLSEMLIDAPTISEWNLQGLP	GKNLNLSEMLIDDPTISEWNLQGLP	5.0	4.0	-	-	4284_5:13753505-13753505 G>T_GKNLNLSEMLIDDPTISEWNLQGLP	0.0
4:52926959-52926959 G>A	0.0	2556	MELANOMA	-	-	-	-	SPATA18	uc011bzq.2,p.D69N|NM_145263,p.D69N|ENST00000505320,p.D69N|ENST00000295213,p.D69N|ENST00000505038,p.D69N|NM_001297608,p.D69N|uc003gzk.1,p.D69N|uc003gzl.3,p.D69N|ENST00000419395,p.D69N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bzq.2	nonsynonymous SNV	exon3	c.G205A	p.D69N	ILTAAAQEGGRNDGVETIKSRLLPW	ILTAAAQEGGRNNGVETIKSRLLPW	3.0	2.0	-	-	2556_4:52926959-52926959 G>A_ILTAAAQEGGRNNGVETIKSRLLPW	0.0
19:52376494-52376494 G>A	1.0	4000	MELANOMA	-	-	-	-	ZNF577	ENST00000451628,p.A191V|uc002pxx.4,p.A191V|ENST00000458390,p.A250V|NM_032679,p.A250V|ENST00000301399,p.A250V|uc010yde.2,p.A250V|uc002pxw.3,p.A184V|uc002pxv.3,p.A243V|ENST00000420592,p.A191V|NM_001135590,p.A191V	retained_intron, protein_coding, processed_transcript	uc010yde.2	nonsynonymous SNV	exon7	c.C749T	p.A250V	GEKPYRCSKCGKAFSRKCRLNRHQR	GEKPYRCSKCGKVFSRKCRLNRHQR	8.0	3.0	-	-	4000_19:52376494-52376494 G>A_GEKPYRCSKCGKVFSRKCRLNRHQR	0.0
4:81121289-81121289 C>A	1.0	3713	MELANOMA	-	-	-	-	PRDM8	ENST00000504452,p.Q19K|NM_001099403,p.Q19K|NM_020226,p.Q19K|ENST00000415738,p.Q19K|uc003hmc.4,p.Q19K|uc010ijo.3,p.Q19K|ENST00000515013,p.Q19K|uc003hmb.4,p.Q19K|ENST00000339711,p.Q19K	protein_coding, processed_transcript	uc010ijo.3	nonsynonymous SNV	exon6	c.C55A	p.Q19K	QRGIWDGDAKAVQQCLTDIFTSVYT	QRGIWDGDAKAVKQCLTDIFTSVYT	2.0	9.0	-	-	3713_4:81121289-81121289 C>A_QRGIWDGDAKAVKQCLTDIFTSVYT	0.0
8:52321876-52321876 G>A	0.0	4301	MELANOMA	-	-	-	-	PXDNL	NM_144651,p.P770S|ENST00000356297,p.P770S|ENST00000543296,p.P770S|ENST00000522628,p.P36S|uc003xqu.4,p.P770S	retained_intron, protein_coding, nonsense_mediated_decay	uc003xqu.4	nonsynonymous SNV	exon17	c.C2308T	p.P770S	RDGIRAPRGLGLPVGSRQPLPPPRL	RDGIRAPRGLGLSVGSRQPLPPPRL	4.0	7.0	-	-	4301_8:52321876-52321876 G>A_RDGIRAPRGLGLSVGSRQPLPPPRL	0.0
12:49445505-49445505 G>A	1.0	3998	MELANOMA	-	-	-	1	KMT2D	NM_003482,p.S654F|ENST00000301067,p.S654F|uc001rta.4,p.S654F	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon10	c.C1961T	p.S654F	SPMSPPPEVSRLSPLPVVSRLSPPP	SPMSPPPEVSRLFPLPVVSRLSPPP	10.0	2.0	-	-	3998_12:49445505-49445505 G>A_SPMSPPPEVSRLFPLPVVSRLSPPP	0.0
3:31917962-31917962 C>T	1.0	2556	MELANOMA	-	-	-	-	OSBPL10	NM_001174060,p.R167Q|uc021wuu.1,p.R167Q|uc011axf.2,p.R167Q|ENST00000396556,p.R167Q|NM_017784,p.R167Q|ENST00000438237,p.R167Q	retained_intron, protein_coding, processed_transcript	uc021wuu.1	nonsynonymous SNV	exon3	c.G500A	p.R167Q	DAKEKQFWVTQLRACAKYHMEMNSK	DAKEKQFWVTQLQACAKYHMEMNSK	10.0	7.0	-	-	2556_3:31917962-31917962 C>T_DAKEKQFWVTQLQACAKYHMEMNSK	0.0
2:189909939-189909939 C>T	1.0	3784	MELANOMA	-	-	-	-	COL5A2	NM_000393,p.G1110E|uc002uqk.3,p.G1110E|ENST00000374866,p.G1110E|uc010frx.3,p.G686E	retained_intron, protein_coding	uc010frx.3	nonsynonymous SNV	exon31	c.G2057A	p.G686E	GQRGDPGSRGPIGPPGRAGKRGLPG	GQRGDPGSRGPIEPPGRAGKRGLPG	9.0	8.0	-	-	3784_2:189909939-189909939 C>T_GQRGDPGSRGPIEPPGRAGKRGLPG	0.0
17:37880220-37880220 T>C	1.0	4345	COLORECTAL	-	-	ID=COSM14060;OCCURENCE=4(stomach),1(lung),1(endometrium),2(large_intestine),6(small_intestine),14(breast)	1	ERBB2	ENST00000584450,p.L755S|uc002hso.3,p.L755S|uc010cwa.3,p.L740S|uc010cwb.3,p.L755S|ENST00000406381,p.L725S|uc002hsm.3,p.L725S|ENST00000541774,p.L740S|ENST00000269571,p.L755S|ENST00000584601,p.L725S|ENST00000445658,p.L479S|uc002hsp.3,p.L558S|NM_004448,p.L755S|NM_001289936,p.L740S|NM_001289937,p.L755S|uc010wek.2,p.L479S|NM_001005862,p.L725S|ENST00000540147,p.L725S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wek.2	nonsynonymous SNV	exon13	c.T1436C	p.L479S	GENVKIPVAIKVLRENTSPKANKEI	GENVKIPVAIKVSRENTSPKANKEI	10.0	10.0	-	-	4345_17:37880220-37880220 T>C_GENVKIPVAIKVSRENTSPKANKEI	0.0
9:117936-117936 C>T	1.0	4284	COLORECTAL	-	-	-	-	FOXD4	uc003zfz.4,p.G62R|ENST00000382500,p.G62R|NM_207305,p.G62R	protein_coding	uc003zfz.4	nonsynonymous SNV	exon1	c.G184A	p.G62R	SLQPGLQVARWGGVALPREHIEGGG	SLQPGLQVARWGRVALPREHIEGGG	6.0	9.0	-	-	4284_9:117936-117936 C>T_SLQPGLQVARWGRVALPREHIEGGG	0.0
11:133796904-133796904 G>C	0.0	4316	COLORECTAL	-	-	-	-	IGSF9B	uc001qgy.1,p.L414V|uc031qfh.1,p.L572V|ENST00000533871,p.L572V|NM_001277285,p.L572V|ENST00000321016,p.L572V	protein_coding	uc031qfh.1	nonsynonymous SNV	exon13	c.C1714G	p.L572V	VPPGPSWLLVDTLEPETAYQFSVLA	VPPGPSWLLVDTVEPETAYQFSVLA	3.0	5.0	-	-	4316_11:133796904-133796904 G>C_VPPGPSWLLVDTVEPETAYQFSVLA	0.0
7:117175402-117175402 T>G	0.0	4259	COLORECTAL	-	-	-	-	CFTR	uc003vjd.3,p.L227R|NM_000492,p.L227R|ENST00000426809,p.L197R|ENST00000003084,p.L227R|ENST00000454343,p.L227R	protein_coding, processed_transcript, nonsense_mediated_decay	uc003vjd.3	nonsynonymous SNV	exon6	c.T680G	p.L227R	IWELLQASAFCGLGFLIVLALFQAG	IWELLQASAFCGRGFLIVLALFQAG	9.0	6.0	-	-	4259_7:117175402-117175402 T>G_IWELLQASAFCGRGFLIVLALFQAG	0.0
3:113376897-113376897 T>C	1.0	4345	COLORECTAL	-	-	-	-	KIAA2018	ENST00000316407,p.E1211G|uc003eam.3,p.E1211G|uc003eal.3,p.E1155G|ENST00000478658,p.E1211G|NM_001009899,p.E1211G	retained_intron, protein_coding	uc003eam.3	nonsynonymous SNV	exon7	c.A3632G	p.E1211G	QGSIEATMERPLEKPSCSLGIKTSN	QGSIEATMERPLGKPSCSLGIKTSN	6.0	3.0	-	-	4345_3:113376897-113376897 T>C_QGSIEATMERPLGKPSCSLGIKTSN	0.0
19:41055311-41055311 G>C	0.0	4160	COLORECTAL	-	-	-	-	SPTBN4	ENST00000392023,p.D202H|ENST00000352632,p.D1526H|ENST00000598249,p.D1526H|NM_020971,p.D1526H|uc002onx.3,p.D1526H|ENST00000595535,p.D1526H|ENST00000338932,p.D1526H|uc002ooa.3,p.D202H|uc002ony.3,p.D1526H|ENST00000392025,p.D269H|uc010egy.1,p.D202H|uc010egx.3,p.D269H|NM_025213,p.D202H|uc002onz.3,p.D1526H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010egy.1	nonsynonymous SNV	exon4	c.G604C	p.D202H	SKELHQVAHDLDDELAWVQERLPLA	SKELHQVAHDLDHELAWVQERLPLA	3.0	9.0	-	-	4160_19:41055311-41055311 G>C_SKELHQVAHDLDHELAWVQERLPLA	0.0
19:23836934-23836934 ->TT	1.0	4213	COLORECTAL	-	-	-	-	ZNF675	ENST00000359788,p.Q267fs|uc002nri.3,p.Q267fs|NM_138330,p.Q267fs	retained_intron, protein_coding, nonsense_mediated_decay	uc002nri.3	frameshift insertion	exon4	c.800_801insAA	p.Q267fs	PYKCEECGKAFNQSSHLTTHKIIHT	PYKCEECGKAFNQSPHTLLHIR	8.0	7.0	-	-	4213_19:23836934-23836934 ->TT_PYKCEECGKAFNQSPHTLLHIR	0.0
8:110447572-110447572 G>A	0.0	4281	COLORECTAL	-	-	-	-	PKHD1L1	uc003yne.3,p.G1165E|NM_177531,p.G1165E|ENST00000378402,p.G1165E	retained_intron, protein_coding	uc003yne.3	nonsynonymous SNV	exon29	c.G3494A	p.G1165E	YQSQISHIWPDSGSIAGGTLLTLSG	YQSQISHIWPDSESIAGGTLLTLSG	2.0	5.0	-	-	4281_8:110447572-110447572 G>A_YQSQISHIWPDSESIAGGTLLTLSG	0.0
6:66115188-66115188 C>A	0.0	4252	COLORECTAL	-	-	-	-	EYS	uc003per.1,p.S312I|NM_001142801,p.S312I|ENST00000370618,p.S312I|ENST00000393380,p.S312I|NM_198283,p.S312I|NM_001142800,p.S312I|ENST00000503581,p.S312I|ENST00000342421,p.S312I|uc003peq.3,p.S312I|uc021zbn.1,p.S312I|NM_001292009,p.S312I|ENST00000370616,p.S312I|uc011dxu.1,p.S312I|ENST00000370621,p.S312I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zbn.1	nonsynonymous SNV	exon6	c.G935T	p.S312I	SLLFWKRGICPNSSSAYTYECPKGS	SLLFWKRGICPNISSAYTYECPKGS	3.0	9.0	-	-	4252_6:66115188-66115188 C>A_SLLFWKRGICPNISSAYTYECPKGS	0.0
18:24035751-24035751 G>A	1.0	4037	NSCLC	-	-	-	-	KCTD1	uc031rht.1,p.R244C|uc010xbj.3,p.R852C|ENST00000408011,p.R244C|NM_001142730,p.R852C|uc002kvw.4,p.R244C|uc010xbk.3,p.R244C|NM_001258222,p.R252C|uc031rhu.1,p.R252C|ENST00000317932,p.R244C|NM_001258221,p.R244C|ENST00000579973,p.R244C|ENST00000417602,p.R852C|ENST00000580059,p.R244C|NM_198991,p.R244C|NM_001136205,p.R244C	retained_intron, protein_coding, processed_transcript	uc031rhu.1	nonsynonymous SNV	exon5	c.C754T	p.R252C	EYVLRRELRRTPRVPSVIRIKQEPL	EYVLRRELRRTPCVPSVIRIKQEPL	9.0	9.0	-	-	4037_18:24035751-24035751 G>A_EYVLRRELRRTPCVPSVIRIKQEPL	0.0
12:56092686-56092686 G>A	1.0	4155	MELANOMA	-	-	-	-	ITGA7	ENST00000556273,p.S27L	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000556273	nonsynonymous SNV	exon3	c.C80T	p.S27L	EGFQCWRGFSIDSGKGLVRAEELSF	EGFQCWRGFSIDLGKGLVRAEELSF	10.0	9.0	-	-	4155_12:56092686-56092686 G>A_EGFQCWRGFSIDLGKGLVRAEELSF	0.0
6:123687324-123687324 G>C	0.0	3903	MELANOMA	-	-	-	-	TRDN	uc003pzj.2,p.T426S|uc003pzk.2,p.T427S|NM_001251987,p.T427S|ENST00000398178,p.T426S|ENST00000334268,p.T426S|NM_006073,p.T426S	protein_coding	uc003pzk.2	nonsynonymous SNV	exon20	c.C1280G	p.T427S	HSVPSDKQVKAKTERAKEEIGAVSI	HSVPSDKQVKAKSERAKEEIGAVSI	1.0	7.0	-	-	3903_6:123687324-123687324 G>C_HSVPSDKQVKAKSERAKEEIGAVSI	0.0
14:93650085-93650085 A>C	1.0	3713	MELANOMA	-	-	-	-	MOAP1	uc021saw.1,p.F168C|NM_022151,p.F168C|uc001ybj.3,p.F168C|ENST00000298894,p.F168C|ENST00000556883,p.F168C	protein_coding	uc021saw.1	nonsynonymous SNV	exon1	c.T503G	p.F168C	ALQCLKYKKLRVFSGRESPEPGEEE	ALQCLKYKKLRVCSGRESPEPGEEE	8.0	2.0	-	-	3713_14:93650085-93650085 A>C_ALQCLKYKKLRVCSGRESPEPGEEE	0.0
19:30502122-30502122 G>A	1.0	3903	MELANOMA	-	-	-	-	URI1	ENST00000360605,p.R368K|uc002nss.3,p.R346K|NM_001252641,p.R368K|NM_003796,p.R386K|ENST00000392271,p.R310K|ENST00000312051,p.R346K|uc002nsq.3,p.R368K|uc002nsr.3,p.R386K|ENST00000542441,p.R386K|uc002nst.3,p.R310K	protein_coding, processed_transcript, nonsense_mediated_decay	uc002nst.3	nonsynonymous SNV	exon7	c.G929A	p.R310K	GSGHSAQELPTIRTPADIYRAFVDV	GSGHSAQELPTIKTPADIYRAFVDV	9.0	9.0	-	-	3903_19:30502122-30502122 G>A_GSGHSAQELPTIKTPADIYRAFVDV	0.0
14:24000804-24000804 C>T	0.0	4186	BREAST	-	-	-	-	ZFHX2	NM_033400,p.D896N|uc010tno.2,p.D896N|ENST00000419474,p.D896N|uc001wke.3,p.D39N	protein_coding	uc010tno.2	nonsynonymous SNV	exon4	c.G2686A	p.D896N	AVLQHLRTPAHRDAQAQRRLQLLQN	AVLQHLRTPAHRNAQAQRRLQLLQN	4.0	5.0	-	-	4186_14:24000804-24000804 C>T_AVLQHLRTPAHRNAQAQRRLQLLQN	0.0
17:11532759-11532759 T>C	0.0	4149	OVARIAN	-	-	-	-	DNAH9	NM_001372,p.F459S|ENST00000454412,p.F459S|ENST00000262442,p.F459S|uc002gne.3,p.F459S	retained_intron, protein_coding, processed_transcript	uc002gne.3	nonsynonymous SNV	exon7	c.T1376C	p.F459S	HVVEGLLKTALDFHKLGKVEFSGVR	HVVEGLLKTALDSHKLGKVEFSGVR	9.0	6.0	-	-	4149_17:11532759-11532759 T>C_HVVEGLLKTALDSHKLGKVEFSGVR	0.0
19:39914273-39914273 C>T	1.0	3678	MELANOMA	-	-	-	-	PLEKHG2	NM_022835,p.P860L|ENST00000458508,p.P801L|uc010xuy.2,p.P801L|uc010xva.2,p.P638L|ENST00000409794,p.P860L|ENST00000600210,p.P69L|uc010xuz.2,p.P860L|ENST00000425673,p.P831L	retained_intron, protein_coding	uc010xva.2	nonsynonymous SNV	exon14	c.C1913T	p.P638L	RVLAQPQPSPCLPQEQAEPGLLPAF	RVLAQPQPSPCLLQEQAEPGLLPAF	7.0	7.0	-	-	3678_19:39914273-39914273 C>T_RVLAQPQPSPCLLQEQAEPGLLPAF	0.0
10:55587279-55587279 C>T	0.0	2359	MELANOMA	-	-	ID=COSM465745,COSM465744,COSM1135025,COSM465743;OCCURENCE=1(kidney),1(haematopoietic_and_lymphoid_tissue)	-	PCDH15	uc010qhw.1,p.R1374Q|uc021pqz.1,p.R1389Q|NM_001142767,p.R1374Q|uc010qib.1,p.R1389Q|NM_001142766,p.R1411Q|ENST00000395430,p.R1411Q|NM_001142773,p.R1389Q|ENST00000395432,p.R1374Q|ENST00000414778,p.R1416Q|uc010qhv.1,p.R1411Q|ENST00000395433,p.R1389Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pqz.1	nonsynonymous SNV	exon29	c.G4166A	p.R1389Q	YRQRQAECTKTARIQAALPAAKPAV	YRQRQAECTKTAQIQAALPAAKPAV	1.0	9.0	-	-	2359_10:55587279-55587279 C>T_YRQRQAECTKTAQIQAALPAAKPAV	0.0
2:186660972-186660972 A>C	1.0	4287	COLORECTAL	-	-	-	-	FSIP2	uc002upl.3,p.K3126Q|ENST00000343098,p.K3126Q|NM_173651,p.K3126Q|ENST00000424728,p.K3037Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002upl.3	nonsynonymous SNV	exon16	c.A9376C	p.K3126Q	ENLSSIQQKLLNKKMLPKLQPLKMF	ENLSSIQQKLLNQKMLPKLQPLKMF	3.0	8.0	-	-	4287_2:186660972-186660972 A>C_ENLSSIQQKLLNQKMLPKLQPLKMF	0.0
12:81768472-81768472 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	PPFIA2	uc031qik.1,p.A329S|NM_001220478,p.A304S|uc031qir.1,p.A403S|uc031qim.1,p.A403S|uc031qiv.1,p.A304S|uc031qin.1,p.A385S|uc031qix.1,p.A403S|uc031qiy.1,p.A403S|NM_001282536,p.A250S|uc031qiq.1,p.A385S|ENST00000333447,p.A385S|NM_003625,p.A403S|NM_001220473,p.A403S|ENST00000549396,p.A403S|uc031qiw.1,p.A403S|NM_001220474,p.A385S|ENST00000548586,p.A403S|ENST00000443686,p.A304S|uc031qip.1,p.A403S|uc031qis.1,p.A403S|uc031qil.1,p.A304S|ENST00000549325,p.A385S|uc031qiu.1,p.A329S|ENST00000550584,p.A403S|NM_001220477,p.A329S|NM_001220475,p.A403S|uc031qio.1,p.A403S|ENST00000550359,p.A250S|ENST00000552948,p.A403S|NM_001220476,p.A403S|ENST00000407050,p.A329S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qiy.1	nonsynonymous SNV	exon9	c.G1207T	p.A403S	LAEQKLQQTMRKAETLPEVEAELAQ	LAEQKLQQTMRKSETLPEVEAELAQ	4.0	9.0	-	-	4258_12:81768472-81768472 C>A_LAEQKLQQTMRKSETLPEVEAELAQ	0.0
2:70910851-70910851 C>T	0.0	2591	MELANOMA	-	-	-	-	ADD2	uc021vjc.1,p.E333K|ENST00000355733,p.E333K|uc002sgz.3,p.E333K|NM_001185055,p.E349K|ENST00000407644,p.E333K|uc010fdu.2,p.E349K|NM_017488,p.E333K|NM_001185054,p.E333K|ENST00000430656,p.E349K|NM_001617,p.E333K|uc010fdt.2,p.E333K|ENST00000413157,p.E333K|ENST00000264436,p.E333K|ENST00000403045,p.E333K|uc002sgy.3,p.E333K|uc002shc.2,p.E333K|NM_017482,p.E333K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vjc.1	nonsynonymous SNV	exon10	c.G997A	p.E333K	SSAGGVENLILLEQEKHRPHEVGSV	SSAGGVENLILLKQEKHRPHEVGSV	2.0	5.0	-	-	2591_2:70910851-70910851 C>T_SSAGGVENLILLKQEKHRPHEVGSV	0.0
19:48254780-48254780 C>T	1.0	3713	MELANOMA	-	-	-	-	GLTSCR2	NM_015710,p.P201L|ENST00000597985,p.P82L|uc002phm.2,p.P201L|ENST00000246802,p.P201L	retained_intron, protein_coding, processed_transcript	uc002phm.2	nonsynonymous SNV	exon5	c.C602T	p.P201L	ERPFYDLWASDNPLDRPLVGQDEFF	ERPFYDLWASDNLLDRPLVGQDEFF	10.0	10.0	-	-	3713_19:48254780-48254780 C>T_ERPFYDLWASDNLLDRPLVGQDEFF	0.0
9:16435575-16435575 G>A	1.0	3716	MELANOMA	-	-	-	-	BNC2	uc003zmj.3,p.P638S|uc003zmi.3,p.P638S|uc003zmm.3,p.P831S|ENST00000418777,p.P830S|ENST00000411752,p.P266S|uc003zmn.1,p.P638S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003zmn.1	nonsynonymous SNV	exon1	c.C1912T	p.P638S	HVCTVAGCNAAFPSRRSRDRNRNLR	HVCTVAGCNAAFSSRRSRDRNRNLR	9.0	10.0	-	-	3716_9:16435575-16435575 G>A_HVCTVAGCNAAFSSRRSRDRNRNLR	0.0
16:31447896-31447896 G>A	0.0	4158	COLORECTAL	-	-	-	-	ZNF843	ENST00000564218,p.A92V|uc021tgw.1,p.A92V|NM_001136509,p.A92V|uc010vfm.1,p.A92V|ENST00000315678,p.A92V	protein_coding	uc021tgw.1	nonsynonymous SNV	exon1	c.C275T	p.A92V	APASPLGRSHSSAGVRQGFSGQLCC	APASPLGRSHSSVGVRQGFSGQLCC	3.0	9.0	-	-	4158_16:31447896-31447896 G>A_APASPLGRSHSSVGVRQGFSGQLCC	0.0
2:107459646-107459646 G>A	0.0	4266	COLORECTAL	-	-	ID=COSM3701911,COSM3701912;OCCURENCE=1(liver)	-	ST6GAL2	NM_001142351,p.T263M|ENST00000361686,p.T263M|NM_032528,p.T263M|uc002tdr.3,p.T263M|ENST00000409382,p.T263M|ENST00000409087,p.T263M|NM_001142352,p.T263M|uc002tds.3,p.T263M|uc002tdq.3,p.T263M	protein_coding	uc002tds.3	nonsynonymous SNV	exon2	c.C788T	p.T263M	LLCQLRSRARVRTLDGTEAPFSALG	LLCQLRSRARVRMLDGTEAPFSALG	2.0	5.0	-	-	4266_2:107459646-107459646 G>A_LLCQLRSRARVRMLDGTEAPFSALG	0.0
6:28964178-28964178 C>G	0.0	3775	CERVICAL	-	-	-	-	ZNF311	uc003nlu.2,p.E201Q|uc011dlk.1,p.E109Q|uc003nlv.2,p.E109Q|NM_001010877,p.E201Q|ENST00000377179,p.E201Q	protein_coding, processed_transcript	uc011dlk.1	nonsynonymous SNV	exon6	c.G325C	p.E109Q	VKLENQWETSIREKLREEKEGSEEV	VKLENQWETSIRQKLREEKEGSEEV	4.0	6.0	-	-	3775_6:28964178-28964178 C>G_VKLENQWETSIRQKLREEKEGSEEV	0.0
12:31944968-31944968 T>C	0.0	4238	COLORECTAL	-	-	-	-	H3F3C	NM_001013699,p.T45A|ENST00000340398,p.T45A|uc001rkr.3,p.T45A	protein_coding	uc001rkr.3	nonsynonymous SNV	exon1	c.A133G	p.T45A	TCGVKPHRYRPGTVALREIRRYQKS	TCGVKPHRYRPGAVALREIRRYQKS	4.0	5.0	-	-	4238_12:31944968-31944968 T>C_TCGVKPHRYRPGAVALREIRRYQKS	0.0
10:11527038-11527038 T>A	1.0	4110	BILE DUCT	-	-	-	-	USP6NL	uc001iks.1,p.D303V|uc001ikt.3,p.D286V|NM_001080491,p.D303V|ENST00000277575,p.D303V|ENST00000379237,p.D286V|NM_014688,p.D286V	protein_coding	uc001ikt.3	nonsynonymous SNV	exon13	c.A857T	p.D286V	DRTPFTLNLRIWDIYIFEGERVLTA	DRTPFTLNLRIWVIYIFEGERVLTA	6.0	10.0	-	-	4110_10:11527038-11527038 T>A_DRTPFTLNLRIWVIYIFEGERVLTA	0.0
1:1571704-1571704 A>C	1.0	4320	COLORECTAL	-	-	-	-	CDK11B	uc001agw.1,p.L634R|uc001agx.1,p.L668R|uc001agy.1,p.L677R	protein_coding	uc001agy.1	nonsynonymous SNV	exon18	c.T2030G	p.L677R	PYNNLRKRFGALLSDQGFDLMNKFL	PYNNLRKRFGALRSDQGFDLMNKFL	10.0	4.0	-	-	4320_1:1571704-1571704 A>C_PYNNLRKRFGALRSDQGFDLMNKFL	0.0
11:3733954-3733954 G>A	1.0	3713	MELANOMA	-	-	-	1	NUP98	ENST00000355260,p.S861F|NM_139132,p.S861F|ENST00000359171,p.S861F|uc001lyj.2,p.S861F|ENST00000397007,p.S878F|uc001lyk.2,p.S878F|uc001lyh.3,p.S861F|NM_016320,p.S861F|ENST00000397004,p.S861F|NM_005387,p.S878F|ENST00000324932,p.S861F|NM_139131,p.S861F|uc001lyi.3,p.S861F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001lyk.2	nonsynonymous SNV	exon20	c.C2633T	p.S878F	YRPETGSWVFKVSHFSKYGLQDSDE	YRPETGSWVFKVFHFSKYGLQDSDE	9.0	8.0	-	-	3713_11:3733954-3733954 G>A_YRPETGSWVFKVFHFSKYGLQDSDE	0.0
7:151704956-151704956 A>G	0.0	4301	MELANOMA	-	-	-	-	GALNTL5	NM_145292,p.Y318C|uc003wkq.3,p.Y69C|uc010lqf.3,p.Y207C|uc003wkp.3,p.Y318C|ENST00000431418,p.Y318C|ENST00000392800,p.Y318C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010lqf.3	nonsynonymous SNV	exon8	c.A620G	p.Y207C	AMSGGIFAIRRHYFNEIGQYDKDMD	AMSGGIFAIRRHCFNEIGQYDKDMD	1.0	10.0	-	-	4301_7:151704956-151704956 A>G_AMSGGIFAIRRHCFNEIGQYDKDMD	0.0
5:140186956-140186956 C>T	0.0	4278	COLORECTAL	-	-	-	-	PCDHA4	uc011daa.2,p.R62C|NM_018907,p.R62C|ENST00000356878,p.R62C|uc003lhi.2,p.R62C|ENST00000512229,p.R62C|uc003lhh.1,p.R62C|ENST00000530339,p.R62C|NM_031500,p.R62C	protein_coding	uc011daa.2	nonsynonymous SNV	exon1	c.C184T	p.R62C	QDLGLELAELVPRLFRVASKGRGGL	QDLGLELAELVPCLFRVASKGRGGL	6.0	8.0	-	-	4278_5:140186956-140186956 C>T_QDLGLELAELVPCLFRVASKGRGGL	0.0
20:54824201-54824201 T>C	0.0	4281	COLORECTAL	-	-	-	-	MC3R	NM_019888,p.V101A|ENST00000243911,p.V101A|uc002xxb.2,p.V101A	protein_coding	uc002xxb.2	nonsynonymous SNV	exon1	c.T302C	p.V101A	VSNALETIMIAIVHSDYLTFEDQFI	VSNALETIMIAIAHSDYLTFEDQFI	2.0	4.0	-	-	4281_20:54824201-54824201 T>C_VSNALETIMIAIAHSDYLTFEDQFI	0.0
4:107249399-107249399 A>T	1.0	4078	GASTRIC	-	-	-	-	AIMP1	NM_001142416,p.K154N|uc003hyg.3,p.K130N|NM_001142415,p.K130N|ENST00000358008,p.K130N|uc003hyh.3,p.K154N|uc011cfg.2,p.K130N|ENST00000394701,p.K154N|ENST00000442366,p.K130N|NM_004757,p.K130N|ENST00000510207,p.K130N	protein_coding	uc011cfg.2	nonsynonymous SNV	exon4	c.A390T	p.K130N	GDEKKAKEKIEKKGEKKEKKQQSIA	GDEKKAKEKIEKNGEKKEKKQQSIA	7.0	8.0	-	-	4078_4:107249399-107249399 A>T_GDEKKAKEKIEKNGEKKEKKQQSIA	0.0
7:5567970-5567996 GATGACCTGGCCGTCAGGCAGCTCGTA>-	0.0	4326	BREAST	-	-	-	-	ACTB	uc003sor.4,p.118_126del|uc003sot.4,p.240_248del|uc003soq.4,p.118_126del|ENST00000331789,p.240_248del|NM_001101,p.240_248del	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003sot.4	nonframeshift deletion	exon4	c.718_744del	p.240_248del	ATAASSSSLEKSYELPDGQVITIGNE	ATAASSSSLEKSTIGNERFRCPEAL	10.0	6.0	-	-	4326_7:5567970-5567996 GATGACCTGGCCGTCAGGCAGCTCGTA>-_ATAASSSSLEKSTIGNERFRCPEAL	0.0
19:10398698-10398698 C>T	0.0	2556	MELANOMA	-	-	-	-	ICAM4	uc002mns.2,p.S245F|ENST00000380770,p.S245F|NM_001544,p.S245F	protein_coding	uc002mns.2	nonsynonymous SNV	exon3	c.C734T	p.S245F	AWSPAPTALASGSIAALVGILLTVG	AWSPAPTALASGFIAALVGILLTVG	3.0	4.0	-	-	2556_19:10398698-10398698 C>T_AWSPAPTALASGFIAALVGILLTVG	0.0
4:151199078-151199078 C>T	1.0	3713	MELANOMA	-	-	-	-	LRBA	uc010ipj.3,p.D2810N|uc003ilt.4,p.D1458N|ENST00000535741,p.D2799N|NM_001199282,p.D2798N|uc003ils.4,p.D705N|ENST00000357115,p.D2810N|uc003ilu.4,p.D2798N|uc003ilr.4,p.D230N|ENST00000510413,p.D2798N|uc010ipi.3,p.D332N|NM_006726,p.D2810N	retained_intron, protein_coding, processed_transcript	uc010ipj.3	nonsynonymous SNV	exon57	c.G8428A	p.D2810N	GDRGVVVVRQVSDLKQLFAYPGCDA	GDRGVVVVRQVSNLKQLFAYPGCDA	6.0	5.0	-	-	3713_4:151199078-151199078 C>T_GDRGVVVVRQVSNLKQLFAYPGCDA	0.0
6:30675441-30675441 C>T	1.0	4155	MELANOMA	-	-	-	-	MDC1	ENST00000376406,p.G972E|uc003nrg.4,p.G972E|NM_014641,p.G972E	retained_intron, protein_coding, processed_transcript	uc003nrg.4	nonsynonymous SNV	exon8	c.G2915A	p.G972E	GQASSPTPEPGVGAGDLPGPTSAPV	GQASSPTPEPGVEAGDLPGPTSAPV	8.0	9.0	-	-	4155_6:30675441-30675441 C>T_GQASSPTPEPGVEAGDLPGPTSAPV	0.0
3:52584833-52584833 C>T	1.0	4000	MELANOMA	-	-	-	1	PBRM1	ENST00000356770,p.G1450D|ENST00000296302,p.G1537D|ENST00000394830,p.G1430D|uc003der.2,p.G1450D|NM_018313,p.G1430D|uc003dey.2,p.G1430D|ENST00000409057,p.G1482D|uc003dew.2,p.G1482D|uc003des.2,p.G1537D|ENST00000410007,p.G1457D|uc010hmk.1,p.G1457D	retained_intron, protein_coding, nonsense_mediated_decay	uc010hmk.1	nonsynonymous SNV	exon27	c.G4370A	p.G1457D	PGVPGLPGIPPPGVMNQGVAPMVGT	PGVPGLPGIPPPDVMNQGVAPMVGT	9.0	4.0	-	-	4000_3:52584833-52584833 C>T_PGVPGLPGIPPPDVMNQGVAPMVGT	0.0
17:20149384-20149384 G>T	0.0	4234	NSCLC	-	-	-	2	SPECC1	NM_001033553,p.G833C|NM_001033555,p.G752C|uc002gwq.3,p.G833C|ENST00000395530,p.G752C|uc002gwv.3,p.G752C|ENST00000395527,p.G833C|uc002gws.3,p.G833C|uc010vzf.2,p.G173C|ENST00000536879,p.G173C|NM_001243439,p.G833C|ENST00000261503,p.G833C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vzf.2	nonsynonymous SNV	exon5	c.G517T	p.G173C	KSLIKSFDLGRPGGAGQNISVHKTP	KSLIKSFDLGRPCGAGQNISVHKTP	8.0	10.0	-	-	4234_17:20149384-20149384 G>T_KSLIKSFDLGRPCGAGQNISVHKTP	0.0
11:100226851-100226851 G>A	0.0	3903	MELANOMA	-	-	-	-	CNTN5	ENST00000524871,p.G1068E|NM_175566,p.G994E|uc021qpc.1,p.G994E|ENST00000528682,p.G1068E|uc001pga.3,p.G1068E|ENST00000279463,p.G1068E|NM_001243270,p.G1068E|uc010ruk.2,p.G339E|NM_014361,p.G1068E|ENST00000418526,p.G994E|uc021qpb.1,p.G1068E	retained_intron, protein_coding, processed_transcript	uc021qpc.1	nonsynonymous SNV	exon22	c.G2981A	p.G994E	ASSQIRVPSYSGGKITSAQSTLHSL	ASSQIRVPSYSGEKITSAQSTLHSL	1.0	8.0	-	-	3903_11:100226851-100226851 G>A_ASSQIRVPSYSGEKITSAQSTLHSL	0.0
1:38185600-38185600 C>A	1.0	4213	COLORECTAL	-	-	-	-	EPHA10	uc009vvi.3,p.W848L|ENST00000427468,p.W848L|ENST00000534097,p.W348L|ENST00000330210,p.W343L|ENST00000373048,p.W848L|NM_001099439,p.W848L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009vvi.3	nonsynonymous SNV	exon14	c.G2543T	p.W848L	MWEVMAFGERPYWDMSGQDVIKAVE	MWEVMAFGERPYLDMSGQDVIKAVE	7.0	6.0	-	-	4213_1:38185600-38185600 C>A_MWEVMAFGERPYLDMSGQDVIKAVE	0.0
17:60039134-60039134 G>A	1.0	3998	MELANOMA	-	-	-	-	MED13	NM_005121,p.P1691S|uc002izo.3,p.P1691S|ENST00000397786,p.P1691S	retained_intron, protein_coding, processed_transcript	uc002izo.3	nonsynonymous SNV	exon22	c.C5071T	p.P1691S	PHIKSTVSVQIIPCQYLLQPVKHED	PHIKSTVSVQIISCQYLLQPVKHED	10.0	6.0	CD8	-	3998_17:60039134-60039134 G>A_PHIKSTVSVQIISCQYLLQPVKHED	1.0
17:7415140-7415140 T>C	1.0	4196	COLORECTAL	-	-	-	-	POLR2A	NM_000937,p.I1371T|uc002ghf.4,p.I1371T|ENST00000322644,p.I1371T	retained_intron, protein_coding	uc002ghf.4	nonsynonymous SNV	exon25	c.T4112C	p.I1371T	SNDIVEIFTVLGIEAVRKALERELY	SNDIVEIFTVLGTEAVRKALERELY	10.0	9.0	-	-	4196_17:7415140-7415140 T>C_SNDIVEIFTVLGTEAVRKALERELY	0.0
4:650058-650058 G>A	0.0	4266	COLORECTAL	-	-	-	-	PDE6B	NM_001145292,p.A83T|ENST00000255622,p.A362T|NM_001145291,p.A362T|uc003gao.4,p.A362T|ENST00000496514,p.A362T|NM_000283,p.A362T|uc003gap.3,p.A362T|uc011buy.2,p.A83T|ENST00000429163,p.A83T	retained_intron, protein_coding	uc011buy.2	nonsynonymous SNV	exon6	c.G247A	p.A83T	ESGFICNIMNASADEMFKFQEGALD	ESGFICNIMNASTDEMFKFQEGALD	5.0	6.0	-	-	4266_4:650058-650058 G>A_ESGFICNIMNASTDEMFKFQEGALD	0.0
19:56435974-56435974 C>T	0.0	3903	MELANOMA	0.0032	-	-	-	NLRP13	ENST00000588751,p.E147K|ENST00000342929,p.E147K|uc010ygg.2,p.E147K|NM_176810,p.E147K	protein_coding	uc010ygg.2	nonsynonymous SNV	exon3	c.G439A	p.E147K	QGCQDPNQEELDELEEETGNVQAQG	QGCQDPNQEELDKLEEETGNVQAQG	1.0	8.0	-	-	3903_19:56435974-56435974 C>T_QGCQDPNQEELDKLEEETGNVQAQG	0.0
22:32797815-32797815 A>T	1.0	2369	MELANOMA	-	-	-	-	RTCB	ENST00000216038,p.V139E|uc003amm.2,p.V139E|NM_014306,p.V139E|ENST00000451746,p.V139E	retained_intron, protein_coding, processed_transcript	uc003amm.2	nonsynonymous SNV	exon5	c.T416A	p.V139E	LRTNLDESDVQPVKEQLAQAMFDHI	LRTNLDESDVQPEKEQLAQAMFDHI	10.0	5.0	-	-	2369_22:32797815-32797815 A>T_LRTNLDESDVQPEKEQLAQAMFDHI	0.0
2:152470801-152470801 G>C	0.0	4245	COLORECTAL	-	-	-	-	NEB	uc021vrc.1,p.L3864V|uc002txu.3,p.L3864V|NM_001271208,p.L3864V|NM_001164507,p.L3864V|uc021vrb.1,p.L3621V|ENST00000604864,p.L3864V|uc031rpp.1,p.L3864V|uc021vrd.1,p.L3621V|ENST00000427231,p.L3864V|ENST00000397345,p.L3864V|ENST00000172853,p.L3621V|ENST00000603639,p.L3864V|ENST00000409198,p.L3621V|NM_001164508,p.L3864V	retained_intron, protein_coding, processed_transcript	uc031rpp.1	nonsynonymous SNV	exon77	c.C11590G	p.L3864V	QNDVIQARKAYDLQSDAIYKSDLEW	QNDVIQARKAYDVQSDAIYKSDLEW	5.0	8.0	-	-	4245_2:152470801-152470801 G>C_QNDVIQARKAYDVQSDAIYKSDLEW	0.0
3:151100471-151100471 T>C	0.0	4245	COLORECTAL	-	-	-	-	MED12L	NM_053002,p.Y1505H|uc011bnz.2,p.Y1365H|uc003eyy.1,p.Y668H|ENST00000474524,p.Y1505H|uc003eyp.3,p.Y1505H|ENST00000273432,p.Y1365H	protein_coding, processed_transcript	uc011bnz.2	nonsynonymous SNV	exon29	c.T4093C	p.Y1365H	VNQILSNWREERYQDDIKARQMMHE	VNQILSNWREERHQDDIKARQMMHE	2.0	7.0	-	-	4245_3:151100471-151100471 T>C_VNQILSNWREERHQDDIKARQMMHE	0.0
19:18391408-18391408 A>T	1.0	4245	COLORECTAL	-	-	-	-	JUND	ENST00000600972,p.L34Q|NM_005354,p.L296Q|NM_001286968,p.L253Q|uc002nip.2,p.L296Q|ENST00000252818,p.L296Q	protein_coding, processed_transcript	uc002nip.2	nonsynonymous SNV	exon1	c.T887A	p.L296Q	KCRKRKLERISRLEEKVKTLKSQNT	KCRKRKLERISRQEEKVKTLKSQNT	10.0	6.0	-	-	4245_19:18391408-18391408 A>T_KCRKRKLERISRQEEKVKTLKSQNT	0.0
6:163235236-163235236 T>G	0.0	4278	COLORECTAL	-	-	-	-	PACRG	NM_152410,p.F72V|uc003qub.3,p.F72V|uc003qua.3,p.F72V|ENST00000366889,p.F72V|ENST00000337019,p.F72V|uc003quc.3,p.F72V|ENST00000366888,p.F72V|NM_001080379,p.F72V|NM_001080378,p.F72V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003quc.3	nonsynonymous SNV	exon2	c.T214G	p.F72V	GAFKERPTKPTAFRKFYERGDFPIA	GAFKERPTKPTAVRKFYERGDFPIA	4.0	2.0	-	-	4278_6:163235236-163235236 T>G_GAFKERPTKPTAVRKFYERGDFPIA	0.0
16:2114286-2114286 A>G	1.0	4037	NSCLC	-	-	-	1	TSC2	ENST00000568454,p.N497S|NM_000548,p.N486S|ENST00000353929,p.N486S|ENST00000350773,p.N486S|uc010uvw.2,p.N437S|uc002coo.3,p.N486S|uc002con.3,p.N486S|NM_001077183,p.N486S|NM_001114382,p.N486S|uc002cop.3,p.N286S|ENST00000401874,p.N486S|ENST00000382538,p.N437S|ENST00000219476,p.N486S|uc010uvv.2,p.N449S|ENST00000439673,p.N449S|uc010bsd.3,p.N486S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uvw.2	nonsynonymous SNV	exon14	c.A1310G	p.N437S	LINRQFYEEELINSVVISQLSHIPE	LINRQFYEEELISSVVISQLSHIPE	8.0	10.0	-	-	4037_16:2114286-2114286 A>G_LINRQFYEEELISSVVISQLSHIPE	0.0
1:221875984-221875984 G>A	1.0	3466	MELANOMA	-	-	-	-	DUSP10	NM_007207,p.H407Y|ENST00000366899,p.H407Y|uc001hmy.2,p.H407Y|ENST00000323825,p.H65Y|uc001hmz.2,p.H65Y|ENST00000544095,p.H65Y|uc001hmx.2,p.H65Y	protein_coding, processed_transcript	uc001hmz.2	nonsynonymous SNV	exon3	c.C193T	p.H65Y	EEAHQCGKGLLIHCQAGVSRSATIV	EEAHQCGKGLLIYCQAGVSRSATIV	8.0	7.0	-	-	3466_1:221875984-221875984 G>A_EEAHQCGKGLLIYCQAGVSRSATIV	0.0
7:150725677-150725677 C>G	1.0	4134	NSCLC	-	-	-	-	ABCB8	ENST00000488551,p.F25L|ENST00000470645,p.F25L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000488551	nonsynonymous SNV	exon1	c.C75G	p.F25L	GPFPGRLLPPLRFQTFSAVSCGEGV	GPFPGRLLPPLRLQTFSAVSCGEGV	7.0	6.0	-	-	4134_7:150725677-150725677 C>G_GPFPGRLLPPLRLQTFSAVSCGEGV	0.0
2:100917203-100917203 T>A	1.0	3903	MELANOMA	-	-	-	-	LONRF2	uc002tal.4,p.N323I|ENST00000393437,p.N323I|ENST00000409647,p.N80I|NM_198461,p.N323I	protein_coding	uc002tal.4	nonsynonymous SNV	exon4	c.A968T	p.N323I	EVLFSATANVHENLTSSIQSRLKAQ	EVLFSATANVHEILTSSIQSRLKAQ	4.0	4.0	-	-	3903_2:100917203-100917203 T>A_EVLFSATANVHEILTSSIQSRLKAQ	0.0
16:57608879-57608879 A>G	0.0	4077	BILE DUCT	-	-	-	-	GPR114	uc002ely.3,p.H454R|ENST00000349457,p.H454R|NM_153837,p.H454R|uc002elx.4,p.H454R|ENST00000340339,p.H454R	retained_intron, protein_coding, processed_transcript	uc002ely.3	nonsynonymous SNV	exon11	c.A1361G	p.H454R	RERADAPSVRACHDTVTVLGLTVLL	RERADAPSVRACRDTVTVLGLTVLL	4.0	4.0	-	-	4077_16:57608879-57608879 A>G_RERADAPSVRACRDTVTVLGLTVLL	0.0
6:13597242-13597242 T>G	1.0	4320	COLORECTAL	-	-	-	-	SIRT5	NM_012241,p.L204R|NM_001242827,p.L96R|ENST00000397350,p.L96R|ENST00000606117,p.L204R|NM_031244,p.L204R|uc003nay.3,p.L204R|uc003nax.3,p.L96R|ENST00000379262,p.L204R|uc003naw.3,p.L204R	protein_coding	uc003nay.3	nonsynonymous SNV	exon7	c.T611G	p.L204R	PGTQDASIPVEKLPRCEEAGCGGLL	PGTQDASIPVEKRPRCEEAGCGGLL	7.0	7.0	-	-	4320_6:13597242-13597242 T>G_PGTQDASIPVEKRPRCEEAGCGGLL	0.0
20:48253920-48253920 G>A	1.0	3784	MELANOMA	-	-	-	-	B4GALT5	uc002xuu.4,p.S326F|NM_004776,p.S326F|ENST00000371711,p.S326F	protein_coding	uc002xuu.4	nonsynonymous SNV	exon8	c.C977T	p.S326F	VSRPEGDTGKYKSIPHHHRGEVQFL	VSRPEGDTGKYKFIPHHHRGEVQFL	9.0	4.0	-	-	3784_20:48253920-48253920 G>A_VSRPEGDTGKYKFIPHHHRGEVQFL	0.0
16:56839486-56839486 T>A	1.0	4180	BREAST	-	-	-	-	NUP93	ENST00000568656,p.I144N|ENST00000567641,p.I21N|ENST00000308159,p.I144N|ENST00000569863,p.I21N|ENST00000569842,p.I144N|uc010vhi.2,p.I21N|uc002eka.3,p.I144N|NM_014669,p.I144N|ENST00000564887,p.I21N|NM_001242796,p.I21N|ENST00000568283,p.I21N|NM_001242795,p.I21N|ENST00000542526,p.I21N|uc002ekb.3,p.I21N	retained_intron, protein_coding, processed_transcript, TEC	uc010vhi.2	nonsynonymous SNV	exon3	c.T62A	p.I21N	SMLVEWEQVKQRILHTLLASGEDAL	SMLVEWEQVKQRNLHTLLASGEDAL	10.0	6.0	-	-	4180_16:56839486-56839486 T>A_SMLVEWEQVKQRNLHTLLASGEDAL	0.0
22:42382100-42382100 C>G	1.0	3775	CERVICAL	-	-	-	-	SEPT3	ENST00000406029,p.I41M|ENST00000449288,p.I92M|NM_019106,p.I105M|uc003bbs.4,p.I105M|ENST00000396425,p.I105M|ENST00000396426,p.I105M|uc003bbr.4,p.I105M|NM_145733,p.I105M|ENST00000291236,p.I41M|uc011apj.2,p.I41M	retained_intron, protein_coding, nonsense_mediated_decay	uc011apj.2	nonsynonymous SNV	exon2	c.C123G	p.I41M	WNREEKIPKTVEIKAIGHVIEEGGV	WNREEKIPKTVEMKAIGHVIEEGGV	5.0	6.0	-	-	3775_22:42382100-42382100 C>G_WNREEKIPKTVEMKAIGHVIEEGGV	0.0
6:131904992-131904992 G>A	0.0	2359	MELANOMA	-	-	ID=COSM1073247;OCCURENCE=1(endometrium)	-	ARG1	uc010kfm.2,p.G313R|uc003qcp.2,p.G305R|NM_000045,p.G305R|ENST00000476845,p.G219R|NM_001244438,p.G313R|ENST00000356962,p.G313R|ENST00000368087,p.G305R	protein_coding, processed_transcript	uc010kfm.2	nonsynonymous SNV	exon8	c.G937A	p.G313R	VNTAVAITLACFGLAREGNHKPIDY	VNTAVAITLACFRLAREGNHKPIDY	1.0	7.0	-	-	2359_6:131904992-131904992 G>A_VNTAVAITLACFRLAREGNHKPIDY	0.0
2:21260121-21260121 C>T	0.0	4298	COLORECTAL	-	-	ID=COSM3380027;OCCURENCE=1(pancreas)	-	APOB	ENST00000399256,p.V182M|uc002red.3,p.V182M|NM_000384,p.V182M|ENST00000233242,p.V182M	protein_coding	uc002red.3	nonsynonymous SNV	exon6	c.G544A	p.V182M	TEEAKQVLFLDTVYGNCSTHFTVKT	TEEAKQVLFLDTMYGNCSTHFTVKT	1.0	10.0	-	-	4298_2:21260121-21260121 C>T_TEEAKQVLFLDTMYGNCSTHFTVKT	0.0
16:67270598-67270598 G>A	1.0	3919	MELANOMA	-	-	ID=COSM140766;OCCURENCE=1(skin)	-	FHOD1	NM_013241,p.S394F|uc010ced.3,p.S201F|uc002esl.3,p.S394F|ENST00000258201,p.S394F	retained_intron, protein_coding, nonsense_mediated_decay	uc010ced.3	nonsynonymous SNV	exon9	c.C602T	p.S201F	PTGPASPVGPTSSTGPALLTGPASS	PTGPASPVGPTSFTGPALLTGPASS	9.0	6.0	-	-	3919_16:67270598-67270598 G>A_PTGPASPVGPTSFTGPALLTGPASS	0.0
1:28793028-28793028 C>T	1.0	3466	MELANOMA	-	-	-	-	PHACTR4	uc001bpy.3,p.S201F|NM_001048183,p.S191F|ENST00000373839,p.S191F|uc001bpw.3,p.S191F|uc001bpu.3,p.S191F|ENST00000373836,p.S201F|NM_023923,p.S201F|uc001bpx.3,p.S175F	protein_coding, processed_transcript	uc001bpy.3	nonsynonymous SNV	exon5	c.C602T	p.S201F	HEASEGQAKDATSSGGTARFIISTS	HEASEGQAKDATFSGGTARFIISTS	8.0	8.0	-	-	3466_1:28793028-28793028 C>T_HEASEGQAKDATFSGGTARFIISTS	0.0
12:53345928-53345928 G>A	1.0	3903	MELANOMA	-	-	-	-	KRT18	uc001sbe.3,p.R325K|ENST00000550600,p.R325K|ENST00000388835,p.R325K|uc009zmn.2,p.R325K|ENST00000388837,p.R325K|NM_000224,p.R325K|NM_199187,p.R325K|uc001sbg.3,p.R325K	retained_intron, protein_coding	uc009zmn.2	nonsynonymous SNV	exon7	c.G974A	p.R325K	MRNLKASLENSLREVEARYALQMEQ	MRNLKASLENSLKEVEARYALQMEQ	9.0	7.0	-	-	3903_12:53345928-53345928 G>A_MRNLKASLENSLKEVEARYALQMEQ	0.0
9:33047314-33047314 G>C	1.0	4252	COLORECTAL	-	-	-	-	SMU1	NM_018225,p.L507V|uc003zsf.1,p.L507V|uc011lnu.1,p.L346V|ENST00000397149,p.L507V|ENST00000536631,p.L346V	protein_coding	uc011lnu.1	nonsynonymous SNV	exon10	c.C1036G	p.L346V	HQNLIATYSEDGLLKLWKP	HQNLIATYSEDGVLKLWKP	9.0	10.0	-	-	4252_9:33047314-33047314 G>C_HQNLIATYSEDGVLKLWKP	0.0
7:74564379-74564379 C>T	1.0	4320	COLORECTAL	-	-	-	-	GTF2IRD2,GTF2IRD2B	NM_173537,p.T709M|NM_001003795,p.T709M|ENST00000418185,p.T256M|uc003ubu.3,p.T539M|ENST00000312575,p.T709M|uc003ubt.3,p.T709M|uc010lcd.3,p.T462M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010lcd.3	nonsynonymous SNV	exon15	c.C1385T	p.T462M	ELDSQYGSLLYYTEIKWLSRGLVLK	ELDSQYGSLLYYMEIKWLSRGLVLK	10.0	9.0	-	-	4320_7:74564379-74564379 C>T_ELDSQYGSLLYYMEIKWLSRGLVLK	0.0
12:6646556-6646556 G>A	0.0	2098	MELANOMA	-	-	-	-	GAPDH	ENST00000396856,p.M100I|ENST00000396859,p.M175I|uc031qfw.1,p.M133I|ENST00000396861,p.M175I|NM_001289746,p.M175I|ENST00000396858,p.M133I|ENST00000229239,p.M175I|NM_001289745,p.M175I|uc001qop.2,p.M175I|NM_002046,p.M175I|NM_001256799,p.M133I	retained_intron, protein_coding, processed_transcript	uc031qfw.1	nonsynonymous SNV	exon6	c.G399A	p.M133I	VIHDNFGIVEGLMTTVHAITATQKT	VIHDNFGIVEGLITTVHAITATQKT	10.0	1.0	CD8	-	2098_12:6646556-6646556 G>A_VIHDNFGIVEGLITTVHAITATQKT	1.0
12:52284785-52284785 C>G	0.0	4326	BREAST	-	-	-	-	ANKRD33	ENST00000301190,p.P352R|uc001rze.3,p.P248R|NM_182608,p.P352R|uc001rzd.3,p.P352R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rze.3	nonsynonymous SNV	exon6	c.C743G	p.P248R	KSVPELLGTAPPPPLVPQSPPGSPQ	KSVPELLGTAPPRPLVPQSPPGSPQ	2.0	10.0	-	-	4326_12:52284785-52284785 C>G_KSVPELLGTAPPRPLVPQSPPGSPQ	0.0
12:247905-247905 C>T	0.0	4160	COLORECTAL	-	-	-	-	IQSEC3	NM_015232,p.A156V|ENST00000326261,p.A459V|ENST00000538872,p.A459V|uc001qhw.2,p.A459V|ENST00000382841,p.A156V|uc001qhu.1,p.A156V|NM_001170738,p.A459V	retained_intron, protein_coding, processed_transcript	uc001qhw.2	nonsynonymous SNV	exon4	c.C1376T	p.A459V	PGLEAEGRAPESAGPGPGDDAAETP	PGLEAEGRAPESVGPGPGDDAAETP	4.0	8.0	-	-	4160_12:247905-247905 C>T_PGLEAEGRAPESVGPGPGDDAAETP	0.0
5:135392422-135392422 ->C	1.0	4346	COLORECTAL	-	-	-	-	TGFBI	ENST00000305126,p.V539fs|NM_000358,p.V539fs|uc003lbh.4,p.V365fs|uc003lbg.4,p.V272fs|ENST00000442011,p.V539fs|uc011cyb.2,p.V365fs|uc003lbf.4,p.V539fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cyb.2	frameshift insertion	exon8	c.1095dupC	p.V365fs	LTETLNREGVYTVFAPTNEAFRALP	LTETLNREGVYTVLCSHK	10.0	7.0	-	-	4346_5:135392422-135392422 ->C_LTETLNREGVYTVLCSHK	0.0
9:125152621-125152621 G>A	0.0	4278	COLORECTAL	0.01	-	-	-	PTGS1	NM_001271165,p.V372I|uc004bmh.2,p.V372I|NM_001271368,p.V419I|NM_001271367,p.V335I|ENST00000373698,p.V372I|NM_001271166,p.V335I|NM_001271164,p.V433I|uc031tey.1,p.V433I|uc004bmg.2,p.V481I|ENST00000362012,p.V481I|uc011lys.2,p.V419I|uc010mwb.2,p.V335I|NM_080591,p.V444I|ENST00000540753,p.V419I|NM_000962,p.V481I|ENST00000223423,p.V444I|uc004bmf.2,p.V444I|uc031tez.1,p.V335I|uc011lyt.2,p.V372I	protein_coding	uc031tez.1	nonsynonymous SNV	exon10	c.G1003A	p.V335I	FGMKPYTSFQELVGEKEMAAELEEL	FGMKPYTSFQELIGEKEMAAELEEL	7.0	2.0	-	-	4278_9:125152621-125152621 G>A_FGMKPYTSFQELIGEKEMAAELEEL	0.0
4:138451538-138451538 C>T	1.0	2556	MELANOMA	-	-	-	-	PCDH18	NM_019035,p.E569K|ENST00000344876,p.E569K|uc003ihg.4,p.E349K|NM_001300828,p.E569K|ENST00000412923,p.E569K|uc003ihe.4,p.E569K|uc003ihf.4,p.E562K|ENST00000507846,p.E349K	protein_coding	uc003ihg.4	nonsynonymous SNV	exon2	c.G1045A	p.E349K	VSNTTVVLTIIDENDNVPVVIGPAL	VSNTTVVLTIIDKNDNVPVVIGPAL	5.0	3.0	-	-	2556_4:138451538-138451538 C>T_VSNTTVVLTIIDKNDNVPVVIGPAL	0.0
1:207737268-207737268 T>G	0.0	4335	COLORECTAL	-	-	-	-	CR1	ENST00000367051,p.F766V|ENST00000400960,p.F766V|ENST00000367053,p.F766V|ENST00000367049,p.F1216V|uc021pij.1,p.F766V|NM_000651,p.F1216V|uc001hfy.3,p.F766V|NM_000573,p.F766V|uc001hfx.3,p.F1216V	retained_intron, protein_coding, processed_transcript	uc021pij.1	nonsynonymous SNV	exon14	c.T2296G	p.F766V	LHAERTQRDKDNFSPGQEVFYSCEP	LHAERTQRDKDNVSPGQEVFYSCEP	10.0	2.0	-	-	4335_1:207737268-207737268 T>G_LHAERTQRDKDNVSPGQEVFYSCEP	0.0
21:30434492-30434492 C>A	1.0	4180	BREAST	-	-	-	-	CCT8	ENST00000286788,p.R390M|uc002ynb.3,p.R390M|uc011acp.2,p.R371M|NM_006585,p.R390M|NM_001282907,p.R371M|ENST00000542732,p.R371M|uc002yna.3,p.R339M|uc011acq.2,p.R317M|ENST00000540844,p.R317M|NM_001282908,p.R339M|NM_001282909,p.R317M	retained_intron, protein_coding, processed_transcript	uc011acq.2	nonsynonymous SNV	exon10	c.G950T	p.R317M	RGSTDNLMDDIERAVDDGVNTFKVL	RGSTDNLMDDIEMAVDDGVNTFKVL	10.0	8.0	CD8	-	4180_21:30434492-30434492 C>A_RGSTDNLMDDIEMAVDDGVNTFKVL	2.0
16:30536932-30536932 G>C	1.0	4110	BILE DUCT	-	-	-	-	ZNF768	ENST00000562803,p.L146V|uc010vex.2,p.L146V|NM_024671,p.L177V|uc002dyk.4,p.L177V|uc010vew.2,p.L146V|ENST00000380412,p.L177V	protein_coding	uc010vex.2	nonsynonymous SNV	exon4	c.C436G	p.L146V	AQSSKFQEGAEMLLNPEEKSPLNIS	AQSSKFQEGAEMVLNPEEKSPLNIS	7.0	9.0	-	-	4110_16:30536932-30536932 G>C_AQSSKFQEGAEMVLNPEEKSPLNIS	0.0
5:82406865-82406865 C>T	1.0	3879	MELANOMA	-	-	-	-	XRCC4	uc003kib.3,p.S53F|NM_022550,p.S53F|ENST00000282268,p.S53F|ENST00000511817,p.S53F|NM_003401,p.S53F|uc003kia.1,p.S53F|NM_022406,p.S53F|ENST00000396027,p.S53F|uc003kic.3,p.S53F|uc003kie.3,p.S53F|uc003kid.3,p.S53F|ENST00000338635,p.S53F	protein_coding, processed_transcript	uc003kie.3	nonsynonymous SNV	exon3	c.C158T	p.S53F	SAWTGTVSESEISQEADDMAMEKGK	SAWTGTVSESEIFQEADDMAMEKGK	6.0	6.0	-	-	3879_5:82406865-82406865 C>T_SAWTGTVSESEIFQEADDMAMEKGK	0.0
1:245850810-245850810 G>T	0.0	4252	COLORECTAL	-	-	-	-	KIF26B	ENST00000407071,p.V1509F|uc001ibg.1,p.V1127F|uc001ibf.1,p.V1509F|uc001ibh.1,p.V751F|NM_018012,p.V1509F|ENST00000366518,p.V1128F	retained_intron, protein_coding, processed_transcript	uc001ibh.1	nonsynonymous SNV	exon3	c.G2251T	p.V751F	VSASPVTDNFRRVVDGCEMALPGLA	VSASPVTDNFRRFVDGCEMALPGLA	4.0	9.0	-	-	4252_1:245850810-245850810 G>T_VSASPVTDNFRRFVDGCEMALPGLA	0.0
7:40535981-40535981 C>T	0.0	4281	COLORECTAL	-	-	-	-	SUGCT	NM_001193313,p.P369L|uc003tho.2,p.P321L|uc003thn.2,p.P369L|ENST00000335693,p.P369L|NM_001193312,p.P321L|ENST00000401647,p.P321L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003tho.2	nonsynonymous SNV	exon11	c.C962T	p.P321L	GPINNMKNVFAEPQVLHNGLVMEME	GPINNMKNVFAELQVLHNGLVMEME	5.0	7.0	-	-	4281_7:40535981-40535981 C>T_GPINNMKNVFAELQVLHNGLVMEME	0.0
12:54686255-54686255 C>G	1.0	4213	COLORECTAL	-	-	-	-	NFE2	NM_006163,p.G342A|uc001sfq.4,p.G342A|ENST00000435572,p.G342A|ENST00000540264,p.G342A|uc001sfr.5,p.G342A|NM_001261461,p.G342A|ENST00000553070,p.G342A|ENST00000312156,p.G342A|uc009znl.4,p.G342A|NM_001136023,p.G342A|uc009znk.4,p.G342A	protein_coding	uc009znl.4	nonsynonymous SNV	exon4	c.G1025C	p.G342A	YRDIFQHLRDESGNSYSPEEYALQQ	YRDIFQHLRDESANSYSPEEYALQQ	6.0	6.0	-	-	4213_12:54686255-54686255 C>G_YRDIFQHLRDESANSYSPEEYALQQ	0.0
16:69996951-69996951 C>A	0.0	4246	COLORECTAL	-	-	-	-	CLEC18A	ENST00000568461,p.N428K|uc002eya.4,p.N428K|ENST00000449317,p.N437K|uc010vlo.3,p.N428K|ENST00000393701,p.N428K|NM_001136214,p.N428K|ENST00000288040,p.N428K|NM_182619,p.N428K|uc031qwv.1,p.N428K|uc002exz.4,p.N428K|NM_001271197,p.N428K	retained_intron, protein_coding	uc031qwv.1	nonsynonymous SNV	exon12	c.C1284A	p.N428K	AFNWNDQRCKTRNRYICQFAQEHIS	AFNWNDQRCKTRKRYICQFAQEHIS	5.0	2.0	-	-	4246_16:69996951-69996951 C>A_AFNWNDQRCKTRKRYICQFAQEHIS	0.0
7:133160209-133160209 C>T	1.0	4301	MELANOMA	-	-	ID=COSM1548154;OCCURENCE=1(lung)	-	EXOC4	NM_021807,p.P437L|NM_001037126,p.P437L|uc003vrj.3,p.P437L|ENST00000253861,p.P437L|uc003vri.3,p.P437L|uc011kpo.2,p.P336L|ENST00000393161,p.P437L|uc003vrk.3,p.P437L|ENST00000539845,p.P336L	retained_intron, protein_coding, processed_transcript	uc011kpo.2	nonsynonymous SNV	exon8	c.C1007T	p.P336L	FAAFFAKKKPQRPKNSLFKFESSSH	FAAFFAKKKPQRLKNSLFKFESSSH	9.0	10.0	CD8	-	4301_7:133160209-133160209 C>T_FAAFFAKKKPQRLKNSLFKFESSSH	1.0
16:69177182-69177182 A>G	1.0	4329	COLORECTAL	-	-	-	-	CIRH1A	ENST00000352319,p.I210V|uc010cfi.3,p.I127V|NM_032830,p.I210V|ENST00000567460,p.I127V|uc010cfj.1,p.I29V|uc002ewr.2,p.I210V|uc002ewt.4,p.I127V|uc002ews.4,p.I210V|ENST00000566227,p.I162V|ENST00000314423,p.I210V|ENST00000563094,p.I210V|ENST00000562237,p.I224V	retained_intron, protein_coding, processed_transcript	uc010cfj.1	nonsynonymous SNV	exon1	c.A85G	p.I29V	VWGVAFLSDGTIISVDSAGKVQFWD	VWGVAFLSDGTIVSVDSAGKVQFWD	10.0	7.0	-	-	4329_16:69177182-69177182 A>G_VWGVAFLSDGTIVSVDSAGKVQFWD	0.0
9:114840971-114840971 C>T	1.0	3466	MELANOMA	-	-	-	-	SUSD1	uc010mui.3,p.E534K|NM_001282640,p.E534K|uc010muj.3,p.E534K|ENST00000374270,p.E534K|ENST00000374263,p.E534K|NM_001282643,p.E534K|uc004bfu.3,p.E534K|ENST00000374264,p.E534K|NM_022486,p.E534K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010muj.3	nonsynonymous SNV	exon12	c.G1600A	p.E534K	LFHIWGQRWYQKEFAQEMTFNISSS	LFHIWGQRWYQKKFAQEMTFNISSS	4.0	9.0	-	-	3466_9:114840971-114840971 C>T_LFHIWGQRWYQKKFAQEMTFNISSS	0.0
2:191844514-191844514 G>A	1.0	3466	MELANOMA	-	-	-	-	STAT1	uc010fse.2,p.P571S|NM_139266,p.P571S|uc002usk.2,p.P571S|uc021vue.1,p.P383S|ENST00000361099,p.P571S|NM_007315,p.P571S|uc002usl.2,p.P573S|ENST00000409465,p.P571S|ENST00000392322,p.P571S|uc002usj.2,p.P571S|ENST00000392323,p.P573S	retained_intron, protein_coding, nonsense_mediated_decay	uc021vue.1	nonsynonymous SNV	exon18	c.C1147T	p.P383S	ESILELIKKHLLPLWNDGCIMGFIS	ESILELIKKHLLSLWNDGCIMGFIS	10.0	7.0	-	-	3466_2:191844514-191844514 G>A_ESILELIKKHLLSLWNDGCIMGFIS	0.0
X:86868983-86868983 T>G	0.0	4160	COLORECTAL	-	-	-	-	KLHL4	uc004efb.2,p.L176V|ENST00000373114,p.L176V|NM_019117,p.L176V|ENST00000373119,p.L176V|NM_057162,p.L176V|uc004efa.2,p.L176V	protein_coding	uc004efb.2	nonsynonymous SNV	exon2	c.T526G	p.L176V	HAEQTLRKMENYLKEKQLCDVLLIA	HAEQTLRKMENYVKEKQLCDVLLIA	2.0	4.0	-	-	4160_X:86868983-86868983 T>G_HAEQTLRKMENYVKEKQLCDVLLIA	0.0
9:35806217-35806217 C>T	1.0	3713	MELANOMA	0.0032	-	-	-	NPR2	uc010mlb.3,p.R763W|ENST00000447210,p.R46W|ENST00000342694,p.R787W|uc003zyd.3,p.R787W|NM_003995,p.R787W	retained_intron, protein_coding, nonsense_mediated_decay	uc010mlb.3	nonsynonymous SNV	exon14	c.C2287T	p.R763W	ERPDFGQIKGFIRRFNKEGGTSILD	ERPDFGQIKGFIWRFNKEGGTSILD	4.0	7.0	-	-	3713_9:35806217-35806217 C>T_ERPDFGQIKGFIWRFNKEGGTSILD	0.0
19:38103365-38103365 G>A	1.0	4281	COLORECTAL	0.0005	-	ID=COSM172757;OCCURENCE=1(large_intestine)	-	ZNF540	ENST00000589117,p.R363H|NM_152606,p.R395H|uc002ogu.4,p.R395H|NM_001172226,p.R363H|ENST00000343599,p.R395H|ENST00000316433,p.R395H|uc010efq.4,p.R363H|ENST00000586134,p.R395H|uc002ogq.4,p.R395H|NM_001172225,p.R395H|ENST00000592533,p.R395H	retained_intron, protein_coding, processed_transcript	uc010efq.4	nonsynonymous SNV	exon4	c.G1088A	p.R363H	YECKECGKSFNVRGQLNRHKTIHTG	YECKECGKSFNVHGQLNRHKTIHTG	4.0	6.0	-	-	4281_19:38103365-38103365 G>A_YECKECGKSFNVHGQLNRHKTIHTG	0.0
X:27765352-27765352 G>A	0.0	3795	MELANOMA	-	-	-	-	DCAF8L2	ENST00000451261,p.E114K|uc011mjy.2,p.E114K|NM_001136533,p.E114K	protein_coding, processed_transcript	uc011mjy.2	nonsynonymous SNV	exon1	c.G340A	p.E114K	HYPLVGEEETEREEEDEEIQEEGGE	HYPLVGEEETERKEEDEEIQEEGGE	1.0	8.0	-	-	3795_X:27765352-27765352 G>A_HYPLVGEEETERKEEDEEIQEEGGE	0.0
5:23524619-23524619 A>G	1.0	4284	COLORECTAL	-	-	-	-	PRDM9	ENST00000296682,p.E376G|NM_020227,p.E376G|uc003jgo.3,p.E376G	protein_coding	uc003jgo.3	nonsynonymous SNV	exon10	c.A1127G	p.E376G	ELGIKWGSKWKKELMAGREPKPEIH	ELGIKWGSKWKKGLMAGREPKPEIH	3.0	3.0	-	-	4284_5:23524619-23524619 A>G_ELGIKWGSKWKKGLMAGREPKPEIH	0.0
5:1394869-1394869 C>T	0.0	4252	COLORECTAL	-	-	-	-	SLC6A3	ENST00000270349,p.R615H|NM_001044,p.R615H|ENST00000453492,p.R615H|uc003jck.3,p.R615H	retained_intron, protein_coding	uc003jck.3	nonsynonymous SNV	exon15	c.G1844A	p.R615H	LVDRGEVRQFTLRHWLKV	LVDRGEVRQFTLHHWLKV	4.0	9.0	-	-	4252_5:1394869-1394869 C>T_LVDRGEVRQFTLHHWLKV	0.0
1:25747154-25747154 T>G	0.0	4189	MELANOMA	-	-	-	-	RHCE	uc001bkg.3,p.K42Q|NM_138617,p.K42Q|ENST00000349438,p.K42Q|ENST00000340849,p.K42Q|uc001bkh.3,p.K42Q|NM_138618,p.K42Q|NM_020485,p.K42Q|ENST00000455194,p.K42Q|ENST00000294413,p.K42Q|NM_138616,p.K42Q|uc001bki.3,p.K42Q|uc001bkf.3,p.K42Q|ENST00000243186,p.K42Q|ENST00000413854,p.K42Q|ENST00000346452,p.K42Q|uc031pln.1,p.K42Q|uc031plo.1,p.K42Q|ENST00000425135,p.K42Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031plo.1	nonsynonymous SNV	exon1	c.A124C	p.K42Q	FFTHYDASLEDQKGLVASYQVGQDL	FFTHYDASLEDQQGLVASYQVGQDL	5.0	10.0	-	-	4189_1:25747154-25747154 T>G_FFTHYDASLEDQQGLVASYQVGQDL	0.0
14:21485858-21485858 G>A	1.0	3903	MELANOMA	-	-	-	-	NDRG2	uc001vyy.3,p.S338F|NM_201537,p.S338F|uc001vzd.3,p.S338F|ENST00000397853,p.S338F|uc001vyu.3,p.S295F|NM_016250,p.S324F|uc001vyw.3,p.S324F|ENST00000553503,p.S324F|ENST00000350792,p.S324F|uc001vza.3,p.S324F|uc001vyt.3,p.S251F|NM_001282213,p.S324F|ENST00000555158,p.S324F|ENST00000298684,p.S295F|NM_001282211,p.S334F|ENST00000397858,p.S338F|ENST00000397847,p.S327F|ENST00000397856,p.S308F|NM_201539,p.S338F|NM_001282215,p.S327F|ENST00000554104,p.S251F|ENST00000556147,p.S338F|ENST00000360463,p.S324F|NM_201536,p.S324F|NM_201541,p.S324F|ENST00000554143,p.S324F|NM_201540,p.S338F|uc010aig.3,p.S327F|ENST00000298687,p.S338F|ENST00000397855,p.S295F|uc001vzc.3,p.S308F|NM_001282214,p.S324F|uc001vzb.3,p.S278F|uc001vyv.3,p.S324F|NM_201535,p.S338F|ENST00000403829,p.S334F|uc001vzg.3,p.S324F|uc001vzf.3,p.S324F|uc001vyx.3,p.S338F|ENST00000397844,p.S308F|NM_001282212,p.S308F|NM_201538,p.S324F|ENST00000397851,p.S338F|uc001vyz.3,p.S324F|uc010tll.2,p.S334F|NM_001282216,p.S278F|uc001vze.3,p.S338F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tll.2	nonsynonymous SNV	exon15	c.C1001T	p.S334F	SRSRTASLTSAASVDGNRSRSRTLS	SRSRTASLTSAAFVDGNRSRSRTLS	7.0	9.0	-	-	3903_14:21485858-21485858 G>A_SRSRTASLTSAAFVDGNRSRSRTLS	0.0
14:86089229-86089229 G>T	0.0	4238	COLORECTAL	-	-	-	-	FLRT2	ENST00000554746,p.M457I|ENST00000330753,p.M457I|uc010atd.3,p.M457I|uc001xvr.3,p.M457I|NM_013231,p.M457I|uc021rxf.1,p.M457I	retained_intron, protein_coding, processed_transcript	uc021rxf.1	nonsynonymous SNV	exon1	c.G1371T	p.M457I	FTVMAYKLTWVKMGHSLVGGIVQER	FTVMAYKLTWVKIGHSLVGGIVQER	2.0	6.0	-	-	4238_14:86089229-86089229 G>T_FTVMAYKLTWVKIGHSLVGGIVQER	0.0
7:92129085-92129085 C>T	0.0	3775	CERVICAL	-	-	-	-	PEX1	uc003uly.3,p.G884E|uc010ley.3,p.G827E|ENST00000248633,p.G884E|uc011khr.2,p.G676E|NM_000466,p.G884E|ENST00000428214,p.G827E|ENST00000438045,p.G562E|uc011khs.2,p.G562E|NM_001282678,p.G676E|NM_001282677,p.G827E	retained_intron, protein_coding, nonsense_mediated_decay	uc011khs.2	nonsynonymous SNV	exon13	c.G1685A	p.G562E	RQRTGILLYGPPGTGKTLLAGVIAR	RQRTGILLYGPPETGKTLLAGVIAR	8.0	5.0	-	-	3775_7:92129085-92129085 C>T_RQRTGILLYGPPETGKTLLAGVIAR	0.0
11:6424891-6424891 G>C	0.0	3795	MELANOMA	-	-	-	-	APBB1	NM_001257320,p.Q36E|ENST00000389906,p.Q295E|NM_145689,p.Q295E|uc031pyv.1,p.Q75E|uc009yfb.3,p.Q36E|ENST00000299402,p.Q295E|NM_001257326,p.Q36E|NM_001257319,p.Q75E|ENST00000530885,p.Q75E|ENST00000311051,p.Q295E|uc009yfa.3,p.Q36E|uc001mdb.2,p.Q295E|uc010rag.2,p.Q36E|uc001mdd.4,p.Q75E|uc031pyu.1,p.Q295E|NM_001257323,p.Q75E|ENST00000533407,p.Q36E|NM_001257321,p.Q36E|NM_001257325,p.Q60E|uc001mdc.1,p.Q295E|uc009yey.3,p.Q36E|uc031pyt.1,p.Q60E|NM_001164,p.Q295E|uc001mde.3,p.Q36E|uc010rah.2,p.Q36E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pyv.1	nonsynonymous SNV	exon2	c.C223G	p.Q75E	PGRASPSQGSSPQEESQLTWTGFAH	PGRASPSQGSSPEEESQLTWTGFAH	7.0	1.0	-	-	3795_11:6424891-6424891 G>C_PGRASPSQGSSPEEESQLTWTGFAH	0.0
20:52601929-52601929 G>A	0.0	4345	COLORECTAL	-	-	-	-	BCAS1	uc010zzb.1,p.S294L|ENST00000371440,p.S391L|uc010gil.1,p.S346L|uc002xws.2,p.S346L|uc010gim.2,p.S294L|NM_003657,p.S346L|ENST00000371435,p.S346L|ENST00000434986,p.S104L|uc010zza.1,p.S104L|ENST00000395961,p.S346L|uc002xwt.2,p.S346L|ENST00000448484,p.S253L	protein_coding	uc010zzb.1	nonsynonymous SNV	exon5	c.C881T	p.S294L	QGAGKNSKGCNPSGHTQSVTTPEPA	QGAGKNSKGCNPLGHTQSVTTPEPA	6.0	2.0	-	-	4345_20:52601929-52601929 G>A_QGAGKNSKGCNPLGHTQSVTTPEPA	0.0
20:33080354-33080354 G>A	1.0	3784	MELANOMA	-	-	-	-	ITCH	uc010geu.2,p.V831I|ENST00000262650,p.V831I|NM_001257137,p.V831I|ENST00000374864,p.V790I|ENST00000535650,p.V680I|NM_001257138,p.V680I|NM_031483,p.V790I|uc002xak.3,p.V790I|uc010zuj.2,p.V680I	protein_coding, processed_transcript	uc010zuj.2	nonsynonymous SNV	exon22	c.G2038A	p.V680I	IDNEKRMRLLQFVTGTCRLPVGGFA	IDNEKRMRLLQFITGTCRLPVGGFA	10.0	6.0	-	-	3784_20:33080354-33080354 G>A_IDNEKRMRLLQFITGTCRLPVGGFA	0.0
11:6644247-6644247 C>T	0.0	4177	PANCREATIC	-	-	-	-	DCHS1	uc001mem.1,p.G2887E|ENST00000299441,p.G2887E|NM_003737,p.G2887E	protein_coding	uc001mem.1	nonsynonymous SNV	exon21	c.G8660A	p.G2887E	RAPGSGTATSGGGGRTRREAPRELR	RAPGSGTATSGGEGRTRREAPRELR	3.0	9.0	-	-	4177_11:6644247-6644247 C>T_RAPGSGTATSGGEGRTRREAPRELR	0.0
X:71877487-71877487 C>T	1.0	4259	COLORECTAL	-	-	-	-	PHKA1	NM_001172436,p.R290H|ENST00000541944,p.R290H|ENST00000373545,p.R290H|ENST00000373539,p.R290H|ENST00000373542,p.R290H|uc004eay.4,p.R290H|NM_002637,p.R290H|NM_001122670,p.R290H|uc004eax.4,p.R290H|ENST00000339490,p.R290H|uc011mqi.2,p.R290H	protein_coding	uc011mqi.2	nonsynonymous SNV	exon9	c.G869A	p.R290H	LTKQEIITKLQGRYGCCRFLRDGYK	LTKQEIITKLQGHYGCCRFLRDGYK	6.0	4.0	-	-	4259_X:71877487-71877487 C>T_LTKQEIITKLQGHYGCCRFLRDGYK	0.0
5:1406344-1406344 A>G	0.0	4258	ENDOMETRIAL	-	-	-	-	SLC6A3	ENST00000270349,p.W520R|NM_001044,p.W520R|uc003jck.3,p.W520R|ENST00000453492,p.W520R	retained_intron, protein_coding	uc003jck.3	nonsynonymous SNV	exon12	c.T1558C	p.W520R	IQQMTGQRPSLYWRLCWKLVSPCFL	IQQMTGQRPSLYRRLCWKLVSPCFL	2.0	9.0	-	-	4258_5:1406344-1406344 A>G_IQQMTGQRPSLYRRLCWKLVSPCFL	0.0
17:62856500-62856500 G>A	1.0	4284	COLORECTAL	-	-	-	-	LRRC37A3	uc031rdx.1,p.A1261V|uc010wqg.1,p.A373V|uc031rdo.1,p.A293V|uc002jex.1,p.A232V|ENST00000584306,p.A1255V|uc010wqf.1,p.A293V|ENST00000400877,p.A293V|uc002jey.2,p.A1255V|uc031reb.1,p.A1206V|ENST00000334962,p.A232V|uc031rdu.1,p.A1131V|uc031rdz.1,p.A1231V|ENST00000339474,p.A373V|uc031rdq.1,p.A1204V|NM_199340,p.A1255V|ENST00000319651,p.A1255V|uc031rea.1,p.A1231V|uc031rdn.1,p.A261V|uc010dek.2,p.A1180V	protein_coding, processed_transcript	uc031reb.1	nonsynonymous SNV	exon7	c.C3617T	p.A1206V	AAVSVLKPFSKGAPSTSSPAKALPQ	AAVSVLKPFSKGVPSTSSPAKALPQ	10.0	9.0	-	-	4284_17:62856500-62856500 G>A_AAVSVLKPFSKGVPSTSSPAKALPQ	0.0
15:40099220-40099220 T>A	1.0	3713	MELANOMA	-	-	-	-	GPR176	uc010uck.2,p.I93F|NM_001271854,p.I137F|uc001zkj.2,p.I138F|uc001zkk.2,p.I137F|NM_001271855,p.I93F|NM_007223,p.I138F|ENST00000561100,p.I138F|ENST00000543580,p.I93F|ENST00000299092,p.I137F	protein_coding, processed_transcript	uc010uck.2	nonsynonymous SNV	exon2	c.A277T	p.I93F	VFCSVTILSFPAIALDRYYSVLYPL	VFCSVTILSFPAFALDRYYSVLYPL	4.0	8.0	-	-	3713_15:40099220-40099220 T>A_VFCSVTILSFPAFALDRYYSVLYPL	0.0
1:158151415-158151415 G>A	0.0	4186	BREAST	-	-	-	-	CD1D	uc009wss.3,p.D78N|uc009wsr.1,p.D78N|uc001frr.3,p.D78N|ENST00000368171,p.D78N|NM_001766,p.D78N	protein_coding	uc009wss.3	nonsynonymous SNV	exon2	c.G232A	p.D78N	RSLKPWSQGTFSDQQWETLQHIFRV	RSLKPWSQGTFSNQQWETLQHIFRV	1.0	10.0	-	-	4186_1:158151415-158151415 G>A_RSLKPWSQGTFSNQQWETLQHIFRV	0.0
11:120348974-120348974 G>C	1.0	4134	NSCLC	-	-	-	1	ARHGEF12	NM_001301084,p.Q1111H|ENST00000397843,p.Q1214H|ENST00000532993,p.Q1111H|uc009zau.1,p.Q1111H|uc001pxl.2,p.Q1214H|NM_001198665,p.Q1195H|ENST00000356641,p.Q1195H|NM_015313,p.Q1214H|uc009zat.3,p.Q1195H	retained_intron, protein_coding	uc009zau.1	nonsynonymous SNV	exon37	c.G3333C	p.Q1111H	KSEVRDLFVAERQFAKEQHTDGTLK	KSEVRDLFVAERHFAKEQHTDGTLK	8.0	4.0	-	-	4134_11:120348974-120348974 G>C_KSEVRDLFVAERHFAKEQHTDGTLK	0.0
19:53911036-53911036 A>T	0.0	3775	CERVICAL	-	-	-	-	ZNF765	ENST00000505866,p.R23S|uc010ydx.2,p.R76S|uc002qbm.3,p.R76S|ENST00000396408,p.R76S|NM_001040185,p.R76S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ydx.2	nonsynonymous SNV	exon6	c.A228T	p.R76S	GNREVFHAGTSQRHESHHNGDFCFQ	GNREVFHAGTSQSHESHHNGDFCFQ	6.0	6.0	-	-	3775_19:53911036-53911036 A>T_GNREVFHAGTSQSHESHHNGDFCFQ	0.0
8:132002719-132002719 G>A	0.0	4275	COLORECTAL	-	-	ID=COSM120831;OCCURENCE=1(upper_aerodigestive_tract)	-	ADCY8	uc003ytd.4,p.R344W|NM_001115,p.R344W|ENST00000286355,p.R344W|ENST00000377928,p.R344W|uc010mds.3,p.R344W	protein_coding	uc010mds.3	nonsynonymous SNV	exon2	c.C1030T	p.R344W	NTAGIFISYLSDRAQRQAFLETRRC	NTAGIFISYLSDWAQRQAFLETRRC	1.0	5.0	-	-	4275_8:132002719-132002719 G>A_NTAGIFISYLSDWAQRQAFLETRRC	0.0
13:25016762-25016762 G>A	0.0	4317	COLORECTAL	-	rs113301501	-	-	PARP4	uc001upl.3,p.T1170I|NM_006437,p.T1170I|ENST00000381989,p.T1170I	retained_intron, protein_coding, processed_transcript	uc001upl.3	nonsynonymous SNV	exon29	c.C3509T	p.T1170I	LIIKLSKENSLITQFTSFVAVEKRD	LIIKLSKENSLIIQFTSFVAVEKRD	10.0	8.0	-	-	4317_13:25016762-25016762 G>A_LIIKLSKENSLIIQFTSFVAVEKRD	0.0
19:8575824-8575824 C>A	1.0	4234	NSCLC	-	-	-	-	ZNF414	NM_001146175,p.R337L|uc002mke.4,p.R337L|ENST00000393927,p.R337L	retained_intron, protein_coding, nonsense_mediated_decay	uc002mke.4	nonsynonymous SNV	exon7	c.G1010T	p.R337L	YSCMQCAFSTASRPAMTLHLEDHRP	YSCMQCAFSTASLPAMTLHLEDHRP	8.0	9.0	-	-	4234_19:8575824-8575824 C>A_YSCMQCAFSTASLPAMTLHLEDHRP	0.0
9:117819464-117819464 C>T	0.0	4320	COLORECTAL	-	-	-	2	TNC	ENST00000542877,p.R1152Q|uc022bmj.1,p.R1152Q	protein_coding, processed_transcript	uc022bmj.1	nonsynonymous SNV	exon10	c.G3455A	p.R1152Q	FIVYLSGLAPSIRTKTISATATTEP	FIVYLSGLAPSIQTKTISATATTEP	8.0	7.0	-	-	4320_9:117819464-117819464 C>T_FIVYLSGLAPSIQTKTISATATTEP	0.0
12:123805079-123805079 T>G	1.0	4237	NSCLC	-	-	-	-	SBNO1	uc010tap.2,p.K856T|uc010tao.2,p.K855T|NM_018183,p.K855T|ENST00000420886,p.K856T|ENST00000602750,p.K855T|ENST00000267176,p.K855T|NM_001167856,p.K856T|ENST00000602398,p.K856T	protein_coding	uc010tap.2	nonsynonymous SNV	exon18	c.A2567C	p.K856T	SQDAVERAQQMKKDLLDKLEKLAED	SQDAVERAQQMKTDLLDKLEKLAED	7.0	4.0	-	-	4237_12:123805079-123805079 T>G_SQDAVERAQQMKTDLLDKLEKLAED	0.0
5:140953316-140953316 G>A	1.0	3466	MELANOMA	-	-	-	-	DIAPH1	uc003llc.4,p.P692S|ENST00000520569,p.P647S|ENST00000389057,p.P692S|uc021yep.1,p.P701S|ENST00000518047,p.P692S|ENST00000253811,p.P701S|uc003llb.4,p.P701S|ENST00000398562,p.P680S|uc021yeq.1,p.P692S|uc010jgc.1,p.P140S|NM_005219,p.P701S|ENST00000389054,p.P701S|ENST00000521457,p.P692S|ENST00000398566,p.P692S|ENST00000398557,p.P701S|NM_001079812,p.P692S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021yeq.1	nonsynonymous SNV	exon15	c.C2074T	p.P692S	PPPPPLPGSAGIPPPPPPLPGEAGM	PPPPPLPGSAGISPPPPPLPGEAGM	9.0	9.0	-	-	3466_5:140953316-140953316 G>A_PPPPPLPGSAGISPPPPPLPGEAGM	0.0
6:147057727-147057727 G>T	0.0	4287	COLORECTAL	-	-	-	-	ADGB	uc010khx.3,p.R963I|uc003qlp.3,p.R215I|ENST00000397944,p.R963I|ENST00000367493,p.R382I|ENST00000367490,p.R25I|NM_024694,p.R963I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010khx.3	nonsynonymous SNV	exon23	c.G2888T	p.R963I	EMNLEQYAVSLLRLMFKSKCKSLES	EMNLEQYAVSLLILMFKSKCKSLES	4.0	8.0	-	-	4287_6:147057727-147057727 G>T_EMNLEQYAVSLLILMFKSKCKSLES	0.0
X:65819438-65819438 T>A	0.0	4245	COLORECTAL	-	-	-	-	EDA2R	ENST00000253392,p.K282M|NM_001199687,p.K261M|ENST00000450752,p.K282M|ENST00000374719,p.K261M|uc004dws.3,p.K261M|ENST00000451436,p.K137M|uc011mpc.2,p.K137M|ENST00000456230,p.K261M|uc004dwq.3,p.K261M|ENST00000396050,p.K261M|uc004dwt.2,p.K282M|NM_021783,p.K261M|uc022byh.1,p.K263M|NM_001242310,p.K282M	protein_coding	uc022byh.1	nonsynonymous SNV	exon5	c.A788T	p.K263M	HSPIECTELDLQKFSSSASYTGAET	HSPIECTELDLQMFSSSASYTGAET	4.0	5.0	-	-	4245_X:65819438-65819438 T>A_HSPIECTELDLQMFSSSASYTGAET	0.0
10:102748754-102748754 A>G	0.0	4110	BILE DUCT	-	-	-	-	C10orf2	ENST00000370228,p.T263A|ENST00000311916,p.T263A|uc001ksf.2,p.T263A|uc001ksg.2,p.T263A|NM_021830,p.T263A|NM_001163812,p.T263A	protein_coding, processed_transcript	uc001ksg.2	nonsynonymous SNV	exon1	c.A787G	p.T263A	PLISRRDAEVVLTSRELDSLALNQS	PLISRRDAEVVLASRELDSLALNQS	5.0	7.0	-	-	4110_10:102748754-102748754 A>G_PLISRRDAEVVLASRELDSLALNQS	0.0
10:101981889-101981889 A>C	0.0	4335	COLORECTAL	-	-	-	-	CHUK	uc001kqp.3,p.L122R|NM_001278,p.L122R|ENST00000370397,p.L122R	protein_coding, processed_transcript	uc001kqp.3	nonsynonymous SNV	exon4	c.T365G	p.L122R	PENCCGLKESQILSLLSDIGSGIRY	PENCCGLKESQIRSLLSDIGSGIRY	7.0	2.0	-	-	4335_10:101981889-101981889 A>C_PENCCGLKESQIRSLLSDIGSGIRY	0.0
6:44118360-44118360 G>T	0.0	4077	BILE DUCT	-	-	-	-	TMEM63B	ENST00000259746,p.R556L|NM_018426,p.R556L|ENST00000323267,p.R556L|uc003owr.3,p.R556L|uc003ows.3,p.R459L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ows.3	nonsynonymous SNV	exon15	c.G1376T	p.R459L	LFDKKFLAEAAIRFECVFLPDNGAF	LFDKKFLAEAAILFECVFLPDNGAF	6.0	9.0	-	-	4077_6:44118360-44118360 G>T_LFDKKFLAEAAILFECVFLPDNGAF	0.0
2:216981466-216981466 T>C	1.0	4180	BREAST	-	-	-	-	XRCC5	uc002vfy.3,p.Y74H|ENST00000392132,p.Y74H|ENST00000417391,p.Y61H|ENST00000392133,p.Y74H|NM_021141,p.Y74H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002vfy.3	nonsynonymous SNV	exon3	c.T220C	p.Y74H	DGTDNPLSGGDQYQNITVHRHLMLP	DGTDNPLSGGDQHQNITVHRHLMLP	10.0	8.0	-	-	4180_2:216981466-216981466 T>C_DGTDNPLSGGDQHQNITVHRHLMLP	0.0
9:126150054-126150054 C>A	0.0	4298	COLORECTAL	-	-	-	-	DENND1A	ENST00000394219,p.S522I|uc011lzl.1,p.S329I|uc004bny.1,p.S293I|ENST00000542603,p.S296I|uc011lzm.1,p.S522I	protein_coding, processed_transcript	uc011lzm.1	nonsynonymous SNV	exon19	c.G1565T	p.S522I	SSDDECQREEGPSSGFTESFFFSAP	SSDDECQREEGPISGFTESFFFSAP	8.0	4.0	-	-	4298_9:126150054-126150054 C>A_SSDDECQREEGPISGFTESFFFSAP	0.0
11:406961-406961 C>T	1.0	4345	COLORECTAL	-	-	-	-	SIGIRR	ENST00000397632,p.R254H|ENST00000382520,p.R254H|uc001lpd.2,p.R254H|ENST00000431843,p.R254H|NM_001135054,p.R254H|NM_001135053,p.R254H|ENST00000531205,p.R254H|ENST00000332725,p.R254H|uc001lpg.3,p.R254H|ENST00000528209,p.R150H|NM_021805,p.R254H|uc001lpe.1,p.R254H|uc001lpf.2,p.R254H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001lpg.3	nonsynonymous SNV	exon7	c.G761A	p.R254H	FREGLCRLLELTRRPIFITFEGQRR	FREGLCRLLELTHRPIFITFEGQRR	9.0	6.0	-	-	4345_11:406961-406961 C>T_FREGLCRLLELTHRPIFITFEGQRR	0.0
4:187539723-187539723 C>A	1.0	4129	NSCLC	-	-	-	1	FAT1	NM_005245,p.V2673F|uc003izf.3,p.V2673F|ENST00000441802,p.V2673F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003izf.3	nonsynonymous SNV	exon10	c.G8017T	p.V2673F	LIGLENEFFTFFVRAVDNGSPSKES	LIGLENEFFTFFFRAVDNGSPSKES	10.0	8.0	-	-	4129_4:187539723-187539723 C>A_LIGLENEFFTFFFRAVDNGSPSKES	0.0
11:32635921-32635921 C>T	0.0	4252	COLORECTAL	-	-	ID=COSM1638819;OCCURENCE=1(stomach)	-	CCDC73	uc001mtv.4,p.R648Q|NM_001008391,p.R648Q|ENST00000335185,p.R648Q	protein_coding, processed_transcript	uc001mtv.4	nonsynonymous SNV	exon16	c.G1943A	p.R648Q	KKNPVPCQKYSLRNSSNVMLDDKQC	KKNPVPCQKYSLQNSSNVMLDDKQC	4.0	8.0	-	-	4252_11:32635921-32635921 C>T_KKNPVPCQKYSLQNSSNVMLDDKQC	0.0
17:37901554-37901554 C>G	1.0	4134	NSCLC	-	-	ID=COSM417558;OCCURENCE=1(urinary_tract)	-	GRB7	uc010cwc.3,p.S357C|NM_005310,p.S357C|ENST00000309185,p.S357C|NM_001242443,p.S357C|uc021twu.1,p.S380C|uc002hss.3,p.S357C|ENST00000394204,p.S357C|ENST00000309156,p.S357C|uc002hsr.3,p.S357C|ENST00000394209,p.S357C|uc002hst.3,p.S357C|ENST00000394211,p.S357C|NM_001242442,p.S380C|ENST00000445327,p.S380C|NM_001030002,p.S357C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021twu.1	nonsynonymous SNV	exon10	c.C1139G	p.S380C	NYQQAQSRHLHPSCLGSPPLRSASD	NYQQAQSRHLHPCCLGSPPLRSASD	9.0	9.0	CD8	-	4134_17:37901554-37901554 C>G_NYQQAQSRHLHPCCLGSPPLRSASD	2.0
