Variant key	seen in RNA (1=Yes,0=No)	ID	tumor type	1000genome all freq	dbSNP_ID	Cosmic Info	CGC Tier	Gene Name	All Transcripts AAchange for 25mer	Transcript Info	transcript ID	Mutation type	Exon	cDNA change	AA change	Wt Epitope	Mut Epitope	Gene Expression Decile for this sample(1=lowest expression-10=highest expression)	Exome VAF Decile	Screening Status	Comments	key	mmp status
19:57089898-57089898 G>A	0.0	4186	BREAST	0.0005	-	-	-	ZNF470	ENST00000391709,p.G701R|NM_001001668,p.G701R|uc002qnl.4,p.G701R|ENST00000330619,p.G701R	protein_coding, processed_transcript	uc002qnl.4	nonsynonymous SNV	exon6	c.G2101A	p.G701R	SVHLAHHQRIHTGESSVILSSALPY	SVHLAHHQRIHTRESSVILSSALPY	3.0	5.0	-	-	4186_19:57089898-57089898 G>A_SVHLAHHQRIHTRESSVILSSALPY	0.0
4:87696678-87696678 G>A	0.0	4186	BREAST	-	-	-	1	PTPN13	NM_080683,p.E1922K|ENST00000427191,p.E1903K|ENST00000411767,p.E1922K|ENST00000436978,p.E1927K|uc003hqc.1,p.E288K|ENST00000511467,p.E1927K|NM_080684,p.E1731K|NM_080685,p.E1927K|NM_006264,p.E1903K|uc003hqb.3,p.E1731K|uc003hpz.3,p.E1922K|ENST00000316707,p.E1731K|uc003hpy.3,p.E1927K|uc003hqa.3,p.E1903K	retained_intron, protein_coding	uc003hqc.1	nonsynonymous SNV	exon7	c.G862A	p.E288K	ISDINPRSVAAIEGNLQLLDVIHYV	ISDINPRSVAAIKGNLQLLDVIHYV	4.0	7.0	-	-	4186_4:87696678-87696678 G>A_ISDINPRSVAAIKGNLQLLDVIHYV	0.0
13:35923297-35923297 G>C	1.0	4234	NSCLC	-	-	-	2	NBEA	NM_015678,p.E1986Q|ENST00000310336,p.E1986Q|ENST00000400445,p.E1986Q|uc010abi.3,p.E642Q|ENST00000379939,p.E1983Q|uc021rid.1,p.E1986Q|ENST00000540320,p.E1986Q	protein_coding, processed_transcript	uc021rid.1	nonsynonymous SNV	exon37	c.G5956C	p.E1986Q	MKDHIVRVANEAEFILNRQRAEDVH	MKDHIVRVANEAQFILNRQRAEDVH	5.0	9.0	-	-	4234_13:35923297-35923297 G>C_MKDHIVRVANEAQFILNRQRAEDVH	0.0
8:54859308-54859308 G>A	0.0	4235	COLORECTAL	-	-	-	-	RGS20	NM_001286673,p.S133N|NM_170587,p.S248N|NM_001286675,p.S40N|NM_003702,p.S101N|uc003xrp.3,p.S248N|uc003xrs.3,p.S101N|ENST00000297313,p.S248N|uc010lye.3,p.S40N|ENST00000276500,p.S101N|ENST00000344277,p.S133N|uc003xrq.3,p.S133N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010lye.3	nonsynonymous SNV	exon2	c.G119A	p.S40N	HELRADLPTWEESPAPTLEEVNAWA	HELRADLPTWEENPAPTLEEVNAWA	1.0	3.0	-	-	4235_8:54859308-54859308 G>A_HELRADLPTWEENPAPTLEEVNAWA	0.0
19:41930509-41930509 A>C	1.0	4345	COLORECTAL	-	-	-	-	BCKDHA	uc010xvz.2,p.K448T|uc002oqr.3,p.K444T|ENST00000457836,p.K448T|uc002oqm.4,p.K479T|NM_000709,p.K445T|uc002oqq.3,p.K445T|ENST00000540732,p.K479T|ENST00000595085,p.K479T|ENST00000269980,p.K445T|NM_001164783,p.K444T	retained_intron, protein_coding, processed_transcript	uc010xvz.2	nonsynonymous SNV	exon9	c.A1343C	p.K448T	TYGEHYPLDHFDK	TYGEHYPLDHFDT	9.0	4.0	-	-	4345_19:41930509-41930509 A>C_TYGEHYPLDHFDT	0.0