5:37293083-37293083 G>A	1.0	4000	MELANOMA	-	-	-	-	NUP155	ENST00000231498,p.P1312L|uc010iuz.1,p.P1248L|ENST00000513532,p.P1248L|uc003jku.1,p.P1312L|ENST00000381843,p.P1253L|NM_004298,p.P1253L|NM_001278312,p.P1248L|uc003jkt.1,p.P1253L|NM_153485,p.P1312L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010iuz.1	nonsynonymous SNV	exon33	c.C3743T	p.P1248L	LEVYDQLFKSRDPFWNRMKKPLHLL	LEVYDQLFKSRDLFWNRMKKPLHLL	8.0	6.0	-	-	4000_5:37293083-37293083 G>A_LEVYDQLFKSRDLFWNRMKKPLHLL	0.0
2:74642502-74642502 G>A	0.0	3466	MELANOMA	-	-	-	-	C2orf81	ENST00000290390,p.P241S|ENST00000517883,p.P173S|NM_001145054,p.P241S|uc010yrq.1,p.P241S	protein_coding	uc010yrq.1	nonsynonymous SNV	exon4	c.C721T	p.P241S	LSASFQLSVEEAPADDADPSLDPYL	LSASFQLSVEEASADDADPSLDPYL	3.0	6.0	-	-	3466_2:74642502-74642502 G>A_LSASFQLSVEEASADDADPSLDPYL	0.0
1:65332583-65332583 C>T	1.0	3919	MELANOMA	-	-	-	1	JAK1	NM_002227,p.G319E|uc001dbu.1,p.G319E|ENST00000342505,p.G319E|uc009wam.1,p.G319E	protein_coding, processed_transcript	uc009wam.1	nonsynonymous SNV	exon8	c.G956A	p.G319E	GGNVLYYEVMVTGNLGIQWRHKPNV	GGNVLYYEVMVTENLGIQWRHKPNV	9.0	5.0	-	-	3919_1:65332583-65332583 C>T_GGNVLYYEVMVTENLGIQWRHKPNV	0.0
X:90691124-90691124 C>T	1.0	3784	MELANOMA	-	-	-	-	PABPC5	uc022bzs.1,p.P183L|ENST00000312600,p.P183L|uc004efg.3,p.P183L|ENST00000373105,p.P19L|NM_080832,p.P183L	protein_coding	uc022bzs.1	nonsynonymous SNV	exon1	c.C548T	p.P183L	NNRQVYVGRFKFPEERAAEVRTRDR	NNRQVYVGRFKFLEERAAEVRTRDR	4.0	10.0	-	-	3784_X:90691124-90691124 C>T_NNRQVYVGRFKFLEERAAEVRTRDR	0.0
3:150840754-150840754 ->A	0.0	4298	COLORECTAL	-	-	-	-	MED12L	ENST00000474524,p.A130fs|uc003eyp.3,p.A130fs|ENST00000309237,p.A130fs|NM_053002,p.A130fs|uc003eym.1,p.A130fs|ENST00000422248,p.A130fs|ENST00000273432,p.A130fs|uc003eyo.3,p.A130fs|uc003eyn.3,p.A130fs|uc011bnz.2,p.A130fs	protein_coding, processed_transcript	uc011bnz.2	frameshift insertion	exon3	c.390dupA	p.A130fs	SDLAGNKPLSILAKKVPILSKKEDV	SDLAGNKPLSILAKKGSYP	3.0	9.0	-	-	4298_3:150840754-150840754 ->A_SDLAGNKPLSILAKKGSYP	0.0
12:60098668-60098668 C>T	0.0	3919	MELANOMA	-	-	-	-	SLC16A7	ENST00000548610,p.S29F|ENST00000546459,p.S29F|ENST00000549465,p.S29F|ENST00000261187,p.S29F|ENST00000549305,p.S29F|NM_001270623,p.S29F|NM_001270622,p.S29F|ENST00000547379,p.S29F|ENST00000549928,p.S29F|ENST00000551877,p.S29F|ENST00000552432,p.S29F|uc001sqt.4,p.S29F|ENST00000549033,p.S29F|ENST00000552024,p.S29F|uc001sqs.4,p.S29F|uc001squ.4,p.S29F|ENST00000550062,p.S29F|NM_004731,p.S29F	protein_coding, processed_transcript, nonsense_mediated_decay	uc001squ.4	nonsynonymous SNV	exon2	c.C86T	p.S29F	GWGWIVVGAAFISIGFSYAFPKAVT	GWGWIVVGAAFIFIGFSYAFPKAVT	1.0	10.0	-	-	3919_12:60098668-60098668 C>T_GWGWIVVGAAFIFIGFSYAFPKAVT	0.0
17:35297989-35297989 C>A	0.0	4160	COLORECTAL	-	-	-	-	LHX1	uc010cux.1,p.N68K|uc002hnh.2,p.N160K|ENST00000254457,p.N160K|NM_005568,p.N160K	retained_intron, protein_coding, processed_transcript	uc010cux.1	nonsynonymous SNV	exon3	c.C204A	p.N68K	PSQDDAKDSESANVSDKEAGSNEND	PSQDDAKDSESAKVSDKEAGSNEND	1.0	5.0	-	-	4160_17:35297989-35297989 C>A_PSQDDAKDSESAKVSDKEAGSNEND	0.0
3:194181508-194181508 C>G	1.0	4245	COLORECTAL	-	-	-	-	ATP13A3	ENST00000439040,p.G35A|ENST00000457986,p.G35A|NM_024524,p.G35A|uc003fty.4,p.G35A|ENST00000446356,p.G35A|ENST00000256031,p.G35A	retained_intron, protein_coding	uc003fty.4	nonsynonymous SNV	exon3	c.G104C	p.G35A	NLSRWKLAIVSLGVICSGGFLLLLL	NLSRWKLAIVSLAVICSGGFLLLLL	7.0	4.0	-	-	4245_3:194181508-194181508 C>G_NLSRWKLAIVSLAVICSGGFLLLLL	0.0
6:117686839-117686839 C>T	0.0	2591	MELANOMA	-	-	-	1	ROS1	ENST00000368508,p.G960R|NM_002944,p.G960R|ENST00000368507,p.G955R|uc003pxp.1,p.G960R	protein_coding	uc003pxp.1	nonsynonymous SNV	exon19	c.G2878A	p.G960R	PDSVQESSFRIEGNASSFQILWNGP	PDSVQESSFRIERNASSFQILWNGP	1.0	6.0	-	-	2591_6:117686839-117686839 C>T_PDSVQESSFRIERNASSFQILWNGP	0.0
X:153578408-153578408 C>T	0.0	4081	COLORECTAL	-	-	-	2	FLNA	uc011mzn.1,p.G575S|ENST00000369850,p.G2442S|ENST00000422373,p.G2434S|NM_001456,p.G2434S|NM_001110556,p.G2442S|ENST00000360319,p.G2434S|ENST00000369856,p.G575S|uc004fkk.2,p.G2442S|uc010nuu.1,p.G2434S|ENST00000344736,p.G2402S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mzn.1	nonsynonymous SNV	exon16	c.G1723A	p.G575S	GLVSAYGAGLEGGVTGNPAEFVVNT	GLVSAYGAGLEGSVTGNPAEFVVNT	10.0	6.0	-	-	4081_X:153578408-153578408 C>T_GLVSAYGAGLEGSVTGNPAEFVVNT	0.0
11:67925228-67925228 A>G	0.0	2359	MELANOMA	-	-	-	-	SUV420H1	uc001onn.1,p.V690A|NM_017635,p.V862A|uc009yse.1,p.V448A|uc009ysf.2,p.V622A|NM_001300908,p.V622A|uc001onm.1,p.V862A|ENST00000304363,p.V862A|NM_001300907,p.V690A	retained_intron, protein_coding, nonsense_mediated_decay	uc009ysf.2	nonsynonymous SNV	exon11	c.T1865C	p.V622A	IPLPPAKRLRLIVGKDSIDIDISSR	IPLPPAKRLRLIAGKDSIDIDISSR	8.0	9.0	-	-	2359_11:67925228-67925228 A>G_IPLPPAKRLRLIAGKDSIDIDISSR	0.0
3:58849286-58849286 C>T	1.0	3879	MELANOMA	-	-	-	-	C3orf67	uc003dks.1,p.E221K|uc003dkv.1,p.E221K|ENST00000482387,p.E406K	protein_coding, processed_transcript, nonsense_mediated_decay	uc003dkv.1	nonsynonymous SNV	exon12	c.G661A	p.E221K	SEDDFYGGDSSEEGNHSIQGSRGPT	SEDDFYGGDSSEKGNHSIQGSRGPT	7.0	10.0	-	-	3879_3:58849286-58849286 C>T_SEDDFYGGDSSEKGNHSIQGSRGPT	0.0
19:14046591-14046591 G>C	0.0	4316	COLORECTAL	-	-	-	-	PODNL1	ENST00000254320,p.A71G|uc010xnj.2,p.A151G|uc002mxr.3,p.A153G|NM_001146254,p.A151G|uc010xni.2,p.A71G|NM_024825,p.A153G|ENST00000339560,p.A153G|ENST00000538371,p.A151G	protein_coding, processed_transcript	uc010xnj.2	nonsynonymous SNV	exon5	c.C452G	p.A151G	QFLPRSLRVADLAANQVMEIFPLTF	QFLPRSLRVADLGANQVMEIFPLTF	4.0	5.0	-	-	4316_19:14046591-14046591 G>C_QFLPRSLRVADLGANQVMEIFPLTF	0.0
7:150932667-150932667 C>T	1.0	3775	CERVICAL	-	-	-	-	CHPF2	NM_019015,p.S266F|ENST00000465601,p.S44F|ENST00000035307,p.S266F|uc003wjr.1,p.S266F|uc003wjq.1,p.S258F|ENST00000495645,p.S258F|NM_001284295,p.S258F	protein_coding, nonsense_mediated_decay	uc003wjr.1	nonsynonymous SNV	exon2	c.C797T	p.S266F	RPDEWLGRCLIDSLGVGCVSQHQGQ	RPDEWLGRCLIDFLGVGCVSQHQGQ	8.0	8.0	-	-	3775_7:150932667-150932667 C>T_RPDEWLGRCLIDFLGVGCVSQHQGQ	0.0
8:10387179-10387179 C>T	0.0	4081	COLORECTAL	-	-	-	-	PRSS55	NM_001197020,p.A106V|NM_198464,p.A106V|uc003wta.3,p.A106V|ENST00000328655,p.A106V|uc022art.1,p.A106V|ENST00000522210,p.A106V	protein_coding, nonsense_mediated_decay	uc022art.1	nonsynonymous SNV	exon2	c.C317T	p.A106V	GGSILNKWWILTAAHCLYSEELFPE	GGSILNKWWILTVAHCLYSEELFPE	1.0	7.0	-	-	4081_8:10387179-10387179 C>T_GGSILNKWWILTVAHCLYSEELFPE	0.0
1:11217312-11217312 A>C	1.0	4081	COLORECTAL	-	-	-	1	MTOR	NM_004958,p.W1456G|uc001asd.3,p.W1456G|ENST00000361445,p.W1456G	protein_coding, processed_transcript	uc001asd.3	nonsynonymous SNV	exon30	c.T4366G	p.W1456G	EIQATWYEKLHEWEDALVAYDKKMD	EIQATWYEKLHEGEDALVAYDKKMD	6.0	7.0	-	-	4081_1:11217312-11217312 A>C_EIQATWYEKLHEGEDALVAYDKKMD	0.0
X:3239947-3239947 G>A	0.0	3903	MELANOMA	-	-	-	-	MXRA5	uc004crg.4,p.S1260F|ENST00000217939,p.S1260F|NM_015419,p.S1260F	protein_coding	uc004crg.4	nonsynonymous SNV	exon5	c.C3779T	p.S1260F	VSSRASGSKPSPSPENKHRNIVTPS	VSSRASGSKPSPFPENKHRNIVTPS	5.0	10.0	-	-	3903_X:3239947-3239947 G>A_VSSRASGSKPSPFPENKHRNIVTPS	0.0
17:7126027-7126027 C>G	1.0	2591	MELANOMA	-	-	-	-	ACADVL	NM_001270448,p.T231R|ENST00000350303,p.T285R|NM_001270447,p.T330R|ENST00000356839,p.T307R|uc002gex.4,p.T231R|uc010vtp.3,p.T330R|NM_001033859,p.T285R|uc002gev.4,p.T307R|ENST00000543245,p.T330R|NM_000018,p.T307R|uc002gew.4,p.T285R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vtp.3	nonsynonymous SNV	exon11	c.C989G	p.T330R	PPEKKMGIKASNTAEVFFDGVRVPS	PPEKKMGIKASNRAEVFFDGVRVPS	10.0	4.0	-	-	2591_17:7126027-7126027 C>G_PPEKKMGIKASNRAEVFFDGVRVPS	0.0
14:95670665-95670665 C>T	1.0	3713	MELANOMA	-	-	-	-	CLMN	uc001yef.2,p.E341K|ENST00000298912,p.E341K|NM_024734,p.E341K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001yef.2	nonsynonymous SNV	exon9	c.G1021A	p.E341K	TENGERTYTVNHETSHPPPSKVFVC	TENGERTYTVNHKTSHPPPSKVFVC	7.0	3.0	-	-	3713_14:95670665-95670665 C>T_TENGERTYTVNHKTSHPPPSKVFVC	0.0
19:55253513-55253513 T>G	0.0	4196	COLORECTAL	-	-	-	-	KIR2DL3	ENST00000342376,p.V53G|uc002qgx.3,p.V53G|NM_015868,p.V53G|uc010erw.1,p.V53G|ENST00000434419,p.V53G	protein_coding	uc010erw.1	nonsynonymous SNV	exon3	c.T158G	p.V53G	SEETVILQCWSDVRFQHFLLHREGK	SEETVILQCWSDGRFQHFLLHREGK	4.0	3.0	-	-	4196_19:55253513-55253513 T>G_SEETVILQCWSDGRFQHFLLHREGK	0.0
1:27876613-27876613 C>T	1.0	4287	COLORECTAL	-	-	-	-	AHDC1	uc021ojw.1,p.A672T|uc009vsy.3,p.A672T|ENST00000374011,p.A672T|uc009vsz.1,p.A672T|NM_001029882,p.A672T|ENST00000247087,p.A672T	protein_coding, processed_transcript	uc021ojw.1	nonsynonymous SNV	exon1	c.G2014A	p.A672T	HRVQGFRRRGGKAGGFGGRGGGHAA	HRVQGFRRRGGKTGGFGGRGGGHAA	4.0	9.0	-	-	4287_1:27876613-27876613 C>T_HRVQGFRRRGGKTGGFGGRGGGHAA	0.0
9:140400484-140400484 C>T	1.0	3716	MELANOMA	-	-	-	-	PNPLA7	NM_001098537,p.R426K|uc004cnf.2,p.R401K|uc010ncj.1,p.R426K|ENST00000434090,p.R392K|ENST00000406427,p.R426K|NM_152286,p.R401K|ENST00000277531,p.R401K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ncj.1	nonsynonymous SNV	exon13	c.G1277A	p.R426K	ATSDLGMACDRARVFLHSDEHPGSS	ATSDLGMACDRAKVFLHSDEHPGSS	3.0	8.0	-	-	3716_9:140400484-140400484 C>T_ATSDLGMACDRAKVFLHSDEHPGSS	0.0
2:88890104-88890104 G>T	1.0	4320	COLORECTAL	-	-	-	-	EIF2AK3	uc002stc.4,p.S341Y|ENST00000419748,p.S190Y|ENST00000415570,p.S220Y|ENST00000303236,p.S341Y|NM_004836,p.S341Y	retained_intron, protein_coding, processed_transcript	uc002stc.4	nonsynonymous SNV	exon6	c.C1022A	p.S341Y	LEWEYQFCTPIASAWLLKDGKVIPI	LEWEYQFCTPIAYAWLLKDGKVIPI	9.0	7.0	-	-	4320_2:88890104-88890104 G>T_LEWEYQFCTPIAYAWLLKDGKVIPI	0.0
1:152080712-152080712 G>C	0.0	4335	COLORECTAL	-	-	-	-	TCHH	uc009wne.1,p.L1661V|ENST00000368804,p.L1661V|NM_007113,p.L1661V|uc001ezp.3,p.L1661V	protein_coding	uc009wne.1	nonsynonymous SNV	exon3	c.C4981G	p.L1661V	EPQLRRQEREQQLRHDRDRKFREEE	EPQLRRQEREQQVRHDRDRKFREEE	5.0	3.0	-	-	4335_1:152080712-152080712 G>C_EPQLRRQEREQQVRHDRDRKFREEE	0.0
1:52859265-52859265 G>A	1.0	3919	MELANOMA	-	-	-	-	ORC1	uc001ctu.3,p.S311L|uc001ctt.3,p.S311L|NM_001190818,p.S311L|NM_001190819,p.S311L|ENST00000371568,p.S311L|ENST00000371566,p.S311L|uc010oni.2,p.S311L|NM_004153,p.S311L	protein_coding, processed_transcript	uc010oni.2	nonsynonymous SNV	exon6	c.C932T	p.S311L	TGLSYTEDDKKASPEHRIILRTRIA	TGLSYTEDDKKALPEHRIILRTRIA	3.0	10.0	-	-	3919_1:52859265-52859265 G>A_TGLSYTEDDKKALPEHRIILRTRIA	0.0
12:53606949-53606949 ->GG	1.0	4326	BREAST	-	-	-	-	RARG	ENST00000425354,p.R366fs|uc001scg.3,p.R294fs|uc001scd.3,p.R355fs|ENST00000327550,p.R294fs|NM_001243731,p.R245fs|uc001sce.3,p.R366fs|NM_000966,p.R366fs|uc001scf.3,p.R366fs|uc010soc.2,p.R245fs|ENST00000543726,p.R344fs|uc010sob.2,p.R344fs|ENST00000394426,p.R366fs|NM_001243732,p.R344fs|NM_001243730,p.R294fs|ENST00000338561,p.R355fs|NM_001042728,p.R355fs	retained_intron, protein_coding, processed_transcript	uc010soc.2	frameshift insertion	exon7	c.733_734insCC	p.R245fs	QEPLLEALRLYARRRRPSQPYMFPR	QEPLLEALRLYAPGAGGPASPTCSQGC	6.0	6.0	-	-	4326_12:53606949-53606949 ->GG_QEPLLEALRLYAPGAGGPASPTCSQGC	0.0
X:17065475-17065475 T>A	1.0	4245	COLORECTAL	-	-	-	-	REPS2	uc011miw.1,p.F118L|uc004cxw.1,p.F258L|ENST00000380064,p.F119L|NM_001080975,p.F258L|ENST00000303843,p.F258L|ENST00000357277,p.F259L|NM_004726,p.F259L|uc004cxv.1,p.F259L	retained_intron, protein_coding, processed_transcript	uc011miw.1	nonsynonymous SNV	exon6	c.T354A	p.F118L	KPLRHQASLIRSFSVERELQDNSSY	KPLRHQASLIRSLSVERELQDNSSY	8.0	3.0	-	-	4245_X:17065475-17065475 T>A_KPLRHQASLIRSLSVERELQDNSSY	0.0
20:34136585-34136585 C>T	1.0	3795	MELANOMA	-	-	-	-	ERGIC3	uc002xct.3,p.P218S|ENST00000348547,p.P218S|uc010zvg.2,p.P218S|NM_015966,p.P218S|uc002xcs.3,p.P218S|NM_198398,p.P218S|ENST00000357394,p.P218S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zvg.2	nonsynonymous SNV	exon7	c.C652T	p.P218S	EVNKVAGNFHFAPGKSFQQSHVHVH	EVNKVAGNFHFASGKSFQQSHVHVH	10.0	6.0	-	-	3795_20:34136585-34136585 C>T_EVNKVAGNFHFASGKSFQQSHVHVH	0.0
19:45853668-45853668 G>A	1.0	3713	MELANOMA	-	-	-	-	KLC3	uc002pbg.1,p.E419K|ENST00000470402,p.E419K|ENST00000391946,p.E405K|uc010ejy.1,p.E404K|NM_177417,p.E405K|ENST00000585434,p.E404K|uc002pbf.1,p.E405K	retained_intron, protein_coding	uc010ejy.1	nonsynonymous SNV	exon9	c.G1210A	p.E404K	QAEELYKEILHKEDLPAPLGAPNTG	QAEELYKEILHKKDLPAPLGAPNTG	1.0	10.0	-	-	3713_19:45853668-45853668 G>A_QAEELYKEILHKKDLPAPLGAPNTG	0.0
17:20483213-20483213 G>A	0.0	4158	COLORECTAL	-	-	-	-	CDRT15L2	uc021tsn.1,p.G53R|ENST00000399044,p.G53R|NM_001190790,p.G53R	protein_coding	uc021tsn.1	nonsynonymous SNV	exon1	c.G157A	p.G53R	VRRRTQVPQDSPGQALAGQATPEIP	VRRRTQVPQDSPRQALAGQATPEIP	1.0	10.0	-	-	4158_17:20483213-20483213 G>A_VRRRTQVPQDSPRQALAGQATPEIP	0.0
5:36985923-36985923 C>T	1.0	3466	MELANOMA	-	-	-	-	NIPBL	ENST00000282516,p.P881S|uc003jkm.1,p.P760S|NM_015384,p.P881S|ENST00000448238,p.P881S|uc003jkl.4,p.P881S|uc003jkk.4,p.P881S|NM_133433,p.P881S	retained_intron, protein_coding, processed_transcript	uc003jkm.1	nonsynonymous SNV	exon6	c.C2278T	p.P760S	KHRHESGDSRERPSSGEQKSRPDSP	KHRHESGDSRERSSSGEQKSRPDSP	10.0	6.0	-	-	3466_5:36985923-36985923 C>T_KHRHESGDSRERSSSGEQKSRPDSP	0.0
2:220353321-220353321 C>G	0.0	4186	BREAST	-	-	-	-	SPEG	uc010fwg.3,p.L2654V|NM_005876,p.L2654V|ENST00000312358,p.L2654V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010fwg.3	nonsynonymous SNV	exon33	c.C7960G	p.L2654V	LSIPRAGKRHAGLYECSATNVLGSI	LSIPRAGKRHAGVYECSATNVLGSI	7.0	7.0	-	-	4186_2:220353321-220353321 C>G_LSIPRAGKRHAGVYECSATNVLGSI	0.0
1:200956224-200956224 C>T	0.0	4078	GASTRIC	-	-	-	-	KIF21B	uc009wzl.2,p.V1172I|ENST00000360529,p.V1172I|uc001gvr.2,p.V1172I|NM_001252102,p.V1172I|ENST00000461742,p.V1172I|NM_017596,p.V1172I|uc001gvs.2,p.V1172I|NM_001252103,p.V1172I|ENST00000422435,p.V1172I|ENST00000332129,p.V1172I|NM_001252100,p.V1172I|uc010ppn.2,p.V1172I	retained_intron, protein_coding, nonsense_mediated_decay	uc010ppn.2	nonsynonymous SNV	exon25	c.G3514A	p.V1172I	STKNITKSLASLVEIKEDGVGFSVR	STKNITKSLASLIEIKEDGVGFSVR	4.0	7.0	-	-	4078_1:200956224-200956224 C>T_STKNITKSLASLIEIKEDGVGFSVR	0.0
2:196673509-196673509 G>A	0.0	3903	MELANOMA	-	-	-	-	DNAH7	uc002utj.4,p.S3327F|ENST00000312428,p.S3327F|NM_018897,p.S3327F	retained_intron, protein_coding, processed_transcript	uc002utj.4	nonsynonymous SNV	exon53	c.C9980T	p.S3327F	PYANLCTWLPQKSWDEICRLDDLPA	PYANLCTWLPQKFWDEICRLDDLPA	3.0	3.0	-	-	3903_2:196673509-196673509 G>A_PYANLCTWLPQKFWDEICRLDDLPA	0.0
2:100209920-100209920 C>T	0.0	4245	COLORECTAL	-	-	-	1	AFF3	uc010yvr.1,p.A888T|uc010fiq.1,p.A735T|NM_002285,p.A735T|NM_001025108,p.A760T|ENST00000356421,p.A760T|ENST00000409236,p.A735T|uc002taf.3,p.A760T|uc002tah.1,p.A760T|ENST00000409579,p.A760T|ENST00000317233,p.A735T|uc002tag.3,p.A735T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yvr.1	nonsynonymous SNV	exon15	c.G2662A	p.A888T	VGSINARTTSDIAKELEEQFYTLVP	VGSINARTTSDITKELEEQFYTLVP	4.0	9.0	-	-	4245_2:100209920-100209920 C>T_VGSINARTTSDITKELEEQFYTLVP	0.0
4:152570664-152570664 G>A	0.0	2556	MELANOMA	-	-	-	-	FAM160A1	uc003imj.2,p.E491K|ENST00000435205,p.E491K|NM_001109977,p.E491K|ENST00000505231,p.E491K	protein_coding, processed_transcript	uc003imj.2	nonsynonymous SNV	exon11	c.G1471A	p.E491K	FPEAFSESACIVEYGKALDISYLQY	FPEAFSESACIVKYGKALDISYLQY	4.0	9.0	-	-	2556_4:152570664-152570664 G>A_FPEAFSESACIVKYGKALDISYLQY	0.0
7:12728105-12728105 G>T	0.0	4235	COLORECTAL	-	-	-	-	ARL4A	ENST00000396663,p.V76L|uc003ssq.3,p.V76L|ENST00000396664,p.V76L|ENST00000396662,p.V76L|uc003ssp.3,p.V76L|NM_005738,p.V76L|uc021zzr.1,p.V76L|uc003sss.3,p.V76L|NM_001037164,p.V76L|uc021zzq.1,p.V76L|NM_212460,p.V76L|NM_001195396,p.V76L|ENST00000404894,p.V76L|ENST00000356797,p.V76L	protein_coding	uc021zzr.1	nonsynonymous SNV	exon1	c.G226T	p.V76L	GNSKTVTFHFWDVGGQEKLRPLWKS	GNSKTVTFHFWDLGGQEKLRPLWKS	8.0	7.0	-	-	4235_7:12728105-12728105 G>T_GNSKTVTFHFWDLGGQEKLRPLWKS	0.0
7:97867888-97867888 G>A	1.0	3713	MELANOMA	-	-	-	-	TECPR1	ENST00000542604,p.P253L|NM_015395,p.P323L|ENST00000447648,p.P323L|ENST00000379795,p.P323L|uc003upg.4,p.P323L|uc003uph.2,p.P253L	retained_intron, protein_coding, processed_transcript	uc003uph.2	nonsynonymous SNV	exon8	c.C758T	p.P253L	KVWFRRGVNSHNPCGTSWIEMVGEM	KVWFRRGVNSHNLCGTSWIEMVGEM	6.0	6.0	-	-	3713_7:97867888-97867888 G>A_KVWFRRGVNSHNLCGTSWIEMVGEM	0.0
22:37533772-37533772 C>T	0.0	3903	MELANOMA	-	-	ID=COSM240225;OCCURENCE=1(prostate)	-	IL2RB	NM_000878,p.R131H|ENST00000429622,p.R131H|uc003aqv.1,p.R131H|ENST00000453962,p.R131H|ENST00000216223,p.R131H	retained_intron, protein_coding, nonsense_mediated_decay	uc003aqv.1	nonsynonymous SNV	exon6	c.G392A	p.R131H	MAIQDFKPFENLRLMAPISLQVVHV	MAIQDFKPFENLHLMAPISLQVVHV	9.0	2.0	-	-	3903_22:37533772-37533772 C>T_MAIQDFKPFENLHLMAPISLQVVHV	0.0
11:1955817-1955819 GAA>-	0.0	4186	BREAST	-	-	-	-	TNNT3	ENST00000381561,p.177_178del|ENST00000381589,p.172_173del|ENST00000381548,p.176_177del|ENST00000381549,p.166_167del|uc001luo.4,p.166_167del|NM_001042781,p.172_173del|NM_001297646,p.166_167del|uc001luw.4,p.166_167del|ENST00000397301,p.185_186del|ENST00000446240,p.155_156del|uc010qxf.2,p.172_173del|ENST00000453458,p.155_156del|ENST00000344578,p.161_162del|NM_001042782,p.166_167del|ENST00000381579,p.166_167del|NM_001042780,p.166_167del|uc001luu.4,p.174_175del|NM_006757,p.174_175del|uc010qxg.2,p.106_107del|ENST00000397304,p.155_156del|uc001lur.3,p.166_167del|ENST00000381558,p.166_167del|ENST00000381563,p.177_178del|uc001lun.2,p.70_71del|uc001luq.4,p.166_167del|ENST00000278317,p.174_175del|ENST00000360603,p.168_169del|uc001lup.4,p.172_173del|ENST00000381557,p.160_161del	protein_coding, processed_transcript	uc010qxg.2	nonframeshift deletion	exon8	c.318_320del	p.106_107del	DQKRGKKQTAREMKKKILAERRKPL	DQKRGKKQTAREMKKILAERRKPLN	4.0	10.0	-	-	4186_11:1955817-1955819 GAA>-_DQKRGKKQTAREMKKILAERRKPLN	0.0
10:73767160-73767160 C>T	0.0	4213	COLORECTAL	-	-	-	-	CHST3	uc001jsn.3,p.P124L|NM_004273,p.P124L|ENST00000373115,p.P124L	protein_coding	uc001jsn.3	nonsynonymous SNV	exon3	c.C371T	p.P124L	EEEEEQRKEEEPPRPAVAGPRRHVL	EEEEEQRKEEEPLRPAVAGPRRHVL	6.0	6.0	-	-	4213_10:73767160-73767160 C>T_EEEEEQRKEEEPLRPAVAGPRRHVL	0.0
9:134350745-134350745 C>T	1.0	3879	MELANOMA	-	-	-	-	PRRC2B	NM_013318,p.R1077C|ENST00000357304,p.R1077C|uc004cao.4,p.R435C|uc004can.4,p.R1077C|uc010mzj.1,p.R660C	protein_coding, processed_transcript	uc010mzj.1	nonsynonymous SNV	exon8	c.C1978T	p.R660C	RGRGRGFREFTFRGRPAGGNGSGLC	RGRGRGFREFTFCGRPAGGNGSGLC	9.0	10.0	-	-	3879_9:134350745-134350745 C>T_RGRGRGFREFTFCGRPAGGNGSGLC	0.0
16:30536442-30536442 G>T	1.0	4078	GASTRIC	-	-	-	-	ZNF768	uc010vew.2,p.S309Y|ENST00000562803,p.S309Y|ENST00000380412,p.S340Y|NM_024671,p.S340Y|uc010vex.2,p.S309Y|uc002dyk.4,p.S340Y	protein_coding	uc010vex.2	nonsynonymous SNV	exon4	c.C926A	p.S309Y	DSSYLLRHQRTHSGQKPYKCPHCGK	DSSYLLRHQRTHYGQKPYKCPHCGK	9.0	1.0	-	-	4078_16:30536442-30536442 G>T_DSSYLLRHQRTHYGQKPYKCPHCGK	0.0
17:37342761-37342761 G>A	1.0	2556	MELANOMA	-	-	-	-	CACNB1	NM_000723,p.P206S|NM_199248,p.P206S|uc002hrn.3,p.P206S|ENST00000394303,p.P206S|uc002hrm.2,p.P206S|ENST00000394310,p.P206S	retained_intron, protein_coding, processed_transcript	uc002hrn.3	nonsynonymous SNV	exon6	c.C616T	p.P206S	LGDVVTGTRRPTPPASAKQKQKSTE	LGDVVTGTRRPTSPASAKQKQKSTE	5.0	5.0	-	-	2556_17:37342761-37342761 G>A_LGDVVTGTRRPTSPASAKQKQKSTE	0.0
2:15696907-15696907 C>A	0.0	4234	NSCLC	-	-	-	-	NBAS	uc002rcc.2,p.S70I|ENST00000441750,p.S70I|NM_015909,p.S70I|ENST00000281513,p.S70I	retained_intron, protein_coding, nonsense_mediated_decay	uc002rcc.2	nonsynonymous SNV	exon3	c.G209T	p.S70I	DRLLFLRQYIWYSPAPFLLPDGLVR	DRLLFLRQYIWYIPAPFLLPDGLVR	8.0	4.0	CD8	-	4234_2:15696907-15696907 C>A_DRLLFLRQYIWYIPAPFLLPDGLVR	2.0
8:27145570-27145570 G>A	1.0	3466	MELANOMA	-	-	-	-	TRIM35	uc003xfl.1,p.H327Y|ENST00000305364,p.H327Y|NM_171982,p.H327Y	retained_intron, protein_coding	uc003xfl.1	nonsynonymous SNV	exon6	c.C979T	p.H327Y	LSVSDDLTSVTNHGYRVQVENPERF	LSVSDDLTSVTNYGYRVQVENPERF	8.0	8.0	-	-	3466_8:27145570-27145570 G>A_LSVSDDLTSVTNYGYRVQVENPERF	0.0
10:101136922-101136922 C>T	1.0	3879	MELANOMA	-	-	-	-	CNNM1	uc001kpp.4,p.L763F|uc010qpi.2,p.L784F|ENST00000446890,p.L692F|ENST00000370534,p.L419F|uc009xwf.3,p.L763F|NM_020348,p.L763F|ENST00000356713,p.L763F|ENST00000370528,p.L692F|uc031pwy.1,p.L163F|uc009xwg.3,p.L163F	protein_coding, processed_transcript	uc031pwy.1	nonsynonymous SNV	exon6	c.C487T	p.L163F	GSNTQLYSSSNNLYMPDYSVHILSD	GSNTQLYSSSNNFYMPDYSVHILSD	6.0	3.0	-	-	3879_10:101136922-101136922 C>T_GSNTQLYSSSNNFYMPDYSVHILSD	0.0
15:89010494-89010494 A>G	1.0	4180	BREAST	-	-	-	-	MRPL46	ENST00000312475,p.S39P|NM_022163,p.S39P|uc002bmj.2,p.S39P|ENST00000560703,p.S39P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002bmj.2	nonsynonymous SNV	exon1	c.T115C	p.S39P	LSSRSLALAAAPSSNGSPWRLLGAL	LSSRSLALAAAPPSNGSPWRLLGAL	9.0	10.0	-	-	4180_15:89010494-89010494 A>G_LSSRSLALAAAPPSNGSPWRLLGAL	0.0
1:115168538-115168538 T>G	0.0	4284	COLORECTAL	-	-	-	-	DENND2C	uc001efc.1,p.Q23P|NM_198459,p.Q23P|ENST00000393274,p.Q23P|ENST00000393276,p.Q23P|ENST00000393277,p.Q23P|uc001efd.1,p.Q23P|NM_001256404,p.Q23P	protein_coding, processed_transcript	uc001efd.1	nonsynonymous SNV	exon4	c.A68C	p.Q23P	QTLSRSHCKNIKQKISQWEGRANGI	QTLSRSHCKNIKPKISQWEGRANGI	4.0	7.0	-	-	4284_1:115168538-115168538 T>G_QTLSRSHCKNIKPKISQWEGRANGI	0.0
7:92761672-92761672 G>A	0.0	2359	MELANOMA	-	-	-	-	SAMD9L	ENST00000437805,p.L1205F|ENST00000318238,p.L1205F|uc003umj.1,p.L1205F|uc003umk.1,p.L1205F|ENST00000411955,p.L1205F|uc022ahh.1,p.L1205F|NM_152703,p.L1205F|uc010lfb.1,p.L1205F|uc010lfc.1,p.L1205F|uc003umh.1,p.L1205F|uc010lfd.1,p.L1205F|uc003umi.1,p.L1205F	protein_coding, processed_transcript	uc022ahh.1	nonsynonymous SNV	exon1	c.C3613T	p.L1205F	NTACFLGEIEVGLYTIQILQLTPFF	NTACFLGEIEVGFYTIQILQLTPFF	5.0	7.0	-	-	2359_7:92761672-92761672 G>A_NTACFLGEIEVGFYTIQILQLTPFF	0.0
17:12860030-12860030 A>G	0.0	4234	NSCLC	-	-	ID=COSM704976;OCCURENCE=1(lung)	-	ARHGAP44	uc002gnt.1,p.I160V|uc010vvl.2,p.I437V|uc002gnr.4,p.I437V|uc010vvk.2,p.I437V|NM_014859,p.I437V|ENST00000379672,p.I437V|uc010vvm.2,p.I437V|ENST00000583608,p.I41V|ENST00000544416,p.I437V|ENST00000340825,p.I437V|ENST00000262444,p.I437V|uc002gns.4,p.I237V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, lincRNA	uc010vvm.2	nonsynonymous SNV	exon15	c.A1309G	p.I437V	TVSLQIVGIIEPIIQHADWFFPGEI	TVSLQIVGIIEPVIQHADWFFPGEI	4.0	9.0	-	-	4234_17:12860030-12860030 A>G_TVSLQIVGIIEPVIQHADWFFPGEI	0.0
1:46977907-46977907 C>T	0.0	4238	COLORECTAL	0.0027	-	-	-	DMBX1	uc001cpx.3,p.A297V|uc001cpw.3,p.A292V|NM_172225,p.A292V|ENST00000360032,p.A292V|ENST00000371956,p.A297V|NM_147192,p.A297V	protein_coding	uc001cpx.3	nonsynonymous SNV	exon4	c.C890T	p.A297V	SFEVGGPAPAAAAAAAAVPYLGVNM	SFEVGGPAPAAAVAAAAVPYLGVNM	1.0	10.0	-	-	4238_1:46977907-46977907 C>T_SFEVGGPAPAAAVAAAAVPYLGVNM	0.0
8:126443244-126443244 C>A	0.0	4235	COLORECTAL	-	-	-	-	TRIB1	ENST00000311922,p.L34M|NM_025195,p.L34M|uc003yrx.3,p.L34M	protein_coding, processed_transcript	uc003yrx.3	nonsynonymous SNV	exon1	c.C100A	p.L34M	LFPATRGVPAKRLLDADDAAAVAAK	LFPATRGVPAKRMLDADDAAAVAAK	9.0	2.0	-	-	4235_8:126443244-126443244 C>A_LFPATRGVPAKRMLDADDAAAVAAK	0.0
X:26157208-26157208 G>C	0.0	3775	CERVICAL	-	-	ID=COSM3965072;OCCURENCE=1(lung)	-	MAGEB18	uc004dbq.2,p.E36Q|NM_173699,p.E36Q	protein_coding	uc004dbq.2	nonsynonymous SNV	exon2	c.G106C	p.E36Q	DLGATQATVAEGESPSSAYLLFGDR	DLGATQATVAEGQSPSSAYLLFGDR	1.0	7.0	-	-	3775_X:26157208-26157208 G>C_DLGATQATVAEGQSPSSAYLLFGDR	0.0
1:47278173-47278173 G>A	0.0	4301	MELANOMA	-	-	-	-	CYP4B1	ENST00000371919,p.G110S|uc009vym.3,p.G110S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009vym.3	nonsynonymous SNV	exon3	c.G328A	p.G110S	DYAKAVYSRGGRGLLVLEGPKWLQH	DYAKAVYSRGGRSLLVLEGPKWLQH	5.0	3.0	-	-	4301_1:47278173-47278173 G>A_DYAKAVYSRGGRSLLVLEGPKWLQH	0.0
7:126173490-126173490 G>A	0.0	2591	MELANOMA	-	-	ID=COSM141888;OCCURENCE=1(skin)	-	GRM8	NM_000845,p.S649F|ENST00000444921,p.S649F|uc003vlt.2,p.S649F|ENST00000339582,p.S649F|ENST00000472701,p.S649F|ENST00000358373,p.S649F|NM_001127323,p.S649F|uc003vlr.2,p.S649F	protein_coding, processed_transcript, nonsense_mediated_decay	uc003vlt.2	nonsynonymous SNV	exon9	c.C1946T	p.S649F	FLMIAAPDTIICSFRRVFLGLGMCF	FLMIAAPDTIICFFRRVFLGLGMCF	1.0	10.0	-	-	2591_7:126173490-126173490 G>A_FLMIAAPDTIICFFRRVFLGLGMCF	0.0
6:17799576-17799576 G>A	1.0	3713	MELANOMA	-	-	-	-	KIF13A	ENST00000378843,p.A904V|ENST00000378826,p.A904V|NM_001105568,p.A904V|ENST00000378816,p.A904V|ENST00000378814,p.A904V|ENST00000259711,p.A904V|NM_001105566,p.A904V|NM_001105567,p.A904V|uc003nci.4,p.A904V|uc003nch.4,p.A904V|uc003ncg.4,p.A904V|uc003ncf.3,p.A904V|NM_022113,p.A904V	retained_intron, protein_coding, processed_transcript	uc003nci.4	nonsynonymous SNV	exon22	c.C2711T	p.A904V	QYTFWDQCESTVAAPVVDPEVPSPQ	QYTFWDQCESTVVAPVVDPEVPSPQ	8.0	2.0	-	-	3713_6:17799576-17799576 G>A_QYTFWDQCESTVVAPVVDPEVPSPQ	0.0
2:97373457-97373457 G>A	1.0	4189	MELANOMA	-	-	-	-	LMAN2L	ENST00000534882,p.P155S|ENST00000426463,p.P166S|uc010yuv.2,p.P153S|NM_001142292,p.P311S|uc010yut.2,p.P166S|uc010yux.2,p.P155S|uc002swv.3,p.P311S|ENST00000377079,p.P311S|uc002swu.3,p.P300S|uc010yuw.2,p.P155S|NM_030805,p.P300S|ENST00000264963,p.P300S|ENST00000537039,p.P162S|uc010yuu.2,p.P164S	retained_intron, protein_coding, nonsense_mediated_decay	uc010yux.2	nonsynonymous SNV	exon6	c.C463T	p.P155S	DVFLPSVDNMKLPEMTAPLPPLSGL	DVFLPSVDNMKLSEMTAPLPPLSGL	6.0	3.0	-	-	4189_2:97373457-97373457 G>A_DVFLPSVDNMKLSEMTAPLPPLSGL	0.0
22:36688247-36688247 C>T	1.0	4245	COLORECTAL	-	-	-	1	MYH9	ENST00000216181,p.V1377M|NM_002473,p.V1377M|uc003apg.3,p.V1377M	retained_intron, protein_coding, processed_transcript	uc003apg.3	nonsynonymous SNV	exon31	c.G4129A	p.V1377M	QVADMKKKMEDSVGCLETAEEVKRK	QVADMKKKMEDSMGCLETAEEVKRK	10.0	3.0	-	-	4245_22:36688247-36688247 C>T_QVADMKKKMEDSMGCLETAEEVKRK	0.0
2:189870947-189870947 G>T	0.0	4335	COLORECTAL	-	-	-	2	COL3A1	NM_000090,p.D1019Y|ENST00000304636,p.D1019Y|uc002uqj.1,p.D1019Y	retained_intron, protein_coding	uc002uqj.1	nonsynonymous SNV	exon42	c.G3055T	p.D1019Y	AGEPGRDGNPGSDGLPGRDGSPGGK	AGEPGRDGNPGSYGLPGRDGSPGGK	10.0	8.0	-	-	4335_2:189870947-189870947 G>T_AGEPGRDGNPGSYGLPGRDGSPGGK	0.0
1:9109243-9109243 G>A	0.0	3466	MELANOMA	-	-	-	-	SLC2A5	uc010nzy.2,p.S11F|ENST00000536305,p.S11F	retained_intron, protein_coding, processed_transcript	uc010nzy.2	nonsynonymous SNV	exon1	c.C32T	p.S11F	MLELHSLTASSIMRVLIMRAPLR	MLELHSLTASFIMRVLIMRAPLR	8.0	8.0	-	-	3466_1:9109243-9109243 G>A_MLELHSLTASFIMRVLIMRAPLR	0.0
4:177052719-177052719 C>T	1.0	4284	COLORECTAL	-	-	-	-	WDR17	NM_181265,p.P310S|uc003iuj.3,p.P334S|ENST00000508596,p.P310S|uc003ium.4,p.P310S|ENST00000280190,p.P334S|ENST00000507824,p.P317S|ENST00000393643,p.P310S|NM_170710,p.P334S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ium.4	nonsynonymous SNV	exon7	c.C928T	p.P310S	NSPPRKKFSVQSPTKNHYTSSTSEA	NSPPRKKFSVQSSTKNHYTSSTSEA	6.0	6.0	-	-	4284_4:177052719-177052719 C>T_NSPPRKKFSVQSSTKNHYTSSTSEA	0.0
10:98311035-98311035 A>G	1.0	4287	COLORECTAL	-	-	-	-	TM9SF3	uc001kmm.4,p.I309T|NM_020123,p.I309T|ENST00000371142,p.I309T	protein_coding, processed_transcript	uc001kmm.4	nonsynonymous SNV	exon7	c.T926C	p.I309T	SGCQIFAVSLIVIIVAMIEDLYTER	SGCQIFAVSLIVTIVAMIEDLYTER	10.0	3.0	-	-	4287_10:98311035-98311035 A>G_SGCQIFAVSLIVTIVAMIEDLYTER	0.0
1:84878212-84878212 C>T	0.0	4298	COLORECTAL	-	-	-	-	DNASE2B	NM_058248,p.S35L|ENST00000370662,p.S35L|uc001dju.1,p.S35L|uc009wch.1,p.S35L|ENST00000370665,p.S243L|uc001djt.1,p.S243L|NM_021233,p.S243L	protein_coding	uc009wch.1	nonsynonymous SNV	exon3	c.C104T	p.S35L	SAQGQKFLHFAKSDSFLDDIFAAWM	SAQGQKFLHFAKLDSFLDDIFAAWM	3.0	1.0	-	-	4298_1:84878212-84878212 C>T_SAQGQKFLHFAKLDSFLDDIFAAWM	0.0
5:23527239-23527239 C>G	0.0	4246	COLORECTAL	-	-	-	-	PRDM9	ENST00000296682,p.T681S|NM_020227,p.T681S|uc003jgo.3,p.T681S	protein_coding	uc003jgo.3	nonsynonymous SNV	exon11	c.C2042G	p.T681S	CGRGFSWQSVLLTHQRTHTGEKPYV	CGRGFSWQSVLLSHQRTHTGEKPYV	2.0	10.0	-	-	4246_5:23527239-23527239 C>G_CGRGFSWQSVLLSHQRTHTGEKPYV	0.0
11:4936551-4936551 G>A	0.0	3903	MELANOMA	-	-	-	-	OR51G2	NM_001005238,p.L115F|ENST00000322013,p.L115F|uc001lzr.1,p.L115F	protein_coding	uc001lzr.1	nonsynonymous SNV	exon1	c.C343T	p.L115F	FAQLFFIHCFSFLESSVLLSMAFDR	FAQLFFIHCFSFFESSVLLSMAFDR	1.0	4.0	-	-	3903_11:4936551-4936551 G>A_FAQLFFIHCFSFFESSVLLSMAFDR	0.0
2:210681738-210681738 G>C	1.0	4326	BREAST	-	-	-	-	UNC80	NM_182587,p.D481H|ENST00000272845,p.D481H|NM_032504,p.D481H|uc021vvx.1,p.D481H|ENST00000439458,p.D481H|uc010zjc.1,p.D481H	retained_intron, protein_coding, processed_transcript	uc021vvx.1	nonsynonymous SNV	exon10	c.G1441C	p.D481H	PRRMGVPFLLHEDHLDVSPTRSTFS	PRRMGVPFLLHEHHLDVSPTRSTFS	3.0	9.0	-	-	4326_2:210681738-210681738 G>C_PRRMGVPFLLHEHHLDVSPTRSTFS	0.0
11:17531037-17531037 C>T	0.0	4335	COLORECTAL	-	-	-	-	USH1C	ENST00000005226,p.E627K|NM_153676,p.E627K|uc001mne.3,p.E627K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, TEC	uc001mne.3	nonsynonymous SNV	exon18	c.G1879A	p.E627K	DLTPTRPLPSALEEALSNHPFRTGD	DLTPTRPLPSALKEALSNHPFRTGD	8.0	6.0	-	-	4335_11:17531037-17531037 C>T_DLTPTRPLPSALKEALSNHPFRTGD	0.0
5:41158793-41158793 C>T	0.0	3903	MELANOMA	-	-	-	-	C6	uc003jml.2,p.E651K|ENST00000263413,p.E651K|ENST00000337836,p.E651K|uc003jmk.3,p.E651K|NM_000065,p.E651K|NM_001115131,p.E651K	retained_intron, protein_coding, processed_transcript	uc003jml.2	nonsynonymous SNV	exon13	c.G1951A	p.E651K	EADSGCPQPVPPENGFIRNEKQLYL	EADSGCPQPVPPKNGFIRNEKQLYL	3.0	2.0	-	-	3903_5:41158793-41158793 C>T_EADSGCPQPVPPKNGFIRNEKQLYL	0.0
12:116443759-116443759 C>T	1.0	4196	COLORECTAL	-	-	-	-	MED13L	NM_015335,p.S795N|uc001tvw.3,p.S795N|ENST00000281928,p.S795N	retained_intron, protein_coding, processed_transcript	uc001tvw.3	nonsynonymous SNV	exon13	c.G2384A	p.S795N	VRQDNAAGRAGSSSLTQVTDLAPSL	VRQDNAAGRAGSNSLTQVTDLAPSL	10.0	6.0	-	-	4196_12:116443759-116443759 C>T_VRQDNAAGRAGSNSLTQVTDLAPSL	0.0
12:51449713-51449713 C>T	1.0	3713	MELANOMA	-	-	-	-	LETMD1	ENST00000262055,p.S190F|uc001rxm.3,p.S190F|NM_001243689,p.S203F|ENST00000418425,p.S203F|ENST00000551477,p.S157F|ENST00000550929,p.S134F|uc001rxl.3,p.S134F|NM_015416,p.S190F|uc009zlw.3,p.S203F|ENST00000552739,p.S73F|uc010smz.2,p.S140F|ENST00000549340,p.S140F|uc001rxn.3,p.S33F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, TEC	uc010smz.2	nonsynonymous SNV	exon4	c.C419T	p.S140F	DFLDIYHAFRKQSHPEIISYLEKVI	DFLDIYHAFRKQFHPEIISYLEKVI	10.0	5.0	-	-	3713_12:51449713-51449713 C>T_DFLDIYHAFRKQFHPEIISYLEKVI	0.0
17:3585214-3585214 C>T	0.0	4346	COLORECTAL	-	-	-	-	P2RX5	ENST00000550383,p.R347H|NM_002561,p.R347H|ENST00000345901,p.R323H|uc002fwi.3,p.R347H|ENST00000551178,p.R322H|NM_175080,p.R322H|NM_001204520,p.R323H|ENST00000225328,p.R347H|uc002fwj.3,p.R322H|ENST00000435558,p.R347H|ENST00000547178,p.R346H|ENST00000552276,p.R346H|uc002fwk.3,p.R346H|uc002fwl.3,p.R323H|uc010vrx.2,p.R287H|ENST00000552050,p.R287H|NM_001204519,p.R346H	 processed_transcript,retained_intron, nonsense_mediated_decay, protein_coding	uc010vrx.2	nonsynonymous SNV	exon8	c.G860A	p.R287H	VLIYLIKKREFYRDKKYEEVRGLED	VLIYLIKKREFYHDKKYEEVRGLED	4.0	7.0	-	-	4346_17:3585214-3585214 C>T_VLIYLIKKREFYHDKKYEEVRGLED	0.0
2:95542411-95542411 A>T	0.0	4238	COLORECTAL	-	-	-	-	TEKT4	uc002stw.1,p.K402M|NM_001286559,p.K220M|NM_144705,p.K402M|ENST00000295201,p.K402M	retained_intron, protein_coding	uc002stw.1	nonsynonymous SNV	exon6	c.A1205T	p.K402M	LRNLEDIHMSLEKDIAAMTNSLFID	LRNLEDIHMSLEMDIAAMTNSLFID	1.0	2.0	-	-	4238_2:95542411-95542411 A>T_LRNLEDIHMSLEMDIAAMTNSLFID	0.0
17:78346883-78346883 G>T	1.0	4234	NSCLC	-	-	-	1	RNF213	ENST00000582970,p.R4287L|ENST00000336301,p.R2360L|uc021uen.2,p.R4287L|ENST00000508628,p.R4336L|NM_001256071,p.R4287L	retained_intron, protein_coding, processed_transcript	uc021uen.2	nonsynonymous SNV	exon49	c.G12860T	p.R4287L	HRVYLVRKLSSQRGMEFVQGLSKPG	HRVYLVRKLSSQLGMEFVQGLSKPG	9.0	9.0	-	-	4234_17:78346883-78346883 G>T_HRVYLVRKLSSQLGMEFVQGLSKPG	0.0
1:178389736-178389736 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1689278,COSM1689277,COSM1689279;OCCURENCE=1(skin)	-	RASAL2	uc001glq.3,p.L219F|ENST00000462775,p.L71F|NM_170692,p.L219F|NM_004841,p.L71F|ENST00000448150,p.L201F|uc001glr.3,p.L71F|ENST00000367649,p.L219F	retained_intron, protein_coding, processed_transcript	uc001glr.3	nonsynonymous SNV	exon3	c.C211T	p.L71F	KLDRNTSFRLPSLRSTDDRSRGLPK	KLDRNTSFRLPSFRSTDDRSRGLPK	5.0	9.0	-	-	3713_1:178389736-178389736 C>T_KLDRNTSFRLPSFRSTDDRSRGLPK	0.0
4:23815998-23815998 C>T	1.0	2369	MELANOMA	-	-	-	-	PPARGC1A	uc031sdz.1,p.E358K|uc003gqs.3,p.E370K|uc031seb.1,p.E375K|NM_013261,p.E370K|ENST00000264867,p.E370K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031seb.1	nonsynonymous SNV	exon9	c.G1123A	p.E375K	LSKSSVLTGGHEERKTKRPSLRLFG	LSKSSVLTGGHEKRKTKRPSLRLFG	8.0	7.0	-	-	2369_4:23815998-23815998 C>T_LSKSSVLTGGHEKRKTKRPSLRLFG	0.0
19:23844919-23844919 G>A	1.0	3919	MELANOMA	-	-	-	-	ZNF675	ENST00000359788,p.P75S|NM_138330,p.P75S|uc002nri.3,p.P75S	retained_intron, protein_coding, nonsense_mediated_decay	uc002nri.3	nonsynonymous SNV	exon3	c.C223T	p.P75S	LTVKRHEMVNEPPVMCSHFAQEFWP	LTVKRHEMVNEPSVMCSHFAQEFWP	3.0	4.0	-	-	3919_19:23844919-23844919 G>A_LTVKRHEMVNEPSVMCSHFAQEFWP	0.0
3:130098701-130098701 G>T	0.0	4284	COLORECTAL	-	-	-	-	COL6A5	ENST00000432398,p.A370S|NM_153264,p.A370S|ENST00000265379,p.A370S|uc010htj.2,p.A370S|uc010htk.2,p.A370S|ENST00000312481,p.A370S|NM_001278298,p.A370S	protein_coding, nonsense_mediated_decay	uc010htk.2	nonsynonymous SNV	exon4	c.G1108T	p.A370S	ALNLRLEDVNVFALSIQGANNTQLE	ALNLRLEDVNVFSLSIQGANNTQLE	4.0	5.0	-	-	4284_3:130098701-130098701 G>T_ALNLRLEDVNVFSLSIQGANNTQLE	0.0
19:6697537-6697537 A>T	1.0	4126	NSCLC	-	-	-	-	C3	uc002mfm.3,p.F872I|ENST00000245907,p.F872I|NM_000064,p.F872I	retained_intron, protein_coding, processed_transcript	uc002mfm.3	nonsynonymous SNV	exon21	c.T2614A	p.F872I	LKVRVELLHNPAFCSLATTKRRHQQ	LKVRVELLHNPAICSLATTKRRHQQ	10.0	8.0	-	-	4126_19:6697537-6697537 A>T_LKVRVELLHNPAICSLATTKRRHQQ	0.0
19:18965940-18965940 C>T	1.0	3879	MELANOMA	-	-	-	-	UPF1	uc002nkf.3,p.A478V|uc002nkg.3,p.A489V|NM_002911,p.A478V|ENST00000599848,p.A489V|ENST00000262803,p.A478V|NM_001297549,p.A489V	retained_intron, protein_coding, processed_transcript	uc002nkg.3	nonsynonymous SNV	exon11	c.C1466T	p.A489V	QGLPDLNHSQVYAVKTVLQRPLSLI	QGLPDLNHSQVYVVKTVLQRPLSLI	8.0	5.0	-	-	3879_19:18965940-18965940 C>T_QGLPDLNHSQVYVVKTVLQRPLSLI	0.0
2:136873034-136873034 A>G	0.0	4126	NSCLC	-	-	-	1	CXCR4	uc002tuy.3,p.V159A|ENST00000409817,p.V159A|uc002tuz.3,p.V155A|ENST00000241393,p.V155A|uc010fnk.3,p.V140A|NM_003467,p.V155A|NM_001008540,p.V159A	protein_coding, processed_transcript	uc010fnk.3	nonsynonymous SNV	exon2	c.T419C	p.V140A	NSQRPRKLLAEKVVYVGVWIPALLL	NSQRPRKLLAEKAVYVGVWIPALLL	8.0	1.0	-	-	4126_2:136873034-136873034 A>G_NSQRPRKLLAEKAVYVGVWIPALLL	0.0
3:120489701-120489701 G>A	1.0	4284	COLORECTAL	-	-	-	-	GTF2E1	ENST00000469772,p.R25Q|uc003edz.4,p.R192Q|ENST00000283875,p.R192Q|NM_005513,p.R192Q	retained_intron, protein_coding	uc003edz.4	nonsynonymous SNV	exon3	c.G575A	p.R192Q	FNEQIEPIYALLRETEDVNLAYEIL	FNEQIEPIYALLQETEDVNLAYEIL	9.0	5.0	-	-	4284_3:120489701-120489701 G>A_FNEQIEPIYALLQETEDVNLAYEIL	0.0
9:79820249-79820249 C>T	1.0	3716	MELANOMA	-	-	-	-	VPS13A	ENST00000376636,p.P70S|uc004akp.4,p.P70S|NM_001018037,p.P70S|NM_033305,p.P70S|ENST00000376634,p.P70S|uc004akq.4,p.P70S|uc004akr.3,p.P70S|ENST00000357409,p.P70S|NM_015186,p.P70S|ENST00000360280,p.P70S|uc004aks.3,p.P70S|NM_001018038,p.P70S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004aks.3	nonsynonymous SNV	exon4	c.C208T	p.P70S	KVGHIGNLKLIIPWKNLYTQPVEAV	KVGHIGNLKLIISWKNLYTQPVEAV	7.0	6.0	-	-	3716_9:79820249-79820249 C>T_KVGHIGNLKLIISWKNLYTQPVEAV	0.0
15:54557693-54557693 T>A	0.0	4326	BREAST	-	-	-	-	UNC13C	uc021smr.1,p.F1271I	retained_intron, protein_coding	uc021smr.1	nonsynonymous SNV	exon8	c.T3811A	p.F1271I	IFGNLNPVWDEKFYFECHNSTDRIK	IFGNLNPVWDEKIYFECHNSTDRIK	3.0	3.0	-	-	4326_15:54557693-54557693 T>A_IFGNLNPVWDEKIYFECHNSTDRIK	0.0
20:46365584-46365584 G>A	1.0	3919	MELANOMA	-	-	-	-	SULF2	uc002xto.3,p.S93F|NM_001161841,p.S93F|ENST00000361612,p.S93F|ENST00000437955,p.S93F|ENST00000467815,p.S93F|ENST00000359930,p.S93F|uc002xtr.3,p.S93F|NM_018837,p.S93F|uc010ghv.1,p.S93F|ENST00000484875,p.S93F|NM_198596,p.S93F|uc002xtq.3,p.S93F	retained_intron, protein_coding, processed_transcript	uc010ghv.1	nonsynonymous SNV	exon3	c.C278T	p.S93F	AFVTTPMCCPSRSSILTGKYVHNHN	AFVTTPMCCPSRFSILTGKYVHNHN	4.0	7.0	-	-	3919_20:46365584-46365584 G>A_AFVTTPMCCPSRFSILTGKYVHNHN	0.0
9:117819464-117819464 C>T	0.0	4320	COLORECTAL	-	-	-	2	TNC	ENST00000535648,p.R1152Q|NM_002160,p.R1516Q|ENST00000341037,p.R1425Q|ENST00000340094,p.R1152Q|ENST00000350763,p.R1516Q|uc004bjj.4,p.R1516Q	protein_coding, processed_transcript	uc004bjj.4	nonsynonymous SNV	exon15	c.G4547A	p.R1516Q	FIVYLSGLAPSIRTKTISATATTEA	FIVYLSGLAPSIQTKTISATATTEA	8.0	7.0	-	-	4320_9:117819464-117819464 C>T_FIVYLSGLAPSIQTKTISATATTEA	0.0
17:7578406-7578406 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM3355994,COSM1640851,COSM99024,COSM99023,COSM10648,COSM99914,COSM99022;OCCURENCE=4(skin),97(breast),9(biliary_tract),321(large_intestine),4(prostate),4(kidney),9(liver),22(pancreas),28(urinary_tract),1(adrenal_gland),65(ovary),1(soft_tissue),9(endometrium),2(salivary_gland),1(penis),18(lung),2(thyroid),35(haematopoietic_and_lymphoid_tissue),4(cervix),62(stomach),70(central_nervous_system),80(oesophagus),2(vulva),3(bone),51(upper_aerodigestive_tract)	1	TP53	NM_001126118,p.R136H|ENST00000420246,p.R175H|NM_001126112,p.R175H|uc010vug.3,p.R136H|ENST00000455263,p.R175H|ENST00000445888,p.R175H|uc002gio.3,p.R43H|ENST00000413465,p.R175H|NM_001126114,p.R175H|uc002gin.3,p.R82H|NM_001276760,p.R136H|uc010cnf.2,p.R16H|NM_001126115,p.R43H|uc010cng.2,p.R16H|NM_001126117,p.R43H|NM_001276699,p.R16H|uc002gig.1,p.R175H|NM_001276698,p.R16H|NM_000546,p.R175H|uc002gij.3,p.R136H|ENST00000514944,p.R82H|NM_001276761,p.R136H|ENST00000509690,p.R43H|NM_001126116,p.R43H|NM_001126113,p.R175H|NM_001276697,p.R16H|ENST00000269305,p.R175H|NM_001276695,p.R136H|uc002gih.3,p.R175H|ENST00000359597,p.R175H|NM_001276696,p.R136H|uc002gii.2,p.R16H|uc031qyq.1,p.R136H	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon4	c.G407A	p.R136H	YKQSQHMTEVVRRCPHHERCSDSDG	YKQSQHMTEVVRHCPHHERCSDSDG	10.0	10.0	CD8	-	4196_17:7578406-7578406 C>T_YKQSQHMTEVVRHCPHHERCSDSDG	1.0
1:118693198-118693198 G>T	0.0	4259	COLORECTAL	-	-	-	-	SPAG17	ENST00000336338,p.P95T|NM_206996,p.P95T|uc001ehk.2,p.P95T	protein_coding, processed_transcript	uc001ehk.2	nonsynonymous SNV	exon3	c.C283A	p.P95T	LVGSASSKKAKKPVGGNAPLYYEVL	LVGSASSKKAKKTVGGNAPLYYEVL	4.0	5.0	-	-	4259_1:118693198-118693198 G>T_LVGSASSKKAKKTVGGNAPLYYEVL	0.0
1:236189262-236189262 C>T	0.0	4275	COLORECTAL	-	-	-	-	NID1	ENST00000366595,p.V640I|ENST00000264187,p.V640I|uc009xgd.3,p.V640I|uc001hxo.3,p.V640I|NM_002508,p.V640I	protein_coding	uc009xgd.3	nonsynonymous SNV	exon8	c.G1918A	p.V640I	PSTQQLSVDSVFVLYNQEEKILRYA	PSTQQLSVDSVFILYNQEEKILRYA	6.0	5.0	-	-	4275_1:236189262-236189262 C>T_PSTQQLSVDSVFILYNQEEKILRYA	0.0
19:35979706-35979706 C>T	1.0	4244	COLORECTAL	-	-	-	-	KRTDAP	ENST00000484218,p.E42K|NM_001244847,p.E42K|uc021uso.1,p.E42K	protein_coding, processed_transcript	uc021uso.1	nonsynonymous SNV	exon2	c.G124A	p.E42K	EESTIENYASRPEAFKADEFLNWHA	EESTIENYASRPKAFKADEFLNWHA	5.0	6.0	-	-	4244_19:35979706-35979706 C>T_EESTIENYASRPKAFKADEFLNWHA	0.0
9:113197602-113197602 C>T	1.0	3713	MELANOMA	-	-	-	-	SVEP1	uc010mtz.3,p.G1603R|ENST00000374469,p.G1580R|ENST00000401783,p.G1603R|NM_153366,p.G1603R	protein_coding, processed_transcript	uc010mtz.3	nonsynonymous SNV	exon29	c.G4807A	p.G1603R	SLATSCPEELSKGNVLAWPDFLSGI	SLATSCPEELSKRNVLAWPDFLSGI	2.0	8.0	-	-	3713_9:113197602-113197602 C>T_SLATSCPEELSKRNVLAWPDFLSGI	0.0
4:146475155-146475155 T>G	1.0	4335	COLORECTAL	-	-	-	-	SMAD1	ENST00000515385,p.L406R|uc003ikc.3,p.L406R|ENST00000394092,p.L406R|NM_005900,p.L406R|uc003ikd.3,p.L406R|uc011cic.2,p.L367R|ENST00000302085,p.L406R|uc010iov.3,p.L406R|NM_001003688,p.L406R	retained_intron, protein_coding, processed_transcript	uc011cic.2	nonsynonymous SNV	exon4	c.T1100G	p.L367R	QSVNHGFETVYELTKMCTIRMSFVK	QSVNHGFETVYERTKMCTIRMSFVK	9.0	5.0	-	-	4335_4:146475155-146475155 T>G_QSVNHGFETVYERTKMCTIRMSFVK	0.0
1:247464342-247464342 A>C	1.0	4335	COLORECTAL	-	-	-	-	ZNF496	uc009xgv.3,p.F451V|uc001ico.3,p.F415V|ENST00000294753,p.F415V|NM_032752,p.F415V|ENST00000366498,p.F451V|ENST00000461277,p.F340V	protein_coding, processed_transcript	uc009xgv.3	nonsynonymous SNV	exon8	c.T1351G	p.F451V	KKSYVCPNCGKIFRWRVNFIRHLRS	KKSYVCPNCGKIVRWRVNFIRHLRS	9.0	1.0	-	-	4335_1:247464342-247464342 A>C_KKSYVCPNCGKIVRWRVNFIRHLRS	0.0
3:102175092-102175092 G>A	0.0	3795	MELANOMA	-	-	ID=COSM110357;OCCURENCE=1(skin)	-	ZPLD1	uc003dvs.1,p.G128E|NM_175056,p.G144E|ENST00000306176,p.G144E|ENST00000491959,p.G128E|uc003dvt.1,p.G144E|uc011bhg.1,p.G128E|ENST00000466937,p.G128E	protein_coding, processed_transcript	uc011bhg.1	nonsynonymous SNV	exon5	c.G383A	p.G128E	VSAYGNATSVQVGNISGYIDTPDPP	VSAYGNATSVQVENISGYIDTPDPP	1.0	8.0	-	-	3795_3:102175092-102175092 G>A_VSAYGNATSVQVENISGYIDTPDPP	0.0
3:113667758-113667758 C>T	1.0	3713	MELANOMA	-	-	-	-	ZDHHC23	uc003eav.3,p.H31Y|NM_173570,p.H37Y|ENST00000491556,p.H37Y|ENST00000478793,p.H37Y|uc003eau.3,p.H37Y|ENST00000498275,p.H31Y|ENST00000330212,p.H37Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc003eav.3	nonsynonymous SNV	exon3	c.C91T	p.H31Y	CCEYIDRNGEKNHVATCLCDCQDLD	CCEYIDRNGEKNYVATCLCDCQDLD	3.0	1.0	-	-	3713_3:113667758-113667758 C>T_CCEYIDRNGEKNYVATCLCDCQDLD	0.0
13:113899523-113899523 C>T	1.0	3713	MELANOMA	-	-	-	-	CUL4A	uc021rmu.1,p.S401L|NM_001278514,p.S409L|ENST00000375440,p.S501L|ENST00000451881,p.S401L|uc010agu.3,p.S362L|NM_003589,p.S401L|uc021rmv.1,p.S501L|NM_001278513,p.S401L|ENST00000375441,p.S401L|ENST00000326335,p.S401L|NM_001008895,p.S501L|uc010tjz.2,p.S180L	protein_coding, processed_transcript	uc021rmv.1	nonsynonymous SNV	exon14	c.C1502T	p.S501L	SKLEGMFKDMELSKDIMVHFKQHMQ	SKLEGMFKDMELLKDIMVHFKQHMQ	9.0	3.0	-	-	3713_13:113899523-113899523 C>T_SKLEGMFKDMELLKDIMVHFKQHMQ	0.0
7:5967982-5967982 G>T	1.0	4252	COLORECTAL	-	-	-	-	RSPH10B,RSPH10B2	uc011jwk.2,p.T381K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jwk.2	nonsynonymous SNV	exon11	c.C1142A	p.T381K	MRDPRMIERKSSTRGSIICTSSL	MRDPRMIERKSSKRGSIICTSSL	5.0	6.0	-	-	4252_7:5967982-5967982 G>T_MRDPRMIERKSSKRGSIICTSSL	0.0
1:94586549-94586549 C>T	0.0	2359	MELANOMA	-	-	-	-	ABCA4	ENST00000535735,p.R18Q|ENST00000370225,p.R18Q|uc001dqh.3,p.R18Q|uc010otn.1,p.R18Q|NM_000350,p.R18Q	protein_coding, processed_transcript	uc010otn.1	nonsynonymous SNV	exon1	c.G53A	p.R18Q	QIQLLLWKNWTLRKRQKIRFVVELV	QIQLLLWKNWTLQKRQKIRFVVELV	2.0	9.0	-	-	2359_1:94586549-94586549 C>T_QIQLLLWKNWTLQKRQKIRFVVELV	0.0
2:196834709-196834709 T>C	1.0	4078	GASTRIC	-	-	-	-	DNAH7	ENST00000312428,p.Q723R|NM_018897,p.Q723R|uc002utj.4,p.Q723R	retained_intron, protein_coding, processed_transcript	uc002utj.4	nonsynonymous SNV	exon17	c.A2168G	p.Q723R	DLQDVQRYLKKAQILNGKLDLAADK	DLQDVQRYLKKARILNGKLDLAADK	3.0	8.0	-	-	4078_2:196834709-196834709 T>C_DLQDVQRYLKKARILNGKLDLAADK	0.0
6:114378489-114378489 G>A	0.0	4240	BREAST	-	-	ID=COSM1072326;OCCURENCE=2(endometrium),1(large_intestine)	-	HS3ST5	ENST00000312719,p.R325C|NM_153612,p.R325C|ENST00000411826,p.R325C|uc003pwh.4,p.R325C|uc003pwg.4,p.R325C	protein_coding, processed_transcript	uc003pwh.4	nonsynonymous SNV	exon5	c.C973T	p.R325C	HPEVDPSVITKLRKFFHPFNQKFYQ	HPEVDPSVITKLCKFFHPFNQKFYQ	3.0	5.0	-	-	4240_6:114378489-114378489 G>A_HPEVDPSVITKLCKFFHPFNQKFYQ	0.0
11:34120900-34120902 CAG>-	1.0	4196	COLORECTAL	-	-	-	-	CAPRIN1	uc001mvh.1,p.706_706del|uc001mvj.1,p.625_625del|uc001mvi.2,p.706_706del|ENST00000529307,p.625_625del|ENST00000341394,p.706_706del|NM_005898,p.706_706del|ENST00000532820,p.706_706del	protein_coding, processed_transcript, nonsense_mediated_decay	uc001mvj.1	nonframeshift deletion	exon18	c.1873_1875del	p.625_625del	PRPNRGMPQMNTQQVN	PRPNRGMPQMNTQVN	10.0	8.0	-	-	4196_11:34120900-34120902 CAG>-_PRPNRGMPQMNTQVN	0.0
6:37618104-37618104 C>T	1.0	3466	MELANOMA	-	-	-	-	MDGA1	NM_153487,p.E464K|uc003onu.1,p.E464K|ENST00000297153,p.E464K|ENST00000434837,p.E464K|ENST00000505425,p.E464K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003onu.1	nonsynonymous SNV	exon8	c.G1390A	p.E464K	TVREGSPAELQCEVRGKPRPPVLWS	TVREGSPAELQCKVRGKPRPPVLWS	5.0	9.0	-	-	3466_6:37618104-37618104 C>T_TVREGSPAELQCKVRGKPRPPVLWS	0.0
14:74062281-74062281 G>C	0.0	4134	NSCLC	-	-	-	-	ACOT4	ENST00000326303,p.D397H|NM_152331,p.D397H|uc001xoo.3,p.D397H	protein_coding	uc001xoo.3	nonsynonymous SNV	exon3	c.G1189C	p.D397H	GGEPRAHSKAQEDAWKQILAFFCKH	GGEPRAHSKAQEHAWKQILAFFCKH	6.0	7.0	-	-	4134_14:74062281-74062281 G>C_GGEPRAHSKAQEHAWKQILAFFCKH	0.0
1:75037109-75037109 C>A	0.0	4246	COLORECTAL	-	-	-	-	ERICH3	ENST00000326665,p.A1429S|uc001dgg.3,p.A1429S|NM_001002912,p.A1429S	protein_coding, processed_transcript	uc001dgg.3	nonsynonymous SNV	exon14	c.G4285T	p.A1429S	AAEEMTVTYTTEAGVGTPGALERKT	AAEEMTVTYTTESGVGTPGALERKT	2.0	4.0	-	-	4246_1:75037109-75037109 C>A_AAEEMTVTYTTESGVGTPGALERKT	0.0
17:30520173-30520173 C>T	0.0	3795	MELANOMA	-	-	-	-	RHOT1	uc002hgz.3,p.P220S|NM_001288758,p.P93S|uc010wby.2,p.P220S|ENST00000358365,p.P220S|ENST00000545287,p.P220S|NM_001033566,p.P220S|uc002hgy.3,p.P220S|NM_001288755,p.P199S|ENST00000581031,p.P220S|uc002hgv.3,p.P220S|uc002hgx.3,p.P93S|ENST00000583994,p.P93S|uc002hha.3,p.P93S|ENST00000394692,p.P220S|NM_001288754,p.P220S|NM_001033567,p.P93S|NM_018307,p.P220S|uc002hhb.3,p.P199S|ENST00000581094,p.P220S|NM_001033568,p.P220S|uc002hgw.3,p.P220S|ENST00000354266,p.P199S|ENST00000333942,p.P220S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wby.2	nonsynonymous SNV	exon10	c.C658T	p.P220S	ELNFFQRICFNTPLAPQALEDVKNV	ELNFFQRICFNTSLAPQALEDVKNV	9.0	10.0	-	-	3795_17:30520173-30520173 C>T_ELNFFQRICFNTSLAPQALEDVKNV	0.0
11:5809851-5809851 C>T	0.0	4284	COLORECTAL	-	-	-	-	OR52N1	ENST00000317078,p.A66T|NM_001001913,p.A66T|uc010qzo.2,p.A66T	protein_coding	uc010qzo.2	nonsynonymous SNV	exon1	c.G196A	p.A66T	DEALHRPMYVFLALLSFTDVLMCTS	DEALHRPMYVFLTLLSFTDVLMCTS	2.0	9.0	-	-	4284_11:5809851-5809851 C>T_DEALHRPMYVFLTLLSFTDVLMCTS	0.0
11:70319055-70319055 C>G	1.0	4078	GASTRIC	-	-	-	-	SHANK2	ENST00000424924,p.E1102D|ENST00000338508,p.E1824D|uc001opy.3,p.E159D|ENST00000449833,p.E1228D|ENST00000409161,p.E1227D|ENST00000423696,p.E1444D|uc001opz.3,p.E1228D|ENST00000294018,p.E1447D|NM_133266,p.E1235D	protein_coding, processed_transcript	uc001opz.3	nonsynonymous SNV	exon10	c.G3684C	p.E1228D	EIDGSHLPNLQKEDLIDLGVTRVGH	EIDGSHLPNLQKDDLIDLGVTRVGH	10.0	9.0	-	-	4078_11:70319055-70319055 C>G_EIDGSHLPNLQKDDLIDLGVTRVGH	0.0
8:109240562-109240562 A>C	1.0	2591	MELANOMA	-	-	-	1	EIF3E	uc003ymu.3,p.L219R|NM_001568,p.L219R|ENST00000220849,p.L219R|ENST00000519030,p.L126R|ENST00000519627,p.L92R|uc003ymt.3,p.L170R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ymu.3	nonsynonymous SNV	exon7	c.T656G	p.L219R	SLQQRTWLIHWSLFVFFNHPKGRDN	SLQQRTWLIHWSRFVFFNHPKGRDN	10.0	1.0	-	-	2591_8:109240562-109240562 A>C_SLQQRTWLIHWSRFVFFNHPKGRDN	0.0
10:15256395-15256395 G>A	0.0	3903	MELANOMA	-	-	-	-	FAM171A1	ENST00000378116,p.H398Y|NM_001010924,p.H398Y|uc001iob.3,p.H398Y	protein_coding, processed_transcript	uc001iob.3	nonsynonymous SNV	exon8	c.C1192T	p.H398Y	EAPGTKELMSGVHLEMMSPGGEGDL	EAPGTKELMSGVYLEMMSPGGEGDL	4.0	9.0	-	-	3903_10:15256395-15256395 G>A_EAPGTKELMSGVYLEMMSPGGEGDL	0.0
5:178548703-178548703 G>A	1.0	3713	MELANOMA	-	-	-	-	ADAMTS2	NM_014244,p.S1046F|uc003mjw.3,p.S1046F|ENST00000251582,p.S1046F	retained_intron, protein_coding	uc003mjw.3	nonsynonymous SNV	exon21	c.C3137T	p.S1046F	DPSKKSYVVQWLSRPDPDSPIRKIS	DPSKKSYVVQWLFRPDPDSPIRKIS	3.0	2.0	-	-	3713_5:178548703-178548703 G>A_DPSKKSYVVQWLFRPDPDSPIRKIS	0.0
2:182780661-182780661 G>C	0.0	4345	COLORECTAL	-	-	-	-	SSFA2	uc002uol.3,p.R612T|uc002uoj.3,p.R765T|NM_001287503,p.R765T|ENST00000409136,p.R274T|ENST00000431877,p.R765T|NM_001130445,p.R765T|uc010zfo.2,p.R612T|NM_006751,p.R765T|uc002uoi.3,p.R765T|ENST00000409001,p.R765T|ENST00000320370,p.R765T|uc002uoh.3,p.R765T|uc002uom.3,p.R233T|NM_001287504,p.R612T|ENST00000428267,p.R612T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zfo.2	nonsynonymous SNV	exon10	c.G1835C	p.R612T	SVNVRLSPGKETRCSPPSFTYKYTP	SVNVRLSPGKETTCSPPSFTYKYTP	10.0	7.0	-	-	4345_2:182780661-182780661 G>C_SVNVRLSPGKETTCSPPSFTYKYTP	0.0
10:119134252-119134252 C>G	1.0	4335	COLORECTAL	-	-	-	-	PDZD8	ENST00000334464,p.V163L|uc001lde.1,p.V163L|NM_173791,p.V163L	protein_coding, processed_transcript	uc001lde.1	nonsynonymous SNV	exon1	c.G487C	p.V163L	GETVPFIKTIRLVRPVVPSATGEPD	GETVPFIKTIRLLRPVVPSATGEPD	7.0	5.0	-	-	4335_10:119134252-119134252 C>G_GETVPFIKTIRLLRPVVPSATGEPD	0.0
12:124163787-124163787 C>T	1.0	3466	MELANOMA	-	-	-	-	TCTN2	ENST00000303372,p.P172L|ENST00000426174,p.P171L|uc001ufp.3,p.P172L|NM_001143850,p.P171L|NM_024809,p.P172L|uc009zya.3,p.P171L	retained_intron, protein_coding, nonsense_mediated_decay	uc009zya.3	nonsynonymous SNV	exon5	c.C512T	p.P171L	IPNQVYQPLGPCPCNLTAGACDVRC	IPNQVYQPLGPCLCNLTAGACDVRC	5.0	9.0	-	-	3466_12:124163787-124163787 C>T_IPNQVYQPLGPCLCNLTAGACDVRC	0.0
3:119112367-119112367 G>T	0.0	4335	COLORECTAL	-	-	ID=COSM359827;OCCURENCE=1(lung)	-	ARHGAP31	NM_020754,p.R312L|uc003ecj.4,p.R312L|ENST00000264245,p.R312L	protein_coding	uc003ecj.4	nonsynonymous SNV	exon8	c.G935T	p.R312L	KSKKWKSIFNLGRSGSDSKSKLSRN	KSKKWKSIFNLGLSGSDSKSKLSRN	9.0	7.0	-	-	4335_3:119112367-119112367 G>T_KSKKWKSIFNLGLSGSDSKSKLSRN	0.0
15:59516972-59516972 G>T	1.0	3775	CERVICAL	-	-	-	-	MYO1E	ENST00000288235,p.S231R|ENST00000559269,p.S61R|uc002aga.4,p.S231R|NM_004998,p.S231R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002aga.4	nonsynonymous SNV	exon8	c.C693A	p.S231R	ASAEQKHSLGITSMDYYYYLSLSGS	ASAEQKHSLGITRMDYYYYLSLSGS	9.0	6.0	-	-	3775_15:59516972-59516972 G>T_ASAEQKHSLGITRMDYYYYLSLSGS	0.0
8:11607630-11607630 G>A	0.0	4287	COLORECTAL	-	-	ID=COSM1454350;OCCURENCE=1(large_intestine)	-	GATA4	uc011kxc.1,p.R266H|uc003wub.1,p.R59H|ENST00000528712,p.R59H|ENST00000526716,p.R59H|ENST00000335135,p.R265H|NM_002052,p.R265H|ENST00000532059,p.R266H|uc003wuc.2,p.R265H	retained_intron, protein_coding, processed_transcript	uc011kxc.1	nonsynonymous SNV	exon3	c.G797A	p.R266H	PLIKPQRRLSASRRVGLSCANCQTT	PLIKPQRRLSASHRVGLSCANCQTT	1.0	10.0	-	-	4287_8:11607630-11607630 G>A_PLIKPQRRLSASHRVGLSCANCQTT	0.0
1:31350055-31350055 G>A	1.0	3678	MELANOMA	-	-	-	-	SDC3	uc001bsd.2,p.P14S|ENST00000336798,p.P14S	protein_coding, processed_transcript	uc001bsd.2	nonsynonymous SNV	exon1	c.C40T	p.P14S	AIAYLGSSCPSQPPSSLALSLSPTP	AIAYLGSSCPSQSPSSLALSLSPTP	9.0	10.0	-	-	3678_1:31350055-31350055 G>A_AIAYLGSSCPSQSPSSLALSLSPTP	0.0
6:143074519-143074519 C>T	1.0	2556	MELANOMA	-	-	-	-	HIVEP2	ENST00000367603,p.E2356K|ENST00000367604,p.E2356K|ENST00000012134,p.E2356K|NM_006734,p.E2356K|uc003qjd.3,p.E2356K	protein_coding, processed_transcript	uc003qjd.3	nonsynonymous SNV	exon10	c.G7066A	p.E2356K	ALLGPDQPARVQEPHQNPLGSAHVS	ALLGPDQPARVQKPHQNPLGSAHVS	6.0	8.0	-	-	2556_6:143074519-143074519 C>T_ALLGPDQPARVQKPHQNPLGSAHVS	0.0
10:19620486-19620486 T>A	0.0	3795	MELANOMA	-	-	-	-	MALRD1	ENST00000377266,p.N601K|NM_001142308,p.N1292K|ENST00000454679,p.N588K	protein_coding, processed_transcript	NM_001142308	nonsynonymous SNV	exon24	c.T3876A	p.N1292K	DKLCDFVNDCADNSDETTFICRTSS	DKLCDFVNDCADKSDETTFICRTSS	1.0	9.0	-	-	3795_10:19620486-19620486 T>A_DKLCDFVNDCADKSDETTFICRTSS	0.0
9:114199371-114199371 G>A	1.0	4136	BREAST	-	-	-	-	KIAA0368	ENST00000259335,p.S364F|uc004bfe.1,p.S364F|ENST00000602447,p.S192F|uc010muc.1,p.S186F|NM_001080398,p.S364F|ENST00000338205,p.S186F	protein_coding, processed_transcript	uc010muc.1	nonsynonymous SNV	exon7	c.C557T	p.S186F	VLLMPYGYVLNESQSRQNSSSAQGS	VLLMPYGYVLNEFQSRQNSSSAQGS	10.0	4.0	CD8	-	4136_9:114199371-114199371 G>A_VLLMPYGYVLNEFQSRQNSSSAQGS	1.0
7:49815341-49815341 G>A	0.0	4160	COLORECTAL	-	-	-	-	VWC2	uc003tot.1,p.A104T|ENST00000340652,p.A104T|NM_198570,p.A104T	protein_coding	uc003tot.1	nonsynonymous SNV	exon2	c.G310A	p.A104T	KLKQAWVSQGGGAKAGDLQVRPRGD	KLKQAWVSQGGGTKAGDLQVRPRGD	1.0	2.0	-	-	4160_7:49815341-49815341 G>A_KLKQAWVSQGGGTKAGDLQVRPRGD	0.0
16:24580388-24580388 C>T	1.0	3795	MELANOMA	-	-	-	-	RBBP6	uc002dmk.3,p.R626C|uc002dmi.3,p.R759C|uc010vcb.1,p.R660C|uc002dmh.3,p.R793C|ENST00000319715,p.R793C|ENST00000348022,p.R759C|ENST00000564314,p.R660C|NM_006910,p.R793C|NM_018703,p.R759C	retained_intron, protein_coding	uc010vcb.1	nonsynonymous SNV	exon15	c.C1978T	p.R660C	PNKRNVPQGETEREYFNRYREVPPP	PNKRNVPQGETECEYFNRYREVPPP	10.0	6.0	CD8	-	3795_16:24580388-24580388 C>T_PNKRNVPQGETECEYFNRYREVPPP	1.0
4:113353153-113353153 C>A	1.0	3716	MELANOMA	-	-	-	-	ALPK1	NM_025144,p.P817Q|uc011cfx.2,p.P739Q|ENST00000504176,p.P739Q|ENST00000458497,p.P817Q|uc003iap.4,p.P817Q|uc010imo.3,p.P645Q|ENST00000177648,p.P817Q|NM_001102406,p.P817Q|uc003ian.4,p.P817Q|NM_001253884,p.P739Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cfx.2	nonsynonymous SNV	exon10	c.C2216A	p.P739Q	VLHNSLGNISMLPCSSFTPNWPVQN	VLHNSLGNISMLQCSSFTPNWPVQN	9.0	3.0	-	-	3716_4:113353153-113353153 C>A_VLHNSLGNISMLQCSSFTPNWPVQN	0.0
5:74930784-74930784 T>C	0.0	3903	MELANOMA	-	-	-	-	ANKDD1B	uc031ski.1,p.L221P|ENST00000601380,p.L221P|NM_001276713,p.L221P	retained_intron, protein_coding, processed_transcript	uc031ski.1	nonsynonymous SNV	exon6	c.T662C	p.L221P	AAERGHVEMIEKLTFLNLHTSEKDK	AAERGHVEMIEKPTFLNLHTSEKDK	3.0	3.0	-	-	3903_5:74930784-74930784 T>C_AAERGHVEMIEKPTFLNLHTSEKDK	0.0
1:248525559-248525559 T>G	0.0	4213	COLORECTAL	-	-	-	-	OR2T4	NM_001004696,p.L226R|ENST00000366475,p.L226R|uc001ieh.1,p.L226R	protein_coding	uc001ieh.1	nonsynonymous SNV	exon1	c.T677G	p.L226R	PAVLNLSCSDTSLYEIFMYLCCVLM	PAVLNLSCSDTSRYEIFMYLCCVLM	1.0	5.0	-	-	4213_1:248525559-248525559 T>G_PAVLNLSCSDTSRYEIFMYLCCVLM	0.0
7:50132748-50132748 G>C	0.0	4081	COLORECTAL	-	-	-	-	ZPBP	uc010kyw.3,p.R15G|ENST00000046087,p.R15G|ENST00000413331,p.R15G|uc003tou.3,p.R15G|NM_001159878,p.R15G|NM_007009,p.R15G|ENST00000419417,p.R15G	protein_coding, processed_transcript, nonsense_mediated_decay	uc010kyw.3	nonsynonymous SNV	exon1	c.C43G	p.R15G	AFALGPARRGRRRTRAAGSLLSRAA	AFALGPARRGRRGTRAAGSLLSRAA	1.0	6.0	-	-	4081_7:50132748-50132748 G>C_AFALGPARRGRRGTRAAGSLLSRAA	0.0
16:2258780-2258780 C>T	1.0	3713	MELANOMA	-	-	-	-	MLST8	ENST00000569417,p.R295W|NM_001199174,p.R295W|ENST00000565250,p.R295W|uc002cpf.3,p.R295W|uc002cpb.3,p.R294W|NM_001199173,p.R295W|uc002cpe.3,p.R295W|ENST00000397124,p.R295W|ENST00000564088,p.R295W|uc010uvx.2,p.R229W|NM_001199175,p.R294W|ENST00000382450,p.R294W|uc002cpc.3,p.R295W|uc002coz.3,p.R295W|uc002cpd.3,p.R229W|NM_022372,p.R295W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uvx.2	nonsynonymous SNV	exon8	c.C685T	p.R229W	QYIVTASSDNLARLWCVETGEIKRE	QYIVTASSDNLAWLWCVETGEIKRE	8.0	2.0	-	-	3713_16:2258780-2258780 C>T_QYIVTASSDNLAWLWCVETGEIKRE	0.0
3:183906916-183906916 C>T	1.0	4189	MELANOMA	0.0005	-	-	-	ABCF3	uc003fnb.2,p.R21W|uc003fmz.2,p.R340W|ENST00000292808,p.R334W|NM_018358,p.R340W|ENST00000429586,p.R340W|uc003fna.2,p.R334W	retained_intron, protein_coding, nonsense_mediated_decay	uc003fnb.2	nonsynonymous SNV	exon3	c.C61T	p.R21W	FSGGWRMRLALARALFARPDLLLLD	FSGGWRMRLALAWALFARPDLLLLD	9.0	9.0	-	-	4189_3:183906916-183906916 C>T_FSGGWRMRLALAWALFARPDLLLLD	0.0
X:148664778-148664778 C>T	0.0	3795	MELANOMA	-	-	ID=COSM3843840;OCCURENCE=1(breast)	-	MAGEA9,MAGEA9B	NM_001080790,p.G20R|NM_005365,p.G20R|uc004fdk.3,p.G20R|uc022cgj.1,p.G20R|ENST00000243314,p.G20R	protein_coding	uc022cgj.1	nonsynonymous SNV	exon1	c.G58A	p.G20R	PHCKPDEDLEAQGEDLGLMGAQEPT	PHCKPDEDLEAQREDLGLMGAQEPT	1.0	2.0	-	-	3795_X:148664778-148664778 C>T_PHCKPDEDLEAQREDLGLMGAQEPT	0.0
17:18049218-18049218 T>A	1.0	4287	COLORECTAL	-	-	-	-	MYO15A	uc021trl.1,p.H2100Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021trl.1	nonsynonymous SNV	exon29	c.T6300A	p.H2100Q	IFKLILRFMGDPHLHGARENIFGNY	IFKLILRFMGDPQLHGARENIFGNY	5.0	7.0	-	-	4287_17:18049218-18049218 T>A_IFKLILRFMGDPQLHGARENIFGNY	0.0
16:20432653-20432653 A>T	0.0	3466	MELANOMA	-	-	-	-	ACSM5	ENST00000573920,p.T20S|uc002dhe.3,p.T233S|ENST00000331849,p.T233S|NM_017888,p.T233S	retained_intron, protein_coding, nonsense_mediated_decay	uc002dhe.3	nonsynonymous SNV	exon5	c.A697T	p.T233S	SRDPLAIYFTSGTTGAPKMVEHSQS	SRDPLAIYFTSGSTGAPKMVEHSQS	1.0	4.0	-	-	3466_16:20432653-20432653 A>T_SRDPLAIYFTSGSTGAPKMVEHSQS	0.0
14:24780394-24780394 C>G	0.0	4186	BREAST	-	-	-	-	LTB4R2	uc001wor.3,p.P175R|NM_001164692,p.P175R|NM_019839,p.P175R|ENST00000530080,p.P175R|uc010alo.3,p.P175R|ENST00000543919,p.P175R|uc021rrp.1,p.P175R|ENST00000533293,p.P175R|ENST00000528054,p.P206R	protein_coding	uc021rrp.1	nonsynonymous SNV	exon1	c.C524G	p.P175R	WRDRVCQLCHPSPVHAAAHLSLETL	WRDRVCQLCHPSRVHAAAHLSLETL	5.0	9.0	-	-	4186_14:24780394-24780394 C>G_WRDRVCQLCHPSRVHAAAHLSLETL	0.0
11:95560969-95560969 C>T	1.0	3713	MELANOMA	-	-	-	-	CEP57	uc001pfr.2,p.A150V|NM_014679,p.A302V|NM_001243776,p.A293V|uc010ruh.2,p.A293V|uc001pfp.2,p.A302V|uc009ywn.2,p.A150V|ENST00000537677,p.A275V|ENST00000325542,p.A302V|ENST00000541150,p.A293V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ruh.2	nonsynonymous SNV	exon10	c.C878T	p.A293V	PFVAGKSTSPSHAVVANVQLVLHLM	PFVAGKSTSPSHVVVANVQLVLHLM	8.0	3.0	-	-	3713_11:95560969-95560969 C>T_PFVAGKSTSPSHVVVANVQLVLHLM	0.0
1:198713260-198713260 A>C	0.0	4238	COLORECTAL	-	-	-	1	PTPRC	ENST00000594404,p.L762F|NM_080921,p.L764F|ENST00000352140,p.L875F|uc001gut.2,p.L764F|ENST00000367376,p.L923F|ENST00000442510,p.L925F|uc001gur.2,p.L925F|NM_002838,p.L925F|ENST00000348564,p.L764F	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc001gut.2	nonsynonymous SNV	exon23	c.A2292C	p.L764F	NQFGETEVNLSELHPYLHNMKKRDP	NQFGETEVNLSEFHPYLHNMKKRDP	2.0	1.0	-	-	4238_1:198713260-198713260 A>C_NQFGETEVNLSEFHPYLHNMKKRDP	0.0
12:70963716-70963716 G>A	1.0	3713	MELANOMA	-	-	-	1	PTPRB	uc009zrr.2,p.P1004S|NM_002837,p.P907S|uc001swa.4,p.P1037S|uc001swb.4,p.P907S|NM_001206972,p.P907S|ENST00000550358,p.P1037S|NM_001109754,p.P1125S|uc010stp.2,p.P817S|NM_001206971,p.P817S|ENST00000261266,p.P907S|uc001swd.4,p.P1124S|ENST00000551525,p.P1124S|uc010sto.2,p.P907S|ENST00000548122,p.P1004S|ENST00000538708,p.P907S|ENST00000451516,p.P817S|uc001swc.4,p.P1125S|ENST00000334414,p.P1125S|ENST00000550857,p.P817S	retained_intron, protein_coding, processed_transcript	uc010stp.2	nonsynonymous SNV	exon11	c.C2449T	p.P817S	VQQSAFIEGFTVPSAVKNIHISPNG	VQQSAFIEGFTVSSAVKNIHISPNG	2.0	6.0	-	-	3713_12:70963716-70963716 G>A_VQQSAFIEGFTVSSAVKNIHISPNG	0.0
8:117950717-117950717 G>A	0.0	4160	COLORECTAL	-	-	-	-	AARD	uc003yof.3,p.V79M|NM_001025357,p.V79M|ENST00000378279,p.V79M	protein_coding, processed_transcript	uc003yof.3	nonsynonymous SNV	exon1	c.G235A	p.V79M	FQWAVQRAISRRVQEAAAAAAAREE	FQWAVQRAISRRMQEAAAAAAAREE	1.0	2.0	-	-	4160_8:117950717-117950717 G>A_FQWAVQRAISRRMQEAAAAAAAREE	0.0
6:32800111-32800111 T>C	1.0	3919	MELANOMA	-	-	-	-	TAP2	ENST00000374899,p.Q424R|uc011dqf.1,p.Q424R|uc003ocb.1,p.Q424R|uc003ocd.3,p.Q424R|uc003occ.3,p.Q424R|NM_001290043,p.Q424R|ENST00000452392,p.Q424R|NM_018833,p.Q424R|ENST00000374897,p.Q424R	retained_intron, protein_coding, processed_transcript	uc011dqf.1	nonsynonymous SNV	exon7	c.A1271G	p.Q424R	FMIYQESVGSYVQTLVYIYGDMLSN	FMIYQESVGSYVRTLVYIYGDMLSN	5.0	3.0	-	-	3919_6:32800111-32800111 T>C_FMIYQESVGSYVRTLVYIYGDMLSN	0.0
20:35563433-35563433 C>G	0.0	4335	COLORECTAL	-	-	-	-	SAMHD1	uc002xgh.2,p.G170R|ENST00000262878,p.G170R|NM_015474,p.G170R	retained_intron, protein_coding	uc002xgh.2	nonsynonymous SNV	exon4	c.G508C	p.G170R	PGASHNRFEHSLGVGYLAGCLVHAL	PGASHNRFEHSLRVGYLAGCLVHAL	10.0	7.0	-	-	4335_20:35563433-35563433 C>G_PGASHNRFEHSLRVGYLAGCLVHAL	0.0
1:23219413-23219413 C>T	0.0	2359	MELANOMA	-	-	-	-	EPHB2	ENST00000374632,p.P489S|uc009vqj.1,p.P489S|uc001bgf.3,p.P489S|NM_017449,p.P489S|ENST00000374630,p.P489S|NM_004442,p.P489S|ENST00000374627,p.P484S|uc010odu.2,p.P489S|ENST00000400191,p.P489S|uc001bge.3,p.P489S	protein_coding, processed_transcript	uc010odu.2	nonsynonymous SNV	exon8	c.C1465T	p.P489S	ELSEYNATAIKSPTNTVTVQGLKAG	ELSEYNATAIKSSTNTVTVQGLKAG	3.0	8.0	-	-	2359_1:23219413-23219413 C>T_ELSEYNATAIKSSTNTVTVQGLKAG	0.0
17:7226985-7226985 C>G	1.0	4252	COLORECTAL	-	-	-	-	NEURL4	uc002ggc.1,p.W119C|ENST00000399464,p.W773C|NM_032442,p.W773C|ENST00000573186,p.W518C|ENST00000570460,p.W751C|uc002gga.1,p.W773C|ENST00000315614,p.W773C|uc002ggb.1,p.W773C|NM_001005408,p.W773C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ggc.1	nonsynonymous SNV	exon10	c.G357C	p.W119C	LFEIVIQKMVDRWSGSIEAGVTAIR	LFEIVIQKMVDRCSGSIEAGVTAIR	8.0	9.0	-	-	4252_17:7226985-7226985 C>G_LFEIVIQKMVDRCSGSIEAGVTAIR	0.0
2:180310306-180310306 G>T	0.0	4186	BREAST	-	-	-	-	ZNF385B	NM_152520,p.H356N|NM_001282725,p.H254N|uc002unm.3,p.H280N|NM_001113397,p.H280N|NM_001113398,p.H254N|ENST00000410066,p.H356N|ENST00000336917,p.H254N|uc002unl.4,p.H253N|uc002unn.4,p.H356N|ENST00000409692,p.H254N|ENST00000409343,p.H280N|uc002unj.3,p.H254N	protein_coding, processed_transcript	uc002unn.4	nonsynonymous SNV	exon8	c.C1066A	p.H356N	QNKTFHCEICDVHVNSEIQLKQHIS	QNKTFHCEICDVNVNSEIQLKQHIS	5.0	10.0	-	-	4186_2:180310306-180310306 G>T_QNKTFHCEICDVNVNSEIQLKQHIS	0.0
20:60881767-60881767 G>A	1.0	3466	MELANOMA	-	-	-	-	ADRM1	NM_175573,p.G173E|ENST00000253003,p.G173E|NM_001281437,p.G134E|NM_007002,p.G173E|uc002yco.3,p.G173E|NM_001281438,p.G134E|uc002ycn.3,p.G173E	protein_coding, processed_transcript	uc002yco.3	nonsynonymous SNV	exon5	c.G518A	p.G173E	GNMSHSQLMQLIGPAGLGGLGGLGA	GNMSHSQLMQLIEPAGLGGLGGLGA	8.0	3.0	-	-	3466_20:60881767-60881767 G>A_GNMSHSQLMQLIEPAGLGGLGGLGA	0.0
17:45363729-45363729 C>T	0.0	4278	COLORECTAL	-	-	-	-	ITGB3	ENST00000559488,p.R240W|uc002ilj.3,p.R240W|NM_000212,p.R240W|uc002ili.1,p.R240W|ENST00000435993,p.R193W|ENST00000571680,p.R240W	protein_coding, nonsense_mediated_decay	uc002ilj.3	nonsynonymous SNV	exon5	c.C718T	p.R240W	RFNEEVKKQSVSRNRDAPEGGFDAI	RFNEEVKKQSVSWNRDAPEGGFDAI	7.0	9.0	-	-	4278_17:45363729-45363729 C>T_RFNEEVKKQSVSWNRDAPEGGFDAI	0.0
14:103188564-103188564 C>T	1.0	3784	MELANOMA	-	-	-	-	RCOR1	ENST00000560472,p.T35M	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000560472	nonsynonymous SNV	exon2	c.C104T	p.T35M	SGNMAEIFRQSQT	SGNMAEIFRQSQM	8.0	5.0	-	-	3784_14:103188564-103188564 C>T_SGNMAEIFRQSQM	0.0
11:116707116-116707116 A>G	0.0	4326	BREAST	-	-	-	-	APOA1	uc001ppv.1,p.L71P|ENST00000236850,p.L71P|ENST00000359492,p.L71P|ENST00000375323,p.L71P|NM_000039,p.L71P|ENST00000375320,p.L71P	protein_coding	uc001ppv.1	nonsynonymous SNV	exon4	c.T212C	p.L71P	GSALGKQLNLKLLDNWDSVTSTFSK	GSALGKQLNLKLPDNWDSVTSTFSK	3.0	7.0	-	-	4326_11:116707116-116707116 A>G_GSALGKQLNLKLPDNWDSVTSTFSK	0.0
1:155110536-155110536 T>A	1.0	3678	MELANOMA	-	-	-	-	SLC50A1	ENST00000368404,p.C176S|NM_001287587,p.C169S|NM_001287592,p.C58S|ENST00000368401,p.C121S|uc001fhl.4,p.C122S|uc001fhk.4,p.C121S|NM_001287586,p.C130S|NM_001122837,p.C121S|ENST00000484157,p.C111S|NM_018845,p.C176S|NM_001287591,p.C138S|NM_001122839,p.C122S|NM_001287589,p.C67S|ENST00000303343,p.C122S|NM_001287588,p.C121S|uc001fhj.4,p.C176S|NM_001287590,p.C111S	protein_coding, processed_transcript	uc001fhl.4	nonsynonymous SNV	exon4	c.T364A	p.C122S	LTIATLLTSASWCLYGFRLRDPYIM	LTIATLLTSASWSLYGFRLRDPYIM	8.0	2.0	-	-	3678_1:155110536-155110536 T>A_LTIATLLTSASWSLYGFRLRDPYIM	0.0
17:61086927-61086927 C>T	0.0	4235	COLORECTAL	-	-	-	-	TANC2	uc002jal.4,p.R3W|ENST00000424789,p.R3W|ENST00000389520,p.R3W|NM_025185,p.R3W	retained_intron, protein_coding	uc002jal.4	nonsynonymous SNV	exon1	c.C7T	p.R3W	MFRNSLKMLLTGGKS	MFWNSLKMLLTGGKS	7.0	5.0	-	-	4235_17:61086927-61086927 C>T_MFWNSLKMLLTGGKS	0.0
8:144941537-144941537 T>C	1.0	4335	COLORECTAL	-	-	-	-	EPPK1	NM_031308,p.E1962G|uc003zaa.1,p.E1962G|ENST00000525985,p.E1962G	protein_coding	uc003zaa.1	nonsynonymous SNV	exon1	c.A5885G	p.E1962G	SVDEAVDVGLVNEELRERLLKAERA	SVDEAVDVGLVNGELRERLLKAERA	10.0	1.0	-	-	4335_8:144941537-144941537 T>C_SVDEAVDVGLVNGELRERLLKAERA	0.0
X:32663098-32663098 G>T	1.0	4317	COLORECTAL	-	-	-	-	DMD	uc004ddb.1,p.Q370K|NM_000109,p.Q370K|NM_004009,p.Q374K|ENST00000288447,p.Q370K|uc004dcz.2,p.Q255K|NM_004006,p.Q378K|NM_004010,p.Q255K|ENST00000378677,p.Q374K|uc004dda.1,p.Q378K|uc004ddf.3,p.Q370K|uc004dcy.1,p.Q374K|ENST00000357033,p.Q378K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ddf.3	nonsynonymous SNV	exon10	c.C1108A	p.Q370K	GEISNDVEVVKDQFHTHEGYMMDLT	GEISNDVEVVKDKFHTHEGYMMDLT	6.0	5.0	-	-	4317_X:32663098-32663098 G>T_GEISNDVEVVKDKFHTHEGYMMDLT	0.0
19:4652413-4652413 G>A	1.0	4259	COLORECTAL	-	-	-	-	TNFAIP8L1	uc021une.1,p.G178S|ENST00000536716,p.G178S|NM_001167942,p.G178S|uc021unf.1,p.G178S|uc002max.3,p.G178S|ENST00000327473,p.G178S|NM_152362,p.G178S	protein_coding, processed_transcript	uc021unf.1	nonsynonymous SNV	exon1	c.G532A	p.G178S	YRSHLRRICEGLGRMLDEGSL	YRSHLRRICEGLSRMLDEGSL	7.0	8.0	-	-	4259_19:4652413-4652413 G>A_YRSHLRRICEGLSRMLDEGSL	0.0
5:180486744-180486744 C>T	0.0	4316	COLORECTAL	-	-	-	-	BTNL9	uc003mmt.3,p.P497L|NM_152547,p.P497L|ENST00000376842,p.P498L|ENST00000327705,p.P497L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003mmt.3	nonsynonymous SNV	exon11	c.C1490T	p.P497L	YFRPRAHDGGEHPDPLTICPLPVRG	YFRPRAHDGGEHLDPLTICPLPVRG	6.0	1.0	-	-	4316_5:180486744-180486744 C>T_YFRPRAHDGGEHLDPLTICPLPVRG	0.0
X:23397816-23397816 G>C	0.0	4186	BREAST	-	-	-	-	PTCHD1	uc004dal.4,p.V154L|ENST00000379361,p.V154L|uc010nfu.2,p.V154L|NM_173495,p.V154L	protein_coding	uc010nfu.2	nonsynonymous SNV	exon2	c.G460C	p.V154L	LNNDKTCIVDDIVHVLEELKNARAT	LNNDKTCIVDDILHVLEELKNARAT	1.0	9.0	-	-	4186_X:23397816-23397816 G>C_LNNDKTCIVDDILHVLEELKNARAT	0.0
1:169439258-169439258 G>A	1.0	2369	MELANOMA	-	-	-	-	SLC19A2	NM_006996,p.P325L|ENST00000367804,p.P124L|ENST00000236137,p.P325L|uc001ggf.4,p.P124L|uc001gge.4,p.P325L|ENST00000367802,p.P287L	protein_coding	uc001ggf.4	nonsynonymous SNV	exon2	c.C371T	p.P124L	VNYTQGLWEKVMPSRYAAIYNGGVE	VNYTQGLWEKVMLSRYAAIYNGGVE	9.0	7.0	-	-	2369_1:169439258-169439258 G>A_VNYTQGLWEKVMLSRYAAIYNGGVE	0.0
8:114326907-114326907 T>G	0.0	4213	COLORECTAL	-	-	-	2	CSMD3	ENST00000455883,p.E98D|uc003ynt.3,p.E58D|NM_198124,p.E58D|uc003ynu.3,p.E98D|NM_052900,p.E98D|ENST00000343508,p.E58D|uc010mcx.1,p.E98D|uc011lhx.2,p.E98D|uc003ynx.4,p.E98D|ENST00000297405,p.E98D|NM_198123,p.E98D|ENST00000352409,p.E98D	retained_intron, protein_coding, processed_transcript	uc011lhx.2	nonsynonymous SNV	exon2	c.A294C	p.E98D	PNGANCTWVIIAEERNRIQIVFQSF	PNGANCTWVIIADERNRIQIVFQSF	2.0	7.0	-	-	4213_8:114326907-114326907 T>G_PNGANCTWVIIADERNRIQIVFQSF	0.0
20:49191091-49191091 A>T	1.0	4037	NSCLC	-	-	-	-	PTPN1	NM_002827,p.K131I|ENST00000371621,p.K131I|NM_001278618,p.K58I|ENST00000541713,p.K58I|uc002xvl.3,p.K131I|uc010zys.2,p.K58I	protein_coding	uc010zys.2	nonsynonymous SNV	exon4	c.A173T	p.K58I	LKCAQYWPQKEEKEMIFEDTNLKLT	LKCAQYWPQKEEIEMIFEDTNLKLT	9.0	10.0	-	-	4037_20:49191091-49191091 A>T_LKCAQYWPQKEEIEMIFEDTNLKLT	0.0
5:140537209-140537209 G>A	0.0	4240	BREAST	-	-	-	-	PCDHB17	uc003lis.3,p.E544K|ENST00000539533,p.E545K	protein_coding	uc003lis.3	nonsynonymous SNV	exon1	c.G1630A	p.E544K	GASDRGSPALSSEALVRVLVCWTPT	GASDRGSPALSSKALVRVLVCWTPT	5.0	7.0	-	-	4240_5:140537209-140537209 G>A_GASDRGSPALSSKALVRVLVCWTPT	0.0
11:68773372-68773372 C>A	0.0	4298	COLORECTAL	-	-	-	-	MRGPRF	uc001ooo.4,p.A136S|NM_001098515,p.A136S|ENST00000309099,p.A136S|uc001oop.4,p.A136S|NM_145015,p.A136S|ENST00000441623,p.A136S	protein_coding	uc001oop.4	nonsynonymous SNV	exon3	c.G406T	p.A136S	LCMFLTGVSLLPAVSAERCASVIFP	LCMFLTGVSLLPSVSAERCASVIFP	3.0	5.0	-	-	4298_11:68773372-68773372 C>A_LCMFLTGVSLLPSVSAERCASVIFP	0.0
X:31893388-31893388 G>A	0.0	3713	MELANOMA	-	-	-	-	DMD	NM_004011,p.H998Y|ENST00000378677,p.H2335Y|NM_004012,p.H995Y|uc004dda.1,p.H2339Y|NM_004010,p.H2216Y|NM_004009,p.H2335Y|NM_004006,p.H2339Y|NM_000109,p.H2331Y|uc004dcw.2,p.H995Y|uc004dcx.2,p.H998Y|ENST00000357033,p.H2339Y|ENST00000358062,p.H35Y|uc004dcy.1,p.H2335Y|uc004ddb.1,p.H2331Y|uc004dcz.2,p.H2216Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ddb.1	nonsynonymous SNV	exon48	c.C6991T	p.H2331Y	EKKLEDLEEQLNHLLLWLSPIRNQL	EKKLEDLEEQLNYLLLWLSPIRNQL	8.0	10.0	-	-	3713_X:31893388-31893388 G>A_EKKLEDLEEQLNYLLLWLSPIRNQL	0.0
6:32180934-32180934 G>A	0.0	4245	COLORECTAL	-	-	-	-	NOTCH4	ENST00000375023,p.L806F|uc003obb.3,p.L806F|NM_004557,p.L806F	retained_intron, protein_coding, processed_transcript	uc003obb.3	nonsynonymous SNV	exon15	c.C2416T	p.L806F	AMGFQGPRCEGKLRPSCADSPCRNR	AMGFQGPRCEGKFRPSCADSPCRNR	8.0	4.0	-	-	4245_6:32180934-32180934 G>A_AMGFQGPRCEGKFRPSCADSPCRNR	0.0
6:158551462-158551462 T>G	1.0	4237	NSCLC	-	-	-	-	SERAC1	NM_032861,p.E265D|ENST00000367104,p.E265D|uc003qrc.2,p.E265D|ENST00000367101,p.E265D|ENST00000367102,p.E265D	protein_coding	uc003qrc.2	nonsynonymous SNV	exon9	c.A795C	p.E265D	GGNGLPYAESFGEVPSATVEMFCLE	GGNGLPYAESFGDVPSATVEMFCLE	6.0	3.0	-	-	4237_6:158551462-158551462 T>G_GGNGLPYAESFGDVPSATVEMFCLE	0.0
1:44085794-44085794 G>A	1.0	3713	MELANOMA	-	-	-	-	PTPRF	ENST00000372407,p.G786R|NM_002840,p.G1714R|ENST00000438120,p.G1705R|uc001cju.3,p.G1103R|NM_130440,p.G1705R|uc009vwt.3,p.G1274R|ENST00000359947,p.G1714R|uc001cjs.3,p.G1705R|ENST00000372413,p.G1705R|uc001cjw.3,p.G940R|uc001cjr.3,p.G1714R|ENST00000372414,p.G1714R|uc001cjv.3,p.G1185R|ENST00000422171,p.G1073R	protein_coding, processed_transcript	uc009vwt.3	nonsynonymous SNV	exon21	c.G3820A	p.G1274R	GYRQQKAYIATQGPLAESTEDFWRM	GYRQQKAYIATQRPLAESTEDFWRM	8.0	6.0	-	-	3713_1:44085794-44085794 G>A_GYRQQKAYIATQRPLAESTEDFWRM	0.0
1:171509789-171509789 C>T	1.0	3713	MELANOMA	-	-	-	-	PRRC2C	NM_015172,p.P1060S|ENST00000392078,p.P1062S|ENST00000367742,p.P1062S|ENST00000338920,p.P1060S|uc010pmg.2,p.P1060S|uc010pmh.2,p.P37S|ENST00000426496,p.P1060S	retained_intron, protein_coding, processed_transcript	uc010pmh.2	nonsynonymous SNV	exon1	c.C109T	p.P37S	VKPEKTEKKDLPPPPPPPQPPAPIQ	VKPEKTEKKDLPSPPPPPQPPAPIQ	9.0	9.0	-	-	3713_1:171509789-171509789 C>T_VKPEKTEKKDLPSPPPPPQPPAPIQ	0.0
15:78882677-78882677 A>T	1.0	3716	MELANOMA	-	-	-	-	CHRNA5	NM_000745,p.E315V|ENST00000299565,p.E315V|uc002bdy.3,p.E315V	protein_coding	uc002bdy.3	nonsynonymous SNV	exon5	c.A944T	p.E315V	IPSSSKVIPLIGEYLVFTMIFVTLS	IPSSSKVIPLIGVYLVFTMIFVTLS	4.0	5.0	-	-	3716_15:78882677-78882677 A>T_IPSSSKVIPLIGVYLVFTMIFVTLS	0.0
7:138601857-138601857 T>G	0.0	4186	BREAST	-	-	-	2	KIAA1549	ENST00000422774,p.I839L|uc011kql.2,p.I839L|NM_001164665,p.I839L|NM_020910,p.I839L|ENST00000440172,p.I839L|ENST00000242365,p.I789L|uc011kqj.2,p.I839L	protein_coding	uc011kql.2	nonsynonymous SNV	exon2	c.A2515C	p.I839L	SFSKAIPTGTVLITDAYLPSGSSFV	SFSKAIPTGTVLLTDAYLPSGSSFV	3.0	6.0	-	-	4186_7:138601857-138601857 T>G_SFSKAIPTGTVLLTDAYLPSGSSFV	0.0
17:39023182-39023182 C>T	0.0	4301	MELANOMA	-	-	-	-	KRT12	uc002hvk.2,p.G86E|ENST00000251643,p.G86E|NM_000223,p.G86E	protein_coding	uc002hvk.2	nonsynonymous SNV	exon1	c.G257A	p.G86E	GSSMAGGLGAGYGRALGGGSFGGLG	GSSMAGGLGAGYERALGGGSFGGLG	1.0	5.0	-	-	4301_17:39023182-39023182 C>T_GSSMAGGLGAGYERALGGGSFGGLG	0.0
19:17769033-17769033 C>T	0.0	4287	COLORECTAL	-	-	-	-	UNC13A	NM_001080421,p.R202H|ENST00000551649,p.R202H|ENST00000252773,p.R202H|uc031rjv.1,p.R202H|ENST00000519716,p.R202H|ENST00000550896,p.R202H|ENST00000428389,p.R290H|ENST00000552293,p.R202H|uc031rjw.1,p.R202H	retained_intron, protein_coding	uc031rjw.1	nonsynonymous SNV	exon9	c.G605A	p.R202H	PDSAVDDRDSDYRSETSNSIPPPYY	PDSAVDDRDSDYHSETSNSIPPPYY	3.0	10.0	-	-	4287_19:17769033-17769033 C>T_PDSAVDDRDSDYHSETSNSIPPPYY	0.0
7:141170371-141170371 G>T	1.0	4287	COLORECTAL	-	-	-	-	TMEM178B	ENST00000565468,p.A224S|NM_001195278,p.A224S|uc003vwg.2,p.A224S	retained_intron, protein_coding	uc003vwg.2	nonsynonymous SNV	exon4	c.G670T	p.A224S	GTFCIISLCTCVAGINFELSRYPRY	GTFCIISLCTCVSGINFELSRYPRY	4.0	10.0	-	-	4287_7:141170371-141170371 G>T_GTFCIISLCTCVSGINFELSRYPRY	0.0
12:129563111-129563111 C>A	0.0	4326	BREAST	-	-	-	-	TMEM132D	uc009zyl.1,p.V695L|ENST00000422113,p.V695L|uc001uia.2,p.V233L|ENST00000389441,p.V233L|NM_133448,p.V695L	protein_coding	uc009zyl.1	nonsynonymous SNV	exon8	c.G2083T	p.V695L	SPGSNRAIFATAVAQELLQRPKQEA	SPGSNRAIFATALAQELLQRPKQEA	1.0	10.0	-	-	4326_12:129563111-129563111 C>A_SPGSNRAIFATALAQELLQRPKQEA	0.0
7:2987357-2987357 C>A	0.0	4110	BILE DUCT	-	-	-	1	CARD11	uc003smv.3,p.E24D|NM_032415,p.E24D|ENST00000356408,p.E24D|ENST00000396946,p.E24D	retained_intron, protein_coding	uc003smv.3	nonsynonymous SNV	exon3	c.G72T	p.E24D	METLKDEEDALWENVECNRHMLSRY	METLKDEEDALWDNVECNRHMLSRY	4.0	8.0	-	-	4110_7:2987357-2987357 C>A_METLKDEEDALWDNVECNRHMLSRY	0.0
2:233243689-233243689 G>A	0.0	2591	MELANOMA	-	-	-	-	ALPP	NM_001632,p.E29K|uc002vsq.3,p.E29K|ENST00000392027,p.E29K	retained_intron, protein_coding	uc002vsq.3	nonsynonymous SNV	exon2	c.G85A	p.E29K	LQLSLGIIPVEEENPDFWNREAAEA	LQLSLGIIPVEEKNPDFWNREAAEA	1.0	9.0	-	-	2591_2:233243689-233243689 G>A_LQLSLGIIPVEEKNPDFWNREAAEA	0.0
2:220471444-220471444 C>T	1.0	2556	MELANOMA	-	-	-	-	STK11IP	NM_052902,p.S344F|ENST00000456909,p.S333F|uc002vml.3,p.S344F|ENST00000295641,p.S344F|uc010zll.2,p.S301F|uc002vmm.1,p.S333F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zll.2	nonsynonymous SNV	exon11	c.C902T	p.S301F	KVLSLTDFQTHTSLGLSPMGPPLPW	KVLSLTDFQTHTFLGLSPMGPPLPW	7.0	7.0	-	-	2556_2:220471444-220471444 C>T_KVLSLTDFQTHTFLGLSPMGPPLPW	0.0
1:183556030-183556030 T>G	0.0	4246	COLORECTAL	-	-	-	-	NCF2	uc001gqk.4,p.K86T|NM_001127651,p.K86T|NM_001190794,p.K86T|uc010pod.2,p.K86T|NM_001190789,p.K86T|ENST00000418089,p.K86T|uc010poe.2,p.K86T|ENST00000413720,p.K86T|uc001gqj.4,p.K86T|NM_000433,p.K86T|ENST00000367535,p.K86T|ENST00000367536,p.K86T	protein_coding, processed_transcript	uc010poe.2	nonsynonymous SNV	exon2	c.A257C	p.K86T	YFQRGMLYYQTEKYDLAIKDLKEAL	YFQRGMLYYQTETYDLAIKDLKEAL	7.0	2.0	-	-	4246_1:183556030-183556030 T>G_YFQRGMLYYQTETYDLAIKDLKEAL	0.0
6:146480583-146480583 A>T	0.0	3919	MELANOMA	-	-	-	-	GRM1	ENST00000361719,p.E267V|uc003qll.3,p.E267V|NM_001278065,p.E267V|uc011edz.2,p.E267V|ENST00000492807,p.E267V|ENST00000355289,p.E267V|ENST00000282753,p.E267V|uc010khv.2,p.E267V|uc010khw.2,p.E267V|uc011eea.2,p.E267V|uc010khu.1,p.E267V|NM_001278066,p.E267V|ENST00000392299,p.E267V|ENST00000507907,p.E267V|NM_001278064,p.E267V|NM_001278067,p.E267V	retained_intron, protein_coding	uc011eea.2	nonsynonymous SNV	exon2	c.A800T	p.E267V	IAHSDKIYSNAGEKSFDRLLRKLRE	IAHSDKIYSNAGVKSFDRLLRKLRE	1.0	7.0	-	-	3919_6:146480583-146480583 A>T_IAHSDKIYSNAGVKSFDRLLRKLRE	0.0
11:4976077-4976077 T>G	0.0	4281	COLORECTAL	-	rs2570573	-	-	OR51A2	uc010qyt.2,p.K289N|ENST00000380371,p.K289N|NM_001004748,p.K289N	protein_coding	uc010qyt.2	nonsynonymous SNV	exon1	c.A867C	p.K289N	MANVLLLVPPLMKPIVYCVKTKQIR	MANVLLLVPPLMNPIVYCVKTKQIR	1.0	4.0	-	-	4281_11:4976077-4976077 T>G_MANVLLLVPPLMNPIVYCVKTKQIR	0.0
13:111277546-111277546 T>G	1.0	4071	COLORECTAL	-	-	-	-	CARKD	ENST00000309957,p.L103V|uc010tjj.2,p.L85V|NM_018210,p.L103V|uc001vrc.3,p.L103V|NM_001242881,p.L103V|uc001vrb.3,p.L103V|NM_001242882,p.L85V	protein_coding, processed_transcript	uc010tjj.2	nonsynonymous SNV	exon4	c.T253G	p.L85V	FAAISALKVGADLSHVFCASAAAPV	FAAISALKVGADVSHVFCASAAAPV	7.0	3.0	-	-	4071_13:111277546-111277546 T>G_FAAISALKVGADVSHVFCASAAAPV	0.0
2:180008467-180008467 C>A	1.0	4046	OVARIAN	-	-	-	-	SESTD1	ENST00000426988,p.W41L|NM_178123,p.W234L|ENST00000428443,p.W234L|uc002uni.4,p.W234L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uni.4	nonsynonymous SNV	exon9	c.G701T	p.W234L	QRRFNGSDGGVSWSPMDDELLAQPQ	QRRFNGSDGGVSLSPMDDELLAQPQ	7.0	8.0	-	-	4046_2:180008467-180008467 C>A_QRRFNGSDGGVSLSPMDDELLAQPQ	0.0
1:36564855-36564855 G>A	0.0	4298	COLORECTAL	-	-	-	-	COL8A2	NM_001294347,p.R78W|NM_005202,p.R143W|ENST00000303143,p.R143W|ENST00000397799,p.R143W|uc001bzv.2,p.R143W|uc001bzw.2,p.R78W|ENST00000481785,p.R78W	protein_coding	uc001bzw.2	nonsynonymous SNV	exon2	c.C232T	p.R78W	PGKVGPPGQPGLRGEPGIRGDQGLR	PGKVGPPGQPGLWGEPGIRGDQGLR	4.0	8.0	-	-	4298_1:36564855-36564855 G>A_PGKVGPPGQPGLWGEPGIRGDQGLR	0.0
19:36278357-36278357 C>A	1.0	4317	COLORECTAL	-	-	-	-	ARHGAP33	NM_001172630,p.P828T|ENST00000007510,p.P964T|uc002obs.2,p.P803T|ENST00000314737,p.P803T|uc002obt.2,p.P828T|ENST00000378944,p.P828T|uc002obv.1,p.P552T|NM_052948,p.P803T	retained_intron, protein_coding, processed_transcript	uc002obv.1	nonsynonymous SNV	exon8	c.C1654A	p.P552T	PPNSLAHPGAWVPGPPPYLPRQQSD	PPNSLAHPGAWVTGPPPYLPRQQSD	9.0	8.0	-	-	4317_19:36278357-36278357 C>A_PPNSLAHPGAWVTGPPPYLPRQQSD	0.0
X:73960054-73960054 C>G	0.0	4213	COLORECTAL	-	-	-	-	KIAA2022	ENST00000373468,p.K1446N|NM_001008537,p.K1446N|uc004eby.3,p.K1446N|ENST00000055682,p.K1446N	protein_coding	uc004eby.3	nonsynonymous SNV	exon3	c.G4338C	p.K1446N	MSTLGNNGPTHKKLYRHKSSSKALR	MSTLGNNGPTHKNLYRHKSSSKALR	3.0	5.0	-	-	4213_X:73960054-73960054 C>G_MSTLGNNGPTHKNLYRHKSSSKALR	0.0
5:176024465-176024465 G>C	1.0	3466	MELANOMA	-	-	-	-	GPRIN1	uc021yif.1,p.R791G|ENST00000303991,p.R791G|NM_052899,p.R791G|uc003meo.1,p.R791G	protein_coding	uc021yif.1	nonsynonymous SNV	exon1	c.C2371G	p.R791G	PEAAAPPPGPRTRDNFTKAPSWEAS	PEAAAPPPGPRTGDNFTKAPSWEAS	4.0	9.0	-	-	3466_5:176024465-176024465 G>C_PEAAAPPPGPRTGDNFTKAPSWEAS	0.0
17:62290230-62290230 C>T	0.0	4126	NSCLC	-	-	-	-	TEX2	ENST00000583097,p.A450T|ENST00000584379,p.A450T|NM_018469,p.A450T|NM_001288733,p.A450T|NM_001288732,p.A450T|uc002jec.3,p.A450T|uc002jed.3,p.A450T|ENST00000258991,p.A450T|uc002jee.3,p.A450T	retained_intron, protein_coding, processed_transcript	uc002jee.3	nonsynonymous SNV	exon2	c.G1348A	p.A450T	KLSDIPLKPEVLAEDGVVLDSEDEV	KLSDIPLKPEVLTEDGVVLDSEDEV	7.0	6.0	-	-	4126_17:62290230-62290230 C>T_KLSDIPLKPEVLTEDGVVLDSEDEV	0.0
11:35211573-35211573 C>T	1.0	3879	MELANOMA	-	-	-	-	CD44	NM_000610,p.P210S|uc001mvv.3,p.P210S|ENST00000525688,p.P49S|ENST00000434472,p.P210S|NM_001202557,p.P210S|uc001mvu.3,p.P210S|ENST00000531110,p.P84S|ENST00000428726,p.P210S|ENST00000449691,p.P210S|ENST00000263398,p.P210S|NM_001001391,p.P210S|uc021qfw.1,p.P210S|ENST00000433354,p.P210S|ENST00000360158,p.P210S|ENST00000415148,p.P210S|uc001mwc.4,p.P210S|ENST00000433892,p.P210S|uc010rer.2,p.P210S|NM_001001389,p.P210S|NM_001202555,p.P210S|NM_001202556,p.P210S|ENST00000352818,p.P210S|uc001mvx.3,p.P210S|uc001mvw.3,p.P210S|ENST00000533222,p.P43S|ENST00000437706,p.P210S|NM_001001390,p.P210S|ENST00000278385,p.P46S|ENST00000525211,p.P189S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qfw.1	nonsynonymous SNV	exon5	c.C628T	p.P210S	FSTVHPIPDEDSPWITDSTDRIPAT	FSTVHPIPDEDSSWITDSTDRIPAT	10.0	9.0	-	-	3879_11:35211573-35211573 C>T_FSTVHPIPDEDSSWITDSTDRIPAT	0.0
13:60686294-60686294 A>C	1.0	3713	MELANOMA	-	-	-	-	DIAPH3	ENST00000400330,p.I80M|ENST00000400324,p.I80M|uc001vht.4,p.I80M|NM_001042517,p.I80M|ENST00000267215,p.I80M|uc031qlw.1,p.I80M|NM_001258369,p.I80M	protein_coding, processed_transcript	uc031qlw.1	nonsynonymous SNV	exon3	c.T240G	p.I80M	TDDMLDKFASIRIPGSKKERPPLPN	TDDMLDKFASIRMPGSKKERPPLPN	2.0	4.0	-	-	3713_13:60686294-60686294 A>C_TDDMLDKFASIRMPGSKKERPPLPN	0.0
4:4861982-4861982 C>T	0.0	4240	BREAST	-	-	-	-	MSX1	ENST00000382723,p.S119L|uc003gif.3,p.S119L|NM_002448,p.S119L	protein_coding	uc003gif.3	nonsynonymous SNV	exon1	c.C356T	p.S119L	DAPSSPRPLGHFSVGGLLKLPEDAL	DAPSSPRPLGHFLVGGLLKLPEDAL	6.0	8.0	-	-	4240_4:4861982-4861982 C>T_DAPSSPRPLGHFLVGGLLKLPEDAL	0.0
17:33331306-33331306 C>G	1.0	4240	BREAST	-	-	-	-	LIG3	uc002hik.2,p.I937M|NM_013975,p.I937M|ENST00000378526,p.I937M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hik.2	nonsynonymous SNV	exon20	c.C2811G	p.I937M	DETLCQTKVLLDIFTGVRLYLPPST	DETLCQTKVLLDMFTGVRLYLPPST	9.0	8.0	-	-	4240_17:33331306-33331306 C>G_DETLCQTKVLLDMFTGVRLYLPPST	0.0
1:204970369-204970369 C>T	0.0	4266	COLORECTAL	-	-	-	-	NFASC	NM_001005388,p.H1031Y|ENST00000367170,p.H1059Y|ENST00000367172,p.H1138Y|ENST00000367171,p.H1123Y|ENST00000339876,p.H1031Y|ENST00000401399,p.H1031Y|uc001hbj.3,p.H1031Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001hbj.3	nonsynonymous SNV	exon26	c.C3091T	p.H1031Y	LPNSKWANITWKHNFGPGTDFVVEY	LPNSKWANITWKYNFGPGTDFVVEY	6.0	7.0	-	-	4266_1:204970369-204970369 C>T_LPNSKWANITWKYNFGPGTDFVVEY	0.0
11:85375534-85375534 G>A	0.0	3466	MELANOMA	-	-	-	-	CREBZF	ENST00000525639,p.P129L|ENST00000527447,p.P129L|ENST00000490820,p.P129L|ENST00000398294,p.P47L|uc001pas.2,p.P129L|ENST00000260058,p.P55L|NM_001039618,p.P129L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001pas.2	nonsynonymous SNV	exon1	c.C386T	p.P129L	DWHLDPGLSSPGPLSSSGGGSDSGG	DWHLDPGLSSPGLLSSSGGGSDSGG	10.0	2.0	-	-	3466_11:85375534-85375534 G>A_DWHLDPGLSSPGLLSSSGGGSDSGG	0.0
1:47016746-47016746 C>T	0.0	4046	OVARIAN	-	-	-	-	KNCN	NM_001097611,p.A48T|ENST00000396314,p.A48T|uc009vyh.1,p.A48T	retained_intron, protein_coding, processed_transcript	uc009vyh.1	nonsynonymous SNV	exon1	c.G142A	p.A48T	AAAAMGGVFIGAAVLGSLRIHPHPG	AAAAMGGVFIGATVLGSLRIHPHPG	3.0	5.0	-	-	4046_1:47016746-47016746 C>T_AAAAMGGVFIGATVLGSLRIHPHPG	0.0
14:70633747-70633747 A>T	0.0	4284	COLORECTAL	-	-	-	-	SLC8A3	ENST00000356921,p.S465T|uc001xlz.3,p.S465T|uc001xly.3,p.S465T|ENST00000494208,p.S465T|ENST00000381269,p.S465T|ENST00000528359,p.S465T|uc001xlw.3,p.S465T|NM_183002,p.S465T|uc001xlx.3,p.S465T|NM_182932,p.S465T|NM_058240,p.S465T|ENST00000534137,p.S465T|NM_033262,p.S465T|ENST00000357887,p.S465T	protein_coding, processed_transcript, nonsense_mediated_decay	uc001xlz.3	nonsynonymous SNV	exon2	c.T1393A	p.S465T	VVLKPGETQKEFSVGIIDDDIFEED	VVLKPGETQKEFTVGIIDDDIFEED	4.0	4.0	-	-	4284_14:70633747-70633747 A>T_VVLKPGETQKEFTVGIIDDDIFEED	0.0
17:2577445-2577445 G>T	1.0	4126	NSCLC	-	-	-	-	PAFAH1B1	ENST00000574468,p.D87Y|ENST00000397195,p.D255Y|NM_000430,p.D255Y|ENST00000451360,p.D84Y|uc010vqz.2,p.D84Y|uc002fuw.4,p.D255Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vqz.2	nonsynonymous SNV	exon3	c.G250T	p.D84Y	NQDGTLIASCSNDQTVRVWVVATKE	NQDGTLIASCSNYQTVRVWVVATKE	10.0	4.0	-	-	4126_17:2577445-2577445 G>T_NQDGTLIASCSNYQTVRVWVVATKE	0.0
6:136687151-136687151 G>A	0.0	4155	MELANOMA	0.0009	-	-	-	MAP7	NM_001198608,p.P354L|uc011edh.2,p.P317L|uc010kgq.2,p.P238L|NM_001198619,p.P186L|NM_001198611,p.P317L|ENST00000432797,p.P186L|ENST00000454590,p.P354L|uc010kgu.3,p.P354L|uc003qgz.3,p.P332L|uc010kgr.2,p.P186L|uc011edf.2,p.P317L|uc010kgv.3,p.P354L|NM_003980,p.P332L|uc011edi.2,p.P186L|ENST00000354570,p.P332L|NM_001198618,p.P186L|uc011edg.2,p.P362L|NM_001198615,p.P317L|NM_001198617,p.P238L|NM_001198609,p.P362L|ENST00000438100,p.P317L|ENST00000544465,p.P317L|uc010kgs.3,p.P186L|NM_001198614,p.P354L|uc003qha.2,p.P295L|NM_001198616,p.P295L	protein_coding	uc011edi.2	nonsynonymous SNV	exon10	c.C557T	p.P186L	KARQPARSRLWLPSKSLPHLPGTPR	KARQPARSRLWLLSKSLPHLPGTPR	3.0	5.0	-	-	4155_6:136687151-136687151 G>A_KARQPARSRLWLLSKSLPHLPGTPR	0.0
12:29911653-29911653 A>T	0.0	4110	BILE DUCT	-	-	-	-	TMTC1	NM_001193451,p.F180I|ENST00000539277,p.F180I|ENST00000551659,p.F180I|uc001rjc.1,p.F72I|ENST00000381224,p.F72I|ENST00000256062,p.F72I|NM_175861,p.F72I|ENST00000552618,p.F180I|uc001rjb.3,p.F72I|uc021qwi.1,p.F180I	retained_intron, protein_coding, processed_transcript	uc021qwi.1	nonsynonymous SNV	exon3	c.T538A	p.F180I	ADVLACLLFLLAFLSYNRSLDQGCV	ADVLACLLFLLAILSYNRSLDQGCV	4.0	9.0	-	-	4110_12:29911653-29911653 A>T_ADVLACLLFLLAILSYNRSLDQGCV	0.0
7:100636291-100636291 C>A	1.0	4287	COLORECTAL	-	-	-	-	MUC12	uc003uxo.3,p.T816K|ENST00000379442,p.T959K|NM_001164462,p.T816K|ENST00000536621,p.T816K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uxo.3	nonsynonymous SNV	exon2	c.C2447A	p.T816K	SMETTALPGSTTTPGLSERSTTFHS	SMETTALPGSTTKPGLSERSTTFHS	9.0	10.0	-	-	4287_7:100636291-100636291 C>A_SMETTALPGSTTKPGLSERSTTFHS	0.0
6:52993392-52993392 A>C	1.0	4252	COLORECTAL	-	-	-	-	GCM1	ENST00000259803,p.L308R|NM_003643,p.L308R|uc003pbp.3,p.L308R	protein_coding	uc003pbp.3	nonsynonymous SNV	exon6	c.T923G	p.L308R	AWSKNAALGRNHLADNCYSNYPFPL	AWSKNAALGRNHRADNCYSNYPFPL	4.0	3.0	-	-	4252_6:52993392-52993392 A>C_AWSKNAALGRNHRADNCYSNYPFPL	0.0
7:138968739-138968739 C>T	1.0	4000	MELANOMA	-	-	ID=COSM3735766,COSM3735767;OCCURENCE=1(skin)	-	UBN2	ENST00000288561,p.P947S|ENST00000473989,p.P1030S|NM_173569,p.P1030S|uc011kqr.2,p.P1030S	protein_coding	uc011kqr.2	nonsynonymous SNV	exon15	c.C3088T	p.P1030S	MVSQISTQGFKSPFSMAASPKLAAS	MVSQISTQGFKSSFSMAASPKLAAS	8.0	2.0	-	-	4000_7:138968739-138968739 C>T_MVSQISTQGFKSSFSMAASPKLAAS	0.0
3:113098349-113098349 T>A	1.0	4160	COLORECTAL	-	-	-	-	CFAP44	uc003eae.2,p.K701I|uc003ead.2,p.K701I|ENST00000295868,p.K701I|ENST00000393845,p.K701I|NM_001164496,p.K701I|NM_018338,p.K701I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eae.2	nonsynonymous SNV	exon17	c.A2102T	p.K701I	IEKRERQRELKEKIREERRNKLAAE	IEKRERQRELKEIIREERRNKLAAE	6.0	7.0	-	-	4160_3:113098349-113098349 T>A_IEKRERQRELKEIIREERRNKLAAE	0.0
9:140611572-140611572 C>T	1.0	3713	MELANOMA	-	-	-	-	EHMT1	uc004coa.3,p.P194S|ENST00000334856,p.P163S|uc004cob.1,p.P163S|ENST00000462484,p.P194S|NM_024757,p.P194S|NM_001145527,p.P194S|ENST00000460843,p.P194S|uc011mfc.2,p.P194S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011mfc.2	nonsynonymous SNV	exon3	c.C580T	p.P194S	GSADTEDRKLPAPGADVKVHRARKT	GSADTEDRKLPASGADVKVHRARKT	8.0	4.0	-	-	3713_9:140611572-140611572 C>T_GSADTEDRKLPASGADVKVHRARKT	0.0
12:49227067-49227067 T>C	1.0	4180	BREAST	-	-	-	-	DDX23	NM_004818,p.Y599C|ENST00000308025,p.Y599C|uc001rsm.3,p.Y599C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rsm.3	nonsynonymous SNV	exon13	c.A1796G	p.Y599C	KMLANFESGKHKYRQTVMFTATMPP	KMLANFESGKHKCRQTVMFTATMPP	10.0	8.0	-	-	4180_12:49227067-49227067 T>C_KMLANFESGKHKCRQTVMFTATMPP	0.0
10:94679770-94679770 C>T	1.0	3903	MELANOMA	-	-	-	-	EXOC6	uc001kig.3,p.S284F|ENST00000371552,p.S279F|uc001kie.3,p.S279F|uc009xub.3,p.S284F|ENST00000260762,p.S284F|NM_019053,p.S284F|uc010qnr.2,p.S300F|NM_001013848,p.S279F|ENST00000371547,p.S300F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010qnr.2	nonsynonymous SNV	exon9	c.C899T	p.S300F	EEILTVQDLVDFSPVYRCLHIYSVL	EEILTVQDLVDFFPVYRCLHIYSVL	8.0	7.0	-	-	3903_10:94679770-94679770 C>T_EEILTVQDLVDFFPVYRCLHIYSVL	0.0
13:36686031-36686031 C>T	0.0	4287	COLORECTAL	-	-	ID=COSM1366636,COSM1366635;OCCURENCE=1(large_intestine)	-	DCLK1	uc001uvf.3,p.R233H|NM_004734,p.R233H|ENST00000255448,p.R233H|ENST00000360631,p.R233H|ENST00000379892,p.R233H	protein_coding, processed_transcript	uc001uvf.3	nonsynonymous SNV	exon3	c.G698A	p.R233H	TDAIKLDSGVVKRLYTLDGKQVMCL	TDAIKLDSGVVKHLYTLDGKQVMCL	4.0	8.0	-	-	4287_13:36686031-36686031 C>T_TDAIKLDSGVVKHLYTLDGKQVMCL	0.0
6:148835494-148835494 C>T	0.0	4245	COLORECTAL	-	-	-	-	SASH1	uc003qme.1,p.S255L|NM_015278,p.S255L|ENST00000367467,p.S255L	protein_coding, processed_transcript	uc003qme.1	nonsynonymous SNV	exon9	c.C764T	p.S255L	NSREQSDDETEESVKFKRLHKLVNS	NSREQSDDETEELVKFKRLHKLVNS	6.0	8.0	-	-	4245_6:148835494-148835494 C>T_NSREQSDDETEELVKFKRLHKLVNS	0.0
19:1440056-1440056 G>A	1.0	4158	COLORECTAL	-	-	-	-	RPS15	uc002lsp.1,p.R43Q|ENST00000586686,p.R43Q|ENST00000593052,p.R50Q|NM_001018,p.R43Q|ENST00000586096,p.R43Q|ENST00000589656,p.R43Q|ENST00000233609,p.R16Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002lsp.1	nonsynonymous SNV	exon3	c.G128A	p.R43Q	EQLMQLYSARQRRRLNRGLRRKQHS	EQLMQLYSARQRQRLNRGLRRKQHS	10.0	4.0	CD8	-	4158_19:1440056-1440056 G>A_EQLMQLYSARQRQRLNRGLRRKQHS	2.0
12:49443499-49443499 C>T	1.0	4252	COLORECTAL	-	-	-	1	KMT2D	uc001rta.4,p.R1291Q|NM_003482,p.R1291Q|ENST00000301067,p.R1291Q	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon11	c.G3872A	p.R1291Q	ISGGKAEGEKGRRRSSPARSRIKQG	ISGGKAEGEKGRQRSSPARSRIKQG	8.0	9.0	-	-	4252_12:49443499-49443499 C>T_ISGGKAEGEKGRQRSSPARSRIKQG	0.0
2:136872909-136872909 C>T	1.0	4346	COLORECTAL	-	-	-	1	CXCR4	uc002tuy.3,p.V201I|uc010fnk.3,p.V182I|ENST00000409817,p.V201I|ENST00000241393,p.V197I|uc002tuz.3,p.V197I|NM_003467,p.V197I|NM_001008540,p.V201I	protein_coding, processed_transcript	uc010fnk.3	nonsynonymous SNV	exon2	c.G544A	p.V182I	ICDRFYPNDLWVVVFQFQHIMVGLI	ICDRFYPNDLWVIVFQFQHIMVGLI	8.0	8.0	-	-	4346_2:136872909-136872909 C>T_ICDRFYPNDLWVIVFQFQHIMVGLI	0.0
8:124154517-124154517 T>G	0.0	4320	COLORECTAL	-	-	ID=COSM1454622;OCCURENCE=1(large_intestine)	-	TBC1D31	uc011lih.2,p.L776V|ENST00000518805,p.L440V|ENST00000522420,p.L781V|ENST00000287380,p.L886V|uc003ypp.2,p.L886V|ENST00000521676,p.L763V|uc003yps.2,p.L520V|NM_145647,p.L886V	retained_intron, protein_coding, nonsense_mediated_decay	uc011lih.2	nonsynonymous SNV	exon18	c.T2326G	p.L776V	QSQKTQKVIKENLAKAEQACLNTDW	QSQKTQKVIKENVAKAEQACLNTDW	6.0	1.0	-	-	4320_8:124154517-124154517 T>G_QSQKTQKVIKENVAKAEQACLNTDW	0.0
3:65342775-65342775 C>T	1.0	4329	COLORECTAL	-	-	-	-	MAGI1	uc003dmn.3,p.G1223S|ENST00000402939,p.G1223S|NM_001033057,p.G1223S	retained_intron, protein_coding, processed_transcript	uc003dmn.3	nonsynonymous SNV	exon23	c.G3667A	p.G1223S	YDPSSDRHGPATGPQGVPEVRAGPD	YDPSSDRHGPATSPQGVPEVRAGPD	10.0	7.0	-	-	4329_3:65342775-65342775 C>T_YDPSSDRHGPATSPQGVPEVRAGPD	0.0
6:109978032-109978032 C>T	1.0	3903	MELANOMA	-	-	-	-	AK9	uc003ptn.2,p.R229K|NM_001145128,p.R229K|ENST00000532976,p.R229K|ENST00000368948,p.R229K|ENST00000424296,p.R229K|NM_145025,p.R229K|ENST00000285397,p.R229K|ENST00000448084,p.R152K|uc003ptr.4,p.R229K	retained_intron, protein_coding	uc003ptr.4	nonsynonymous SNV	exon8	c.G686A	p.R229K	QMVAEILHHLVQRPEDYLENVENIV	QMVAEILHHLVQKPEDYLENVENIV	4.0	10.0	-	-	3903_6:109978032-109978032 C>T_QMVAEILHHLVQKPEDYLENVENIV	0.0
13:33680924-33680924 T>G	0.0	4078	GASTRIC	-	-	-	-	STARD13	NM_052851,p.R947S|uc001uuv.3,p.R947S|ENST00000255486,p.R1057S|uc001uuw.3,p.R1065S|NM_178006,p.R1065S|NM_178007,p.R1057S|uc001uuu.3,p.R1057S|ENST00000336934,p.R1065S|NM_001243476,p.R1030S|uc001uux.3,p.R1030S|ENST00000399365,p.R947S	protein_coding, processed_transcript	uc001uux.3	nonsynonymous SNV	exon17	c.A3090C	p.R1030S	QYLIEPCGSGKSRLTHICRIDLKGH	QYLIEPCGSGKSSLTHICRIDLKGH	7.0	6.0	-	-	4078_13:33680924-33680924 T>G_QYLIEPCGSGKSSLTHICRIDLKGH	0.0
6:108831428-108831428 G>A	0.0	4335	COLORECTAL	-	-	-	-	LACE1	ENST00000368977,p.S359N|uc003psj.3,p.S359N|NM_145315,p.S359N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003psj.3	nonsynonymous SNV	exon11	c.G1076A	p.S359N	TFEELCERPLGASDYLELSKNFDTI	TFEELCERPLGANDYLELSKNFDTI	6.0	8.0	-	-	4335_6:108831428-108831428 G>A_TFEELCERPLGANDYLELSKNFDTI	0.0
20:61512461-61512461 G>C	0.0	4240	BREAST	-	-	-	-	DIDO1	uc002ydr.2,p.S1616C|uc002yds.2,p.S1616C|ENST00000395343,p.S1616C|NM_033081,p.S1616C|NM_001193369,p.S1616C|ENST00000266070,p.S1616C	protein_coding	uc002yds.2	nonsynonymous SNV	exon16	c.C4847G	p.S1616C	APMPVPEEKEPASSPWASGEKPPAG	APMPVPEEKEPACSPWASGEKPPAG	10.0	4.0	-	-	4240_20:61512461-61512461 G>C_APMPVPEEKEPACSPWASGEKPPAG	0.0
8:139165045-139165045 G>T	0.0	4213	COLORECTAL	-	-	ID=COSM317311,COSM317310;OCCURENCE=1(lung)	2	FAM135B	uc003yux.3,p.S459Y|ENST00000395297,p.S558Y|NM_015912,p.S558Y|uc003yvb.3,p.S120Y|uc003yuy.3,p.S558Y|uc003yva.3,p.S120Y|ENST00000276737,p.S558Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003yvb.3	nonsynonymous SNV	exon1	c.C359A	p.S120Y	GQAPVLTYIDVKSSNKNPSRAEPLV	GQAPVLTYIDVKYSNKNPSRAEPLV	2.0	4.0	-	-	4213_8:139165045-139165045 G>T_GQAPVLTYIDVKYSNKNPSRAEPLV	0.0
X:71932757-71932757 G>A	1.0	3903	MELANOMA	-	-	-	-	PHKA1	uc004eax.4,p.P34L|ENST00000541944,p.P34L|uc011mqi.2,p.P34L|ENST00000373542,p.P34L|NM_001172436,p.P34L|ENST00000339490,p.P34L|uc004eay.4,p.P34L|ENST00000373545,p.P34L|NM_002637,p.P34L|ENST00000373539,p.P34L|NM_001122670,p.P34L	protein_coding	uc011mqi.2	nonsynonymous SNV	exon2	c.C101T	p.P34L	ILCHQNPVTGLLPASYDQKDAWVRD	ILCHQNPVTGLLLASYDQKDAWVRD	5.0	10.0	CD8	-	3903_X:71932757-71932757 G>A_ILCHQNPVTGLLLASYDQKDAWVRD	1.0
19:12826110-12826110 A>G	1.0	3466	MELANOMA	-	-	-	-	TNPO2	NM_001136195,p.F199L|ENST00000588216,p.F199L|ENST00000441499,p.F199L|NM_001136196,p.F199L|ENST00000585886,p.F199L|ENST00000356861,p.F199L|uc002muq.3,p.F199L|uc002muo.3,p.F199L|NM_013433,p.F199L|uc002mup.3,p.F291L|ENST00000592287,p.F199L|uc002mur.3,p.F199L|ENST00000450764,p.F199L|ENST00000425528,p.F199L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc002mur.3	nonsynonymous SNV	exon8	c.T595C	p.F199L	KIRSHAIACVNQFIMDRAQALMDNI	KIRSHAIACVNQLIMDRAQALMDNI	9.0	8.0	-	-	3466_19:12826110-12826110 A>G_KIRSHAIACVNQLIMDRAQALMDNI	0.0
1:40098352-40098352 G>C	1.0	4189	MELANOMA	-	-	-	-	HEYL	ENST00000372852,p.S39W	protein_coding	ENST00000372852	nonsynonymous SNV	exon2	c.C116G	p.S39W	SQMARPLSTPSSSQMQARKKHRGII	SQMARPLSTPSSWQMQARKKHRGII	5.0	8.0	-	-	4189_1:40098352-40098352 G>C_SQMARPLSTPSSWQMQARKKHRGII	0.0
11:57004439-57004439 C>A	0.0	4077	BILE DUCT	-	-	-	-	APLNR	ENST00000257254,p.D14Y|ENST00000606794,p.D14Y|NM_005161,p.D14Y|uc001njo.3,p.D14Y	protein_coding	uc001njo.3	nonsynonymous SNV	exon1	c.G40T	p.D14Y	EEGGDFDNYYGADNQSECEYTDWKS	EEGGDFDNYYGAYNQSECEYTDWKS	4.0	9.0	-	-	4077_11:57004439-57004439 C>A_EEGGDFDNYYGAYNQSECEYTDWKS	0.0
2:56145148-56145148 C>T	1.0	3713	MELANOMA	-	-	-	-	EFEMP1	NM_001039349,p.G57S|ENST00000429909,p.G57S|ENST00000394555,p.G57S|ENST00000440439,p.G57S|NM_001039348,p.G57S|ENST00000394554,p.G57S|uc002rzi.3,p.G57S|ENST00000439193,p.G57S|uc002rzj.3,p.G57S|ENST00000438672,p.G57S|ENST00000355426,p.G57S	retained_intron, protein_coding, processed_transcript	uc002rzj.3	nonsynonymous SNV	exon4	c.G169A	p.G57S	IDECDIVPDACKGGMKCVNHYGGYL	IDECDIVPDACKSGMKCVNHYGGYL	6.0	5.0	-	-	3713_2:56145148-56145148 C>T_IDECDIVPDACKSGMKCVNHYGGYL	0.0
1:156669849-156669849 A>T	0.0	4335	COLORECTAL	-	-	-	-	CRABP2	ENST00000368221,p.V129D|uc021pbi.1,p.V129D|NM_001199723,p.V129D|uc001fpr.3,p.V129D|NM_001878,p.V129D|ENST00000368222,p.V129D	protein_coding	uc021pbi.1	nonsynonymous SNV	exon5	c.T386A	p.V129D	DGELILTMTADDVVCTRVYVRE	DGELILTMTADDDVCTRVYVRE	6.0	2.0	-	-	4335_1:156669849-156669849 A>T_DGELILTMTADDDVCTRVYVRE	0.0
16:11362878-11362878 C>T	0.0	4238	COLORECTAL	-	-	-	-	TNP2	uc002das.3,p.R81H|ENST00000312693,p.R81H|NM_005425,p.R81H	retained_intron, protein_coding	uc002das.3	nonsynonymous SNV	exon1	c.G242A	p.R81H	QSQSPNTSPPPKRHKKTMNSHHSPM	QSQSPNTSPPPKHHKKTMNSHHSPM	1.0	2.0	-	-	4238_16:11362878-11362878 C>T_QSQSPNTSPPPKHHKKTMNSHHSPM	0.0
10:38241783-38241783 G>A	1.0	3784	MELANOMA	-	-	-	-	ZNF25	uc001ize.1,p.P215S|uc001izf.1,p.P179S|ENST00000302609,p.P215S|NM_145011,p.P215S	protein_coding, processed_transcript	uc001izf.1	nonsynonymous SNV	exon7	c.C535T	p.P179S	ECNQCEKSFYQKPHLTEHQKTHTGE	ECNQCEKSFYQKSHLTEHQKTHTGE	6.0	4.0	-	-	3784_10:38241783-38241783 G>A_ECNQCEKSFYQKSHLTEHQKTHTGE	0.0
21:34399432-34399432 T>G	0.0	4158	COLORECTAL	-	-	-	1	OLIG2	uc002yqx.2,p.S88A|ENST00000333337,p.S88A|uc021wil.1,p.S88A|NM_005806,p.S88A|ENST00000382357,p.S88A	protein_coding	uc021wil.1	nonsynonymous SNV	exon1	c.T262G	p.S88A	KSSSSSTSSSTSSAAASSTKKDKKQ	KSSSSSTSSSTSAAAASSTKKDKKQ	2.0	4.0	-	-	4158_21:34399432-34399432 T>G_KSSSSSTSSSTSAAAASSTKKDKKQ	0.0
15:50782488-50782488 G>A	1.0	4158	COLORECTAL	-	-	-	1	USP8	uc010ufh.2,p.R561H|NM_001283049,p.R561H|NM_005154,p.R667H|ENST00000425032,p.R561H|uc001zyn.4,p.R667H|uc001zym.4,p.R667H|uc001zyl.4,p.R667H|ENST00000433963,p.R667H|ENST00000307179,p.R667H|NM_001128610,p.R667H|ENST00000396444,p.R667H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc010ufh.2	nonsynonymous SNV	exon11	c.G1682A	p.R561H	WAKFLDPITGTFRYYHSPTNTVHMY	WAKFLDPITGTFHYYHSPTNTVHMY	10.0	6.0	CD8	-	4158_15:50782488-50782488 G>A_WAKFLDPITGTFHYYHSPTNTVHMY	2.0
2:128750881-128750881 G>A	1.0	3795	MELANOMA	-	-	-	-	SAP130	ENST00000357702,p.P479S|uc002tpq.1,p.P452S|NM_024545,p.P479S|NM_001145928,p.P479S|ENST00000259235,p.P479S|uc002tpp.2,p.P479S|ENST00000259234,p.P453S|uc010fmd.2,p.P479S|uc002tpn.2,p.P240S	protein_coding	uc010fmd.2	nonsynonymous SNV	exon12	c.C1435T	p.P479S	NPVAMETRSDNRPSVPVQFQYFLPT	NPVAMETRSDNRSSVPVQFQYFLPT	7.0	4.0	-	-	3795_2:128750881-128750881 G>A_NPVAMETRSDNRSSVPVQFQYFLPT	0.0
20:30584991-30584991 G>A	0.0	2359	MELANOMA	-	-	-	-	XKR7	ENST00000217299,p.E491K|NM_001011718,p.E491K|uc002wxe.3,p.E491K	protein_coding	uc002wxe.3	nonsynonymous SNV	exon3	c.G1471A	p.E491K	TTGAERDGASAGERAGTPTPPVFQV	TTGAERDGASAGKRAGTPTPPVFQV	1.0	5.0	-	-	2359_20:30584991-30584991 G>A_TTGAERDGASAGKRAGTPTPPVFQV	0.0
16:1392991-1392991 C>G	1.0	4281	COLORECTAL	-	-	-	-	BAIAP3	NM_001199099,p.N385K|ENST00000568887,p.N385K|uc002clk.2,p.N448K|ENST00000397489,p.N430K|NM_001199097,p.N413K|NM_003933,p.N448K|uc002clj.3,p.N430K|ENST00000562208,p.N390K|ENST00000421665,p.N377K|uc010uva.2,p.N385K|NM_001199098,p.N390K|uc021tag.1,p.N390K|ENST00000397488,p.N430K|NM_001199096,p.N377K|ENST00000324385,p.N448K|NM_001286464,p.N430K|uc010uvc.1,p.N377K|ENST00000426824,p.N413K|uc010uuz.2,p.N413K	retained_intron, protein_coding, processed_transcript	uc021tag.1	nonsynonymous SNV	exon14	c.C1170G	p.N390K	AATILCLHGAQSNLSPLQLAVLHWQ	AATILCLHGAQSKLSPLQLAVLHWQ	7.0	7.0	-	-	4281_16:1392991-1392991 C>G_AATILCLHGAQSKLSPLQLAVLHWQ	0.0
14:78392237-78392237 T>C	1.0	3879	MELANOMA	-	-	-	-	ADCK1	ENST00000341211,p.M312T|uc001xuj.3,p.M312T|NM_020421,p.M380T|NM_001142545,p.M312T|uc001xul.3,p.M87T|ENST00000238561,p.M380T|uc001xui.3,p.M380T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001xul.3	nonsynonymous SNV	exon2	c.T260C	p.M87T	LGAGDLYPLFACMLTARSWDSVNRG	LGAGDLYPLFACTLTARSWDSVNRG	5.0	5.0	-	-	3879_14:78392237-78392237 T>C_LGAGDLYPLFACTLTARSWDSVNRG	0.0
20:44581151-44581151 C>A	0.0	4186	BREAST	-	-	-	-	ZNF335	uc002xqw.3,p.D942Y|ENST00000426788,p.D787Y|uc010zxk.2,p.D787Y|ENST00000322927,p.D942Y|NM_022095,p.D942Y|uc002xqv.3,p.D54Y	protein_coding, processed_transcript	uc010zxk.2	nonsynonymous SNV	exon17	c.G2359T	p.D787Y	DGTQLHHIELTADGSISFPSPDALA	DGTQLHHIELTAYGSISFPSPDALA	5.0	6.0	-	-	4186_20:44581151-44581151 C>A_DGTQLHHIELTAYGSISFPSPDALA	0.0
8:72156896-72156896 C>T	0.0	4326	BREAST	0.0005	-	ID=COSM1458102;OCCURENCE=1(large_intestine)	-	EYA1	ENST00000340726,p.R361Q|uc003xyu.3,p.R361Q|NM_172058,p.R361Q|uc011lfe.2,p.R355Q|uc003xyv.3,p.R239Q|NM_001288575,p.R239Q|NM_001288574,p.R355Q|ENST00000388743,p.R360Q|uc010lzf.3,p.R288Q|ENST00000388740,p.R328Q|ENST00000303824,p.R355Q|ENST00000388741,p.R327Q|uc003xyt.4,p.R328Q|NM_172060,p.R328Q|NM_000503,p.R361Q|uc003xys.4,p.R361Q|ENST00000388742,p.R361Q	retained_intron, protein_coding, nonsense_mediated_decay	uc011lfe.2	nonsynonymous SNV	exon12	c.G1064A	p.R355Q	GRDPPTSVSLGLRMEEMIFNLADTH	GRDPPTSVSLGLQMEEMIFNLADTH	3.0	9.0	-	-	4326_8:72156896-72156896 C>T_GRDPPTSVSLGLQMEEMIFNLADTH	0.0
6:33424102-33424102 C>T	1.0	3784	MELANOMA	-	-	-	-	ZBTB9	ENST00000395064,p.R409W|NM_152735,p.R409W|uc021ywp.1,p.R409W|uc003oeq.3,p.R409W	protein_coding, processed_transcript	uc021ywp.1	nonsynonymous SNV	exon1	c.C1225T	p.R409W	KRDRHIMLTFSLRPFGCGICNKRFK	KRDRHIMLTFSLWPFGCGICNKRFK	6.0	2.0	-	-	3784_6:33424102-33424102 C>T_KRDRHIMLTFSLWPFGCGICNKRFK	0.0
8:123966232-123966232 G>A	0.0	4345	COLORECTAL	-	-	-	-	ZHX2	uc003ypk.1,p.D828N|ENST00000314393,p.D828N|uc022bag.1,p.D828N|NM_014943,p.D828N	protein_coding	uc022bag.1	nonsynonymous SNV	exon1	c.G2482A	p.D828N	AEGVSELAESDSDCVPAEAGQA	AEGVSELAESDSNCVPAEAGQA	5.0	10.0	-	-	4345_8:123966232-123966232 G>A_AEGVSELAESDSNCVPAEAGQA	0.0
1:70715707-70715707 G>T	1.0	4245	COLORECTAL	-	-	-	-	SRSF11	uc001dev.3,p.L175F|ENST00000370949,p.L305F|ENST00000370950,p.L365F|uc001deu.2,p.L372F|NM_001190987,p.L365F|NM_004768,p.L365F|ENST00000405432,p.L365F|ENST00000395136,p.L372F|ENST00000370951,p.L365F|uc001det.3,p.L365F|uc001des.3,p.L365F	protein_coding, processed_transcript	uc001dev.3	nonsynonymous SNV	exon9	c.G525T	p.L175F	RSPKKPRSPKRKLSRSPSPRRHKKE	RSPKKPRSPKRKFSRSPSPRRHKKE	10.0	8.0	-	-	4245_1:70715707-70715707 G>T_RSPKKPRSPKRKFSRSPSPRRHKKE	0.0
6:45332945-45332945 T>A	1.0	4287	COLORECTAL	-	-	-	-	SUPT3H	NM_003599,p.S32C|ENST00000306867,p.S32C|uc003oxp.4,p.S32C|ENST00000371459,p.S32C|uc003oxn.2,p.S32C|ENST00000475057,p.S32C	protein_coding, processed_transcript, nonsense_mediated_decay	uc003oxp.4	nonsynonymous SNV	exon2	c.A94T	p.S32C	TGKSISFATELQSMMYSLGDARRPL	TGKSISFATELQCMMYSLGDARRPL	8.0	3.0	CD8	-	4287_6:45332945-45332945 T>A_TGKSISFATELQCMMYSLGDARRPL	1.0
3:100170756-100170756 G>A	0.0	4246	COLORECTAL	-	-	ID=COSM1035617;OCCURENCE=1(endometrium)	-	LNP1	uc003dtx.4,p.R117Q|ENST00000383693,p.R117Q|ENST00000489752,p.R130Q|NM_001085451,p.R117Q	protein_coding, nonsense_mediated_decay	uc003dtx.4	nonsynonymous SNV	exon3	c.G350A	p.R117Q	HSKIEKFSESFERQLCFRTKRSASL	HSKIEKFSESFEQQLCFRTKRSASL	5.0	5.0	-	-	4246_3:100170756-100170756 G>A_HSKIEKFSESFEQQLCFRTKRSASL	0.0
4:54930446-54930446 A>C	1.0	4335	COLORECTAL	-	-	-	2	CHIC2	uc003haj.2,p.Y8D|ENST00000512964,p.Y8D|NM_012110,p.Y8D|ENST00000263921,p.Y8D	retained_intron, protein_coding	uc003haj.2	nonsynonymous SNV	exon1	c.T22G	p.Y8D	MADFDEIYEEEEDEERALEE	MADFDEIDEEEEDEERALEE	7.0	6.0	-	-	4335_4:54930446-54930446 A>C_MADFDEIDEEEEDEERALEE	0.0
21:43239986-43239986 G>A	1.0	4320	COLORECTAL	-	-	-	-	PRDM15	uc002yzr.1,p.R795C|ENST00000433067,p.R1104C|ENST00000447207,p.R738C|ENST00000398548,p.R775C|NM_001282934,p.R795C|ENST00000422911,p.R795C|uc002yzq.1,p.R1104C|NM_001040424,p.R775C|uc002yzo.3,p.R775C|ENST00000538201,p.R758C|ENST00000269844,p.R1104C|uc002yzp.3,p.R795C|ENST00000447016,p.R738C|NM_022115,p.R1104C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002yzr.1	nonsynonymous SNV	exon19	c.C2383T	p.R795C	SFARKDMLKEHMRVHDNVREYLCAE	SFARKDMLKEHMCVHDNVREYLCAE	7.0	10.0	-	-	4320_21:43239986-43239986 G>A_SFARKDMLKEHMCVHDNVREYLCAE	0.0
1:180910201-180910201 C>T	0.0	4326	BREAST	-	-	-	-	KIAA1614	ENST00000367587,p.T601I|uc001gom.1,p.T71I|NM_020950,p.T980I|uc001gok.2,p.T980I|uc001gol.1,p.T601I|ENST00000367588,p.T980I	protein_coding, processed_transcript	uc001gom.1	nonsynonymous SNV	exon3	c.C212T	p.T71I	GHVLSRASAGAGTGPGSPSAAPLDQ	GHVLSRASAGAGIGPGSPSAAPLDQ	3.0	5.0	-	-	4326_1:180910201-180910201 C>T_GHVLSRASAGAGIGPGSPSAAPLDQ	0.0
2:71839933-71839933 C>T	1.0	3713	MELANOMA	-	-	-	-	DYSF	uc010feo.3,p.P1476S|NM_001130983,p.P1445S|uc002sif.3,p.P1445S|ENST00000409651,p.P1476S|uc010fek.3,p.P1462S|uc010fee.3,p.P1444S|ENST00000410041,p.P1462S|NM_001130980,p.P1461S|uc002sig.4,p.P1430S|ENST00000409582,p.P1461S|ENST00000394120,p.P1445S|uc010fen.3,p.P1462S|NM_001130987,p.P1462S|NM_001130981,p.P1461S|NM_001130978,p.P1444S|uc002sie.3,p.P1444S|uc010yqz.2,p.P184S|uc010fej.3,p.P1431S|NM_001130977,p.P1430S|NM_001130984,p.P1431S|NM_001130455,p.P1445S|uc010feg.3,p.P1475S|ENST00000409744,p.P1431S|NM_001130986,p.P1431S|NM_001130979,p.P1475S|ENST00000409366,p.P1445S|ENST00000258104,p.P1444S|NM_003494,p.P1444S|ENST00000413539,p.P1475S|NM_001130985,p.P1462S|uc010fef.3,p.P1461S|ENST00000429174,p.P1444S|NM_001130982,p.P1476S|uc010yqy.2,p.P325S|uc010fel.3,p.P1431S|ENST00000409762,p.P1461S|uc010fem.3,p.P1445S|ENST00000410020,p.P1462S|NM_001130976,p.P1430S|uc010fei.3,p.P1461S|uc010feh.3,p.P1430S	protein_coding, processed_transcript	uc010yqz.2	nonsynonymous SNV	exon5	c.C550T	p.P184S	PYSAESPSPQGGPDDVSLLSPGEDV	PYSAESPSPQGGSDDVSLLSPGEDV	3.0	5.0	-	-	3713_2:71839933-71839933 C>T_PYSAESPSPQGGSDDVSLLSPGEDV	0.0
16:57918229-57918229 A>T	0.0	4287	COLORECTAL	-	-	-	-	CNGB1	NM_001286130,p.S1193T|ENST00000251102,p.S1199T|ENST00000564448,p.S1193T|uc010cdh.2,p.S1193T|uc002emt.2,p.S1199T|NM_001297,p.S1199T	retained_intron, protein_coding, processed_transcript	uc010cdh.2	nonsynonymous SNV	exon33	c.T3577A	p.S1193T	RTPPEPPGSPPSSPPPASLGRPEGE	RTPPEPPGSPPSTPPPASLGRPEGE	1.0	9.0	-	-	4287_16:57918229-57918229 A>T_RTPPEPPGSPPSTPPPASLGRPEGE	0.0
1:28864473-28864473 G>A	1.0	3903	MELANOMA	-	-	-	-	RCC1	ENST00000398958,p.G407E|NM_001048195,p.G424E|ENST00000373833,p.G407E|uc001bqa.2,p.G407E|uc001bqc.2,p.G407E|ENST00000373831,p.G438E|NM_001048194,p.G438E|NM_001048199,p.G407E|uc001bqg.2,p.G407E|NM_001269,p.G407E|ENST00000373832,p.G407E|uc001bqf.2,p.G438E|uc001bqb.2,p.G407E|uc001bqe.2,p.G424E	retained_intron, protein_coding, nonsense_mediated_decay	uc001bqg.2	nonsynonymous SNV	exon10	c.G1220A	p.G407E	QLENRVVLSVSSGGQHTVLLVKDKE	QLENRVVLSVSSEGQHTVLLVKDKE	9.0	4.0	-	-	3903_1:28864473-28864473 G>A_QLENRVVLSVSSEGQHTVLLVKDKE	0.0
17:21205537-21205537 T>C	1.0	4155	MELANOMA	-	-	-	-	MAP2K3	ENST00000342679,p.I161T|ENST00000316920,p.I132T|uc021tsr.1,p.I132T|ENST00000361818,p.I132T|uc002gys.3,p.I161T|NM_145109,p.I161T|uc002gyt.3,p.I132T|ENST00000526076,p.I132T|uc021tsq.1,p.I132T|NM_002756,p.I132T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tsr.1	nonsynonymous SNV	exon7	c.T395C	p.I132T	KFYRKVLDKNMTIPEDILGEIAVSI	KFYRKVLDKNMTTPEDILGEIAVSI	8.0	1.0	-	-	4155_17:21205537-21205537 T>C_KFYRKVLDKNMTTPEDILGEIAVSI	0.0
9:128206805-128206805 G>A	1.0	4244	COLORECTAL	-	-	-	-	MAPKAP1	ENST00000373511,p.A426V|ENST00000394063,p.A281V|ENST00000373503,p.A281V|ENST00000373498,p.A473V|uc011lzv.2,p.A181V|NM_001006620,p.A281V|uc004bpy.3,p.A437V|NM_001006617,p.A473V|NM_001006619,p.A426V|uc004bpz.3,p.A426V|uc011lzu.2,p.A281V|NM_001006621,p.A281V|NM_024117,p.A437V|ENST00000265960,p.A473V|ENST00000350766,p.A437V|ENST00000373497,p.A186V|uc004bpv.3,p.A473V|uc004bpw.3,p.A281V|uc004bpx.3,p.A281V|uc011lzt.2,p.A276V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lzv.2	nonsynonymous SNV	exon6	c.C542T	p.A181V	HDYKHLYFESDAATVNEIVLKVNYI	HDYKHLYFESDAVTVNEIVLKVNYI	10.0	1.0	-	-	4244_9:128206805-128206805 G>A_HDYKHLYFESDAVTVNEIVLKVNYI	0.0
9:96416825-96416825 T>C	1.0	3919	MELANOMA	-	-	-	-	PHF2	uc004aub.3,p.V307A|NM_005392,p.V307A|ENST00000359246,p.V307A|uc011lug.1,p.V190A	protein_coding	uc011lug.1	nonsynonymous SNV	exon7	c.T569C	p.V190A	FADQVDKCYKCIVKQGQTLFIPSGW	FADQVDKCYKCIAKQGQTLFIPSGW	5.0	4.0	-	-	3919_9:96416825-96416825 T>C_FADQVDKCYKCIAKQGQTLFIPSGW	0.0
9:84609198-84609198 G>T	0.0	4284	COLORECTAL	-	-	-	-	SPATA31D1	NM_001001670,p.E1271D|ENST00000344803,p.E1271D|uc004amn.3,p.E1271D	protein_coding	uc004amn.3	nonsynonymous SNV	exon4	c.G3813T	p.E1271D	LEDSGIRVAQKQEPRVPTCVLQKCQ	LEDSGIRVAQKQDPRVPTCVLQKCQ	4.0	9.0	-	-	4284_9:84609198-84609198 G>T_LEDSGIRVAQKQDPRVPTCVLQKCQ	0.0
4:87968330-87968330 G>A	1.0	3713	MELANOMA	-	-	-	1	AFF1	uc011ccy.2,p.V215I|uc011ccx.2,p.V149I|ENST00000503477,p.V215I|uc003hqk.4,p.V208I|uc003hqh.2,p.V215I|uc003hqj.4,p.V208I|ENST00000395146,p.V215I|NM_005935,p.V208I|ENST00000507468,p.V215I|ENST00000307808,p.V208I|uc011ccz.2,p.V215I|NM_001166693,p.V215I	retained_intron, protein_coding, processed_transcript	uc011ccz.2	nonsynonymous SNV	exon4	c.G643A	p.V215I	RELSPLISLPSPVPPLSPIHSNQQT	RELSPLISLPSPIPPLSPIHSNQQT	7.0	5.0	-	-	3713_4:87968330-87968330 G>A_RELSPLISLPSPIPPLSPIHSNQQT	0.0
9:125438336-125438336 C>G	0.0	3775	CERVICAL	-	-	-	-	OR1L3	uc011lzb.2,p.Q310E|ENST00000304820,p.Q310E|NM_001005234,p.Q310E	protein_coding	uc011lzb.2	nonsynonymous SNV	exon1	c.C928G	p.Q310E	RGLQKLINKIKSQMSRFSTKTNKIC	RGLQKLINKIKSEMSRFSTKTNKIC	1.0	5.0	-	-	3775_9:125438336-125438336 C>G_RGLQKLINKIKSEMSRFSTKTNKIC	0.0
19:15491154-15491154 C>T	1.0	3775	CERVICAL	-	-	-	-	AKAP8L	ENST00000397410,p.E574K|NM_014371,p.E574K|NM_001291478,p.E513K|uc002naw.1,p.E574K|ENST00000595465,p.E513K|uc010xoh.1,p.E513K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xoh.1	nonsynonymous SNV	exon14	c.G1537A	p.E513K	AEGGALDEGAQGEAAGISEGAEGVP	AEGGALDEGAQGKAAGISEGAEGVP	10.0	5.0	-	-	3775_19:15491154-15491154 C>T_AEGGALDEGAQGKAAGISEGAEGVP	0.0
10:1070582-1070582 C>T	0.0	4240	BREAST	-	-	-	-	IDI2	ENST00000277517,p.D28N|NM_033261,p.D28N|uc001ifv.1,p.D28N	protein_coding	uc001ifv.1	nonsynonymous SNV	exon2	c.G82A	p.D28N	RLEEMLIVVDENDKVIGADTKRNCH	RLEEMLIVVDENNKVIGADTKRNCH	3.0	8.0	-	-	4240_10:1070582-1070582 C>T_RLEEMLIVVDENNKVIGADTKRNCH	0.0
12:124281258-124281258 A>T	0.0	4298	COLORECTAL	-	-	-	-	DNAH10	uc010tav.1,p.K105M|uc010taw.1,p.K48M|ENST00000409039,p.K563M|uc001uft.4,p.K563M|NM_207437,p.K563M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010taw.1	nonsynonymous SNV	exon2	c.A143T	p.K48M	IFVQNLENPPLYKNHPPVAGAIYWE	IFVQNLENPPLYMNHPPVAGAIYWE	3.0	7.0	-	-	4298_12:124281258-124281258 A>T_IFVQNLENPPLYMNHPPVAGAIYWE	0.0
2:3605750-3605750 C>T	1.0	4180	BREAST	-	-	-	-	RNASEH1	NM_002936,p.G34D|ENST00000315212,p.G34D|uc002qxt.3,p.G34D	retained_intron, protein_coding, nonsense_mediated_decay	uc002qxt.3	nonsynonymous SNV	exon1	c.G101A	p.G34D	SRGFGMFYAVRRGRKTGVFLTWNEC	SRGFGMFYAVRRDRKTGVFLTWNEC	8.0	7.0	-	-	4180_2:3605750-3605750 C>T_SRGFGMFYAVRRDRKTGVFLTWNEC	0.0
13:109318335-109318335 C>T	0.0	4160	COLORECTAL	-	-	-	-	MYO16	uc010agk.2,p.R44C|NM_015011,p.R22C|ENST00000251041,p.R22C|NM_001198950,p.R44C|uc001vqt.1,p.R22C|ENST00000357550,p.R22C|ENST00000356711,p.R22C	protein_coding, processed_transcript	uc010agk.2	nonsynonymous SNV	exon2	c.C130T	p.R44C	SLPLGQRQRLVKRMRCEQIKAYYER	SLPLGQRQRLVKCMRCEQIKAYYER	2.0	10.0	-	-	4160_13:109318335-109318335 C>T_SLPLGQRQRLVKCMRCEQIKAYYER	0.0
7:1784468-1784468 C>T	1.0	4213	COLORECTAL	-	-	-	-	ELFN1	NM_001128636,p.S79L|ENST00000424383,p.S79L|uc031swk.1,p.S79L|uc010ksg.2,p.S79L|ENST00000561626,p.S79L|ENST00000541472,p.S79L	protein_coding	uc031swk.1	nonsynonymous SNV	exon1	c.C236T	p.S79L	LNENRIRSVQYASLSRFGNLTYLNL	LNENRIRSVQYALLSRFGNLTYLNL	5.0	9.0	-	-	4213_7:1784468-1784468 C>T_LNENRIRSVQYALLSRFGNLTYLNL	0.0
8:99441463-99441463 G>A	0.0	4213	COLORECTAL	-	-	ID=COSM1102909;OCCURENCE=1(endometrium)	-	KCNS2	uc022azb.1,p.R419H|ENST00000287042,p.R419H|ENST00000521839,p.R419H|uc003yin.3,p.R419H|NM_020697,p.R419H	protein_coding	uc022azb.1	nonsynonymous SNV	exon1	c.G1256A	p.R419H	TLIFNKFSHFYRRQKQLESAMRSCD	TLIFNKFSHFYRHQKQLESAMRSCD	3.0	9.0	-	-	4213_8:99441463-99441463 G>A_TLIFNKFSHFYRHQKQLESAMRSCD	0.0
10:72179672-72179672 A>C	1.0	4298	COLORECTAL	-	-	-	-	EIF4EBP2	NM_004096,p.T50P|ENST00000373218,p.T50P|uc001jrb.3,p.T50P	protein_coding	uc001jrb.3	nonsynonymous SNV	exon2	c.A148C	p.T50P	PGGTLFSTTPGGTRIIYDRKFLLDR	PGGTLFSTTPGGPRIIYDRKFLLDR	6.0	1.0	-	-	4298_10:72179672-72179672 A>C_PGGTLFSTTPGGPRIIYDRKFLLDR	0.0
20:62124571-62124571 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	EEF1A2	uc002yfe.2,p.A231S|ENST00000217182,p.A231S|ENST00000298049,p.A231S|NM_001958,p.A231S	protein_coding	uc002yfe.2	nonsynonymous SNV	exon5	c.G691T	p.A231S	KEGNASGVSLLEALDTILPPTRPTD	KEGNASGVSLLESLDTILPPTRPTD	7.0	8.0	-	-	4258_20:62124571-62124571 C>A_KEGNASGVSLLESLDTILPPTRPTD	0.0
9:123165097-123165097 T>C	0.0	4345	COLORECTAL	-	-	-	-	CDK5RAP2	uc011lxw.3,p.E1030G|ENST00000416449,p.E1159G|ENST00000349780,p.E1765G|uc010mvi.3,p.E774G|NM_001011649,p.E1686G|NM_018249,p.E1765G|uc004bkg.4,p.E1686G|NM_001272039,p.E1535G|ENST00000359309,p.E1724G|uc011lxz.3,p.E1030G|uc011lya.3,p.E1030G|ENST00000425647,p.E775G|uc004bkf.4,p.E1765G|uc004bkh.2,p.E1535G|ENST00000360822,p.E1733G|uc004bke.3,p.E1050G|ENST00000360190,p.E1686G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lya.3	nonsynonymous SNV	exon34	c.A3089G	p.E1030G	IQTQEAPSSTSQELGTKGPHPAPLS	IQTQEAPSSTSQGLGTKGPHPAPLS	9.0	2.0	-	-	4345_9:123165097-123165097 T>C_IQTQEAPSSTSQGLGTKGPHPAPLS	0.0
1:114483132-114483132 T>C	1.0	4301	MELANOMA	-	-	-	-	HIPK1	ENST00000514621,p.Y43H|ENST00000369561,p.Y43H|NM_198268,p.Y43H|ENST00000426820,p.Y43H|uc001een.3,p.Y43H|ENST00000369555,p.Y43H|NM_152696,p.Y43H|ENST00000369558,p.Y43H|uc001eem.3,p.Y43H|ENST00000369554,p.Y43H|ENST00000503968,p.Y43H|ENST00000369559,p.Y43H|uc001eel.3,p.Y43H	protein_coding	uc001een.3	nonsynonymous SNV	exon2	c.T127C	p.Y43H	WDVSGQSSNDKYYTHSKTLPATQGQ	WDVSGQSSNDKYHTHSKTLPATQGQ	8.0	8.0	-	-	4301_1:114483132-114483132 T>C_WDVSGQSSNDKYHTHSKTLPATQGQ	0.0
6:97247390-97247390 A>T	0.0	4259	COLORECTAL	-	-	-	-	GPR63	uc003pou.3,p.F73Y|ENST00000229955,p.F73Y|NM_001143957,p.F73Y|uc021zcy.1,p.F73Y|uc010kcl.3,p.F73Y|ENST00000417980,p.F73Y|NM_030784,p.F73Y	protein_coding	uc021zcy.1	nonsynonymous SNV	exon1	c.T218A	p.F73Y	VNSTAVPTTPAAFKSLNLPLQITLS	VNSTAVPTTPAAYKSLNLPLQITLS	3.0	2.0	-	-	4259_6:97247390-97247390 A>T_VNSTAVPTTPAAYKSLNLPLQITLS	0.0
17:65184513-65184513 G>A	1.0	3466	MELANOMA	-	-	-	-	HELZ	ENST00000580168,p.R362C|uc002jfx.4,p.R362C|NM_014877,p.R362C|ENST00000579953,p.R362C|uc010wqk.2,p.R362C|ENST00000417253,p.R362C|ENST00000358691,p.R362C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc010wqk.2	nonsynonymous SNV	exon12	c.C1084T	p.R362C	GIAFNTEIFGTFRQTIVFDFGLEPV	GIAFNTEIFGTFCQTIVFDFGLEPV	8.0	9.0	-	-	3466_17:65184513-65184513 G>A_GIAFNTEIFGTFCQTIVFDFGLEPV	0.0
5:140432164-140432164 C>A	0.0	4129	NSCLC	-	-	-	-	PCDHB1	NM_013340,p.T370N|ENST00000306549,p.T370N|uc003lik.1,p.T370N	protein_coding	uc003lik.1	nonsynonymous SNV	exon1	c.C1109A	p.T370N	EDSPPQTVVALFTIRDRDIRVGGKV	EDSPPQTVVALFNIRDRDIRVGGKV	1.0	4.0	-	-	4129_5:140432164-140432164 C>A_EDSPPQTVVALFNIRDRDIRVGGKV	0.0
17:60060290-60060290 C>A	1.0	4071	COLORECTAL	-	-	-	-	MED13	uc002izo.3,p.G1025V|ENST00000397786,p.G1025V|NM_005121,p.G1025V	retained_intron, protein_coding, processed_transcript	uc002izo.3	nonsynonymous SNV	exon16	c.G3074T	p.G1025V	RTPRTPRTPRGAGGPASAQGSVKYE	RTPRTPRTPRGAVGPASAQGSVKYE	9.0	4.0	-	-	4071_17:60060290-60060290 C>A_RTPRTPRTPRGAVGPASAQGSVKYE	0.0
21:34925262-34925262 C>T	1.0	4180	BREAST	-	-	-	-	SON	uc002ysg.3,p.S233L|ENST00000356577,p.S1242L|NM_001291411,p.S1242L|uc002ysb.1,p.S1242L|uc002yse.1,p.S1242L|NM_032195,p.S1242L|uc002ysd.3,p.S233L|ENST00000290239,p.S1242L|NM_138927,p.S1242L|ENST00000455528,p.S1242L|ENST00000381679,p.S1242L|uc021win.1,p.S888L|ENST00000300278,p.S1242L|uc002ysc.3,p.S1242L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021win.1	nonsynonymous SNV	exon1	c.C2663T	p.S888L	YSVSASDPSVLVSEAAVTVPEPPPE	YSVSASDPSVLVLEAAVTVPEPPPE	10.0	10.0	-	-	4180_21:34925262-34925262 C>T_YSVSASDPSVLVLEAAVTVPEPPPE	0.0
22:31658127-31658127 C>T	1.0	4180	BREAST	-	-	-	-	LIMK2	uc011aln.2,p.R104W|NM_001031801,p.R166W|ENST00000333611,p.R166W|NM_005569,p.R187W|NM_016733,p.R166W|uc003akk.3,p.R166W|ENST00000340552,p.R166W|uc003akj.3,p.R166W|uc003akh.3,p.R187W|ENST00000406516,p.R109W|ENST00000331728,p.R187W	retained_intron, protein_coding, processed_transcript	uc011aln.2	nonsynonymous SNV	exon5	c.C310T	p.R104W	NYATTVQVKEVNRMHISPNNRNAIH	NYATTVQVKEVNWMHISPNNRNAIH	8.0	8.0	-	-	4180_22:31658127-31658127 C>T_NYATTVQVKEVNWMHISPNNRNAIH	0.0
15:52416716-52416716 G>A	1.0	3784	MELANOMA	-	-	-	-	GNB5	uc031qrz.1,p.P84S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qrz.1	nonsynonymous SNV	exon3	c.C250T	p.P84S	DMKTALALYEFPPMGLLSALDHGII	DMKTALALYEFPSMGLLSALDHGII	5.0	6.0	-	-	3784_15:52416716-52416716 G>A_DMKTALALYEFPSMGLLSALDHGII	0.0
3:184025700-184025700 G>C	1.0	4078	GASTRIC	-	-	-	-	PSMD2	uc011brk.1,p.G644A|NM_001278709,p.G615A|ENST00000435761,p.G615A|ENST00000439383,p.G644A|uc003fnn.1,p.G774A|NM_001278708,p.G644A|ENST00000310118,p.G774A|NM_002808,p.G774A|uc011brj.1,p.G615A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011brk.1	nonsynonymous SNV	exon17	c.G1931C	p.G644A	VRLAQGLTHLGKGTLTLCPYHSDRQ	VRLAQGLTHLGKATLTLCPYHSDRQ	10.0	8.0	-	-	4078_3:184025700-184025700 G>C_VRLAQGLTHLGKATLTLCPYHSDRQ	0.0
6:35467907-35467907 C>T	1.0	4196	COLORECTAL	-	-	-	-	TULP1	NM_001289395,p.R396H|uc003okv.4,p.R449H|uc003okw.4,p.R396H|ENST00000322263,p.R396H|ENST00000229771,p.R449H|NM_003322,p.R449H	retained_intron, protein_coding	uc003okw.4	nonsynonymous SNV	exon13	c.G1187A	p.R396H	IRPRNASDGLLVRWQNKTLESLIEL	IRPRNASDGLLVHWQNKTLESLIEL	5.0	7.0	-	-	4196_6:35467907-35467907 C>T_IRPRNASDGLLVHWQNKTLESLIEL	0.0
20:62198871-62198871 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1615869;OCCURENCE=2(liver)	-	HELZ2	ENST00000467148,p.D614N|ENST00000427522,p.D45N|NM_033405,p.D45N|uc002yfl.1,p.D45N|NM_001037335,p.D614N|uc002yfm.2,p.D614N	retained_intron, protein_coding, processed_transcript	uc002yfm.2	nonsynonymous SNV	exon7	c.G1840A	p.D614N	RVMYTDRPLSQTDPVTLQYCCLTDD	RVMYTDRPLSQTNPVTLQYCCLTDD	8.0	7.0	CD8	-	3713_20:62198871-62198871 C>T_RVMYTDRPLSQTNPVTLQYCCLTDD	1.0
16:3433076-3433076 G>A	0.0	4238	COLORECTAL	-	-	-	-	ZSCAN32	NM_017810,p.R412W|uc002cux.4,p.R623W|NM_001284528,p.R335W|ENST00000304926,p.R412W|NM_001284529,p.R335W|NM_001284527,p.R624W|ENST00000439568,p.R335W|uc002cuy.4,p.R335W|uc002cuz.3,p.R412W|ENST00000396852,p.R624W|ENST00000396846,p.R624W|uc010uwx.2,p.R335W	retained_intron, protein_coding, nonsense_mediated_decay	uc010uwx.2	nonsynonymous SNV	exon3	c.C1003T	p.R335W	KRFNNSSQFSAHRRIHTGESPYKCA	KRFNNSSQFSAHWRIHTGESPYKCA	6.0	4.0	-	-	4238_16:3433076-3433076 G>A_KRFNNSSQFSAHWRIHTGESPYKCA	0.0
19:14161608-14161608 C>T	0.0	3795	MELANOMA	0.0005	-	-	-	IL27RA	NM_004843,p.P481S|ENST00000263379,p.P481S|uc002mxx.4,p.P481S	protein_coding	uc002mxx.4	nonsynonymous SNV	exon11	c.C1441T	p.P481S	SGNTQSVTLPDLPWGPCELWVTAST	SGNTQSVTLPDLSWGPCELWVTAST	6.0	6.0	-	-	3795_19:14161608-14161608 C>T_SGNTQSVTLPDLSWGPCELWVTAST	0.0
1:27632755-27632755 C>T	1.0	3713	MELANOMA	-	-	-	-	WDTC1	ENST00000361771,p.P638S|NM_001276252,p.P639S|ENST00000319394,p.P639S|NM_015023,p.P638S|uc009vst.3,p.P639S|uc001bno.4,p.P638S|ENST00000472249,p.P87S	protein_coding, processed_transcript, nonsense_mediated_decay	uc009vst.3	nonsynonymous SNV	exon16	c.C1915T	p.P639S	ASQANQRRMNADPLEVMLLNMGYRI	ASQANQRRMNADSLEVMLLNMGYRI	8.0	2.0	-	-	3713_1:27632755-27632755 C>T_ASQANQRRMNADSLEVMLLNMGYRI	0.0
2:135628543-135628543 G>C	1.0	4252	COLORECTAL	-	-	-	-	ACMSD	ENST00000392928,p.A139P|ENST00000356140,p.A197P|ENST00000283054,p.A139P|uc002ttz.3,p.A197P|NM_138326,p.A197P|uc002tua.3,p.A139P	retained_intron, protein_coding	uc002tua.3	nonsynonymous SNV	exon7	c.G415C	p.A139P	AKYWLPWLVGMPAETTIAICSMIMG	AKYWLPWLVGMPPETTIAICSMIMG	1.0	6.0	-	-	4252_2:135628543-135628543 G>C_AKYWLPWLVGMPPETTIAICSMIMG	0.0
7:120935621-120935621 C>T	1.0	3795	MELANOMA	0.0005	-	ID=COSM274319;OCCURENCE=1(large_intestine)	-	CPED1	ENST00000310396,p.S999L|NM_024913,p.S999L|uc003vjq.4,p.S999L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003vjq.4	nonsynonymous SNV	exon23	c.C2996T	p.S999L	SKLQQGTVTNFRSPYHVRGPINQVC	SKLQQGTVTNFRLPYHVRGPINQVC	7.0	4.0	-	-	3795_7:120935621-120935621 C>T_SKLQQGTVTNFRLPYHVRGPINQVC	0.0
4:178274759-178274759 A>G	1.0	3713	MELANOMA	-	-	-	-	NEIL3	uc003iut.2,p.K446R|NM_018248,p.K446R|ENST00000264596,p.K446R	protein_coding, nonsense_mediated_decay	uc003iut.2	nonsynonymous SNV	exon8	c.A1337G	p.K446R	KKTTNDITQPSSKVNISPTISSESK	KKTTNDITQPSSRVNISPTISSESK	2.0	4.0	-	-	3713_4:178274759-178274759 A>G_KKTTNDITQPSSRVNISPTISSESK	0.0
X:151909198-151909198 G>A	1.0	3713	MELANOMA	-	-	-	-	CSAG1	NM_153478,p.G76D|NM_001102576,p.G76D|ENST00000452779,p.G76D|ENST00000370287,p.G76D|uc004fgf.3,p.G76D|uc004fge.3,p.G76D	protein_coding, nonsense_mediated_decay	uc004fgf.3	nonsynonymous SNV	exon4	c.G227A	p.G76D	EKGPVKEVPGTKGSP	EKGPVKEVPGTKDSP	4.0	10.0	-	-	3713_X:151909198-151909198 G>A_EKGPVKEVPGTKDSP	0.0
4:185606598-185606598 C>T	1.0	3466	MELANOMA	-	-	-	-	PRIMPOL	ENST00000314970,p.P378S|NM_152683,p.P378S|ENST00000508001,p.P52S|ENST00000503752,p.P378S|ENST00000515774,p.P249S|uc003iwm.2,p.P249S|uc003iwk.2,p.P378S|NM_001300767,p.P249S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003iwm.2	nonsynonymous SNV	exon9	c.C745T	p.P249S	VETIEGFQCSPYPEVDHFVLSLVNK	VETIEGFQCSPYSEVDHFVLSLVNK	7.0	4.0	-	-	3466_4:185606598-185606598 C>T_VETIEGFQCSPYSEVDHFVLSLVNK	0.0
6:34386174-34386174 C>T	1.0	4240	BREAST	-	-	-	-	RPS10,RPS10-NUDT3	NM_001202470,p.G143E|ENST00000605528,p.G143E|uc021yyt.1,p.G143E	protein_coding, processed_transcript	uc021yyt.1	nonsynonymous SNV	exon5	c.G428A	p.G143E	AVPPGADKKAEAGAGSATEFQFVLL	AVPPGADKKAEAEAGSATEFQFVLL	10.0	6.0	CD8	-	4240_6:34386174-34386174 C>T_AVPPGADKKAEAEAGSATEFQFVLL	2.0