2:233409212-233409212 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	CHRNG	ENST00000389492,p.L339F|ENST00000389494,p.L391F|NM_005199,p.L391F|uc010fye.1,p.L339F|uc002vsx.1,p.L391F	retained_intron, protein_coding	uc010fye.1	nonsynonymous SNV	exon9	c.C1015T	p.L339F	SGWSITTGEEVALCLPRSELLFQQW	SGWSITTGEEVAFCLPRSELLFQQW	4.0	5.0	-	-	4258_2:233409212-233409212 C>T_SGWSITTGEEVAFCLPRSELLFQQW	0.0
5:112164603-112164603 ->A	1.0	4245	COLORECTAL	-	-	-	1	APC	uc003kpz.4,p.S559fs|uc011cvt.2,p.S541fs|NM_001127511,p.S541fs|ENST00000507379,p.S541fs|NM_000038,p.S559fs|ENST00000257430,p.S559fs|NM_001127510,p.S559fs|uc003kpy.4,p.S559fs|uc010jbz.3,p.S276fs|ENST00000508376,p.S559fs|ENST00000457016,p.S559fs|ENST00000512211,p.S559fs|ENST00000504915,p.S122fs	 nonsense_mediated_decay,retained_intron, protein_coding, processed_transcript	uc011cvt.2	frameshift insertion	exon12	c.1624dupA	p.S541fs	VLRNLSWRADVNSKKTLREVGSVKA	VLRNLSWRADVNSKKDVARSWKCESIDGMCFRS	6.0	9.0	-	-	4245_5:112164603-112164603 ->A_VLRNLSWRADVNSKKDVARSWKCESIDGMCFRS	0.0
12:25054798-25054798 C>T	0.0	4235	COLORECTAL	-	-	-	-	BCAT1	ENST00000538118,p.A9T|NM_001178094,p.A9T|uc001rgc.3,p.A9T	protein_coding, processed_transcript	uc001rgc.3	nonsynonymous SNV	exon2	c.G25A	p.A9T	MDCSNGCSAECTGEGGSKEVV	MDCSNGCSTECTGEGGSKEVV	5.0	8.0	-	-	4235_12:25054798-25054798 C>T_MDCSNGCSTECTGEGGSKEVV	0.0
1:168511244-168511244 A>T	0.0	4046	OVARIAN	-	-	-	-	XCL2	ENST00000367819,p.L55M|NM_003175,p.L55M|uc001gfn.4,p.L55M	protein_coding	uc001gfn.4	nonsynonymous SNV	exon2	c.T163A	p.L55M	SRIKTYTITEGSLRAVIFITKRGLK	SRIKTYTITEGSMRAVIFITKRGLK	3.0	4.0	-	-	4046_1:168511244-168511244 A>T_SRIKTYTITEGSMRAVIFITKRGLK	0.0
14:23311710-23311710 C>T	1.0	4177	PANCREATIC	-	-	-	-	MMP14	ENST00000311852,p.R158C|uc001whc.3,p.R158C|NM_004995,p.R158C|ENST00000548761,p.R164C	retained_intron, protein_coding, processed_transcript	uc001whc.3	nonsynonymous SNV	exon4	c.C472T	p.R158C	KAFRVWESATPLRFREVPYAYIREG	KAFRVWESATPLCFREVPYAYIREG	10.0	10.0	CD8	-	4177_14:23311710-23311710 C>T_KAFRVWESATPLCFREVPYAYIREG	2.0
1:16525147-16525147 G>C	1.0	3713	MELANOMA	-	-	-	-	ARHGEF19	ENST00000270747,p.R782G|uc001ayc.1,p.R782G|NM_153213,p.R782G	protein_coding, processed_transcript	uc001ayc.1	nonsynonymous SNV	exon16	c.C2344G	p.R782G	YVEEISSLSARLRNLRENKRVTSAT	YVEEISSLSARLGNLRENKRVTSAT	3.0	9.0	-	-	3713_1:16525147-16525147 G>C_YVEEISSLSARLGNLRENKRVTSAT	0.0
19:35757614-35757614 C>T	1.0	4186	BREAST	-	-	-	-	LSR	ENST00000605618,p.R228W|NM_001260490,p.R269W|ENST00000427250,p.R221W|NM_205835,p.R309W|ENST00000354900,p.R358W|NM_015925,p.R358W|uc002nyn.3,p.R309W|ENST00000360798,p.R309W|NM_205834,p.R377W|uc002nym.3,p.R358W|uc002nyl.3,p.R377W|ENST00000361790,p.R377W|uc010xsr.2,p.R269W	retained_intron, protein_coding	uc010xsr.2	nonsynonymous SNV	exon4	c.C805T	p.R269W	SAGGQGSYVPLLRDTDSSVASEVRS	SAGGQGSYVPLLWDTDSSVASEVRS	10.0	8.0	CD8	-	4186_19:35757614-35757614 C>T_SAGGQGSYVPLLWDTDSSVASEVRS	1.0