X:140993492-140993492 G>C	0.0	4258	ENDOMETRIAL	-	-	-	-	MAGEC1	uc004fbt.3,p.S101T|ENST00000285879,p.S101T|NM_005462,p.S101T	protein_coding	uc004fbt.3	nonsynonymous SNV	exon4	c.G302C	p.S101T	GDDTQSPLQNSQSSPEGKDSLSPLE	GDDTQSPLQNSQTSPEGKDSLSPLE	5.0	4.0	-	-	4258_X:140993492-140993492 G>C_GDDTQSPLQNSQTSPEGKDSLSPLE	0.0
6:35987386-35987388 CTC>-	0.0	4329	COLORECTAL	-	-	-	-	SLC26A8	NM_052961,p.33_33del|uc003oll.3,p.33_33del|ENST00000480663,p.119_119del|ENST00000355574,p.33_33del|NM_001193476,p.33_33del|NM_138718,p.33_33del|uc003olm.3,p.33_33del|ENST00000394602,p.33_33del|ENST00000490799,p.33_33del|uc003oln.3,p.33_33del	retained_intron, protein_coding, nonsense_mediated_decay	uc003oln.3	nonframeshift deletion	exon2	c.97_99del	p.33_33del	FAYDVKREVYNEETFQQEHKRKASS	FAYDVKREVYNETFQQEHKRKASSS	1.0	10.0	-	-	4329_6:35987386-35987388 CTC>-_FAYDVKREVYNETFQQEHKRKASSS	0.0
1:237969525-237969525 C>A	0.0	4129	NSCLC	-	-	-	-	RYR2	uc010pyb.1,p.A180D|ENST00000366574,p.A4747D|NM_001035,p.A4747D|ENST00000360064,p.A4753D|ENST00000542537,p.A4731D|uc001hyl.1,p.A4747D	protein_coding, processed_transcript	uc010pyb.1	nonsynonymous SNV	exon7	c.C539A	p.A180D	NNFFFAAHLLDIAMGFKTLRTILSS	NNFFFAAHLLDIDMGFKTLRTILSS	1.0	3.0	-	-	4129_1:237969525-237969525 C>A_NNFFFAAHLLDIDMGFKTLRTILSS	0.0
15:77907398-77907398 C>T	0.0	4316	COLORECTAL	0.0005	-	ID=COSM1563346;OCCURENCE=1(large_intestine)	-	LINGO1	NM_001301192,p.R278H|NM_001301199,p.R278H|uc002bcu.1,p.R278H|NM_001301189,p.R278H|NM_001301191,p.R278H|NM_001301187,p.R278H|NM_032808,p.R284H|NM_001301195,p.R278H|NM_001301194,p.R278H|ENST00000561030,p.R278H|NM_001301198,p.R278H|uc002bct.1,p.R284H|NM_001301197,p.R278H|ENST00000355300,p.R284H|NM_001301186,p.R278H|ENST00000557798,p.R289H|NM_001301200,p.R278H	protein_coding, processed_transcript	uc002bcu.1	nonsynonymous SNV	exon4	c.G833A	p.R278H	HCNLTAVPYLAVRHLVYLRFLNLSY	HCNLTAVPYLAVHHLVYLRFLNLSY	4.0	3.0	-	-	4316_15:77907398-77907398 C>T_HCNLTAVPYLAVHHLVYLRFLNLSY	0.0
3:108788569-108788569 G>A	0.0	3795	MELANOMA	-	-	-	-	MORC1	uc003dxl.3,p.S242F|ENST00000483760,p.S242F|NM_014429,p.S242F|uc011bhn.2,p.S242F|ENST00000232603,p.S242F	protein_coding	uc011bhn.2	nonsynonymous SNV	exon9	c.C725T	p.S242F	DFPARWSFRAYTSVLYFNPWMRIFI	DFPARWSFRAYTFVLYFNPWMRIFI	1.0	2.0	-	-	3795_3:108788569-108788569 G>A_DFPARWSFRAYTFVLYFNPWMRIFI	0.0
14:92909140-92909140 T>G	0.0	2556	MELANOMA	-	-	-	-	SLC24A4	ENST00000531433,p.C188G|uc010twm.2,p.C188G|uc001yak.3,p.C188G|NM_153647,p.C188G|uc001yai.3,p.C124G|NM_153648,p.C124G|ENST00000298877,p.C171G|ENST00000351924,p.C171G|NM_153646,p.C188G|ENST00000532405,p.C188G|uc010auj.3,p.C79G|ENST00000393265,p.C124G	retained_intron, protein_coding, processed_transcript	uc010twm.2	nonsynonymous SNV	exon7	c.T562G	p.C188G	SAVFNILCIIGVCGLFAGQVVRLTW	SAVFNILCIIGVGGLFAGQVVRLTW	4.0	6.0	-	-	2556_14:92909140-92909140 T>G_SAVFNILCIIGVGGLFAGQVVRLTW	0.0
1:162743262-162743262 C>T	0.0	4284	COLORECTAL	-	-	-	1	DDR2	NM_006182,p.H578Y|uc001gcg.3,p.H578Y|uc001gcf.3,p.H578Y|NM_001014796,p.H578Y|ENST00000367922,p.H578Y|ENST00000367921,p.H578Y	protein_coding	uc001gcg.3	nonsynonymous SNV	exon14	c.C1732T	p.H578Y	KEKLGEGQFGEVHLCEVEGMEKFKD	KEKLGEGQFGEVYLCEVEGMEKFKD	7.0	7.0	-	-	4284_1:162743262-162743262 C>T_KEKLGEGQFGEVYLCEVEGMEKFKD	0.0
11:20181837-20181837 C>T	1.0	4281	COLORECTAL	-	-	-	-	DBX1	ENST00000524983,p.G12R|NM_001029865,p.G12R|ENST00000227256,p.G12R|uc021qey.1,p.G12R	protein_coding	uc021qey.1	nonsynonymous SNV	exon1	c.G34A	p.G12R	MMFPGLLAPPAGYPSLLRPTPTLT	MMFPGLLAPPARYPSLLRPTPTLT	3.0	3.0	-	-	4281_11:20181837-20181837 C>T_MMFPGLLAPPARYPSLLRPTPTLT	0.0
19:18778920-18778920 C>T	1.0	4301	MELANOMA	-	-	-	-	KLHL26	NM_018316,p.P238L|uc002njz.1,p.P238L|ENST00000300976,p.P238L	protein_coding, processed_transcript, nonsense_mediated_decay	uc002njz.1	nonsynonymous SNV	exon3	c.C713T	p.P238L	LFRAAVRWLQHDPARRPRASHVLCH	LFRAAVRWLQHDLARRPRASHVLCH	6.0	7.0	-	-	4301_19:18778920-18778920 C>T_LFRAAVRWLQHDLARRPRASHVLCH	0.0
X:154182265-154182265 C>T	0.0	4155	MELANOMA	-	-	-	-	F8	ENST00000360256,p.R602Q|uc004fmt.3,p.R602Q|NM_000132,p.R602Q	protein_coding, processed_transcript	uc004fmt.3	nonsynonymous SNV	exon12	c.G1805A	p.R602Q	RNVILFSVFDENRSWYLTENIQRFL	RNVILFSVFDENQSWYLTENIQRFL	5.0	10.0	-	-	4155_X:154182265-154182265 C>T_RNVILFSVFDENQSWYLTENIQRFL	0.0
13:38237742-38237742 G>A	1.0	3713	MELANOMA	-	-	-	-	TRPC4	uc010abw.3,p.S327F|ENST00000379673,p.S500F|uc010abx.3,p.S500F|uc001uws.3,p.S500F|ENST00000379705,p.S500F|ENST00000379679,p.S327F|uc001uwt.3,p.S500F|ENST00000379681,p.S500F|NM_016179,p.S500F|NM_001135957,p.S500F|NM_001135955,p.S500F|ENST00000447043,p.S500F|ENST00000355779,p.S500F|uc010aby.3,p.S500F|uc010tey.2,p.S500F|NM_001135958,p.S327F|uc010abv.3,p.S80F|ENST00000338947,p.S327F|ENST00000358477,p.S500F|NM_001135956,p.S500F|NM_003306,p.S500F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010tey.2	nonsynonymous SNV	exon6	c.C1499T	p.S500F	SSLRLISLFTANSHLGPLQISLGRM	SSLRLISLFTANFHLGPLQISLGRM	1.0	10.0	-	-	3713_13:38237742-38237742 G>A_SSLRLISLFTANFHLGPLQISLGRM	0.0
11:58602195-58602195 C>T	0.0	3903	MELANOMA	-	-	-	-	GLYATL2	ENST00000532258,p.D198N|ENST00000287275,p.D198N|uc001nnd.4,p.D198N|uc009ymq.3,p.D198N|NM_145016,p.D198N	protein_coding, processed_transcript	uc009ymq.3	nonsynonymous SNV	exon7	c.G592A	p.D198N	ERSLKYIERCLQDFLGFGVLGPEGQ	ERSLKYIERCLQNFLGFGVLGPEGQ	1.0	4.0	-	-	3903_11:58602195-58602195 C>T_ERSLKYIERCLQNFLGFGVLGPEGQ	0.0
19:6415658-6415658 G>A	1.0	3466	MELANOMA	-	-	-	-	KHSRP	ENST00000398148,p.P592L|ENST00000594496,p.P13L|NM_003685,p.P592L|uc002mer.4,p.P592L	retained_intron, protein_coding	uc002mer.4	nonsynonymous SNV	exon17	c.C1775T	p.P592L	YSHYYQQPPGPVPGPAPAPAAPPAQ	YSHYYQQPPGPVLGPAPAPAAPPAQ	10.0	2.0	CD8	-	3466_19:6415658-6415658 G>A_YSHYYQQPPGPVLGPAPAPAAPPAQ	1.0
5:176951636-176951636 C>T	1.0	2369	MELANOMA	-	-	-	-	FAM193B	uc003mht.3,p.E242K|ENST00000514747,p.E616K|NM_001190946,p.E616K|ENST00000443375,p.E583K|uc003mhu.3,p.E616K|ENST00000329540,p.E242K|uc003mhr.3,p.E120K|uc003mhv.3,p.E242K|uc021yiw.1,p.E242K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021yiw.1	nonsynonymous SNV	exon3	c.G724A	p.E242K	PGYPSSEEPSSKEVPSCKQELPEPV	PGYPSSEEPSSKKVPSCKQELPEPV	7.0	4.0	-	-	2369_5:176951636-176951636 C>T_PGYPSSEEPSSKKVPSCKQELPEPV	0.0
20:43379423-43379423 G>A	0.0	4189	MELANOMA	-	-	-	-	KCNK15	NM_022358,p.G313R|uc002xmr.3,p.G313R|ENST00000372861,p.G313R	protein_coding	uc002xmr.3	nonsynonymous SNV	exon2	c.G937A	p.G313R	RDNLGFSPPSSPGVVRGGQAPRLGA	RDNLGFSPPSSPRVVRGGQAPRLGA	3.0	6.0	-	-	4189_20:43379423-43379423 G>A_RDNLGFSPPSSPRVVRGGQAPRLGA	0.0
11:5653734-5653734 T>C	0.0	4246	COLORECTAL	-	-	-	-	TRIM34,TRIM6-TRIM34	NM_021616,p.V58A|uc001mbf.3,p.V412A|uc001mbj.3,p.V58A|uc001mbh.3,p.V58A|ENST00000457787,p.V58A|NM_130390,p.V58A|ENST00000429814,p.V58A|ENST00000514226,p.V58A|NM_001003819,p.V412A|ENST00000354852,p.V412A|uc001mbi.3,p.V58A|NM_001003827,p.V58A	retained_intron, protein_coding, processed_transcript	uc001mbj.3	nonsynonymous SNV	exon1	c.T173C	p.V58A	AVTSMGGKSSCPVCGISYSFEHLQA	AVTSMGGKSSCPACGISYSFEHLQA	6.0	4.0	-	-	4246_11:5653734-5653734 T>C_AVTSMGGKSSCPACGISYSFEHLQA	0.0
19:42585066-42585066 G>A	1.0	4317	COLORECTAL	-	-	ID=COSM1481127;OCCURENCE=1(breast)	-	ZNF574	NM_022752,p.D770N|uc002osk.4,p.D860N|ENST00000222339,p.D860N|ENST00000359044,p.D770N|ENST00000600245,p.D770N|uc021uva.1,p.D770N|uc002osm.4,p.D770N	protein_coding	uc021uva.1	nonsynonymous SNV	exon1	c.G2308A	p.D770N	RIHTGERPYPCPDCGKAFRQSTHLK	RIHTGERPYPCPNCGKAFRQSTHLK	6.0	8.0	-	-	4317_19:42585066-42585066 G>A_RIHTGERPYPCPNCGKAFRQSTHLK	0.0
19:56934532-56934532 A>G	1.0	4317	COLORECTAL	-	-	-	-	ZNF583	uc010ygl.1,p.T169A|ENST00000333201,p.T169A|NM_001159861,p.T169A|ENST00000291598,p.T169A|uc010ygm.1,p.T169A|NM_152478,p.T169A|uc002qnc.2,p.T169A|NM_001159860,p.T169A	retained_intron, protein_coding, processed_transcript	uc010ygm.1	nonsynonymous SNV	exon5	c.A505G	p.T169A	EYNKSWQTFHQDTIFDIQQSFPTKE	EYNKSWQTFHQDAIFDIQQSFPTKE	5.0	6.0	-	-	4317_19:56934532-56934532 A>G_EYNKSWQTFHQDAIFDIQQSFPTKE	0.0
17:4904079-4904079 C>T	1.0	2591	MELANOMA	-	-	-	-	KIF1C	uc002gan.2,p.P40L|NM_006612,p.P40L|ENST00000320785,p.P40L|ENST00000574165,p.P40L	retained_intron, protein_coding, processed_transcript	uc002gan.2	nonsynonymous SNV	exon4	c.C119T	p.P40L	VSMQGNTTSIINPKQSKDAPKSFTF	VSMQGNTTSIINLKQSKDAPKSFTF	9.0	4.0	-	-	2591_17:4904079-4904079 C>T_VSMQGNTTSIINLKQSKDAPKSFTF	0.0
10:75532594-75532594 C>A	0.0	4246	COLORECTAL	-	-	-	-	FUT11	uc001juz.1,p.T168N|NM_173540,p.T168N|uc001juy.1,p.T168N|uc001jva.3,p.T168N|ENST00000394790,p.T168N|ENST00000372841,p.T168N|NM_001284194,p.T168N	protein_coding, processed_transcript	uc001jva.3	nonsynonymous SNV	exon1	c.C503A	p.T168N	LSHGPGIRLFNLTSTFSRHSDYPLS	LSHGPGIRLFNLNSTFSRHSDYPLS	8.0	9.0	-	-	4246_10:75532594-75532594 C>A_LSHGPGIRLFNLNSTFSRHSDYPLS	0.0
1:185964096-185964096 G>A	0.0	4316	COLORECTAL	-	-	-	-	HMCN1	ENST00000367492,p.V1219I|uc001grq.1,p.V1219I|ENST00000271588,p.V1219I|NM_031935,p.V1219I	protein_coding, processed_transcript	uc001grq.1	nonsynonymous SNV	exon24	c.G3655A	p.V1219I	GGSTMLVDGEHHVSNPDGTLSIDQA	GGSTMLVDGEHHISNPDGTLSIDQA	6.0	8.0	-	-	4316_1:185964096-185964096 G>A_GGSTMLVDGEHHISNPDGTLSIDQA	0.0
7:92161819-92161819 T>G	0.0	4317	COLORECTAL	-	-	-	-	RBM48	NM_032120,p.L135R|uc003uma.3,p.L135R|ENST00000496410,p.L77R|uc003ulz.3,p.L135R|ENST00000481551,p.L135R|ENST00000265732,p.L135R|uc011khu.1,p.L135R	protein_coding	uc011khu.1	nonsynonymous SNV	exon3	c.T404G	p.L135R	PEFETVEETRKKLQMRKAYVVKTTE	PEFETVEETRKKRQMRKAYVVKTTE	6.0	4.0	-	-	4317_7:92161819-92161819 T>G_PEFETVEETRKKRQMRKAYVVKTTE	0.0
19:53014911-53014911 C>A	0.0	4266	COLORECTAL	-	-	-	-	ZNF578	uc002pzp.4,p.P426H|ENST00000421239,p.P426H|NM_001099694,p.P426H	protein_coding, processed_transcript	uc002pzp.4	nonsynonymous SNV	exon6	c.C1277A	p.P426H	LSRHHRLHTGEKPYKCNDCGKAFIH	LSRHHRLHTGEKHYKCNDCGKAFIH	3.0	4.0	-	-	4266_19:53014911-53014911 C>A_LSRHHRLHTGEKHYKCNDCGKAFIH	0.0
2:176973769-176973769 A>T	1.0	4252	COLORECTAL	-	-	-	1	HOXD11	ENST00000249504,p.T306S|uc002uki.3,p.T306S|NM_021192,p.T306S	protein_coding, processed_transcript	uc002uki.3	nonsynonymous SNV	exon2	c.A916T	p.T306S	EKRLQLSRMLNLTDRQVKIWFQNRR	EKRLQLSRMLNLSDRQVKIWFQNRR	6.0	8.0	-	-	4252_2:176973769-176973769 A>T_EKRLQLSRMLNLSDRQVKIWFQNRR	0.0
8:98289315-98289315 C>A	0.0	4213	COLORECTAL	-	-	-	-	TSPYL5	ENST00000322128,p.G253V|NM_033512,p.G253V|uc003yhy.3,p.G253V	protein_coding	uc003yhy.3	nonsynonymous SNV	exon1	c.G758T	p.G253V	RNHLIQNIPGFWGQAFQNHPQLASF	RNHLIQNIPGFWVQAFQNHPQLASF	6.0	2.0	-	-	4213_8:98289315-98289315 C>A_RNHLIQNIPGFWVQAFQNHPQLASF	0.0
1:213414834-213414834 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1689817;OCCURENCE=1(skin)	-	RPS6KC1	ENST00000543470,p.S460L|uc010ptv.2,p.S207L|uc010ptr.2,p.S672L|NM_012424,p.S672L|NM_001136138,p.S660L|ENST00000366959,p.S660L|ENST00000366960,p.S672L|uc010ptu.2,p.S491L|NM_001287221,p.S491L|NM_001287220,p.S207L|uc010pts.2,p.S460L|NM_001287219,p.S460L|NM_001287218,p.S460L|uc001hkd.3,p.S660L|ENST00000543354,p.S375L|uc010ptt.2,p.S460L|uc001hke.3,p.S491L	protein_coding, processed_transcript	uc010ptv.2	nonsynonymous SNV	exon9	c.C620T	p.S207L	ISRGSDDSVPVISFKDAAFDDVSGT	ISRGSDDSVPVILFKDAAFDDVSGT	6.0	4.0	-	-	3713_1:213414834-213414834 C>T_ISRGSDDSVPVILFKDAAFDDVSGT	0.0
3:130104133-130104133 T>G	0.0	4238	COLORECTAL	-	-	-	-	COL6A5	NM_001278298,p.V596G|uc010htk.2,p.V596G|ENST00000432398,p.V596G|ENST00000265379,p.V596G|ENST00000312481,p.V596G|NM_153264,p.V596G|uc010htj.2,p.V596G	protein_coding, nonsense_mediated_decay	uc010htk.2	nonsynonymous SNV	exon5	c.T1787G	p.V596G	IELQEIAGKEERVSFGQNFDALKSI	IELQEIAGKEERGSFGQNFDALKSI	1.0	3.0	-	-	4238_3:130104133-130104133 T>G_IELQEIAGKEERGSFGQNFDALKSI	0.0
1:237863752-237863752 G>A	0.0	4281	COLORECTAL	-	-	-	-	RYR2	uc010pxz.1,p.G73R|ENST00000360064,p.G3116R|ENST00000542537,p.G3102R|ENST00000366574,p.G3118R|NM_001035,p.G3118R|uc001hyl.1,p.G3118R	protein_coding, processed_transcript	uc010pxz.1	nonsynonymous SNV	exon4	c.G217A	p.G73R	SSLFEHIGQHQFGEDLILEDVQVSC	SSLFEHIGQHQFREDLILEDVQVSC	4.0	7.0	-	-	4281_1:237863752-237863752 G>A_SSLFEHIGQHQFREDLILEDVQVSC	0.0
16:67424869-67424869 G>A	1.0	4189	MELANOMA	-	-	-	-	TPPP3	NM_015964,p.S49F|ENST00000393957,p.S49F|NM_016140,p.S49F|uc002etb.3,p.S49F|uc002esz.3,p.S49F|ENST00000290942,p.S49F|ENST00000564104,p.S49F|ENST00000562206,p.S49F|uc002eta.3,p.S49F	retained_intron, protein_coding	uc002etb.3	nonsynonymous SNV	exon2	c.C146T	p.S49F	KLCKDCKVADGKSVTGTDVDIVFSK	KLCKDCKVADGKFVTGTDVDIVFSK	6.0	7.0	-	-	4189_16:67424869-67424869 G>A_KLCKDCKVADGKFVTGTDVDIVFSK	0.0
1:11585322-11585322 C>G	1.0	4259	COLORECTAL	-	-	-	-	PTCHD2	ENST00000294484,p.P856A|ENST00000389575,p.P856A|NM_020780,p.P856A|uc001asi.1,p.P856A|uc001ash.4,p.P856A	protein_coding, processed_transcript	uc001asi.1	nonsynonymous SNV	exon11	c.C2566G	p.P856A	VYRLSLNASLPAPWQAVSPGDGEVP	VYRLSLNASLPAAWQAVSPGDGEVP	3.0	9.0	-	-	4259_1:11585322-11585322 C>G_VYRLSLNASLPAAWQAVSPGDGEVP	0.0
16:88722107-88722107 G>A	1.0	3466	MELANOMA	-	-	-	-	MVD	uc002flg.1,p.T212I|ENST00000569177,p.T246I|NM_002461,p.T212I|uc002flf.1,p.T81I|ENST00000301012,p.T212I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002flg.1	nonsynonymous SNV	exon6	c.C635T	p.T212I	LVVSAEKKLTGSTVGMRASVETSPL	LVVSAEKKLTGSIVGMRASVETSPL	4.0	2.0	-	-	3466_16:88722107-88722107 G>A_LVVSAEKKLTGSIVGMRASVETSPL	0.0
1:156815580-156815580 C>T	0.0	3998	MELANOMA	-	-	-	-	INSRR	uc010pht.2,p.D669N|ENST00000368195,p.D669N|NM_014215,p.D669N	protein_coding	uc010pht.2	nonsynonymous SNV	exon10	c.G2005A	p.D669N	CHRGLRLPTSNNDPRFDGEDGDPEA	CHRGLRLPTSNNNPRFDGEDGDPEA	1.0	9.0	-	-	3998_1:156815580-156815580 C>T_CHRGLRLPTSNNNPRFDGEDGDPEA	0.0
1:148346658-148346658 C>A	1.0	4326	BREAST	-	-	-	-	NBPF14,NBPF8,NBPF9	uc031pon.1,p.Q33H|NM_001277444,p.Q33H	protein_coding	uc031pon.1	nonsynonymous SNV	exon2	c.G99T	p.Q33H	NEKLRPQLAENKQQFGNLKERCFLT	NEKLRPQLAENKHQFGNLKERCFLT	10.0	7.0	-	-	4326_1:148346658-148346658 C>A_NEKLRPQLAENKHQFGNLKERCFLT	0.0
7:72858409-72858409 C>T	1.0	4317	COLORECTAL	-	-	-	-	BAZ1B	uc003tyc.3,p.A1299T|ENST00000404251,p.A1299T|NM_032408,p.A1299T|ENST00000339594,p.A1299T	retained_intron, protein_coding	uc003tyc.3	nonsynonymous SNV	exon17	c.G3895A	p.A1299T	TIRGKHSVIPPAARSGRRPGKKPHS	TIRGKHSVIPPATRSGRRPGKKPHS	8.0	5.0	-	-	4317_7:72858409-72858409 C>T_TIRGKHSVIPPATRSGRRPGKKPHS	0.0
X:122599628-122599628 G>A	0.0	4316	COLORECTAL	-	-	-	-	GRIA3	ENST00000542149,p.G810S	protein_coding, processed_transcript	ENST00000542149	nonsynonymous SNV	exon14	c.G2428A	p.G810S	WWYDKGECGSGGGDSKNACKPCSIE	WWYDKGECGSGGSDSKNACKPCSIE	2.0	6.0	-	-	4316_X:122599628-122599628 G>A_WWYDKGECGSGGSDSKNACKPCSIE	0.0
15:51783797-51783797 G>A	0.0	4158	COLORECTAL	-	-	-	-	DMXL2	ENST00000449909,p.T1008M|NM_001174117,p.T1008M|uc010ufy.2,p.T1644M|NM_001174116,p.T1644M|NM_015263,p.T1644M|uc010bfa.3,p.T1008M|ENST00000543779,p.T1644M|uc002abf.3,p.T1644M|ENST00000251076,p.T1644M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ufy.2	nonsynonymous SNV	exon20	c.C4931T	p.T1644M	AMGIGWWVRNINTLRRCIEKVAKAS	AMGIGWWVRNINMLRRCIEKVAKAS	7.0	6.0	-	-	4158_15:51783797-51783797 G>A_AMGIGWWVRNINMLRRCIEKVAKAS	0.0
17:76450615-76450615 C>T	0.0	3795	MELANOMA	-	-	ID=COSM1710851;OCCURENCE=1(skin)	-	DNAH17	NM_173628,p.G3448E|uc010dhp.2,p.G3448E|ENST00000389840,p.G3434E|ENST00000585328,p.G3443E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dhp.2	nonsynonymous SNV	exon64	c.G10343A	p.G3448E	ERWPLIVDAQLQGIKWIKNKYRSEL	ERWPLIVDAQLQEIKWIKNKYRSEL	2.0	10.0	-	-	3795_17:76450615-76450615 C>T_ERWPLIVDAQLQEIKWIKNKYRSEL	0.0
4:62897173-62897173 G>T	0.0	4110	BILE DUCT	-	-	-	-	LPHN3	ENST00000506746,p.G1137C|ENST00000506700,p.G1069C|ENST00000507164,p.G1137C|ENST00000514996,p.G1069C|ENST00000514157,p.G1069C|ENST00000511324,p.G1137C|uc003hct.3,p.G462C|ENST00000507625,p.G1137C	retained_intron, protein_coding, processed_transcript	uc003hct.3	nonsynonymous SNV	exon10	c.G1384T	p.G462C	SGCLDNIKSWVIGAIALLCLLGLTW	SGCLDNIKSWVICAIALLCLLGLTW	1.0	7.0	-	-	4110_4:62897173-62897173 G>T_SGCLDNIKSWVICAIALLCLLGLTW	0.0
17:10406444-10406444 G>C	0.0	4346	COLORECTAL	-	-	-	-	MYH1	uc002gmo.3,p.A938G|ENST00000226207,p.A938G|NM_005963,p.A938G	protein_coding	uc002gmo.3	nonsynonymous SNV	exon23	c.C2813G	p.A938G	VTERAEDEEEINAELTAKKRKLEDE	VTERAEDEEEINGELTAKKRKLEDE	1.0	7.0	-	-	4346_17:10406444-10406444 G>C_VTERAEDEEEINGELTAKKRKLEDE	0.0
5:176023834-176023834 G>-	0.0	4189	MELANOMA	-	-	-	-	GPRIN1	uc021yif.1,p.S1001fs|NM_052899,p.S1001fs|uc003meo.1,p.S1001fs|ENST00000303991,p.S1001fs	protein_coding	uc021yif.1	frameshift deletion	exon1	c.3002delC	p.S1001fs	ALLQSVRRPRCCSRAGPTAE	ALLQSVRRPRCCCGRDPRPS	4.0	10.0	-	-	4189_5:176023834-176023834 G>-_ALLQSVRRPRCCCGRDPRPS	0.0
10:122630798-122630798 C>T	1.0	3466	MELANOMA	-	-	ID=COSM915456;OCCURENCE=2(endometrium)	-	WDR11	ENST00000263461,p.R471C|NM_018117,p.R471C|uc010qte.2,p.R73C|uc021pzt.1,p.R471C|ENST00000604585,p.R212C	protein_coding, processed_transcript	uc021pzt.1	nonsynonymous SNV	exon10	c.C1411T	p.R471C	LLSGLPAPQFAIRMCPPLTTKNIKM	LLSGLPAPQFAICMCPPLTTKNIKM	9.0	7.0	-	-	3466_10:122630798-122630798 C>T_LLSGLPAPQFAICMCPPLTTKNIKM	0.0
7:44579272-44579272 G>A	0.0	4095	COLORECTAL	-	-	-	-	NPC1L1	NM_001101648,p.R242C|uc011kbw.2,p.R242C|NM_013389,p.R242C|ENST00000381160,p.R242C|uc003tlc.3,p.R242C|uc003tlb.3,p.R242C|ENST00000546276,p.R242C|NM_001300967,p.R242C|ENST00000423141,p.R242C|uc003tld.3,p.R242C|ENST00000289547,p.R242C	protein_coding	uc011kbw.2	nonsynonymous SNV	exon2	c.C724T	p.R242C	GSGIQPLNEGVARCNESQGDDVATC	GSGIQPLNEGVACCNESQGDDVATC	3.0	8.0	-	-	4095_7:44579272-44579272 G>A_GSGIQPLNEGVACCNESQGDDVATC	0.0
16:30750384-30750384 G>T	0.0	3919	MELANOMA	-	-	-	-	SRCAP	NM_006662,p.G3008V|ENST00000380361,p.G2831V|uc002dzg.1,p.G2803V|ENST00000262518,p.G3008V|ENST00000344771,p.G2850V|ENST00000395059,p.G2946V|uc002dze.1,p.G3008V	retained_intron, protein_coding, nonsense_mediated_decay	uc002dzg.1	nonsynonymous SNV	exon29	c.G8408T	p.G2803V	VTISTSPPKRKRGRPPKNPPSPRPS	VTISTSPPKRKRVRPPKNPPSPRPS	9.0	2.0	-	-	3919_16:30750384-30750384 G>T_VTISTSPPKRKRVRPPKNPPSPRPS	0.0
20:33934891-33934891 T>C	1.0	3713	MELANOMA	-	-	-	-	UQCC1	ENST00000397554,p.K217E|uc002xci.1,p.K171E|uc010gfd.2,p.K203E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010gfd.2	nonsynonymous SNV	exon7	c.A607G	p.K203E	REGFEFGVLSVVKWPCF	REGFEFGVLSVVEWPCF	10.0	9.0	-	-	3713_20:33934891-33934891 T>C_REGFEFGVLSVVEWPCF	0.0
4:68490723-68490723 C>T	1.0	2369	MELANOMA	-	-	-	-	UBA6	uc003hdg.4,p.V901I|ENST00000322244,p.V901I|NM_018227,p.V901I	retained_intron, protein_coding, nonsense_mediated_decay	uc003hdg.4	nonsynonymous SNV	exon29	c.G2701A	p.V901I	KIIPAIATTTATVSGLVALEMIKVT	KIIPAIATTTATISGLVALEMIKVT	7.0	9.0	-	-	2369_4:68490723-68490723 C>T_KIIPAIATTTATISGLVALEMIKVT	0.0
19:47260044-47260044 T>G	1.0	4134	NSCLC	-	-	-	-	FKRP	uc002pfp.2,p.L446R|uc002pfn.2,p.L446R|ENST00000318584,p.L446R|NM_001039885,p.L446R|NM_024301,p.L446R|uc021uwj.1,p.L446R|ENST00000391909,p.L446R	retained_intron, protein_coding, processed_transcript	uc021uwj.1	nonsynonymous SNV	exon1	c.T1337G	p.L446R	DHRQDVEFPEHFLQPLVPLPFAGFV	DHRQDVEFPEHFRQPLVPLPFAGFV	5.0	9.0	-	-	4134_19:47260044-47260044 T>G_DHRQDVEFPEHFRQPLVPLPFAGFV	0.0
9:43627176-43627176 G>T	0.0	4298	COLORECTAL	-	-	ID=COSM608783;OCCURENCE=1(lung)	-	SPATA31A6	uc011lrb.2,p.P504Q|NM_001145196,p.P504Q|ENST00000332857,p.P504Q	protein_coding, processed_transcript	uc011lrb.2	nonsynonymous SNV	exon4	c.C1511A	p.P504Q	QAEAQAHLQSSFPVLSPAFPSLIKN	QAEAQAHLQSSFQVLSPAFPSLIKN	4.0	7.0	-	-	4298_9:43627176-43627176 G>T_QAEAQAHLQSSFQVLSPAFPSLIKN	0.0
20:18608800-18608800 C>T	1.0	4180	BREAST	-	-	-	-	DTD1	ENST00000377452,p.H134Y|uc002wrf.4,p.H134Y|NM_080820,p.H134Y	protein_coding, processed_transcript	uc002wrf.4	nonsynonymous SNV	exon4	c.C400T	p.H134Y	IKDGKFGAYMQVHIQNDGPVTIELE	IKDGKFGAYMQVYIQNDGPVTIELE	9.0	8.0	-	-	4180_20:18608800-18608800 C>T_IKDGKFGAYMQVYIQNDGPVTIELE	0.0
1:39759215-39759215 A>G	1.0	4335	COLORECTAL	-	-	-	-	MACF1	ENST00000564288,p.E693G|ENST00000361689,p.E698G|uc001cda.1,p.E606G|ENST00000567887,p.E730G|uc031pmc.1,p.E698G|uc021olt.1,p.E698G|uc001cdc.2,p.E698G|ENST00000539005,p.E698G|ENST00000372915,p.E698G|ENST00000545844,p.E698G|ENST00000496804,p.E858G|ENST00000317713,p.E698G|ENST00000530262,p.E847G|ENST00000524432,p.E656G|NM_012090,p.E698G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pmc.1	nonsynonymous SNV	exon17	c.A2093G	p.E698G	VSRATAELIWLNEKEEEELAYDWSD	VSRATAELIWLNGKEEEELAYDWSD	10.0	3.0	-	-	4335_1:39759215-39759215 A>G_VSRATAELIWLNGKEEEELAYDWSD	0.0
13:101936359-101936359 T>G	0.0	4278	COLORECTAL	-	-	ID=COSM1365222;OCCURENCE=1(large_intestine)	-	NALCN	NM_052867,p.E353D|ENST00000376196,p.E353D|uc001voz.2,p.E353D|ENST00000251127,p.E353D|uc001voy.3,p.E68D|uc001vpa.2,p.E353D|uc001vox.1,p.E353D	retained_intron, protein_coding, processed_transcript	uc001vpa.2	nonsynonymous SNV	exon10	c.A1059C	p.E353D	STTSTATTQMFHEDAAGGWQLVAVD	STTSTATTQMFHDDAAGGWQLVAVD	6.0	1.0	-	-	4278_13:101936359-101936359 T>G_STTSTATTQMFHDDAAGGWQLVAVD	0.0
2:189434788-189434788 A>-	1.0	4078	GASTRIC	-	-	-	-	GULP1	ENST00000409805,p.K81fs|uc010zfw.2,p.K81fs|uc002uqg.3,p.K184fs|ENST00000409830,p.K184fs|NM_001252669,p.K81fs|uc002uqf.3,p.K184fs|NM_001252668,p.K184fs|uc002uqd.3,p.K184fs|ENST00000359135,p.K184fs|uc010fru.3,p.K184fs|ENST00000409843,p.K184fs|NM_016315,p.K184fs|ENST00000409609,p.K184fs|ENST00000409580,p.K184fs	retained_intron, protein_coding, processed_transcript	uc010zfw.2	frameshift deletion	exon6	c.241delA	p.K81fs	RIQDLETENMELKNKVQDLENQLRI	RIQDLETENMELKIKYKIWKTN	9.0	5.0	-	-	4078_2:189434788-189434788 A>-_RIQDLETENMELKIKYKIWKTN	0.0
15:88669548-88669548 G>T	0.0	4316	COLORECTAL	-	-	-	1	NTRK3	ENST00000357724,p.F442L|uc002bmh.2,p.F442L|ENST00000560017,p.F54L|ENST00000355254,p.F450L|uc010bnh.1,p.F442L|uc002bme.2,p.F450L|ENST00000317501,p.F450L|uc002bmg.3,p.F450L|uc021sua.1,p.F442L|NM_001012338,p.F450L|NM_001007156,p.F450L|uc002bmf.2,p.F450L|ENST00000394480,p.F450L|ENST00000558676,p.F442L|ENST00000540489,p.F450L|NM_002530,p.F450L|ENST00000542733,p.F352L|uc010upl.1,p.F352L|NM_001243101,p.F442L|ENST00000557856,p.F442L|ENST00000360948,p.F450L	protein_coding, processed_transcript	uc021sua.1	nonsynonymous SNV	exon12	c.C1326A	p.F442L	LAAFACVLLVVLFVMINKYGRRSKF	LAAFACVLLVVLLVMINKYGRRSKF	5.0	5.0	-	-	4316_15:88669548-88669548 G>T_LAAFACVLLVVLLVMINKYGRRSKF	0.0
10:89692850-89692850 C>G	0.0	4238	COLORECTAL	-	-	ID=COSM5199;OCCURENCE=2(central_nervous_system),3(endometrium)	1	PTEN	NM_000314,p.L112V|ENST00000371953,p.L112V|uc001kfb.3,p.L112V	protein_coding, processed_transcript	uc001kfb.3	nonsynonymous SNV	exon5	c.C334G	p.L112V	LIKPFCEDLDQWLSEDDNHVAAIHC	LIKPFCEDLDQWVSEDDNHVAAIHC	8.0	10.0	-	-	4238_10:89692850-89692850 C>G_LIKPFCEDLDQWVSEDDNHVAAIHC	0.0
5:1443228-1443228 C>A	0.0	4110	BILE DUCT	-	-	-	-	SLC6A3	ENST00000270349,p.V29L|uc003jck.3,p.V29L|ENST00000453492,p.V29L|NM_001044,p.V29L	retained_intron, protein_coding	uc003jck.3	nonsynonymous SNV	exon2	c.G85T	p.V29L	PAKEPNAVGPKEVELILVKEQNGVQ	PAKEPNAVGPKELELILVKEQNGVQ	4.0	6.0	-	-	4110_5:1443228-1443228 C>A_PAKEPNAVGPKELELILVKEQNGVQ	0.0
X:148579752-148579752 G>T	0.0	4129	NSCLC	-	-	-	-	IDS	ENST00000370443,p.D198E|uc011mxf.2,p.D108E|uc011mxe.2,p.D198E|NM_000202,p.D198E|ENST00000340855,p.D198E|uc011mxh.2,p.D198E|NM_006123,p.D198E|NM_001166550,p.D108E|ENST00000370441,p.D198E|ENST00000466323,p.D198E	protein_coding, processed_transcript, nonsense_mediated_decay	uc011mxh.2	nonsynonymous SNV	exon5	c.C594A	p.D198E	VDVLDVPEGTLPDKQSTEQAIQLLE	VDVLDVPEGTLPEKQSTEQAIQLLE	8.0	9.0	-	-	4129_X:148579752-148579752 G>T_VDVLDVPEGTLPEKQSTEQAIQLLE	0.0
20:18496337-18496337 C>T	1.0	3716	MELANOMA	-	-	-	-	SEC23B	ENST00000377465,p.A108V|uc010zsb.2,p.A108V|NM_006363,p.A108V|uc002wqz.2,p.A108V|ENST00000336714,p.A108V|uc002wrc.2,p.A108V|NM_032986,p.A108V|ENST00000450074,p.A108V|ENST00000377475,p.A108V|ENST00000262544,p.A108V|NM_001172745,p.A108V|uc002wrb.2,p.A108V|uc002wra.2,p.A108V|NM_001172746,p.A108V|NM_032985,p.A108V	protein_coding, processed_transcript	uc010zsb.2	nonsynonymous SNV	exon4	c.C323T	p.A108V	PAYGGISEVNQPAELMPQFSTIEYV	PAYGGISEVNQPVELMPQFSTIEYV	7.0	8.0	-	-	3716_20:18496337-18496337 C>T_PAYGGISEVNQPVELMPQFSTIEYV	0.0
5:175533088-175533088 G>C	0.0	4326	BREAST	-	rs4613734	-	-	FAM153B	uc031smc.1,p.V263L|ENST00000508296,p.V186L|NM_001265615,p.V186L|ENST00000515817,p.V186L|ENST00000253490,p.V263L|ENST00000512862,p.V54L|uc031sma.1,p.V54L|uc031smd.1,p.V52L|ENST00000510151,p.V186L|uc031smb.1,p.V186L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031smd.1	nonsynonymous SNV	exon5	c.G154C	p.V52L	PQRGDLEDLEEHVPGQTVSEEATGV	PQRGDLEDLEEHLPGQTVSEEATGV	5.0	6.0	-	-	4326_5:175533088-175533088 G>C_PQRGDLEDLEEHLPGQTVSEEATGV	0.0
15:84527554-84527554 G>A	0.0	4252	COLORECTAL	-	-	-	-	ADAMTSL3	uc002bjy.1,p.R255Q|ENST00000286744,p.R255Q|uc010bmt.1,p.R255Q|NM_001301110,p.R255Q|NM_207517,p.R255Q|ENST00000567476,p.R255Q|uc002bjz.4,p.R255Q	retained_intron, protein_coding, processed_transcript	uc010bmt.1	nonsynonymous SNV	exon8	c.G764A	p.R255Q	REENVIAVPLGSRSVRITVKGPAHL	REENVIAVPLGSQSVRITVKGPAHL	4.0	10.0	-	-	4252_15:84527554-84527554 G>A_REENVIAVPLGSQSVRITVKGPAHL	0.0
17:70119866-70119866 G>A	1.0	3713	MELANOMA	-	-	-	-	SOX9	NM_000346,p.D290N|ENST00000245479,p.D290N|uc002jiw.3,p.D290N	protein_coding	uc002jiw.3	nonsynonymous SNV	exon3	c.G868A	p.D290N	LSSDVISNIETFDVNEFDQYLPPNG	LSSDVISNIETFNVNEFDQYLPPNG	2.0	2.0	-	-	3713_17:70119866-70119866 G>A_LSSDVISNIETFNVNEFDQYLPPNG	0.0
15:88472566-88472566 G>C	0.0	4213	COLORECTAL	-	-	-	1	NTRK3	uc010bnh.1,p.I655M|uc002bmf.2,p.I663M|NM_001012338,p.I663M|uc002bme.2,p.I663M|ENST00000557856,p.I655M|NM_002530,p.I663M|ENST00000357724,p.I655M|ENST00000542733,p.I565M|ENST00000360948,p.I663M|ENST00000355254,p.I663M|ENST00000558676,p.I655M|uc021sua.1,p.I655M|uc002bmh.2,p.I655M|NM_001243101,p.I655M|ENST00000394480,p.I663M|uc010upl.1,p.I565M	protein_coding, processed_transcript	uc021sua.1	nonsynonymous SNV	exon16	c.C1965G	p.I655M	LGLSQMLHIASQIASGMVYLASQHF	LGLSQMLHIASQMASGMVYLASQHF	7.0	8.0	-	-	4213_15:88472566-88472566 G>C_LGLSQMLHIASQMASGMVYLASQHF	0.0
5:140594035-140594035 C>T	1.0	4000	MELANOMA	-	-	-	-	PCDHB13	NM_018933,p.P114S|ENST00000341948,p.P114S|uc003lja.1,p.P114S	protein_coding	uc003lja.1	nonsynonymous SNV	exon1	c.C340T	p.P114S	PCVLRFQVLLESPFEFFQAELQVID	PCVLRFQVLLESSFEFFQAELQVID	4.0	10.0	-	-	4000_5:140594035-140594035 C>T_PCVLRFQVLLESSFEFFQAELQVID	0.0
1:55266772-55266772 G>A	1.0	3775	CERVICAL	-	-	-	-	TTC22	NM_001114108,p.P22L|uc001cxz.4,p.P22L|ENST00000371276,p.P22L|uc009vzt.1,p.P22L|NM_017904,p.P22L|ENST00000371274,p.P22L	retained_intron, protein_coding	uc009vzt.1	nonsynonymous SNV	exon1	c.C65T	p.P22L	DLDALIDDLDYLPGHFHLEMQLNFE	DLDALIDDLDYLLGHFHLEMQLNFE	6.0	8.0	-	-	3775_1:55266772-55266772 G>A_DLDALIDDLDYLLGHFHLEMQLNFE	0.0
15:74631600-74631600 C>T	0.0	4110	BILE DUCT	-	-	-	-	CYP11A1	uc002axt.2,p.R405Q|uc002axs.2,p.R247Q|uc010bjn.2,p.R128Q|ENST00000358632,p.R247Q|uc010bjm.1,p.R247Q|ENST00000268053,p.R405Q|NM_001099773,p.R247Q|ENST00000419019,p.R247Q|NM_000781,p.R405Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bjn.2	nonsynonymous SNV	exon6	c.G383A	p.R128Q	TLQRYLVNDLVLRDYMIPAKTLVQV	TLQRYLVNDLVLQDYMIPAKTLVQV	2.0	8.0	-	-	4110_15:74631600-74631600 C>T_TLQRYLVNDLVLQDYMIPAKTLVQV	0.0
2:71220866-71220866 T>C	1.0	2369	MELANOMA	-	-	-	-	TEX261	uc002shn.3,p.Y37C|NM_144582,p.Y37C|ENST00000433258,p.Y37C|ENST00000606025,p.Y37C|ENST00000272438,p.Y37C	 processed_transcript, nonsense_mediated_decay,retained_intron, protein_coding	uc002shn.3	nonsynonymous SNV	exon2	c.A110G	p.Y37C	AGLYYLAELIEEYTVATSRIIKYMI	AGLYYLAELIEECTVATSRIIKYMI	8.0	7.0	-	-	2369_2:71220866-71220866 T>C_AGLYYLAELIEECTVATSRIIKYMI	0.0
2:206614520-206614520 G>A	1.0	4287	COLORECTAL	-	-	-	-	NRP2	uc002vay.3,p.E620K|ENST00000360409,p.E620K|NM_201279,p.E620K|uc002vau.3,p.E620K|NM_003872,p.E620K|ENST00000540841,p.E620K|NM_201267,p.E620K|NM_201266,p.E620K|uc002vax.3,p.E620K|ENST00000412873,p.E620K|ENST00000357785,p.E620K|ENST00000540178,p.E620K|NM_018534,p.E620K|ENST00000357118,p.E620K|ENST00000272849,p.E620K|uc002vav.3,p.E620K|uc002vaw.3,p.E620K	retained_intron, protein_coding, processed_transcript	uc002vay.3	nonsynonymous SNV	exon11	c.G1858A	p.E620K	VKSEETTTPYPTEEEATECGENCSF	VKSEETTTPYPTKEEATECGENCSF	7.0	9.0	-	-	4287_2:206614520-206614520 G>A_VKSEETTTPYPTKEEATECGENCSF	0.0
12:120599720-120599720 G>A	1.0	3713	MELANOMA	-	-	-	-	GCN1L1	ENST00000300648,p.P769L|uc001txo.3,p.P769L|NM_006836,p.P769L	retained_intron, protein_coding	uc001txo.3	nonsynonymous SNV	exon21	c.C2306T	p.P769L	LVTREEFAIMQTPAGELYDKSIIQS	LVTREEFAIMQTLAGELYDKSIIQS	6.0	4.0	CD8	-	3713_12:120599720-120599720 G>A_LVTREEFAIMQTLAGELYDKSIIQS	1.0
15:41797669-41797669 C>T	1.0	4136	BREAST	0.0005	-	-	-	LTK	NM_206961,p.R525H|uc010ucx.1,p.R456H|uc001zob.3,p.R525H|ENST00000453182,p.R456H|ENST00000355166,p.R525H|NM_001135685,p.R456H|ENST00000561619,p.R284H|ENST00000263800,p.R586H|uc001zoa.3,p.R586H|uc010bcg.2,p.R284H|NM_002344,p.R586H	retained_intron, protein_coding	uc010ucx.1	nonsynonymous SNV	exon12	c.G1367A	p.R456H	VRCVGLSLRATPRLILLELMSGGDM	VRCVGLSLRATPHLILLELMSGGDM	5.0	10.0	-	-	4136_15:41797669-41797669 C>T_VRCVGLSLRATPHLILLELMSGGDM	0.0
3:43097768-43097768 G>A	0.0	4346	COLORECTAL	-	-	-	-	FAM198A	uc003cmp.4,p.G540R|ENST00000273146,p.G540R|NM_001129908,p.G540R|ENST00000430121,p.G540R|ENST00000488863,p.G111R	retained_intron, protein_coding, nonsense_mediated_decay	uc003cmp.4	nonsynonymous SNV	exon5	c.G1618A	p.G540R	LQMDPVFWESQGGAQGLKQVLQTLE	LQMDPVFWESQGRAQGLKQVLQTLE	2.0	8.0	-	-	4346_3:43097768-43097768 G>A_LQMDPVFWESQGRAQGLKQVLQTLE	0.0
19:50824024-50824024 C>T	1.0	3716	MELANOMA	-	-	-	-	KCNC3	uc002prt.1,p.D302N|ENST00000477616,p.D666N|uc002pru.1,p.D666N|ENST00000376959,p.D666N|NM_004977,p.D666N	protein_coding	uc002pru.1	nonsynonymous SNV	exon3	c.G1996A	p.D666N	IEINRADPRPNGDPAAAALAHEDCP	IEINRADPRPNGNPAAAALAHEDCP	2.0	10.0	-	-	3716_19:50824024-50824024 C>T_IEINRADPRPNGNPAAAALAHEDCP	0.0
7:42007425-42007425 C>A	0.0	4077	BILE DUCT	-	-	-	-	GLI3	uc011kbh.2,p.D734Y|ENST00000395925,p.D734Y|uc011kbg.2,p.D675Y|NM_000168,p.D734Y	retained_intron, protein_coding, processed_transcript	uc011kbh.2	nonsynonymous SNV	exon14	c.G2200T	p.D734Y	NYSNSGLELPLTDGGSIGDLSAIDE	NYSNSGLELPLTYGGSIGDLSAIDE	6.0	5.0	-	-	4077_7:42007425-42007425 C>A_NYSNSGLELPLTYGGSIGDLSAIDE	0.0
17:1960105-1960105 G>A	0.0	4335	COLORECTAL	-	-	-	-	HIC1	ENST00000322941,p.A60T|uc002ftz.4,p.A41T|NM_001098202,p.A60T|ENST00000399849,p.A41T|uc002fty.4,p.A41T|uc021tnn.1,p.A41T|ENST00000571990,p.A41T|NM_006497,p.A41T|uc010cjy.3,p.A60T|ENST00000576444,p.A41T	protein_coding, processed_transcript	uc021tnn.1	nonsynonymous SNV	exon1	c.G121A	p.A41T	DVIIVVQNALFRAHKNVLAASSAYL	DVIIVVQNALFRTHKNVLAASSAYL	5.0	10.0	-	-	4335_17:1960105-1960105 G>A_DVIIVVQNALFRTHKNVLAASSAYL	0.0
3:197544140-197544140 A>C	0.0	4245	COLORECTAL	-	-	-	-	LRCH3	uc011bum.1,p.E167D|ENST00000334859,p.E167D|ENST00000425562,p.E167D|NM_032773,p.E167D|ENST00000438796,p.E167D|uc011bul.1,p.E167D|ENST00000414675,p.E167D|uc003fyj.1,p.E167D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bum.1	nonsynonymous SNV	exon3	c.A501C	p.E167D	LIASNNKLVSLPEEIGHLRHLMELD	LIASNNKLVSLPDEIGHLRHLMELD	8.0	2.0	-	-	4245_3:197544140-197544140 A>C_LIASNNKLVSLPDEIGHLRHLMELD	0.0
8:82583178-82583178 G>A	1.0	4000	MELANOMA	-	-	-	-	IMPA1	NM_001144878,p.H247Y|ENST00000449740,p.H247Y|ENST00000256108,p.H188Y|uc011lfq.1,p.H247Y|NM_005536,p.H188Y|uc003ych.2,p.H188Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lfq.1	nonsynonymous SNV	exon8	c.C739T	p.H247Y	LSNMEKLFCIPVHGIRSVGTAAVNM	LSNMEKLFCIPVYGIRSVGTAAVNM	9.0	2.0	-	-	4000_8:82583178-82583178 G>A_LSNMEKLFCIPVYGIRSVGTAAVNM	0.0
4:109774059-109774059 G>A	0.0	4287	COLORECTAL	-	-	-	-	COL25A1	NM_198721,p.T448M|uc003hzg.4,p.T448M|uc021xqp.2,p.T448M|ENST00000494183,p.T376M|ENST00000399126,p.T448M|uc003hze.2,p.T448M|NM_032518,p.T448M|ENST00000399132,p.T448M|uc021xqo.1,p.T448M	retained_intron, protein_coding, nonsense_mediated_decay	uc021xqp.2	nonsynonymous SNV	exon24	c.C1343T	p.T448M	HEALQRITTLTVTGPPGPPGPQGLQ	HEALQRITTLTVMGPPGPPGPQGLQ	2.0	9.0	-	-	4287_4:109774059-109774059 G>A_HEALQRITTLTVMGPPGPPGPQGLQ	0.0
2:219269106-219269106 C>G	1.0	4326	BREAST	-	-	-	-	CTDSP1	uc002vhz.3,p.D107E|NM_001206878,p.D247E|ENST00000273062,p.D248E|NM_182642,p.D247E|ENST00000443891,p.D247E|uc002vhx.3,p.D247E|uc002vhy.3,p.D248E|uc021vwv.1,p.D247E|NM_021198,p.D248E	retained_intron, protein_coding, processed_transcript	uc021vwv.1	nonsynonymous SNV	exon7	c.C741G	p.D247E	DLLPFFEQLSRVDDVYSVLRQPRPG	DLLPFFEQLSRVEDVYSVLRQPRPG	8.0	8.0	-	-	4326_2:219269106-219269106 C>G_DLLPFFEQLSRVEDVYSVLRQPRPG	0.0
14:105413454-105413454 G>C	1.0	4266	COLORECTAL	-	-	-	-	AHNAK2	NM_138420,p.S2778R|uc001ypx.2,p.S2678R|uc010axc.1,p.S2778R|ENST00000333244,p.S2778R	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.C8334G	p.S2778R	EVTAPDVKMSLSSMEVDVQAPRAKL	EVTAPDVKMSLSRMEVDVQAPRAKL	9.0	9.0	-	-	4266_14:105413454-105413454 G>C_EVTAPDVKMSLSRMEVDVQAPRAKL	0.0
17:74287468-74287468 G>A	1.0	2591	MELANOMA	-	-	-	-	QRICH2	uc002jrd.1,p.R948C|NM_032134,p.R948C|ENST00000262765,p.R948C	protein_coding, nonsense_mediated_decay	uc002jrd.1	nonsynonymous SNV	exon4	c.C2842T	p.R948C	LFDSHDSMYPGYRGPGYLSADQHGQ	LFDSHDSMYPGYCGPGYLSADQHGQ	4.0	4.0	-	-	2591_17:74287468-74287468 G>A_LFDSHDSMYPGYCGPGYLSADQHGQ	0.0
10:74097970-74097970 T>C	1.0	4071	COLORECTAL	-	-	-	-	DNAJB12	ENST00000394903,p.S309G|NM_017626,p.S309G|ENST00000338820,p.S309G|uc001jsz.2,p.S309G|uc001jta.2,p.S309G|uc010qjv.1,p.S309G|ENST00000444643,p.S275G|NM_001002762,p.S309G	retained_intron, protein_coding, processed_transcript	uc010qjv.1	nonsynonymous SNV	exon6	c.A925G	p.S309G	SQLMVSSPPYSLSPRPSVGHIHRRV	SQLMVSSPPYSLGPRPSVGHIHRRV	7.0	6.0	-	-	4071_10:74097970-74097970 T>C_SQLMVSSPPYSLGPRPSVGHIHRRV	0.0
7:65557846-65557846 G>A	1.0	4160	COLORECTAL	-	-	-	-	ASL	ENST00000380839,p.V422I|ENST00000395332,p.V448I|ENST00000304874,p.V448I|uc003tuo.3,p.V448I|NM_000048,p.V448I|uc003tuq.3,p.V428I|NM_001024944,p.V428I|NM_001024943,p.V448I|ENST00000395331,p.V428I|NM_001024946,p.V422I|uc003tur.3,p.V422I|uc003tup.3,p.V448I	retained_intron, protein_coding, processed_transcript	uc003tur.3	nonsynonymous SNV	exon15	c.G1264A	p.V422I	QYGALGGTARSSVDWQIRQVRALLQ	QYGALGGTARSSIDWQIRQVRALLQ	10.0	1.0	-	-	4160_7:65557846-65557846 G>A_QYGALGGTARSSIDWQIRQVRALLQ	0.0
17:80373484-80373484 G>A	1.0	3678	MELANOMA	-	-	-	-	OGFOD3	NM_175902,p.P32S|ENST00000329197,p.P32S|NM_024648,p.P32S|ENST00000580445,p.P32S|uc002ket.2,p.P32S|uc002keu.2,p.P32S|ENST00000313056,p.P32S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002keu.2	nonsynonymous SNV	exon2	c.C94T	p.P32S	RRNRSSTKKDRAPREVQRLWQRPWL	RRNRSSTKKDRASREVQRLWQRPWL	8.0	7.0	-	-	3678_17:80373484-80373484 G>A_RRNRSSTKKDRASREVQRLWQRPWL	0.0
3:124485105-124485105 C>T	1.0	3466	MELANOMA	-	-	-	-	ITGB5	NM_002213,p.G702E|ENST00000296181,p.G702E|uc003eho.3,p.G702E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eho.3	nonsynonymous SNV	exon13	c.G2105A	p.G702E	CVMMFTYVELPSGKSNLTVLREPEC	CVMMFTYVELPSEKSNLTVLREPEC	10.0	6.0	-	-	3466_3:124485105-124485105 C>T_CVMMFTYVELPSEKSNLTVLREPEC	0.0
15:45427464-45427464 G>A	0.0	4301	MELANOMA	-	-	-	-	DUOX1	ENST00000561220,p.R157Q|ENST00000321429,p.R157Q|NM_017434,p.R157Q|ENST00000389037,p.R157Q|uc001zus.1,p.R157Q|uc001zut.1,p.R157Q|NM_175940,p.R157Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zut.1	nonsynonymous SNV	exon5	c.G470A	p.R157Q	PFQRSRWDPETGRSPSNPRDPANQV	PFQRSRWDPETGQSPSNPRDPANQV	5.0	2.0	-	-	4301_15:45427464-45427464 G>A_PFQRSRWDPETGQSPSNPRDPANQV	0.0
6:90305717-90305717 T>G	0.0	4345	COLORECTAL	-	-	-	-	ANKRD6	uc010kcd.3,p.L68R|NM_014942,p.L68R|uc011dzy.2,p.L68R|ENST00000520458,p.L68R|ENST00000485637,p.L68R|uc003pne.4,p.L68R|ENST00000520793,p.L68R|ENST00000447838,p.L68R|ENST00000369408,p.L68R|uc003pnf.4,p.L68R|NM_001242814,p.L68R|NM_001242811,p.L68R|uc003pni.4,p.L68R|NM_001242813,p.L68R|ENST00000522705,p.L68R|ENST00000523798,p.L68R|ENST00000522441,p.L68R|ENST00000465722,p.L68R|ENST00000339746,p.L68R|NM_001242809,p.L68R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011dzy.2	nonsynonymous SNV	exon3	c.T203G	p.L68R	PVVQILLKAGCDLDVQDDGDQTALH	PVVQILLKAGCDRDVQDDGDQTALH	5.0	4.0	-	-	4345_6:90305717-90305717 T>G_PVVQILLKAGCDRDVQDDGDQTALH	0.0
1:110149038-110149038 C>T	1.0	4000	MELANOMA	-	-	ID=COSM200981;OCCURENCE=2(skin),1(large_intestine)	-	GNAT2	uc001dya.3,p.R161Q|ENST00000351050,p.R161Q|NM_005272,p.R161Q	protein_coding	uc001dya.3	nonsynonymous SNV	exon5	c.G482A	p.R161Q	NDSASYYLNQLERITDPEYLPSEQD	NDSASYYLNQLEQITDPEYLPSEQD	3.0	8.0	-	-	4000_1:110149038-110149038 C>T_NDSASYYLNQLEQITDPEYLPSEQD	0.0
4:79437012-79437012 C>T	1.0	4301	MELANOMA	0.0014	-	-	-	FRAS1	uc003hlb.2,p.R3412C|ENST00000264895,p.R3412C|NM_025074,p.R3412C	retained_intron, protein_coding, nonsense_mediated_decay	uc003hlb.2	nonsynonymous SNV	exon66	c.C10234T	p.R3412C	VYDSTALGPGYDRPFQFDPSVREPK	VYDSTALGPGYDCPFQFDPSVREPK	6.0	6.0	-	-	4301_4:79437012-79437012 C>T_VYDSTALGPGYDCPFQFDPSVREPK	0.0
19:53453689-53453689 G>A	1.0	4189	MELANOMA	-	-	-	-	ZNF816	ENST00000357666,p.H447Y|uc002qal.2,p.H447Y|NM_001202456,p.H447Y|NM_001202457,p.H447Y|NM_001031665,p.H447Y|uc021uzc.1,p.H447Y|uc002qam.2,p.H447Y|ENST00000444460,p.H447Y	protein_coding	uc021uzc.1	nonsynonymous SNV	exon4	c.C1339T	p.H447Y	RSDSYLAEHQRVHTGEKPYKCNKCG	RSDSYLAEHQRVYTGEKPYKCNKCG	7.0	6.0	-	-	4189_19:53453689-53453689 G>A_RSDSYLAEHQRVYTGEKPYKCNKCG	0.0
18:72343813-72343813 T>G	0.0	4335	COLORECTAL	-	-	-	-	ZNF407	NM_001146190,p.F280V|NM_017757,p.F280V|uc010dqu.2,p.F280V|uc002llu.2,p.F279V|ENST00000309902,p.F280V|ENST00000582337,p.F280V|NM_001146189,p.F280V|ENST00000299687,p.F280V|ENST00000577538,p.F280V|uc010xfc.2,p.F280V|uc002llw.2,p.F280V	retained_intron, protein_coding, processed_transcript	uc010xfc.2	nonsynonymous SNV	exon1	c.T838G	p.F280V	HLRRQNLAARGGFVQILTKQPFPKK	HLRRQNLAARGGVVQILTKQPFPKK	6.0	7.0	-	-	4335_18:72343813-72343813 T>G_HLRRQNLAARGGVVQILTKQPFPKK	0.0
22:30403275-30403275 C>T	1.0	3466	MELANOMA	-	-	-	-	MTMR3	ENST00000351488,p.P282S|NM_153050,p.P282S|ENST00000401950,p.P282S|uc003agw.4,p.P282S|uc003agu.4,p.P282S|NM_021090,p.P282S|ENST00000333027,p.P282S|uc003agv.4,p.P282S|NM_153051,p.P282S|ENST00000406629,p.P282S|ENST00000323630,p.P146S	retained_intron, protein_coding, processed_transcript	uc003agw.4	nonsynonymous SNV	exon10	c.C844T	p.P282S	SKLSTRNTSRDFPNGGDLSDVEFDS	SKLSTRNTSRDFSNGGDLSDVEFDS	9.0	8.0	-	-	3466_22:30403275-30403275 C>T_SKLSTRNTSRDFSNGGDLSDVEFDS	0.0
12:53205701-53205701 G>T	1.0	4329	COLORECTAL	-	-	-	-	KRT4	ENST00000458244,p.Q155K|ENST00000293774,p.Q249K|uc031qhk.1,p.Q175K|ENST00000551956,p.Q175K|NM_002272,p.Q175K	retained_intron, protein_coding, nonsense_mediated_decay	uc031qhk.1	nonsynonymous SNV	exon2	c.C523A	p.Q175K	KVLETKWNLLQQQTTTTSSKNLEPL	KVLETKWNLLQQKTTTTSSKNLEPL	4.0	2.0	-	-	4329_12:53205701-53205701 G>T_KVLETKWNLLQQKTTTTSSKNLEPL	0.0
X:47039371-47039371 C>T	0.0	4287	COLORECTAL	-	-	-	1	RBM10	NM_001204468,p.R397C|uc010nhq.3,p.R255C|NM_152856,p.R255C|NM_005676,p.R332C|NM_001204467,p.R332C|NM_001204466,p.R255C|ENST00000377604,p.R332C|ENST00000345781,p.R255C|ENST00000329236,p.R255C|uc004dhf.3,p.R332C|uc004dhi.3,p.R397C|uc004dhg.3,p.R255C|uc004dhh.3,p.R332C	protein_coding, processed_transcript	uc010nhq.3	nonsynonymous SNV	exon9	c.C763T	p.R255C	LAPYAVLSSSNVRVIKDKQTQLNRG	LAPYAVLSSSNVCVIKDKQTQLNRG	9.0	9.0	-	-	4287_X:47039371-47039371 C>T_LAPYAVLSSSNVCVIKDKQTQLNRG	0.0
1:100361905-100361905 G>A	1.0	3713	MELANOMA	-	-	-	-	AGL	NM_000642,p.R1108K|ENST00000370165,p.R1108K|uc001dsl.1,p.R1108K|uc001dsi.1,p.R1108K|ENST00000361915,p.R1108K|NM_000646,p.R1092K|NM_000028,p.R1108K|ENST00000361522,p.R1091K|uc001dsm.1,p.R1092K|ENST00000361302,p.R1092K|NM_000644,p.R1108K|ENST00000370163,p.R1108K|uc001dsn.1,p.R1091K|uc001dsj.1,p.R1108K|ENST00000370161,p.R1092K|uc001dsk.1,p.R1108K|ENST00000294724,p.R1108K|NM_000645,p.R1091K|NM_000643,p.R1108K	protein_coding, processed_transcript	uc001dsn.1	nonsynonymous SNV	exon23	c.G3272A	p.R1091K	FRCWGRDTFIALRGILLITGRYVEA	FRCWGRDTFIALKGILLITGRYVEA	4.0	10.0	-	-	3713_1:100361905-100361905 G>A_FRCWGRDTFIALKGILLITGRYVEA	0.0
1:156640696-156640696 G>A	1.0	4244	COLORECTAL	-	-	ID=COSM1295244;OCCURENCE=1(urinary_tract)	-	NES	ENST00000368223,p.A1095V|uc001fpq.3,p.A1095V|NM_006617,p.A1095V|uc021pbh.1,p.A13V	protein_coding	uc021pbh.1	nonsynonymous SNV	exon1	c.C38T	p.A13V	MLGSEPAMGESAAGAEPGPGQGVGG	MLGSEPAMGESAVGAEPGPGQGVGG	9.0	10.0	-	-	4244_1:156640696-156640696 G>A_MLGSEPAMGESAVGAEPGPGQGVGG	0.0
21:44524456-44524456 G>A	1.0	4234	NSCLC	-	-	ID=COSM166866,COSM1142948;OCCURENCE=3(urinary_tract),3(liver),4(pancreas),3(endometrium),14(lung),36(haematopoietic_and_lymphoid_tissue),1(stomach)	1	U2AF1	uc002zda.1,p.S34F|ENST00000291552,p.S34F|NM_001025203,p.S34F|uc010gpi.1,p.S34F|ENST00000464750,p.S34F|uc002zdc.1,p.S34F|uc002zdb.1,p.S34F|NM_006758,p.S34F|ENST00000380276,p.S34F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010gpi.1	nonsynonymous SNV	exon2	c.C101T	p.S34F	FKIGACRHGDRCSRLHNKPTFSQTI	FKIGACRHGDRCFRLHNKPTFSQTI	9.0	3.0	CD8	-	4234_21:44524456-44524456 G>A_FKIGACRHGDRCFRLHNKPTFSQTI	1.0
4:54179867-54179867 C>A	1.0	4160	COLORECTAL	-	-	-	-	SCFD2	ENST00000401642,p.M357I|uc010igm.3,p.M357I|NM_152540,p.M357I|ENST00000388940,p.M357I|uc003gzu.3,p.M357I	protein_coding	uc010igm.3	nonsynonymous SNV	exon3	c.G1071T	p.M357I	EALLNTKHKEAVMEVRRHLVEAASR	EALLNTKHKEAVIEVRRHLVEAASR	6.0	9.0	-	-	4160_4:54179867-54179867 C>A_EALLNTKHKEAVIEVRRHLVEAASR	0.0
2:182766544-182766544 C>G	1.0	3775	CERVICAL	-	-	-	-	SSFA2	ENST00000409001,p.S255C|NM_001287504,p.S102C|NM_006751,p.S255C|ENST00000320370,p.S255C|uc002uoh.3,p.S255C|uc002uoi.3,p.S255C|NM_001287503,p.S255C|ENST00000428267,p.S102C|ENST00000431877,p.S255C|uc002uol.3,p.S102C|uc002uoj.3,p.S255C|NM_001130445,p.S255C|uc010zfo.2,p.S102C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zfo.2	nonsynonymous SNV	exon7	c.C305G	p.S102C	IEVLTTVANAFSSLYSQVSGTPLQR	IEVLTTVANAFSCLYSQVSGTPLQR	9.0	8.0	-	-	3775_2:182766544-182766544 C>G_IEVLTTVANAFSCLYSQVSGTPLQR	0.0
1:232942770-232942770 A>C	0.0	4238	COLORECTAL	-	-	-	-	MAP10	uc001hvh.2,p.R667S|NM_019090,p.R667S|ENST00000418460,p.R667S	protein_coding	uc001hvh.2	nonsynonymous SNV	exon1	c.A2001C	p.R667S	DMLVVHEKRELYRKRQSQMLGTKFR	DMLVVHEKRELYSKRQSQMLGTKFR	3.0	4.0	-	-	4238_1:232942770-232942770 A>C_DMLVVHEKRELYSKRQSQMLGTKFR	0.0
4:183713545-183713545 C>T	0.0	3919	MELANOMA	-	-	-	-	TENM3	ENST00000511685,p.S1907F|NM_001080477,p.S1907F|ENST00000406950,p.S1907F|uc003ivd.1,p.S1907F	retained_intron, protein_coding, processed_transcript	uc003ivd.1	nonsynonymous SNV	exon25	c.C5720T	p.S1907F	PSVARHTMQTIRSIGYYRNIYNPPE	PSVARHTMQTIRFIGYYRNIYNPPE	1.0	10.0	-	-	3919_4:183713545-183713545 C>T_PSVARHTMQTIRFIGYYRNIYNPPE	0.0
1:114523784-114523784 T>A	1.0	3919	MELANOMA	-	-	-	-	OLFML3	NM_020190,p.F205Y|ENST00000320334,p.F205Y|NM_001286353,p.F144Y|uc001ees.1,p.F185Y|NM_001286352,p.F185Y|ENST00000369551,p.F185Y|uc001eer.1,p.F205Y|uc001eet.1,p.F61Y|ENST00000393300,p.F185Y	protein_coding, processed_transcript	uc001eet.1	nonsynonymous SNV	exon2	c.T182A	p.F61Y	MAARKASRVRVPFPWVGTGQLVYGG	MAARKASRVRVPYPWVGTGQLVYGG	4.0	6.0	-	-	3919_1:114523784-114523784 T>A_MAARKASRVRVPYPWVGTGQLVYGG	0.0
19:44512958-44512958 A>G	0.0	4320	COLORECTAL	-	-	-	-	ZNF230	ENST00000429154,p.K11R|uc002oyb.1,p.K11R|ENST00000585568,p.K11R|ENST00000585632,p.K11R|NM_006300,p.K11R|ENST00000585491,p.K11R	retained_intron, protein_coding, nonsense_mediated_decay	uc002oyb.1	nonsynonymous SNV	exon3	c.A32G	p.K11R	MTTFKEAVTFKDVAVFFTEEELG	MTTFKEAVTFRDVAVFFTEEELG	6.0	5.0	-	-	4320_19:44512958-44512958 A>G_MTTFKEAVTFRDVAVFFTEEELG	0.0
15:80253423-80253423 T>G	0.0	4278	COLORECTAL	-	-	-	-	BCL2A1	ENST00000267953,p.K172Q|uc002bfc.4,p.K172Q|NM_004049,p.K172Q	protein_coding	uc002bfc.4	nonsynonymous SNV	exon2	c.A514C	p.K172Q	VTGKICEMLSLLKQYC	VTGKICEMLSLLQQYC	8.0	4.0	-	-	4278_15:80253423-80253423 T>G_VTGKICEMLSLLQQYC	0.0
4:48027240-48027240 C>T	1.0	4213	COLORECTAL	-	-	-	-	NIPAL1	uc003gxw.3,p.L68F|NM_207330,p.L68F|ENST00000511123,p.L33F|ENST00000511852,p.L68F|ENST00000295461,p.L68F	protein_coding, processed_transcript, nonsense_mediated_decay	uc003gxw.3	nonsynonymous SNV	exon2	c.C202T	p.L68F	LSISANVENKYSLYVGLVLAVSSSI	LSISANVENKYSFYVGLVLAVSSSI	6.0	3.0	-	-	4213_4:48027240-48027240 C>T_LSISANVENKYSFYVGLVLAVSSSI	0.0
2:130897790-130897790 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM1247549;OCCURENCE=1(oesophagus),1(large_intestine)	-	CCDC74B	ENST00000392984,p.R382C|uc010yzw.2,p.R382C|uc002tqn.2,p.R214C|NM_207310,p.R280C|ENST00000409943,p.R214C|uc002tqm.2,p.R280C|NM_001258307,p.R214C|ENST00000310463,p.R280C	retained_intron, protein_coding, nonsense_mediated_decay	uc010yzw.2	nonsynonymous SNV	exon4	c.C1144T	p.R382C	KPTTLRQCEVLIRELWNTNLLQTQE	KPTTLRQCEVLICELWNTNLLQTQE	5.0	1.0	-	-	4284_2:130897790-130897790 G>A_KPTTLRQCEVLICELWNTNLLQTQE	0.0
12:58186781-58186781 T>C	1.0	4180	BREAST	-	-	-	-	TSFM	NM_001172696,p.S187P|ENST00000323833,p.S187P|uc001sqh.3,p.S187P	protein_coding, processed_transcript, nonsense_mediated_decay	uc001sqh.3	nonsynonymous SNV	exon6	c.T559C	p.S187P	AEAGGSLEGFLNSSELSGLPAGPDR	AEAGGSLEGFLNPSELSGLPAGPDR	10.0	9.0	-	-	4180_12:58186781-58186781 T>C_AEAGGSLEGFLNPSELSGLPAGPDR	0.0
16:77398264-77398264 G>A	0.0	3998	MELANOMA	-	-	-	-	ADAMTS18	uc002ffc.4,p.P265S|ENST00000282849,p.P265S|NM_199355,p.P265S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ffc.4	nonsynonymous SNV	exon5	c.C793T	p.P265S	FCGRRKKYAPKPPTEDTYLRFDEYG	FCGRRKKYAPKPSTEDTYLRFDEYG	1.0	9.0	-	-	3998_16:77398264-77398264 G>A_FCGRRKKYAPKPSTEDTYLRFDEYG	0.0
1:40098352-40098352 G>C	1.0	4189	MELANOMA	-	-	-	-	HEYL	uc001cdp.3,p.S39W|NM_014571,p.S39W	protein_coding	uc001cdp.3	nonsynonymous SNV	exon2	c.C116G	p.S39W	SQMARPLSTPSSSQMQARKKRRGII	SQMARPLSTPSSWQMQARKKRRGII	5.0	8.0	-	-	4189_1:40098352-40098352 G>C_SQMARPLSTPSSWQMQARKKRRGII	0.0
14:55462368-55462368 C>T	0.0	4158	COLORECTAL	-	-	-	-	WDHD1	ENST00000360586,p.R369H|ENST00000420358,p.R246H|uc001xbn.2,p.R246H|NM_001008396,p.R246H|ENST00000421192,p.R246H|NM_007086,p.R369H|uc001xbm.2,p.R369H	retained_intron, protein_coding, nonsense_mediated_decay	uc001xbn.2	nonsynonymous SNV	exon10	c.G737A	p.R246H	DEDDEDLMMASGRPRQRSHILEDDE	DEDDEDLMMASGHPRQRSHILEDDE	6.0	8.0	-	-	4158_14:55462368-55462368 C>T_DEDDEDLMMASGHPRQRSHILEDDE	0.0
19:10226649-10226649 G>A	1.0	4252	COLORECTAL	-	-	-	-	EIF3G	ENST00000593054,p.R44C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000593054	nonsynonymous SNV	exon2	c.C130T	p.R44C	GASRRGESMQPNRREDTRETDLQEL	GASRRGESMQPNCREDTRETDLQEL	10.0	3.0	-	-	4252_19:10226649-10226649 G>A_GASRRGESMQPNCREDTRETDLQEL	0.0
12:25398284-25398284 C>T	0.0	4238	COLORECTAL	-	-	ID=COSM521,COSM1135366;OCCURENCE=1(salivary_gland),171(endometrium),265(ovary),20(soft_tissue),19(urinary_tract),1(kidney),2323(pancreas),15(liver),3(eye),22(prostate),321(biliary_tract),6237(large_intestine),18(breast),24(skin),58(small_intestine),25(upper_aerodigestive_tract),10(oesophagus),4(central_nervous_system),93(stomach),2(testis),19(cervix),114(haematopoietic_and_lymphoid_tissue),15(gastrointestinal_tract_(site_indeterminate)),37(thyroid),737(lung),25(peritoneum)	1	KRAS	ENST00000311936,p.G12D|NM_004985,p.G12D|ENST00000556131,p.G12D|ENST00000557334,p.G12D|NM_033360,p.G12D|uc001rgq.1,p.G12D|ENST00000256078,p.G12D|uc001rgp.1,p.G12D	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35A	p.G12D	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGADGVGKSALTIQLI	5.0	9.0	-	-	4238_12:25398284-25398284 C>T_MTEYKLVVVGADGVGKSALTIQLI	0.0
3:3214554-3214554 G>C	1.0	4278	COLORECTAL	-	-	-	-	CRBN	uc003bpq.3,p.R145G|ENST00000432408,p.R144G|uc011aso.2,p.R82G|NM_016302,p.R145G|ENST00000231948,p.R145G|uc003bpr.3,p.R144G|NM_001173482,p.R144G	retained_intron, protein_coding	uc011aso.2	nonsynonymous SNV	exon3	c.C244G	p.R82G	AQFGTTAEIYAYREEQDFGIEIVKV	AQFGTTAEIYAYGEEQDFGIEIVKV	10.0	5.0	-	-	4278_3:3214554-3214554 G>C_AQFGTTAEIYAYGEEQDFGIEIVKV	0.0
7:27237903-27237903 G>T	0.0	4326	BREAST	-	-	-	1	HOXA13	ENST00000222753,p.L361I|uc003szb.1,p.L361I|NM_000522,p.L361I	protein_coding, processed_transcript	uc003szb.1	nonsynonymous SNV	exon2	c.C1081A	p.L361I	KDKRRRISATTNLSERQVTIWFQNR	KDKRRRISATTNISERQVTIWFQNR	1.0	6.0	-	-	4326_7:27237903-27237903 G>T_KDKRRRISATTNISERQVTIWFQNR	0.0
15:42173432-42173432 C>T	0.0	4189	MELANOMA	-	-	-	-	SPTBN5	ENST00000320955,p.V820M|uc001zos.4,p.V820M|NM_016642,p.V820M	retained_intron, protein_coding	uc001zos.4	nonsynonymous SNV	exon13	c.G2458A	p.V820M	GRAASARASLFTVNSALSPPGESLR	GRAASARASLFTMNSALSPPGESLR	3.0	2.0	-	-	4189_15:42173432-42173432 C>T_GRAASARASLFTMNSALSPPGESLR	0.0
4:145039891-145039891 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GYPA	uc003ijn.2,p.L83I	retained_intron, protein_coding, nonsense_mediated_decay	uc003ijn.2	nonsynonymous SNV	exon4	c.C247A	p.L83I	YPPEEETGERVQLAHHFSEPAPVVI	YPPEEETGERVQIAHHFSEPAPVVI	1.0	9.0	-	-	4258_4:145039891-145039891 G>T_YPPEEETGERVQIAHHFSEPAPVVI	0.0
17:34144723-34144723 C>T	1.0	4180	BREAST	-	-	-	1	TAF15	uc002hkc.4,p.S4F|ENST00000587272,p.S4F|NM_139215,p.S4F|uc002hkd.4,p.S4F|ENST00000588240,p.S4F|ENST00000311979,p.S4F|NM_003487,p.S4F|ENST00000590273,p.S4F	retained_intron, protein_coding, nonsense_mediated_decay	uc002hkd.4	nonsynonymous SNV	exon2	c.C11T	p.S4F	MSDSGSYGQSGGEQQS	MSDFGSYGQSGGEQQS	9.0	10.0	-	-	4180_17:34144723-34144723 C>T_MSDFGSYGQSGGEQQS	0.0
17:7577538-7577538 C>T	1.0	4238	COLORECTAL	-	-	ID=COSM99021,COSM99020,COSM10662,COSM99602,COSM3356964,COSM1640830;OCCURENCE=37(urinary_tract),1(adrenal_gland),2(kidney),17(pancreas),8(liver),5(prostate),154(large_intestine),4(biliary_tract),72(breast),13(skin),7(small_intestine),12(endometrium),1(pituitary),32(ovary),3(cervix),58(haematopoietic_and_lymphoid_tissue),1(pleura),5(thyroid),1(peritoneum),18(lung),37(upper_aerodigestive_tract),2(NS),4(bone),3(vulva),37(oesophagus),45(central_nervous_system),37(stomach)	1	TP53	ENST00000413465,p.R248Q|NM_001126115,p.R116Q|uc010cnf.2,p.R89Q|NM_001126113,p.R248Q|NM_001276760,p.R209Q|NM_001126116,p.R116Q|uc002gij.3,p.R209Q|uc002gii.2,p.R89Q|uc002gig.1,p.R248Q|ENST00000359597,p.R248Q|NM_001276699,p.R89Q|uc002gin.3,p.R155Q|NM_001276696,p.R209Q|NM_001126118,p.R209Q|NM_001126114,p.R248Q|ENST00000455263,p.R248Q|NM_001126112,p.R248Q|ENST00000509690,p.R116Q|NM_000546,p.R248Q|uc010cng.2,p.R89Q|ENST00000445888,p.R248Q|NM_001276698,p.R89Q|uc002gio.3,p.R116Q|NM_001276761,p.R209Q|ENST00000269305,p.R248Q|NM_001276697,p.R89Q|uc002gih.3,p.R248Q|NM_001126117,p.R116Q|NM_001276695,p.R209Q|ENST00000420246,p.R248Q|uc031qyq.1,p.R209Q	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon6	c.G626A	p.R209Q	YMCNSSCMGGMNRRPILTIITLEDS	YMCNSSCMGGMNQRPILTIITLEDS	10.0	10.0	-	-	4238_17:7577538-7577538 C>T_YMCNSSCMGGMNQRPILTIITLEDS	0.0
19:4508878-4508878 A>C	0.0	4245	COLORECTAL	-	-	-	-	PLIN4	ENST00000301286,p.F1188V|uc010dub.1,p.F212V|uc002mar.1,p.F1188V|NM_001080400,p.F1188V	protein_coding	uc010dub.1	nonsynonymous SNV	exon3	c.T634G	p.F212V	SYFVRLGDLGPSFRQRAFEHAVSHL	SYFVRLGDLGPSVRQRAFEHAVSHL	2.0	5.0	-	-	4245_19:4508878-4508878 A>C_SYFVRLGDLGPSVRQRAFEHAVSHL	0.0
X:15845471-15845471 G>A	1.0	4000	MELANOMA	-	-	-	-	AP1S2	ENST00000329235,p.L151F|NM_003916,p.L151F|uc004cxi.4,p.L151F	protein_coding, processed_transcript	uc004cxi.4	nonsynonymous SNV	exon5	c.C451T	p.L151F	LLQEEAETPRSVLEEIGLT	LLQEEAETPRSVFEEIGLT	10.0	10.0	-	-	4000_X:15845471-15845471 G>A_LLQEEAETPRSVFEEIGLT	0.0
10:99211955-99211955 C>T	1.0	4046	OVARIAN	-	-	-	-	ZDHHC16	ENST00000370842,p.H118Y|uc001knk.3,p.H118Y|NM_001287803,p.H118Y|NM_001287804,p.H118Y|uc001knj.3,p.H118Y|ENST00000352634,p.H118Y|uc001knn.3,p.H118Y|ENST00000414567,p.H118Y|ENST00000370854,p.H118Y|ENST00000370846,p.H118Y|uc010qow.2,p.H118Y|NM_198046,p.H118Y|NM_198044,p.H118Y|ENST00000353979,p.H118Y|NM_198043,p.H118Y|NM_032327,p.H118Y|uc001knl.3,p.H118Y|ENST00000393760,p.H118Y	protein_coding, processed_transcript	uc010qow.2	nonsynonymous SNV	exon4	c.C352T	p.H118Y	ILRTYSVPRLCWHFFYSHWNLILIV	ILRTYSVPRLCWYFFYSHWNLILIV	10.0	9.0	-	-	4046_10:99211955-99211955 C>T_ILRTYSVPRLCWYFFYSHWNLILIV	0.0
19:15375416-15375416 G>T	1.0	4252	COLORECTAL	-	-	-	1	BRD4	ENST00000371835,p.D337E|uc002nar.3,p.D337E|ENST00000263377,p.D337E|ENST00000360016,p.D337E|uc002nat.3,p.D337E|uc002nas.3,p.D337E|NM_058243,p.D337E|ENST00000594841,p.D337E|NM_014299,p.D337E|uc002nau.4,p.D337E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002nau.4	nonsynonymous SNV	exon6	c.C1011A	p.D337E	SRPVKPPKKDVPDSQQHPAPEKSSK	SRPVKPPKKDVPESQQHPAPEKSSK	9.0	6.0	-	-	4252_19:15375416-15375416 G>T_SRPVKPPKKDVPESQQHPAPEKSSK	0.0
X:140983304-140983304 G>A	0.0	4240	BREAST	-	-	ID=COSM1490561;OCCURENCE=1(breast)	-	MAGEC3	uc011mwp.2,p.R361Q|ENST00000298296,p.R361Q|NM_138702,p.R361Q	protein_coding, processed_transcript	uc011mwp.2	nonsynonymous SNV	exon6	c.G1082A	p.R361Q	QGLAGHRQEDGRRGLTEASPQQKKG	QGLAGHRQEDGRQGLTEASPQQKKG	3.0	9.0	-	-	4240_X:140983304-140983304 G>A_QGLAGHRQEDGRQGLTEASPQQKKG	0.0
19:47258744-47258744 G>A	1.0	4317	COLORECTAL	-	-	-	-	FKRP	ENST00000600629,p.A13T|NM_024301,p.A13T|ENST00000597313,p.A13T|ENST00000593902,p.A13T|ENST00000600005,p.A13T|uc002pfn.2,p.A13T|ENST00000601299,p.A13T|NM_001039885,p.A13T|ENST00000600227,p.A13T|uc002pfp.2,p.A13T|ENST00000602250,p.A13T|ENST00000596460,p.A13T|ENST00000595868,p.A13T|ENST00000598271,p.A13T|ENST00000391909,p.A13T|ENST00000318584,p.A13T|ENST00000600834,p.A13T|ENST00000593800,p.A13T|ENST00000593875,p.A13T|uc021uwj.1,p.A13T|ENST00000602181,p.A13T|ENST00000595570,p.A13T	retained_intron, protein_coding, processed_transcript	uc021uwj.1	nonsynonymous SNV	exon1	c.G37A	p.A13T	MRLTRCQAALAAAITLNLLVLFYVS	MRLTRCQAALAATITLNLLVLFYVS	6.0	7.0	-	-	4317_19:47258744-47258744 G>A_MRLTRCQAALAATITLNLLVLFYVS	0.0
11:46726649-46726649 C>T	1.0	3466	MELANOMA	-	-	-	-	ZNF408	uc010rgw.2,p.P459S|NM_024741,p.P467S|uc001nde.2,p.P467S|NM_001184751,p.P459S|ENST00000311764,p.P467S	retained_intron, protein_coding	uc010rgw.2	nonsynonymous SNV	exon5	c.C1375T	p.P459S	HRKTHQVPAAPAPCPCPVCGRPLAN	HRKTHQVPAAPASCPCPVCGRPLAN	4.0	7.0	-	-	3466_11:46726649-46726649 C>T_HRKTHQVPAAPASCPCPVCGRPLAN	0.0
12:25054798-25054798 C>T	0.0	4235	COLORECTAL	-	-	-	-	BCAT1	uc001rgd.4,p.A10T|NM_001178091,p.A10T|ENST00000539780,p.A10T|uc010siy.2,p.A10T|ENST00000261192,p.A10T|NM_005504,p.A10T	protein_coding, processed_transcript	uc010siy.2	nonsynonymous SNV	exon2	c.G28A	p.A10T	MKDCSNGCSAECTGEGGSKEVV	MKDCSNGCSTECTGEGGSKEVV	5.0	8.0	-	-	4235_12:25054798-25054798 C>T_MKDCSNGCSTECTGEGGSKEVV	0.0
2:80874951-80874951 C>T	0.0	3903	MELANOMA	-	-	ID=COSM1023230,COSM1023231;OCCURENCE=1(endometrium)	2	CTNNA2	NM_001282598,p.S925L|uc010ysh.2,p.S939L|NM_004389,p.S891L|NM_001282599,p.S570L|ENST00000540488,p.S846L|ENST00000496558,p.S891L|uc010ysj.2,p.S220L|ENST00000402739,p.S939L|ENST00000343114,p.S570L|NM_001282600,p.S523L|NM_001282597,p.S939L|uc010ysi.2,p.S523L|uc010yse.2,p.S891L|NM_001164883,p.S846L|ENST00000466387,p.S891L|uc010ysf.2,p.S891L|uc010ysg.2,p.S846L|ENST00000541047,p.S891L|ENST00000361291,p.S925L	retained_intron, protein_coding, processed_transcript	uc010ysj.2	nonsynonymous SNV	exon4	c.C659T	p.S220L	TRVRRGSQKKHISPVQALSEFKAMD	TRVRRGSQKKHILPVQALSEFKAMD	2.0	2.0	-	-	3903_2:80874951-80874951 C>T_TRVRRGSQKKHILPVQALSEFKAMD	0.0
2:183050718-183050718 C>A	0.0	4316	COLORECTAL	-	-	-	-	PDE1A	ENST00000410103,p.D489Y|uc010zfp.2,p.D385Y|uc010zfq.2,p.D493Y|ENST00000358139,p.D489Y|NM_001258314,p.D455Y|NM_001258313,p.D473Y|ENST00000456212,p.D489Y|uc002uoq.2,p.D489Y|ENST00000435564,p.D489Y|uc002uou.4,p.D455Y|ENST00000351439,p.D473Y|NM_005019,p.D489Y|NM_001003683,p.D489Y|uc002uos.4,p.D489Y|ENST00000409365,p.D473Y|uc002uor.4,p.D473Y|ENST00000346717,p.D455Y|ENST00000331935,p.D489Y|NM_001258312,p.D493Y|ENST00000536095,p.D385Y	protein_coding, processed_transcript	uc010zfq.2	nonsynonymous SNV	exon14	c.G1477T	p.D493Y	TKGSMSDGSYSPDYSLAAVDLKSFK	TKGSMSDGSYSPYYSLAAVDLKSFK	2.0	6.0	-	-	4316_2:183050718-183050718 C>A_TKGSMSDGSYSPYYSLAAVDLKSFK	0.0
15:66737003-66737003 G>A	1.0	2591	MELANOMA	-	-	-	1	MAP2K1	ENST00000307102,p.G176S|NM_002755,p.G176S|uc010ujp.2,p.G154S|uc010bhq.3,p.G176S	retained_intron, protein_coding	uc010ujp.2	nonsynonymous SNV	exon5	c.G460A	p.G154S	QILGKVSIAVIKGLTYLREKHKIMH	QILGKVSIAVIKSLTYLREKHKIMH	10.0	8.0	-	-	2591_15:66737003-66737003 G>A_QILGKVSIAVIKSLTYLREKHKIMH	0.0
2:182926190-182926190 C>T	0.0	4298	COLORECTAL	-	-	-	-	PPP1R1C	NM_001261424,p.P62L|ENST00000452904,p.P55L|NM_001261425,p.P55L|NM_001080545,p.P55L|ENST00000409702,p.P55L|ENST00000409137,p.P55L|uc002uop.2,p.P55L|uc002uoo.4,p.P55L|uc010frm.2,p.P62L|ENST00000280295,p.P62L	retained_intron, protein_coding, processed_transcript	uc010frm.2	nonsynonymous SNV	exon3	c.C185T	p.P62L	EHNPPEIDDKRGPNTQGELQNASPK	EHNPPEIDDKRGLNTQGELQNASPK	4.0	6.0	-	-	4298_2:182926190-182926190 C>T_EHNPPEIDDKRGLNTQGELQNASPK	0.0
17:34641474-34641474 A>T	0.0	4238	COLORECTAL	-	-	-	-	CCL4L1,CCL4L2	NM_207007,p.Q72H|uc002hlw.3,p.Q72H|ENST00000394465,p.Q72H	retained_intron, protein_coding	uc002hlw.3	nonsynonymous SNV	exon3	c.A216T	p.Q72H	QPAVVFQTKRGKQVCADPSESWVQE	QPAVVFQTKRGKHVCADPSESWVQE	3.0	3.0	-	-	4238_17:34641474-34641474 A>T_QPAVVFQTKRGKHVCADPSESWVQE	0.0
5:171509466-171509466 C>T	0.0	4238	COLORECTAL	-	-	-	-	STK10	ENST00000176763,p.R618H|uc003mbo.1,p.R618H|NM_005990,p.R618H	retained_intron, protein_coding, processed_transcript	uc003mbo.1	nonsynonymous SNV	exon12	c.G1853A	p.R618H	KKFFDTELENLERQQKQQVEKMEQD	KKFFDTELENLEHQQKQQVEKMEQD	7.0	9.0	-	-	4238_5:171509466-171509466 C>T_KKFFDTELENLEHQQKQQVEKMEQD	0.0
9:134006156-134006156 G>A	1.0	4129	NSCLC	-	-	-	1	NUP214	ENST00000411637,p.C199Y|ENST00000451030,p.C199Y|uc004cag.3,p.C199Y|ENST00000359428,p.C199Y|NM_005085,p.C199Y|uc004caf.1,p.C199Y|uc004cah.3,p.C199Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004cah.3	nonsynonymous SNV	exon5	c.G596A	p.C199Y	ATLPSTVAVTSVCWSPKGKQLAVGK	ATLPSTVAVTSVYWSPKGKQLAVGK	9.0	10.0	CD8	-	4129_9:134006156-134006156 G>A_ATLPSTVAVTSVYWSPKGKQLAVGK	2.0
6:136268611-136268611 G>A	0.0	4081	COLORECTAL	-	-	ID=COSM276696;OCCURENCE=2(endometrium),1(large_intestine)	-	PDE7B	NM_018945,p.E11K|uc003qgp.3,p.E11K|ENST00000308191,p.E11K	protein_coding	uc003qgp.3	nonsynonymous SNV	exon2	c.G31A	p.E11K	MSCLMVERCGEILFENPDQNAKC	MSCLMVERCGKILFENPDQNAKC	3.0	3.0	-	-	4081_6:136268611-136268611 G>A_MSCLMVERCGKILFENPDQNAKC	0.0
5:128365384-128365384 G>A	0.0	4301	MELANOMA	-	-	-	-	SLC27A6	NM_014031,p.R556Q|NM_001017372,p.R556Q|ENST00000262462,p.R556Q|ENST00000506176,p.R556Q|uc003kuy.3,p.R556Q|uc003kuz.3,p.R556Q|ENST00000395266,p.R556Q	protein_coding	uc003kuz.3	nonsynonymous SNV	exon9	c.G1667A	p.R556Q	QVVTFLPAYACPRFLRIQEKMEATG	QVVTFLPAYACPQFLRIQEKMEATG	4.0	2.0	-	-	4301_5:128365384-128365384 G>A_QVVTFLPAYACPQFLRIQEKMEATG	0.0
3:52393974-52393974 A>G	0.0	3903	MELANOMA	-	-	-	-	DNAH1	uc011bef.2,p.M1484V|ENST00000420323,p.M1484V|NM_015512,p.M1484V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bef.2	nonsynonymous SNV	exon27	c.A4450G	p.M1484V	DLVALVRGKLSRMQRAVLSALIVIE	DLVALVRGKLSRVQRAVLSALIVIE	5.0	4.0	-	-	3903_3:52393974-52393974 A>G_DLVALVRGKLSRVQRAVLSALIVIE	0.0
9:21971178-21971179 CG>-, 9:21971181-21971181 C>A	1.0	1913	MELANOMA	-	-	-	1	CDKN2A	ENST00000530628,p.G74fs|NM_058195,p.G74fs|ENST00000579755,p.G74fs|uc003zpl.3,p.G74fs|ENST00000361570,p.G115fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zpl.3	frameshift deletion	exon2	c.222_223del	p.G74fs	RRPGHDDGQRPSGGAAAAPRRGAQL	RRPGHDDGQRPSGSCCCSTARSPTAPTPPLSPDPCTTLPGRASWTRWWCCTGPGRGWTCAMPGAVCPWTWLRSWATA	10.0	9.0	CD8	fs,snv,coded into 3'UTR PR	1913_9:21971178-21971179 CG>-, 9:21971181-21971181 C>A_RRPGHDDGQRPSGSCCCSTARSPTAPTPPLSPDPCTTLPGRASWTRWWCCTGPGRGWTCAMPGAVCPWTWLRSWATA	1.0
7:98534799-98534799 T>C	1.0	3713	MELANOMA	-	-	-	1	TRRAP	ENST00000446306,p.Y1377H|uc003upr.3,p.Y1070H|NM_001244580,p.Y1378H|ENST00000355540,p.Y1378H|uc003upp.3,p.Y1378H|uc011kis.2,p.Y1378H|ENST00000359863,p.Y1378H|NM_003496,p.Y1378H	retained_intron, protein_coding	uc011kis.2	nonsynonymous SNV	exon29	c.T4132C	p.Y1378H	RIAALNALAACNYLPQSREKIIAAL	RIAALNALAACNHLPQSREKIIAAL	5.0	8.0	-	-	3713_7:98534799-98534799 T>C_RIAALNALAACNHLPQSREKIIAAL	0.0
2:203831758-203831758 ->A	0.0	4081	COLORECTAL	-	-	-	-	CARF	ENST00000402905,p.L297fs|ENST00000438828,p.L297fs|uc002uzp.2,p.L297fs|NM_001104586,p.L297fs|ENST00000414439,p.L195fs|ENST00000422368,p.L267fs|ENST00000545253,p.L209fs|NM_024744,p.L297fs|uc010zic.1,p.L209fs|uc002uzo.2,p.L297fs|ENST00000428585,p.L221fs|NM_001282910,p.L221fs|NM_001282911,p.L221fs|ENST00000545262,p.L221fs|NM_001282912,p.L209fs|ENST00000320443,p.L297fs|uc010zib.1,p.L221fs|uc010zia.1,p.L221fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zic.1	frameshift insertion	exon7	c.627dupA	p.L209fs	ECQYGPRRKGFQLKKVSEQESRSCQ	ECQYGPRRKGFQLKKSQ	4.0	8.0	-	-	4081_2:203831758-203831758 ->A_ECQYGPRRKGFQLKKSQ	0.0
9:35802530-35802530 C>T	1.0	4000	MELANOMA	-	-	-	-	NPR2	uc010mlb.3,p.R581C|ENST00000342694,p.R581C|NM_003995,p.R581C|uc003zyd.3,p.R581C	retained_intron, protein_coding, nonsense_mediated_decay	uc010mlb.3	nonsynonymous SNV	exon11	c.C1741T	p.R581C	KHMRDVQFNHLTRFIGACIDPPNIC	KHMRDVQFNHLTCFIGACIDPPNIC	6.0	1.0	-	-	4000_9:35802530-35802530 C>T_KHMRDVQFNHLTCFIGACIDPPNIC	0.0
1:32265636-32265636 G>A	0.0	3713	MELANOMA	-	-	-	-	SPOCD1	ENST00000360482,p.S570L|ENST00000528791,p.S63L|uc001btv.3,p.S63L|ENST00000373648,p.S511L|uc001btu.3,p.S570L|ENST00000257100,p.S63L|ENST00000533231,p.S570L|NM_144569,p.S570L|uc001bts.1,p.S570L|NM_001281988,p.S63L|NM_001281987,p.S570L	retained_intron, protein_coding	uc001btv.3	nonsynonymous SNV	exon4	c.C188T	p.S63L	PRSGSLALGDPSSDPACSQSGPMEA	PRSGSLALGDPSLDPACSQSGPMEA	4.0	6.0	-	-	3713_1:32265636-32265636 G>A_PRSGSLALGDPSLDPACSQSGPMEA	0.0
7:97482421-97482421 G>A	1.0	4240	BREAST	-	-	-	-	ASNS	ENST00000444334,p.S455L|NM_133436,p.S476L|uc003uou.4,p.S476L|uc003uox.4,p.S393L|uc003uot.4,p.S476L|ENST00000455086,p.S393L|uc011kin.2,p.S393L|NM_001673,p.S476L|uc011kio.2,p.S455L|ENST00000437628,p.S393L|ENST00000422745,p.S455L|ENST00000394309,p.S476L|NM_001178077,p.S393L|ENST00000394308,p.S476L|ENST00000175506,p.S476L|NM_183356,p.S476L|NM_001178075,p.S455L|NM_001178076,p.S393L|uc003uov.4,p.S476L	retained_intron, protein_coding, nonsense_mediated_decay	uc011kio.2	nonsynonymous SNV	exon12	c.C1364T	p.S455L	WRPKEAFSDGITSVKNSWFKILQEY	WRPKEAFSDGITLVKNSWFKILQEY	8.0	9.0	-	-	4240_7:97482421-97482421 G>A_WRPKEAFSDGITLVKNSWFKILQEY	0.0
1:178414712-178414712 G>C	1.0	4240	BREAST	-	-	-	-	RASAL2	uc001glq.3,p.L514F|NM_170692,p.L514F|uc001glr.3,p.L366F|ENST00000448150,p.L496F|NM_004841,p.L366F|ENST00000367649,p.L514F|ENST00000462775,p.L366F	retained_intron, protein_coding, processed_transcript	uc001glr.3	nonsynonymous SNV	exon7	c.G1098C	p.L366F	MSEVDRCGEHDVLIFRENTIATKSI	MSEVDRCGEHDVFIFRENTIATKSI	7.0	10.0	-	-	4240_1:178414712-178414712 G>C_MSEVDRCGEHDVFIFRENTIATKSI	0.0
1:151751416-151751416 T>G	1.0	4071	COLORECTAL	-	-	-	-	TDRKH	ENST00000368823,p.T206P|ENST00000368822,p.T210P|ENST00000368824,p.T210P|uc001ezc.4,p.T165P|NM_001083965,p.T210P|ENST00000368827,p.T210P|uc001ezd.4,p.T210P|uc009wnb.1,p.T210P|uc001eza.4,p.T210P|ENST00000458431,p.T210P|ENST00000368825,p.T165P|NM_001083964,p.T165P|NM_001083963,p.T210P|uc001ezb.4,p.T206P|NM_006862,p.T210P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009wnb.1	nonsynonymous SNV	exon6	c.A628C	p.T210P	EELRKRIAHSAETRVPRKQPISVRR	EELRKRIAHSAEPRVPRKQPISVRR	5.0	9.0	-	-	4071_1:151751416-151751416 T>G_EELRKRIAHSAEPRVPRKQPISVRR	0.0
3:101483736-101483736 A>C	0.0	4345	COLORECTAL	-	-	-	-	CEP97	uc003dvm.1,p.S485R|NM_024548,p.S647R|ENST00000327230,p.S673R|uc003dvl.1,p.S369R|ENST00000341893,p.S647R|uc003dvk.1,p.S647R|uc011bhf.1,p.S588R|ENST00000494050,p.S588R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bhf.1	nonsynonymous SNV	exon11	c.A1762C	p.S588R	LQVWQQTVDQRLSSWHTDVPPISST	LQVWQQTVDQRLRSWHTDVPPISST	5.0	3.0	-	-	4345_3:101483736-101483736 A>C_LQVWQQTVDQRLRSWHTDVPPISST	0.0
17:6387556-6387556 C>T	0.0	2591	MELANOMA	-	-	-	-	PITPNM3	NM_031220,p.E111K|ENST00000421306,p.E75K|uc010cln.3,p.E75K|ENST00000262483,p.E111K|NM_001165966,p.E75K|uc002gdd.4,p.E111K	retained_intron, protein_coding, processed_transcript	uc010cln.3	nonsynonymous SNV	exon4	c.G223A	p.E75K	LRRQRFPAQGSIEIHEDSEEGCPQR	LRRQRFPAQGSIKIHEDSEEGCPQR	2.0	3.0	-	-	2591_17:6387556-6387556 C>T_LRRQRFPAQGSIKIHEDSEEGCPQR	0.0
X:49127168-49127168 G>A	0.0	4287	COLORECTAL	-	-	ID=COSM1122499;OCCURENCE=1(endometrium)	-	PPP1R3F	ENST00000055335,p.R279H|uc004dnh.2,p.R279H|NM_033215,p.R279H	protein_coding	uc004dnh.2	nonsynonymous SNV	exon1	c.G836A	p.R279H	TPEGTFWANNHGRNYTVLLRIAPAP	TPEGTFWANNHGHNYTVLLRIAPAP	4.0	7.0	-	-	4287_X:49127168-49127168 G>A_TPEGTFWANNHGHNYTVLLRIAPAP	0.0
16:57507635-57507635 C>T	1.0	4326	BREAST	-	-	-	-	DOK4	ENST00000566936,p.G251D|uc010cdb.3,p.G251D|uc002elv.4,p.G251D|ENST00000340099,p.G251D|ENST00000569548,p.G251D|NM_018110,p.G251D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cdb.3	nonsynonymous SNV	exon7	c.G752A	p.G251D	LEMEKNVRLLNKGTEHYSYPCTPTT	LEMEKNVRLLNKDTEHYSYPCTPTT	6.0	9.0	-	-	4326_16:57507635-57507635 C>T_LEMEKNVRLLNKDTEHYSYPCTPTT	0.0
14:51464776-51464776 G>A	0.0	4346	COLORECTAL	-	-	-	-	TRIM9	uc001wyy.2,p.T528M|ENST00000338969,p.T528M	retained_intron, protein_coding, processed_transcript	uc001wyy.2	nonsynonymous SNV	exon7	c.C1583T	p.T528M	GVSPYSKTLVLQTSEDTDSEEQTLP	GVSPYSKTLVLQMSEDTDSEEQTLP	3.0	1.0	-	-	4346_14:51464776-51464776 G>A_GVSPYSKTLVLQMSEDTDSEEQTLP	0.0
X:27840321-27840321 C>T	1.0	4196	COLORECTAL	-	-	-	-	MAGEB10	ENST00000356790,p.P300S|uc004dbw.3,p.P300S|NM_182506,p.P300S|uc022bud.1,p.P300S	protein_coding	uc022bud.1	nonsynonymous SNV	exon1	c.C898T	p.P300S	VLEFLAKVNDTAPSEFSNWYTEALQ	VLEFLAKVNDTASSEFSNWYTEALQ	4.0	9.0	-	-	4196_X:27840321-27840321 C>T_VLEFLAKVNDTASSEFSNWYTEALQ	0.0
9:140082339-140082339 G>A	1.0	3713	MELANOMA	-	-	-	-	ANAPC2	uc011mer.1,p.L112F|ENST00000323927,p.L112F|NM_013366,p.L112F|uc004clr.1,p.L112F	protein_coding, processed_transcript	uc011mer.1	nonsynonymous SNV	exon2	c.C334T	p.L112F	NSADEPQCLLLLLDAFGLLESRLDP	NSADEPQCLLLLFDAFGLLESRLDP	7.0	8.0	-	-	3713_9:140082339-140082339 G>A_NSADEPQCLLLLFDAFGLLESRLDP	0.0
19:3637436-3637436 G>A	0.0	4240	BREAST	-	-	-	-	PIP5K1C	ENST00000589578,p.S699L|NM_001300849,p.S699L|uc010xhr.2,p.S699L	protein_coding, processed_transcript	uc010xhr.2	nonsynonymous SNV	exon17	c.C2096T	p.S699L	AAGPRPEAQCLTSVVFQKGFG	AAGPRPEAQCLTLVVFQKGFG	8.0	10.0	-	-	4240_19:3637436-3637436 G>A_AAGPRPEAQCLTLVVFQKGFG	0.0
1:92647180-92647180 G>A	0.0	3795	MELANOMA	-	-	-	-	KIAA1107	uc001dop.3,p.D801N|NM_015237,p.D876N|ENST00000409154,p.D931N|uc010otd.2,p.D876N|ENST00000370378,p.D876N	protein_coding	uc010otd.2	nonsynonymous SNV	exon8	c.G2626A	p.D876N	SDTSTPEELKIYDSNLRIEVKMKKQ	SDTSTPEELKIYNSNLRIEVKMKKQ	4.0	8.0	-	-	3795_1:92647180-92647180 G>A_SDTSTPEELKIYNSNLRIEVKMKKQ	0.0
2:168105953-168105953 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	XIRP2	uc010fpq.3,p.T2462N|NM_152381,p.T2684N|ENST00000295237,p.T2684N|uc002udx.3,p.T2684N|ENST00000409273,p.T2462N|NM_001199144,p.T2462N|uc002udy.3,p.T2509N|ENST00000409195,p.T2684N	protein_coding	uc010fpq.3	nonsynonymous SNV	exon7	c.C7385A	p.T2462N	ACEIKQSHQECSTQQTQQKKYLEQL	ACEIKQSHQECSNQQTQQKKYLEQL	5.0	7.0	-	-	4258_2:168105953-168105953 C>A_ACEIKQSHQECSNQQTQQKKYLEQL	0.0
13:28494547-28494547 C>A	0.0	4316	COLORECTAL	-	-	-	-	PDX1	uc001urt.2,p.A91E|ENST00000381033,p.A91E|NM_000209,p.A91E	protein_coding	uc001urt.2	nonsynonymous SNV	exon1	c.C272A	p.A91E	VAHLHHHLPAQLALPHPPAGPFPEG	VAHLHHHLPAQLELPHPPAGPFPEG	3.0	3.0	-	-	4316_13:28494547-28494547 C>A_VAHLHHHLPAQLELPHPPAGPFPEG	0.0
6:33374045-33374045 C>T	1.0	4316	COLORECTAL	-	-	-	-	KIFC1	ENST00000428849,p.R537C|uc003oef.4,p.R537C|NM_002263,p.R537C|uc011drf.2,p.R529C	retained_intron, protein_coding, processed_transcript	uc011drf.2	nonsynonymous SNV	exon8	c.C1585T	p.R529C	AVARTAQNERSSRSHSVFQLQISGE	AVARTAQNERSSCSHSVFQLQISGE	8.0	7.0	-	-	4316_6:33374045-33374045 C>T_AVARTAQNERSSCSHSVFQLQISGE	0.0
16:3487308-3487308 C>T	1.0	4284	COLORECTAL	-	-	-	-	ZNF597	uc002cvd.3,p.E131K|NM_152457,p.E131K|ENST00000301744,p.E131K	protein_coding	uc002cvd.3	nonsynonymous SNV	exon4	c.G391A	p.E131K	LLVTIENHTPLVELSEYLGTNTLSE	LLVTIENHTPLVKLSEYLGTNTLSE	5.0	8.0	-	-	4284_16:3487308-3487308 C>T_LLVTIENHTPLVKLSEYLGTNTLSE	0.0
6:152697659-152697659 T>C	0.0	4335	COLORECTAL	-	-	-	-	SYNE1	NM_033071,p.K3068E|uc003qot.4,p.K3068E|ENST00000265368,p.K3061E|ENST00000367255,p.K3061E|ENST00000448038,p.K3068E|ENST00000423061,p.K3068E|NM_182961,p.K3061E|uc003qov.3,p.K139E|ENST00000341594,p.K3100E|uc003qou.4,p.K3061E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003qov.3	nonsynonymous SNV	exon3	c.A415G	p.K139E	CLCLQASKGCQNKEQILQQRFRKAF	CLCLQASKGCQNEEQILQQRFRKAF	9.0	1.0	-	-	4335_6:152697659-152697659 T>C_CLCLQASKGCQNEEQILQQRFRKAF	0.0
6:143092287-143092287 G>A	1.0	3713	MELANOMA	-	-	-	-	HIVEP2	ENST00000367604,p.P1197S|ENST00000012134,p.P1197S|NM_006734,p.P1197S|ENST00000367603,p.P1197S|uc003qjd.3,p.P1197S	protein_coding, processed_transcript	uc003qjd.3	nonsynonymous SNV	exon5	c.C3589T	p.P1197S	EQPHLFPHQETIPFSPIQNALFQFQ	EQPHLFPHQETISFSPIQNALFQFQ	6.0	2.0	-	-	3713_6:143092287-143092287 G>A_EQPHLFPHQETISFSPIQNALFQFQ	0.0
16:51173801-51173801 C>T	0.0	4298	COLORECTAL	-	-	-	-	SALL1	ENST00000570206,p.A681T|uc021tid.1,p.A681T|ENST00000251020,p.A778T|ENST00000440970,p.A681T|uc021tie.1,p.A778T|NM_001127892,p.A681T|uc021tif.1,p.A681T|NM_002968,p.A778T	protein_coding, processed_transcript	uc021tif.1	nonsynonymous SNV	exon2	c.G2041A	p.A681T	HSCPICQKKFTNAVVLQQHIRMHMG	HSCPICQKKFTNTVVLQQHIRMHMG	3.0	7.0	-	-	4298_16:51173801-51173801 C>T_HSCPICQKKFTNTVVLQQHIRMHMG	0.0
3:157920925-157920925 A>C	1.0	4298	COLORECTAL	-	-	-	-	RSRC1	ENST00000480119,p.T129P|ENST00000475278,p.T129P|NM_016625,p.T129P|ENST00000494002,p.T129P|ENST00000480820,p.T129P|uc003fbt.4,p.T129P|NM_001271838,p.T129P|ENST00000471994,p.T129P|ENST00000476899,p.T129P|ENST00000295930,p.T129P|uc003fbu.2,p.T129P	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fbu.2	nonsynonymous SNV	exon4	c.A385C	p.T129P	HSRSSERSSHRRTRSRSRDRERRKG	HSRSSERSSHRRPRSRSRDRERRKG	9.0	1.0	-	-	4298_3:157920925-157920925 A>C_HSRSSERSSHRRPRSRSRDRERRKG	0.0
7:140380908-140380908 C>T	1.0	3713	MELANOMA	-	-	-	-	ADCK2	ENST00000473512,p.R66W|uc003vvz.3,p.R426W|ENST00000476491,p.R426W|uc003vvy.1,p.R426W|ENST00000072869,p.R426W|NM_052853,p.R426W	retained_intron, protein_coding	uc003vvz.3	nonsynonymous SNV	exon4	c.C1276T	p.R426W	AGIPVDLKRKIARLGINMLLKMIFV	AGIPVDLKRKIAWLGINMLLKMIFV	7.0	8.0	-	-	3713_7:140380908-140380908 C>T_AGIPVDLKRKIAWLGINMLLKMIFV	0.0
4:177249464-177249464 A>T	1.0	2556	MELANOMA	-	-	-	-	SPCS3	uc003iur.4,p.I176L|NM_021928,p.I176L|ENST00000503362,p.I176L	retained_intron, protein_coding, processed_transcript	uc003iur.4	nonsynonymous SNV	exon5	c.A526T	p.I176L	GHVSVPFPDTYEITKSY	GHVSVPFPDTYELTKSY	10.0	3.0	-	-	2556_4:177249464-177249464 A>T_GHVSVPFPDTYELTKSY	0.0
8:41553957-41553957 G>A	0.0	4237	NSCLC	-	-	-	2	ANK1	ENST00000379758,p.P962S|uc003xoh.3,p.P278S|NM_020476,p.P962S|ENST00000347528,p.P962S|ENST00000352337,p.P962S|ENST00000289734,p.P962S|uc003xoi.3,p.P962S|NM_001142446,p.P1003S|uc003xol.3,p.P962S|ENST00000396942,p.P962S|uc003xoj.3,p.P962S|uc003xok.3,p.P962S|ENST00000396945,p.P962S|ENST00000265709,p.P1003S|uc003xom.3,p.P1003S|NM_020475,p.P962S|NM_020477,p.P962S|NM_000037,p.P962S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xom.3	nonsynonymous SNV	exon27	c.C3007T	p.P1003S	TCRLVKPQKLSTPPPLAEEEGLASR	TCRLVKPQKLSTSPPLAEEEGLASR	4.0	9.0	-	-	4237_8:41553957-41553957 G>A_TCRLVKPQKLSTSPPLAEEEGLASR	0.0
17:63530030-63530030 ->TA	1.0	4316	COLORECTAL	-	-	-	1	AXIN2	NM_004655,p.R802fs|ENST00000375702,p.R737fs|uc002jfh.3,p.R737fs|uc002jfi.3,p.R802fs|ENST00000307078,p.R802fs	retained_intron, protein_coding	uc002jfi.3	frameshift insertion	exon10	c.2404_2405insTA	p.R802fs	HFKEQLSKKGNYRYYFKKASDEFAC	HFKEQLSKKGNYIGITSKKQAMSLPVERCLRRSGRMRRCSRCMKAGFWAKWSGSI	10.0	9.0	-	-	4316_17:63530030-63530030 ->TA_HFKEQLSKKGNYIGITSKKQAMSLPVERCLRRSGRMRRCSRCMKAGFWAKWSGSI	0.0
3:69988295-69988295 C>T	1.0	3784	MELANOMA	-	-	-	1	MITF	ENST00000478490,p.P103L	protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000478490	nonsynonymous SNV	exon3	c.C308T	p.P103L	KFEEQNRAESECPDG	KFEEQNRAESECLDG	10.0	2.0	-	-	3784_3:69988295-69988295 C>T_KFEEQNRAESECLDG	0.0
17:3567983-3567983 T>G	1.0	4298	COLORECTAL	-	-	-	-	TAX1BP3	uc002fwe.1,p.K50T	protein_coding	uc002fwe.1	nonsynonymous SNV	exon2	c.A149C	p.K50T	DQDPSQNPFSEDKTDKVRGSGVLGP	DQDPSQNPFSEDTTDKVRGSGVLGP	8.0	7.0	-	-	4298_17:3567983-3567983 T>G_DQDPSQNPFSEDTTDKVRGSGVLGP	0.0
15:34133059-34133059 G>A	1.0	3903	MELANOMA	-	-	-	-	RYR3	ENST00000389232,p.G4338R|uc001zhi.3,p.G4338R|NM_001036,p.G4338R|uc010bar.3,p.G4333R|ENST00000415757,p.G4333R|NM_001243996,p.G4333R	retained_intron, protein_coding, processed_transcript	uc010bar.3	nonsynonymous SNV	exon89	c.G12997A	p.G4333R	QAAEMKAANEAEGKVESEKADMEDG	QAAEMKAANEAERKVESEKADMEDG	3.0	6.0	-	-	3903_15:34133059-34133059 G>A_QAAEMKAANEAERKVESEKADMEDG	0.0
3:140401414-140401414 G>A	0.0	4177	PANCREATIC	-	-	-	-	TRIM42	uc003eto.2,p.R151Q|NM_152616,p.R151Q|ENST00000286349,p.R151Q	protein_coding	uc003eto.2	nonsynonymous SNV	exon2	c.G452A	p.R151Q	HLVNHLNCPMCSRLRLHSFMLPCNH	HLVNHLNCPMCSQLRLHSFMLPCNH	1.0	9.0	-	-	4177_3:140401414-140401414 G>A_HLVNHLNCPMCSQLRLHSFMLPCNH	0.0
6:89891741-89891741 G>A	1.0	4213	COLORECTAL	-	-	-	-	GABRR1	ENST00000454853,p.R278C|NM_001256703,p.R261C|ENST00000435811,p.R261C|uc031spe.1,p.R191C|NM_002042,p.R278C|uc011dzw.2,p.R191C|uc003pna.2,p.R278C|ENST00000369451,p.R191C|NM_001256704,p.R191C|uc011dzv.2,p.R261C|NM_001267582,p.R191C	protein_coding, processed_transcript, nonsense_mediated_decay	uc031spe.1	nonsynonymous SNV	exon10	c.C571T	p.R191C	GWYNRLYINFTLRRHIFFFLLQTYF	GWYNRLYINFTLCRHIFFFLLQTYF	4.0	6.0	-	-	4213_6:89891741-89891741 G>A_GWYNRLYINFTLCRHIFFFLLQTYF	0.0
17:7498072-7498072 G>C	1.0	3716	MELANOMA	-	-	-	-	FXR2	NM_004860,p.P279A|uc002gia.2,p.P279A|ENST00000250113,p.P279A	retained_intron, protein_coding, processed_transcript	uc002gia.2	nonsynonymous SNV	exon9	c.C835G	p.P279A	EETCTFRIYGETPEACRQARSYLEF	EETCTFRIYGETAEACRQARSYLEF	6.0	8.0	-	-	3716_17:7498072-7498072 G>C_EETCTFRIYGETAEACRQARSYLEF	0.0
10:115381935-115381935 T>G	0.0	4298	COLORECTAL	-	-	-	-	NRAP	uc001laj.4,p.K821T|ENST00000360478,p.K786T|NM_198060,p.K821T|NM_006175,p.K786T|ENST00000369358,p.K829T|ENST00000359988,p.K821T|uc001lal.4,p.K821T|uc001lak.4,p.K786T|NM_001261463,p.K821T|ENST00000369360,p.K794T	protein_coding	uc001lal.4	nonsynonymous SNV	exon24	c.A2462C	p.K821T	AAKAKRDLASEVKYKEDYERSRGKL	AAKAKRDLASEVTYKEDYERSRGKL	1.0	7.0	-	-	4298_10:115381935-115381935 T>G_AAKAKRDLASEVTYKEDYERSRGKL	0.0
X:65822562-65822562 T>A	0.0	4246	COLORECTAL	-	-	-	-	EDA2R	NM_001199687,p.S144C|ENST00000396050,p.S144C|NM_001242310,p.S144C|uc004dwq.3,p.S144C|uc004dwr.3,p.S144C|NM_021783,p.S144C|ENST00000456230,p.S144C|ENST00000374719,p.S144C|uc004dws.3,p.S144C|uc004dwt.2,p.S144C|ENST00000450752,p.S144C|uc022byh.1,p.S144C|ENST00000253392,p.S144C	protein_coding	uc022byh.1	nonsynonymous SNV	exon4	c.A430T	p.S144C	VPPQEATLVALVSSLLVVFTLAFLG	VPPQEATLVALVCSLLVVFTLAFLG	2.0	5.0	-	-	4246_X:65822562-65822562 T>A_VPPQEATLVALVCSLLVVFTLAFLG	0.0
10:63851320-63851320 A>G	0.0	4320	COLORECTAL	-	-	-	-	ARID5B	uc001jlu.2,p.S457G|NM_001244638,p.S457G|NM_032199,p.S700G|ENST00000309334,p.S457G|uc001jlt.2,p.S700G|ENST00000279873,p.S700G	protein_coding	uc001jlu.2	nonsynonymous SNV	exon7	c.A1369G	p.S457G	SPLAKKKLLSQVSGASLSSSYPYGS	SPLAKKKLLSQVGGASLSSSYPYGS	7.0	2.0	-	-	4320_10:63851320-63851320 A>G_SPLAKKKLLSQVGGASLSSSYPYGS	0.0
9:131513469-131513469 G>A	1.0	4237	NSCLC	-	-	-	-	ZER1	uc004bwa.2,p.R373W|NM_006336,p.R373W|ENST00000291900,p.R373W	protein_coding, processed_transcript	uc004bwa.2	nonsynonymous SNV	exon7	c.C1117T	p.R373W	EAYTEHRPEITSRAINLLFDIARIE	EAYTEHRPEITSWAINLLFDIARIE	9.0	6.0	-	-	4237_9:131513469-131513469 G>A_EAYTEHRPEITSWAINLLFDIARIE	0.0
1:210267705-210267705 G>A	1.0	4000	MELANOMA	-	-	-	-	SYT14	ENST00000367019,p.D161N|uc010pso.3,p.D123N|uc009xcv.4,p.D161N|ENST00000537238,p.D123N|ENST00000472886,p.D161N|NM_001256006,p.D123N|ENST00000422431,p.D206N|NM_001146262,p.D161N|ENST00000534859,p.D161N|NM_001146264,p.D206N|NM_153262,p.D161N|ENST00000399639,p.D161N|uc010psn.3,p.D206N|uc001hhs.5,p.D206N|uc001hht.5,p.D161N|ENST00000367015,p.D123N|NM_001146261,p.D206N	protein_coding, processed_transcript	uc010pso.3	nonsynonymous SNV	exon6	c.G367A	p.D123N	NCIQRMRRTPPLDELQPPPYQDDSG	NCIQRMRRTPPLNELQPPPYQDDSG	7.0	5.0	-	-	4000_1:210267705-210267705 G>A_NCIQRMRRTPPLNELQPPPYQDDSG	0.0
17:58133502-58133502 G>A	1.0	3998	MELANOMA	-	-	-	-	HEATR6	NM_022070,p.P726S|uc002iyk.1,p.P726S|ENST00000184956,p.P726S|uc010ddk.1,p.P265S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ddk.1	nonsynonymous SNV	exon5	c.C793T	p.P265S	GEVICKCMGEADPSIQLHGAKLLEE	GEVICKCMGEADSSIQLHGAKLLEE	7.0	4.0	-	-	3998_17:58133502-58133502 G>A_GEVICKCMGEADSSIQLHGAKLLEE	0.0
15:49421687-49421687 G>A	1.0	4278	COLORECTAL	-	-	-	-	COPS2	ENST00000542928,p.P308L|NM_004236,p.P372L|uc001zxf.3,p.P372L|ENST00000388901,p.P372L|NM_001143887,p.P379L|uc010ufa.2,p.P308L|uc001zxh.3,p.P379L|ENST00000299259,p.P379L	retained_intron, protein_coding, nonsense_mediated_decay	uc010ufa.2	nonsynonymous SNV	exon9	c.C923T	p.P308L	IKLIKPYTRIHIPFISKELNIDVAD	IKLIKPYTRIHILFISKELNIDVAD	9.0	2.0	CD8	-	4278_15:49421687-49421687 G>A_IKLIKPYTRIHILFISKELNIDVAD	1.0
12:69113358-69113358 G>A	1.0	3903	MELANOMA	-	-	-	-	NUP107	NM_020401,p.G392E|ENST00000378905,p.G241E|ENST00000539906,p.G363E|uc001suf.3,p.G392E|uc001sug.3,p.G239E|ENST00000229179,p.G392E|uc010stj.2,p.G363E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010stj.2	nonsynonymous SNV	exon14	c.G1088A	p.G363E	GWKLYHDPNVNGGTELEPVEGNPYR	GWKLYHDPNVNGETELEPVEGNPYR	8.0	3.0	-	-	3903_12:69113358-69113358 G>A_GWKLYHDPNVNGETELEPVEGNPYR	0.0
18:70423380-70423380 G>A	0.0	4301	MELANOMA	-	-	-	-	NETO1	ENST00000299430,p.P290S|NM_138966,p.P291S|NM_001201465,p.P291S|uc002lkw.3,p.P291S|uc002lky.2,p.P291S|ENST00000327305,p.P291S|ENST00000583169,p.P291S	protein_coding, processed_transcript	uc002lky.2	nonsynonymous SNV	exon8	c.C871T	p.P291S	RFQMLFTSFQEPPCEGNTFFCHSNM	RFQMLFTSFQEPSCEGNTFFCHSNM	6.0	8.0	-	-	4301_18:70423380-70423380 G>A_RFQMLFTSFQEPSCEGNTFFCHSNM	0.0
17:73236026-73236026 G>A	1.0	2369	MELANOMA	0.0009	-	-	-	GGA3	ENST00000582717,p.A404V|NM_138619,p.A476V|ENST00000351904,p.A443V|ENST00000582486,p.A404V|NM_014001,p.A443V|NM_001172704,p.A354V|uc002jnj.2,p.A443V|uc010wrw.2,p.A354V|NM_001172703,p.A404V|uc002jnk.2,p.A404V|ENST00000245541,p.A476V|NM_001291642,p.A354V|uc010wry.2,p.A404V|NM_001291641,p.A404V|ENST00000538886,p.A354V|ENST00000578348,p.A354V|uc010wrx.2,p.A354V|uc002jni.2,p.A476V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wry.2	nonsynonymous SNV	exon13	c.C1211T	p.A404V	PFPAPVVPASVPAPSAGSSLFSTGV	PFPAPVVPASVPVPSAGSSLFSTGV	8.0	6.0	-	-	2369_17:73236026-73236026 G>A_PFPAPVVPASVPVPSAGSSLFSTGV	0.0
9:123877420-123877420 A>G	1.0	3713	MELANOMA	-	-	-	1	CNTRL	NM_007018,p.Q466R|uc004bky.1,p.Q70R|ENST00000373855,p.Q466R|ENST00000238341,p.Q466R|uc004bkx.1,p.Q466R	protein_coding, processed_transcript	uc004bky.1	nonsynonymous SNV	exon3	c.A209G	p.Q70R	SELHDEIEKAEQQILRATEEFKQLE	SELHDEIEKAEQRILRATEEFKQLE	4.0	10.0	-	-	3713_9:123877420-123877420 A>G_SELHDEIEKAEQRILRATEEFKQLE	0.0
6:152711556-152711556 A>C	0.0	4160	COLORECTAL	-	-	-	-	SYNE1	ENST00000423061,p.V2686G|ENST00000448038,p.V2686G|NM_182961,p.V2679G|uc003qot.4,p.V2686G|ENST00000367255,p.V2679G|ENST00000341594,p.V2718G|uc003qou.4,p.V2679G|uc010kjb.1,p.V2662G|ENST00000265368,p.V2679G|NM_033071,p.V2686G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kjb.1	nonsynonymous SNV	exon51	c.T7985G	p.V2662G	IQDILLMKGEGEVKLNMAIGKGEQA	IQDILLMKGEGEGKLNMAIGKGEQA	6.0	4.0	-	-	4160_6:152711556-152711556 A>C_IQDILLMKGEGEGKLNMAIGKGEQA	0.0
12:132549264-132549264 C>T	1.0	2359	MELANOMA	-	-	-	-	EP400	uc001ujn.3,p.P2796S|ENST00000389561,p.P2796S|uc001ujm.3,p.P2715S|ENST00000332482,p.P2759S|NM_015409,p.P2796S|ENST00000389562,p.P2795S|ENST00000333577,p.P2832S|uc001ujp.3,p.P13S|ENST00000330386,p.P2715S	protein_coding, processed_transcript	uc001ujp.3	nonsynonymous SNV	exon2	c.C37T	p.P13S	MQKQKLQMPPQPPPPQAQSAPPQPT	MQKQKLQMPPQPSPPQAQSAPPQPT	7.0	6.0	-	-	2359_12:132549264-132549264 C>T_MQKQKLQMPPQPSPPQAQSAPPQPT	0.0
19:16677428-16677428 T>G	1.0	4071	COLORECTAL	-	-	-	-	SLC35E1	ENST00000409035,p.T418P	 protein_coding, processed_transcript,retained_intron, nonsense_mediated_decay	ENST00000409035	nonsynonymous SNV	exon5	c.A1252C	p.T418P	CEIHGSTISGCSTSWAATPSSL	CEIHGSTISGCSPSWAATPSSL	9.0	4.0	-	-	4071_19:16677428-16677428 T>G_CEIHGSTISGCSPSWAATPSSL	0.0
X:153670602-153670602 A>C	1.0	4317	COLORECTAL	-	-	-	-	GDI1	ENST00000447750,p.K379T|uc004flj.3,p.K44T|uc004fli.4,p.K379T|NM_001493,p.K379T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004flj.3	nonsynonymous SNV	exon1	c.A131C	p.K44T	EPALELLEPIDQKFVAISDLYEPID	EPALELLEPIDQTFVAISDLYEPID	10.0	4.0	-	-	4317_X:153670602-153670602 A>C_EPALELLEPIDQTFVAISDLYEPID	0.0
6:42796870-42796870 G>C	0.0	4149	OVARIAN	-	-	-	-	GLTSCR1L	NM_015349,p.G267R|uc003osn.1,p.G267R|ENST00000394168,p.G267R|uc003osm.1,p.G267R|uc003osp.1,p.G267R|ENST00000314073,p.G267R|uc011duw.1,p.G267R|uc003oso.1,p.G267R	protein_coding	uc011duw.1	nonsynonymous SNV	exon5	c.G799C	p.G267R	VHRQTPNGNSLFGNSSSSPVAQPVT	VHRQTPNGNSLFRNSSSSPVAQPVT	6.0	3.0	-	-	4149_6:42796870-42796870 G>C_VHRQTPNGNSLFRNSSSSPVAQPVT	0.0
1:35250779-35250779 T>A	1.0	4335	COLORECTAL	-	-	-	-	GJB3	NM_001005752,p.L139H|uc001bxz.4,p.L139H|uc001bxx.3,p.L139H|ENST00000373366,p.L139H|ENST00000373362,p.L139H|NM_024009,p.L139H|uc001bxy.3,p.L139H	protein_coding	uc001bxz.4	nonsynonymous SNV	exon1	c.T416A	p.L139H	LWWTYLFSLIFKLIIEFLFLYLLHT	LWWTYLFSLIFKHIIEFLFLYLLHT	8.0	6.0	-	-	4335_1:35250779-35250779 T>A_LWWTYLFSLIFKHIIEFLFLYLLHT	0.0
11:17793657-17793657 G>A	0.0	4301	MELANOMA	-	-	-	-	KCNC1	uc009yhc.1,p.R339Q|NM_004976,p.R339Q|NM_001112741,p.R339Q|ENST00000379472,p.R339Q|uc001mnk.4,p.R339Q|ENST00000265969,p.R339Q	retained_intron, protein_coding, processed_transcript	uc009yhc.1	nonsynonymous SNV	exon2	c.G1016A	p.R339Q	HFVGLRVLGHTLRASTNEFLLLIIF	HFVGLRVLGHTLQASTNEFLLLIIF	1.0	7.0	-	-	4301_11:17793657-17793657 G>A_HFVGLRVLGHTLQASTNEFLLLIIF	0.0
X:85906066-85906066 C>T	0.0	4245	COLORECTAL	-	-	-	-	DACH2	NM_001139515,p.A56V|uc011mra.1,p.A56V|uc004eex.2,p.A210V|ENST00000461604,p.A223V|ENST00000373131,p.A210V|ENST00000373125,p.A223V|ENST00000508860,p.A56V|NM_001139514,p.A210V|uc004eew.2,p.A223V|uc010nmq.2,p.A89V|NM_053281,p.A223V	protein_coding, processed_transcript, nonsense_mediated_decay	uc011mra.1	nonsynonymous SNV	exon4	c.C167T	p.A56V	TPTGITAAAMAEAMKLQKMKLMAMN	TPTGITAAAMAEVMKLQKMKLMAMN	3.0	10.0	-	-	4245_X:85906066-85906066 C>T_TPTGITAAAMAEVMKLQKMKLMAMN	0.0
11:118183543-118183543 C>T	0.0	4155	MELANOMA	-	-	-	-	CD3E	uc001psq.4,p.P105L|ENST00000361763,p.P105L|ENST00000528600,p.P99L|uc010rya.2,p.P105L|NM_000733,p.P105L	retained_intron, protein_coding	uc010rya.2	nonsynonymous SNV	exon6	c.C314T	p.P105L	SGYYVCYPRGSKPEDANFYLYLRAR	SGYYVCYPRGSKLEDANFYLYLRAR	4.0	3.0	-	-	4155_11:118183543-118183543 C>T_SGYYVCYPRGSKLEDANFYLYLRAR	0.0
3:119445098-119445098 C>T	0.0	3903	MELANOMA	-	-	-	-	MAATS1	NM_033364,p.P255S|uc011bjd.2,p.P129S|uc010hra.2,p.P16S|uc010hqy.2,p.P255S|uc010hqz.3,p.P193S|ENST00000273390,p.P255S|uc003ede.4,p.P255S|uc011bje.2,p.P235S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bje.2	nonsynonymous SNV	exon7	c.C703T	p.P235S	RAREKRAWEASLPALSDTSQFEKRR	RAREKRAWEASLSALSDTSQFEKRR	1.0	2.0	-	-	3903_3:119445098-119445098 C>T_RAREKRAWEASLSALSDTSQFEKRR	0.0
15:66853612-66853612 C>T	0.0	2591	MELANOMA	-	-	-	-	LCTL	ENST00000341509,p.M174I|uc002aqc.3,p.M174I|NM_207338,p.M174I	protein_coding, processed_transcript, nonsense_mediated_decay	uc002aqc.3	nonsynonymous SNV	exon5	c.G522A	p.M174I	LQVKYGGWQNVSMANYFRDYANLCF	LQVKYGGWQNVSIANYFRDYANLCF	5.0	1.0	-	-	2591_15:66853612-66853612 C>T_LQVKYGGWQNVSIANYFRDYANLCF	0.0
7:21469240-21469240 G>A	0.0	4149	OVARIAN	-	-	-	-	SP4	uc003sva.3,p.V153I|ENST00000222584,p.V153I|NM_003112,p.V153I	retained_intron, protein_coding, nonsense_mediated_decay	uc003sva.3	nonsynonymous SNV	exon3	c.G457A	p.V153I	KSGNSSTPGQFQVIQVQNPSGSVQY	KSGNSSTPGQFQIIQVQNPSGSVQY	4.0	1.0	-	-	4149_7:21469240-21469240 G>A_KSGNSSTPGQFQIIQVQNPSGSVQY	0.0
13:39264378-39264378 C>T	0.0	4287	COLORECTAL	-	-	-	-	FREM2	NM_207361,p.A966V|uc001uwv.3,p.A966V|ENST00000280481,p.A966V	protein_coding, processed_transcript	uc001uwv.3	nonsynonymous SNV	exon1	c.C2897T	p.A966V	LDVLENGATEITANVIKGTNEETDD	LDVLENGATEITVNVIKGTNEETDD	6.0	8.0	-	-	4287_13:39264378-39264378 C>T_LDVLENGATEITVNVIKGTNEETDD	0.0
4:2945938-2945938 G>A	1.0	3879	MELANOMA	-	-	-	-	NOP14	uc010icp.2,p.L331F|uc003ggl.3,p.L585F|ENST00000416614,p.L585F|uc003ggj.1,p.L585F|NM_003703,p.L585F|ENST00000314262,p.L585F|ENST00000398071,p.L585F|ENST00000502735,p.L585F|NM_001291979,p.L585F|NM_001291978,p.L585F	protein_coding, processed_transcript	uc010icp.2	nonsynonymous SNV	exon9	c.C991T	p.L331F	LSQLLTKCPILSLQDVVKGLFVCCL	LSQLLTKCPILSFQDVVKGLFVCCL	8.0	4.0	-	-	3879_4:2945938-2945938 G>A_LSQLLTKCPILSFQDVVKGLFVCCL	0.0
3:127398985-127398985 T>C	0.0	4345	COLORECTAL	-	-	-	-	ABTB1	ENST00000468137,p.L254P|uc003ejt.3,p.L396P|ENST00000393363,p.L254P|NM_172027,p.L396P|uc010hsm.3,p.L123P|NM_032548,p.L254P|uc003eju.3,p.L254P|ENST00000453791,p.L254P|uc003ejr.3,p.L254P|ENST00000232744,p.L396P|uc003ejs.3,p.L371P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010hsm.3	nonsynonymous SNV	exon4	c.T368C	p.L123P	VWRVAKLFRLARLEDQCTEYMAKVI	VWRVAKLFRLARPEDQCTEYMAKVI	7.0	6.0	-	-	4345_3:127398985-127398985 T>C_VWRVAKLFRLARPEDQCTEYMAKVI	0.0
14:69702800-69702800 C>T	1.0	4000	MELANOMA	-	-	-	-	EXD2	uc001xkw.3,p.P238S|ENST00000409242,p.P238S|uc010tte.2,p.P363S|NM_001193363,p.P363S|NM_001193362,p.P363S|NM_001193360,p.P363S|uc001xkv.3,p.P363S|uc001xkx.3,p.P238S|NM_018199,p.P238S|uc010aqt.3,p.P363S|ENST00000409675,p.P238S|uc001xky.3,p.P363S|ENST00000449989,p.P238S|ENST00000409949,p.P238S|uc001xku.3,p.P108S|uc001xkt.3,p.P238S|ENST00000409018,p.P363S|ENST00000409014,p.P238S|ENST00000312994,p.P363S|NM_001193361,p.P363S	retained_intron, protein_coding, processed_transcript	uc010tte.2	nonsynonymous SNV	exon6	c.C1087T	p.P363S	KSPLYDNCFLHAPDGQPLCTCDRRK	KSPLYDNCFLHASDGQPLCTCDRRK	7.0	3.0	-	-	4000_14:69702800-69702800 C>T_KSPLYDNCFLHASDGQPLCTCDRRK	0.0
11:76893105-76893105 G>A	0.0	4129	NSCLC	-	-	-	-	MYO7A	uc009yut.1,p.A216T|uc001oyc.2,p.A1005T|NM_001127180,p.A1005T|uc001oyd.3,p.A345T|ENST00000458637,p.A1005T|NM_000260,p.A1005T|ENST00000409619,p.A994T|uc001oyb.2,p.A1005T|ENST00000409709,p.A1005T|uc010rsl.2,p.A1005T|NM_001127179,p.A1005T|ENST00000458169,p.A186T|uc010rsm.1,p.A994T|ENST00000409893,p.A1005T	retained_intron, protein_coding, processed_transcript	uc010rsm.1	nonsynonymous SNV	exon25	c.G2980A	p.A994T	EEDLSEYKFAKFAATYFQGTTTHSY	EEDLSEYKFAKFTATYFQGTTTHSY	6.0	9.0	-	-	4129_11:76893105-76893105 G>A_EEDLSEYKFAKFTATYFQGTTTHSY	0.0
9:135917636-135917636 G>A	1.0	4160	COLORECTAL	-	-	-	-	GTF3C5	uc004cci.4,p.E106K|uc004ccj.4,p.E106K|ENST00000440319,p.E59K|ENST00000372097,p.E106K|NM_001122823,p.E106K|ENST00000342018,p.E106K|ENST00000372099,p.E97K|NM_012087,p.E106K|ENST00000372108,p.E106K	protein_coding, processed_transcript	uc004ccj.4	nonsynonymous SNV	exon2	c.G316A	p.E106K	RQKGVLGTEAHSEVTFDMEILGIIS	RQKGVLGTEAHSKVTFDMEILGIIS	10.0	7.0	-	-	4160_9:135917636-135917636 G>A_RQKGVLGTEAHSKVTFDMEILGIIS	0.0
11:94592771-94592771 C>T	0.0	4259	COLORECTAL	-	-	-	-	AMOTL1	uc001pfb.3,p.R676W|ENST00000317829,p.R626W|NM_130847,p.R676W|uc001pfc.3,p.R626W|ENST00000433060,p.R676W|NM_001301007,p.R626W	retained_intron, protein_coding, processed_transcript	uc001pfc.3	nonsynonymous SNV	exon8	c.C1876T	p.R626W	PALLELVREKEERILALEADMTKWE	PALLELVREKEEWILALEADMTKWE	6.0	7.0	-	-	4259_11:94592771-94592771 C>T_PALLELVREKEEWILALEADMTKWE	0.0
X:24228853-24228853 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM1119454;OCCURENCE=1(endometrium)	-	ZFX	uc010nfz.3,p.T249M|ENST00000379188,p.T593M|uc004dbd.2,p.T593M|NM_001178085,p.T593M|ENST00000540034,p.T632M|NM_001178086,p.T364M|NM_001178084,p.T593M|uc010nfx.2,p.T364M|ENST00000539115,p.T364M|ENST00000379177,p.T593M|ENST00000338565,p.T543M|ENST00000304543,p.T593M|uc022bua.1,p.T593M|uc011mjv.2,p.T632M|NM_003410,p.T593M|uc004dbf.3,p.T593M	protein_coding, processed_transcript	uc022bua.1	nonsynonymous SNV	exon8	c.C1778T	p.T593M	CEYRSADSSNLKTHVKTKHSKEMPF	CEYRSADSSNLKMHVKTKHSKEMPF	9.0	6.0	-	-	4196_X:24228853-24228853 C>T_CEYRSADSSNLKMHVKTKHSKEMPF	0.0
6:32117436-32117436 C>T	0.0	4189	MELANOMA	-	-	-	-	PRRT1	uc003nzu.3,p.G100E	retained_intron, protein_coding, processed_transcript	uc003nzu.3	nonsynonymous SNV	exon5	c.G299A	p.G100E	NRSDLHSPPAAPGPRAGPTGAEAPA	NRSDLHSPPAAPEPRAGPTGAEAPA	5.0	6.0	-	-	4189_6:32117436-32117436 C>T_NRSDLHSPPAAPEPRAGPTGAEAPA	0.0
4:25005702-25005702 C>T	0.0	3903	MELANOMA	-	-	-	-	LGI2	ENST00000382114,p.E337K|NM_018176,p.E337K|uc003grf.2,p.E337K	protein_coding	uc003grf.2	nonsynonymous SNV	exon8	c.G1009A	p.E337K	KPNDIELFQIDDETFFVIADSSKAG	KPNDIELFQIDDKTFFVIADSSKAG	3.0	6.0	-	-	3903_4:25005702-25005702 C>T_KPNDIELFQIDDKTFFVIADSSKAG	0.0
9:35556365-35556365 C>T	1.0	4275	COLORECTAL	0.0014	-	ID=COSM1195986;OCCURENCE=1(lung)	-	RUSC2	uc003zww.3,p.T968M|ENST00000361226,p.T968M|NM_014806,p.T968M|NM_001135999,p.T968M|ENST00000455600,p.T968M|uc003zwx.4,p.T968M	protein_coding, processed_transcript	uc003zwx.4	nonsynonymous SNV	exon5	c.C2903T	p.T968M	LTCPDFQDPFSLTEKPPAEFCLSPD	LTCPDFQDPFSLMEKPPAEFCLSPD	6.0	5.0	-	-	4275_9:35556365-35556365 C>T_LTCPDFQDPFSLMEKPPAEFCLSPD	0.0
12:6494516-6494516 G>A	1.0	4180	BREAST	-	-	-	-	LTBR	ENST00000539925,p.C129Y|ENST00000541102,p.C41Y|ENST00000228918,p.C148Y|uc001qny.2,p.C148Y|NM_001270987,p.C129Y|uc010sfc.2,p.C129Y|ENST00000544454,p.C41Y|uc001qnz.2,p.C143Y|ENST00000536876,p.C143Y|NM_002342,p.C148Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sfc.2	nonsynonymous SNV	exon4	c.G386A	p.C129Y	ALECTHCELLSDCPPGTEAELKDEV	ALECTHCELLSDYPPGTEAELKDEV	10.0	6.0	-	-	4180_12:6494516-6494516 G>A_ALECTHCELLSDYPPGTEAELKDEV	0.0
14:92491728-92491728 C>T	0.0	2591	MELANOMA	-	-	ID=COSM553972;OCCURENCE=1(lung)	1	TRIP11	NM_004239,p.E80K|ENST00000267622,p.E80K|uc001xzy.3,p.E80K	protein_coding, processed_transcript, nonsense_mediated_decay	uc001xzy.3	nonsynonymous SNV	exon3	c.G238A	p.E80K	NERLKKLCTDLEEKHEASEIQIKQQ	NERLKKLCTDLEKKHEASEIQIKQQ	6.0	3.0	-	-	2591_14:92491728-92491728 C>T_NERLKKLCTDLEKKHEASEIQIKQQ	0.0
16:1391303-1391303 G>T	0.0	4126	NSCLC	-	-	-	-	BAIAP3	NM_003933,p.D217Y|ENST00000397488,p.D199Y|uc021tag.1,p.D159Y|uc002clj.3,p.D199Y|uc010uva.2,p.D154Y|ENST00000426824,p.D182Y|NM_001199097,p.D182Y|NM_001286464,p.D199Y|ENST00000397489,p.D199Y|uc010uuz.2,p.D182Y|ENST00000562208,p.D159Y|ENST00000324385,p.D217Y|ENST00000568887,p.D154Y|uc010uvc.1,p.D182Y|uc010uvb.2,p.D234Y|NM_001199099,p.D154Y|NM_001199096,p.D182Y|ENST00000421665,p.D182Y|NM_001199098,p.D159Y|uc002clk.2,p.D217Y	retained_intron, protein_coding, processed_transcript	uc021tag.1	nonsynonymous SNV	exon8	c.G475T	p.D159Y	KNLLAKDPNGFSDPYCMLGILPASD	KNLLAKDPNGFSYPYCMLGILPASD	6.0	6.0	-	-	4126_16:1391303-1391303 G>T_KNLLAKDPNGFSYPYCMLGILPASD	0.0
2:219514078-219514078 G>A	1.0	3903	MELANOMA	-	-	-	-	ZNF142	uc002vil.3,p.H146Y|NM_001105537,p.H185Y|uc002vin.4,p.H185Y|ENST00000449707,p.H185Y|uc010fvt.4,p.H22Y|ENST00000411696,p.H185Y|uc002vim.4,p.H22Y	protein_coding, nonsense_mediated_decay	uc010fvt.4	nonsynonymous SNV	exon7	c.C64T	p.H22Y	KKRTHLVEHLHLHFPDPSLQCPNCQ	KKRTHLVEHLHLYFPDPSLQCPNCQ	7.0	9.0	-	-	3903_2:219514078-219514078 G>A_KKRTHLVEHLHLYFPDPSLQCPNCQ	0.0
7:66406970-66406970 T>G	1.0	4287	COLORECTAL	-	-	-	-	TMEM248	ENST00000424964,p.F40V|ENST00000413593,p.F40V|ENST00000341567,p.F40V|uc003tvk.3,p.F40V|ENST00000433271,p.F40V|ENST00000418375,p.F40V|ENST00000607045,p.F40V|NM_017994,p.F40V	retained_intron, protein_coding, nonsense_mediated_decay	uc003tvk.3	nonsynonymous SNV	exon2	c.T118G	p.F40V	SAMAIAFLTLGYFFKIKEIKSPEMA	SAMAIAFLTLGYVFKIKEIKSPEMA	9.0	5.0	-	-	4287_7:66406970-66406970 T>G_SAMAIAFLTLGYVFKIKEIKSPEMA	0.0
10:97810020-97810020 A>C	0.0	4345	COLORECTAL	-	-	-	-	CCNJ	NM_001134375,p.K26T|NM_019084,p.K26T|ENST00000534974,p.K26T|NM_001134376,p.K26T|ENST00000465148,p.K26T|uc010qoq.2,p.K26T|ENST00000403870,p.K26T|ENST00000265992,p.K26T|uc001kln.3,p.K26T|uc001klm.3,p.K26T	protein_coding, processed_transcript, nonsense_mediated_decay	uc010qoq.2	nonsynonymous SNV	exon3	c.A77C	p.K26T	ADIHQALRYKELKLPSYKGQSPQLS	ADIHQALRYKELTLPSYKGQSPQLS	4.0	6.0	-	-	4345_10:97810020-97810020 A>C_ADIHQALRYKELTLPSYKGQSPQLS	0.0
10:70406510-70406510 C>G	0.0	3775	CERVICAL	-	-	-	1	TET1	NM_030625,p.H1342D|ENST00000373644,p.H1342D|uc001jok.4,p.H1342D	protein_coding	uc001jok.4	nonsynonymous SNV	exon4	c.C4024G	p.H1342D	MHQRLPTLPGISHETPLPESALTLR	MHQRLPTLPGISDETPLPESALTLR	2.0	6.0	-	-	3775_10:70406510-70406510 C>G_MHQRLPTLPGISDETPLPESALTLR	0.0
1:231298819-231298819 C>T	0.0	4278	COLORECTAL	-	-	-	-	TRIM67	ENST00000449018,p.A35V|NM_001300889,p.A35V	protein_coding	NM_001300889	nonsynonymous SNV	exon1	c.C104T	p.A35V	SHNVCLPCARTIAVQTPDGGSAAGG	SHNVCLPCARTIVVQTPDGGSAAGG	1.0	6.0	-	-	4278_1:231298819-231298819 C>T_SHNVCLPCARTIVVQTPDGGSAAGG	0.0
2:25358487-25358487 G>A	1.0	4259	COLORECTAL	-	-	-	-	EFR3B	uc010eyh.3,p.R488H|ENST00000403714,p.R488H|NM_014971,p.R488H|uc002rfw.2,p.R488H|ENST00000264719,p.R367H|ENST00000401432,p.R488H|ENST00000402191,p.R453H|ENST00000405108,p.R340H	protein_coding	uc010eyh.3	nonsynonymous SNV	exon13	c.G1463A	p.R488H	EILISFIDRHGNRHKFSTISTLSDI	EILISFIDRHGNHHKFSTISTLSDI	5.0	9.0	-	-	4259_2:25358487-25358487 G>A_EILISFIDRHGNHHKFSTISTLSDI	0.0
19:54691142-54691142 C>G	1.0	4335	COLORECTAL	-	-	-	-	MBOAT7	uc010yem.2,p.W60C|ENST00000245615,p.W78C|ENST00000391754,p.W78C|NM_024298,p.W78C|ENST00000449249,p.W30C|ENST00000453320,p.W78C|NM_001146082,p.W78C|uc002qdr.3,p.W78C|uc002qdt.4,p.W78C|uc002qdq.3,p.W78C|ENST00000414665,p.W78C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yem.2	nonsynonymous SNV	exon2	c.G180C	p.W60C	AQPCSCHALALAWTFSYLLFFRALS	AQPCSCHALALACTFSYLLFFRALS	6.0	10.0	-	-	4335_19:54691142-54691142 C>G_AQPCSCHALALACTFSYLLFFRALS	0.0
10:135089031-135089031 C>T	0.0	4287	COLORECTAL	0.01	-	-	-	ADAM8	ENST00000486609,p.R36H|NM_001164489,p.R36H|ENST00000415217,p.R36H|ENST00000445355,p.R36H|uc021qbe.1,p.R36H|uc009ybi.3,p.R36H|NM_001109,p.R36H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qbe.1	nonsynonymous SNV	exon2	c.G107A	p.R36H	ALMEQYEVVLPWRLPGPRVRRALPS	ALMEQYEVVLPWHLPGPRVRRALPS	6.0	10.0	-	-	4287_10:135089031-135089031 C>T_ALMEQYEVVLPWHLPGPRVRRALPS	0.0
6:33152774-33152774 C>T	1.0	4155	MELANOMA	-	-	-	-	COL11A2	ENST00000341947,p.E312K|ENST00000374714,p.E286K|NM_080680,p.E312K|ENST00000457788,p.E312K|uc003ocx.1,p.E312K	protein_coding, processed_transcript	uc003ocx.1	nonsynonymous SNV	exon7	c.G934A	p.E312K	EEILESSLLPPLEEEQTDLQVPPTA	EEILESSLLPPLKEEQTDLQVPPTA	5.0	9.0	-	-	4155_6:33152774-33152774 C>T_EEILESSLLPPLKEEQTDLQVPPTA	0.0
1:155156283-155156283 G>A	1.0	3713	MELANOMA	-	-	-	-	TRIM46	uc001fhs.2,p.D633N|NM_001256600,p.D591N|uc031pps.1,p.D620N|NM_025058,p.D633N|uc010pfa.2,p.D507N|ENST00000334634,p.D633N|uc001fhu.2,p.D610N|NM_001256599,p.D610N|ENST00000545012,p.D507N|NM_001256601,p.D620N|ENST00000368382,p.D610N|NM_001282378,p.D507N	protein_coding, processed_transcript	uc031pps.1	nonsynonymous SNV	exon10	c.G1858A	p.D620N	GAPDVISPRYDPDSGHDSGAEDATV	GAPDVISPRYDPNSGHDSGAEDATV	4.0	1.0	-	-	3713_1:155156283-155156283 G>A_GAPDVISPRYDPNSGHDSGAEDATV	0.0
20:45644820-45644820 G>T	0.0	4158	COLORECTAL	-	-	-	-	EYA2	ENST00000327619,p.S100I|ENST00000317304,p.S100I|NM_005244,p.S100I|uc010ghp.3,p.S100I|ENST00000357410,p.S100I|ENST00000458636,p.S53I|uc002xsq.3,p.S100I|uc002xsm.3,p.S100I|NM_172110,p.S100I	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ghp.3	nonsynonymous SNV	exon5	c.G299T	p.S100I	PPPAQAYGIPSYSIKTEDSLNHSPG	PPPAQAYGIPSYIIKTEDSLNHSPG	6.0	6.0	-	-	4158_20:45644820-45644820 G>T_PPPAQAYGIPSYIIKTEDSLNHSPG	0.0
12:22076755-22076755 G>C	0.0	4284	COLORECTAL	-	-	-	-	ABCC9	ENST00000326684,p.H148D|uc001rfk.3,p.H148D	protein_coding	uc001rfk.3	nonsynonymous SNV	exon7	c.C442G	p.H148D	GFSHHESKSCYQHS	GFSHHESKSCYQDS	6.0	7.0	-	-	4284_12:22076755-22076755 G>C_GFSHHESKSCYQDS	0.0
16:11990535-11990535 C>G	1.0	4134	NSCLC	-	-	-	-	GSPT1	uc002dbt.3,p.E182Q|ENST00000420576,p.E44Q|NM_002094,p.E182Q|ENST00000563468,p.E44Q|uc010bux.3,p.E44Q|uc002dbu.3,p.E181Q|NM_001130007,p.E44Q|ENST00000568849,p.E75Q|ENST00000439887,p.E181Q|ENST00000562169,p.E74Q|ENST00000434724,p.E182Q|NM_001130006,p.E181Q	retained_intron, protein_coding, processed_transcript	uc010bux.3	nonsynonymous SNV	exon4	c.G130C	p.E44Q	PGGGSLGDGRPPEESAHEMMEEEEE	PGGGSLGDGRPPQESAHEMMEEEEE	10.0	7.0	-	-	4134_16:11990535-11990535 C>G_PGGGSLGDGRPPQESAHEMMEEEEE	0.0
18:8798213-8798213 C>T	1.0	3713	MELANOMA	-	-	-	-	MTCL1	ENST00000306329,p.S1106F|ENST00000400050,p.S746F|uc002knr.2,p.S787F|ENST00000306285,p.S102F|uc002knq.2,p.S746F|uc002kns.2,p.S117F|ENST00000517570,p.S746F|NM_015210,p.S787F|ENST00000518815,p.S102F|ENST00000359865,p.S787F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kns.2	nonsynonymous SNV	exon3	c.C350T	p.S117F	SDRGCGFPVGEHSPHSRVQIGDHSL	SDRGCGFPVGEHFPHSRVQIGDHSL	6.0	1.0	-	-	3713_18:8798213-8798213 C>T_SDRGCGFPVGEHFPHSRVQIGDHSL	0.0
7:70246739-70246739 G>A	1.0	3716	MELANOMA	-	-	-	-	AUTS2	uc003tvx.4,p.A691T|ENST00000342771,p.A715T|uc003tvw.4,p.A715T|ENST00000406775,p.A691T|NM_015570,p.A715T|uc011keg.2,p.A167T|NM_001127231,p.A691T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011keg.2	nonsynonymous SNV	exon7	c.G499A	p.A167T	HDLARPSTLFSAAGAAHPTGTPFGP	HDLARPSTLFSATGAAHPTGTPFGP	8.0	3.0	-	-	3716_7:70246739-70246739 G>A_HDLARPSTLFSATGAAHPTGTPFGP	0.0
1:101004617-101004617 T>A	1.0	4301	MELANOMA	-	-	-	-	GPR88	uc021oqq.1,p.I32N|ENST00000315033,p.I32N|NM_022049,p.I32N|uc001dth.3,p.I32N	protein_coding	uc021oqq.1	nonsynonymous SNV	exon1	c.T95A	p.I32N	LCEEEESWAGRRIPVSLLYSGLAIG	LCEEEESWAGRRNPVSLLYSGLAIG	4.0	3.0	-	-	4301_1:101004617-101004617 T>A_LCEEEESWAGRRNPVSLLYSGLAIG	0.0
1:155726757-155726757 G>A	1.0	3879	MELANOMA	-	-	-	-	GON4L	uc001fly.1,p.H1837Y|uc001flz.2,p.H1837Y|NM_001282860,p.H1837Y|NM_001282858,p.H1837Y|uc001fmb.4,p.H1033Y|ENST00000368331,p.H1837Y|uc009wrh.1,p.H1837Y|ENST00000271883,p.H1837Y|ENST00000437809,p.H1837Y|NM_001282856,p.H1837Y|uc001fma.1,p.H1837Y	retained_intron, protein_coding, processed_transcript	uc009wrh.1	nonsynonymous SNV	exon27	c.C5509T	p.H1837Y	KNKRKKEIGVQNHDKETEWPDGAKD	KNKRKKEIGVQNYDKETEWPDGAKD	10.0	8.0	-	-	3879_1:155726757-155726757 G>A_KNKRKKEIGVQNYDKETEWPDGAKD	0.0
5:154397012-154397012 G>A	0.0	3466	MELANOMA	-	-	-	-	KIF4B	NM_001099293,p.G1198E|uc010jih.1,p.G1198E|ENST00000435029,p.G1198E	protein_coding	uc010jih.1	nonsynonymous SNV	exon1	c.G3593A	p.G1198E	APSPFDLPESKHGATEYQQNKPPGK	APSPFDLPESKHEATEYQQNKPPGK	1.0	9.0	-	-	3466_5:154397012-154397012 G>A_APSPFDLPESKHEATEYQQNKPPGK	0.0
8:68396015-68396015 C>G	0.0	4258	ENDOMETRIAL	-	-	-	-	CPA6	ENST00000518549,p.V276L|uc003xxs.2,p.V276L	protein_coding, nonsense_mediated_decay	uc003xxs.2	nonsynonymous SNV	exon8	c.G826C	p.V276L	RCRGVDANRNWKVKWCGKFGTNWDP	RCRGVDANRNWKLKWCGKFGTNWDP	1.0	8.0	-	-	4258_8:68396015-68396015 C>G_RCRGVDANRNWKLKWCGKFGTNWDP	0.0
9:8521438-8521438 A>G	1.0	4326	BREAST	-	-	-	-	PTPRD	NM_130392,p.V267A|ENST00000486161,p.V267A|uc003zkk.3,p.V267A|NM_001040712,p.V264A|ENST00000355233,p.V267A|NM_130391,p.V267A|uc003zks.3,p.V257A|NM_001171025,p.V257A|ENST00000381196,p.V267A|ENST00000537002,p.V264A|uc003zkr.3,p.V261A|uc003zkp.3,p.V267A|NM_130393,p.V261A|ENST00000397611,p.V264A|ENST00000358503,p.V254A|ENST00000356435,p.V267A|uc003zkq.3,p.V267A|NM_002839,p.V267A|ENST00000360074,p.V254A|ENST00000397617,p.V257A|uc022bdj.1,p.V264A|ENST00000397606,p.V257A|ENST00000540109,p.V267A	retained_intron, protein_coding, processed_transcript	uc022bdj.1	nonsynonymous SNV	exon8	c.T791C	p.V264A	ITCVAVGSPMPYVKWMLGAEDLTPE	ITCVAVGSPMPYAKWMLGAEDLTPE	5.0	9.0	-	-	4326_9:8521438-8521438 A>G_ITCVAVGSPMPYAKWMLGAEDLTPE	0.0
5:89701603-89701603 G>A	1.0	3678	MELANOMA	-	-	-	-	CETN3	ENST00000518458,p.A49V|NM_004365,p.A56V|ENST00000522565,p.A56V|uc003kjo.3,p.A56V|NM_001297765,p.A56V|ENST00000522842,p.A56V|ENST00000522083,p.A56V|NM_001297768,p.A56V|ENST00000283122,p.A56V|ENST00000522864,p.A56V	protein_coding, nonsense_mediated_decay	uc003kjo.3	nonsynonymous SNV	exon3	c.C167T	p.A56V	AIDYHELKVAMRALGFDVKKADVLK	AIDYHELKVAMRVLGFDVKKADVLK	9.0	2.0	-	-	3678_5:89701603-89701603 G>A_AIDYHELKVAMRVLGFDVKKADVLK	0.0
1:43905656-43905656 G>A	0.0	4246	COLORECTAL	-	-	-	-	SZT2	ENST00000372442,p.A1484T|ENST00000562955,p.A2326T|NM_015284,p.A2326T|uc001cjk.3,p.A2326T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001cjk.3	nonsynonymous SNV	exon50	c.G6976A	p.A2326T	EEKLRGAARQALADAIIELQLLPAS	EEKLRGAARQALTDAIIELQLLPAS	8.0	8.0	-	-	4246_1:43905656-43905656 G>A_EEKLRGAARQALTDAIIELQLLPAS	0.0
2:75425861-75425861 G>A	1.0	4284	COLORECTAL	-	-	-	-	TACR1	NM_015727,p.T67M|uc002sng.2,p.T67M|ENST00000305249,p.T67M|uc002snh.3,p.T67M|NM_001058,p.T67M|ENST00000409848,p.T67M	protein_coding, processed_transcript	uc002snh.3	nonsynonymous SNV	exon1	c.C200T	p.T67M	WIILAHKRMRTVTNYFLVNLAFAEA	WIILAHKRMRTVMNYFLVNLAFAEA	4.0	10.0	-	-	4284_2:75425861-75425861 G>A_WIILAHKRMRTVMNYFLVNLAFAEA	0.0
9:114345825-114345825 C>A	1.0	4284	COLORECTAL	-	-	-	-	PTGR1	uc010mue.3,p.G141V|NM_001146109,p.G141V|ENST00000238248,p.G18V|uc004bfj.3,p.G18V|ENST00000538962,p.G141V|NM_012212,p.G141V|NM_001146108,p.G141V|ENST00000407693,p.G141V|ENST00000309195,p.G141V|uc004bfh.2,p.G141V|uc011lwr.2,p.G141V|uc004bfi.3,p.G141V	retained_intron, protein_coding, nonsense_mediated_decay	uc011lwr.2	nonsynonymous SNV	exon6	c.G422T	p.G141V	AYFGLLEICGVKGGETVMVNAAAGA	AYFGLLEICGVKVGETVMVNAAAGA	8.0	6.0	-	-	4284_9:114345825-114345825 C>A_AYFGLLEICGVKVGETVMVNAAAGA	0.0
20:1538280-1538280 G>A	0.0	4110	BILE DUCT	-	-	-	-	SIRPD	ENST00000381621,p.P7L|uc002wfi.3,p.P7L|ENST00000381623,p.P7L|NM_178460,p.P7L	protein_coding	uc002wfi.3	nonsynonymous SNV	exon1	c.C20T	p.P7L	MPIPASPLHPPLPSLLLYL	MPIPASLLHPPLPSLLLYL	2.0	6.0	-	-	4110_20:1538280-1538280 G>A_MPIPASLLHPPLPSLLLYL	0.0
3:150690404-150690404 G>A	0.0	4346	COLORECTAL	-	-	-	-	CLRN1	uc031sbx.1,p.P31L|uc021xfv.1,p.P31L|NM_001256819,p.P31L|ENST00000327047,p.P31L|uc021xfs.1,p.P31L|uc003eyk.1,p.P31L|NM_174878,p.P31L|ENST00000328863,p.P31L|NM_001195794,p.P31L	retained_intron, protein_coding	uc031sbx.1	nonsynonymous SNV	exon1	c.C92T	p.P31L	ACALGVVTALGTPLWIKATVLCKTG	ACALGVVTALGTLLWIKATVLCKTG	1.0	10.0	-	-	4346_3:150690404-150690404 G>A_ACALGVVTALGTLLWIKATVLCKTG	0.0
1:42047820-42047820 C>A	1.0	4317	COLORECTAL	-	-	-	-	HIVEP3	NM_024503,p.E883D|uc001cgz.4,p.E883D|ENST00000372583,p.E883D|ENST00000247584,p.E883D|ENST00000429157,p.E883D|NM_001127714,p.E883D|ENST00000372584,p.E883D|uc001cha.4,p.E883D	protein_coding, processed_transcript	uc001cha.4	nonsynonymous SNV	exon3	c.G2649T	p.E883D	PEPPPKEPEKTEEFQWPQRSQTLAQ	PEPPPKEPEKTEDFQWPQRSQTLAQ	4.0	4.0	-	-	4317_1:42047820-42047820 C>A_PEPPPKEPEKTEDFQWPQRSQTLAQ	0.0
6:112510361-112510361 G>C	1.0	4284	COLORECTAL	-	-	-	-	LAMA4	uc003pvu.3,p.C255W|ENST00000521398,p.C255W|ENST00000230538,p.C255W|NM_001105206,p.C255W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003pvu.3	nonsynonymous SNV	exon7	c.C765G	p.C255W	CGGGPCDSVTGECLEEGFEPPTGMD	CGGGPCDSVTGEWLEEGFEPPTGMD	9.0	8.0	-	-	4284_6:112510361-112510361 G>C_CGGGPCDSVTGEWLEEGFEPPTGMD	0.0
7:12414647-12414647 C>T	0.0	3903	MELANOMA	-	-	-	-	VWDE	ENST00000452576,p.D411N|NM_001135924,p.D411N|ENST00000275358,p.D411N|uc003ssj.2,p.D411N	retained_intron, protein_coding, nonsense_mediated_decay	uc003ssj.2	nonsynonymous SNV	exon8	c.G1231A	p.D411N	VNEDFLWNNYIPDSIQIKVKDVPTA	VNEDFLWNNYIPNSIQIKVKDVPTA	2.0	1.0	-	-	3903_7:12414647-12414647 C>T_VNEDFLWNNYIPNSIQIKVKDVPTA	0.0
10:5790883-5790883 C>G	1.0	4266	COLORECTAL	-	-	-	-	FAM208B	uc001iik.3,p.D677E|NM_017782,p.D1833E|ENST00000328090,p.D1833E|uc001iij.3,p.D1833E	retained_intron, protein_coding, processed_transcript	uc001iik.3	nonsynonymous SNV	exon2	c.C2031G	p.D677E	DMHYELSGDSDLDLLGDCRNPRLDL	DMHYELSGDSDLELLGDCRNPRLDL	7.0	4.0	-	-	4266_10:5790883-5790883 C>G_DMHYELSGDSDLELLGDCRNPRLDL	0.0
3:195511508-195511508 T>A	1.0	4317	COLORECTAL	-	-	-	2	MUC4	ENST00000466475,p.T2315S|NM_018406,p.T2315S|ENST00000475231,p.T2315S|ENST00000477086,p.T2315S|ENST00000463781,p.T2315S|ENST00000477756,p.T2315S|ENST00000470451,p.T2315S|ENST00000480843,p.T2315S|ENST00000479406,p.T2315S|uc021xjp.1,p.T2315S|ENST00000462323,p.T2315S|ENST00000478156,p.T2315S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021xjp.1	nonsynonymous SNV	exon2	c.A6943T	p.T2315S	TPLHVTDASSASTGHATPLPVTSLS	TPLHVTDASSASSGHATPLPVTSLS	10.0	6.0	-	-	4317_3:195511508-195511508 T>A_TPLHVTDASSASSGHATPLPVTSLS	0.0
4:77661506-77661506 G>A	0.0	4189	MELANOMA	-	-	-	-	SHROOM3	uc003hkg.3,p.G505E|uc011cbz.1,p.G551E|uc011cbx.2,p.G727E|ENST00000296043,p.G727E|NM_020859,p.G727E|uc003hkf.1,p.G602E	retained_intron, protein_coding, processed_transcript	uc011cbz.1	nonsynonymous SNV	exon4	c.G1652A	p.G551E	HLDRQVSYPRPEGRTGASASFNSTD	HLDRQVSYPRPEERTGASASFNSTD	5.0	2.0	-	-	4189_4:77661506-77661506 G>A_HLDRQVSYPRPEERTGASASFNSTD	0.0
12:50153076-50153076 G>A	1.0	4000	MELANOMA	-	-	-	-	TMBIM6	NM_003217,p.A196T|ENST00000267115,p.A196T|ENST00000552699,p.A254T|uc001ruy.2,p.A254T|ENST00000395006,p.A196T|ENST00000547798,p.A159T|ENST00000549385,p.A196T|uc001rux.2,p.A196T|NM_001098576,p.A254T|uc001ruz.2,p.A196T|ENST00000423828,p.A254T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ruz.2	nonsynonymous SNV	exon8	c.G586A	p.A196T	FVLFDTQLIIEKAEHGDQDYIWHCI	FVLFDTQLIIEKTEHGDQDYIWHCI	10.0	6.0	-	-	4000_12:50153076-50153076 G>A_FVLFDTQLIIEKTEHGDQDYIWHCI	0.0
17:34068302-34068302 G>A	0.0	4160	COLORECTAL	-	-	-	-	RASL10B	ENST00000268864,p.R197H|NM_033315,p.R197H|uc002hju.3,p.R197H	protein_coding, processed_transcript	uc002hju.3	nonsynonymous SNV	exon4	c.G590A	p.R197H	VHAALRFQGALRRNRCAIM	VHAALRFQGALRHNRCAIM	5.0	9.0	-	-	4160_17:34068302-34068302 G>A_VHAALRFQGALRHNRCAIM	0.0
3:141644507-141644507 G>C	1.0	4126	NSCLC	-	-	-	-	ATP1B3	uc003eug.1,p.L268F|NM_001679,p.L268F|ENST00000286371,p.L268F|ENST00000462082,p.L78F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eug.1	nonsynonymous SNV	exon7	c.G804C	p.L268F	ANLKSQDDRDKFLGRVMFKITARA	ANLKSQDDRDKFFGRVMFKITARA	10.0	10.0	-	-	4126_3:141644507-141644507 G>C_ANLKSQDDRDKFFGRVMFKITARA	0.0
X:89177518-89177518 A>C	0.0	4278	COLORECTAL	-	-	-	-	TGIF2LX	uc022bzr.1,p.K145T|uc004efe.3,p.K145T|NM_138960,p.K145T|ENST00000283891,p.K145T|ENST00000561129,p.K145T	protein_coding	uc022bzr.1	nonsynonymous SNV	exon1	c.A434C	p.K145T	THLQSTEASVPAKSGPSGPDNVQSL	THLQSTEASVPATSGPSGPDNVQSL	1.0	7.0	-	-	4278_X:89177518-89177518 A>C_THLQSTEASVPATSGPSGPDNVQSL	0.0
14:51464776-51464776 G>A	0.0	4346	COLORECTAL	-	-	-	-	TRIM9	ENST00000360392,p.T532M|NM_052978,p.T532M|uc001wyz.4,p.T532M	retained_intron, protein_coding, processed_transcript	uc001wyz.4	nonsynonymous SNV	exon7	c.C1595T	p.T532M	GVSPYSKTLVLQTSEGKALQQYPSE	GVSPYSKTLVLQMSEGKALQQYPSE	3.0	1.0	-	-	4346_14:51464776-51464776 G>A_GVSPYSKTLVLQMSEGKALQQYPSE	0.0
11:6530417-6530417 G>A	0.0	2591	MELANOMA	-	-	-	-	DNHD1	ENST00000527990,p.G384R|ENST00000354685,p.G384R|uc001mdq.3,p.G73R|uc001mdw.4,p.G384R|NM_173589,p.G384R|NM_144666,p.G384R|ENST00000254579,p.G384R|uc001mdp.3,p.G384R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001mdw.4	nonsynonymous SNV	exon6	c.G1150A	p.G384R	SFTCWKKNVRLQGLHRLQKFLENHL	SFTCWKKNVRLQRLHRLQKFLENHL	3.0	5.0	-	-	2591_11:6530417-6530417 G>A_SFTCWKKNVRLQRLHRLQKFLENHL	0.0
12:123072294-123072294 C>T	0.0	4134	NSCLC	-	-	-	-	KNTC1	ENST00000333479,p.S1256F|NM_014708,p.S1256F|uc001ucv.3,p.S1256F	retained_intron, protein_coding, processed_transcript	uc001ucv.3	nonsynonymous SNV	exon39	c.C3767T	p.S1256F	GDGLVLPVINSISALLQNLQESSQW	GDGLVLPVINSIFALLQNLQESSQW	9.0	2.0	-	-	4134_12:123072294-123072294 C>T_GDGLVLPVINSIFALLQNLQESSQW	0.0
2:179597700-179597700 G>T	0.0	4095	COLORECTAL	-	-	-	-	TTN	uc031rqd.1,p.D5084E|NM_133378,p.D4157E|uc002umz.1,p.D818E|ENST00000342992,p.D4157E|ENST00000591111,p.D5084E|NM_001267550,p.D5401E|ENST00000589042,p.D5401E|NM_001256850,p.D5084E|uc021vsy.2,p.D4157E|uc031rqc.1,p.D5401E	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon53	c.C15252A	p.D5084E	SWFKDGKEIAASDRYRIAFVEGTAS	SWFKDGKEIAASERYRIAFVEGTAS	6.0	8.0	-	-	4095_2:179597700-179597700 G>T_SWFKDGKEIAASERYRIAFVEGTAS	0.0
3:118935103-118935103 C>T	1.0	4345	COLORECTAL	-	-	-	-	B4GALT4	uc003eci.3,p.E296K|NM_212543,p.E296K|ENST00000359213,p.E296K|uc003ech.3,p.E296K|NM_003778,p.E296K|ENST00000393765,p.E296K|ENST00000483209,p.E296K|uc003ecg.3,p.E296K	protein_coding, processed_transcript, nonsense_mediated_decay	uc003eci.3	nonsynonymous SNV	exon7	c.G886A	p.E296K	YTMVFHTRDKGNEVNAERMKLLHQV	YTMVFHTRDKGNKVNAERMKLLHQV	7.0	10.0	-	-	4345_3:118935103-118935103 C>T_YTMVFHTRDKGNKVNAERMKLLHQV	0.0
22:31846339-31846339 A>G	0.0	4317	COLORECTAL	-	-	-	-	EIF4ENIF1	NM_019843,p.L507P|ENST00000330125,p.L507P|uc003akz.2,p.L507P|uc003ala.2,p.L507P|ENST00000418321,p.L105P|uc003aky.2,p.L186P|NM_001164501,p.L507P|ENST00000397525,p.L507P	retained_intron, protein_coding, nonsense_mediated_decay	uc003ala.2	nonsynonymous SNV	exon11	c.T1520C	p.L507P	GTLPSQPKVSRNLESHLMSPAEIPG	GTLPSQPKVSRNPESHLMSPAEIPG	8.0	3.0	-	-	4317_22:31846339-31846339 A>G_GTLPSQPKVSRNPESHLMSPAEIPG	0.0
2:71017739-71017739 C>T	0.0	4213	COLORECTAL	-	-	-	-	FIGLA	NM_001004311,p.R11H|ENST00000332372,p.R11H|uc002she.1,p.R11H	protein_coding	uc002she.1	nonsynonymous SNV	exon1	c.G32A	p.R11H	MDPAPGVLDPRAAPPALLGTPQA	MDPAPGVLDPHAAPPALLGTPQA	3.0	8.0	-	-	4213_2:71017739-71017739 C>T_MDPAPGVLDPHAAPPALLGTPQA	0.0
9:140086742-140086742 C>A	1.0	4234	NSCLC	-	-	-	-	TPRN	uc004clt.3,p.R681M|ENST00000321773,p.R620M|ENST00000333046,p.R479M	retained_intron, protein_coding, processed_transcript	uc004clt.3	nonsynonymous SNV	exon3	c.G2042T	p.R681M	SKWQEQALEQAPREAEPPPVEAMVR	SKWQEQALEQAPMEAEPPPVEAMVR	8.0	3.0	-	-	4234_9:140086742-140086742 C>A_SKWQEQALEQAPMEAEPPPVEAMVR	0.0
7:92761222-92761222 T>C	1.0	3903	MELANOMA	-	-	-	-	SAMD9L	uc003umh.1,p.T1355A|uc022ahh.1,p.T1355A|uc003umi.1,p.T1355A|uc010lfd.1,p.T1355A|uc003umj.1,p.T1355A|ENST00000437805,p.T1355A|uc003umk.1,p.T1355A|ENST00000318238,p.T1355A|uc010lfb.1,p.T1355A|NM_152703,p.T1355A|uc010lfc.1,p.T1355A|ENST00000411955,p.T1355A	protein_coding, processed_transcript	uc022ahh.1	nonsynonymous SNV	exon1	c.A4063G	p.T1355A	LLEYLNPNYKDATTMESIVNEYAFL	LLEYLNPNYKDAATMESIVNEYAFL	8.0	4.0	-	-	3903_7:92761222-92761222 T>C_LLEYLNPNYKDAATMESIVNEYAFL	0.0
12:50589640-50589640 G>A	1.0	3713	MELANOMA	-	-	-	-	LIMA1	ENST00000552720,p.R335C|ENST00000341247,p.R335C|NM_001243775,p.R33C|ENST00000552823,p.R175C|uc001rwj.4,p.R335C|ENST00000552491,p.R33C|uc001rwg.4,p.R33C|ENST00000552909,p.R175C|uc001rwh.4,p.R175C|NM_016357,p.R335C|ENST00000547825,p.R33C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rwj.4	nonsynonymous SNV	exon8	c.C1003T	p.R335C	EKISANENSLAVRSTPAEDDSRDSQ	EKISANENSLAVCSTPAEDDSRDSQ	10.0	10.0	-	-	3713_12:50589640-50589640 G>A_EKISANENSLAVCSTPAEDDSRDSQ	0.0
16:22237253-22237253 G>T	1.0	4234	NSCLC	-	-	-	-	EEF2K	ENST00000263026,p.R68L|ENST00000568269,p.R68L|uc002dki.3,p.R68L|NM_013302,p.R68L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dki.3	nonsynonymous SNV	exon2	c.G203T	p.R68L	VNKYYSNLTKSERYSSSGSPANSFH	VNKYYSNLTKSELYSSSGSPANSFH	8.0	10.0	-	-	4234_16:22237253-22237253 G>T_VNKYYSNLTKSELYSSSGSPANSFH	0.0
17:1840152-1840152 C>T	0.0	4245	COLORECTAL	-	-	-	-	RTN4RL1	uc002ftp.3,p.D322N|ENST00000331238,p.D322N|NM_178568,p.D322N	protein_coding	uc002ftp.3	nonsynonymous SNV	exon2	c.G964A	p.D322N	PHQIKSHTLTTTDRAARKEHHSPHG	PHQIKSHTLTTTNRAARKEHHSPHG	4.0	5.0	-	-	4245_17:1840152-1840152 C>T_PHQIKSHTLTTTNRAARKEHHSPHG	0.0
19:6733003-6733003 G>A	1.0	3713	MELANOMA	-	-	-	-	GPR108	ENST00000430424,p.H68Y|NM_001080452,p.H310Y|uc002mfp.3,p.H310Y|ENST00000264080,p.H310Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002mfp.3	nonsynonymous SNV	exon10	c.C928T	p.H310Y	ALAFTKSISLLFHSINYYFINSQGH	ALAFTKSISLLFYSINYYFINSQGH	8.0	8.0	-	-	3713_19:6733003-6733003 G>A_ALAFTKSISLLFYSINYYFINSQGH	0.0
6:136687137-136687137 G>A	0.0	4155	MELANOMA	-	-	-	-	MAP7	ENST00000544465,p.P322S|uc010kgv.3,p.P359S|NM_001198615,p.P322S|ENST00000354570,p.P337S|uc010kgq.2,p.P243S|uc011edh.2,p.P322S|NM_001198619,p.P191S|NM_001198609,p.P367S|ENST00000454590,p.P359S|NM_001198617,p.P243S|NM_001198616,p.P300S|NM_001198614,p.P359S|uc011edi.2,p.P191S|uc010kgr.2,p.P191S|NM_001198608,p.P359S|NM_003980,p.P337S|uc003qha.2,p.P300S|uc011edg.2,p.P367S|uc010kgs.3,p.P191S|uc003qgz.3,p.P337S|NM_001198618,p.P191S|ENST00000432797,p.P191S|uc011edf.2,p.P322S|uc010kgu.3,p.P359S|NM_001198611,p.P322S|ENST00000438100,p.P322S	protein_coding	uc011edi.2	nonsynonymous SNV	exon10	c.C571T	p.P191S	ARSRLWLPSKSLPHLPGTPRPTSSL	ARSRLWLPSKSLSHLPGTPRPTSSL	3.0	7.0	-	-	4155_6:136687137-136687137 G>A_ARSRLWLPSKSLSHLPGTPRPTSSL	0.0
11:113264247-113264247 A>C	1.0	4245	COLORECTAL	-	-	-	-	ANKK1	ENST00000303941,p.K77T|uc001pny.3,p.K77T|NM_178510,p.K77T	protein_coding, nonsense_mediated_decay	uc001pny.3	nonsynonymous SNV	exon2	c.A230C	p.K77T	VNYLIEEAAKMKKIKFQHIVSIYGV	VNYLIEEAAKMKTIKFQHIVSIYGV	3.0	2.0	-	-	4245_11:113264247-113264247 A>C_VNYLIEEAAKMKTIKFQHIVSIYGV	0.0
15:55839065-55839065 C>T	0.0	4329	COLORECTAL	-	-	-	-	PYGO1	ENST00000563719,p.G139D|NM_015617,p.G139D|uc002adf.1,p.G139D|uc010bfl.1,p.G139D|ENST00000302000,p.G139D	protein_coding	uc010bfl.1	nonsynonymous SNV	exon3	c.G416A	p.G139D	QPHPFPQNPLGMGFNRPHAFNFGPH	QPHPFPQNPLGMDFNRPHAFNFGPH	2.0	7.0	-	-	4329_15:55839065-55839065 C>T_QPHPFPQNPLGMDFNRPHAFNFGPH	0.0
3:45812818-45812818 C>T	1.0	4196	COLORECTAL	-	-	ID=COSM189397,COSM189398;OCCURENCE=1(central_nervous_system),1(large_intestine)	-	SLC6A20	ENST00000358525,p.A276T|NM_020208,p.A276T|uc011baj.2,p.A239T|uc011bai.2,p.A276T|ENST00000353278,p.A239T|NM_022405,p.A239T|ENST00000413781,p.A229T|ENST00000456124,p.A276T	retained_intron, protein_coding, processed_transcript	uc011baj.2	nonsynonymous SNV	exon5	c.G715A	p.A239T	SYNEPSNNCQKHAIIVSLINSFTSI	SYNEPSNNCQKHTIIVSLINSFTSI	8.0	8.0	-	-	4196_3:45812818-45812818 C>T_SYNEPSNNCQKHTIIVSLINSFTSI	0.0
X:135498630-135498630 C>T	0.0	3998	MELANOMA	-	-	-	-	GPR112	ENST00000394143,p.P3075S|ENST00000412101,p.P2870S|ENST00000370652,p.P3075S|NM_153834,p.P3075S|uc004ezu.1,p.P3075S|ENST00000394141,p.P2870S|uc010nsb.1,p.P2870S	protein_coding	uc010nsb.1	nonsynonymous SNV	exon23	c.C8608T	p.P2870S	EISFPNDDFDKDPYCSSP	EISFPNDDFDKDSYCSSP	1.0	10.0	-	-	3998_X:135498630-135498630 C>T_EISFPNDDFDKDSYCSSP	0.0
22:26868361-26868361 G>T	1.0	3775	CERVICAL	-	-	-	-	HPS4	uc003aci.4,p.S131R|ENST00000398141,p.S131R|uc010gvd.2,p.S136R|ENST00000439453,p.S136R|NM_022081,p.S136R|ENST00000402105,p.S131R|uc003acl.4,p.S136R|ENST00000464362,p.S131R|ENST00000336873,p.S136R|NM_152841,p.S131R|ENST00000429411,p.S131R|ENST00000398145,p.S136R|ENST00000422379,p.S136R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010gvd.2	nonsynonymous SNV	exon6	c.C408A	p.S136R	SLAYENCSQEELSTEWDTFIEQILK	SLAYENCSQEELRTEWDTFIEQILK	9.0	8.0	-	-	3775_22:26868361-26868361 G>T_SLAYENCSQEELRTEWDTFIEQILK	0.0
2:85012801-85012801 C>T	0.0	4155	MELANOMA	-	-	-	-	DNAH6	ENST00000237449,p.S3674L|NM_001370,p.S3674L|uc010fgb.3,p.S3674L|uc002sot.3,p.S433L|ENST00000389394,p.S3674L	retained_intron, protein_coding, processed_transcript	uc010fgb.3	nonsynonymous SNV	exon67	c.C11021T	p.S3674L	ANIRRAFTEMTPSFFEENILGKKWR	ANIRRAFTEMTPLFFEENILGKKWR	3.0	8.0	-	-	4155_2:85012801-85012801 C>T_ANIRRAFTEMTPLFFEENILGKKWR	0.0
3:130799378-130799378 C>G	1.0	4078	GASTRIC	-	-	-	-	NEK11	ENST00000429253,p.F94L|uc003eoa.3,p.F94L|ENST00000511262,p.F94L|uc003enw.1,p.F94L|ENST00000510769,p.F94L|uc011blm.2,p.F94L|uc003enx.3,p.F94L|ENST00000514915,p.F94L|NM_024800,p.F94L|NM_145910,p.F94L|ENST00000510688,p.F94L|ENST00000508196,p.F94L|ENST00000383366,p.F94L|uc011bll.2,p.F94L|ENST00000356918,p.F94L|ENST00000507910,p.F94L|NM_001146003,p.F94L|uc003eny.3,p.F94L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011blm.2	nonsynonymous SNV	exon3	c.C282G	p.F94L	LLSKLDHPAIVKFHASFVEQDNFCI	LLSKLDHPAIVKLHASFVEQDNFCI	5.0	3.0	-	-	4078_3:130799378-130799378 C>G_LLSKLDHPAIVKLHASFVEQDNFCI	0.0
15:36936509-36936509 C>A	1.0	4266	COLORECTAL	-	-	-	-	C15orf41	uc001zje.4,p.F44L|ENST00000437989,p.F44L|NM_001290233,p.F44L|ENST00000566621,p.F44L|ENST00000569302,p.F44L|NM_001130010,p.F44L	retained_intron, protein_coding, processed_transcript	uc001zje.4	nonsynonymous SNV	exon2	c.C132A	p.F44L	FPSQSQATLLSIFSQEYQKHIKRTH	FPSQSQATLLSILSQEYQKHIKRTH	5.0	2.0	-	-	4266_15:36936509-36936509 C>A_FPSQSQATLLSILSQEYQKHIKRTH	0.0
X:109931893-109931893 C>T	0.0	3998	MELANOMA	-	-	-	-	CHRDL1	uc010nps.3,p.R305Q|NM_001143981,p.R306Q|ENST00000372042,p.R306Q|NM_145234,p.R305Q|ENST00000394797,p.R305Q|ENST00000372045,p.R299Q|ENST00000444321,p.R305Q|ENST00000434224,p.R226Q|uc004eow.3,p.R305Q|uc011mss.2,p.R226Q|uc004eou.4,p.R306Q|uc004eov.3,p.R300Q|NM_001143983,p.R226Q|ENST00000482160,p.R226Q|ENST00000218054,p.R305Q|NM_001143982,p.R305Q	protein_coding	uc011mss.2	nonsynonymous SNV	exon7	c.G677A	p.R226Q	TKQECKKIHCPNRYPCKYPQKIDGK	TKQECKKIHCPNQYPCKYPQKIDGK	1.0	10.0	-	-	3998_X:109931893-109931893 C>T_TKQECKKIHCPNQYPCKYPQKIDGK	0.0
10:13337502-13337502 C>T	1.0	4335	COLORECTAL	-	-	-	-	PHYH	NM_006214,p.R80H|ENST00000396920,p.R61H|ENST00000263038,p.R80H|uc001imf.3,p.R80H|ENST00000479604,p.R80H	retained_intron, protein_coding	uc001imf.3	nonsynonymous SNV	exon3	c.G239A	p.R80H	VIKNLVPDADIQRFRNEFEKICRKE	VIKNLVPDADIQHFRNEFEKICRKE	8.0	7.0	-	-	4335_10:13337502-13337502 C>T_VIKNLVPDADIQHFRNEFEKICRKE	0.0
2:145155967-145155967 C>T	0.0	4134	NSCLC	-	-	-	-	ZEB2	ENST00000558170,p.M929I|ENST00000409487,p.M929I|uc010zbm.2,p.M905I|ENST00000303660,p.M929I|ENST00000539609,p.M905I|uc010fnq.1,p.M958I|uc002tvv.3,p.M923I|NM_014795,p.M929I|NM_001171653,p.M905I|uc002tvu.3,p.M929I	retained_intron, protein_coding, processed_transcript	uc010zbm.2	nonsynonymous SNV	exon7	c.G2715A	p.M905I	IPGLRPYPGLDQMSFLPHMAYTYPT	IPGLRPYPGLDQISFLPHMAYTYPT	7.0	3.0	-	-	4134_2:145155967-145155967 C>T_IPGLRPYPGLDQISFLPHMAYTYPT	0.0
3:185195115-185195115 G>C	1.0	3713	MELANOMA	-	-	-	1	MAP3K13	uc010hyg.3,p.S501T|NM_001242314,p.S811T|NM_004721,p.S811T|uc010hyf.3,p.S811T|ENST00000443863,p.S667T|ENST00000535426,p.S667T|ENST00000265026,p.S811T|ENST00000424227,p.S811T|uc011brt.2,p.S604T|ENST00000446828,p.S604T|uc003fpi.3,p.S811T|NM_001242317,p.S604T|uc011bru.2,p.S667T	retained_intron, protein_coding, nonsense_mediated_decay	uc011bru.2	nonsynonymous SNV	exon12	c.G2000C	p.S667T	PALPRKTRPLQKSGDDSSEEEEGEV	PALPRKTRPLQKTGDDSSEEEEGEV	9.0	7.0	-	-	3713_3:185195115-185195115 G>C_PALPRKTRPLQKTGDDSSEEEEGEV	0.0