16:68104875-68104875 C>T	1.0	2369	MELANOMA	-	-	-	-	DUS2	uc002evj.4,p.S225L|NM_017803,p.S225L|ENST00000432752,p.S190L|uc010vkk.3,p.S190L|uc002evi.4,p.S225L|ENST00000565263,p.S225L|ENST00000358896,p.S225L|NM_001271762,p.S225L|NM_001271763,p.S190L	retained_intron, protein_coding, nonsense_mediated_decay	uc010vkk.3	nonsynonymous SNV	exon10	c.C569T	p.S190L	ANGGSHDHIQQYSDIEDFRQATAAS	ANGGSHDHIQQYLDIEDFRQATAAS	6.0	3.0	-	-	2369_16:68104875-68104875 C>T_ANGGSHDHIQQYLDIEDFRQATAAS	0.0
1:235345320-235345320 C>T	1.0	3466	MELANOMA	-	-	-	-	ARID4B	uc021pks.1,p.V972M|uc001hwr.3,p.V886M|uc001hwt.4,p.V653M|NM_016374,p.V972M|uc001hws.4,p.V886M|ENST00000421364,p.V972M|NM_031371,p.V886M|ENST00000349213,p.V886M|NM_001206794,p.V972M|uc001hwq.3,p.V972M|ENST00000264183,p.V972M|ENST00000366603,p.V972M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pks.1	nonsynonymous SNV	exon20	c.G2914A	p.V972M	PEEGVAEESLQTVAEEESCSPSVEL	PEEGVAEESLQTMAEEESCSPSVEL	10.0	3.0	-	-	3466_1:235345320-235345320 C>T_PEEGVAEESLQTMAEEESCSPSVEL	0.0
2:73678780-73678780 C>T	0.0	4186	BREAST	-	-	-	-	ALMS1	ENST00000377715,p.S1708F|uc002sjh.1,p.S1096F|ENST00000264448,p.S1708F|uc002sjf.1,p.S1666F|uc002sjg.3,p.S1096F|ENST00000409009,p.S1666F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002sjh.1	nonsynonymous SNV	exon1	c.C3287T	p.S1096F	PDAQKTETPSVSSSLYSYREKPIVF	PDAQKTETPSVSFSLYSYREKPIVF	6.0	8.0	-	-	4186_2:73678780-73678780 C>T_PDAQKTETPSVSFSLYSYREKPIVF	0.0
3:113775283-113775283 A>C	1.0	4213	COLORECTAL	-	-	-	-	KIAA1407	uc003eax.3,p.S11A|ENST00000491000,p.S11A|NM_020817,p.S11A|ENST00000460813,p.S11A|ENST00000295878,p.S11A|ENST00000463695,p.S11A|uc011bip.1,p.S11A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bip.1	nonsynonymous SNV	exon1	c.T31G	p.S11A	MLLAPQGRSFSKKRMGLNRWKRF	MLLAPQGRSFAKKRMGLNRWKRF	7.0	4.0	-	-	4213_3:113775283-113775283 A>C_MLLAPQGRSFAKKRMGLNRWKRF	0.0
11:7111154-7111154 G>A	0.0	4245	COLORECTAL	-	-	ID=COSM1223403;OCCURENCE=1(large_intestine)	-	RBMXL2	ENST00000306904,p.R268H|NM_014469,p.R268H|uc001mfc.2,p.R268H	protein_coding	uc001mfc.2	nonsynonymous SNV	exon1	c.G803A	p.R268H	GYSDRDGYGGRDRDYGDHLSRGSHR	GYSDRDGYGGRDHDYGDHLSRGSHR	2.0	8.0	-	-	4245_11:7111154-7111154 G>A_GYSDRDGYGGRDHDYGDHLSRGSHR	0.0
7:4107534-4107534 G>T	0.0	4266	COLORECTAL	-	-	-	-	SDK1	NM_152744,p.W992C|uc010kso.3,p.W268C|ENST00000389531,p.W992C|uc003smx.3,p.W992C|ENST00000404826,p.W992C	retained_intron, protein_coding, processed_transcript	uc010kso.3	nonsynonymous SNV	exon6	c.G804T	p.W268C	FTEILDTSLKVSWQEPLEKNGIITG	FTEILDTSLKVSCQEPLEKNGIITG	5.0	4.0	-	-	4266_7:4107534-4107534 G>T_FTEILDTSLKVSCQEPLEKNGIITG	0.0