7:140285423-140285423 G>A	1.0	3713	MELANOMA	-	-	-	-	DENND2A	ENST00000461883,p.S404F|uc010lnj.3,p.S404F|uc003vvw.3,p.S404F|ENST00000537639,p.S404F|uc003vvx.3,p.S404F|ENST00000275884,p.S404F|ENST00000492720,p.S404F|uc010lnk.3,p.S404F|ENST00000475837,p.S27F|ENST00000496613,p.S404F|NM_015689,p.S404F	protein_coding, nonsense_mediated_decay	uc010lnk.3	nonsynonymous SNV	exon5	c.C1211T	p.S404F	CLGKKCVLNFPASPTSSIPDTLTKQ	CLGKKCVLNFPAFPTSSIPDTLTKQ	4.0	5.0	-	-	3713_7:140285423-140285423 G>A_CLGKKCVLNFPAFPTSSIPDTLTKQ	0.0
2:96690298-96690298 C>T	0.0	4316	COLORECTAL	-	-	-	-	GPAT2	uc002svg.3,p.V395M|ENST00000359548,p.V516M|uc002sve.3,p.V318M|ENST00000453542,p.V445M|NM_207328,p.V516M|uc010yuh.2,p.V445M|ENST00000434632,p.V516M|uc002svh.3,p.V516M|ENST00000377137,p.V516M|uc002svf.3,p.V516M|uc002svd.3,p.V335M	retained_intron, protein_coding, processed_transcript	uc010yuh.2	nonsynonymous SNV	exon14	c.G1333A	p.V445M	LLQHSLSLLRAHVALLRIRQGDLLV	LLQHSLSLLRAHMALLRIRQGDLLV	2.0	8.0	-	-	4316_2:96690298-96690298 C>T_LLQHSLSLLRAHMALLRIRQGDLLV	0.0
14:36041924-36041924 A>C	0.0	4317	COLORECTAL	-	-	-	-	RALGAPA1	ENST00000258840,p.L1945V|NM_001283043,p.L1911V|ENST00000389698,p.L1898V|ENST00000553892,p.L1945V|NM_194301,p.L1898V|uc001wti.3,p.L1898V|NM_014990,p.L1898V|ENST00000382366,p.L1911V|NM_001283044,p.L1945V|ENST00000307138,p.L1898V|uc010tpw.1,p.L1945V|uc010tpv.2,p.L1911V|ENST00000554259,p.L536V|uc001wtj.3,p.L1898V	retained_intron, protein_coding, processed_transcript	uc010tpw.1	nonsynonymous SNV	exon38	c.T5833G	p.L1945V	MPSDSDDSLTKKLRHLGNDEVHIVW	MPSDSDDSLTKKVRHLGNDEVHIVW	8.0	2.0	-	-	4317_14:36041924-36041924 A>C_MPSDSDDSLTKKVRHLGNDEVHIVW	0.0
6:152265335-152265335 G>C	0.0	4186	BREAST	-	-	-	1	ESR1	NM_001122740,p.R263T|uc003qom.4,p.R263T|NM_001122742,p.R263T|uc010kio.3,p.R265T|uc011eex.2,p.R44T|uc003qoo.4,p.R263T|ENST00000440973,p.R263T|uc010kin.3,p.R263T|ENST00000338799,p.R263T|ENST00000544394,p.R90T|ENST00000206249,p.R263T|uc003qon.4,p.R263T|NM_001122741,p.R263T|NM_000125,p.R263T|ENST00000443427,p.R263T|NM_001291230,p.R265T	protein_coding, processed_transcript	uc011eex.2	nonsynonymous SNV	exon2	c.G131C	p.R44T	MKGGIRKDRRGGRMLKHKRQRDDGE	MKGGIRKDRRGGTMLKHKRQRDDGE	3.0	9.0	-	-	4186_6:152265335-152265335 G>C_MKGGIRKDRRGGTMLKHKRQRDDGE	0.0
12:420076-420076 T>G	1.0	4335	COLORECTAL	-	-	-	1	KDM5A	uc010sdn.1,p.K1023T|NM_001042603,p.K1064T|uc001qif.1,p.K1064T|ENST00000382815,p.K1064T|ENST00000399788,p.K1064T|ENST00000544760,p.K683T	retained_intron, protein_coding, processed_transcript	uc010sdn.1	nonsynonymous SNV	exon20	c.A3068C	p.K1023T	AWRERTGRTFLKKNSSHTLLQVLSP	AWRERTGRTFLKTNSSHTLLQVLSP	9.0	2.0	-	-	4335_12:420076-420076 T>G_AWRERTGRTFLKTNSSHTLLQVLSP	0.0
4:6865157-6865157 C>G	0.0	3775	CERVICAL	-	-	-	-	KIAA0232	NM_014743,p.I1016M|ENST00000307659,p.I1016M|NM_001100590,p.I1016M|ENST00000425103,p.I1016M|uc003gjr.4,p.I1016M|uc003gjq.4,p.I1016M	protein_coding, processed_transcript	uc003gjr.4	nonsynonymous SNV	exon7	c.C3048G	p.I1016M	SGENGLNKGFSFIFHEDLLGACGNF	SGENGLNKGFSFMFHEDLLGACGNF	6.0	3.0	-	-	3775_4:6865157-6865157 C>G_SGENGLNKGFSFMFHEDLLGACGNF	0.0
X:102318048-102318048 C>T	0.0	4235	COLORECTAL	-	-	-	-	BEX1	uc004ejt.1,p.R52Q|NM_018476,p.R52Q|ENST00000372728,p.R52Q|uc022cbj.1,p.R52Q	protein_coding	uc022cbj.1	nonsynonymous SNV	exon1	c.G155A	p.R52Q	AGEYCVPRGNRRRFRVRQPILQYRW	AGEYCVPRGNRRQFRVRQPILQYRW	2.0	9.0	-	-	4235_X:102318048-102318048 C>T_AGEYCVPRGNRRQFRVRQPILQYRW	0.0
4:134084204-134084204 C>A	0.0	4110	BILE DUCT	-	-	-	-	PCDH10	NM_032961,p.S957Y|uc003iha.3,p.S957Y|ENST00000264360,p.S957Y	retained_intron, protein_coding	uc003iha.3	nonsynonymous SNV	exon4	c.C2870A	p.S957Y	KALGHSDRCWMPSFVPSDGRQAADY	KALGHSDRCWMPYFVPSDGRQAADY	1.0	9.0	-	-	4110_4:134084204-134084204 C>A_KALGHSDRCWMPYFVPSDGRQAADY	0.0
12:53242482-53242482 C>T	0.0	4284	COLORECTAL	-	-	-	-	KRT78	ENST00000304620,p.C78Y|NM_173352,p.C78Y|uc001sbc.1,p.C78Y	retained_intron, protein_coding	uc001sbc.1	nonsynonymous SNV	exon1	c.G233A	p.C78Y	FGEWSGGPGLSLCPPGGIQEVTINQ	FGEWSGGPGLSLYPPGGIQEVTINQ	1.0	4.0	-	-	4284_12:53242482-53242482 C>T_FGEWSGGPGLSLYPPGGIQEVTINQ	0.0
16:31437411-31437411 G>A	0.0	4189	MELANOMA	-	-	-	-	ITGAD	ENST00000389202,p.D1150N|uc010cap.1,p.D1151N|uc002ebv.1,p.D1150N|NM_005353,p.D1150N	retained_intron, protein_coding	uc010cap.1	nonsynonymous SNV	exon30	c.G3451A	p.D1151N	DKPEDTATFSGDDFSCVAPNVPLS	DKPEDTATFSGDNFSCVAPNVPLS	1.0	5.0	-	-	4189_16:31437411-31437411 G>A_DKPEDTATFSGDNFSCVAPNVPLS	0.0
19:5208383-5208383 A>T	0.0	4245	COLORECTAL	-	-	-	-	PTPRS	ENST00000588012,p.V1798D|ENST00000372412,p.V1837D|ENST00000353284,p.V1389D|uc010xin.2,p.V1378D|NM_130853,p.V1389D|uc002mbx.3,p.V1393D|uc002mbw.3,p.V1798D|ENST00000592099,p.V1389D|NM_002850,p.V1836D|uc002mby.3,p.V1389D|uc002mbu.1,p.V1405D|ENST00000357368,p.V1836D|ENST00000262963,p.V1816D|uc002mbv.3,p.V1836D|ENST00000587303,p.V1836D|ENST00000348075,p.V1798D|NM_130855,p.V1393D|NM_130854,p.V1798D	retained_intron, protein_coding, processed_transcript	uc010xin.2	nonsynonymous SNV	exon26	c.T4133A	p.V1378D	KVTDARDGQSRTVRQFQFTDWPEQG	KVTDARDGQSRTDRQFQFTDWPEQG	5.0	7.0	-	-	4245_19:5208383-5208383 A>T_KVTDARDGQSRTDRQFQFTDWPEQG	0.0
16:48230197-48230197 C>G	0.0	3775	CERVICAL	-	-	-	-	ABCC11	uc002efh.1,p.E784Q|ENST00000356608,p.E784Q|uc002eff.1,p.E784Q|ENST00000394748,p.E784Q|uc002efg.1,p.E784Q|ENST00000394747,p.E784Q|NM_033151,p.E784Q|NM_032583,p.E784Q|NM_145186,p.E784Q|ENST00000353782,p.E784Q	retained_intron, protein_coding, processed_transcript	uc002efh.1	nonsynonymous SNV	exon18	c.G2350C	p.E784Q	VPEHQLTQEEEMEEGSLSWRVYHHY	VPEHQLTQEEEMQEGSLSWRVYHHY	2.0	10.0	-	-	3775_16:48230197-48230197 C>G_VPEHQLTQEEEMQEGSLSWRVYHHY	0.0
2:7030312-7030312 C>A	1.0	4095	COLORECTAL	-	-	-	-	RSAD2	ENST00000382040,p.F248L|NM_080657,p.F248L|uc002qyp.1,p.F248L|ENST00000541728,p.F141L	retained_intron, protein_coding, processed_transcript	uc002qyp.1	nonsynonymous SNV	exon4	c.C744A	p.F248L	QIKALNPVRWKVFQCLLIEGENCGE	QIKALNPVRWKVLQCLLIEGENCGE	8.0	9.0	-	-	4095_2:7030312-7030312 C>A_QIKALNPVRWKVLQCLLIEGENCGE	0.0
7:45115547-45115547 C>G	1.0	3713	MELANOMA	-	-	-	-	CCM2	NM_001167934,p.S351C|ENST00000258781,p.S409C|ENST00000475551,p.S403C|ENST00000474617,p.S312C|uc003tmp.3,p.S351C|uc003tms.3,p.S430C|NM_001029835,p.S430C|ENST00000544363,p.S318C|ENST00000541586,p.S351C|uc003tmr.3,p.S318C|ENST00000381112,p.S430C|NM_001167935,p.S318C|NM_031443,p.S409C|uc003tmo.3,p.S409C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003tms.3	nonsynonymous SNV	exon10	c.C1289G	p.S430C	SSTTNGNRATGSSDDRSAPSEGDEW	SSTTNGNRATGSCDDRSAPSEGDEW	8.0	6.0	-	-	3713_7:45115547-45115547 C>G_SSTTNGNRATGSCDDRSAPSEGDEW	0.0
4:39863906-39863906 G>A, 4:39863926-39863926 T>A	1.0	3998	MELANOMA	-	-	-	-	PDS5A	uc003guv.4,p.H1007Y|ENST00000303538,p.H1007Y|NM_001100399,p.H1007Y	retained_intron, protein_coding, nonsense_mediated_decay	uc003guv.4	nonsynonymous SNV	exon26	c.C3019T, c.A2999T 	p.Y1000F, p.H1007Y	SLLPEYVVPYMIHLLAHDPDFTRSQ	SLLPEFVVPYMIYLLAHDPDFTRSQ	9.0	8.0	CD8	snv,snv PR	3998_4:39863906-39863906 G>A, 4:39863926-39863926 T>A_SLLPEFVVPYMIYLLAHDPDFTRSQ	1.0
19:2227019-2227019 C>G	1.0	4252	COLORECTAL	-	-	-	-	DOT1L	NM_032482,p.S1500C|ENST00000446286,p.S35C|ENST00000398665,p.S1500C|uc002lvc.1,p.S794C|uc002lvb.4,p.S1500C|ENST00000457590,p.S380C	retained_intron, protein_coding, processed_transcript	uc002lvc.1	nonsynonymous SNV	exon13	c.C2381G	p.S794C	VAGSSVLQSLFSSVPAAAGLVHVSS	VAGSSVLQSLFSCVPAAAGLVHVSS	7.0	6.0	-	-	4252_19:2227019-2227019 C>G_VAGSSVLQSLFSCVPAAAGLVHVSS	0.0
20:61511172-61511172 G>A	1.0	3713	MELANOMA	-	-	-	-	DIDO1	uc002ydr.2,p.P2046S|ENST00000266070,p.P2046S|ENST00000395343,p.P2046S|uc002yds.2,p.P2046S|NM_033081,p.P2046S|NM_001193369,p.P2046S	protein_coding	uc002yds.2	nonsynonymous SNV	exon16	c.C6136T	p.P2046S	PQHRKDRWEEAGPPSALSSSAPGQG	PQHRKDRWEEAGSPSALSSSAPGQG	9.0	9.0	-	-	3713_20:61511172-61511172 G>A_PQHRKDRWEEAGSPSALSSSAPGQG	0.0
17:48148792-48148792 G>C	1.0	3775	CERVICAL	-	-	-	-	ITGA3	ENST00000320031,p.G290A|uc010dbm.3,p.G290A|ENST00000007722,p.G290A|NM_002204,p.G290A|ENST00000544892,p.G65A|NM_005501,p.G290A|uc010dbl.3,p.G290A	retained_intron, protein_coding, nonsense_mediated_decay	uc010dbm.3	nonsynonymous SNV	exon6	c.G869C	p.G290A	MGAVFLLSQEAGGDLRRRQVLEGSQ	MGAVFLLSQEAGADLRRRQVLEGSQ	8.0	6.0	-	-	3775_17:48148792-48148792 G>C_MGAVFLLSQEAGADLRRRQVLEGSQ	0.0
7:42007382-42007382 G>A	0.0	4246	COLORECTAL	-	-	-	-	GLI3	ENST00000395925,p.P748L|uc011kbh.2,p.P748L|uc011kbg.2,p.P689L|NM_000168,p.P748L	retained_intron, protein_coding, processed_transcript	uc011kbh.2	nonsynonymous SNV	exon14	c.C2243T	p.P748L	GSIGDLSAIDETPIMDSTISTATTA	GSIGDLSAIDETLIMDSTISTATTA	2.0	1.0	-	-	4246_7:42007382-42007382 G>A_GSIGDLSAIDETLIMDSTISTATTA	0.0
4:108817031-108817031 G>A	0.0	2359	MELANOMA	-	-	-	-	SGMS2	ENST00000394684,p.E108K|NM_001136258,p.E108K|NM_001136257,p.E108K|uc003hyn.3,p.E108K|NM_152621,p.E108K|uc003hyo.3,p.E108K|uc003hyl.4,p.E108K|ENST00000394686,p.E108K|ENST00000359079,p.E108K	protein_coding, processed_transcript	uc003hyo.3	nonsynonymous SNV	exon2	c.G322A	p.E108K	MITVVHERVPPKELSPPLPDKFFDY	MITVVHERVPPKKLSPPLPDKFFDY	5.0	5.0	-	-	2359_4:108817031-108817031 G>A_MITVVHERVPPKKLSPPLPDKFFDY	0.0
2:136481699-136481699 C>T	1.0	3919	MELANOMA	-	-	-	-	R3HDM1	uc002tup.3,p.P991L|ENST00000410054,p.P991L|uc002tuo.3,p.P1046L|NM_001282798,p.P1047L|uc010zbh.2,p.P794L|ENST00000409606,p.P1047L|NM_015361,p.P1046L|NM_001282799,p.P918L|ENST00000409478,p.P918L|ENST00000329971,p.P917L|uc010fni.3,p.P1045L|ENST00000264160,p.P1046L|NM_001282800,p.P991L	retained_intron, protein_coding, processed_transcript	uc010zbh.2	nonsynonymous SNV	exon18	c.C2381T	p.P794L	SGDNTANPERSKPSDLASTYTVLAT	SGDNTANPERSKLSDLASTYTVLAT	8.0	4.0	-	-	3919_2:136481699-136481699 C>T_SGDNTANPERSKLSDLASTYTVLAT	0.0
16:14859053-14859053 T>A	0.0	4316	COLORECTAL	-	-	-	-	NPIPA2,NPIPA3	NM_001277324,p.L279Q|uc002dct.4,p.L279Q|ENST00000529166,p.L298Q|ENST00000553201,p.L279Q|NM_001277323,p.L279Q	protein_coding	uc002dct.4	nonsynonymous SNV	exon8	c.T836A	p.L279Q	PECLLTPLPPSALPSADDNLKTPAE	PECLLTPLPPSAQPSADDNLKTPAE	10.0	4.0	-	-	4316_16:14859053-14859053 T>A_PECLLTPLPPSAQPSADDNLKTPAE	0.0
19:33792530-33792530 C>T	0.0	3903	MELANOMA	-	-	-	1	CEBPA	uc002nun.3,p.R264H|NM_001287435,p.R250H|ENST00000498907,p.R264H|NM_004364,p.R264H|NM_001287424,p.R299H|NM_001285829,p.R145H	protein_coding	uc002nun.3	nonsynonymous SNV	exon1	c.G791A	p.R264H	ALKGLGAAHPDLRASGGSGAGKAKK	ALKGLGAAHPDLHASGGSGAGKAKK	5.0	4.0	-	-	3903_19:33792530-33792530 C>T_ALKGLGAAHPDLHASGGSGAGKAKK	0.0
2:183053753-183053753 G>A	1.0	3903	MELANOMA	-	-	-	-	PDE1A	NM_001258313,p.S387F|ENST00000331935,p.S403F|ENST00000456212,p.S403F|NM_005019,p.S403F|ENST00000409365,p.S387F|ENST00000536095,p.S299F|ENST00000351439,p.S387F|ENST00000358139,p.S403F|uc010zfq.2,p.S407F|NM_001258314,p.S369F|uc002uou.4,p.S369F|ENST00000435564,p.S403F|ENST00000410103,p.S403F|NM_001003683,p.S403F|uc002uor.4,p.S387F|uc002uos.4,p.S403F|uc002uoq.2,p.S403F|NM_001258312,p.S407F|ENST00000346717,p.S369F|uc010zfp.2,p.S299F	protein_coding, processed_transcript	uc010zfq.2	nonsynonymous SNV	exon12	c.C1220T	p.S407F	QGDKEAELGLPFSPLCDRKSTMVAQ	QGDKEAELGLPFFPLCDRKSTMVAQ	7.0	4.0	-	-	3903_2:183053753-183053753 G>A_QGDKEAELGLPFFPLCDRKSTMVAQ	0.0
18:12449710-12449710 G>A	1.0	4259	COLORECTAL	-	-	ID=COSM285325,COSM285324;OCCURENCE=1(large_intestine)	-	SPIRE1	ENST00000409402,p.T733M|ENST00000453447,p.T599M|uc010wzw.2,p.T599M|uc010wzx.2,p.T522M|NM_001128626,p.T733M|uc010wzy.2,p.T719M|NM_020148,p.T719M|NM_001128627,p.T599M|uc002kre.3,p.T733M|ENST00000309836,p.T522M|ENST00000410092,p.T719M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wzy.2	nonsynonymous SNV	exon16	c.C2156T	p.T719M	VLANKRARLKRKTQSFYMSSPGPSE	VLANKRARLKRKMQSFYMSSPGPSE	7.0	10.0	-	-	4259_18:12449710-12449710 G>A_VLANKRARLKRKMQSFYMSSPGPSE	0.0
2:74884745-74884745 G>T	1.0	4252	COLORECTAL	-	-	-	-	SEMA4F	ENST00000339773,p.K117N|NM_001271661,p.K117N|uc002snc.2,p.K117N|ENST00000453930,p.K117N	protein_coding, processed_transcript, nonsense_mediated_decay	uc002snc.2	nonsynonymous SNV	exon3	c.G351T	p.K117N	PEAHRQNCRKKGKKEGDLGGRKTLQ	PEAHRQNCRKKGNKEGDLGGRKTLQ	6.0	7.0	-	-	4252_2:74884745-74884745 G>T_PEAHRQNCRKKGNKEGDLGGRKTLQ	0.0
16:1840750-1840750 C>T	1.0	4258	ENDOMETRIAL	-	-	-	-	IGFALS	NM_001146006,p.A595T|uc010uvn.2,p.A595T|ENST00000415638,p.A595T|uc010uvo.2,p.A191T|uc002cmy.3,p.A557T|ENST00000215539,p.A557T|NM_004970,p.A557T	protein_coding	uc010uvo.2	nonsynonymous SNV	exon2	c.G571A	p.A191T	KALRDFALQNPSAVPRFVQAICEGD	KALRDFALQNPSTVPRFVQAICEGD	4.0	8.0	-	-	4258_16:1840750-1840750 C>T_KALRDFALQNPSTVPRFVQAICEGD	0.0
13:92345524-92345524 G>A	0.0	3903	MELANOMA	-	-	-	-	GPC5	NM_004466,p.A137T|uc010tif.2,p.A137T|ENST00000377067,p.A137T	protein_coding, processed_transcript	uc010tif.2	nonsynonymous SNV	exon3	c.G409A	p.A137T	LFCSTYRNMALEAAASVQEFFTDVG	LFCSTYRNMALETAASVQEFFTDVG	1.0	7.0	-	-	3903_13:92345524-92345524 G>A_LFCSTYRNMALETAASVQEFFTDVG	0.0
6:30154120-30154120 C>G	1.0	4317	COLORECTAL	-	-	-	-	TRIM26	ENST00000454678,p.E385Q|uc003npr.3,p.E385Q|uc003npt.3,p.E385Q|uc003nps.3,p.E385Q|ENST00000437089,p.E385Q|uc010jry.3,p.E115Q|NM_001242783,p.E385Q|ENST00000453195,p.E385Q|NM_003449,p.E385Q	retained_intron, protein_coding, processed_transcript	uc010jry.3	nonsynonymous SNV	exon9	c.G343C	p.E115Q	EVEREGWSEDEEEGDEEEEGEEEEE	EVEREGWSEDEEQGDEEEEGEEEEE	8.0	2.0	-	-	4317_6:30154120-30154120 C>G_EVEREGWSEDEEQGDEEEEGEEEEE	0.0
12:51685901-51685901 G>A	0.0	3795	MELANOMA	-	-	-	-	BIN2	ENST00000604560,p.S303F|uc010sng.2,p.S304F|NM_001290008,p.S330F|uc009zlz.3,p.S298F|ENST00000267012,p.S330F|NM_016293,p.S362F|uc001ryg.3,p.S330F|NM_001290009,p.S206F|NM_001290007,p.S304F|ENST00000544402,p.S304F|uc001ryh.3,p.S206F|ENST00000452142,p.S298F	protein_coding	uc010sng.2	nonsynonymous SNV	exon10	c.C911T	p.S304F	EEEIEKEGSEASSSEEDEPLPACNG	EEEIEKEGSEASFSEEDEPLPACNG	5.0	10.0	-	-	3795_12:51685901-51685901 G>A_EEEIEKEGSEASFSEEDEPLPACNG	0.0
2:127808392-127808392 C>T	0.0	4155	MELANOMA	-	-	-	-	BIN1	uc010yzg.2,p.G397S|NM_139344,p.G477S|uc002tnx.2,p.G381S|NM_139346,p.G424S|NM_139348,p.G409S|uc002tns.2,p.G520S|uc002tnt.2,p.G336S|NM_139349,p.G402S|uc002tny.2,p.G433S|NM_139350,p.G366S|ENST00000346226,p.G445S|ENST00000259238,p.G424S|NM_139351,p.G336S|ENST00000376113,p.G351S|uc002toa.2,p.G409S|ENST00000393041,p.G402S|uc002tob.2,p.G366S|NM_139347,p.G445S|NM_139345,p.G433S|uc002tnv.2,p.G477S|ENST00000393040,p.G409S|uc002tnz.2,p.G445S|ENST00000352848,p.G381S|ENST00000351659,p.G433S|ENST00000316724,p.G520S|ENST00000409400,p.G366S|NM_004305,p.G381S|uc002tnw.2,p.G424S|uc010yzf.2,p.G312S|uc002toc.2,p.G402S|uc002tnu.2,p.G351S|NM_139343,p.G520S|ENST00000348750,p.G336S|ENST00000357970,p.G477S	retained_intron, protein_coding, processed_transcript	uc010yzg.2	nonsynonymous SNV	exon13	c.G1189A	p.G397S	GGSGAGRLDLPPGFMFKVQAQHDYT	GGSGAGRLDLPPSFMFKVQAQHDYT	6.0	5.0	-	-	4155_2:127808392-127808392 C>T_GGSGAGRLDLPPSFMFKVQAQHDYT	0.0
21:47850508-47850508 C>A	1.0	4158	COLORECTAL	-	-	-	-	PCNT	NM_006031,p.S2667R|ENST00000359568,p.S2667R|uc002zji.4,p.S2667R|uc002zjj.3,p.S2549R	retained_intron, protein_coding, processed_transcript	uc002zjj.3	nonsynonymous SNV	exon37	c.C7647A	p.S2549R	LESEQGKGRALQSQLEEEQLRHLQR	LESEQGKGRALQRQLEEEQLRHLQR	6.0	3.0	-	-	4158_21:47850508-47850508 C>A_LESEQGKGRALQRQLEEEQLRHLQR	0.0
19:3959233-3959233 G>A	0.0	4235	COLORECTAL	-	-	-	-	DAPK3	ENST00000301264,p.R411C|NM_001348,p.R411C|uc002lzd.1,p.R411C|uc002lzb.1,p.R148C|uc002lzc.1,p.R411C|ENST00000545797,p.R411C	retained_intron, protein_coding	uc002lzd.1	nonsynonymous SNV	exon9	c.C1231T	p.R411C	AKGALLGTSGLKRRFSRLENRYEAL	AKGALLGTSGLKCRFSRLENRYEAL	9.0	4.0	-	-	4235_19:3959233-3959233 G>A_AKGALLGTSGLKCRFSRLENRYEAL	0.0
7:24747822-24747822 G>A	0.0	3713	MELANOMA	-	-	-	-	DFNA5	ENST00000419307,p.P141L|NM_004403,p.P305L|ENST00000409970,p.P141L|ENST00000409775,p.P305L|NM_001127453,p.P305L|ENST00000342947,p.P305L|NM_001127454,p.P141L|ENST00000545231,p.P141L|uc003sxa.1,p.P305L|uc010kus.1,p.P305L|uc010kut.1,p.P141L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kut.1	nonsynonymous SNV	exon6	c.C422T	p.P141L	ERNFHPFAELPEPQQTALSDIFQAV	ERNFHPFAELPELQQTALSDIFQAV	5.0	9.0	-	-	3713_7:24747822-24747822 G>A_ERNFHPFAELPELQQTALSDIFQAV	0.0
X:40526037-40526037 G>A	1.0	4000	MELANOMA	-	-	-	-	MED14	NM_004229,p.P1067L|uc004dex.4,p.P1067L|ENST00000324817,p.P1067L	protein_coding, processed_transcript	uc004dex.4	nonsynonymous SNV	exon24	c.C3200T	p.P1067L	GALRAPSPASFVPTPPPSSHGISIG	GALRAPSPASFVLTPPPSSHGISIG	10.0	10.0	-	-	4000_X:40526037-40526037 G>A_GALRAPSPASFVLTPPPSSHGISIG	0.0
3:49720513-49720513 G>A	1.0	4345	COLORECTAL	-	-	-	-	APEH	NM_001640,p.R676Q|ENST00000296456,p.R676Q|uc010hkw.1,p.R681Q|uc003cxf.3,p.R676Q|ENST00000438011,p.R681Q	retained_intron, protein_coding, nonsense_mediated_decay	uc010hkw.1	nonsynonymous SNV	exon21	c.G2042A	p.R681Q	KTPLLLMLGQEDRRVPFKQGMEYYR	KTPLLLMLGQEDQRVPFKQGMEYYR	9.0	9.0	-	-	4345_3:49720513-49720513 G>A_KTPLLLMLGQEDQRVPFKQGMEYYR	0.0
16:23490232-23490232 C>T	1.0	4213	COLORECTAL	-	-	-	-	GGA2	NM_015044,p.G377E|ENST00000309859,p.G377E|uc002dlq.3,p.G377E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dlq.3	nonsynonymous SNV	exon12	c.G1130A	p.G377E	VPSLLHQDLAALGISDAPVTGMVSG	VPSLLHQDLAALEISDAPVTGMVSG	10.0	4.0	-	-	4213_16:23490232-23490232 C>T_VPSLLHQDLAALEISDAPVTGMVSG	0.0
12:22487096-22487096 G>-	0.0	4252	COLORECTAL	-	-	-	-	ST8SIA1	uc001rfo.4,p.P24fs|ENST00000396037,p.P24fs|ENST00000261197,p.P24fs|NM_003034,p.P24fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc001rfo.4	frameshift deletion	exon1	c.71delC	p.P24fs	SRGAMAVLAWKFPRTRLPMGASALC	SRGAMAVLAWKFRGPGCPWEPVPSVSWSSVGSTSSPSTGCPTRKRSCRGCCNRARRGGGTRPRPERSGNKWKTAATLPISLL	5.0	8.0	-	-	4252_12:22487096-22487096 G>-_SRGAMAVLAWKFRGPGCPWEPVPSVSWSSVGSTSSPSTGCPTRKRSCRGCCNRARRGGGTRPRPERSGNKWKTAATLPISLL	0.0
14:105169711-105169711 C>T	1.0	3784	MELANOMA	-	-	-	-	INF2	NM_001031714,p.T196I|ENST00000392634,p.T196I|uc001ypc.2,p.T196I|NM_022489,p.T196I|uc001ypb.2,p.T196I|uc001yoy.4,p.T196I|ENST00000398337,p.T196I|NM_032714,p.T196I|ENST00000330634,p.T196I	retained_intron, protein_coding, nonsense_mediated_decay	uc001ypc.2	nonsynonymous SNV	exon4	c.C587T	p.T196I	ELSGSDNVPYVVTLLSVINAVILGP	ELSGSDNVPYVVILLSVINAVILGP	9.0	6.0	-	-	3784_14:105169711-105169711 C>T_ELSGSDNVPYVVILLSVINAVILGP	0.0
1:46032674-46032674 A>C	1.0	4000	MELANOMA	-	-	-	-	AKR1A1	uc001coe.3,p.H113P|NM_001202414,p.H113P|NM_001202413,p.H113P|ENST00000372070,p.H113P|ENST00000351829,p.H113P|NM_153326,p.H113P|uc021omx.1,p.H113P|uc021omy.1,p.H113P|NM_006066,p.H113P|ENST00000434299,p.H113P|uc001cod.3,p.H113P	protein_coding, processed_transcript	uc021omy.1	nonsynonymous SNV	exon5	c.A338C	p.H113P	DLQLEYLDLYLMHWPYAFERGDNPF	DLQLEYLDLYLMPWPYAFERGDNPF	10.0	5.0	-	-	4000_1:46032674-46032674 A>C_DLQLEYLDLYLMPWPYAFERGDNPF	0.0
4:39465195-39465195 A>G	0.0	4345	COLORECTAL	-	-	-	-	LIAS	NM_001278592,p.E90G|uc011bym.2,p.E90G	retained_intron, protein_coding, processed_transcript	uc011bym.2	nonsynonymous SNV	exon3	c.A269G	p.E90G	LDVPILESVGEVENMPPPQPRSW	LDVPILESVGEVGNMPPPQPRSW	7.0	4.0	-	-	4345_4:39465195-39465195 A>G_LDVPILESVGEVGNMPPPQPRSW	0.0
15:24921084-24921084 G>A	0.0	4196	COLORECTAL	-	-	-	-	NPAP1	ENST00000329468,p.A24T|NM_018958,p.A24T|uc001ywo.3,p.A24T	protein_coding	uc001ywo.3	nonsynonymous SNV	exon1	c.G70A	p.A24T	CRRRPLPGPGRGAPAPLSRDASPPG	CRRRPLPGPGRGTPAPLSRDASPPG	3.0	8.0	-	-	4196_15:24921084-24921084 G>A_CRRRPLPGPGRGTPAPLSRDASPPG	0.0
19:50912441-50912441 G>A	1.0	4160	COLORECTAL	-	-	-	1	POLD1	uc002psc.5,p.R652Q|ENST00000599857,p.R652Q|ENST00000600859,p.R652Q|ENST00000440232,p.R652Q|uc010eny.4,p.R678Q|ENST00000595904,p.R678Q|uc002psb.5,p.R652Q|NM_002691,p.R652Q|NM_001256849,p.R652Q	retained_intron, protein_coding, nonsense_mediated_decay	uc010eny.4	nonsynonymous SNV	exon15	c.G2033A	p.R678Q	TPTGDEFVKTSVRKGLLPQILENLL	TPTGDEFVKTSVQKGLLPQILENLL	9.0	7.0	-	-	4160_19:50912441-50912441 G>A_TPTGDEFVKTSVQKGLLPQILENLL	0.0
3:126071131-126071131 G>A	0.0	4281	COLORECTAL	-	-	-	-	KLF15	NM_014079,p.T212M|uc011bkk.1,p.T212M|ENST00000296233,p.T212M	protein_coding, processed_transcript	uc011bkk.1	nonsynonymous SNV	exon2	c.C635T	p.T212M	SAGGAQGPGGGPTPDGPIPVLLQIQ	SAGGAQGPGGGPMPDGPIPVLLQIQ	2.0	7.0	-	-	4281_3:126071131-126071131 G>A_SAGGAQGPGGGPMPDGPIPVLLQIQ	0.0
3:20153134-20153134 C>T	1.0	3713	MELANOMA	-	-	ID=COSM2948441;OCCURENCE=1(liver)	-	KAT2B	ENST00000263754,p.R300W|NM_003884,p.R300W|uc003cbq.3,p.R300W	retained_intron, protein_coding, processed_transcript	uc003cbq.3	nonsynonymous SNV	exon6	c.C898T	p.R300W	YCNVPQFCDSLPRYETTQVFGRTLL	YCNVPQFCDSLPWYETTQVFGRTLL	9.0	7.0	-	-	3713_3:20153134-20153134 C>T_YCNVPQFCDSLPWYETTQVFGRTLL	0.0
10:135352327-135352327 G>T	0.0	4284	COLORECTAL	-	-	-	-	CYP2E1	uc001lnk.1,p.L310F|uc001lnj.1,p.L447F|ENST00000252945,p.L447F|NM_000773,p.L447F|uc009ybl.1,p.L248F|ENST00000463117,p.L447F|uc009ybm.1,p.L101F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009ybm.1	nonsynonymous SNV	exon6	c.G303T	p.L101F	RVCAGEGLARMELFLLLCAILQHFN	RVCAGEGLARMEFFLLLCAILQHFN	4.0	10.0	CD8	-	4284_10:135352327-135352327 G>T_RVCAGEGLARMEFFLLLCAILQHFN	1.0
1:181021388-181021388 G>A	1.0	4134	NSCLC	-	-	-	-	MR1	ENST00000367579,p.V163I|NM_001194999,p.V163I|uc001goq.2,p.V208I|NM_001531,p.V208I|uc001gor.2,p.V163I|ENST00000367580,p.V208I	retained_intron, protein_coding, processed_transcript	uc001gor.2	nonsynonymous SNV	exon5	c.G487A	p.V163I	DTLQRTEPPLVRVNRKETFPGVTAL	DTLQRTEPPLVRINRKETFPGVTAL	6.0	10.0	-	-	4134_1:181021388-181021388 G>A_DTLQRTEPPLVRINRKETFPGVTAL	0.0
11:101929624-101929624 A>T	1.0	4284	COLORECTAL	-	-	-	-	C11orf70	ENST00000534360,p.D69V|ENST00000434758,p.D69V|NM_032930,p.D69V|NM_001195005,p.D69V|ENST00000526781,p.D69V|uc001pgp.3,p.D69V|uc001pgq.3,p.D31V|uc001pgo.3,p.D69V	retained_intron, protein_coding	uc001pgq.3	nonsynonymous SNV	exon2	c.A92T	p.D31V	YRKDDFVMAFFKDPNVIPNLKLLSD	YRKDDFVMAFFKVPNVIPNLKLLSD	5.0	4.0	-	-	4284_11:101929624-101929624 A>T_YRKDDFVMAFFKVPNVIPNLKLLSD	0.0
3:100594412-100594412 C>T	0.0	4252	COLORECTAL	-	-	-	-	ABI3BP	ENST00000471714,p.V260I|ENST00000527258,p.V179I|uc003dun.3,p.V260I|NM_015429,p.V260I|ENST00000495063,p.V260I|ENST00000284322,p.V260I|uc003dup.4,p.V253I|uc003duo.2,p.V253I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003dup.4	nonsynonymous SNV	exon8	c.G757A	p.V253I	IPITIIKQVIQNVTHKDSAKSPEKA	IPITIIKQVIQNITHKDSAKSPEKA	6.0	9.0	-	-	4252_3:100594412-100594412 C>T_IPITIIKQVIQNITHKDSAKSPEKA	0.0
4:145039891-145039891 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GYPA	NM_002099,p.L83I|uc031shj.1,p.L83I|uc011cib.2,p.L50I|ENST00000535709,p.L57I|uc003ijo.4,p.L83I|ENST00000360771,p.L83I|ENST00000324022,p.L50I|uc031she.1,p.L50I	retained_intron, protein_coding, nonsense_mediated_decay	uc031shj.1	nonsynonymous SNV	exon4	c.C247A	p.L83I	YPPEEETGERVQLAHHFSEPEITLI	YPPEEETGERVQIAHHFSEPEITLI	1.0	9.0	-	-	4258_4:145039891-145039891 G>T_YPPEEETGERVQIAHHFSEPEITLI	0.0
X:106228351-106228351 G>A	1.0	4134	NSCLC	-	-	ID=COSM754723,COSM754722;OCCURENCE=1(lung)	-	MORC4	uc004emv.4,p.R217C|NM_001085354,p.R217C|NM_024657,p.R217C|ENST00000255495,p.R217C|ENST00000355610,p.R217C|uc004emu.4,p.R217C	retained_intron, protein_coding	uc004emv.4	nonsynonymous SNV	exon5	c.C649T	p.R217C	AQFDAIPGKKGTRVLIWNIRRNKNG	AQFDAIPGKKGTCVLIWNIRRNKNG	7.0	7.0	-	-	4134_X:106228351-106228351 G>A_AQFDAIPGKKGTCVLIWNIRRNKNG	0.0
17:26851012-26851012 T>G	0.0	4258	ENDOMETRIAL	-	-	-	-	FOXN1	NM_003593,p.S9A|ENST00000579795,p.S9A|uc002hbj.3,p.S9A|ENST00000226247,p.S9A|uc010crm.3,p.S9A|ENST00000577936,p.S9A	protein_coding	uc010crm.3	nonsynonymous SNV	exon2	c.T25G	p.S9A	MVSLPPPQSDVTLPGPTRLEG	MVSLPPPQADVTLPGPTRLEG	1.0	8.0	-	-	4258_17:26851012-26851012 T>G_MVSLPPPQADVTLPGPTRLEG	0.0
12:63974550-63974550 A>G	0.0	4095	COLORECTAL	-	-	-	-	DPY19L2	uc001srp.1,p.S598P|NM_173812,p.S598P|ENST00000413230,p.S45P|ENST00000324472,p.S598P|uc010sso.1,p.S45P	retained_intron, protein_coding, nonsense_mediated_decay	uc010sso.1	nonsynonymous SNV	exon3	c.T133C	p.S45P	FEKVIFGILTVMSIQGYANLRNQWS	FEKVIFGILTVMPIQGYANLRNQWS	4.0	7.0	-	-	4095_12:63974550-63974550 A>G_FEKVIFGILTVMPIQGYANLRNQWS	0.0
22:38130881-38130881 C>T	0.0	4287	COLORECTAL	-	-	-	-	TRIOBP	ENST00000406386,p.T1513M|uc003atr.3,p.T1513M|uc003atu.3,p.T1341M|NM_001039141,p.T1513M	retained_intron, protein_coding, nonsense_mediated_decay	uc003atu.3	nonsynonymous SNV	exon7	c.C4022T	p.T1341M	ELPRELGKRSPLTSPPENWGGPAES	ELPRELGKRSPLMSPPENWGGPAES	9.0	9.0	-	-	4287_22:38130881-38130881 C>T_ELPRELGKRSPLMSPPENWGGPAES	0.0
17:38547772-38547772 T>C	1.0	4180	BREAST	-	-	-	-	TOP2A	uc002huq.3,p.K1418R|NM_001067,p.K1418R|ENST00000423485,p.K1418R	retained_intron, protein_coding	uc002huq.3	nonsynonymous SNV	exon33	c.A4253G	p.K1418R	TNPVPKKNVTVKKTAAKSQSSTSTT	TNPVPKKNVTVKRTAAKSQSSTSTT	10.0	8.0	-	-	4180_17:38547772-38547772 T>C_TNPVPKKNVTVKRTAAKSQSSTSTT	0.0
16:48230197-48230197 C>G	0.0	3775	CERVICAL	-	-	-	-	ABCC11	ENST00000537808,p.W751C	retained_intron, protein_coding, processed_transcript	ENST00000537808	nonsynonymous SNV	exon17	c.G2253C	p.W751C	SCRSISSHRRRRWKKAP	SCRSISSHRRRRCKKAP	2.0	10.0	-	-	3775_16:48230197-48230197 C>G_SCRSISSHRRRRCKKAP	0.0
X:63411110-63411110 G>A	0.0	3998	MELANOMA	-	-	-	1	AMER1	ENST00000403336,p.P686L|ENST00000374869,p.P686L|ENST00000330258,p.P686L|uc022byb.1,p.P686L|uc004dvo.3,p.P686L|NM_152424,p.P686L	protein_coding	uc022byb.1	nonsynonymous SNV	exon1	c.C2057T	p.P686L	SQISHRGITSAFPTTASSEPDWRDF	SQISHRGITSAFLTTASSEPDWRDF	4.0	10.0	-	-	3998_X:63411110-63411110 G>A_SQISHRGITSAFLTTASSEPDWRDF	0.0
19:11493888-11493888 C>A	1.0	4287	COLORECTAL	-	-	-	-	EPOR	ENST00000591958,p.G81W	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000591958	nonsynonymous SNV	exon3	c.G241T	p.G81W	VTAGDTALLAARGPEELLCFTERLE	VTAGDTALLAARWPEELLCFTERLE	5.0	10.0	-	-	4287_19:11493888-11493888 C>A_VTAGDTALLAARWPEELLCFTERLE	0.0
11:55658785-55658785 C>T	1.0	3784	MELANOMA	-	-	ID=COSM1298151,COSM1298150;OCCURENCE=1(urinary_tract)	-	TRIM51	uc010riq.2,p.H203Y|ENST00000449290,p.H346Y|NM_032681,p.H346Y|uc010rip.2,p.H346Y|ENST00000244891,p.H203Y	protein_coding	uc010riq.2	nonsynonymous SNV	exon5	c.C607T	p.H203Y	QAFTSGKYYWEVHMGDSWNWAFGVC	QAFTSGKYYWEVYMGDSWNWAFGVC	4.0	9.0	-	-	3784_11:55658785-55658785 C>T_QAFTSGKYYWEVYMGDSWNWAFGVC	0.0
5:140784024-140784024 C>T	1.0	4301	MELANOMA	-	-	-	-	PCDHGA9	uc003lkh.2,p.S502F|uc011dax.2,p.S502F|NM_018921,p.S502F|NM_032089,p.S502F|ENST00000573521,p.S502F	protein_coding	uc011dax.2	nonsynonymous SNV	exon1	c.C1505T	p.S502F	SLAEDTIQGSPLSTYVSINSDTGVL	SLAEDTIQGSPLFTYVSINSDTGVL	6.0	6.0	-	-	4301_5:140784024-140784024 C>T_SLAEDTIQGSPLFTYVSINSDTGVL	0.0
17:34340793-34340793 G>A	0.0	4266	COLORECTAL	-	-	-	-	CCL23	uc002hks.1,p.P98L|NM_145898,p.P81L|NM_005064,p.P98L|ENST00000293280,p.P98L|uc002hkt.1,p.P81L|ENST00000591423,p.P81L	protein_coding, nonsense_mediated_decay	uc002hkt.1	nonsynonymous SNV	exon3	c.C242T	p.P81L	ESYFETNSECSKPGVIFLTKKGRRF	ESYFETNSECSKLGVIFLTKKGRRF	5.0	1.0	-	-	4266_17:34340793-34340793 G>A_ESYFETNSECSKLGVIFLTKKGRRF	0.0
6:109258108-109258108 T>G	1.0	4287	COLORECTAL	-	-	-	-	ARMC2	ENST00000368972,p.L336R|NM_032131,p.L501R|uc011eao.2,p.L336R|ENST00000392644,p.L501R|uc003pss.4,p.L501R|NM_001286609,p.L336R	protein_coding, processed_transcript	uc011eao.2	nonsynonymous SNV	exon11	c.T1007G	p.L336R	DVCTNIARIFSKLTSYRDCCTALAS	DVCTNIARIFSKRTSYRDCCTALAS	7.0	6.0	-	-	4287_6:109258108-109258108 T>G_DVCTNIARIFSKRTSYRDCCTALAS	0.0
12:25398284-25398284 C>G	0.0	4235	COLORECTAL	-	-	ID=COSM1140134,COSM522;OCCURENCE=3(upper_aerodigestive_tract),1(bone),1(oesophagus),25(stomach),6(central_nervous_system),1(thymus),4(cervix),1(testis),33(haematopoietic_and_lymphoid_tissue),1(gastrointestinal_tract_(site_indeterminate)),6(thyroid),1(peritoneum),290(lung),55(endometrium),35(ovary),3(soft_tissue),7(urinary_tract),1(liver),75(pancreas),2(prostate),29(biliary_tract),1086(large_intestine),1(skin),1(breast),9(small_intestine)	1	KRAS	NM_004985,p.G12A|uc001rgq.1,p.G12A|NM_033360,p.G12A|uc001rgp.1,p.G12A|ENST00000556131,p.G12A|ENST00000256078,p.G12A|ENST00000557334,p.G12A|ENST00000311936,p.G12A	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35C	p.G12A	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGAAGVGKSALTIQLI	6.0	9.0	-	-	4235_12:25398284-25398284 C>G_MTEYKLVVVGAAGVGKSALTIQLI	0.0
12:56522185-56522185 C>A	1.0	4317	COLORECTAL	-	-	-	-	ESYT1	uc001sjr.3,p.P28T|ENST00000267113,p.P28T|NM_001184796,p.P28T|ENST00000394048,p.P28T|uc001sjq.3,p.P28T|ENST00000541590,p.P28T|NM_015292,p.P28T	retained_intron, protein_coding, processed_transcript	uc001sjr.3	nonsynonymous SNV	exon1	c.C82A	p.P28T	QPSAPSDPTDQPPAAHAKPDPGSGG	QPSAPSDPTDQPTAAHAKPDPGSGG	9.0	7.0	-	-	4317_12:56522185-56522185 C>A_QPSAPSDPTDQPTAAHAKPDPGSGG	0.0
2:185801138-185801138 A>T	0.0	3919	MELANOMA	-	-	-	-	ZNF804A	NM_194250,p.S339C|ENST00000302277,p.S339C|uc002uph.3,p.S339C	protein_coding	uc002uph.3	nonsynonymous SNV	exon4	c.A1015T	p.S339C	NSVPLADQIPLESVVINEDIPVSGN	NSVPLADQIPLECVVINEDIPVSGN	1.0	1.0	-	-	3919_2:185801138-185801138 A>T_NSVPLADQIPLECVVINEDIPVSGN	0.0
14:81743485-81743485 G>A	0.0	3998	MELANOMA	-	-	-	-	STON2	ENST00000555447,p.P724S|uc001xvk.2,p.P724S|NM_001256430,p.P724S|ENST00000267540,p.P724S|uc010tvt.3,p.P521S|NM_033104,p.P724S|uc010tvu.3,p.P724S	retained_intron, protein_coding, processed_transcript	uc010tvu.3	nonsynonymous SNV	exon5	c.C2170T	p.P724S	GFSANRDPLTQVPCENVMIRYPVPS	GFSANRDPLTQVSCENVMIRYPVPS	6.0	10.0	-	-	3998_14:81743485-81743485 G>A_GFSANRDPLTQVSCENVMIRYPVPS	0.0
6:166827413-166827413 C>T	1.0	4275	COLORECTAL	-	-	-	-	RPS6KA2	ENST00000510118,p.V674M|ENST00000481261,p.V560M|NM_001006932,p.V657M|uc003qvc.1,p.V657M|ENST00000405189,p.V560M|ENST00000503859,p.V657M|uc003qvd.1,p.V674M|uc003qvb.1,p.V649M|uc011ego.1,p.V560M|uc010kkl.1,p.V560M|ENST00000265678,p.V649M|uc010kkk.1,p.V81M|NM_021135,p.V649M	protein_coding, processed_transcript	uc011ego.1	nonsynonymous SNV	exon20	c.G1678A	p.V560M	NWDSISDAAKDVVSKMLHVDPHQRL	NWDSISDAAKDVMSKMLHVDPHQRL	9.0	3.0	-	-	4275_6:166827413-166827413 C>T_NWDSISDAAKDVMSKMLHVDPHQRL	0.0
8:145698736-145698736 C>T	1.0	4110	BILE DUCT	-	-	-	-	KIFC2	uc003zda.3,p.A195V|NM_145754,p.A807V|uc003zcz.3,p.A807V|ENST00000301332,p.A807V	retained_intron, protein_coding, processed_transcript	uc003zda.3	nonsynonymous SNV	exon1	c.C584T	p.A195V	AVLHAPVPTTARARLSRPQRACPSS	AVLHAPVPTTARVRLSRPQRACPSS	6.0	10.0	-	-	4110_8:145698736-145698736 C>T_AVLHAPVPTTARVRLSRPQRACPSS	0.0
7:100460306-100460306 C>T	1.0	3879	MELANOMA	-	-	-	-	SLC12A9	NM_020246,p.S572F|uc031syn.1,p.S572F|uc011kki.2,p.S103F|NM_001267814,p.S483F|ENST00000415287,p.S483F|NM_001267812,p.S572F|ENST00000428758,p.S572F|ENST00000275729,p.S483F|ENST00000540482,p.S572F|uc003uws.3,p.S103F|uc003uwt.3,p.S308F|uc003uwv.3,p.S103F|uc003uwp.4,p.S572F|uc003uwr.3,p.S308F|uc003uwq.4,p.S483F|ENST00000354161,p.S572F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031syn.1	nonsynonymous SNV	exon13	c.C1715T	p.S572F	YVLGHVTLGDLDSLPSDPVQPQYGA	YVLGHVTLGDLDFLPSDPVQPQYGA	7.0	5.0	-	-	3879_7:100460306-100460306 C>T_YVLGHVTLGDLDFLPSDPVQPQYGA	0.0
1:201170931-201170931 G>A	1.0	3713	MELANOMA	-	-	-	-	IGFN1	ENST00000437879,p.D240N|ENST00000335211,p.D240N|uc001gwc.3,p.D240N|ENST00000451870,p.D240N|NM_001164586,p.D240N	retained_intron, protein_coding, nonsense_mediated_decay	uc001gwc.3	nonsynonymous SNV	exon9	c.G718A	p.D240N	GNAKFDLELDLKDSQSKIYLYKDGE	GNAKFDLELDLKNSQSKIYLYKDGE	1.0	9.0	-	-	3713_1:201170931-201170931 G>A_GNAKFDLELDLKNSQSKIYLYKDGE	0.0
1:76877919-76877919 C>T	0.0	4155	MELANOMA	0.0005	-	ID=COSM166814;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	-	ST6GALNAC3	NM_152996,p.A147V|uc001dhh.2,p.A147V|uc010orh.1,p.A82V|NM_001160011,p.A147V|uc001dhg.4,p.A147V|ENST00000328299,p.A147V	protein_coding, processed_transcript	uc010orh.1	nonsynonymous SNV	exon2	c.C245T	p.A82V	LLLKNPDYFFKEANTTIYVIWGPFR	LLLKNPDYFFKEVNTTIYVIWGPFR	6.0	5.0	-	-	4155_1:76877919-76877919 C>T_LLLKNPDYFFKEVNTTIYVIWGPFR	0.0
3:48423512-48423512 G>A	0.0	4275	COLORECTAL	-	-	ID=COSM1206874;OCCURENCE=1(large_intestine)	-	FBXW12	ENST00000445170,p.R392H|NM_207102,p.R411H|uc003csr.3,p.R411H|ENST00000415155,p.R341H|uc003css.3,p.R341H|ENST00000436231,p.R254H|ENST00000296438,p.R411H|uc010hjv.3,p.R392H|NM_001159927,p.R341H|uc010hjw.3,p.R310H|NM_001159929,p.R392H	retained_intron, protein_coding, processed_transcript	uc010hjw.3	nonsynonymous SNV	exon7	c.G929A	p.R310H	NSVHVYMWEEGGRHPYLRSCCHLEN	NSVHVYMWEEGGHHPYLRSCCHLEN	1.0	9.0	-	-	4275_3:48423512-48423512 G>A_NSVHVYMWEEGGHHPYLRSCCHLEN	0.0
11:43419634-43419634 A>C	0.0	4320	COLORECTAL	-	-	-	-	TTC17	uc001mxi.3,p.K343N|uc001mxh.3,p.K343N|ENST00000299240,p.K343N|uc001mxj.3,p.K113N|ENST00000039989,p.K343N|uc010rfj.2,p.K286N|NM_018259,p.K343N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rfj.2	nonsynonymous SNV	exon7	c.A858C	p.K286N	AIKRKHAVLCQQKLEQKLEAQHRSL	AIKRKHAVLCQQNLEQKLEAQHRSL	9.0	6.0	-	-	4320_11:43419634-43419634 A>C_AIKRKHAVLCQQNLEQKLEAQHRSL	0.0
14:25043994-25043994 C>T	0.0	4037	NSCLC	-	-	-	-	CTSG	ENST00000216336,p.A76T|uc001wpq.3,p.A76T|NM_001911,p.A76T	retained_intron, protein_coding	uc001wpq.3	nonsynonymous SNV	exon3	c.G226A	p.A76T	HCWGSNINVTLGAHNIQRRENTQQH	HCWGSNINVTLGTHNIQRRENTQQH	1.0	10.0	-	-	4037_14:25043994-25043994 C>T_HCWGSNINVTLGTHNIQRRENTQQH	0.0
10:7866335-7866335 G>A	0.0	4316	COLORECTAL	-	-	-	-	TAF3	NM_031923,p.G74E|uc010qbd.3,p.G74E|ENST00000344293,p.G74E	protein_coding	uc010qbd.3	nonsynonymous SNV	exon2	c.G221A	p.G74E	ILDDVGEAFQLMGVSLHELEDYIHN	ILDDVGEAFQLMEVSLHELEDYIHN	5.0	4.0	-	-	4316_10:7866335-7866335 G>A_ILDDVGEAFQLMEVSLHELEDYIHN	0.0
2:141291664-141291664 C>T	0.0	4259	COLORECTAL	0.0	-	-	1	LRP1B	ENST00000389484,p.R2563H|NM_018557,p.R2563H|uc002tvj.1,p.R2563H	protein_coding, processed_transcript	uc002tvj.1	nonsynonymous SNV	exon47	c.G7688A	p.R2563H	SCRRGFKPCYNRRCIPHGKLCDGEN	SCRRGFKPCYNRHCIPHGKLCDGEN	3.0	10.0	-	-	4259_2:141291664-141291664 C>T_SCRRGFKPCYNRHCIPHGKLCDGEN	0.0
1:93712494-93712494 A>G	1.0	4037	NSCLC	-	-	-	-	CCDC18	NM_206886,p.K1061E|uc021opx.1,p.K1061E|ENST00000557479,p.K1179E|ENST00000343253,p.K1060E|ENST00000401026,p.K1061E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021opx.1	nonsynonymous SNV	exon23	c.A3181G	p.K1061E	LEGTLEKSELELKECNKQIESLNDK	LEGTLEKSELELEECNKQIESLNDK	5.0	10.0	-	-	4037_1:93712494-93712494 A>G_LEGTLEKSELELEECNKQIESLNDK	0.0
13:111155614-111155614 C>T	1.0	3713	MELANOMA	-	-	-	-	COL4A2	ENST00000360467,p.L1342F|NM_001846,p.L1342F|uc001vqx.3,p.L1342F	protein_coding, processed_transcript	uc001vqx.3	nonsynonymous SNV	exon42	c.C4024T	p.L1342F	DSGPQGRPGVFGLPGEKGPRGEQGF	DSGPQGRPGVFGFPGEKGPRGEQGF	8.0	6.0	-	-	3713_13:111155614-111155614 C>T_DSGPQGRPGVFGFPGEKGPRGEQGF	0.0
20:58468231-58468231 C>G	0.0	4266	COLORECTAL	-	-	-	-	SYCP2	uc002yaz.3,p.D587H|NM_014258,p.D587H|ENST00000371001,p.D587H|ENST00000357552,p.D587H|ENST00000446834,p.D587H	retained_intron, protein_coding, processed_transcript	uc002yaz.3	nonsynonymous SNV	exon21	c.G1759C	p.D587H	NQNFSELQDVIPDSQAAEKRDHTIL	NQNFSELQDVIPHSQAAEKRDHTIL	4.0	7.0	-	-	4266_20:58468231-58468231 C>G_NQNFSELQDVIPHSQAAEKRDHTIL	0.0
4:96070045-96070045 G>T	0.0	4126	NSCLC	-	-	-	-	BMPR1B	ENST00000264568,p.W408L|ENST00000394931,p.W408L|NM_001256792,p.W408L|uc031sgn.1,p.W438L|NM_001203,p.W408L|uc003htn.4,p.W408L|NM_001256793,p.W438L|ENST00000440890,p.W438L|uc010ilb.3,p.W408L|ENST00000509540,p.W408L|uc003htm.4,p.W408L|ENST00000515059,p.W408L|ENST00000512312,p.W408L|NM_001256794,p.W408L|uc031sgm.1,p.W408L	protein_coding	uc031sgn.1	nonsynonymous SNV	exon9	c.G1313T	p.W438L	IMADMYSFGLILWEVARRCVSGGIV	IMADMYSFGLILLEVARRCVSGGIV	3.0	4.0	-	-	4126_4:96070045-96070045 G>T_IMADMYSFGLILLEVARRCVSGGIV	0.0
8:57080755-57080755 C>T	0.0	4287	COLORECTAL	-	-	-	1	PLAG1	ENST00000316981,p.R25H|uc003xsr.4,p.R25H|ENST00000429357,p.R25H|NM_001114634,p.R25H|NM_002655,p.R25H|uc003xsq.4,p.R25H|uc010lyi.3,p.R25H	retained_intron, protein_coding, processed_transcript	uc010lyi.3	nonsynonymous SNV	exon3	c.G74A	p.R25H	RDTQKVPSGKRKRGETKPRKNFPCQ	RDTQKVPSGKRKHGETKPRKNFPCQ	5.0	10.0	-	-	4287_8:57080755-57080755 C>T_RDTQKVPSGKRKHGETKPRKNFPCQ	0.0
11:61723302-61723302 A>T	0.0	4287	COLORECTAL	-	-	-	-	BEST1	ENST00000524926,p.Q120H|ENST00000378042,p.Q60H|ENST00000526988,p.Q14H|uc010rlp.2,p.Q60H|uc001nsr.2,p.Q60H|uc010rlv.2,p.Q14H|uc001nsq.3,p.Q14H|uc010rlt.2,p.Q60H|NM_004183,p.Q120H|uc010rlu.1,p.Q14H|NM_001300786,p.Q60H|uc010rlr.1,p.Q120H|ENST00000534553,p.Q14H|uc001nst.3,p.Q60H|uc001nss.3,p.Q120H|NM_001139443,p.Q60H|ENST00000449131,p.Q60H|ENST00000378043,p.Q120H|uc010rlq.1,p.Q60H|NM_001300787,p.Q60H|ENST00000435278,p.Q120H	retained_intron, protein_coding, nonsense_mediated_decay	uc010rlv.2	nonsynonymous SNV	exon2	c.A42T	p.Q14H	SLVSGFVEGKDEQGRLLRRTLIRYA	SLVSGFVEGKDEHGRLLRRTLIRYA	5.0	8.0	-	-	4287_11:61723302-61723302 A>T_SLVSGFVEGKDEHGRLLRRTLIRYA	0.0
19:49845705-49845705 G>C	1.0	4046	OVARIAN	-	-	-	-	TEAD2	NM_003598,p.T407S|uc010yao.3,p.T279S|NM_001256660,p.T411S|NM_001256659,p.T410S|ENST00000598810,p.T411S|uc002pnh.4,p.T411S|NM_001256658,p.T410S|ENST00000593945,p.T411S|ENST00000311227,p.T407S|ENST00000377214,p.T410S|ENST00000539846,p.T279S|uc031rls.1,p.T411S|NM_001256661,p.T411S|uc010emw.4,p.T410S|uc002png.4,p.T410S|ENST00000601519,p.T410S|uc002pni.4,p.T410S|uc002pnj.4,p.T407S|NM_001256662,p.T279S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031rls.1	nonsynonymous SNV	exon12	c.C1232G	p.T411S	ERYMMNSVLENFTILQVVTNRDTQE	ERYMMNSVLENFSILQVVTNRDTQE	10.0	10.0	-	-	4046_19:49845705-49845705 G>C_ERYMMNSVLENFSILQVVTNRDTQE	0.0
16:633537-633537 A>C	1.0	4345	COLORECTAL	-	-	-	-	PIGQ	NM_148920,p.K729T|ENST00000026218,p.K729T|uc002chp.3,p.K299T|uc002cho.3,p.K729T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002chp.3	nonsynonymous SNV	exon2	c.A896C	p.K299T	PSAEQHPASGGLKQSLTPVPSGPGP	PSAEQHPASGGLTQSLTPVPSGPGP	7.0	9.0	-	-	4345_16:633537-633537 A>C_PSAEQHPASGGLTQSLTPVPSGPGP	0.0
4:89415439-89415439 C>T	1.0	4071	COLORECTAL	-	-	-	-	HERC5	NM_016323,p.P801S|uc011cdm.3,p.P439S|ENST00000508159,p.P439S|ENST00000264350,p.P801S|uc003hrt.4,p.P801S	retained_intron, protein_coding, processed_transcript	uc011cdm.3	nonsynonymous SNV	exon12	c.C1315T	p.P439S	PLALFKKLLDQMPSLEDLKELSPDL	PLALFKKLLDQMSSLEDLKELSPDL	4.0	10.0	-	-	4071_4:89415439-89415439 C>T_PLALFKKLLDQMSSLEDLKELSPDL	0.0
15:40758204-40758204 C>T	1.0	2369	MELANOMA	-	-	-	-	BAHD1	ENST00000561234,p.P739S|uc001zlu.2,p.P740S|ENST00000416165,p.P740S|uc001zlv.2,p.P737S|ENST00000560846,p.P737S|NM_001301132,p.P739S|NM_014952,p.P740S|uc001zlt.2,p.P739S|uc010bbp.1,p.P736S	retained_intron, protein_coding	uc010bbp.1	nonsynonymous SNV	exon7	c.C2206T	p.P736S	EGLPSRKTALVPPSADYSTPPHRTV	EGLPSRKTALVPSSADYSTPPHRTV	7.0	8.0	-	-	2369_15:40758204-40758204 C>T_EGLPSRKTALVPSSADYSTPPHRTV	0.0
3:186507958-186507958 C>G	1.0	4244	COLORECTAL	-	-	-	-	RFC4	NM_002916,p.Q323H|ENST00000433496,p.Q296H|ENST00000296273,p.Q323H|NM_181573,p.Q323H|uc003fqz.3,p.Q323H|ENST00000392481,p.Q323H|uc011bsc.2,p.Q323H	retained_intron, protein_coding, nonsense_mediated_decay	uc011bsc.2	nonsynonymous SNV	exon10	c.G969C	p.Q323H	HDVVVENNLSDKQKSIITEKLAEVD	HDVVVENNLSDKHKSIITEKLAEVD	9.0	4.0	-	-	4244_3:186507958-186507958 C>G_HDVVVENNLSDKHKSIITEKLAEVD	0.0
4:99363155-99363155 G>A	1.0	3784	MELANOMA	-	-	-	1	RAP1GDS1	uc003hua.4,p.E480K|uc003htw.4,p.E572K|uc003hty.4,p.E523K|uc003htv.4,p.E571K|NM_001100426,p.E572K|ENST00000408900,p.E522K|NM_001100428,p.E523K|NM_001100427,p.E571K|uc003htz.4,p.E522K|NM_001100429,p.E522K|ENST00000264572,p.E480K|uc003htx.4,p.E571K|NM_021159,p.E571K|ENST00000339360,p.E572K|NM_001100430,p.E480K|ENST00000408927,p.E571K|ENST00000453712,p.E571K|ENST00000380158,p.E523K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003hua.4	nonsynonymous SNV	exon13	c.G1438A	p.E480K	ICALMGSECLHKEVQDLAFLDVVSK	ICALMGSECLHKKVQDLAFLDVVSK	8.0	5.0	-	-	3784_4:99363155-99363155 G>A_ICALMGSECLHKKVQDLAFLDVVSK	0.0
8:55537910-55537910 G>A	0.0	3903	MELANOMA	-	-	ID=COSM1686061;OCCURENCE=2(skin)	-	RP1	NM_006269,p.E490K|uc003xsd.1,p.E490K|ENST00000220676,p.E490K	protein_coding	uc003xsd.1	nonsynonymous SNV	exon4	c.G1468A	p.E490K	KMIGQFSYSEERESGENKSEYHMFT	KMIGQFSYSEERKSGENKSEYHMFT	1.0	6.0	-	-	3903_8:55537910-55537910 G>A_KMIGQFSYSEERKSGENKSEYHMFT	0.0
7:6426892-6426892 C>T	1.0	2556	MELANOMA	-	-	ID=COSM1167878,COSM125734;OCCURENCE=3(NS),1(upper_aerodigestive_tract),1(breast),38(skin),1(endometrium)	1	RAC1	uc003spw.3,p.P29S|uc003spx.3,p.P29S|NM_018890,p.P29S|ENST00000348035,p.P29S|ENST00000356142,p.P29S|NM_006908,p.P29S	retained_intron, protein_coding, processed_transcript	uc003spx.3	nonsynonymous SNV	exon2	c.C85T	p.P29S	TCLLISYTTNAFPGEYIPTVFDNYS	TCLLISYTTNAFSGEYIPTVFDNYS	10.0	9.0	CD8	-	2556_7:6426892-6426892 C>T_TCLLISYTTNAFSGEYIPTVFDNYS	1.0
2:170066041-170066041 C>T	0.0	2359	MELANOMA	-	-	-	-	LRP2	NM_004525,p.G2131R|ENST00000263816,p.G2131R|uc002ues.3,p.G2131R	retained_intron, protein_coding, processed_transcript	uc002ues.3	nonsynonymous SNV	exon38	c.G6391A	p.G2131R	ASDNAIRRIKPDGSSLMNIVTHGIG	ASDNAIRRIKPDRSSLMNIVTHGIG	3.0	7.0	-	-	2359_2:170066041-170066041 C>T_ASDNAIRRIKPDRSSLMNIVTHGIG	0.0
3:154861251-154861251 C>T	1.0	3466	MELANOMA	-	-	-	-	MME	NM_007289,p.S403L|ENST00000492661,p.S403L|NM_007288,p.S403L|NM_007287,p.S403L|ENST00000360490,p.S403L|ENST00000493237,p.S403L|NM_000902,p.S403L|ENST00000462745,p.S403L|ENST00000460393,p.S403L	retained_intron, protein_coding, processed_transcript	NM_007289	nonsynonymous SNV	exon13	c.C1208T	p.S403L	RNAFRKALYGTTSETATWRRCANYV	RNAFRKALYGTTLETATWRRCANYV	4.0	4.0	-	-	3466_3:154861251-154861251 C>T_RNAFRKALYGTTLETATWRRCANYV	0.0
1:227182087-227182087 G>A	1.0	4298	COLORECTAL	-	-	-	-	CDC42BPA	uc009xes.3,p.P1653L|uc001hqs.3,p.P1600L|NM_003607,p.P1681L|ENST00000535525,p.P1661L|uc001hqq.3,p.P980L|ENST00000366769,p.P1681L|ENST00000366765,p.P1694L|uc010pvs.2,p.P1661L|ENST00000334218,p.P1743L|ENST00000366764,p.P1653L|NM_014826,p.P1600L|uc001hqp.3,p.P899L|ENST00000366767,p.P1600L|uc001hqr.3,p.P1681L|ENST00000366766,p.P1716L	protein_coding, processed_transcript	uc010pvs.2	nonsynonymous SNV	exon36	c.C4982T	p.P1661L	PARDFDGEDSDSPRHSTASNSSNLS	PARDFDGEDSDSLRHSTASNSSNLS	8.0	8.0	-	-	4298_1:227182087-227182087 G>A_PARDFDGEDSDSLRHSTASNSSNLS	0.0
2:27016112-27016112 C>T	1.0	3713	MELANOMA	-	-	-	-	CENPA	ENST00000335756,p.R130W|NM_001809,p.R130W|ENST00000233505,p.R104W|uc002rhs.3,p.R104W|uc002rhr.3,p.R130W|NM_001042426,p.R104W	protein_coding, processed_transcript, nonsense_mediated_decay	uc002rhs.3	nonsynonymous SNV	exon3	c.C310T	p.R104W	RVTLFPKDVQLARRIRGLEEGLG	RVTLFPKDVQLAWRIRGLEEGLG	4.0	10.0	-	-	3713_2:27016112-27016112 C>T_RVTLFPKDVQLAWRIRGLEEGLG	0.0
19:52003519-52003519 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	SIGLEC12	uc002pwx.1,p.V155L|NM_033329,p.V37L|uc002pww.1,p.V37L|NM_053003,p.V155L|ENST00000291707,p.V155L|ENST00000598614,p.V37L	protein_coding, nonsense_mediated_decay	uc002pwx.1	nonsynonymous SNV	exon2	c.G463T	p.V155L	ASQDLLSRYRLEVPESVTVQEGLCV	ASQDLLSRYRLELPESVTVQEGLCV	3.0	8.0	-	-	4258_19:52003519-52003519 C>A_ASQDLLSRYRLELPESVTVQEGLCV	0.0
15:48766550-48766550 G>T	1.0	3713	MELANOMA	-	-	-	-	FBN1	uc001zwx.2,p.T1371N|NM_000138,p.T1371N|ENST00000316623,p.T1371N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zwx.2	nonsynonymous SNV	exon34	c.C4112A	p.T1371N	IKCTDLDECSNGTHMCSQHADCKNT	IKCTDLDECSNGNHMCSQHADCKNT	3.0	10.0	-	-	3713_15:48766550-48766550 G>T_IKCTDLDECSNGNHMCSQHADCKNT	0.0
13:114817595-114817595 G>A	1.0	3466	MELANOMA	-	-	-	-	RASA3	ENST00000389544,p.P38L|NM_007368,p.P70L|ENST00000334062,p.P70L|ENST00000542651,p.P70L|uc001vui.3,p.P70L|uc010tkk.2,p.P38L	protein_coding	uc010tkk.2	nonsynonymous SNV	exon3	c.C113T	p.P38L	CPFYGEDFYCEIPRSFRHLSFYIFD	CPFYGEDFYCEILRSFRHLSFYIFD	8.0	9.0	-	-	3466_13:114817595-114817595 G>A_CPFYGEDFYCEILRSFRHLSFYIFD	0.0
4:184236860-184236860 C>T	1.0	2556	MELANOMA	-	-	-	-	WWC2	uc003ivo.4,p.S314F|ENST00000504005,p.S868F|uc010irz.3,p.S527F|uc003ivk.4,p.S981F|ENST00000403733,p.S1186F|uc010irx.3,p.S1186F|NM_024949,p.S1186F|ENST00000508747,p.S314F|ENST00000448232,p.S1210F|uc010iry.3,p.S868F|ENST00000513834,p.S1137F|uc003ivn.4,p.S701F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010irz.3	nonsynonymous SNV	exon11	c.C1580T	p.S527F	IAYFTRAKISIPSLPADDV	IAYFTRAKISIPFLPADDV	8.0	3.0	-	-	2556_4:184236860-184236860 C>T_IAYFTRAKISIPFLPADDV	0.0
19:58290417-58290417 G>A	1.0	4346	COLORECTAL	-	-	-	-	ZNF586	NM_001077426,p.S112N|uc002qqe.3,p.S112N|ENST00000396150,p.S112N	protein_coding	uc002qqe.3	nonsynonymous SNV	exon2	c.G335A	p.S112N	DFILGKRPMSAVSVENHFTKALHSC	DFILGKRPMSAVNVENHFTKALHSC	8.0	5.0	-	-	4346_19:58290417-58290417 G>A_DFILGKRPMSAVNVENHFTKALHSC	0.0
X:15845471-15845471 G>A	1.0	4000	MELANOMA	-	-	-	-	AP1S2	uc010nex.4,p.L154F|NM_001272071,p.L154F	protein_coding, processed_transcript	uc010nex.4	nonsynonymous SNV	exon6	c.C460T	p.L154F	EDAKEAETPRSVLEEIGLT	EDAKEAETPRSVFEEIGLT	10.0	10.0	-	-	4000_X:15845471-15845471 G>A_EDAKEAETPRSVFEEIGLT	0.0
15:41961612-41961612 G>C	1.0	4046	OVARIAN	-	-	-	-	MGA	ENST00000570161,p.V174L|ENST00000389936,p.V174L|NM_001080541,p.V174L|NM_001164273,p.V174L|uc010ucy.2,p.V174L|ENST00000566718,p.V174L|ENST00000566586,p.V174L|ENST00000219905,p.V174L|uc001zog.1,p.V174L|uc010ucz.2,p.V174L|ENST00000563576,p.V174L|ENST00000545763,p.V174L	retained_intron, protein_coding, processed_transcript	uc010ucz.2	nonsynonymous SNV	exon2	c.G520C	p.V174L	SPSTGHYWMHQPVSFYKLKLTNNTL	SPSTGHYWMHQPLSFYKLKLTNNTL	6.0	7.0	-	-	4046_15:41961612-41961612 G>C_SPSTGHYWMHQPLSFYKLKLTNNTL	0.0
14:95033567-95033567 T>G	0.0	4238	COLORECTAL	-	-	-	-	SERPINA4	NM_001289033,p.L304V|uc001ydl.3,p.L304V|NM_001289032,p.L341V|uc001ydk.3,p.L304V|uc010avd.3,p.L341V|ENST00000557004,p.L304V|ENST00000298841,p.L304V|NM_006215,p.L304V|ENST00000555095,p.L304V	protein_coding	uc010avd.3	nonsynonymous SNV	exon3	c.T1021G	p.L341V	VLTPEMLMRWNNLLRKRNFYKKLEL	VLTPEMLMRWNNVLRKRNFYKKLEL	4.0	1.0	-	-	4238_14:95033567-95033567 T>G_VLTPEMLMRWNNVLRKRNFYKKLEL	0.0
1:43395317-43395317 T>C	1.0	4252	COLORECTAL	-	-	-	-	SLC2A1	NM_006516,p.I272V|ENST00000439722,p.I177V|uc001cik.2,p.I272V|ENST00000426263,p.I272V	protein_coding, processed_transcript	uc001cik.2	nonsynonymous SNV	exon6	c.A814G	p.I272V	LELFRSPAYRQPILIAVVLQLSQQL	LELFRSPAYRQPVLIAVVLQLSQQL	9.0	8.0	CD8	-	4252_1:43395317-43395317 T>C_LELFRSPAYRQPVLIAVVLQLSQQL	2.0
12:118465775-118465775 A>C	0.0	4317	COLORECTAL	-	-	-	-	RFC5	NM_181578,p.T250P|NM_007370,p.T271P|uc010syx.2,p.T250P|ENST00000392542,p.T250P|NM_001130112,p.T186P|ENST00000454402,p.T271P|uc001twq.3,p.T271P|uc010syz.2,p.T186P|ENST00000229043,p.T186P	retained_intron, protein_coding, processed_transcript	uc010syz.2	nonsynonymous SNV	exon10	c.A556C	p.T186P	FTTAYRNITELKTLKGLALHDILTE	FTTAYRNITELKPLKGLALHDILTE	7.0	1.0	-	-	4317_12:118465775-118465775 A>C_FTTAYRNITELKPLKGLALHDILTE	0.0
8:17053106-17053106 C>T	0.0	3713	MELANOMA	-	-	-	-	ZDHHC2	uc003wxe.3,p.P116S|ENST00000522184,p.P71S|ENST00000262096,p.P116S|NM_016353,p.P116S	retained_intron, protein_coding	uc003wxe.3	nonsynonymous SNV	exon4	c.C346T	p.P116S	HQEVLRRAAKDLPIYTRTMSGAIRY	HQEVLRRAAKDLSIYTRTMSGAIRY	2.0	5.0	-	-	3713_8:17053106-17053106 C>T_HQEVLRRAAKDLSIYTRTMSGAIRY	0.0
X:34149093-34149093 C>A	0.0	4287	COLORECTAL	-	-	-	-	FAM47A	NM_203408,p.G435W|ENST00000346193,p.G435W|uc004ddg.3,p.G435W	protein_coding	uc004ddg.3	nonsynonymous SNV	exon1	c.G1303T	p.G435W	NLLLYILKVLDSGRTLKDVWDRCEA	NLLLYILKVLDSWRTLKDVWDRCEA	1.0	8.0	-	-	4287_X:34149093-34149093 C>A_NLLLYILKVLDSWRTLKDVWDRCEA	0.0
19:19221525-19221525 C>T	1.0	4287	COLORECTAL	-	-	-	-	SLC25A42	ENST00000318596,p.S266F|NM_178526,p.S266F|uc002nlf.3,p.S266F	retained_intron, protein_coding, processed_transcript	uc002nlf.3	nonsynonymous SNV	exon8	c.C797T	p.S266F	MQTAGVTGYPRASIARTLRTIVREE	MQTAGVTGYPRAFIARTLRTIVREE	5.0	4.0	-	-	4287_19:19221525-19221525 C>T_MQTAGVTGYPRAFIARTLRTIVREE	0.0
12:32136132-32136132 C>T	0.0	4155	MELANOMA	-	-	-	-	KIAA1551	NM_018169,p.S748L|ENST00000312561,p.S748L|uc001rks.3,p.S748L	retained_intron, protein_coding, processed_transcript	uc001rks.3	nonsynonymous SNV	exon4	c.C2243T	p.S748L	TALSMVMHNYESSGINITKGTELQI	TALSMVMHNYESLGINITKGTELQI	6.0	10.0	-	-	4155_12:32136132-32136132 C>T_TALSMVMHNYESLGINITKGTELQI	0.0
1:235969930-235969930 C>A	1.0	4317	COLORECTAL	-	-	-	-	LYST	NM_000081,p.V836F|uc001hxl.2,p.V836F|uc001hxj.3,p.V836F|ENST00000389793,p.V836F|ENST00000389794,p.V836F|NM_001301365,p.V836F|ENST00000536965,p.V836F	retained_intron, protein_coding, processed_transcript	uc001hxl.2	nonsynonymous SNV	exon6	c.G2506T	p.V836F	IISLGEQQKDASVPDIDGIDIEQKE	IISLGEQQKDASFPDIDGIDIEQKE	7.0	9.0	-	-	4317_1:235969930-235969930 C>A_IISLGEQQKDASFPDIDGIDIEQKE	0.0
19:47424733-47424733 T>G	1.0	4155	MELANOMA	-	-	-	-	ARHGAP35	ENST00000404338,p.F934C|uc010ekv.3,p.F934C|NM_004491,p.F934C	retained_intron, protein_coding, processed_transcript	uc010ekv.3	nonsynonymous SNV	exon1	c.T2801G	p.F934C	IPCSQPQHKLEIFHPFFKDVVEKKN	IPCSQPQHKLEICHPFFKDVVEKKN	8.0	7.0	-	-	4155_19:47424733-47424733 T>G_IPCSQPQHKLEICHPFFKDVVEKKN	0.0
2:73680250-73680250 C>T	0.0	4186	BREAST	-	-	-	-	ALMS1	uc002sjf.1,p.S2156L|uc002sjh.1,p.S1586L|ENST00000377715,p.S2198L|ENST00000423048,p.S476L|uc002sjg.3,p.S1586L|ENST00000264448,p.S2198L|ENST00000409009,p.S2156L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002sjh.1	nonsynonymous SNV	exon1	c.C4757T	p.S1586L	GTYSHGENHKLVSEHVQRLIDNLNS	GTYSHGENHKLVLEHVQRLIDNLNS	6.0	9.0	-	-	4186_2:73680250-73680250 C>T_GTYSHGENHKLVLEHVQRLIDNLNS	0.0
4:119948374-119948374 G>T	0.0	4287	COLORECTAL	-	-	-	-	SYNPO2	NM_133477,p.V284L|ENST00000307142,p.V284L|ENST00000434046,p.V284L|uc003icm.4,p.V284L|uc010ina.3,p.V284L|NM_001286754,p.V253L|NM_001128933,p.V284L|uc010inb.3,p.V284L|uc010inc.3,p.V212L|NM_001128934,p.V284L|ENST00000429713,p.V284L	protein_coding	uc010inc.3	nonsynonymous SNV	exon2	c.G634T	p.V212L	QESEAGDAGLPRVEVILDCSDRQKT	QESEAGDAGLPRLEVILDCSDRQKT	4.0	9.0	-	-	4287_4:119948374-119948374 G>T_QESEAGDAGLPRLEVILDCSDRQKT	0.0
8:3046464-3046464 C>T	0.0	4301	MELANOMA	-	-	-	-	CSMD1	uc011kwj.2,p.G1216E|ENST00000602723,p.G1824E|ENST00000520002,p.G1824E|NM_033225,p.G1823E|ENST00000602557,p.G1824E|ENST00000542608,p.G1823E|ENST00000400186,p.G1824E|uc022aqr.1,p.G1823E|uc003wqe.3,p.G980E|ENST00000537824,p.G1823E|ENST00000539096,p.G1823E	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon35	c.G5468A	p.G1823E	GTILSPGYPEPYGNNLNCIWKIIVT	GTILSPGYPEPYENNLNCIWKIIVT	3.0	1.0	-	-	4301_8:3046464-3046464 C>T_GTILSPGYPEPYENNLNCIWKIIVT	0.0
4:72620224-72620224 C>T	0.0	4196	COLORECTAL	-	-	-	-	GC	ENST00000509740,p.A346T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000509740	nonsynonymous SNV	exon9	c.G1036A	p.A346T	VCDPGNTKVMDKALY	VCDPGNTKVMDKTLY	2.0	10.0	-	-	4196_4:72620224-72620224 C>T_VCDPGNTKVMDKTLY	0.0
7:5428761-5428761 C>A	1.0	4237	NSCLC	-	-	-	-	TNRC18	uc003soi.4,p.A232S|ENST00000430969,p.A232S|uc010ksx.1,p.A158S|NM_001080495,p.A232S|ENST00000399537,p.A232S	retained_intron, protein_coding	uc010ksx.1	nonsynonymous SNV	exon5	c.G472T	p.A158S	FGKKDPRARGEEASGPRGVVDLTQE	FGKKDPRARGEESSGPRGVVDLTQE	10.0	5.0	-	-	4237_7:5428761-5428761 C>A_FGKKDPRARGEESSGPRGVVDLTQE	0.0
8:99441331-99441331 T>A	0.0	4196	COLORECTAL	-	-	-	-	KCNS2	NM_020697,p.V375E|ENST00000287042,p.V375E|uc022azb.1,p.V375E|uc003yin.3,p.V375E|ENST00000521839,p.V375E	protein_coding	uc022azb.1	nonsynonymous SNV	exon1	c.T1124A	p.V375E	ACWWWATVSMTTVGYGDVVPGTTAG	ACWWWATVSMTTEGYGDVVPGTTAG	3.0	7.0	-	-	4196_8:99441331-99441331 T>A_ACWWWATVSMTTEGYGDVVPGTTAG	0.0
7:23830536-23830536 T>G	1.0	4252	COLORECTAL	-	-	-	-	STK31	uc011jze.3,p.L911V|ENST00000433467,p.L911V|NM_001260505,p.L911V	retained_intron, protein_coding, processed_transcript	uc011jze.3	nonsynonymous SNV	exon22	c.T2731G	p.L911V	LKMGKPASPGSDLYAYGCLLLWDDK	LKMGKPASPGSDVYAYGCLLLWDDK	6.0	2.0	-	-	4252_7:23830536-23830536 T>G_LKMGKPASPGSDVYAYGCLLLWDDK	0.0
12:48368041-48368041 G>A	0.0	4298	COLORECTAL	-	-	-	1	COL2A1	ENST00000380518,p.T1383M|NM_033150,p.T1314M|uc001rqv.3,p.T1314M|uc001rqu.3,p.T1383M|ENST00000337299,p.T1314M|NM_001844,p.T1383M|uc001rqt.3,p.T164M	retained_intron, protein_coding, processed_transcript	uc001rqv.3	nonsynonymous SNV	exon52	c.C3941T	p.T1314M	ANVQMTFLRLLSTEGSQNITYHCKN	ANVQMTFLRLLSMEGSQNITYHCKN	4.0	10.0	-	-	4298_12:48368041-48368041 G>A_ANVQMTFLRLLSMEGSQNITYHCKN	0.0
12:41422961-41422961 G>T	0.0	4266	COLORECTAL	-	-	-	-	CNTN1	uc001rmm.2,p.V974L|ENST00000348761,p.V963L|uc031qgz.1,p.V963L|ENST00000347616,p.V974L|ENST00000551295,p.V974L|NM_001843,p.V974L|NM_175038,p.V963L|ENST00000548481,p.V16L	protein_coding, processed_transcript, nonsense_mediated_decay	uc031qgz.1	nonsynonymous SNV	exon21	c.G2887T	p.V963L	IEVPIPRDGEYVVEVRAHSDGGDGV	IEVPIPRDGEYVLEVRAHSDGGDGV	3.0	4.0	-	-	4266_12:41422961-41422961 G>T_IEVPIPRDGEYVLEVRAHSDGGDGV	0.0
16:68010070-68010070 G>A	0.0	4301	MELANOMA	-	-	-	-	DPEP3	NM_022357,p.R411C|uc010cex.3,p.R410C|ENST00000268793,p.R411C|NM_001129758,p.R410C|uc002evc.4,p.R411C	protein_coding, processed_transcript	uc010cex.3	nonsynonymous SNV	exon9	c.C1228T	p.R410C	STYPVLIEELLSRSWSEEELQGVLR	STYPVLIEELLSCSWSEEELQGVLR	4.0	7.0	-	-	4301_16:68010070-68010070 G>A_STYPVLIEELLSCSWSEEELQGVLR	0.0
11:73020968-73020968 C>T	0.0	4345	COLORECTAL	-	-	ID=COSM1356871;OCCURENCE=1(large_intestine)	-	ARHGEF17	ENST00000263674,p.R429W|NM_014786,p.R429W|uc001otu.3,p.R429W	retained_intron, protein_coding, processed_transcript	uc001otu.3	nonsynonymous SNV	exon1	c.C1285T	p.R429W	RSPSFGAGEGLLRSQARTRAKGPGG	RSPSFGAGEGLLWSQARTRAKGPGG	5.0	8.0	-	-	4345_11:73020968-73020968 C>T_RSPSFGAGEGLLWSQARTRAKGPGG	0.0
11:20982103-20982103 G>A	1.0	3784	MELANOMA	-	-	-	-	NELL1	ENST00000298925,p.E461K|ENST00000325319,p.E376K|uc001mqf.3,p.E433K|NM_001288713,p.E461K|uc010rdo.2,p.E376K|NM_201551,p.E433K|uc010rdp.2,p.E193K|NM_001288714,p.E376K|NM_006157,p.E433K|ENST00000532434,p.E433K|uc001mqe.3,p.E433K|ENST00000357134,p.E433K|uc009yid.3,p.E461K	retained_intron, protein_coding, processed_transcript	uc010rdp.2	nonsynonymous SNV	exon9	c.G577A	p.E193K	GYISVQGDSAYCEDIDECAAKMHYC	GYISVQGDSAYCKDIDECAAKMHYC	10.0	1.0	-	-	3784_11:20982103-20982103 G>A_GYISVQGDSAYCKDIDECAAKMHYC	0.0
2:179477691-179477691 T>G	0.0	4213	COLORECTAL	-	-	-	-	TTN	uc031rqc.1,p.Y16586S|uc031rqd.1,p.Y14945S|ENST00000359218,p.Y7646S|ENST00000342175,p.Y7713S|NM_001267550,p.Y16586S|uc021vta.2,p.Y7646S|NM_003319,p.Y7521S|ENST00000591111,p.Y14945S|ENST00000589042,p.Y16586S|NM_001256850,p.Y14945S|ENST00000460472,p.Y7521S|ENST00000342992,p.Y14018S|uc021vsz.2,p.Y7713S|NM_133437,p.Y7713S|uc021vtb.2,p.Y7521S|uc021vsy.2,p.Y14018S|NM_133432,p.Y7646S|NM_133378,p.Y14018S	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon215	c.A44834C	p.Y14945S	KPEHDGGAKIESYVIEMLKTGTDEW	KPEHDGGAKIESSVIEMLKTGTDEW	5.0	10.0	-	-	4213_2:179477691-179477691 T>G_KPEHDGGAKIESSVIEMLKTGTDEW	0.0
1:111491002-111491002 C>G	1.0	4037	NSCLC	-	-	-	-	LRIF1	NM_018372,p.R630T|uc001eab.3,p.R94T|uc001dzz.3,p.R94T|ENST00000485275,p.R94T|NM_001006945,p.R94T|ENST00000494675,p.R94T|ENST00000369763,p.R630T|uc001eaa.3,p.R630T	protein_coding	uc001eab.3	nonsynonymous SNV	exon3	c.G281C	p.R94T	EGERKQQNFDKKRKAKTNKKMDHIK	EGERKQQNFDKKTKAKTNKKMDHIK	7.0	10.0	-	-	4037_1:111491002-111491002 C>G_EGERKQQNFDKKTKAKTNKKMDHIK	0.0
2:15757435-15757435 C>T	1.0	4213	COLORECTAL	-	-	-	-	DDX1	uc010yjq.2,p.S270F|uc021vee.2,p.S281F|ENST00000381341,p.S362F|uc002rce.4,p.S362F|NM_004939,p.S362F|ENST00000233084,p.S362F	retained_intron, protein_coding	uc021vee.2	nonsynonymous SNV	exon11	c.C842T	p.S281F	LDDLVSTGKLNLSQVRFLVLDEADG	LDDLVSTGKLNLFQVRFLVLDEADG	10.0	7.0	CD8	-	4213_2:15757435-15757435 C>T_LDDLVSTGKLNLFQVRFLVLDEADG	1.0
15:81271632-81271632 ->T	1.0	4180	BREAST	-	-	-	-	MESDC2	uc002bfy.1,p.K211fs|ENST00000561312,p.K211fs|ENST00000261758,p.K211fs|NM_015154,p.K211fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc002bfy.1	frameshift insertion	exon3	c.632dupA	p.K211fs	EKNKTKQDKGKKKKEGDLKSRSSKE	EKNKTKQDKGKKKEGRRSEISVFQGRKSSWE	9.0	8.0	-	-	4180_15:81271632-81271632 ->T_EKNKTKQDKGKKKEGRRSEISVFQGRKSSWE	0.0
7:128632137-128632137 G>C	1.0	3775	CERVICAL	-	-	-	-	TNPO3	NM_001191028,p.S425C|ENST00000265388,p.S425C|uc010llz.2,p.S425C|uc003vom.2,p.S359C|ENST00000393245,p.S425C|ENST00000471166,p.S425C|NM_012470,p.S425C|ENST00000471234,p.S425C|uc003vol.2,p.S425C|ENST00000482320,p.S359C|uc010lly.2,p.S425C	protein_coding	uc010llz.2	nonsynonymous SNV	exon10	c.C1274G	p.S425C	LIGSMECFAQLYSTLKEGNPPWEVT	LIGSMECFAQLYCTLKEGNPPWEVT	7.0	10.0	-	-	3775_7:128632137-128632137 G>C_LIGSMECFAQLYCTLKEGNPPWEVT	0.0
10:124402790-124402790 G>A	1.0	4316	COLORECTAL	0.0009	-	-	-	DMBT1	uc001lgm.1,p.R1745H|NM_004406,p.R1745H|ENST00000368956,p.R1745H|uc001lgk.1,p.R2373H|NM_007329,p.R2373H|ENST00000338354,p.R2373H|uc009xzz.1,p.R2372H|ENST00000368955,p.R2363H|ENST00000344338,p.R2363H|ENST00000359586,p.R1093H|uc009yac.1,p.R667H|uc001lgl.1,p.R2363H|uc021qag.1,p.R2363H|NM_017579,p.R2363H|uc021qaf.1,p.R2373H|uc021qah.1,p.R1745H|ENST00000368909,p.R2373H|uc009yab.1,p.R1076H|uc010qtx.1,p.R1093H|ENST00000330163,p.R1745H	protein_coding	uc021qah.1	nonsynonymous SNV	exon40	c.G5234A	p.R1745H	KMVVCRAYDPSSRCYRGCVLRSKRD	KMVVCRAYDPSSHCYRGCVLRSKRD	10.0	9.0	CD8	-	4316_10:124402790-124402790 G>A_KMVVCRAYDPSSHCYRGCVLRSKRD	2.0
20:44519228-44519228 G>A	1.0	3713	MELANOMA	-	-	-	-	NEURL2	NM_080749,p.P135S|NM_001278535,p.P135S|uc002xqg.2,p.P135S|ENST00000372518,p.P135S	protein_coding	uc002xqg.2	nonsynonymous SNV	exon1	c.C403T	p.P135S	PREGRPEAEAAAPSRPPTLLVEPYL	PREGRPEAEAAASSRPPTLLVEPYL	4.0	8.0	-	-	3713_20:44519228-44519228 G>A_PREGRPEAEAAASSRPPTLLVEPYL	0.0
17:11784563-11784563 C>T	1.0	2369	MELANOMA	-	-	-	-	DNAH9	uc010coo.3,p.P2841S|NM_001372,p.P3547S|ENST00000454412,p.P3547S|ENST00000262442,p.P3547S|uc002gne.3,p.P3547S	retained_intron, protein_coding, processed_transcript	uc010coo.3	nonsynonymous SNV	exon43	c.C8521T	p.P2841S	FIKIGDKECEYNPKFRLILHTKLAN	FIKIGDKECEYNSKFRLILHTKLAN	7.0	9.0	-	-	2369_17:11784563-11784563 C>T_FIKIGDKECEYNSKFRLILHTKLAN	0.0
9:111625513-111625513 C>T	0.0	4278	COLORECTAL	-	-	-	-	ACTL7A	ENST00000333999,p.P304L|NM_006687,p.P304L|uc004bdj.1,p.P304L	protein_coding	uc004bdj.1	nonsynonymous SNV	exon1	c.C911T	p.P304L	VPLSEHTIRYVLPDGKEIQLCQERF	VPLSEHTIRYVLLDGKEIQLCQERF	3.0	6.0	-	-	4278_9:111625513-111625513 C>T_VPLSEHTIRYVLLDGKEIQLCQERF	0.0
20:741813-741813 C>T	0.0	3775	CERVICAL	-	-	-	-	SLC52A3	uc002wed.4,p.D423N|NM_033409,p.D423N|ENST00000217254,p.D423N	protein_coding, processed_transcript	uc002wed.4	nonsynonymous SNV	exon5	c.G1267A	p.D423N	SYVKVMLGVVLRDLSRSALLWCGAA	SYVKVMLGVVLRNLSRSALLWCGAA	5.0	10.0	-	-	3775_20:741813-741813 C>T_SYVKVMLGVVLRNLSRSALLWCGAA	0.0
6:143090831-143090831 G>A	1.0	4000	MELANOMA	-	-	-	-	HIVEP2	ENST00000012134,p.P1682L|NM_006734,p.P1682L|ENST00000367603,p.P1682L|uc003qjd.3,p.P1682L|ENST00000367604,p.P1682L	protein_coding, processed_transcript	uc003qjd.3	nonsynonymous SNV	exon5	c.C5045T	p.P1682L	YASWCISSCNPNPSGLNTKTTLALL	YASWCISSCNPNLSGLNTKTTLALL	7.0	4.0	CD8	-	4000_6:143090831-143090831 G>A_YASWCISSCNPNLSGLNTKTTLALL	1.0
2:54877040-54877040 G>A	1.0	4244	COLORECTAL	-	-	-	-	SPTBN1	NM_003128,p.E1831K|uc002rxx.3,p.E1818K|NM_178313,p.E1818K|ENST00000356805,p.E1831K|uc002rxu.3,p.E1831K|ENST00000333896,p.E1818K	retained_intron, protein_coding	uc002rxx.3	nonsynonymous SNV	exon25	c.G5452A	p.E1818K	GRIQDKHKKLPEELGRDQNTVETLQ	GRIQDKHKKLPEKLGRDQNTVETLQ	10.0	5.0	-	-	4244_2:54877040-54877040 G>A_GRIQDKHKKLPEKLGRDQNTVETLQ	0.0
14:77772726-77772726 T>G	1.0	3678	MELANOMA	-	-	-	-	POMT2	uc010asr.2,p.K20T|uc001xti.2,p.K131T|ENST00000554948,p.K40T|NM_013382,p.K131T|ENST00000261534,p.K131T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010asr.2	nonsynonymous SNV	exon2	c.A59C	p.K20T	YLSGYDGTFLFQKPGDKYEHHSYMG	YLSGYDGTFLFQTPGDKYEHHSYMG	9.0	6.0	-	-	3678_14:77772726-77772726 T>G_YLSGYDGTFLFQTPGDKYEHHSYMG	0.0
14:21559195-21559195 C>T	1.0	4287	COLORECTAL	0.0005	-	-	-	ZNF219	NM_016423,p.G557S|NM_001102454,p.G557S|uc001vzs.2,p.G557S|ENST00000360947,p.G557S|ENST00000451119,p.G557S|ENST00000421093,p.G557S|uc001vzr.2,p.G557S|uc010aik.1,p.G557S|NM_001101672,p.G557S	retained_intron, protein_coding, processed_transcript, TEC	uc010aik.1	nonsynonymous SNV	exon5	c.G1669A	p.G557S	LQRHHREQRSGAGPGPPPEPPPPSQ	LQRHHREQRSGASPGPPPEPPPPSQ	5.0	10.0	-	-	4287_14:21559195-21559195 C>T_LQRHHREQRSGASPGPPPEPPPPSQ	0.0
15:67665763-67665763 C>T	0.0	2591	MELANOMA	-	-	-	-	IQCH	uc002aqn.2,p.P282L|NM_001284349,p.P282L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002aqn.2	nonsynonymous SNV	exon7	c.C845T	p.P282L	RIRTSRRTIIHIPSLGITLLPANLS	RIRTSRRTIIHILSLGITLLPANLS	3.0	8.0	-	-	2591_15:67665763-67665763 C>T_RIRTSRRTIIHILSLGITLLPANLS	0.0
1:246720773-246720773 G>A	1.0	4258	ENDOMETRIAL	-	-	-	-	TFB2M	NM_022366,p.P156S|uc001ibn.3,p.P156S|ENST00000366514,p.P156S	protein_coding	uc001ibn.3	nonsynonymous SNV	exon3	c.C466T	p.P156S	LRVIHCDFFKLDPRSGGVIKPPAMS	LRVIHCDFFKLDSRSGGVIKPPAMS	8.0	8.0	-	-	4258_1:246720773-246720773 G>A_LRVIHCDFFKLDSRSGGVIKPPAMS	0.0
16:20696709-20696710 GG>-	0.0	4245	COLORECTAL	-	-	-	-	ACSM1	ENST00000520010,p.P70fs|uc002dhm.1,p.P70fs|ENST00000523065,p.P70fs|NM_052956,p.P70fs|ENST00000307493,p.P70fs|uc010bwg.1,p.P70fs|ENST00000519745,p.P70fs	retained_intron, protein_coding, nonsense_mediated_decay	uc010bwg.1	frameshift deletion	exon3	c.208_209del	p.P70fs	YWAQKEKEGKRGPNPAFWWVNGQGD	YWAQKEKEGKRGKSSFLVGEWPRG	6.0	1.0	-	-	4245_16:20696709-20696710 GG>-_YWAQKEKEGKRGKSSFLVGEWPRG	0.0
6:134493375-134493375 T>A	1.0	4335	COLORECTAL	-	-	-	2	SGK1	ENST00000528577,p.I276F|ENST00000475719,p.I204F|uc003qen.4,p.I248F|NM_005627,p.I248F|NM_001143678,p.I262F|NM_001291995,p.I204F|NM_001143677,p.I276F|NM_001143676,p.I343F|ENST00000367858,p.I343F|uc011ecw.2,p.I276F|ENST00000237305,p.I248F|uc011ecv.2,p.I262F|uc011ect.2,p.I238F|uc003qeo.4,p.I343F|ENST00000413996,p.I262F|ENST00000367857,p.I238F|uc011ecu.2,p.I204F	retained_intron, protein_coding, processed_transcript	uc011ecw.2	nonsynonymous SNV	exon8	c.A826T	p.I276F	IVLTDFGLCKENIEHNSTTSTFCGT	IVLTDFGLCKENFEHNSTTSTFCGT	10.0	8.0	-	-	4335_6:134493375-134493375 T>A_IVLTDFGLCKENFEHNSTTSTFCGT	0.0
12:88390222-88390222 G>A	0.0	4326	BREAST	-	-	-	-	C12orf50	ENST00000298699,p.S137L|ENST00000550553,p.S137L|uc001tam.1,p.S137L|uc001tan.3,p.S191L|NM_152589,p.S137L	protein_coding, processed_transcript	uc001tan.3	nonsynonymous SNV	exon6	c.C572T	p.S191L	YYRFHTPPDILSSKSMTPTAEKQLE	YYRFHTPPDILSLKSMTPTAEKQLE	1.0	9.0	-	-	4326_12:88390222-88390222 G>A_YYRFHTPPDILSLKSMTPTAEKQLE	0.0
19:57022963-57022963 T>G	0.0	4237	NSCLC	-	-	-	-	ZNF471	ENST00000308031,p.V8G|ENST00000591759,p.V8G|uc002qnh.3,p.V8G|ENST00000591537,p.V8G|NM_020813,p.V8G	protein_coding, processed_transcript	uc002qnh.3	nonsynonymous SNV	exon2	c.T23G	p.V8G	MNVEVVKVMPQDLVTFKDVA	MNVEVVKGMPQDLVTFKDVA	6.0	9.0	-	-	4237_19:57022963-57022963 T>G_MNVEVVKGMPQDLVTFKDVA	0.0
13:32977299-32977299 C>T	1.0	4346	COLORECTAL	-	-	-	-	N4BP2L1	NM_001286459,p.R171Q|ENST00000380130,p.R171Q|NM_052818,p.R171Q|ENST00000530622,p.R65Q|uc001uuc.3,p.R171Q|ENST00000380133,p.R171Q	protein_coding, processed_transcript	uc001uuc.3	nonsynonymous SNV	exon5	c.G512A	p.R171Q	RNIHGVSREKIHRMKERYEHDVTFH	RNIHGVSREKIHQMKERYEHDVTFH	7.0	2.0	-	-	4346_13:32977299-32977299 C>T_RNIHGVSREKIHQMKERYEHDVTFH	0.0
3:52088115-52088115 C>T	1.0	4287	COLORECTAL	-	-	-	-	DUSP7	uc010hma.2,p.V265M|ENST00000296483,p.V214M|ENST00000495880,p.V265M|ENST00000469623,p.V198M|NM_001947,p.V265M|uc003dct.3,p.V265M	protein_coding	uc010hma.2	nonsynonymous SNV	exon2	c.G793A	p.V265M	YLGCAKDSTNLDVLGKYGIKYILNV	YLGCAKDSTNLDMLGKYGIKYILNV	5.0	4.0	-	-	4287_3:52088115-52088115 C>T_YLGCAKDSTNLDMLGKYGIKYILNV	0.0
1:18809325-18809325 C>A	0.0	4046	OVARIAN	-	-	-	-	KLHDC7A	uc001bax.3,p.P617Q|NM_152375,p.P617Q|uc009vpg.3,p.P399Q|ENST00000400664,p.P617Q	protein_coding	uc009vpg.3	nonsynonymous SNV	exon1	c.C1196A	p.P399Q	YDPRLDRWDFAPPLPSDTFALAHTA	YDPRLDRWDFAPQLPSDTFALAHTA	4.0	7.0	-	-	4046_1:18809325-18809325 C>A_YDPRLDRWDFAPQLPSDTFALAHTA	0.0
20:50701316-50701316 T>A	1.0	4320	COLORECTAL	-	-	-	-	ZFP64	ENST00000361387,p.K573M|ENST00000371523,p.K354M|NM_199427,p.K573M|uc002xwk.3,p.K573M|uc002xwj.3,p.K354M	protein_coding, processed_transcript	uc002xwk.3	nonsynonymous SNV	exon9	c.A1718T	p.K573M	EGLREGSSQHVAKIVTQRAFRCETC	EGLREGSSQHVAMIVTQRAFRCETC	9.0	7.0	-	-	4320_20:50701316-50701316 T>A_EGLREGSSQHVAMIVTQRAFRCETC	0.0
5:93872730-93872730 A>C	1.0	3879	MELANOMA	-	-	-	-	KIAA0825	NM_173665,p.I34M|uc011cuk.2,p.I34M|NM_001145678,p.I34M|ENST00000427991,p.I34M|uc003kkp.2,p.I34M|ENST00000329378,p.I34M|ENST00000513200,p.I34M|ENST00000312498,p.I34M	retained_intron, protein_coding, processed_transcript	uc011cuk.2	nonsynonymous SNV	exon3	c.T102G	p.I34M	PGDLEFEQIFSDIDEKIEQNAASIK	PGDLEFEQIFSDMDEKIEQNAASIK	4.0	5.0	-	-	3879_5:93872730-93872730 A>C_PGDLEFEQIFSDMDEKIEQNAASIK	0.0
15:42113073-42113073 A>C	0.0	4335	COLORECTAL	-	-	-	-	MAPKBP1	ENST00000221214,p.N725T|uc010bci.3,p.N842T|NM_014994,p.N842T|NM_001128608,p.N848T|NM_001265611,p.N842T|ENST00000456763,p.N848T|ENST00000457542,p.N842T|uc010bcj.3,p.N349T|uc010bck.3,p.N59T|ENST00000514566,p.N842T|uc010bcl.3,p.N349T|uc010udb.2,p.N681T|uc001zoj.4,p.N842T|uc001zok.4,p.N848T|ENST00000260357,p.N681T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010udb.2	nonsynonymous SNV	exon21	c.A2042C	p.N681T	ESVGFLDPAPAANPGPRRRGRWVQP	ESVGFLDPAPAATPGPRRRGRWVQP	6.0	3.0	-	-	4335_15:42113073-42113073 A>C_ESVGFLDPAPAATPGPRRRGRWVQP	0.0
19:6415664-6415664 G>A	1.0	4000	MELANOMA	-	-	-	-	KHSRP	NM_003685,p.P590L|uc002mer.4,p.P590L|ENST00000398148,p.P590L	retained_intron, protein_coding	uc002mer.4	nonsynonymous SNV	exon17	c.C1769T	p.P590L	AYYSHYYQQPPGPVPGPAPAPAAPP	AYYSHYYQQPPGLVPGPAPAPAAPP	10.0	10.0	-	-	4000_19:6415664-6415664 G>A_AYYSHYYQQPPGLVPGPAPAPAAPP	0.0
1:115398147-115398147 C>T	0.0	4301	MELANOMA	-	-	-	-	SYCP1	uc009wgw.3,p.S21F|ENST00000369522,p.S21F|ENST00000369518,p.S21F|uc001efq.3,p.S21F|NM_001282541,p.S21F|NM_001282542,p.S21F|ENST00000455987,p.S21F|NM_003176,p.S21F|uc001efr.3,p.S21F	protein_coding, processed_transcript	uc009wgw.3	nonsynonymous SNV	exon2	c.C62T	p.S21F	LFVPPRSSSSQVSAVKPQTLGGDST	LFVPPRSSSSQVFAVKPQTLGGDST	1.0	1.0	-	-	4301_1:115398147-115398147 C>T_LFVPPRSSSSQVFAVKPQTLGGDST	0.0
7:103138360-103138360 A>T	0.0	4046	OVARIAN	-	-	-	-	RELN	NM_173054,p.W2953R|uc022ajr.1,p.W2953R|ENST00000343529,p.W2953R|ENST00000424685,p.W2953R|ENST00000428762,p.W2953R|NM_005045,p.W2953R|uc010liz.3,p.W2953R|uc022ajq.1,p.W2953R	retained_intron, protein_coding, processed_transcript	uc022ajr.1	nonsynonymous SNV	exon55	c.T8857A	p.W2953R	DLDLRGAKFLQYWGRIGSENNMTSC	DLDLRGAKFLQYRGRIGSENNMTSC	4.0	4.0	-	-	4046_7:103138360-103138360 A>T_DLDLRGAKFLQYRGRIGSENNMTSC	0.0
7:111418403-111418403 T>C	0.0	4238	COLORECTAL	-	-	-	-	DOCK4	ENST00000437633,p.N1194S|NM_014705,p.N1194S|ENST00000428084,p.N1203S|ENST00000417165,p.N101S|uc011kml.2,p.N75S|uc011kmm.2,p.N101S|ENST00000494651,p.N77S|ENST00000450156,p.N77S|uc003vfw.3,p.N644S|ENST00000437129,p.N68S|uc003vfx.3,p.N1194S|uc003vfy.3,p.N1239S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kmm.2	nonsynonymous SNV	exon5	c.A302G	p.N101S	TVSLLNFYKTELNKEEMYIRYIHKL	TVSLLNFYKTELSKEEMYIRYIHKL	2.0	2.0	-	-	4238_7:111418403-111418403 T>C_TVSLLNFYKTELSKEEMYIRYIHKL	0.0
17:35563743-35563743 G>A	1.0	3713	MELANOMA	-	-	-	-	ACACA	uc002hnk.3,p.P1186L|NM_198836,p.P1264L|ENST00000394406,p.P1264L|uc002hnl.3,p.P1206L|NM_198834,p.P1301L|uc002hnm.3,p.P1264L|NM_198838,p.P1186L|ENST00000335166,p.P1186L|ENST00000360679,p.P1206L|NM_198839,p.P1264L|uc002hno.3,p.P1301L|ENST00000353139,p.P1301L|NM_198837,p.P1206L|uc002hnn.3,p.P1264L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc002hno.3	nonsynonymous SNV	exon32	c.C3902T	p.P1301L	VMGCFSDSPPQSPTFPEAGHTSLYD	VMGCFSDSPPQSLTFPEAGHTSLYD	5.0	10.0	-	-	3713_17:35563743-35563743 G>A_VMGCFSDSPPQSLTFPEAGHTSLYD	0.0
22:38083977-38083977 G>T	1.0	4317	COLORECTAL	-	-	-	-	NOL12	NM_024313,p.E48D|uc011anm.1,p.E48D|ENST00000438329,p.E48D|ENST00000359114,p.E48D|uc003atp.3,p.E48D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011anm.1	nonsynonymous SNV	exon2	c.G144T	p.E48D	KRKVERKKAAIEEIKQRLKEEQRKL	KRKVERKKAAIEDIKQRLKEEQRKL	9.0	9.0	-	-	4317_22:38083977-38083977 G>T_KRKVERKKAAIEDIKQRLKEEQRKL	0.0
1:148024720-148024720 G>T	1.0	4071	COLORECTAL	-	-	-	-	NBPF8	uc001eqf.4,p.L433I|NM_001037501,p.L433I|ENST00000369219,p.L93I|uc001eqq.3,p.L93I	protein_coding	uc001eqq.3	nonsynonymous SNV	exon2	c.C277A	p.L93I	EGCRLAQHLVQKLSPENDNDDDEDV	EGCRLAQHLVQKISPENDNDDDEDV	8.0	1.0	-	-	4071_1:148024720-148024720 G>T_EGCRLAQHLVQKISPENDNDDDEDV	0.0
4:90035222-90035222 T>-	1.0	4046	OVARIAN	-	-	-	-	TIGD2	uc003hsk.3,p.I366fs|ENST00000317005,p.I366fs|NM_145715,p.I366fs	protein_coding	uc003hsk.3	frameshift deletion	exon1	c.1097delT	p.I366fs	KIFWKNLTVLDAIYEVSRAWNMVKS	KIFWKNLTVLDAIMKCQELGTW	6.0	8.0	-	-	4046_4:90035222-90035222 T>-_KIFWKNLTVLDAIMKCQELGTW	0.0
19:5265166-5265166 G>A	1.0	2359	MELANOMA	-	-	ID=COSM142761;OCCURENCE=1(skin)	-	PTPRS	ENST00000588012,p.P141S|uc002mby.3,p.P141S|NM_130853,p.P141S|uc002mbw.3,p.P141S|ENST00000587303,p.P141S|uc002mbv.3,p.P141S|ENST00000372412,p.P141S|ENST00000348075,p.P141S|ENST00000262963,p.P141S|NM_130855,p.P141S|NM_130854,p.P141S|NM_002850,p.P141S|ENST00000353284,p.P141S|ENST00000592099,p.P141S|ENST00000357368,p.P141S|uc002mbu.1,p.P141S|uc010xin.2,p.P141S|uc002mbx.3,p.P141S	retained_intron, protein_coding, processed_transcript	uc010xin.2	nonsynonymous SNV	exon4	c.C421T	p.P141S	QLPSGFPNIDMGPQLKVVERTRTAT	QLPSGFPNIDMGSQLKVVERTRTAT	8.0	6.0	-	-	2359_19:5265166-5265166 G>A_QLPSGFPNIDMGSQLKVVERTRTAT	0.0
8:69017518-69017518 C>T	0.0	3903	MELANOMA	-	-	-	1	PREX2	uc003xxu.1,p.S954F|NM_025170,p.S954F	protein_coding, processed_transcript	uc003xxu.1	nonsynonymous SNV	exon24	c.C2861T	p.S954F	EFLLLPPPLLGISQDGRQHCIPEDL	EFLLLPPPLLGIFQDGRQHCIPEDL	3.0	8.0	-	-	3903_8:69017518-69017518 C>T_EFLLLPPPLLGIFQDGRQHCIPEDL	0.0
17:78704453-78704453 T>G	1.0	4245	COLORECTAL	-	-	-	-	RPTOR	ENST00000537330,p.L16V|uc010wuf.1,p.L16V|ENST00000570891,p.L201V|ENST00000544334,p.L201V|uc002jys.3,p.L201V|uc002jyt.1,p.L201V|uc010wug.1,p.L201V|ENST00000306801,p.L201V|NM_020761,p.L201V|NM_001163034,p.L201V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wug.1	nonsynonymous SNV	exon5	c.T601G	p.L201V	PSIFVYDCSNAGLIVKSFKQFALQR	PSIFVYDCSNAGVIVKSFKQFALQR	7.0	5.0	-	-	4245_17:78704453-78704453 T>G_PSIFVYDCSNAGVIVKSFKQFALQR	0.0
7:71175788-71175788 C>A	0.0	4259	COLORECTAL	-	-	-	-	WBSCR17	uc003tvy.4,p.L515M|NM_022479,p.L515M|uc003tvz.4,p.L214M|ENST00000333538,p.L515M	protein_coding, processed_transcript	uc003tvz.4	nonsynonymous SNV	exon10	c.C640A	p.L214M	RYTKEGFLHLGALGTTTLLPDTRCL	RYTKEGFLHLGAMGTTTLLPDTRCL	4.0	7.0	-	-	4259_7:71175788-71175788 C>A_RYTKEGFLHLGAMGTTTLLPDTRCL	0.0
3:178968705-178968705 G>A	1.0	3775	CERVICAL	-	-	-	-	KCNMB3	uc003fjo.3,p.S7L|ENST00000392686,p.S7L|ENST00000485523,p.S7L|NM_171829,p.S7L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fjo.3	nonsynonymous SNV	exon2	c.C20T	p.S7L	MTAFPASGKKRETDYSDGD	MTAFPALGKKRETDYSDGD	6.0	10.0	-	-	3775_3:178968705-178968705 G>A_MTAFPALGKKRETDYSDGD	0.0
X:47101515-47101515 G>A	0.0	4196	COLORECTAL	-	-	-	-	USP11	NM_004651,p.R448Q|uc004dhp.3,p.R448Q|ENST00000218348,p.R448Q|uc004dhq.3,p.R175Q|ENST00000377107,p.R405Q	retained_intron, protein_coding	uc004dhq.3	nonsynonymous SNV	exon8	c.G524A	p.R175Q	QEVAQEAWQNHKRRNDSVIVDTFHG	QEVAQEAWQNHKQRNDSVIVDTFHG	9.0	3.0	-	-	4196_X:47101515-47101515 G>A_QEVAQEAWQNHKQRNDSVIVDTFHG	0.0
5:140347642-140347642 C>T	0.0	4266	COLORECTAL	-	-	ID=COSM1434084;OCCURENCE=1(large_intestine)	-	PCDHAC2	NM_031883,p.R431W|ENST00000289269,p.R431W|uc011dag.2,p.R431W|uc003lii.3,p.R431W|NM_018899,p.R431W	protein_coding	uc011dag.2	nonsynonymous SNV	exon1	c.C1291T	p.R431W	YTLVVSGPLDRERVAVYNITVTATD	YTLVVSGPLDREWVAVYNITVTATD	2.0	10.0	-	-	4266_5:140347642-140347642 C>T_YTLVVSGPLDREWVAVYNITVTATD	0.0
1:40705103-40705103 A>C	0.0	4316	COLORECTAL	-	-	-	-	RLF	NM_012421,p.S1577R|uc001cfc.4,p.S1577R|ENST00000372771,p.S1577R|uc001cfd.4,p.S1268R	protein_coding, processed_transcript	uc001cfd.4	nonsynonymous SNV	exon2	c.A3802C	p.S1268R	SIVRHYKRTHQMSSAYLEQQMENLV	SIVRHYKRTHQMRSAYLEQQMENLV	5.0	1.0	-	-	4316_1:40705103-40705103 A>C_SIVRHYKRTHQMRSAYLEQQMENLV	0.0
11:18158850-18158850 C>T	0.0	4213	COLORECTAL	-	-	ID=COSM428778;OCCURENCE=1(breast)	-	MRGPRX3	ENST00000531264,p.T34M|NM_054031,p.T34M|ENST00000396275,p.T34M|uc021qek.1,p.T34M|uc001mnu.3,p.T34M	protein_coding	uc021qek.1	nonsynonymous SNV	exon1	c.C101T	p.T34M	PCYKQTLSFTGLTCIVSLVALTGNA	PCYKQTLSFTGLMCIVSLVALTGNA	1.0	9.0	-	-	4213_11:18158850-18158850 C>T_PCYKQTLSFTGLMCIVSLVALTGNA	0.0
2:33572443-33572443 A>T	1.0	4244	COLORECTAL	-	-	-	-	LTBP1	ENST00000422669,p.E125V|NM_001166264,p.E921V|uc010ymz.2,p.E921V|ENST00000418533,p.E921V|uc010ynb.2,p.E187V|NM_001166266,p.E868V|ENST00000272273,p.E187V|uc010yna.2,p.E868V	protein_coding, processed_transcript	uc010ynb.2	nonsynonymous SNV	exon7	c.A560T	p.E187V	ISADGRTCEDVNECELLSGVCGEAF	ISADGRTCEDVNVCELLSGVCGEAF	9.0	9.0	-	-	4244_2:33572443-33572443 A>T_ISADGRTCEDVNVCELLSGVCGEAF	0.0
15:79382744-79382744 T>A	0.0	4078	GASTRIC	-	-	-	-	RASGRF1	uc002beq.3,p.S33C|uc002bep.3,p.S33C|NM_002891,p.S33C|NM_001145648,p.S33C|ENST00000419573,p.S33C|ENST00000558480,p.S33C|uc002ber.4,p.S33C	retained_intron, protein_coding, processed_transcript, TEC	uc002ber.4	nonsynonymous SNV	exon1	c.A97T	p.S33C	KDGTRKGYLSKRSSDNTKWQTKWFA	KDGTRKGYLSKRCSDNTKWQTKWFA	4.0	2.0	-	-	4078_15:79382744-79382744 T>A_KDGTRKGYLSKRCSDNTKWQTKWFA	0.0
16:904648-904648 C>T	1.0	4329	COLORECTAL	-	-	-	-	LMF1	ENST00000262301,p.A530T|ENST00000399843,p.A530T|uc010uuu.2,p.A313T|uc021tae.1,p.A530T|NM_022773,p.A530T|uc002ckk.2,p.A313T|ENST00000543238,p.A293T|ENST00000568897,p.A313T|uc010bri.2,p.A293T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, TEC	uc021tae.1	nonsynonymous SNV	exon11	c.G1588A	p.A530T	RYKFSRPGGRHAAEGKWWVRKRIGA	RYKFSRPGGRHATEGKWWVRKRIGA	7.0	9.0	-	-	4329_16:904648-904648 C>T_RYKFSRPGGRHATEGKWWVRKRIGA	0.0
8:143784578-143784578 A>C	0.0	4298	COLORECTAL	-	-	-	-	LY6K	ENST00000292430,p.K96T|ENST00000561179,p.K154T|NM_017527,p.K96T|uc011ljv.2,p.K96T	protein_coding, processed_transcript	uc011ljv.2	nonsynonymous SNV	exon3	c.A287C	p.K96T	QCSAGCAAMERPKPEEKRFLLEEPM	QCSAGCAAMERPTPEEKRFLLEEPM	3.0	3.0	-	-	4298_8:143784578-143784578 A>C_QCSAGCAAMERPTPEEKRFLLEEPM	0.0
15:101853605-101853605 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	PCSK6	ENST00000398185,p.G720D|ENST00000358417,p.G878D|uc010bpd.3,p.G688D|ENST00000348070,p.G891D	retained_intron, protein_coding, processed_transcript	uc010bpd.3	nonsynonymous SNV	exon17	c.G2063A	p.G688D	ACGEGFYPEEMPGLPHKVCRRCDEN	ACGEGFYPEEMPDLPHKVCRRCDEN	5.0	3.0	-	-	4258_15:101853605-101853605 C>T_ACGEGFYPEEMPDLPHKVCRRCDEN	0.0
12:53646663-53646663 C>T	1.0	2369	MELANOMA	-	-	-	-	MFSD5	ENST00000329548,p.S15F|uc001sch.2,p.S122F|uc001sci.2,p.S15F|NM_001170790,p.S122F|ENST00000551660,p.S122F|ENST00000534842,p.S122F|uc021qye.1,p.S15F|NM_032889,p.S15F	protein_coding, processed_transcript	uc021qye.1	nonsynonymous SNV	exon1	c.C44T	p.S15F	VTAYLAFVGLLASCLGLELSRCRAK	VTAYLAFVGLLAFCLGLELSRCRAK	9.0	10.0	-	-	2369_12:53646663-53646663 C>T_VTAYLAFVGLLAFCLGLELSRCRAK	0.0
11:6661884-6661884 C>T	1.0	2369	MELANOMA	-	-	-	-	DCHS1	NM_003737,p.D321N|ENST00000299441,p.D321N|uc001mem.1,p.D321N	protein_coding	uc001mem.1	nonsynonymous SNV	exon2	c.G961A	p.D321N	AHTGLLQLERPLDFEQRRVHELVVQ	AHTGLLQLERPLNFEQRRVHELVVQ	5.0	4.0	-	-	2369_11:6661884-6661884 C>T_AHTGLLQLERPLNFEQRRVHELVVQ	0.0
9:100193303-100193303 G>A	1.0	4345	COLORECTAL	-	-	-	-	TDRD7	ENST00000355295,p.R99H|NM_014290,p.R99H|uc004axj.3,p.R99H|uc011lux.2,p.R25H|ENST00000422139,p.R25H	protein_coding, processed_transcript	uc011lux.2	nonsynonymous SNV	exon2	c.G74A	p.R25H	VARQRSSKRKTGRQVNCQMRVKKTM	VARQRSSKRKTGHQVNCQMRVKKTM	7.0	10.0	-	-	4345_9:100193303-100193303 G>A_VARQRSSKRKTGHQVNCQMRVKKTM	0.0
22:39909639-39909639 C>T	1.0	3879	MELANOMA	-	-	-	-	MIEF1	ENST00000404569,p.R235C|uc003axy.3,p.R57C|uc003axw.3,p.R235C|ENST00000402881,p.R235C|ENST00000325301,p.R235C|uc003axx.3,p.R235C|uc010gxz.1,p.R57C|NM_019008,p.R235C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010gxz.1	nonsynonymous SNV	exon7	c.C169T	p.R57C	TIMNVPGFFLVRRENPEYFPRGSSY	TIMNVPGFFLVRCENPEYFPRGSSY	9.0	7.0	-	-	3879_22:39909639-39909639 C>T_TIMNVPGFFLVRCENPEYFPRGSSY	0.0
12:62931482-62931482 T>G	1.0	4320	COLORECTAL	-	-	-	-	MON2	ENST00000552738,p.L682R|ENST00000393629,p.L705R|uc010ssn.2,p.L705R|NM_001278471,p.L682R|ENST00000393632,p.L705R|NM_001278472,p.L633R|ENST00000552115,p.L705R|uc010ssm.2,p.L682R|NM_015026,p.L705R|NM_001278469,p.L705R|ENST00000546600,p.L705R|uc009zqj.3,p.L705R|uc010ssl.2,p.L633R|NM_001278470,p.L705R|ENST00000393630,p.L705R|ENST00000280379,p.L705R|uc001sre.3,p.L705R|uc001srf.3,p.L468R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ssn.2	nonsynonymous SNV	exon16	c.T2114G	p.L705R	VLGTSWQLVLATLQHLVWILGLKPS	VLGTSWQLVLATRQHLVWILGLKPS	8.0	5.0	-	-	4320_12:62931482-62931482 T>G_VLGTSWQLVLATRQHLVWILGLKPS	0.0
1:37356668-37356668 T>C	0.0	4329	COLORECTAL	-	-	-	-	GRIK3	ENST00000373091,p.N49D|ENST00000373093,p.N49D|uc001caz.2,p.N49D|NM_000831,p.N49D|uc001cba.1,p.N49D	protein_coding, processed_transcript	uc001cba.1	nonsynonymous SNV	exon2	c.A145G	p.N49D	RIGGIFEYADGPNAQVMNAEEHAFR	RIGGIFEYADGPDAQVMNAEEHAFR	1.0	8.0	-	-	4329_1:37356668-37356668 T>C_RIGGIFEYADGPDAQVMNAEEHAFR	0.0
10:133058539-133058539 C>T	0.0	4298	COLORECTAL	-	-	-	-	TCERG1L	NM_174937,p.R280Q|uc001lkp.3,p.R280Q|ENST00000368642,p.R280Q	retained_intron, protein_coding	uc001lkp.3	nonsynonymous SNV	exon4	c.G839A	p.R280Q	HFLTLAPIKIPLRTSPVSDTRTERG	HFLTLAPIKIPLQTSPVSDTRTERG	1.0	10.0	-	-	4298_10:133058539-133058539 C>T_HFLTLAPIKIPLQTSPVSDTRTERG	0.0
3:98073226-98073226 T>G	0.0	4346	COLORECTAL	-	-	-	-	OR5K4	uc011bgv.2,p.F177V|ENST00000354924,p.F177V|NM_001005517,p.F177V	protein_coding	uc011bgv.2	nonsynonymous SNV	exon1	c.T529G	p.F177V	RLTFCRSNKIHHFFCDILPLYRLSC	RLTFCRSNKIHHVFCDILPLYRLSC	1.0	4.0	-	-	4346_3:98073226-98073226 T>G_RLTFCRSNKIHHVFCDILPLYRLSC	0.0
X:140994634-140994634 G>C	0.0	4177	PANCREATIC	-	-	-	-	MAGEC1	NM_005462,p.V482L|uc004fbt.3,p.V482L|ENST00000285879,p.V482L|uc022cfi.1,p.V141L	protein_coding	uc022cfi.1	nonsynonymous SNV	exon1	c.G421C	p.V141L	FEGFPQSPLQIPVSSSSSSSTLLSL	FEGFPQSPLQIPLSSSSSSSTLLSL	1.0	4.0	-	-	4177_X:140994634-140994634 G>C_FEGFPQSPLQIPLSSSSSSSTLLSL	0.0
16:28493442-28493442 G>A	1.0	3919	MELANOMA	-	-	-	-	CLN3	uc002dpm.3,p.A293V|ENST00000565316,p.A330V|ENST00000357857,p.A293V|ENST00000357806,p.A248V|ENST00000569430,p.A347V|ENST00000355477,p.A299V|ENST00000568224,p.A269V|uc002dpo.3,p.A347V|uc010vcv.2,p.A323V|ENST00000535392,p.A269V|uc002dpu.1,p.A245V|uc002dpq.1,p.A299V|ENST00000333496,p.A323V|uc002dpp.3,p.A347V|NM_001286110,p.A293V|uc002dps.1,p.A220V|uc002dpt.1,p.A247V|ENST00000354630,p.A330V|ENST00000359984,p.A347V|uc010bye.1,p.A330V|NM_001286105,p.A247V|ENST00000360019,p.A347V|uc010vcu.2,p.A247V|uc021tfs.1,p.A194V|uc002dpl.3,p.A269V|NM_001286109,p.A269V|NM_001042432,p.A347V|NM_000086,p.A347V|NM_001286104,p.A323V|ENST00000395653,p.A247V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tfs.1	nonsynonymous SNV	exon8	c.C581T	p.A194V	SSLRCCRIRFTWALALLQCLNLVFL	SSLRCCRIRFTWVLALLQCLNLVFL	7.0	5.0	-	-	3919_16:28493442-28493442 G>A_SSLRCCRIRFTWVLALLQCLNLVFL	0.0
16:30495230-30495230 G>A	0.0	2359	MELANOMA	-	-	ID=COSM3817792;OCCURENCE=1(breast)	-	ITGAL	uc002dyj.4,p.D186N|ENST00000356798,p.D269N|NM_001114380,p.D186N|ENST00000358164,p.D186N|ENST00000564118,p.D186N|NM_002209,p.D269N|uc002dyi.4,p.D269N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dyj.4	nonsynonymous SNV	exon6	c.G556A	p.D186N	KVLIIITDGEATDSGNIDAAKDIIR	KVLIIITDGEATNSGNIDAAKDIIR	3.0	1.0	-	-	2359_16:30495230-30495230 G>A_KVLIIITDGEATNSGNIDAAKDIIR	0.0
10:120085701-120085701 C>G	1.0	4258	ENDOMETRIAL	-	-	-	-	FAM204A	ENST00000470476,p.A170P	protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000470476	nonsynonymous SNV	exon6	c.G508C	p.A170P	IDQAVEEWNIEKAEELSNQLATREE	IDQAVEEWNIEKPEELSNQLATREE	8.0	10.0	-	-	4258_10:120085701-120085701 C>G_IDQAVEEWNIEKPEELSNQLATREE	0.0
5:140778884-140778884 C>T	1.0	3879	MELANOMA	-	-	-	-	PCDHGB5	NM_032099,p.S397L|NM_018925,p.S397L|uc003lkf.2,p.S397L|uc011daw.2,p.S397L	protein_coding	uc011daw.2	nonsynonymous SNV	exon1	c.C1190T	p.S397L	EVPFKIISSSKNSYKLVTDGTLDRE	EVPFKIISSSKNLYKLVTDGTLDRE	5.0	3.0	-	-	3879_5:140778884-140778884 C>T_EVPFKIISSSKNLYKLVTDGTLDRE	0.0
X:138684594-138684594 T>A	0.0	4245	COLORECTAL	-	-	-	-	MCF2	ENST00000370576,p.R603W|ENST00000519895,p.R679W|ENST00000370578,p.R748W|uc004fav.3,p.R619W|NM_001171876,p.R679W|NM_001171879,p.R619W|ENST00000414978,p.R663W|ENST00000520602,p.R663W|NM_005369,p.R603W|NM_001171877,p.R564W|uc010nsh.2,p.R603W|NM_001171878,p.R603W|ENST00000338585,p.R619W|ENST00000536274,p.R564W|NM_001099855,p.R663W|uc004faw.2,p.R663W|uc011mwm.2,p.R564W|uc011mwo.1,p.R679W|uc004fau.3,p.R603W|ENST00000446225,p.R206W|ENST00000370573,p.R603W|uc011mwl.2,p.R580W|uc011mwn.1,p.R748W	protein_coding, processed_transcript	uc011mwo.1	nonsynonymous SNV	exon20	c.A2035T	p.R679W	YCQNKPRSETIWRKYSECAFFQECQ	YCQNKPRSETIWWKYSECAFFQECQ	2.0	10.0	-	-	4245_X:138684594-138684594 T>A_YCQNKPRSETIWWKYSECAFFQECQ	0.0
19:22575731-22575731 A>T	0.0	4110	BILE DUCT	-	-	ID=COSM303657,COSM303658;OCCURENCE=1(central_nervous_system),1(large_intestine)	-	ZNF98	uc002nqt.2,p.N102K|ENST00000593657,p.N61K|NM_001098626,p.N102K|ENST00000357774,p.N102K	protein_coding, processed_transcript	uc002nqt.2	nonsynonymous SNV	exon4	c.T306A	p.N102K	FAQDLWPKQGKKNYFQKVILRTYKK	FAQDLWPKQGKKKYFQKVILRTYKK	4.0	10.0	-	-	4110_19:22575731-22575731 A>T_FAQDLWPKQGKKKYFQKVILRTYKK	0.0
19:49611286-49611286 G>C	1.0	4240	BREAST	-	-	-	-	SNRNP70	uc002pmh.3,p.G78A|uc021uxh.1,p.G87A	retained_intron, protein_coding, nonsense_mediated_decay	uc021uxh.1	nonsynonymous SNV	exon4	c.G260C	p.G87A	GSGEAAGVGSGPGGSGSARRSCVAA	GSGEAAGVGSGPAGSGSARRSCVAA	10.0	4.0	-	-	4240_19:49611286-49611286 G>C_GSGEAAGVGSGPAGSGSARRSCVAA	0.0
19:1063657-1063657 G>T	1.0	4234	NSCLC	-	-	-	-	ABCA7	ENST00000433129,p.D1943Y|uc002lqy.3,p.D396Y|ENST00000263094,p.D1943Y|uc002lqw.4,p.D1943Y|NM_019112,p.D1943Y|ENST00000435683,p.D1805Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002lqy.3	nonsynonymous SNV	exon10	c.G1186T	p.D396Y	KRKLATALALVGDPAVVFLDEPTTG	KRKLATALALVGYPAVVFLDEPTTG	8.0	10.0	-	-	4234_19:1063657-1063657 G>T_KRKLATALALVGYPAVVFLDEPTTG	0.0
1:16256061-16256061 C>T	1.0	3713	MELANOMA	-	-	-	1	SPEN	ENST00000375759,p.S1109L|uc010obp.1,p.S1068L|uc001axk.1,p.S1109L|NM_015001,p.S1109L	protein_coding, processed_transcript	uc010obp.1	nonsynonymous SNV	exon10	c.C3203T	p.S1068L	ENQEVQSKKPIPSKPQLKQLQVLDD	ENQEVQSKKPIPLKPQLKQLQVLDD	8.0	9.0	-	-	3713_1:16256061-16256061 C>T_ENQEVQSKKPIPLKPQLKQLQVLDD	0.0
5:139494012-139494012 G>C	1.0	4126	NSCLC	-	-	-	-	PURA	ENST00000331327,p.K82N|NM_005859,p.K82N|uc003lfa.3,p.K82N	protein_coding, processed_transcript	uc003lfa.3	nonsynonymous SNV	exon1	c.G246C	p.K82N	NKRFYLDVKQNAKGRFLKIAEVGAG	NKRFYLDVKQNANGRFLKIAEVGAG	8.0	3.0	-	-	4126_5:139494012-139494012 G>C_NKRFYLDVKQNANGRFLKIAEVGAG	0.0
1:55161057-55161057 T>C	1.0	4278	COLORECTAL	-	-	-	-	MROH7	ENST00000339553,p.V953A|ENST00000395690,p.V953A|ENST00000409996,p.V521A|NM_001039464,p.V953A|uc010ood.1,p.V471A|uc010oog.1,p.V953A|uc001cxu.3,p.V99A|uc009vzr.1,p.V155A|ENST00000421030,p.V953A|ENST00000454855,p.V471A|NM_001291332,p.V471A|ENST00000414150,p.V953A|uc010ooe.1,p.V953A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010oog.1	nonsynonymous SNV	exon15	c.T2858C	p.V953A	HHRGVALLARAMVQYSCQELCRILY	HHRGVALLARAMAQYSCQELCRILY	5.0	10.0	-	-	4278_1:55161057-55161057 T>C_HHRGVALLARAMAQYSCQELCRILY	0.0
10:122273430-122273430 C>T	1.0	3466	MELANOMA	-	-	-	-	PPAPDC1A	uc010qtd.2,p.S58F|uc001lev.1,p.S58F|NM_001030059,p.S58F|ENST00000541332,p.S58F|ENST00000427079,p.S58F|ENST00000369073,p.S48F|ENST00000439221,p.S58F|ENST00000398250,p.S58F|uc009xzl.1,p.S58F	protein_coding, processed_transcript	uc010qtd.2	nonsynonymous SNV	exon3	c.C173T	p.S58F	SDNIPTRLMFAISFLTPLAVICVVK	SDNIPTRLMFAIFFLTPLAVICVVK	7.0	5.0	-	-	3466_10:122273430-122273430 C>T_SDNIPTRLMFAIFFLTPLAVICVVK	0.0
8:3038672-3038672 G>T	0.0	4245	COLORECTAL	-	-	-	-	CSMD1	NM_033225,p.D1895E|ENST00000539096,p.D1895E|ENST00000542608,p.D1895E|uc003wqe.3,p.D1052E|uc011kwj.2,p.D1288E|ENST00000602723,p.D1896E|uc022aqr.1,p.D1895E|ENST00000602557,p.D1896E|ENST00000537824,p.D1895E|ENST00000400186,p.D1896E|ENST00000520002,p.D1896E	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon37	c.C5685A	p.D1895E	STSNQLYLHFQSDISVAAAGFHLEY	STSNQLYLHFQSEISVAAAGFHLEY	3.0	1.0	-	-	4245_8:3038672-3038672 G>T_STSNQLYLHFQSEISVAAAGFHLEY	0.0
5:147019323-147019323 T>C	0.0	4316	COLORECTAL	-	-	-	-	JAKMIP2	NM_001282282,p.S426G|NM_014790,p.S468G|uc011dbx.2,p.S426G|ENST00000507386,p.S468G|ENST00000333010,p.S426G|uc003loq.2,p.S468G|NM_001270941,p.S468G|uc010jgo.2,p.S468G|ENST00000265272,p.S468G|NM_001270934,p.S468G|uc003lor.2,p.S468G	retained_intron, protein_coding	uc011dbx.2	nonsynonymous SNV	exon9	c.A1276G	p.S426G	RTPATPDDDLDESLAAEESELRFRQ	RTPATPDDDLDEGLAAEESELRFRQ	3.0	3.0	-	-	4316_5:147019323-147019323 T>C_RTPATPDDDLDEGLAAEESELRFRQ	0.0
19:1979400-1979400 C>T	1.0	3879	MELANOMA	-	-	-	-	CSNK1G2	uc002lul.4,p.P284L|NM_001319,p.P284L|ENST00000255641,p.P284L|uc010dsu.3,p.P236L	retained_intron, protein_coding, processed_transcript	uc010dsu.3	nonsynonymous SNV	exon8	c.C707T	p.P236L	RATPIEVLCENFPEEMATYLRYVRR	RATPIEVLCENFLEEMATYLRYVRR	8.0	8.0	-	-	3879_19:1979400-1979400 C>T_RATPIEVLCENFLEEMATYLRYVRR	0.0
2:242738553-242738553 T>G	1.0	4317	COLORECTAL	-	-	-	-	GAL3ST2	ENST00000192314,p.L35V|NM_022134,p.L35V|uc002wcj.1,p.L35V	protein_coding	uc002wcj.1	nonsynonymous SNV	exon2	c.T103G	p.L35V	TLLLLAGFLHSDLELDTPLFGGQAE	TLLLLAGFLHSDVELDTPLFGGQAE	9.0	4.0	-	-	4317_2:242738553-242738553 T>G_TLLLLAGFLHSDVELDTPLFGGQAE	0.0
5:42719077-42719077 G>T	0.0	4129	NSCLC	-	-	-	-	GHR	NM_001242405,p.V490L|ENST00000537449,p.V303L|uc021xxz.1,p.V490L|ENST00000357703,p.V468L|NM_001242404,p.V490L|NM_001242403,p.V490L|uc021xxy.1,p.V490L|uc021xxv.1,p.V497L|NM_001242401,p.V490L|uc011cpq.2,p.V303L|uc021xyd.1,p.V468L|NM_001242402,p.V490L|uc021xxw.1,p.V490L|NM_000163,p.V490L|NM_001242406,p.V490L|uc003jmt.3,p.V490L|NM_001242460,p.V468L|uc003jmv.2,p.V490L|uc021xxx.1,p.V490L|NM_001242399,p.V497L|ENST00000230882,p.V490L|NM_001242400,p.V490L|uc021xya.1,p.V490L|uc003jmu.3,p.V490L	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xyd.1	nonsynonymous SNV	exon8	c.G1402T	p.V468L	PSSLSNIDFYAQVSDITPAGSVVLS	PSSLSNIDFYAQLSDITPAGSVVLS	3.0	7.0	-	-	4129_5:42719077-42719077 G>T_PSSLSNIDFYAQLSDITPAGSVVLS	0.0
7:98490149-98490149 G>A	0.0	2591	MELANOMA	-	-	-	1	TRRAP	NM_003496,p.E122K|uc003upp.3,p.E122K|ENST00000359863,p.E122K|ENST00000446306,p.E122K|NM_001244580,p.E122K|ENST00000355540,p.E122K|uc011kis.2,p.E122K	retained_intron, protein_coding	uc011kis.2	nonsynonymous SNV	exon5	c.G364A	p.E122K	TKNVLSVMFRFLETENEENVLICLR	TKNVLSVMFRFLKTENEENVLICLR	5.0	2.0	-	-	2591_7:98490149-98490149 G>A_TKNVLSVMFRFLKTENEENVLICLR	0.0
8:95416464-95416464 G>A	1.0	3678	MELANOMA	-	-	-	-	RAD54B	ENST00000336148,p.S262F|NM_001205263,p.S78F|uc003ygk.3,p.S262F|NM_012415,p.S262F|uc010may.2,p.S78F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010may.2	nonsynonymous SNV	exon4	c.C233T	p.S78F	NCKPRHDPYTPNSLVMPRPDKNHQW	NCKPRHDPYTPNFLVMPRPDKNHQW	6.0	5.0	-	-	3678_8:95416464-95416464 G>A_NCKPRHDPYTPNFLVMPRPDKNHQW	0.0
17:73539552-73539552 G>C	1.0	4252	COLORECTAL	-	-	-	-	LLGL2	ENST00000392550,p.R15S|ENST00000577200,p.R15S|ENST00000579392,p.R15S|ENST00000578363,p.R15S|ENST00000375227,p.R15S|ENST00000578536,p.R15S|NM_004524,p.R15S|uc010dgf.1,p.R15S|uc010dgg.2,p.R15S|uc002jog.1,p.R15S|NM_001031803,p.R15S|ENST00000580925,p.R15S|ENST00000580578,p.R15S|uc002joh.3,p.R15S|NM_001015002,p.R15S|ENST00000167462,p.R15S|ENST00000581713,p.R15S|uc002joi.3,p.R15S	retained_intron, protein_coding, nonsense_mediated_decay	uc010dgg.2	nonsynonymous SNV	exon2	c.G45C	p.R15S	RFLRPGHDPVRERLKRDLFQFNKTV	RFLRPGHDPVRESLKRDLFQFNKTV	10.0	5.0	-	-	4252_17:73539552-73539552 G>C_RFLRPGHDPVRESLKRDLFQFNKTV	0.0
9:113704334-113704334 C>T	1.0	3713	MELANOMA	-	-	-	-	LPAR1	ENST00000538760,p.G55R|uc004bfc.3,p.G54R|NM_001401,p.G54R|ENST00000358883,p.G54R|uc004bfb.3,p.G54R|ENST00000374431,p.G54R|ENST00000374430,p.G54R|NM_057159,p.G54R|uc011lwn.2,p.G36R|uc004bfa.3,p.G54R|ENST00000441240,p.G54R|uc011lwm.2,p.G55R|uc011lwo.2,p.G55R|uc010mub.3,p.G54R|ENST00000541779,p.G55R	protein_coding	uc011lwo.2	nonsynonymous SNV	exon2	c.G163A	p.G55R	ATEWNTVSKLVMGLGITVCIFIMLA	ATEWNTVSKLVMRLGITVCIFIMLA	3.0	4.0	-	-	3713_9:113704334-113704334 C>T_ATEWNTVSKLVMRLGITVCIFIMLA	0.0
12:51237706-51237706 C>T	0.0	4346	COLORECTAL	-	-	-	-	TMPRSS12	uc001rwx.4,p.P90L|uc001rwy.3,p.P90L|NM_182559,p.P90L|ENST00000551456,p.P90L|ENST00000398458,p.P90L	protein_coding	uc001rwy.3	nonsynonymous SNV	exon2	c.C269T	p.P90L	IIGGTEAQAGAWPWVVSLQIKYGRV	IIGGTEAQAGAWLWVVSLQIKYGRV	1.0	4.0	-	-	4346_12:51237706-51237706 C>T_IIGGTEAQAGAWLWVVSLQIKYGRV	0.0
X:99919837-99919837 T>C	0.0	4259	COLORECTAL	-	-	-	-	SRPX2	ENST00000373004,p.L141P|NM_014467,p.L141P|uc004egb.3,p.L141P	protein_coding, processed_transcript	uc004egb.3	nonsynonymous SNV	exon5	c.T422C	p.L141P	TSGTYTCTNGVLLDSRCDYSCSSGY	TSGTYTCTNGVLPDSRCDYSCSSGY	7.0	3.0	-	-	4259_X:99919837-99919837 T>C_TSGTYTCTNGVLPDSRCDYSCSSGY	0.0
19:20728006-20728006 G>A	1.0	4000	MELANOMA	-	-	-	-	ZNF737	NM_001159293,p.H335Y|ENST00000427401,p.H335Y|uc002npa.3,p.H335Y	protein_coding, nonsense_mediated_decay	uc002npa.3	nonsynonymous SNV	exon4	c.C1003T	p.H335Y	KHPSVLTTHKRIHTGEKPYKCEECG	KHPSVLTTHKRIYTGEKPYKCEECG	8.0	2.0	-	-	4000_19:20728006-20728006 G>A_KHPSVLTTHKRIYTGEKPYKCEECG	0.0
1:157514764-157514764 T>A	0.0	4081	COLORECTAL	-	-	-	-	FCRL5	uc009wsm.3,p.D139V|ENST00000361835,p.D139V|ENST00000356953,p.D139V|NM_031281,p.D139V|uc001fqu.3,p.D139V|ENST00000368189,p.D139V|uc010phv.1,p.D139V|ENST00000368191,p.D54V|uc010phw.1,p.D54V|NM_001195388,p.D139V|ENST00000368190,p.D139V|uc001fqv.1,p.D139V	protein_coding, processed_transcript	uc010phw.1	nonsynonymous SNV	exon3	c.A161T	p.D54V	AEVTLNNTIYKNDNVLAFLNKRTDF	AEVTLNNTIYKNVNVLAFLNKRTDF	5.0	2.0	-	-	4081_1:157514764-157514764 T>A_AEVTLNNTIYKNVNVLAFLNKRTDF	0.0
7:136938288-136938288 C>T	1.0	3795	MELANOMA	-	-	-	-	PTN	ENST00000348225,p.R71Q|uc003vtq.2,p.R71Q|NM_002825,p.R71Q|ENST00000393083,p.R71Q	protein_coding	uc003vtq.2	nonsynonymous SNV	exon3	c.G212A	p.R71Q	SGDCGLGTREGTRTGAECKQTMKTQ	SGDCGLGTREGTQTGAECKQTMKTQ	10.0	6.0	-	-	3795_7:136938288-136938288 C>T_SGDCGLGTREGTQTGAECKQTMKTQ	0.0
19:17756522-17756522 G>A	0.0	4160	COLORECTAL	-	-	-	-	UNC13A	uc031rjw.1,p.R773W|ENST00000252773,p.R773W|ENST00000519716,p.R773W|ENST00000550896,p.R771W|NM_001080421,p.R773W|ENST00000551649,p.R773W|ENST00000428389,p.R861W|ENST00000552293,p.R773W	retained_intron, protein_coding	uc031rjw.1	nonsynonymous SNV	exon19	c.C2317T	p.R773W	SDDFLGQTIIEVRTLSGEMDVWYNL	SDDFLGQTIIEVWTLSGEMDVWYNL	2.0	7.0	-	-	4160_19:17756522-17756522 G>A_SDDFLGQTIIEVWTLSGEMDVWYNL	0.0
9:97207274-97207274 T>G	1.0	4345	COLORECTAL	-	-	-	-	HIATL1	uc011luh.2,p.V115G|NM_032558,p.V180G|ENST00000375344,p.V180G|uc004aur.3,p.V180G|ENST00000428393,p.V115G	protein_coding	uc011luh.2	nonsynonymous SNV	exon5	c.T344G	p.V115G	YGWVSATFAASLVSSPAIGAYLSAS	YGWVSATFAASLGSSPAIGAYLSAS	8.0	5.0	-	-	4345_9:97207274-97207274 T>G_YGWVSATFAASLGSSPAIGAYLSAS	0.0
15:42174560-42174560 T>A	0.0	4037	NSCLC	-	-	-	-	SPTBN5	NM_016642,p.E718D|uc001zos.4,p.E718D|ENST00000320955,p.E718D	retained_intron, protein_coding	uc001zos.4	nonsynonymous SNV	exon11	c.A2154T	p.E718D	SARRPPTQPDPGERAEAVQGGWQLL	SARRPPTQPDPGDRAEAVQGGWQLL	3.0	10.0	-	-	4037_15:42174560-42174560 T>A_SARRPPTQPDPGDRAEAVQGGWQLL	0.0
1:201179380-201179380 T>G	0.0	4326	BREAST	-	-	-	-	IGFN1	NM_001164586,p.W1787G|ENST00000335211,p.W1787G|uc001gwc.3,p.W1787G	retained_intron, protein_coding, nonsense_mediated_decay	uc001gwc.3	nonsynonymous SNV	exon12	c.T5359G	p.W1787G	GSMDEAGYRKDLWAPEGIGSGSKAG	GSMDEAGYRKDLGAPEGIGSGSKAG	2.0	5.0	-	-	4326_1:201179380-201179380 T>G_GSMDEAGYRKDLGAPEGIGSGSKAG	0.0
14:105411707-105411707 G>A	1.0	3879	MELANOMA	-	-	-	-	AHNAK2	NM_138420,p.P3361S|ENST00000333244,p.P3361S|uc001ypx.2,p.P3261S|uc010axc.1,p.P3361S	retained_intron, protein_coding	uc010axc.1	nonsynonymous SNV	exon7	c.C10081T	p.P3361S	GDLKTTDLSIQLPSVDLEVQAGQVD	GDLKTTDLSIQLSSVDLEVQAGQVD	4.0	5.0	-	-	3879_14:105411707-105411707 G>A_GDLKTTDLSIQLSSVDLEVQAGQVD	0.0
9:32477066-32477066 T>C	1.0	4196	COLORECTAL	-	-	-	-	DDX58	uc003zra.3,p.D613G|uc010mjk.1,p.D568G|NM_014314,p.D613G|ENST00000379883,p.D613G|ENST00000379882,p.D568G|ENST00000545044,p.D410G|ENST00000379868,p.D410G|uc011lnr.1,p.D410G|uc010mji.3,p.D542G|ENST00000542096,p.D542G	protein_coding	uc011lnr.1	nonsynonymous SNV	exon12	c.A1229G	p.D410G	SRDPSNENPKLEDLCFILQEEYHLN	SRDPSNENPKLEGLCFILQEEYHLN	8.0	4.0	-	-	4196_9:32477066-32477066 T>C_SRDPSNENPKLEGLCFILQEEYHLN	0.0
3:65439012-65439012 A>C	1.0	4316	COLORECTAL	-	-	-	-	MAGI1	uc003dmn.3,p.H321Q|NM_004742,p.H321Q|ENST00000472257,p.H107Q|NM_001033057,p.H321Q|ENST00000402939,p.H321Q|uc003dmo.3,p.H321Q|uc003dmr.3,p.H322Q|ENST00000463103,p.H196Q|ENST00000497477,p.H321Q|NM_015520,p.H321Q|uc003dmm.3,p.H321Q|ENST00000479287,p.H83Q|ENST00000330909,p.H321Q|ENST00000483466,p.H321Q|uc021xac.1,p.H322Q|uc003dmp.3,p.H321Q|uc010hny.2,p.H206Q	retained_intron, protein_coding, processed_transcript	uc021xac.1	nonsynonymous SNV	exon6	c.T966G	p.H322Q	AYTENGEVYFIDHNTKTTSWLDPRC	AYTENGEVYFIDQNTKTTSWLDPRC	10.0	7.0	-	-	4316_3:65439012-65439012 A>C_AYTENGEVYFIDQNTKTTSWLDPRC	0.0
1:155172908-155172908 G>A	1.0	3713	MELANOMA	-	-	-	-	THBS3	ENST00000428962,p.P112S	protein_coding, processed_transcript	ENST00000428962	nonsynonymous SNV	exon4	c.C334T	p.P112S	LHSILGEGNVPDPKHHYGVSGFHEQ	LHSILGEGNVPDSKHHYGVSGFHEQ	7.0	5.0	-	-	3713_1:155172908-155172908 G>A_LHSILGEGNVPDSKHHYGVSGFHEQ	0.0
21:36080243-36080243 A>G	0.0	3903	MELANOMA	-	-	-	-	CLIC6	uc002yuf.1,p.K496E|ENST00000349499,p.K496E|ENST00000360731,p.K514E|uc010gmt.1,p.K514E|NM_053277,p.K496E	protein_coding	uc010gmt.1	nonsynonymous SNV	exon4	c.A1540G	p.K514E	VIFNVTTVDLKRKPADLQNLAPGTN	VIFNVTTVDLKREPADLQNLAPGTN	1.0	8.0	-	-	3903_21:36080243-36080243 A>G_VIFNVTTVDLKREPADLQNLAPGTN	0.0
7:80292314-80292314 C>A	1.0	4252	COLORECTAL	-	-	-	-	CD36	ENST00000441034,p.P84T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000441034	nonsynonymous SNV	exon3	c.C250A	p.P84T	NPQEVMMNSSCIPYLSKSICSNDPQ	NPQEVMMNSSCITYLSKSICSNDPQ	7.0	9.0	-	-	4252_7:80292314-80292314 C>A_NPQEVMMNSSCITYLSKSICSNDPQ	0.0
7:82997037-82997037 T>G	0.0	3919	MELANOMA	-	-	-	-	SEMA3E	uc003uhy.2,p.K731N|uc022agy.1,p.K671N|ENST00000427262,p.K671N|NM_012431,p.K731N|ENST00000307792,p.K731N|NM_001178129,p.K671N	protein_coding, nonsense_mediated_decay	uc022agy.1	nonsynonymous SNV	exon17	c.A2013C	p.K671N	YSNFQRVEEYCEKVWCTDRKRKKLK	YSNFQRVEEYCENVWCTDRKRKKLK	3.0	1.0	-	-	3919_7:82997037-82997037 T>G_YSNFQRVEEYCENVWCTDRKRKKLK	0.0
X:73960365-73960365 C>T	0.0	3903	MELANOMA	-	-	-	-	KIAA2022	uc004eby.3,p.E1343K|ENST00000373468,p.E1343K|ENST00000055682,p.E1343K|NM_001008537,p.E1343K	protein_coding	uc004eby.3	nonsynonymous SNV	exon3	c.G4027A	p.E1343K	QRFMMASIEPLWEPMEHHGDPNIFY	QRFMMASIEPLWKPMEHHGDPNIFY	1.0	10.0	-	-	3903_X:73960365-73960365 C>T_QRFMMASIEPLWKPMEHHGDPNIFY	0.0
1:77094328-77094328 C>T	1.0	3784	MELANOMA	-	-	-	-	ST6GALNAC3	uc010orh.1,p.P151L	protein_coding, processed_transcript	uc010orh.1	nonsynonymous SNV	exon3	c.C452T	p.P151L	TGKDRTEGYRKVPYHYYEQGRDECD	TGKDRTEGYRKVLYHYYEQGRDECD	5.0	2.0	-	-	3784_1:77094328-77094328 C>T_TGKDRTEGYRKVLYHYYEQGRDECD	0.0
8:11565948-11565948 C>T	0.0	4266	COLORECTAL	-	-	-	-	GATA4	ENST00000528027,p.R43W|uc003wuc.2,p.R43W|ENST00000532059,p.R43W|uc011kxb.1,p.R43W|ENST00000335135,p.R43W|NM_002052,p.R43W|uc011kxc.1,p.R43W|uc010lrz.1,p.R43W	retained_intron, protein_coding, processed_transcript	uc011kxc.1	nonsynonymous SNV	exon1	c.C127T	p.R43W	GAASSPVYVPTPRVPSSVLGLSYLQ	GAASSPVYVPTPWVPSSVLGLSYLQ	4.0	3.0	-	-	4266_8:11565948-11565948 C>T_GAASSPVYVPTPWVPSSVLGLSYLQ	0.0
7:12664735-12664735 A>T	0.0	4069	PANCREATIC	-	-	-	-	SCIN	ENST00000445618,p.H40L|ENST00000297029,p.H287L|NM_033128,p.H40L|ENST00000341757,p.H287L|ENST00000519209,p.H40L|uc003ssn.4,p.H287L|NM_001112706,p.H287L|uc003sso.4,p.H40L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003sso.4	nonsynonymous SNV	exon4	c.A119T	p.H40L	AMLLSEECFILDHGAAKQIFVWKGK	AMLLSEECFILDLGAAKQIFVWKGK	3.0	7.0	-	-	4069_7:12664735-12664735 A>T_AMLLSEECFILDLGAAKQIFVWKGK	0.0
16:72821334-72821334 C>T	1.0	3713	MELANOMA	-	-	-	1	ZFHX3	ENST00000268489,p.R3614K|uc002fck.3,p.R3614K|ENST00000397992,p.R2700K|uc002fcl.3,p.R2700K|NM_001164766,p.R2700K|NM_006885,p.R3614K	retained_intron, protein_coding	uc002fcl.3	nonsynonymous SNV	exon9	c.G8099A	p.R2700K	AAAPSSASPHASRKSWPQVVSRASA	AAAPSSASPHASKKSWPQVVSRASA	5.0	2.0	-	-	3713_16:72821334-72821334 C>T_AAAPSSASPHASKKSWPQVVSRASA	0.0
12:48367221-48367221 C>G	0.0	4078	GASTRIC	-	-	-	1	COL2A1	NM_033150,p.G1409A|uc001rqu.3,p.G1478A|ENST00000337299,p.G1409A|uc001rqt.3,p.G259A|uc001rqv.3,p.G1409A|NM_001844,p.G1478A|ENST00000380518,p.G1478A	retained_intron, protein_coding, processed_transcript	uc001rqv.3	nonsynonymous SNV	exon53	c.G4226C	p.G1409A	APMDIGGPEQEFGVDIGPVCFL	APMDIGGPEQEFAVDIGPVCFL	1.0	6.0	-	-	4078_12:48367221-48367221 C>G_APMDIGGPEQEFAVDIGPVCFL	0.0
2:175213643-175213643 T>C	1.0	4246	COLORECTAL	-	-	-	-	CIR1	uc002uim.3,p.K312R|ENST00000342016,p.K312R|uc002uin.3,p.K186R|NM_004882,p.K312R	retained_intron, protein_coding, nonsense_mediated_decay	uc002uin.3	nonsynonymous SNV	exon11	c.A557G	p.K186R	SGHNNSDSEEKDKSKKRKLHEELSS	SGHNNSDSEEKDRSKKRKLHEELSS	10.0	9.0	-	-	4246_2:175213643-175213643 T>C_SGHNNSDSEEKDRSKKRKLHEELSS	0.0
7:149129395-149129395 G>C	1.0	4244	COLORECTAL	-	-	-	-	ZNF777	NM_015694,p.I656M|uc003wfv.3,p.I656M|ENST00000247930,p.I656M	protein_coding	uc003wfv.3	nonsynonymous SNV	exon6	c.C1968G	p.I656M	SFSHKSSLTKHQITHTGERPYTCPE	SFSHKSSLTKHQMTHTGERPYTCPE	7.0	5.0	-	-	4244_7:149129395-149129395 G>C_SFSHKSSLTKHQMTHTGERPYTCPE	0.0
7:140373824-140373824 C>T	1.0	3713	MELANOMA	-	-	-	-	ADCK2	uc003vvz.3,p.L232F|ENST00000072869,p.L232F|uc003vvy.1,p.L232F|NM_052853,p.L232F|ENST00000476491,p.L232F	retained_intron, protein_coding	uc003vvz.3	nonsynonymous SNV	exon1	c.C694T	p.L232F	NTAFLETDSVQRLGRASCLPPFSHT	NTAFLETDSVQRFGRASCLPPFSHT	7.0	9.0	-	-	3713_7:140373824-140373824 C>T_NTAFLETDSVQRFGRASCLPPFSHT	0.0
5:140306979-140306979 C>A	0.0	4238	COLORECTAL	-	-	-	-	PCDHAC1	uc003lig.1,p.H168N|ENST00000253807,p.H168N|ENST00000409700,p.H168N|uc003lih.2,p.H168N|NM_031882,p.H168N|NM_018898,p.H168N	protein_coding	uc003lih.2	nonsynonymous SNV	exon1	c.C502A	p.H168N	NGILSYSLSPSQHFRLDMGSRVDGS	NGILSYSLSPSQNFRLDMGSRVDGS	1.0	2.0	-	-	4238_5:140306979-140306979 C>A_NGILSYSLSPSQNFRLDMGSRVDGS	0.0
3:9711119-9711119 G>T	1.0	4245	COLORECTAL	-	-	-	-	MTMR14	NM_001077525,p.G166V|ENST00000351233,p.G166V|uc003bsa.3,p.G166V|ENST00000296003,p.G166V|ENST00000353332,p.G166V|uc003brz.3,p.G166V|uc003bsb.3,p.G166V|NM_001077526,p.G166V|NM_022485,p.G166V	retained_intron, protein_coding, nonsense_mediated_decay	uc003bsb.3	nonsynonymous SNV	exon5	c.G497T	p.G166V	YGRSGYNYFFSGGADDAWADVEDVT	YGRSGYNYFFSGVADDAWADVEDVT	9.0	8.0	-	-	4245_3:9711119-9711119 G>T_YGRSGYNYFFSGVADDAWADVEDVT	0.0
6:114378489-114378489 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM1072326;OCCURENCE=2(endometrium),1(large_intestine)	-	HS3ST5	uc003pwh.4,p.R325C|uc003pwg.4,p.R325C|NM_153612,p.R325C|ENST00000312719,p.R325C|ENST00000411826,p.R325C	protein_coding, processed_transcript	uc003pwh.4	nonsynonymous SNV	exon5	c.C973T	p.R325C	HPEVDPSVITKLRKFFHPFNQKFYQ	HPEVDPSVITKLCKFFHPFNQKFYQ	2.0	5.0	-	-	4284_6:114378489-114378489 G>A_HPEVDPSVITKLCKFFHPFNQKFYQ	0.0
10:8007211-8007211 C>T	1.0	2591	MELANOMA	-	-	-	-	TAF3	NM_031923,p.L580F|ENST00000344293,p.L580F|uc010qbd.3,p.L580F	protein_coding	uc010qbd.3	nonsynonymous SNV	exon3	c.C1738T	p.L580F	TGRETKYPWKEFLKEEEADPYKFKI	TGRETKYPWKEFFKEEEADPYKFKI	5.0	7.0	-	-	2591_10:8007211-8007211 C>T_TGRETKYPWKEFFKEEEADPYKFKI	0.0
17:56423641-56423641 G>A	1.0	4189	MELANOMA	-	-	ID=COSM106392;OCCURENCE=1(skin)	-	SUPT4H1	ENST00000225504,p.A107V|ENST00000581540,p.A98V|uc002iwe.2,p.A107V|ENST00000580947,p.A107V|NM_003168,p.A107V|ENST00000577396,p.A66V	retained_intron, protein_coding, nonsense_mediated_decay	uc002iwe.2	nonsynonymous SNV	exon5	c.C320T	p.A107V	QGIVRELKSRGVAYKSRDTAIKT	QGIVRELKSRGVVYKSRDTAIKT	10.0	9.0	-	-	4189_17:56423641-56423641 G>A_QGIVRELKSRGVVYKSRDTAIKT	0.0
3:142268377-142268377 G>A	1.0	2369	MELANOMA	-	-	-	1	ATR	ENST00000383101,p.H975Y|NM_001184,p.H1039Y|uc003eux.4,p.H1039Y|ENST00000350721,p.H1039Y	retained_intron, protein_coding, nonsense_mediated_decay	uc003eux.4	nonsynonymous SNV	exon15	c.C3115T	p.H1039Y	EILINNFKYIFSHLVCSCSKDELER	EILINNFKYIFSYLVCSCSKDELER	7.0	4.0	-	-	2369_3:142268377-142268377 G>A_EILINNFKYIFSYLVCSCSKDELER	0.0
3:108110706-108110706 A>T	1.0	4326	BREAST	-	-	-	-	MYH15	NM_014981,p.N1797K|ENST00000273353,p.N1797K|uc003dxa.1,p.N1797K	retained_intron, protein_coding, processed_transcript	uc003dxa.1	nonsynonymous SNV	exon38	c.T5391A	p.N1797K	QDTIAHLERTRENMEQTITDLQKRL	QDTIAHLERTREKMEQTITDLQKRL	4.0	10.0	-	-	4326_3:108110706-108110706 A>T_QDTIAHLERTREKMEQTITDLQKRL	0.0
12:25398284-25398284 C>T	1.0	4298	COLORECTAL	-	-	ID=COSM521,COSM1135366;OCCURENCE=1(salivary_gland),171(endometrium),265(ovary),20(soft_tissue),19(urinary_tract),1(kidney),2323(pancreas),15(liver),3(eye),22(prostate),321(biliary_tract),6237(large_intestine),18(breast),24(skin),58(small_intestine),25(upper_aerodigestive_tract),10(oesophagus),4(central_nervous_system),93(stomach),2(testis),19(cervix),114(haematopoietic_and_lymphoid_tissue),15(gastrointestinal_tract_(site_indeterminate)),37(thyroid),737(lung),25(peritoneum)	1	KRAS	uc001rgq.1,p.G12D|ENST00000557334,p.G12D|NM_033360,p.G12D|ENST00000311936,p.G12D|ENST00000256078,p.G12D|NM_004985,p.G12D|uc001rgp.1,p.G12D|ENST00000556131,p.G12D	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35A	p.G12D	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGADGVGKSALTIQLI	7.0	9.0	-	-	4298_12:25398284-25398284 C>T_MTEYKLVVVGADGVGKSALTIQLI	0.0
4:25929970-25929970 C>G	1.0	4134	NSCLC	-	-	-	-	SMIM20	ENST00000506197,p.Q49E|uc003grw.4,p.Q49E|NM_001145432,p.Q49E	protein_coding, processed_transcript	uc003grw.4	nonsynonymous SNV	exon2	c.C145G	p.Q49E	KKEQAINRAGIVQEDVQPPGLKVWS	KKEQAINRAGIVEEDVQPPGLKVWS	8.0	2.0	-	-	4134_4:25929970-25929970 C>G_KKEQAINRAGIVEEDVQPPGLKVWS	0.0
19:36276359-36276359 C>A	1.0	4317	COLORECTAL	-	-	-	-	ARHGAP33	uc002obr.2,p.S639Y|uc002obv.1,p.S227Y|ENST00000378944,p.S503Y|uc002obt.2,p.S503Y|ENST00000007510,p.S639Y|NM_001172630,p.S503Y	retained_intron, protein_coding, processed_transcript	uc002obv.1	nonsynonymous SNV	exon6	c.C680A	p.S227Y	DTVTLRSAKSEESLSSQASGAGLQR	DTVTLRSAKSEEYLSSQASGAGLQR	9.0	8.0	-	-	4317_19:36276359-36276359 C>A_DTVTLRSAKSEEYLSSQASGAGLQR	0.0
1:65325883-65325883 G>C	1.0	4281	COLORECTAL	-	-	-	1	JAK1	NM_002227,p.F413L|uc009wam.1,p.F413L|ENST00000342505,p.F413L|uc001dbu.1,p.F413L	protein_coding, processed_transcript	uc009wam.1	nonsynonymous SNV	exon10	c.C1239G	p.F413L	EALSFVSLVDGYFRLTADAHHYLCT	EALSFVSLVDGYLRLTADAHHYLCT	9.0	1.0	-	-	4281_1:65325883-65325883 G>C_EALSFVSLVDGYLRLTADAHHYLCT	0.0
8:2808706-2808706 C>G	0.0	4259	COLORECTAL	-	-	-	-	CSMD1	uc022aqr.1,p.W3377C|ENST00000400186,p.W3201C|uc010lrg.3,p.W1269C|ENST00000602723,p.W3201C|NM_033225,p.W3377C|ENST00000537824,p.W3377C|ENST00000602557,p.W3378C|ENST00000520002,p.W3378C|uc011kwj.2,p.W2692C|ENST00000542608,p.W3200C	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon66	c.G10131C	p.W3377C	LGKRQPATLTVDWFNATSSKVNATF	LGKRQPATLTVDCFNATSSKVNATF	3.0	9.0	-	-	4259_8:2808706-2808706 C>G_LGKRQPATLTVDCFNATSSKVNATF	0.0
6:84865045-84865045 G>A	1.0	2556	MELANOMA	-	-	-	-	CEP162	uc003pki.4,p.T375I|NM_014895,p.T989I|uc003pkj.4,p.T913I|ENST00000257766,p.T913I|ENST00000403245,p.T989I|NM_001286206,p.T913I|uc010kbp.3,p.T989I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kbp.3	nonsynonymous SNV	exon22	c.C2966T	p.T989I	EGKDEDAKKSLRTMEQQFQKMKIQY	EGKDEDAKKSLRIMEQQFQKMKIQY	6.0	4.0	-	-	2556_6:84865045-84865045 G>A_EGKDEDAKKSLRIMEQQFQKMKIQY	0.0
12:25398284-25398284 C>T	1.0	4071	COLORECTAL	-	-	ID=COSM521,COSM1135366;OCCURENCE=1(salivary_gland),171(endometrium),265(ovary),20(soft_tissue),19(urinary_tract),1(kidney),2323(pancreas),15(liver),3(eye),22(prostate),321(biliary_tract),6237(large_intestine),18(breast),24(skin),58(small_intestine),25(upper_aerodigestive_tract),10(oesophagus),4(central_nervous_system),93(stomach),2(testis),19(cervix),114(haematopoietic_and_lymphoid_tissue),15(gastrointestinal_tract_(site_indeterminate)),37(thyroid),737(lung),25(peritoneum)	1	KRAS	ENST00000256078,p.G12D|ENST00000556131,p.G12D|NM_033360,p.G12D|uc001rgp.1,p.G12D|ENST00000557334,p.G12D|uc001rgq.1,p.G12D|NM_004985,p.G12D|ENST00000311936,p.G12D	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35A	p.G12D	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGADGVGKSALTIQLI	9.0	10.0	-	-	4071_12:25398284-25398284 C>T_MTEYKLVVVGADGVGKSALTIQLI	0.0
12:51868862-51868862 T>A	0.0	4281	COLORECTAL	-	-	-	-	SLC4A8	ENST00000453097,p.S682T|ENST00000358657,p.S709T|uc001rym.4,p.S629T|NM_001258403,p.S629T|ENST00000514353,p.S629T|NM_001258401,p.S629T|uc001ryr.3,p.S682T|uc001ryn.4,p.S629T|NM_001039960,p.S682T|uc001ryv.4,p.S629T|uc001rys.2,p.S682T|uc010snk.2,p.S629T|uc010snj.2,p.S709T|ENST00000394856,p.S629T	retained_intron, protein_coding, processed_transcript	uc010snk.2	nonsynonymous SNV	exon16	c.T1885A	p.S629T	SECQEMHGEFMGSACGHHGPYTPDV	SECQEMHGEFMGTACGHHGPYTPDV	4.0	5.0	-	-	4281_12:51868862-51868862 T>A_SECQEMHGEFMGTACGHHGPYTPDV	0.0
4:134084155-134084155 A>C	0.0	4213	COLORECTAL	-	-	-	-	PCDH10	NM_032961,p.T941P|ENST00000264360,p.T941P|uc003iha.3,p.T941P	retained_intron, protein_coding	uc003iha.3	nonsynonymous SNV	exon4	c.A2821C	p.T941P	AQSAGMDLFSNCTEECKALGHSDRC	AQSAGMDLFSNCPEECKALGHSDRC	5.0	4.0	-	-	4213_4:134084155-134084155 A>C_AQSAGMDLFSNCPEECKALGHSDRC	0.0
2:210809796-210809796 A>T	0.0	4081	COLORECTAL	-	-	-	-	UNC80	NM_032504,p.S2292C|ENST00000439458,p.S2292C|ENST00000272845,p.S2287C|NM_182587,p.S2287C|uc021vvx.1,p.S2287C|uc010zjc.1,p.S2292C|uc002vdk.2,p.S1453C	retained_intron, protein_coding, processed_transcript	uc021vvx.1	nonsynonymous SNV	exon45	c.A6859T	p.S2287C	LLEFPDAANNGPSKGVSAQCLFDLL	LLEFPDAANNGPCKGVSAQCLFDLL	1.0	3.0	-	-	4081_2:210809796-210809796 A>T_LLEFPDAANNGPCKGVSAQCLFDLL	0.0
9:111617170-111617170 C>T	0.0	4316	COLORECTAL	-	-	-	-	ACTL7B	NM_006686,p.M347I|ENST00000374667,p.M347I|uc004bdi.3,p.M347I	protein_coding	uc004bdi.3	nonsynonymous SNV	exon1	c.G1041A	p.M347I	MAANVLLCGGCTMLDGFPERFQREL	MAANVLLCGGCTILDGFPERFQREL	1.0	3.0	-	-	4316_9:111617170-111617170 C>T_MAANVLLCGGCTILDGFPERFQREL	0.0
7:31855733-31855733 G>A	0.0	4301	MELANOMA	-	-	ID=COSM1450409,COSM1450408,COSM1450407;OCCURENCE=1(large_intestine)	-	PDE1C	NM_001191058,p.R600C|uc003tco.2,p.R600C|ENST00000321453,p.R540C|uc003tcs.3,p.R540C|uc003tcm.2,p.R540C|ENST00000396193,p.R600C|ENST00000396191,p.R540C|NM_001191059,p.R540C|NM_005020,p.R540C|NM_001191057,p.R540C|ENST00000396182,p.R540C|NM_001191056,p.R540C|uc003tcn.1,p.R540C|ENST00000396184,p.R540C|uc003tcr.3,p.R540C	retained_intron, protein_coding, processed_transcript	uc003tcs.3	nonsynonymous SNV	exon16	c.C1618T	p.R540C	EEKAKKEAEEKARLAAEEQQKEMEA	EEKAKKEAEEKACLAAEEQQKEMEA	5.0	4.0	-	-	4301_7:31855733-31855733 G>A_EEKAKKEAEEKACLAAEEQQKEMEA	0.0
17:21207862-21207862 G>A	0.0	3713	MELANOMA	-	-	-	-	MAP2K3	ENST00000361818,p.M202I|uc021tsq.1,p.M202I|ENST00000316920,p.M202I|uc002gys.3,p.M231I|NM_145109,p.M231I|ENST00000342679,p.M231I|uc021tsr.1,p.M202I|uc002gyt.3,p.M202I|NM_002756,p.M202I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tsr.1	nonsynonymous SNV	exon9	c.G606A	p.M202I	VAKTMDAGCKPYMAPERINPELNQK	VAKTMDAGCKPYIAPERINPELNQK	6.0	4.0	-	-	3713_17:21207862-21207862 G>A_VAKTMDAGCKPYIAPERINPELNQK	0.0
8:62578013-62578013 G>A	0.0	3466	MELANOMA	-	-	-	-	ASPH	uc011lem.2,p.P144S|ENST00000522603,p.P144S|uc011lel.2,p.P159S|ENST00000389204,p.P159S|NM_032467,p.P144S|NM_020164,p.P159S	retained_intron, protein_coding, processed_transcript	uc011lem.2	nonsynonymous SNV	exon5	c.C430T	p.P144S	KIADADLSRKESPKGKKDREKEKVD	KIADADLSRKESSKGKKDREKEKVD	10.0	8.0	-	-	3466_8:62578013-62578013 G>A_KIADADLSRKESSKGKKDREKEKVD	0.0
X:49070706-49070706 G>C	0.0	4046	OVARIAN	-	-	-	-	CACNA1F	NM_001256790,p.F1153L|ENST00000323022,p.F1207L|uc031tjm.1,p.F1153L|uc004dnb.3,p.F1218L|NM_001256789,p.F1207L|NM_005183,p.F1218L|ENST00000376251,p.F1153L|ENST00000376265,p.F1218L|uc010nip.3,p.F1207L	retained_intron, protein_coding, processed_transcript	uc031tjm.1	nonsynonymous SNV	exon30	c.C3459G	p.F1153L	ALAMQHYEQTAPFNYAMDILNMVFT	ALAMQHYEQTAPLNYAMDILNMVFT	3.0	5.0	-	-	4046_X:49070706-49070706 G>C_ALAMQHYEQTAPLNYAMDILNMVFT	0.0
2:32702595-32702595 T>A	1.0	4037	NSCLC	-	-	-	2	BIRC6	uc010ezu.3,p.F2338I|ENST00000421745,p.F2338I|NM_016252,p.F2338I	retained_intron, protein_coding, nonsense_mediated_decay	uc010ezu.3	nonsynonymous SNV	exon35	c.T7012A	p.F2338I	ERCISVVQKLVLFLLSMDFTCHADL	ERCISVVQKLVLILLSMDFTCHADL	8.0	10.0	-	-	4037_2:32702595-32702595 T>A_ERCISVVQKLVLILLSMDFTCHADL	0.0
10:7409670-7409670 G>A	0.0	4238	COLORECTAL	-	-	-	-	SFMBT2	ENST00000379711,p.A126V|uc010qay.2,p.A126V|ENST00000379713,p.A126V|uc009xio.2,p.A126V|ENST00000397167,p.A126V|NM_001029880,p.A126V|ENST00000361972,p.A126V|uc001ijn.2,p.A126V|uc001ijo.2,p.A126V|ENST00000397160,p.A126V|NM_001018039,p.A126V	protein_coding	uc010qay.2	nonsynonymous SNV	exon4	c.C377T	p.A126V	DRRADFWCDVVIADLHPVGWCTQNN	DRRADFWCDVVIVDLHPVGWCTQNN	2.0	9.0	-	-	4238_10:7409670-7409670 G>A_DRRADFWCDVVIVDLHPVGWCTQNN	0.0
2:1500456-1500456 C>T	0.0	4275	COLORECTAL	0.01	-	ID=COSM3694892,COSM3694893;OCCURENCE=1(pancreas),1(large_intestine)	-	TPO	uc002qwy.1,p.R109W|NM_175719,p.R712W|NM_175721,p.R769W|uc002qwu.3,p.R712W|ENST00000349624,p.R596W|uc010yip.2,p.R769W|ENST00000469607,p.R243W|NM_001206745,p.R712W|uc002qwx.3,p.R712W|ENST00000346956,p.R769W|uc010yio.2,p.R596W|ENST00000382201,p.R712W|NM_001206744,p.R769W|NM_175722,p.R596W|ENST00000422464,p.R698W|ENST00000382198,p.R596W|ENST00000345913,p.R769W|uc002qww.3,p.R769W|uc002qwr.3,p.R769W|ENST00000329066,p.R769W|NM_000547,p.R769W|ENST00000337415,p.R769W	protein_coding, processed_transcript	uc010yip.2	nonsynonymous SNV	exon12	c.C2305T	p.R769W	EESGRRVLVYSCRHGYELQGREQLT	EESGRRVLVYSCWHGYELQGREQLT	1.0	5.0	-	-	4275_2:1500456-1500456 C>T_EESGRRVLVYSCWHGYELQGREQLT	0.0
19:52447512-52447512 C>T	1.0	4000	MELANOMA	-	-	-	-	ZNF613	NM_001031721,p.H126Y|uc002pya.2,p.H90Y|uc002pxz.2,p.H126Y|ENST00000391794,p.H90Y|NM_024840,p.H90Y|ENST00000293471,p.H126Y	protein_coding, processed_transcript	uc002pya.2	nonsynonymous SNV	exon6	c.C268T	p.H90Y	HQRKSDFPLRQNHDTFDLHGKILKS	HQRKSDFPLRQNYDTFDLHGKILKS	6.0	3.0	-	-	4000_19:52447512-52447512 C>T_HQRKSDFPLRQNYDTFDLHGKILKS	0.0
22:29877075-29877075 G>A	0.0	4298	COLORECTAL	-	-	-	-	NEFH	NM_021076,p.R275H|uc003afo.3,p.R275H|ENST00000310624,p.R275H	protein_coding	uc003afo.3	nonsynonymous SNV	exon1	c.G824A	p.R275H	LKCDVTSALREIRAQLEGHAVQSTL	LKCDVTSALREIHAQLEGHAVQSTL	5.0	2.0	-	-	4298_22:29877075-29877075 G>A_LKCDVTSALREIHAQLEGHAVQSTL	0.0
7:72857104-72857104 C>G	1.0	3466	MELANOMA	-	-	-	-	BAZ1B	ENST00000404251,p.E1349Q|ENST00000339594,p.E1349Q|NM_032408,p.E1349Q|uc003tyc.3,p.E1349Q	retained_intron, protein_coding	uc003tyc.3	nonsynonymous SNV	exon18	c.G4045C	p.E1349Q	SSRRQSLELQKCEEILHKIVKYRFS	SSRRQSLELQKCQEILHKIVKYRFS	10.0	9.0	-	-	3466_7:72857104-72857104 C>G_SSRRQSLELQKCQEILHKIVKYRFS	0.0
17:79173610-79173610 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	CEP131	uc002jzo.1,p.G311E|NM_014984,p.G311E|ENST00000450824,p.G311E|uc010wum.1,p.G311E|ENST00000269392,p.G311E|uc002jzn.1,p.G311E|NM_001009811,p.G311E|uc002jzp.1,p.G311E|ENST00000374782,p.G311E|ENST00000575907,p.G311E	protein_coding, processed_transcript	uc010wum.1	nonsynonymous SNV	exon9	c.G932A	p.G311E	AKREEQRQRSGEGTLLDLHQQKEAA	AKREEQRQRSGEETLLDLHQQKEAA	8.0	3.0	-	-	4258_17:79173610-79173610 C>T_AKREEQRQRSGEETLLDLHQQKEAA	0.0
1:231298819-231298819 C>T	0.0	4278	COLORECTAL	-	-	-	-	TRIM67	ENST00000366653,p.A35V|ENST00000444294,p.A35V|ENST00000366652,p.A35V|uc009xfn.1,p.A35V|NM_001004342,p.A35V	protein_coding	uc009xfn.1	nonsynonymous SNV	exon1	c.C104T	p.A35V	SHNVCLPCARTIAVQTPDGEQHLPQ	SHNVCLPCARTIVVQTPDGEQHLPQ	1.0	6.0	-	-	4278_1:231298819-231298819 C>T_SHNVCLPCARTIVVQTPDGEQHLPQ	0.0
6:15487700-15487700 C>T	1.0	3713	MELANOMA	-	-	-	-	JARID2	ENST00000341776,p.S278F|ENST00000397311,p.S106F|NM_004973,p.S278F|uc011div.3,p.S106F|uc011diw.1,p.S240F|uc011diu.1,p.S142F|NM_001267040,p.S106F|ENST00000541660,p.S240F|uc003nbj.4,p.S278F	protein_coding, processed_transcript	uc011diw.1	nonsynonymous SNV	exon5	c.C719T	p.S240F	SANHPAAAPSTGSSAKGLAATHHHP	SANHPAAAPSTGFSAKGLAATHHHP	6.0	2.0	-	-	3713_6:15487700-15487700 C>T_SANHPAAAPSTGFSAKGLAATHHHP	0.0
X:141291595-141291595 G>C	0.0	4258	ENDOMETRIAL	-	-	-	-	MAGEC2	uc022cfj.1,p.S60C|NM_016249,p.S60C|uc004fbu.2,p.S60C|ENST00000247452,p.S60C	protein_coding	uc022cfj.1	nonsynonymous SNV	exon1	c.C179G	p.S60C	LVFSPSSFSTSSSLILGGPEEEEVP	LVFSPSSFSTSSCLILGGPEEEEVP	1.0	4.0	-	-	4258_X:141291595-141291595 G>C_LVFSPSSFSTSSCLILGGPEEEEVP	0.0
15:74914482-74914482 C>T	1.0	4259	COLORECTAL	-	-	-	-	CLK3	uc002ayk.4,p.R58C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ayk.4	nonsynonymous SNV	exon2	c.C172T	p.R58C	GRCMQRSQQSSKRSSRSVEDDKEGH	GRCMQRSQQSSKCSSRSVEDDKEGH	10.0	5.0	-	-	4259_15:74914482-74914482 C>T_GRCMQRSQQSSKCSSRSVEDDKEGH	0.0
19:37487722-37487722 C>T	0.0	3919	MELANOMA	-	-	-	-	ZNF568	ENST00000433993,p.R245C|ENST00000444991,p.R377C|uc010efj.2,p.R181C|uc010efi.2,p.R181C|NM_001204839,p.R313C|ENST00000455427,p.R313C|uc010xtn.2,p.R313C|uc010efg.3,p.R377C|NM_001204838,p.R377C	retained_intron, protein_coding	uc010xtn.2	nonsynonymous SNV	exon9	c.C937T	p.R313C	KPHKCKECGKAFRSSSQISQHQRMH	KPHKCKECGKAFCSSSQISQHQRMH	3.0	8.0	-	-	3919_19:37487722-37487722 C>T_KPHKCKECGKAFCSSSQISQHQRMH	0.0
8:18729235-18729235 G>A	1.0	3466	MELANOMA	-	-	-	-	PSD3	ENST00000523619,p.S315F|ENST00000327040,p.S380F|ENST00000440756,p.S380F|uc003wza.3,p.S380F|NM_015310,p.S380F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003wza.3	nonsynonymous SNV	exon3	c.C1139T	p.S380F	PSERPGTSSGTFSPVRLDESGEDEV	PSERPGTSSGTFFPVRLDESGEDEV	6.0	9.0	-	-	3466_8:18729235-18729235 G>A_PSERPGTSSGTFFPVRLDESGEDEV	0.0
X:132437278-132437278 G>A	1.0	3879	MELANOMA	-	-	-	-	GPC4	NM_001448,p.L462F|uc011mvg.1,p.L392F|ENST00000370828,p.L462F|ENST00000535467,p.L392F|uc004exc.1,p.L462F	protein_coding	uc011mvg.1	nonsynonymous SNV	exon8	c.C1174T	p.L392F	VQVDTSKPDILILRQIMALRVMTSK	VQVDTSKPDILIFRQIMALRVMTSK	5.0	10.0	-	-	3879_X:132437278-132437278 G>A_VQVDTSKPDILIFRQIMALRVMTSK	0.0
16:56926069-56926069 G>A	0.0	4235	COLORECTAL	-	-	-	-	SLC12A3	NM_000339,p.A815T|ENST00000438926,p.A815T|uc010ccn.3,p.A814T|NM_001126107,p.A814T|ENST00000566786,p.A814T|uc002ekd.4,p.A815T	retained_intron, protein_coding, processed_transcript	uc010ccn.3	nonsynonymous SNV	exon20	c.G2440A	p.A814T	ASARGARPSVSGALDPKALVKEEQA	ASARGARPSVSGTLDPKALVKEEQA	1.0	10.0	-	-	4235_16:56926069-56926069 G>A_ASARGARPSVSGTLDPKALVKEEQA	0.0
17:8092597-8092597 C>G	1.0	4134	NSCLC	-	-	-	-	C17orf59	NM_017622,p.E288Q|ENST00000389017,p.E288Q|uc010vut.2,p.E288Q	protein_coding	uc010vut.2	nonsynonymous SNV	exon1	c.G862C	p.E288Q	DRLLRGLGGAVQELTALSVGCIQTY	DRLLRGLGGAVQQLTALSVGCIQTY	7.0	10.0	-	-	4134_17:8092597-8092597 C>G_DRLLRGLGGAVQQLTALSVGCIQTY	0.0
7:33427607-33427607 C>T	1.0	4345	COLORECTAL	-	-	-	-	BBS9	ENST00000354265,p.R621W|uc003tdr.1,p.R180W|NM_198428,p.R656W|NM_001033605,p.R651W|uc003tdq.1,p.R616W|NM_014451,p.R616W|ENST00000242067,p.R656W|uc003tdp.1,p.R651W|NM_001033604,p.R621W|uc003tds.1,p.R79W|uc003tdn.1,p.R656W|ENST00000355070,p.R651W|ENST00000350941,p.R616W|ENST00000396127,p.R621W|uc003tdo.1,p.R621W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003tds.1	nonsynonymous SNV	exon6	c.C235T	p.R79W	EYFELIDHHFELRINGEKLEELLSE	EYFELIDHHFELWINGEKLEELLSE	8.0	9.0	-	-	4345_7:33427607-33427607 C>T_EYFELIDHHFELWINGEKLEELLSE	0.0
7:150325502-150325502 C>T	0.0	4158	COLORECTAL	-	-	-	-	GIMAP6	NM_024711,p.G62S|NM_001244072,p.G132S|ENST00000328902,p.G62S|uc003whn.3,p.G62S|uc022apv.1,p.G132S|uc031szs.1,p.G84S	protein_coding	uc031szs.1	nonsynonymous SNV	exon2	c.G250A	p.G84S	GSGKSATGNSILGRDVFESKLSTRP	GSGKSATGNSILSRDVFESKLSTRP	5.0	9.0	-	-	4158_7:150325502-150325502 C>T_GSGKSATGNSILSRDVFESKLSTRP	0.0
16:30762571-30762571 C>G	1.0	4320	COLORECTAL	-	-	-	-	PHKG2	uc002dzl.1,p.I80M	retained_intron, protein_coding, nonsense_mediated_decay	uc002dzl.1	nonsynonymous SNV	exon2	c.C240G	p.I80M	EEVREATRRETHILRQVAGHPHISE	EEVREATRRETHMLRQVAGHPHISE	9.0	8.0	-	-	4320_16:30762571-30762571 C>G_EEVREATRRETHMLRQVAGHPHISE	0.0
9:35548524-35548524 G>C	0.0	4186	BREAST	-	-	-	-	RUSC2	uc003zww.3,p.R669T|NM_014806,p.R669T|ENST00000455600,p.R669T|ENST00000361226,p.R669T|NM_001135999,p.R669T|uc003zwx.4,p.R669T	protein_coding, processed_transcript	uc003zwx.4	nonsynonymous SNV	exon2	c.G2006C	p.R669T	PANSHTQRDARARADGGGTESRPVL	PANSHTQRDARATADGGGTESRPVL	2.0	7.0	-	-	4186_9:35548524-35548524 G>C_PANSHTQRDARATADGGGTESRPVL	0.0
4:90169517-90169517 G>C	1.0	4126	NSCLC	-	-	-	-	GPRIN3	uc021xqb.1,p.P582R|ENST00000333209,p.P582R|uc003hsm.1,p.P582R|NM_198281,p.P582R	protein_coding	uc021xqb.1	nonsynonymous SNV	exon1	c.C1745G	p.P582R	ESGGTESAANPTPSPIRKNQESTLE	ESGGTESAANPTRSPIRKNQESTLE	5.0	1.0	-	-	4126_4:90169517-90169517 G>C_ESGGTESAANPTRSPIRKNQESTLE	0.0
5:45267221-45267221 T>C	1.0	4213	COLORECTAL	-	-	-	-	HCN1	uc003jok.3,p.T585A|NM_021072,p.T585A|ENST00000303230,p.T585A	protein_coding	uc003jok.3	nonsynonymous SNV	exon7	c.A1753G	p.T585A	LEEYPMMRRAFETVAIDRLDRIGKK	LEEYPMMRRAFEAVAIDRLDRIGKK	3.0	3.0	-	-	4213_5:45267221-45267221 T>C_LEEYPMMRRAFEAVAIDRLDRIGKK	0.0
7:8272343-8272347 CTTAT>-	1.0	4259	COLORECTAL	-	-	-	-	ICA1	ENST00000265577,p.D18fs|ENST00000446305,p.D18fs|ENST00000430867,p.D18fs|NM_001276478,p.D18fs|uc003srr.4,p.D18fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003srr.4	frameshift deletion	exon3	c.53_57del	p.D18fs	CYPWDLQDRYAQDKSVVNKMQQKYW	CYPWDLQDRYAQVSCK	10.0	4.0	-	-	4259_7:8272343-8272347 CTTAT>-_CYPWDLQDRYAQVSCK	0.0
X:151869812-151869812 G>A	1.0	3998	MELANOMA	-	-	-	-	MAGEA6	ENST00000412733,p.E168K|ENST00000329342,p.E168K|uc004ffr.1,p.E168K|uc004ffq.1,p.E168K|ENST00000457643,p.E168K|uc022chf.1,p.E168K|NM_005363,p.E168K|NM_175868,p.E168K	protein_coding	uc022chf.1	nonsynonymous SNV	exon1	c.G502A	p.E168K	DSLQLVFGIELMEVDPIGHVYIFAT	DSLQLVFGIELMKVDPIGHVYIFAT	9.0	10.0	CD8	-	3998_X:151869812-151869812 G>A_DSLQLVFGIELMKVDPIGHVYIFAT	1.0
12:56088642-56088642 C>T	1.0	3795	MELANOMA	-	-	-	-	ITGA7	ENST00000553804,p.D710N|ENST00000452168,p.D613N|ENST00000347027,p.D700N|NM_001144997,p.D613N|NM_001144996,p.D710N|ENST00000257880,p.D750N|uc001shh.3,p.D710N|uc001shg.3,p.D706N|ENST00000555728,p.D750N|ENST00000257879,p.D706N|ENST00000394230,p.D710N|ENST00000394229,p.D706N|uc009znx.3,p.D587N|uc010sps.2,p.D613N|NM_002206,p.D706N	retained_intron, protein_coding, nonsense_mediated_decay	uc010sps.2	nonsynonymous SNV	exon15	c.G1837A	p.D613N	LPSDPAQPQADGDDAHEAQLLVMLP	LPSDPAQPQADGNDAHEAQLLVMLP	8.0	9.0	-	-	3795_12:56088642-56088642 C>T_LPSDPAQPQADGNDAHEAQLLVMLP	0.0
2:232135720-232135720 C>T	1.0	3879	MELANOMA	-	-	-	-	ARMC9	ENST00000446447,p.S24F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000446447	nonsynonymous SNV	exon2	c.C71T	p.S24F	TAATRSVLQLLHSTSDVVRQYMARL	TAATRSVLQLLHFTSDVVRQYMARL	9.0	7.0	-	-	3879_2:232135720-232135720 C>T_TAATRSVLQLLHFTSDVVRQYMARL	0.0
12:26639254-26639254 C>T	1.0	3678	MELANOMA	-	-	-	-	ITPR2	uc001rhg.3,p.G1865E|NM_002223,p.G1865E|ENST00000381340,p.G1865E|uc009zjg.1,p.G16E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009zjg.1	nonsynonymous SNV	exon4	c.G47A	p.G16E	RDSTLHLKEGMKGQLTEASSATSKA	RDSTLHLKEGMKEQLTEASSATSKA	8.0	2.0	-	-	3678_12:26639254-26639254 C>T_RDSTLHLKEGMKEQLTEASSATSKA	0.0
3:153994625-153994625 A>G	1.0	2556	MELANOMA	-	-	-	-	DHX36	uc003ezz.4,p.S889P|ENST00000329463,p.S904P|uc010hvq.3,p.S904P|ENST00000308361,p.S889P|NM_020865,p.S918P|uc003ezy.4,p.S918P|NM_001114397,p.S904P|ENST00000496811,p.S918P|ENST00000544526,p.S904P	retained_intron, protein_coding, nonsense_mediated_decay	uc010hvq.3	nonsynonymous SNV	exon24	c.T2710C	p.S904P	SPYCLLFFGGDISIQKDNDQETIAV	SPYCLLFFGGDIPIQKDNDQETIAV	9.0	2.0	-	-	2556_3:153994625-153994625 A>G_SPYCLLFFGGDIPIQKDNDQETIAV	0.0
4:126411160-126411160 A>C	0.0	4186	BREAST	-	-	-	1	FAT4	NM_024582,p.K4395Q|uc003ifi.1,p.K1872Q|NM_001291303,p.K4397Q|ENST00000394329,p.K4395Q|ENST00000335110,p.K2636Q|uc003ifj.4,p.K4395Q|NM_001291285,p.K4396Q|uc011cgp.2,p.K2636Q	retained_intron, protein_coding	uc011cgp.2	nonsynonymous SNV	exon15	c.A7906C	p.K2636Q	SLASISKTDPSVKIGCRGPNICASN	SLASISKTDPSVQIGCRGPNICASN	1.0	7.0	-	-	4186_4:126411160-126411160 A>C_SLASISKTDPSVQIGCRGPNICASN	0.0
7:87908753-87908753 G>T	0.0	4110	BILE DUCT	-	-	-	-	STEAP4	uc003ujs.3,p.T447K|NM_024636,p.T447K|NM_001205316,p.T271K|uc010lek.3,p.T271K|NM_001205315,p.T447K|ENST00000380079,p.T447K|uc022agz.1,p.T447K|ENST00000301959,p.T271K	protein_coding	uc022agz.1	nonsynonymous SNV	exon6	c.C1340A	p.T447K	FVLIMPCVDNTLTRIRQGWERNSKH	FVLIMPCVDNTLKRIRQGWERNSKH	4.0	6.0	-	-	4110_7:87908753-87908753 G>T_FVLIMPCVDNTLKRIRQGWERNSKH	0.0
7:100304776-100304776 T>C	1.0	3998	MELANOMA	-	-	-	-	POP7	uc003uwh.4,p.V108A|NM_005837,p.V108A|ENST00000457480,p.V108A|uc022ais.1,p.V108A|ENST00000303151,p.V108A	protein_coding	uc022ais.1	nonsynonymous SNV	exon1	c.T323C	p.V108A	LQVAANTSTVELVDELEPETDTREP	LQVAANTSTVELADELEPETDTREP	7.0	6.0	-	-	3998_7:100304776-100304776 T>C_LQVAANTSTVELADELEPETDTREP	0.0
14:24587723-24587723 A>G	1.0	4281	COLORECTAL	-	-	-	-	DCAF11	ENST00000559115,p.Y235C|uc001wma.4,p.Y235C|uc001wlv.3,p.Y235C|ENST00000446197,p.Y235C|uc001wlw.3,p.Y235C|uc010tny.2,p.Y102C|uc001wmb.4,p.Y209C|NM_181357,p.Y209C|NM_001163484,p.Y235C|ENST00000396936,p.Y135C|NM_025230,p.Y235C|ENST00000396941,p.Y209C|uc001wly.3,p.Y191C|uc001wmc.3,p.Y135C|uc001wlz.3,p.Y135C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tny.2	nonsynonymous SNV	exon6	c.A305G	p.Y102C	DVAFTPDGNHFLYSSWSDYIHICNI	DVAFTPDGNHFLCSSWSDYIHICNI	9.0	10.0	-	-	4281_14:24587723-24587723 A>G_DVAFTPDGNHFLCSSWSDYIHICNI	0.0
12:133219844-133219844 G>A	1.0	4252	COLORECTAL	-	-	-	1	POLE	uc001ukr.1,p.S310L|NM_006231,p.S1506L|uc001uks.1,p.S1506L|ENST00000535270,p.S1479L|ENST00000320574,p.S1506L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001uks.1	nonsynonymous SNV	exon35	c.C4517T	p.S1506L	QAHKALFGIFIPSQRRASVFVLDTV	QAHKALFGIFIPLQRRASVFVLDTV	9.0	9.0	-	-	4252_12:133219844-133219844 G>A_QAHKALFGIFIPLQRRASVFVLDTV	0.0
9:94538025-94538025 T>C	0.0	4160	COLORECTAL	-	-	-	-	ROR2	ENST00000375708,p.K58R|uc004ark.3,p.K58R|uc004arj.2,p.K58R|NM_004560,p.K58R	retained_intron, protein_coding, processed_transcript	uc004ark.3	nonsynonymous SNV	exon2	c.A173G	p.K58R	PLDGQDGPIPTLKGYFLNFLEPVNN	PLDGQDGPIPTLRGYFLNFLEPVNN	5.0	4.0	-	-	4160_9:94538025-94538025 T>C_PLDGQDGPIPTLRGYFLNFLEPVNN	0.0
19:40964133-40964133 G>A	1.0	3903	MELANOMA	-	-	-	-	BLVRB	uc002onw.2,p.S88F|ENST00000595483,p.S88F|ENST00000597870,p.S88F|NM_000713,p.S88F|ENST00000263368,p.S88F	retained_intron, protein_coding, nonsense_mediated_decay	uc002onw.2	nonsynonymous SNV	exon3	c.C263T	p.S88F	GTRNDLSPTTVMSEGARNIVAAMKA	GTRNDLSPTTVMFEGARNIVAAMKA	10.0	5.0	-	-	3903_19:40964133-40964133 G>A_GTRNDLSPTTVMFEGARNIVAAMKA	0.0
16:83781802-83781802 C>T	0.0	3713	MELANOMA	-	-	-	-	CDH13	ENST00000428848,p.S504F|NM_001220489,p.S504F|ENST00000268613,p.S590F|uc002fgx.3,p.S543F|NM_001220488,p.S590F|uc010vnt.2,p.S289F|NM_001257,p.S543F|uc010vns.2,p.S590F|uc010vnu.2,p.S504F|NM_001220490,p.S289F|ENST00000566620,p.S543F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vnu.2	nonsynonymous SNV	exon10	c.C1511T	p.S504F	GTVDTTAVLDRESPFVDNSVYTALF	GTVDTTAVLDREFPFVDNSVYTALF	3.0	1.0	-	-	3713_16:83781802-83781802 C>T_GTVDTTAVLDREFPFVDNSVYTALF	0.0
19:50885412-50885412 C>T	0.0	4335	COLORECTAL	-	-	-	-	NR1H2	ENST00000598168,p.T376M|ENST00000599105,p.T362M|ENST00000253727,p.T406M|ENST00000593926,p.T406M|ENST00000411902,p.T309M|ENST00000542413,p.T137M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000599105	nonsynonymous SNV	exon9	c.C1085T	p.T362M	LQQPYVEALLSYTRIKRPQDQLRFP	LQQPYVEALLSYMRIKRPQDQLRFP	7.0	5.0	-	-	4335_19:50885412-50885412 C>T_LQQPYVEALLSYMRIKRPQDQLRFP	0.0
2:131674847-131674847 G>A	0.0	3903	MELANOMA	-	-	-	-	ARHGEF4	ENST00000409359,p.G780R|ENST00000438985,p.G104R|uc002trz.1,p.G570R|uc010fmw.1,p.G570R	retained_intron, protein_coding, processed_transcript	uc010fmw.1	nonsynonymous SNV	exon1	c.G1708A	p.G570R	RPSAQRMGLHYPGRGSAISMVSLGS	RPSAQRMGLHYPRRGSAISMVSLGS	4.0	1.0	-	-	3903_2:131674847-131674847 G>A_RPSAQRMGLHYPRRGSAISMVSLGS	0.0
12:57987901-57987901 C>T	1.0	3713	MELANOMA	-	-	-	-	PIP4K2C	ENST00000540759,p.H90Y|ENST00000550095,p.H90Y|ENST00000422156,p.H90Y|uc001sou.3,p.H90Y|NM_001146260,p.H90Y|NM_024779,p.H90Y|ENST00000354947,p.H90Y|uc001sot.3,p.H90Y|uc010srt.2,p.H90Y|NM_001146258,p.H90Y|ENST00000551772,p.H69Y	protein_coding, nonsense_mediated_decay	uc010srt.2	nonsynonymous SNV	exon2	c.C268T	p.H90Y	ASSKIKVNNHLFHRENLPSHFKFKE	ASSKIKVNNHLFYRENLPSHFKFKE	7.0	5.0	-	-	3713_12:57987901-57987901 C>T_ASSKIKVNNHLFYRENLPSHFKFKE	0.0
9:8528768-8528768 G>A	0.0	4301	MELANOMA	-	-	ID=COSM1686078,COSM1686081,COSM1686079,COSM1686082,COSM1686080;OCCURENCE=2(skin)	-	PTPRD	NM_130392,p.P122S|uc003zkt.1,p.P122S|ENST00000463477,p.P122S|uc003zkq.3,p.P122S|uc003zkp.3,p.P122S|uc003zks.3,p.P122S|uc022bdj.1,p.P122S|ENST00000540109,p.P122S|ENST00000360074,p.P122S|ENST00000358503,p.P122S|ENST00000397617,p.P122S|ENST00000397606,p.P122S|NM_001040712,p.P122S|ENST00000355233,p.P122S|ENST00000537002,p.P122S|NM_001171025,p.P122S|ENST00000486161,p.P122S|NM_002839,p.P122S|ENST00000397611,p.P122S|NM_130391,p.P122S|uc003zkk.3,p.P122S|ENST00000381196,p.P122S|NM_130393,p.P122S|ENST00000356435,p.P122S|uc003zkr.3,p.P122S	retained_intron, protein_coding, processed_transcript	uc022bdj.1	nonsynonymous SNV	exon4	c.C364T	p.P122S	STRLTVLREDQIPRGFPTIDMGPQL	STRLTVLREDQISRGFPTIDMGPQL	4.0	8.0	-	-	4301_9:8528768-8528768 G>A_STRLTVLREDQISRGFPTIDMGPQL	0.0
16:55725894-55725894 C>T	1.0	4281	COLORECTAL	-	-	ID=COSM3818107,COSM3818108;OCCURENCE=1(breast)	-	SLC6A2	uc002eig.3,p.T283M|NM_001043,p.T283M|ENST00000567238,p.T178M|uc002eii.3,p.T178M|NM_001172504,p.T283M|NM_001172501,p.T283M|ENST00000414754,p.T283M|ENST00000379906,p.T283M|ENST00000568943,p.T283M|ENST00000561820,p.T283M|ENST00000219833,p.T283M|uc002eif.3,p.T283M|uc021tio.1,p.T283M|NM_001172502,p.T178M	protein_coding	uc021tio.1	nonsynonymous SNV	exon5	c.C848T	p.T283M	YFVLFVLLVHGVTLPGASNGINAYL	YFVLFVLLVHGVMLPGASNGINAYL	2.0	7.0	-	-	4281_16:55725894-55725894 C>T_YFVLFVLLVHGVMLPGASNGINAYL	0.0
9:37746714-37746714 C>T	0.0	4095	COLORECTAL	-	-	-	-	FRMPD1	ENST00000377765,p.T1562M|ENST00000539465,p.T1562M|uc004aah.1,p.T1562M|NM_014907,p.T1562M|uc004aag.1,p.T1562M	protein_coding	uc004aah.1	nonsynonymous SNV	exon16	c.C4685T	p.T1562M	SVKLLARQCTALTAAVFCLTQKFRA	SVKLLARQCTALMAAVFCLTQKFRA	5.0	9.0	-	-	4095_9:37746714-37746714 C>T_SVKLLARQCTALMAAVFCLTQKFRA	0.0
18:9859260-9859260 G>A	0.0	3713	MELANOMA	-	-	-	-	RAB31	NM_006868,p.G176R|ENST00000578921,p.G176R|uc002kog.2,p.G176R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kog.2	nonsynonymous SNV	exon7	c.G526A	p.G176R	SRQIPPLDPHENGNNGTIKVEKPTM	SRQIPPLDPHENRNNGTIKVEKPTM	7.0	5.0	-	-	3713_18:9859260-9859260 G>A_SRQIPPLDPHENRNNGTIKVEKPTM	0.0
4:56762946-56762946 C>T	1.0	3713	MELANOMA	-	-	-	-	EXOC1	ENST00000346134,p.P673S|ENST00000349598,p.P658S|uc003hbe.1,p.P673S|NM_018261,p.P673S|uc003hbf.1,p.P673S|NM_178237,p.P658S|ENST00000381295,p.P673S|NM_001024924,p.P673S|uc003hbg.1,p.P658S	retained_intron, protein_coding	uc003hbg.1	nonsynonymous SNV	exon15	c.C1972T	p.P658S	VKISKKSKVGILPFVAEFEEFAGLA	VKISKKSKVGILSFVAEFEEFAGLA	6.0	8.0	-	-	3713_4:56762946-56762946 C>T_VKISKKSKVGILSFVAEFEEFAGLA	0.0
5:56531850-56531850 G>T	1.0	3879	MELANOMA	-	-	-	-	GPBP1	ENST00000264779,p.G164C|uc003jrk.4,p.G164C|uc003jrj.4,p.G164C|NM_001127235,p.G164C|ENST00000511209,p.G164C|NM_001127236,p.G164C|ENST00000538707,p.G164C|uc003jrh.4,p.G157C|NM_022913,p.G157C|ENST00000506184,p.G157C	retained_intron, protein_coding	uc003jrk.4	nonsynonymous SNV	exon5	c.G490T	p.G164C	EREPNHNKSLAAGVWEYPPNPKSRA	EREPNHNKSLAACVWEYPPNPKSRA	10.0	2.0	-	-	3879_5:56531850-56531850 G>T_EREPNHNKSLAACVWEYPPNPKSRA	0.0
14:24437989-24437989 C>G	0.0	4186	BREAST	-	-	-	-	DHRS4	NM_001282991,p.A129G|ENST00000308178,p.A111G|NM_001282989,p.A163G|ENST00000558581,p.A215G|uc001wla.3,p.A249G|uc010akz.3,p.A170G|NM_001282990,p.A170G|ENST00000397075,p.A163G|NM_021004,p.A249G|ENST00000397073,p.A152G|uc001wlb.3,p.A215G|NM_001282988,p.A215G|ENST00000559632,p.A170G|ENST00000313250,p.A249G|ENST00000397074,p.A129G|ENST00000421831,p.A197G	protein_coding	uc010akz.3	nonsynonymous SNV	exon6	c.C509G	p.A170G	LRIRRLGEPEDCAGIVSFLCSEDAS	LRIRRLGEPEDCGGIVSFLCSEDAS	9.0	5.0	-	-	4186_14:24437989-24437989 C>G_LRIRRLGEPEDCGGIVSFLCSEDAS	0.0
1:186329430-186329430 A>G	1.0	3466	MELANOMA	-	-	-	1	TPR	uc010pop.2,p.V465A|uc001grv.3,p.V389A|NM_003292,p.V389A|ENST00000367478,p.V389A	retained_intron, protein_coding, processed_transcript	uc010pop.2	nonsynonymous SNV	exon12	c.T1394C	p.V465A	AMSPTAAAVAKIVKPGMKLTELYNA	AMSPTAAAVAKIAKPGMKLTELYNA	9.0	5.0	-	-	3466_1:186329430-186329430 A>G_AMSPTAAAVAKIAKPGMKLTELYNA	0.0
19:36398655-36398655 G>A	0.0	4301	MELANOMA	-	-	-	-	TYROBP	uc002ocm.3,p.P24L|NM_003332,p.P24L|ENST00000589517,p.P24L|ENST00000585901,p.P24L|uc002ocn.3,p.P24L|ENST00000262629,p.P24L|NM_198125,p.P24L	retained_intron, protein_coding, nonsense_mediated_decay	uc002ocn.3	nonsynonymous SNV	exon2	c.C71T	p.P24L	LLPLLLAVSGLRPVQAQAQSDCSCS	LLPLLLAVSGLRLVQAQAQSDCSCS	10.0	2.0	-	-	4301_19:36398655-36398655 G>A_LLPLLLAVSGLRLVQAQAQSDCSCS	0.0
8:69005888-69005888 G>T	0.0	4078	GASTRIC	-	-	-	1	PREX2	ENST00000288368,p.D767Y|uc011lez.1,p.D702Y|NM_024870,p.D767Y|NM_025170,p.D767Y|uc003xxv.1,p.D767Y|uc003xxu.1,p.D767Y	protein_coding, processed_transcript	uc011lez.1	nonsynonymous SNV	exon19	c.G2104T	p.D702Y	QWVYNSIESAQEDLQKSHSKPPGDE	QWVYNSIESAQEYLQKSHSKPPGDE	4.0	8.0	-	-	4078_8:69005888-69005888 G>T_QWVYNSIESAQEYLQKSHSKPPGDE	0.0
11:117395552-117395552 G>A	1.0	4301	MELANOMA	-	-	-	-	DSCAML1	uc001pri.1,p.S166L|ENST00000321322,p.S362L|ENST00000527706,p.S92L|uc001prh.1,p.S362L|NM_020693,p.S362L	protein_coding	uc001pri.1	nonsynonymous SNV	exon5	c.C497T	p.S166L	GTYICEVTNTFGSAEATGILMVIDP	GTYICEVTNTFGLAEATGILMVIDP	4.0	5.0	-	-	4301_11:117395552-117395552 G>A_GTYICEVTNTFGLAEATGILMVIDP	0.0
6:38750810-38750810 G>A	0.0	3795	MELANOMA	0.0005	-	-	-	DNAH8	uc003ooe.2,p.G547S|NM_001206927,p.G764S|uc021yzh.1,p.G764S|ENST00000359357,p.G547S|ENST00000449981,p.G764S|ENST00000441566,p.G547S|ENST00000327475,p.G752S	protein_coding	uc021yzh.1	nonsynonymous SNV	exon17	c.G2290A	p.G764S	FFKNSDILSSPDGKAVIRQYNKISY	FFKNSDILSSPDSKAVIRQYNKISY	2.0	7.0	-	-	3795_6:38750810-38750810 G>A_FFKNSDILSSPDSKAVIRQYNKISY	0.0
7:8095112-8095112 G>A	1.0	3919	MELANOMA	-	-	-	-	GLCCI1	ENST00000414914,p.R107H|ENST00000223145,p.R249H|uc003srk.4,p.R249H|NM_138426,p.R249H|ENST00000430798,p.R137H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003srk.4	nonsynonymous SNV	exon4	c.G746A	p.R249H	LRQQLQRSKQSSRHSKEKDRQSPLH	LRQQLQRSKQSSHHSKEKDRQSPLH	6.0	7.0	-	-	3919_7:8095112-8095112 G>A_LRQQLQRSKQSSHHSKEKDRQSPLH	0.0
7:82764847-82764847 G>T	0.0	4245	COLORECTAL	-	-	-	-	PCLO	uc003uhx.2,p.S673R|NM_014510,p.S673R|uc003uhv.2,p.S673R|ENST00000423517,p.S673R|NM_033026,p.S673R|ENST00000333891,p.S673R	protein_coding, processed_transcript, nonsense_mediated_decay	uc003uhx.2	nonsynonymous SNV	exon3	c.C2019A	p.S673R	LKTAPVTTTSAVSKSSPQPQQTSPK	LKTAPVTTTSAVRKSSPQPQQTSPK	7.0	5.0	-	-	4245_7:82764847-82764847 G>T_LKTAPVTTTSAVRKSSPQPQQTSPK	0.0
3:178928067-178928067 C>A	1.0	4317	COLORECTAL	-	-	ID=COSM18601,COSM1670714;OCCURENCE=1(large_intestine)	1	PIK3CA	ENST00000263967,p.P449T|uc003fjk.3,p.P449T|NM_006218,p.P449T	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon8	c.C1345A	p.P449T	VSGKMALNLWPVPHGLEDLLNPIGV	VSGKMALNLWPVTHGLEDLLNPIGV	7.0	10.0	CD8	-	4317_3:178928067-178928067 C>A_VSGKMALNLWPVTHGLEDLLNPIGV	1.0
7:99445222-99445222 G>A	0.0	3998	MELANOMA	0.0005	-	-	-	CYP3A43	ENST00000433277,p.E93K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000433277	nonsynonymous SNV	exon3	c.G277A	p.E93K	LLSPAFTSVKFKEVRK	LLSPAFTSVKFKKVRK	2.0	8.0	-	-	3998_7:99445222-99445222 G>A_LLSPAFTSVKFKKVRK	0.0
4:134071984-134071984 G>A	0.0	4158	COLORECTAL	-	-	-	-	PCDH10	ENST00000264360,p.R230H|uc003iha.3,p.R230H|NM_020815,p.R230H|uc003igz.3,p.R230H|NM_032961,p.R230H	retained_intron, protein_coding	uc003iha.3	nonsynonymous SNV	exon1	c.G689A	p.R230H	GGGGAGLPPQQQRTGTALLTIRVLD	GGGGAGLPPQQQHTGTALLTIRVLD	5.0	6.0	-	-	4158_4:134071984-134071984 G>A_GGGGAGLPPQQQHTGTALLTIRVLD	0.0
20:32264633-32264633 C>T	0.0	4186	BREAST	-	-	-	-	E2F1	uc002wzu.4,p.E407K|NM_005225,p.E407K|ENST00000343380,p.E407K	protein_coding	uc002wzu.4	nonsynonymous SNV	exon7	c.G1219A	p.E407K	LPEEFISLSPPHEALDYHFGLEEGE	LPEEFISLSPPHKALDYHFGLEEGE	8.0	6.0	-	-	4186_20:32264633-32264633 C>T_LPEEFISLSPPHKALDYHFGLEEGE	0.0
2:101666939-101666939 T>G	0.0	4189	MELANOMA	-	-	-	-	TBC1D8	ENST00000409318,p.T266P|NM_001102426,p.T251P|uc010fiv.3,p.T251P|ENST00000376840,p.T251P|uc010yvw.2,p.T266P	retained_intron, protein_coding, processed_transcript	uc010yvw.2	nonsynonymous SNV	exon5	c.A796C	p.T266P	EVFKVMEQLADVTLRRLLDNEVFDL	EVFKVMEQLADVPLRRLLDNEVFDL	6.0	2.0	-	-	4189_2:101666939-101666939 T>G_EVFKVMEQLADVPLRRLLDNEVFDL	0.0
1:51767919-51767919 C>T	0.0	2556	MELANOMA	-	-	-	-	TTC39A	uc001cso.1,p.G366E|ENST00000262676,p.G366E	protein_coding, processed_transcript	uc001cso.1	nonsynonymous SNV	exon11	c.G1097A	p.G366E	CDILRDRIDWGRGGGQERTNQRAGA	CDILRDRIDWGREGGQERTNQRAGA	3.0	5.0	-	-	2556_1:51767919-51767919 C>T_CDILRDRIDWGREGGQERTNQRAGA	0.0
7:33035946-33035946 C>T	1.0	3713	MELANOMA	-	-	-	2	FKBP9	ENST00000242209,p.T404I|ENST00000538443,p.T266I|uc011kam.2,p.T172I|NM_001284341,p.T457I|ENST00000490776,p.T172I|NM_007270,p.T404I|ENST00000418354,p.T172I|ENST00000538336,p.T457I|uc011kal.2,p.T457I|uc003tdh.3,p.T404I|NM_001284343,p.T172I	retained_intron, protein_coding, processed_transcript	uc011kam.2	nonsynonymous SNV	exon4	c.C515T	p.T172I	LKYHYNASLLDGTLLDSTWNLGKTY	LKYHYNASLLDGILLDSTWNLGKTY	9.0	7.0	-	-	3713_7:33035946-33035946 C>T_LKYHYNASLLDGILLDSTWNLGKTY	0.0
14:97326950-97326950 C>T	1.0	3775	CERVICAL	-	-	-	-	VRK1	NM_003384,p.L316F|uc001yft.3,p.L316F|ENST00000216639,p.L316F	retained_intron, protein_coding, processed_transcript	uc001yft.3	nonsynonymous SNV	exon11	c.C946T	p.L316F	ETVKLLDYTEKPLYENLRDILLQGL	ETVKLLDYTEKPFYENLRDILLQGL	8.0	7.0	-	-	3775_14:97326950-97326950 C>T_ETVKLLDYTEKPFYENLRDILLQGL	0.0
22:42606183-42606183 T>G	0.0	4317	COLORECTAL	-	-	-	-	TCF20	ENST00000335626,p.K1710T|ENST00000359486,p.K1710T|uc003bck.1,p.K1710T|NM_005650,p.K1710T|NM_181492,p.K1710T|uc003bcj.1,p.K1710T	protein_coding	uc003bck.1	nonsynonymous SNV	exon1	c.A5129C	p.K1710T	SVMGHLVCCLCGKWASYRNMGDLFG	SVMGHLVCCLCGTWASYRNMGDLFG	9.0	3.0	-	-	4317_22:42606183-42606183 T>G_SVMGHLVCCLCGTWASYRNMGDLFG	0.0
14:23816828-23816828 C>T	1.0	4284	COLORECTAL	-	-	-	-	SLC22A17	ENST00000206544,p.V353I|uc001wjl.3,p.V353I|ENST00000397267,p.V353I|uc001wjm.3,p.V353I|NM_020372,p.V353I|uc010akk.3,p.V135I|ENST00000354772,p.V353I|NM_016609,p.V353I|ENST00000397260,p.V242I|NM_001289050,p.V135I	retained_intron, protein_coding, processed_transcript	uc010akk.3	nonsynonymous SNV	exon7	c.G403A	p.V135I	SLLASGTAALACVFLGVTVDRFGRR	SLLASGTAALACIFLGVTVDRFGRR	6.0	6.0	-	-	4284_14:23816828-23816828 C>T_SLLASGTAALACIFLGVTVDRFGRR	0.0
5:79282875-79282875 G>A	1.0	4345	COLORECTAL	0.0037	-	-	-	MTX3	ENST00000509852,p.R213W|uc003kge.4,p.R152W|uc010jah.3,p.R213W|NM_001167741,p.R152W|ENST00000512560,p.R152W|NM_001010891,p.R213W|uc010jag.3,p.R213W|ENST00000512528,p.R213W	protein_coding	uc010jah.3	nonsynonymous SNV	exon7	c.C637T	p.R213W	YVFGFLAPLYKVRFPKVQLQEHLKQ	YVFGFLAPLYKVWFPKVQLQEHLKQ	4.0	3.0	-	-	4345_5:79282875-79282875 G>A_YVFGFLAPLYKVWFPKVQLQEHLKQ	0.0
X:26158083-26158083 G>C	0.0	4284	COLORECTAL	-	-	-	-	MAGEB18	uc004dbq.2,p.M327I|uc022bub.1,p.M327I|NM_173699,p.M327I|ENST00000325250,p.M327I	protein_coding	uc022bub.1	nonsynonymous SNV	exon1	c.G981C	p.M327I	QARAAARAHTAAMANARSRTTSSSF	QARAAARAHTAAIANARSRTTSSSF	1.0	10.0	-	-	4284_X:26158083-26158083 G>C_QARAAARAHTAAIANARSRTTSSSF	0.0
X:72433818-72433818 C>A	0.0	4126	NSCLC	-	-	-	-	NAP1L2	uc004ebi.3,p.D171Y|ENST00000536638,p.D29Y|NM_021963,p.D171Y|ENST00000373517,p.D171Y	protein_coding	uc004ebi.3	nonsynonymous SNV	exon1	c.G511T	p.D171Y	YEPTEEECEYKSDSEDCDDEEMCHE	YEPTEEECEYKSYSEDCDDEEMCHE	1.0	10.0	-	-	4126_X:72433818-72433818 C>A_YEPTEEECEYKSYSEDCDDEEMCHE	0.0
9:131355267-131355267 G>A	1.0	4180	BREAST	-	-	-	-	SPTAN1	ENST00000372731,p.R1054H|NM_001130438,p.R1054H|uc004bvm.4,p.R1054H|ENST00000372739,p.R1054H|ENST00000358161,p.R1054H|NM_003127,p.R1054H|uc011mbh.2,p.R1066H|uc004bvl.4,p.R1054H	protein_coding, processed_transcript	uc011mbh.2	nonsynonymous SNV	exon24	c.G3197A	p.R1066H	IALRQEQIDNQTRITKEAGSVSLRM	IALRQEQIDNQTHITKEAGSVSLRM	10.0	9.0	-	-	4180_9:131355267-131355267 G>A_IALRQEQIDNQTHITKEAGSVSLRM	0.0
2:203847102-203847102 G>A	1.0	4284	COLORECTAL	-	-	-	-	CARF	ENST00000545253,p.R578Q|ENST00000438828,p.R666Q|uc002uzp.2,p.R666Q|NM_001282912,p.R578Q|NM_001282911,p.R590Q|uc002uzo.2,p.R666Q|ENST00000402905,p.R666Q|uc010zia.1,p.R590Q|ENST00000414439,p.R564Q|uc010zic.1,p.R578Q|NM_001282910,p.R590Q|ENST00000428585,p.R590Q|NM_001104586,p.R666Q|ENST00000320443,p.R666Q|ENST00000545262,p.R590Q|uc010zib.1,p.R590Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zic.1	nonsynonymous SNV	exon13	c.G1733A	p.R578Q	VEDTGNLEGTVHRILLGDVQTIPIQ	VEDTGNLEGTVHQILLGDVQTIPIQ	7.0	2.0	-	-	4284_2:203847102-203847102 G>A_VEDTGNLEGTVHQILLGDVQTIPIQ	0.0
5:140574170-140574175 AGGCCG>-	0.0	4234	NSCLC	-	rs111745700	ID=COSM1486391;OCCURENCE=2(breast)	-	PCDHB10	uc003lix.3,p.682_684del|NM_018930,p.682_684del|ENST00000239446,p.682_684del	protein_coding	uc003lix.3	nonframeshift deletion	exon1	c.2045_2050del	p.682_684del	YLPLPEAAPAQAQAEADLLTVYLVVA	YLPLPEAAPAQAQADLLTVYLVVAL	6.0	1.0	-	-	4234_5:140574170-140574175 AGGCCG>-_YLPLPEAAPAQAQADLLTVYLVVAL	0.0
17:27229914-27229914 G>A	0.0	4240	BREAST	-	-	-	-	DHRS13	uc010wba.2,p.L17F|NM_144683,p.L17F|ENST00000378895,p.L17F|ENST00000426464,p.L17F|uc002hde.4,p.L17F	retained_intron, protein_coding, processed_transcript	uc010wba.2	nonsynonymous SNV	exon1	c.C49T	p.L17F	LLGAGLLLGAYVLVYYNLVKAPPCG	LLGAGLLLGAYVFVYYNLVKAPPCG	9.0	2.0	-	-	4240_17:27229914-27229914 G>A_LLGAGLLLGAYVFVYYNLVKAPPCG	0.0
12:46244034-46244034 C>T	1.0	4301	MELANOMA	-	-	ID=COSM1167994;OCCURENCE=1(skin)	1	ARID2	ENST00000422737,p.P561S|uc001ror.3,p.P710S|uc001rou.1,p.P44S|ENST00000444670,p.P320S|uc009zkh.1,p.P337S|NM_152641,p.P710S|uc009zkg.1,p.P166S|uc001ros.1,p.P710S|ENST00000334344,p.P710S	retained_intron, protein_coding, processed_transcript	uc009zkh.1	nonsynonymous SNV	exon7	c.C1009T	p.P337S	APVTVIQSKAPIPCEVVKATVIQNS	APVTVIQSKAPISCEVVKATVIQNS	8.0	4.0	-	-	4301_12:46244034-46244034 C>T_APVTVIQSKAPISCEVVKATVIQNS	0.0
3:42741254-42741254 T>G	0.0	4213	COLORECTAL	-	-	-	-	HHATL	ENST00000310417,p.K57T|uc003clw.3,p.K57T|ENST00000457462,p.K57T|ENST00000416756,p.K57T|ENST00000417472,p.K57T|ENST00000442469,p.K57T|uc003clx.3,p.K57T|NM_020707,p.K57T|ENST00000441594,p.K57T|ENST00000455195,p.K57T	retained_intron, protein_coding	uc003clx.3	nonsynonymous SNV	exon3	c.A170C	p.K57T	ESVRPGWEYIGRKMDVADFEWVMWF	ESVRPGWEYIGRTMDVADFEWVMWF	3.0	6.0	-	-	4213_3:42741254-42741254 T>G_ESVRPGWEYIGRTMDVADFEWVMWF	0.0
12:117723970-117723970 ->CCCCA	0.0	4316	COLORECTAL	-	-	-	-	NOS1	uc001twn.2,p.A410fs|uc001twm.2,p.A410fs|NM_001204214,p.A74fs|NM_001204213,p.A74fs|ENST00000338101,p.A410fs|NM_000620,p.A410fs|uc021ren.1,p.A74fs|ENST00000317775,p.A410fs|NM_001204218,p.A410fs|uc021reo.1,p.A74fs	protein_coding, processed_transcript	uc021reo.1	frameshift insertion	exon5	c.220_221insTGGGG	p.A74fs	TYQLKDTELIYGAKHAWRNASRCVG	TYQLKDTELIYGVGPSTPGGMPRAVWAGSSGPSCRYSMPVTAPRPTGCSTTSVTMSSMPPTKGTSGLPSPYSPRGQTASTTSESGTPSSSATLATSSLTAPPWGTQPMCSSQRYAYSRAGNRLEAASMSCRSCFRPTAMTLSSSRFLQSWCWKFPSGTPSLSGSRTWG	1.0	1.0	-	-	4316_12:117723970-117723970 ->CCCCA_TYQLKDTELIYGVGPSTPGGMPRAVWAGSSGPSCRYSMPVTAPRPTGCSTTSVTMSSMPPTKGTSGLPSPYSPRGQTASTTSESGTPSSSATLATSSLTAPPWGTQPMCSSQRYAYSRAGNRLEAASMSCRSCFRPTAMTLSSSRFLQSWCWKFPSGTPSLSGSRTWG	0.0
16:8993493-8993493 C>T	1.0	4046	OVARIAN	-	-	-	-	USP7	uc010uyk.1,p.V712I|NM_003470,p.V811I|uc002czk.2,p.V795I|uc010uyj.1,p.V712I|NM_001286457,p.V795I|uc002czl.2,p.V811I|NM_001286458,p.V712I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uyk.1	nonsynonymous SNV	exon23	c.G2134A	p.V712I	CDKTIPNDPGFVVTLSNRMNYFQVA	CDKTIPNDPGFVITLSNRMNYFQVA	9.0	6.0	-	-	4046_16:8993493-8993493 C>T_CDKTIPNDPGFVITLSNRMNYFQVA	0.0
20:42089231-42089231 C>T	1.0	2369	MELANOMA	-	-	-	-	SRSF6	NM_006275,p.R223C|ENST00000244020,p.R223C|uc010zwg.2,p.R223C|uc002xki.3,p.R94C	protein_coding, nonsense_mediated_decay	uc010zwg.2	nonsynonymous SNV	exon5	c.C667T	p.R223C	SSRSRSRSISKSRSRSRSRSKGRSR	SSRSRSRSISKSCSRSRSRSKGRSR	10.0	8.0	-	-	2369_20:42089231-42089231 C>T_SSRSRSRSISKSCSRSRSRSKGRSR	0.0
7:150725677-150725677 C>G	1.0	4134	NSCLC	-	-	-	-	ABCB8	uc003wik.4,p.F25L|ENST00000498578,p.F25L|ENST00000477092,p.F25L|NM_001282292,p.F25L|ENST00000477719,p.F25L|ENST00000358849,p.F25L|NM_007188,p.F25L|uc010lpx.3,p.F25L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010lpx.3	nonsynonymous SNV	exon1	c.C75G	p.F25L	GPFPGRLLPPLRFQTFSAVRYSDGY	GPFPGRLLPPLRLQTFSAVRYSDGY	7.0	6.0	-	-	4134_7:150725677-150725677 C>G_GPFPGRLLPPLRLQTFSAVRYSDGY	0.0
17:78320426-78320426 C>T	1.0	3903	MELANOMA	-	-	-	1	RNF213	ENST00000336301,p.P837L|ENST00000508628,p.P2813L|ENST00000582970,p.P2764L|NM_001256071,p.P2764L|uc021uen.2,p.P2764L	retained_intron, protein_coding, processed_transcript	uc021uen.2	nonsynonymous SNV	exon29	c.C8291T	p.P2764L	VFMMVVCIELKIPLFLVGKPGSSKS	VFMMVVCIELKILLFLVGKPGSSKS	10.0	8.0	-	-	3903_17:78320426-78320426 C>T_VFMMVVCIELKILLFLVGKPGSSKS	0.0
5:82948397-82948397 C>T	0.0	4287	COLORECTAL	-	-	-	-	HAPLN1	ENST00000503117,p.G115E|uc003kin.3,p.G116E|ENST00000274341,p.G116E|ENST00000515590,p.G116E|ENST00000504713,p.G116E|ENST00000510978,p.G116E|ENST00000508307,p.G116E|ENST00000514416,p.G116E|NM_001884,p.G116E|uc003kim.3,p.G116E	protein_coding	uc003kin.3	nonsynonymous SNV	exon3	c.G347A	p.G116E	TYGGYQGRVFLKGGSDSDASLVITD	TYGGYQGRVFLKEGSDSDASLVITD	2.0	10.0	-	-	4287_5:82948397-82948397 C>T_TYGGYQGRVFLKEGSDSDASLVITD	0.0
19:33119731-33119731 C>T	1.0	3903	MELANOMA	-	-	-	-	ANKRD27	uc002ntn.1,p.E412K|ENST00000591100,p.E106K|ENST00000306065,p.E412K|NM_032139,p.E412K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002ntn.1	nonsynonymous SNV	exon14	c.G1234A	p.E412K	CLFKHIASGNQKEVERLLSQEDHDK	CLFKHIASGNQKKVERLLSQEDHDK	6.0	3.0	-	-	3903_19:33119731-33119731 C>T_CLFKHIASGNQKKVERLLSQEDHDK	0.0
12:11091682-11091682 G>A	0.0	4301	MELANOMA	-	-	-	-	TAS2R14	ENST00000537503,p.S42F|uc010shi.2,p.S42F|NM_023922,p.S42F	protein_coding, processed_transcript	uc010shi.2	nonsynonymous SNV	exon1	c.C125T	p.S42F	VNCIDWVKGRKISSVDRILTALAIS	VNCIDWVKGRKIFSVDRILTALAIS	6.0	9.0	-	-	4301_12:11091682-11091682 G>A_VNCIDWVKGRKIFSVDRILTALAIS	0.0
5:14461179-14461179 C>T	1.0	3713	MELANOMA	-	-	-	-	TRIO	ENST00000344204,p.S1752F|uc003jff.3,p.S1752F|ENST00000537187,p.S1752F|uc003jfh.1,p.S1401F|ENST00000512070,p.S1693F|NM_007118,p.S1752F|ENST00000513206,p.S1485F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jfh.1	nonsynonymous SNV	exon30	c.C4202T	p.S1401F	SSNDASPPASVASLQPHMIGAQSSP	SSNDASPPASVAFLQPHMIGAQSSP	6.0	8.0	-	-	3713_5:14461179-14461179 C>T_SSNDASPPASVAFLQPHMIGAQSSP	0.0
2:166848014-166848014 C>T	0.0	4281	COLORECTAL	-	-	-	-	SCN1A	uc021vsb.1,p.R1913H|ENST00000423058,p.R1924H|NM_001165963,p.R1924H|NM_001165964,p.R1896H|ENST00000375405,p.R1913H|NM_001202435,p.R1924H|ENST00000303395,p.R1924H|ENST00000409050,p.R1896H|uc010fpk.3,p.R1896H|NM_006920,p.R1913H|uc002udo.4,p.R1924H	retained_intron, protein_coding	uc021vsb.1	nonsynonymous SNV	exon26	c.G5738A	p.R1913H	RKQEEVSAVIIQRAYRRHLLKRTVK	RKQEEVSAVIIQHAYRRHLLKRTVK	1.0	4.0	-	-	4281_2:166848014-166848014 C>T_RKQEEVSAVIIQHAYRRHLLKRTVK	0.0
19:22496907-22496907 C>T	0.0	3466	MELANOMA	-	-	-	-	ZNF729	NM_001242680,p.H230Y|uc021urs.1,p.H230Y|ENST00000601693,p.H230Y|ENST00000357491,p.H230Y	protein_coding	uc021urs.1	nonsynonymous SNV	exon4	c.C688T	p.H230Y	KSFSTLTKHKIIHTEDKPYKYKKCG	KSFSTLTKHKIIYTEDKPYKYKKCG	1.0	8.0	-	-	3466_19:22496907-22496907 C>T_KSFSTLTKHKIIYTEDKPYKYKKCG	0.0
14:79432748-79432748 G>T	0.0	4326	BREAST	-	-	-	-	NRXN3	ENST00000335750,p.G553W|uc010asv.1,p.G678W|ENST00000554738,p.G915W|ENST00000554719,p.G553W|NM_004796,p.G553W|uc001xun.4,p.G553W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010asv.1	nonsynonymous SNV	exon8	c.G2032T	p.G678W	DGNDFIAVELVKGYIHYVFDLGNGP	DGNDFIAVELVKWYIHYVFDLGNGP	4.0	4.0	-	-	4326_14:79432748-79432748 G>T_DGNDFIAVELVKWYIHYVFDLGNGP	0.0
10:119307700-119307700 A>C	1.0	4284	COLORECTAL	-	-	-	-	EMX2	uc001ldh.4,p.K239T|NM_004098,p.K239T|ENST00000553456,p.K239T	protein_coding, processed_transcript	uc001ldh.4	nonsynonymous SNV	exon3	c.A716C	p.K239T	GTHHINRWRIATKQASPEEIDVTSD	GTHHINRWRIATTQASPEEIDVTSD	2.0	8.0	-	-	4284_10:119307700-119307700 A>C_GTHHINRWRIATTQASPEEIDVTSD	0.0
19:19748851-19748851 C>A	1.0	4046	OVARIAN	-	-	-	-	GMIP	uc010xrb.2,p.A269S|uc010xrc.2,p.A269S|ENST00000203556,p.A269S|ENST00000587238,p.A269S|NM_001288999,p.A269S|NM_001288998,p.A269S|NM_016573,p.A269S|ENST00000445806,p.A269S|uc002nnd.3,p.A269S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xrc.2	nonsynonymous SNV	exon10	c.G805T	p.A269S	REEAQAKAQEAEALYQACVREANAR	REEAQAKAQEAESLYQACVREANAR	7.0	9.0	-	-	4046_19:19748851-19748851 C>A_REEAQAKAQEAESLYQACVREANAR	0.0
1:21106903-21106903 C>T	1.0	4213	COLORECTAL	-	-	-	-	HP1BP3	uc001bea.2,p.V11I|uc001beb.3,p.V11I|uc001bdw.1,p.V11I|uc001bdy.1,p.V11I|ENST00000417710,p.V11I|ENST00000414993,p.V11I|ENST00000438032,p.V11I|ENST00000375000,p.V11I|NM_016287,p.V11I|ENST00000312239,p.V11I	protein_coding, processed_transcript	uc001beb.3	nonsynonymous SNV	exon2	c.G31A	p.V11I	MATDTSQGELVHPKALPLIVGAQ	MATDTSQGELIHPKALPLIVGAQ	10.0	7.0	-	-	4213_1:21106903-21106903 C>T_MATDTSQGELIHPKALPLIVGAQ	0.0
11:1101090-1101090 G>A	0.0	4246	COLORECTAL	-	-	ID=COSM428397;OCCURENCE=1(breast)	-	MUC2	ENST00000441003,p.V2497I	protein_coding	ENST00000441003	nonsynonymous SNV	exon41	c.G7489A	p.V2497I	IICQPKRCSQKPVTHCVEDGTYLAT	IICQPKRCSQKPITHCVEDGTYLAT	3.0	8.0	-	-	4246_11:1101090-1101090 G>A_IICQPKRCSQKPITHCVEDGTYLAT	0.0
16:2140509-2140509 A>C	1.0	2556	MELANOMA	-	-	-	-	PKD1	uc002cot.1,p.L4073R|ENST00000423118,p.L4073R|ENST00000262304,p.L4074R|uc002cos.1,p.L4074R|NM_000296,p.L4073R|NM_001009944,p.L4074R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002cot.1	nonsynonymous SNV	exon45	c.T12218G	p.L4073R	LLVLCPGTGLSTLCPAESWHLSPLL	LLVLCPGTGLSTRCPAESWHLSPLL	8.0	4.0	-	-	2556_16:2140509-2140509 A>C_LLVLCPGTGLSTRCPAESWHLSPLL	0.0
2:71212240-71212240 T>A	0.0	4298	COLORECTAL	-	-	-	-	ANKRD53	ENST00000360589,p.M468K|NM_001115116,p.M468K|uc002shl.4,p.M468K|ENST00000457410,p.M434K	retained_intron, protein_coding	uc002shl.4	nonsynonymous SNV	exon6	c.T1403A	p.M468K	LRMLYPRVWPYRMKVPQGFYPISMR	LRMLYPRVWPYRKKVPQGFYPISMR	2.0	4.0	-	-	4298_2:71212240-71212240 T>A_LRMLYPRVWPYRKKVPQGFYPISMR	0.0
19:22256320-22256320 A>T	0.0	4196	COLORECTAL	-	-	-	-	ZNF257	uc010ecx.3,p.K60N|uc010ecy.3,p.K28N|ENST00000600162,p.K60N|ENST00000594947,p.K60N|NM_033468,p.K60N|ENST00000594363,p.K60N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ecy.3	nonsynonymous SNV	exon4	c.A84T	p.K28N	SKPDLITCLEQGKEPCNMKRHEMVA	SKPDLITCLEQGNEPCNMKRHEMVA	7.0	5.0	-	-	4196_19:22256320-22256320 A>T_SKPDLITCLEQGNEPCNMKRHEMVA	0.0
X:50350613-50350613 C>T	0.0	4301	MELANOMA	-	-	-	-	SHROOM4	ENST00000376020,p.E1177K|ENST00000460112,p.E1061K|ENST00000289292,p.E1177K|NM_020717,p.E1177K|uc004dpe.2,p.E1177K	protein_coding, processed_transcript	uc004dpe.2	nonsynonymous SNV	exon6	c.G3529A	p.E1177K	SSETSGSCALNPEEVLEQPQPLSFG	SSETSGSCALNPKEVLEQPQPLSFG	6.0	9.0	-	-	4301_X:50350613-50350613 C>T_SSETSGSCALNPKEVLEQPQPLSFG	0.0
1:16464527-16464527 G>A	1.0	3466	MELANOMA	-	-	-	-	EPHA2	NM_004431,p.P378L|ENST00000358432,p.P378L|uc010oca.2,p.P378L|uc001aya.2,p.P378L	protein_coding, processed_transcript	uc010oca.2	nonsynonymous SNV	exon5	c.C1133T	p.P378L	CEQCWPESGECGPCEASVRYSEPPH	CEQCWPESGECGLCEASVRYSEPPH	7.0	2.0	-	-	3466_1:16464527-16464527 G>A_CEQCWPESGECGLCEASVRYSEPPH	0.0
12:25398285-25398285 C>A	1.0	4245	COLORECTAL	-	-	ID=COSM1140136,COSM516;OCCURENCE=15(stomach),1(central_nervous_system),8(upper_aerodigestive_tract),2(oesophagus),3(peritoneum),1776(lung),18(thyroid),17(haematopoietic_and_lymphoid_tissue),2(testis),2(cervix),4(gastrointestinal_tract_(site_indeterminate)),13(soft_tissue),34(ovary),38(endometrium),5(skin),11(breast),8(small_intestine),1(kidney),130(pancreas),4(liver),15(urinary_tract),1(adrenal_gland),1476(large_intestine),51(biliary_tract),10(prostate)	1	KRAS	uc001rgq.1,p.G12C|uc001rgp.1,p.G12C|ENST00000556131,p.G12C|ENST00000557334,p.G12C|NM_004985,p.G12C|ENST00000311936,p.G12C|NM_033360,p.G12C|ENST00000256078,p.G12C	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G34T	p.G12C	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGACGVGKSALTIQLI	7.0	10.0	-	-	4245_12:25398285-25398285 C>A_MTEYKLVVVGACGVGKSALTIQLI	0.0
9:35677850-35677850 G>A	1.0	3903	MELANOMA	-	-	-	-	CA9	ENST00000378357,p.E302K|uc003zxo.4,p.E302K|NM_001216,p.E302K	protein_coding, processed_transcript	uc003zxo.4	nonsynonymous SNV	exon6	c.G904A	p.E302K	EQLLSRLEEIAEEGSETQVPGLDIS	EQLLSRLEEIAEKGSETQVPGLDIS	4.0	10.0	-	-	3903_9:35677850-35677850 G>A_EQLLSRLEEIAEKGSETQVPGLDIS	0.0
16:58619389-58619389 G>A	1.0	2369	MELANOMA	-	-	-	-	CNOT1	NM_016284,p.P220L|NM_001265612,p.P220L|uc002enx.4,p.P220L|uc002enu.5,p.P220L|NM_206999,p.P220L|ENST00000317147,p.P220L|uc002env.4,p.P220L|ENST00000567188,p.P220L|ENST00000569240,p.P220L|ENST00000441024,p.P220L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002enx.4	nonsynonymous SNV	exon8	c.C659T	p.P220L	KTLRRDFPQERCPVVLAPLLYPEKR	KTLRRDFPQERCLVVLAPLLYPEKR	10.0	9.0	-	-	2369_16:58619389-58619389 G>A_KTLRRDFPQERCLVVLAPLLYPEKR	0.0
10:72492109-72492109 G>T	0.0	4281	COLORECTAL	-	-	-	-	ADAMTS14	NM_080722,p.G401V|ENST00000373208,p.G404V|NM_139155,p.G404V|ENST00000373207,p.G401V|uc001jrg.3,p.G404V|uc001jrh.3,p.G401V	protein_coding	uc001jrh.3	nonsynonymous SNV	exon7	c.G1202T	p.G401V	GFSSAFVIAHETGHVLGMEHDGQGN	GFSSAFVIAHETVHVLGMEHDGQGN	4.0	8.0	-	-	4281_10:72492109-72492109 G>T_GFSSAFVIAHETVHVLGMEHDGQGN	0.0
19:3765238-3765238 C>T	1.0	3466	MELANOMA	-	-	-	-	MRPL54	uc002lyq.4,p.P65S|NM_172251,p.P65S|ENST00000330133,p.P65S	protein_coding	uc002lyq.4	nonsynonymous SNV	exon2	c.C193T	p.P65S	SEALKDPDVCTDPVQLTTYAMGVNI	SEALKDPDVCTDSVQLTTYAMGVNI	5.0	7.0	-	-	3466_19:3765238-3765238 C>T_SEALKDPDVCTDSVQLTTYAMGVNI	0.0
19:42573044-42573044 G>A	0.0	4046	OVARIAN	-	-	-	-	GRIK5,ZNF574	ENST00000222339,p.E61K|uc002osk.4,p.E61K	protein_coding	uc002osk.4	nonsynonymous SNV	exon1	c.G181A	p.E61K	AHRRQRMRLRGTERASLGPGRRLGD	AHRRQRMRLRGTKRASLGPGRRLGD	7.0	4.0	-	-	4046_19:42573044-42573044 G>A_AHRRQRMRLRGTKRASLGPGRRLGD	0.0
17:80356167-80356167 G>A	1.0	4000	MELANOMA	-	-	-	-	OGFOD3	NM_024648,p.S243L|uc002ket.2,p.S243L|ENST00000313056,p.S243L|uc002keu.2,p.S243L|NM_175902,p.S243L|ENST00000329197,p.S243L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002keu.2	nonsynonymous SNV	exon8	c.C728T	p.S243L	VDKVTYGSFDYTSLLYLSNYLEDFG	VDKVTYGSFDYTLLLYLSNYLEDFG	7.0	7.0	-	-	4000_17:80356167-80356167 G>A_VDKVTYGSFDYTLLLYLSNYLEDFG	0.0
7:140453125-140453125 A>C, 7:140453136-140453136 A>T	1.0	4301	MELANOMA	-	-	ID=COSM476;OCCURENCE=3(adrenal_gland),3(urinary_tract),4(genital_tract),7(pancreas),16(liver),68(eye),2(prostate),4161(large_intestine),21(biliary_tract),11(breast),4377(skin),9(small_intestine),1(autonomic_ganglia),20(pituitary),242(ovary),32(soft_tissue),7(testis),459(haematopoietic_and_lymphoid_tissue),9534(thyroid),78(lung),1(meninges),12(upper_aerodigestive_tract),717(NS),15(bone),2(oesophagus),4(stomach),228(central_nervous_system)	1	BRAF	NM_004333,p.V600E|uc003vwc.4,p.V600E|ENST00000288602,p.V600E|ENST00000479537,p.V28E	retained_intron, protein_coding, nonsense_mediated_decay	uc003vwc.4	nonsynonymous SNV	exon15	c.T1799A, c.T1810G	p.V600E, p.W604G	LTVKIGDFGLATVKSRWSGSHQFEQ	LTVKIGDFGLATEKSRGSGSHQFEQ	8.0	10.0	-	Additional variant within 36 nucleotides, 7:140453125-140453125 A>C PR, residue 17 W>G PR	4301_7:140453125-140453125 A>C, 7:140453136-140453136 A>T_LTVKIGDFGLATEKSRGSGSHQFEQ	0.0
21:32007751-32007751 G>A	0.0	3903	MELANOMA	-	-	-	-	KRTAP20-2	uc011adg.2,p.G57R|ENST00000330798,p.G57R|NM_181616,p.G57R	protein_coding	uc011adg.2	nonsynonymous SNV	exon1	c.G169A	p.G57R	GYGYGCCRPSCYGRYWSCGFY	GYGYGCCRPSCYRRYWSCGFY	1.0	9.0	-	-	3903_21:32007751-32007751 G>A_GYGYGCCRPSCYRRYWSCGFY	0.0
19:59025437-59025437 G>A	0.0	4078	GASTRIC	-	-	-	-	ZBTB45	uc002qtf.3,p.A507V|ENST00000600990,p.A507V|ENST00000594051,p.A507V|ENST00000354590,p.A507V|NM_032792,p.A507V|uc002qtd.3,p.A507V	protein_coding	uc002qtf.3	nonsynonymous SNV	exon3	c.C1520T	p.A507V	FSHRALLERHLAAHPAP	FSHRALLERHLAVHPAP	5.0	8.0	-	-	4078_19:59025437-59025437 G>A_FSHRALLERHLAVHPAP	0.0
6:163735867-163735867 G>A	1.0	4252	COLORECTAL	-	-	-	-	PACRG	ENST00000366888,p.G208R|uc003qub.3,p.G208R|NM_001080379,p.G208R|uc003quc.3,p.G208R|ENST00000366889,p.G208R|NM_001080378,p.G208R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003quc.3	nonsynonymous SNV	exon5	c.G622A	p.G208R	VLNIFKNMNVNSGDGIDYSQQKREN	VLNIFKNMNVNSRDGIDYSQQKREN	6.0	8.0	-	-	4252_6:163735867-163735867 G>A_VLNIFKNMNVNSRDGIDYSQQKREN	0.0
5:136975627-136975627 G>A	1.0	4301	MELANOMA	-	-	-	-	KLHL3	uc010jem.1,p.R275C|uc011cyc.2,p.R84C|uc010jel.1,p.R84C|ENST00000309755,p.R315C|uc010jek.3,p.R315C|ENST00000506491,p.R233C|uc003lbr.5,p.R233C|NM_001257195,p.R233C|ENST00000505853,p.R275C|NM_001257194,p.R283C|uc031sle.1,p.R283C|ENST00000508657,p.R283C|NM_017415,p.R315C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031sle.1	nonsynonymous SNV	exon9	c.C847T	p.R283C	MIVVGGQAPKAIRSVECYDFEEDRW	MIVVGGQAPKAICSVECYDFEEDRW	7.0	4.0	-	-	4301_5:136975627-136975627 G>A_MIVVGGQAPKAICSVECYDFEEDRW	0.0
16:30977066-30977066 C>T	1.0	3919	MELANOMA	-	-	-	-	SETD1A	NM_014712,p.P622S|ENST00000262519,p.P622S|uc002ead.1,p.P622S	protein_coding	uc002ead.1	nonsynonymous SNV	exon8	c.C1864T	p.P622S	PPPPPPPYLASLPLGYPPHQPAYLL	PPPPPPPYLASLSLGYPPHQPAYLL	6.0	8.0	-	-	3919_16:30977066-30977066 C>T_PPPPPPPYLASLSLGYPPHQPAYLL	0.0
12:42859010-42859010 C>T	1.0	3903	MELANOMA	-	-	-	-	PRICKLE1	ENST00000345127,p.E276K|uc010skw.2,p.E276K|uc001rnl.3,p.E276K|ENST00000552240,p.E276K|ENST00000548696,p.E276K|ENST00000455697,p.E276K|NM_001144882,p.E276K|uc010skv.2,p.E276K|NM_001144881,p.E276K|uc001rnm.3,p.E276K|NM_001144883,p.E276K|ENST00000445766,p.E276K|NM_153026,p.E276K	protein_coding, processed_transcript	uc010skw.2	nonsynonymous SNV	exon7	c.G826A	p.E276K	QMTYDGQHWHATEACFSCAQCKASL	QMTYDGQHWHATKACFSCAQCKASL	6.0	9.0	-	-	3903_12:42859010-42859010 C>T_QMTYDGQHWHATKACFSCAQCKASL	0.0
13:46708375-46708375 T>G	0.0	4129	NSCLC	-	-	-	2	LCP1	ENST00000323076,p.N505H|uc001vay.4,p.N102H|ENST00000398576,p.N505H|NM_002298,p.N505H|ENST00000435666,p.N74H|uc010ack.3,p.N74H|uc001vba.4,p.N505H|uc001vaz.4,p.N505H	protein_coding, processed_transcript	uc010ack.3	nonsynonymous SNV	exon3	c.A220C	p.N74H	ALIWQLMRRYTLNILEEIGGGQKVN	ALIWQLMRRYTLHILEEIGGGQKVN	9.0	4.0	-	-	4129_13:46708375-46708375 T>G_ALIWQLMRRYTLHILEEIGGGQKVN	0.0
5:178140326-178140326 T>G	0.0	4345	COLORECTAL	-	-	-	-	ZNF354A	ENST00000335815,p.T185P|NM_005649,p.T185P|uc003mjj.3,p.T185P	protein_coding, nonsense_mediated_decay	uc003mjj.3	nonsynonymous SNV	exon5	c.A553C	p.T185P	VLIRQQILPREKTPPKCEIQGNSLK	VLIRQQILPREKPPPKCEIQGNSLK	6.0	4.0	-	-	4345_5:178140326-178140326 T>G_VLIRQQILPREKPPPKCEIQGNSLK	0.0
11:107224460-107224460 A>T	1.0	3713	MELANOMA	-	-	-	-	CWF19L2	NM_152434,p.F625L|uc010rvp.2,p.F625L|ENST00000433523,p.F625L|ENST00000282251,p.F625L|ENST00000431778,p.F506L	retained_intron, protein_coding, nonsense_mediated_decay	uc010rvp.2	nonsynonymous SNV	exon13	c.T1875A	p.F625L	NQNKLFMRMASKFMGKTDGDYYTLD	NQNKLFMRMASKLMGKTDGDYYTLD	4.0	6.0	-	-	3713_11:107224460-107224460 A>T_NQNKLFMRMASKLMGKTDGDYYTLD	0.0
6:152655269-152655269 C>T	1.0	4189	MELANOMA	-	-	ID=COSM3430206,COSM1441446,COSM32658,COSM1441445,COSM3430205;OCCURENCE=1(central_nervous_system),5(large_intestine)	-	SYNE1	ENST00000367255,p.R4223H|uc003qot.4,p.R4152H|ENST00000448038,p.R4152H|uc003qou.4,p.R4223H|NM_033071,p.R4152H|ENST00000265368,p.R4223H|ENST00000341594,p.R4088H|NM_182961,p.R4223H|ENST00000423061,p.R4152H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003qou.4	nonsynonymous SNV	exon77	c.G12668A	p.R4223H	INHLNDQWLDLCRQSNNLCLQREED	INHLNDQWLDLCHQSNNLCLQREED	9.0	8.0	-	-	4189_6:152655269-152655269 C>T_INHLNDQWLDLCHQSNNLCLQREED	0.0
12:130941188-130941188 G>T	0.0	4160	COLORECTAL	-	-	-	-	RIMBP2	NM_015347,p.L54M|uc001uil.2,p.L54M|ENST00000261655,p.L54M	retained_intron, protein_coding, nonsense_mediated_decay	uc001uil.2	nonsynonymous SNV	exon4	c.C160A	p.L54M	EKCRTQSEQFNLLSRDLEKFRQHAG	EKCRTQSEQFNLMSRDLEKFRQHAG	4.0	7.0	-	-	4160_12:130941188-130941188 G>T_EKCRTQSEQFNLMSRDLEKFRQHAG	0.0
1:229438680-229438680 C>T	1.0	4037	NSCLC	-	-	-	-	RAB4A	uc031psp.1,p.P100S|uc001hth.4,p.P205S|ENST00000366690,p.P205S|NM_004578,p.P205S|NM_001271998,p.P100S	retained_intron, protein_coding, processed_transcript	uc031psp.1	nonsynonymous SNV	exon5	c.C298T	p.P100S	QYGDAALRQLRSPRRAQAPNAQECG	QYGDAALRQLRSSRRAQAPNAQECG	8.0	10.0	-	-	4037_1:229438680-229438680 C>T_QYGDAALRQLRSSRRAQAPNAQECG	0.0
3:49160445-49160445 G>A	1.0	2556	MELANOMA	-	-	-	-	LAMB2	NM_002292,p.P1422L|uc003cwe.3,p.P1422L|ENST00000305544,p.P1422L|ENST00000418109,p.P1422L	retained_intron, protein_coding, processed_transcript	uc003cwe.3	nonsynonymous SNV	exon27	c.C4265T	p.P1422L	CGAPGDAPCATSPCGGAGCRDEDGQ	CGAPGDAPCATSLCGGAGCRDEDGQ	10.0	8.0	-	-	2556_3:49160445-49160445 G>A_CGAPGDAPCATSLCGGAGCRDEDGQ	0.0
16:58580402-58580402 A>C	1.0	3919	MELANOMA	-	-	-	-	CNOT1	uc002enx.4,p.L1277V|ENST00000569240,p.L1272V|NM_206999,p.L1277V|ENST00000317147,p.L1277V|uc010vik.3,p.L234V|ENST00000441024,p.L1277V|ENST00000245138,p.L128V|NM_016284,p.L1277V|ENST00000567188,p.L1272V|uc002enu.5,p.L1272V|uc002env.4,p.L1277V|NM_001265612,p.L1272V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vik.3	nonsynonymous SNV	exon6	c.T700G	p.L234V	VLAELHQEHDLKLNLKFEIEVLCKN	VLAELHQEHDLKVNLKFEIEVLCKN	9.0	8.0	-	-	3919_16:58580402-58580402 A>C_VLAELHQEHDLKVNLKFEIEVLCKN	0.0
2:79971627-79971627 G>A	0.0	4301	MELANOMA	-	-	-	2	CTNNA2	uc010ysg.2,p.E73K|ENST00000361291,p.E107K|NM_001282598,p.E107K|uc010ysh.2,p.E73K|ENST00000541047,p.E73K|uc010ysf.2,p.E73K|NM_001164883,p.E73K|ENST00000540488,p.E73K|NM_004389,p.E73K|uc010yse.2,p.E73K|ENST00000466387,p.E73K|ENST00000409971,p.E73K|ENST00000402739,p.E73K|NM_001282597,p.E73K|ENST00000496558,p.E73K	retained_intron, protein_coding, processed_transcript	uc010ysh.2	nonsynonymous SNV	exon2	c.G217A	p.E73K	AASVEQATQNFLEKGEQIAKESQDL	AASVEQATQNFLKKGEQIAKESQDL	4.0	8.0	-	-	4301_2:79971627-79971627 G>A_AASVEQATQNFLKKGEQIAKESQDL	0.0
12:29709817-29709826 GCCCGGTTAT>-	0.0	4252	COLORECTAL	-	-	-	-	TMTC1	ENST00000256062,p.H439fs|NM_001193451,p.H547fs|uc001rjc.1,p.H501fs|ENST00000552618,p.H571fs|uc001rjb.3,p.H439fs|uc001riz.3,p.H196fs|uc021qwi.1,p.H547fs|ENST00000381224,p.H501fs|uc001rja.3,p.H283fs|NM_175861,p.H439fs|ENST00000551659,p.H609fs|ENST00000539277,p.H547fs	retained_intron, protein_coding, processed_transcript	uc021qwi.1	frameshift deletion	exon10	c.1640_1649del	p.H547fs	MYYQRALQLHPQHNRALFNLGNLLK	MYYQRALQLHPQLFSIWGISSSPRRKRKKLSPY	4.0	7.0	-	-	4252_12:29709817-29709826 GCCCGGTTAT>-_MYYQRALQLHPQLFSIWGISSSPRRKRKKLSPY	0.0
8:125570991-125570991 G>A	0.0	4275	COLORECTAL	-	-	-	-	MTSS1	uc003yrj.2,p.S373L|uc011lin.1,p.S107L|ENST00000378017,p.S373L|NM_001282974,p.S373L|ENST00000395508,p.S107L	retained_intron, protein_coding, processed_transcript	uc011lin.1	nonsynonymous SNV	exon3	c.C320T	p.S107L	SVSECSSPTSVSSGSTMGAWVSTEK	SVSECSSPTSVSLGSTMGAWVSTEK	9.0	8.0	-	-	4275_8:125570991-125570991 G>A_SVSECSSPTSVSLGSTMGAWVSTEK	0.0
2:206592669-206592669 T>C	0.0	4317	COLORECTAL	-	-	-	-	NRP2	ENST00000412873,p.S349P|ENST00000540841,p.S349P|uc002vav.3,p.S349P|ENST00000360409,p.S349P|NM_003872,p.S349P|ENST00000540178,p.S349P|NM_018534,p.S349P|uc010fud.3,p.S349P|ENST00000357785,p.S349P|uc002vay.3,p.S349P|uc002vax.3,p.S349P|NM_201266,p.S349P|ENST00000272849,p.S349P|NM_201279,p.S349P|ENST00000357118,p.S349P|NM_201264,p.S349P|ENST00000417189,p.S349P|NM_201267,p.S349P|uc002vau.3,p.S349P|uc002vaw.3,p.S349P|ENST00000355117,p.S349P|uc002vat.3,p.S349P	retained_intron, protein_coding, processed_transcript	uc010fud.3	nonsynonymous SNV	exon8	c.T1045C	p.S349P	TMLTAIATQGAISRETQNGYYVKSY	TMLTAIATQGAIPRETQNGYYVKSY	7.0	7.0	-	-	4317_2:206592669-206592669 T>C_TMLTAIATQGAIPRETQNGYYVKSY	0.0
1:173776589-173776589 G>A	1.0	3713	MELANOMA	-	-	-	-	CENPL	NM_033319,p.P79L|ENST00000345664,p.P79L|ENST00000356198,p.P79L|NM_001127181,p.P79L|NM_001171182,p.P79L|uc001gje.4,p.P79L|ENST00000367710,p.P79L|uc001gjg.4,p.P79L|uc001gjf.4,p.P79L	protein_coding, processed_transcript	uc001gjg.4	nonsynonymous SNV	exon4	c.C236T	p.P79L	LLHKQWTLYSLTPLYKFSYSNLKEY	LLHKQWTLYSLTLLYKFSYSNLKEY	5.0	8.0	CD8	-	3713_1:173776589-173776589 G>A_LLHKQWTLYSLTLLYKFSYSNLKEY	1.0
11:65838313-65838313 G>A	1.0	3678	MELANOMA	-	-	-	-	PACS1	NM_018026,p.R119K|uc001ogz.1,p.R119K|uc001oha.2,p.R119K|ENST00000320580,p.R119K	retained_intron, protein_coding, nonsense_mediated_decay	uc001oha.2	nonsynonymous SNV	exon1	c.G356A	p.R119K	WEVDRSSSSCVPRLFSLTLKKLVML	WEVDRSSSSCVPKLFSLTLKKLVML	9.0	5.0	-	-	3678_11:65838313-65838313 G>A_WEVDRSSSSCVPKLFSLTLKKLVML	0.0
1:168260616-168260616 C>T	1.0	3903	MELANOMA	-	-	-	-	TBX19	ENST00000367821,p.S141F|NM_005149,p.S141F|uc001gfl.3,p.S141F|uc001gfj.4,p.S72F	protein_coding, processed_transcript	uc001gfl.3	nonsynonymous SNV	exon2	c.C422T	p.S141F	PNFGAHWMKAPISFSKVKLTNKLNG	PNFGAHWMKAPIFFSKVKLTNKLNG	5.0	10.0	-	-	3903_1:168260616-168260616 C>T_PNFGAHWMKAPIFFSKVKLTNKLNG	0.0
3:101136519-101136519 A>C	1.0	4320	COLORECTAL	-	-	-	-	SENP7	uc003duv.3,p.S101A|NM_001282802,p.S101A|ENST00000348610,p.S101A|uc003dut.3,p.S134A|uc003duu.3,p.S134A|ENST00000394094,p.S134A|NM_020654,p.S134A|ENST00000394095,p.S134A|NM_001282804,p.S101A|NM_001077203,p.S134A	retained_intron, protein_coding	uc003duv.3	nonsynonymous SNV	exon4	c.T301G	p.S101A	ANLCDANKVQSDSLPSTSVDSLETC	ANLCDANKVQSDALPSTSVDSLETC	6.0	2.0	-	-	4320_3:101136519-101136519 A>C_ANLCDANKVQSDALPSTSVDSLETC	0.0
11:114168841-114168841 C>T	1.0	3466	MELANOMA	-	-	-	-	NNMT	ENST00000299964,p.S108F|ENST00000535401,p.S108F|NM_006169,p.S108F|uc001pos.1,p.S108F|uc001por.1,p.S108F	retained_intron, protein_coding, processed_transcript	uc001pos.1	nonsynonymous SNV	exon2	c.C323T	p.S108F	KWLKKEPEAFDWSPVVTYVCDLEGN	KWLKKEPEAFDWFPVVTYVCDLEGN	10.0	6.0	-	-	3466_11:114168841-114168841 C>T_KWLKKEPEAFDWFPVVTYVCDLEGN	0.0
6:35212510-35212510 C>T	1.0	4259	COLORECTAL	-	-	-	-	SCUBE3	uc003okh.1,p.R662C|uc003okf.1,p.R775C|uc003okg.1,p.R774C|NM_152753,p.R775C|ENST00000274938,p.R775C|ENST00000394681,p.R791C	protein_coding	uc003okh.1	nonsynonymous SNV	exon18	c.C1984T	p.R662C	IRCAMGSYQPDFRQNFCSRCPGNTS	IRCAMGSYQPDFCQNFCSRCPGNTS	5.0	10.0	-	-	4259_6:35212510-35212510 C>T_IRCAMGSYQPDFCQNFCSRCPGNTS	0.0
22:26177754-26177754 C>A	0.0	3795	MELANOMA	-	-	-	-	MYO18B	uc010guz.1,p.N636K|uc010guy.1,p.N636K|ENST00000539302,p.N755K|ENST00000335473,p.N755K|NM_032608,p.N755K|ENST00000536101,p.N755K|uc003abz.1,p.N755K|ENST00000407587,p.N755K|uc011akb.1,p.N268K|uc003aca.1,p.N636K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011akb.1	nonsynonymous SNV	exon6	c.C804A	p.N268K	KSRVARQPEGESNFLVFSQMLAGLD	KSRVARQPEGESKFLVFSQMLAGLD	2.0	1.0	-	-	3795_22:26177754-26177754 C>A_KSRVARQPEGESKFLVFSQMLAGLD	0.0
19:18233540-18233540 C>G	1.0	4335	COLORECTAL	-	-	-	-	MAST3	NM_015016,p.N97K|ENST00000262811,p.N97K|uc002nhz.4,p.N97K	retained_intron, protein_coding	uc002nhz.4	nonsynonymous SNV	exon5	c.C291G	p.N97K	SLASLPSSGYGTNTPSSTLSSSSSS	SLASLPSSGYGTKTPSSTLSSSSSS	7.0	7.0	-	-	4335_19:18233540-18233540 C>G_SLASLPSSGYGTKTPSSTLSSSSSS	0.0
4:146560334-146560334 G>A	0.0	4345	COLORECTAL	-	-	ID=COSM367366;OCCURENCE=1(lung)	-	MMAA	ENST00000511969,p.G15S|NM_172250,p.G15S|ENST00000281317,p.G15S|uc003ikh.4,p.G15S	retained_intron, protein_coding, nonsense_mediated_decay	uc003ikh.4	nonsynonymous SNV	exon2	c.G43A	p.G15S	MLLPHPHQHFLKGLLRAPFRCYHFI	MLLPHPHQHFLKSLLRAPFRCYHFI	6.0	8.0	-	-	4345_4:146560334-146560334 G>A_MLLPHPHQHFLKSLLRAPFRCYHFI	0.0
9:37707498-37707498 G>T	0.0	4046	OVARIAN	-	-	-	-	FRMPD1	uc004aah.1,p.D63Y|ENST00000377765,p.D63Y|NM_014907,p.D63Y|uc004aag.1,p.D63Y|ENST00000539465,p.D63Y	protein_coding	uc004aah.1	nonsynonymous SNV	exon3	c.G187T	p.D63Y	LIPVRHTVKIDKDTLLQDYGFHISE	LIPVRHTVKIDKYTLLQDYGFHISE	4.0	4.0	-	-	4046_9:37707498-37707498 G>T_LIPVRHTVKIDKYTLLQDYGFHISE	0.0
16:223483-223483 T>C	0.0	4346	COLORECTAL	-	-	-	-	HBA2	ENST00000397806,p.C73R|ENST00000251595,p.C105R|NM_000517,p.C105R|uc002cfv.4,p.C105R	retained_intron, protein_coding	uc002cfv.4	nonsynonymous SNV	exon3	c.T313C	p.C105R	RVDPVNFKLLSHCLLVTLAAHLPAE	RVDPVNFKLLSHRLLVTLAAHLPAE	10.0	5.0	-	-	4346_16:223483-223483 T>C_RVDPVNFKLLSHRLLVTLAAHLPAE	0.0
19:14269259-14269259 C>T	1.0	3879	MELANOMA	-	-	-	-	LPHN1	ENST00000361434,p.G752E|uc010xno.2,p.G752E|ENST00000340736,p.G757E|uc010xnn.2,p.G757E|NM_014921,p.G752E|NM_001008701,p.G757E	retained_intron, protein_coding, processed_transcript	uc010xno.2	nonsynonymous SNV	exon12	c.G2255A	p.G752E	VKLAGEAGPGGPGGASLVVNSQVIA	VKLAGEAGPGGPEGASLVVNSQVIA	5.0	5.0	-	-	3879_19:14269259-14269259 C>T_VKLAGEAGPGGPEGASLVVNSQVIA	0.0
3:184100451-184100451 G>A	0.0	4037	NSCLC	-	-	-	-	CHRD	ENST00000204604,p.G291S|ENST00000348986,p.G291S|NM_003741,p.G291S|uc003fov.3,p.G291S|ENST00000420973,p.G291S|uc003fox.3,p.G291S|ENST00000450923,p.G291S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003fox.3	nonsynonymous SNV	exon8	c.G871A	p.G291S	AAETFSAILTLEGPPQQGVGGITLL	AAETFSAILTLESPPQQGVGGITLL	5.0	10.0	-	-	4037_3:184100451-184100451 G>A_AAETFSAILTLESPPQQGVGGITLL	0.0
3:124732616-124732616 G>A	1.0	2369	MELANOMA	-	-	-	-	HEG1	uc003ehs.4,p.H603Y|uc011bke.2,p.H703Y|NM_020733,p.H603Y|ENST00000311127,p.H603Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bke.2	nonsynonymous SNV	exon7	c.C2107T	p.H703Y	SNSSHSEYSSFFHAQTERSNISSYD	SNSSHSEYSSFFYAQTERSNISSYD	6.0	6.0	-	-	2369_3:124732616-124732616 G>A_SNSSHSEYSSFFYAQTERSNISSYD	0.0
17:44064433-44064433 G>A	1.0	3903	MELANOMA	-	-	-	-	MAPT	ENST00000415613,p.G385E|NM_001123066,p.G385E|ENST00000262410,p.G385E|uc010dau.3,p.G385E|NM_016835,p.G385E|ENST00000344290,p.G385E|ENST00000571987,p.G385E|uc002ijr.4,p.G385E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dau.3	nonsynonymous SNV	exon7	c.G1154A	p.G385E	QLKARMVSKSKDGTGSDDKKAKTST	QLKARMVSKSKDETGSDDKKAKTST	6.0	4.0	-	-	3903_17:44064433-44064433 G>A_QLKARMVSKSKDETGSDDKKAKTST	0.0
X:32381009-32381009 A>C	0.0	4317	COLORECTAL	-	-	-	-	DMD	uc004dda.1,p.L1741V|NM_004009,p.L1737V|uc004ddb.1,p.L1733V|NM_004012,p.L397V|uc004dcx.2,p.L400V|ENST00000357033,p.L1741V|uc004dcw.2,p.L397V|NM_004011,p.L400V|NM_000109,p.L1733V|NM_004006,p.L1741V|ENST00000378677,p.L1737V|uc004dcy.1,p.L1737V|NM_004010,p.L1618V|uc004dcz.2,p.L1618V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004ddb.1	nonsynonymous SNV	exon37	c.T5197G	p.L1733V	PKVDSTRDQAANLMANRGDHCRKLV	PKVDSTRDQAANVMANRGDHCRKLV	6.0	3.0	-	-	4317_X:32381009-32381009 A>C_PKVDSTRDQAANVMANRGDHCRKLV	0.0
5:64766720-64766720 C>A	0.0	2591	MELANOMA	-	-	-	-	ADAMTS6	ENST00000464680,p.W116L|uc003jtp.3,p.W116L|NM_197941,p.W116L|ENST00000381052,p.W116L|ENST00000536360,p.W116L|ENST00000381055,p.W116L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jtp.3	nonsynonymous SNV	exon3	c.G347T	p.W116L	TDFVSKHFTVEYWGKDGPQWKHDFL	TDFVSKHFTVEYLGKDGPQWKHDFL	1.0	5.0	-	-	2591_5:64766720-64766720 C>A_TDFVSKHFTVEYLGKDGPQWKHDFL	0.0
10:51464832-51464832 G>A	0.0	4081	COLORECTAL	-	-	ID=COSM117574;OCCURENCE=1(ovary)	-	AGAP7P	uc001jio.4,p.R542W|NM_001077685,p.R542W|ENST00000374095,p.R542W	protein_coding	uc001jio.4	nonsynonymous SNV	exon7	c.C1624T	p.R542W	KPTEKSTREEKERWIRSKYEEKLFL	KPTEKSTREEKEWWIRSKYEEKLFL	5.0	8.0	-	-	4081_10:51464832-51464832 G>A_KPTEKSTREEKEWWIRSKYEEKLFL	0.0
17:40940365-40940365 G>A	1.0	3713	MELANOMA	-	-	-	-	WNK4	uc002ibk.1,p.M432I|NM_032387,p.M660I|uc002ibj.3,p.M660I|ENST00000246914,p.M660I|uc010wgx.2,p.M324I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wgx.2	nonsynonymous SNV	exon9	c.G972A	p.M324I	SGLSDVGEGMGQMRRPPGRNLRRRP	SGLSDVGEGMGQIRRPPGRNLRRRP	7.0	10.0	-	-	3713_17:40940365-40940365 G>A_SGLSDVGEGMGQIRRPPGRNLRRRP	0.0
19:44933212-44933212 G>A	0.0	2556	MELANOMA	0.0018	-	-	-	ZNF229	ENST00000291187,p.R576W|ENST00000588931,p.R582W|uc010ejk.1,p.R236W|uc002oze.1,p.R582W|uc010ejl.1,p.R576W|NM_014518,p.R582W|NM_001278510,p.R576W	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ejl.1	nonsynonymous SNV	exon6	c.C1726T	p.R576W	KPYKCSECGKGFRRNSDLHSHQRVH	KPYKCSECGKGFWRNSDLHSHQRVH	5.0	4.0	-	-	2556_19:44933212-44933212 G>A_KPYKCSECGKGFWRNSDLHSHQRVH	0.0
1:237875123-237875123 T>G	0.0	4326	BREAST	-	-	-	-	RYR2	NM_001035,p.S3437A|uc010pxz.1,p.S392A|ENST00000366574,p.S3437A|ENST00000542537,p.S3421A|ENST00000360064,p.S3435A|uc001hyl.1,p.S3437A	protein_coding, processed_transcript	uc010pxz.1	nonsynonymous SNV	exon10	c.T1174G	p.S392A	INNMSFLITDTKSKMSKAAVSDQER	INNMSFLITDTKAKMSKAAVSDQER	3.0	5.0	-	-	4326_1:237875123-237875123 T>G_INNMSFLITDTKAKMSKAAVSDQER	0.0
1:152281771-152281771 A>C	0.0	4186	BREAST	-	-	-	-	FLG	ENST00000368799,p.V1864G|uc001ezu.1,p.V1864G|NM_002016,p.V1864G	protein_coding	uc001ezu.1	nonsynonymous SNV	exon3	c.T5591G	p.V1864G	SDVSRGQSGSRSVSRQTRNEKQSGD	SDVSRGQSGSRSGSRQTRNEKQSGD	1.0	3.0	-	-	4186_1:152281771-152281771 A>C_SDVSRGQSGSRSGSRQTRNEKQSGD	0.0
19:13186456-13186456 C>T	1.0	4081	COLORECTAL	-	-	-	-	NFIX	uc010xmx.2,p.S317F|NM_002501,p.S309F|uc002mwg.2,p.S308F|uc002mwe.4,p.S301F|ENST00000397661,p.S309F|ENST00000588228,p.S262F|uc002mwd.3,p.S309F|NM_001271043,p.S317F|ENST00000587760,p.S301F|ENST00000585575,p.S301F|NM_001271044,p.S301F|ENST00000592199,p.S309F|ENST00000587260,p.S308F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010xmx.2	nonsynonymous SNV	exon6	c.C950T	p.S317F	GTGRSPAAGSSQSSGWPNDVDAGPA	GTGRSPAAGSSQFSGWPNDVDAGPA	10.0	7.0	-	-	4081_19:13186456-13186456 C>T_GTGRSPAAGSSQFSGWPNDVDAGPA	0.0
13:46705031-46705031 C>T	1.0	4275	COLORECTAL	-	-	ID=COSM1367071;OCCURENCE=1(large_intestine)	2	LCP1	NM_002298,p.D557N|uc010ack.3,p.D126N|uc001vaz.4,p.D557N|ENST00000323076,p.D557N|uc001vba.4,p.D557N|uc001vay.4,p.D154N|ENST00000398576,p.D557N|ENST00000435666,p.D126N	protein_coding, processed_transcript	uc010ack.3	nonsynonymous SNV	exon4	c.G376A	p.D126N	KISTSLPVLDLIDAIQPGSINYDLL	KISTSLPVLDLINAIQPGSINYDLL	10.0	3.0	-	-	4275_13:46705031-46705031 C>T_KISTSLPVLDLINAIQPGSINYDLL	0.0
3:100065086-100065086 C>G	1.0	4244	COLORECTAL	-	-	-	-	NIT2	uc011bha.1,p.S133C	retained_intron, protein_coding, nonsense_mediated_decay	uc011bha.1	nonsynonymous SNV	exon5	c.C398G	p.S133C	SATTCGLQSLHKSTHREAASCWYIQ	SATTCGLQSLHKCTHREAASCWYIQ	10.0	4.0	-	-	4244_3:100065086-100065086 C>G_SATTCGLQSLHKCTHREAASCWYIQ	0.0
10:62631290-62631290 G>A	1.0	3713	MELANOMA	-	-	ID=COSM919334;OCCURENCE=1(endometrium)	-	RHOBTB1	uc001jli.3,p.R681C|NM_014836,p.R681C|uc001jlk.3,p.R681C|ENST00000337910,p.R681C|uc001jlh.3,p.R681C|uc001jlj.3,p.R681C|ENST00000357917,p.R681C|NM_001242359,p.R681C|uc009xpe.2,p.R619C	protein_coding, processed_transcript	uc009xpe.2	nonsynonymous SNV	exon9	c.C1855T	p.R619C	EREKEDIALNKHRSRRKWCFWNSSP	EREKEDIALNKHCSRRKWCFWNSSP	5.0	6.0	-	-	3713_10:62631290-62631290 G>A_EREKEDIALNKHCSRRKWCFWNSSP	0.0
21:37742103-37742103 G>T	1.0	3678	MELANOMA	-	-	-	-	MORC3	ENST00000551788,p.A65S|ENST00000549948,p.A65S|uc002yvi.3,p.A813S|ENST00000400485,p.A813S|ENST00000546482,p.A65S|NM_015358,p.A813S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002yvi.3	nonsynonymous SNV	exon15	c.G2437T	p.A813S	SNNESKSEMDEMAVQLDDVFRQLDK	SNNESKSEMDEMSVQLDDVFRQLDK	10.0	8.0	-	-	3678_21:37742103-37742103 G>T_SNNESKSEMDEMSVQLDDVFRQLDK	0.0
3:112289455-112289455 C>T	1.0	3466	MELANOMA	-	-	-	-	SLC35A5	ENST00000261034,p.P100S|ENST00000492406,p.P100S|uc003dze.4,p.P100S|ENST00000484995,p.P100S|NM_017945,p.P100S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003dze.4	nonsynonymous SNV	exon4	c.C298T	p.P100S	WKEFSDFMKWSIPAFLYFLDNLIVF	WKEFSDFMKWSISAFLYFLDNLIVF	9.0	4.0	-	-	3466_3:112289455-112289455 C>T_WKEFSDFMKWSISAFLYFLDNLIVF	0.0
13:41328211-41328211 C>A	1.0	4126	NSCLC	-	-	-	-	MRPS31	uc001uxm.4,p.G253V|ENST00000323563,p.G253V|NM_005830,p.G253V	protein_coding, processed_transcript	uc001uxm.4	nonsynonymous SNV	exon5	c.G758T	p.G253V	TDDLKKRKNIFTGKRLNIFDMMAVT	TDDLKKRKNIFTVKRLNIFDMMAVT	6.0	1.0	-	-	4126_13:41328211-41328211 C>A_TDDLKKRKNIFTVKRLNIFDMMAVT	0.0
11:73809133-73809133 T>C	0.0	4245	COLORECTAL	-	-	-	-	C2CD3	NM_015531,p.N967S|NM_001286577,p.N967S|uc001ouu.2,p.N967S|ENST00000313663,p.N967S|ENST00000334126,p.N967S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ouu.2	nonsynonymous SNV	exon16	c.A2900G	p.N967S	SSNQIMALQRLKNEEGTLPPFSPRP	SSNQIMALQRLKSEEGTLPPFSPRP	7.0	10.0	-	-	4245_11:73809133-73809133 T>C_SSNQIMALQRLKSEEGTLPPFSPRP	0.0
2:61275891-61275891 A>G	1.0	4244	COLORECTAL	-	-	-	-	PEX13	uc002sau.4,p.K400E|ENST00000295030,p.K400E|NM_002618,p.K400E	protein_coding, processed_transcript	uc002sau.4	nonsynonymous SNV	exon4	c.A1198G	p.K400E	PVAPDSIGKDGEKQDL	PVAPDSIGKDGEEQDL	8.0	8.0	-	-	4244_2:61275891-61275891 A>G_PVAPDSIGKDGEEQDL	0.0
5:140208253-140208253 G>A	1.0	3903	MELANOMA	-	-	-	-	PCDHA6	ENST00000527624,p.G193R|uc003lho.2,p.G193R|NM_031848,p.G193R|uc011dab.2,p.G193R|NM_031849,p.G193R|NM_018909,p.G193R|ENST00000529310,p.G193R|uc003lhn.2,p.G193R	protein_coding	uc011dab.2	nonsynonymous SNV	exon1	c.G577A	p.G193R	DVKINSDDNKQIGLLLKKSLDREEA	DVKINSDDNKQIRLLLKKSLDREEA	4.0	5.0	-	-	3903_5:140208253-140208253 G>A_DVKINSDDNKQIRLLLKKSLDREEA	0.0
17:73997571-73997571 A>C	0.0	4320	COLORECTAL	-	-	-	-	CDK3	uc010dgt.3,p.K22T|ENST00000425876,p.K22T|ENST00000448471,p.K22T|NM_001258,p.K22T|ENST00000588812,p.K22T	protein_coding	uc010dgt.3	nonsynonymous SNV	exon2	c.A65C	p.K22T	IGEGTYGVVYKAKNRETGQLVALKK	IGEGTYGVVYKATNRETGQLVALKK	6.0	1.0	-	-	4320_17:73997571-73997571 A>C_IGEGTYGVVYKATNRETGQLVALKK	0.0
7:43490462-43490462 A>C	0.0	4245	COLORECTAL	-	-	-	-	HECW1	NM_015052,p.S812R|uc003tid.1,p.S812R|ENST00000395891,p.S812R	protein_coding, processed_transcript	uc003tid.1	nonsynonymous SNV	exon12	c.A2434C	p.S812R	GECPILHNSQPVSQLPSLRPEHHHY	GECPILHNSQPVRQLPSLRPEHHHY	3.0	1.0	-	-	4245_7:43490462-43490462 A>C_GECPILHNSQPVRQLPSLRPEHHHY	0.0
X:86071073-86071073 G>A	0.0	3903	MELANOMA	-	-	-	-	DACH2	uc010nmr.2,p.G355E|uc010nmq.2,p.G440E|uc004eew.2,p.G574E|uc011mra.1,p.G407E|NM_001139515,p.G407E|NM_053281,p.G574E|ENST00000508860,p.G407E|ENST00000373125,p.G574E|ENST00000510272,p.G355E	protein_coding, processed_transcript, nonsense_mediated_decay	uc011mra.1	nonsynonymous SNV	exon11	c.G1220A	p.G407E	DTGIPDIEIENNGTPHDSAAMQGGN	DTGIPDIEIENNETPHDSAAMQGGN	1.0	10.0	-	-	3903_X:86071073-86071073 G>A_DTGIPDIEIENNETPHDSAAMQGGN	0.0
3:194790460-194790460 G>A	1.0	3678	MELANOMA	-	-	-	-	XXYLT1	uc003ful.3,p.P186L|NM_152531,p.P389L|ENST00000429994,p.P243L|ENST00000355729,p.P186L|ENST00000356740,p.P183L|uc003fum.4,p.P389L|ENST00000310380,p.P389L|uc003fuk.3,p.P183L|ENST00000437101,p.P186L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fum.4	nonsynonymous SNV	exon4	c.C1166T	p.P389L	GHVKIYHGNCNTPIPED	GHVKIYHGNCNTLIPED	5.0	3.0	-	-	3678_3:194790460-194790460 G>A_GHVKIYHGNCNTLIPED	0.0
11:62400140-62400140 G>A	1.0	3879	MELANOMA	-	-	-	-	GANAB	ENST00000540933,p.S201F|ENST00000346178,p.S320F|uc001nuc.4,p.S201F|uc010rmb.3,p.S184F|NM_198334,p.S298F|ENST00000356638,p.S298F|NM_198335,p.S320F|NM_001278192,p.S206F|NM_001278193,p.S184F|uc001nua.4,p.S320F|uc001nub.4,p.S298F|NM_001278194,p.S201F|uc010rma.3,p.S206F|ENST00000534779,p.S206F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rmb.3	nonsynonymous SNV	exon6	c.C551T	p.S184F	QYELYNPMALYGSVPVLLAHNPHRD	QYELYNPMALYGFVPVLLAHNPHRD	10.0	5.0	CD8	-	3879_11:62400140-62400140 G>A_QYELYNPMALYGFVPVLLAHNPHRD	1.0
5:141694402-141694402 G>A	1.0	2556	MELANOMA	-	-	-	-	SPRY4	ENST00000434127,p.S91F|NM_001127496,p.S91F|uc003lml.2,p.S91F|uc010jgi.1,p.S114F|uc021yet.1,p.S91F|ENST00000344120,p.S114F|NM_001293290,p.S91F|NM_030964,p.S114F|NM_001293289,p.S91F	protein_coding, processed_transcript	uc021yet.1	nonsynonymous SNV	exon1	c.C272T	p.S91F	ARCDQDVTHHWISFSGRPSSVSSSS	ARCDQDVTHHWIFFSGRPSSVSSSS	10.0	7.0	-	-	2556_5:141694402-141694402 G>A_ARCDQDVTHHWIFFSGRPSSVSSSS	0.0
17:48192989-48192989 G>T	1.0	3903	MELANOMA	-	-	-	-	SAMD14	uc002iqg.4,p.T254N|uc002iqe.4,p.T37N|ENST00000330175,p.T254N|ENST00000285206,p.T266N|NM_001257359,p.T254N|uc002iqf.4,p.T254N|ENST00000503131,p.T254N|NM_174920,p.T254N	retained_intron, protein_coding, processed_transcript	uc002iqg.4	nonsynonymous SNV	exon7	c.C761A	p.T254N	TDSGKGSASSGSTTSPTCSPKHEGF	TDSGKGSASSGSNTSPTCSPKHEGF	5.0	5.0	-	-	3903_17:48192989-48192989 G>T_TDSGKGSASSGSNTSPTCSPKHEGF	0.0
9:32542310-32542310 T>G	1.0	3678	MELANOMA	-	-	-	-	TOPORS	NM_005802,p.E738A|NM_001195622,p.E673A|uc003zrc.3,p.E673A|uc003zrb.3,p.E738A|ENST00000360538,p.E738A|ENST00000379858,p.E673A	protein_coding	uc003zrc.3	nonsynonymous SNV	exon2	c.A2018C	p.E673A	SRAHYSRQSSSPEFRVQSFSERTNA	SRAHYSRQSSSPAFRVQSFSERTNA	7.0	10.0	-	-	3678_9:32542310-32542310 T>G_SRAHYSRQSSSPAFRVQSFSERTNA	0.0