4:76720820-76720820 A>G	1.0	4189	MELANOMA	-	-	-	-	USO1	uc003hiv.3,p.T342A|ENST00000514213,p.T485A|ENST00000538159,p.T509A|uc003hiw.3,p.T335A	retained_intron, protein_coding	uc003hiw.3	nonsynonymous SNV	exon11	c.A1003G	p.T335A	IQTRVGLLMLLCTWLSNCPIAVTHF	IQTRVGLLMLLCAWLSNCPIAVTHF	10.0	4.0	-	-	4189_4:76720820-76720820 A>G_IQTRVGLLMLLCAWLSNCPIAVTHF	0.0
3:89390994-89390994 C>T	0.0	4316	COLORECTAL	-	-	-	2	EPHA3	uc003dqx.1,p.R354W|NM_182644,p.R354W|uc021xbf.1,p.R354W|NM_005233,p.R354W|uc003dqy.3,p.R354W|ENST00000494014,p.R354W|ENST00000452448,p.R354W|ENST00000336596,p.R354W	protein_coding	uc021xbf.1	nonsynonymous SNV	exon5	c.C1060T	p.R354W	ILDWSWPLDTGGRKDVTFNIICKKC	ILDWSWPLDTGGWKDVTFNIICKKC	2.0	7.0	-	-	4316_3:89390994-89390994 C>T_ILDWSWPLDTGGWKDVTFNIICKKC	0.0
8:119391895-119391895 C>T	0.0	3903	MELANOMA	-	-	-	-	SAMD12	ENST00000526328,p.G123R|NM_001101676,p.G123R|uc003yom.2,p.G123R|ENST00000314727,p.G123R|uc010mda.1,p.G123R|NM_207506,p.G123R|ENST00000409003,p.G123R|ENST00000524796,p.G115R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010mda.1	nonsynonymous SNV	exon4	c.G367A	p.G123R	LLRLTDKKLERMGIAQENLRQHILQ	LLRLTDKKLERMRIAQENLRQHILQ	1.0	9.0	-	-	3903_8:119391895-119391895 C>T_LLRLTDKKLERMRIAQENLRQHILQ	0.0
5:38876329-38876329 C>T	1.0	3466	MELANOMA	-	-	ID=COSM3393556;OCCURENCE=1(pancreas)	-	OSMR	uc003jln.2,p.P34S|NM_001168355,p.P34S|ENST00000502536,p.P34S|NM_003999,p.P34S|uc003jlm.2,p.P34S|ENST00000274276,p.P34S	protein_coding, nonsense_mediated_decay	uc003jln.2	nonsynonymous SNV	exon3	c.C100T	p.P34S	QSEVLAERLPLTPVSLKVSTNSTRQ	QSEVLAERLPLTSVSLKVSTNSTRQ	8.0	2.0	-	-	3466_5:38876329-38876329 C>T_QSEVLAERLPLTSVSLKVSTNSTRQ	0.0
7:136700514-136700514 T>A	0.0	3903	MELANOMA	-	-	-	-	CHRM2	uc003vtf.1,p.I301K|NM_001006627,p.I301K|ENST00000445907,p.I301K|NM_001006629,p.I301K|ENST00000401861,p.I301K|uc003vtm.1,p.I301K|uc003vtg.1,p.I301K|NM_001006630,p.I301K|NM_001006632,p.I301K|NM_001006626,p.I301K|uc022ame.1,p.I301K|ENST00000320658,p.I301K|uc003vtn.1,p.I301K|uc003vto.1,p.I301K|ENST00000453373,p.I301K|NM_001006628,p.I301K|ENST00000397608,p.I301K|uc003vti.1,p.I301K|NM_000739,p.I301K|uc003vtl.1,p.I301K|uc003vtk.1,p.I301K|NM_001006631,p.I301K|uc003vtj.1,p.I301K|ENST00000402486,p.I301K	protein_coding, processed_transcript	uc022ame.1	nonsynonymous SNV	exon1	c.T902A	p.I301K	VSAVASNMRDDEITQDENTVSTSLG	VSAVASNMRDDEKTQDENTVSTSLG	1.0	5.0	-	-	3903_7:136700514-136700514 T>A_VSAVASNMRDDEKTQDENTVSTSLG	0.0
X:140785632-140785632 G>A	0.0	4246	COLORECTAL	-	-	-	-	SPANXC,SPANXD	NM_022661,p.P95L|ENST00000370515,p.P95L|uc004fbq.3,p.P95L|NM_032417,p.P95L	protein_coding	uc004fbq.3	nonsynonymous SNV	exon2	c.C284T	p.P95L	EEEEFMEIMVEIPAK	EEEEFMEIMVEILAK	1.0	3.0	-	-	4246_X:140785632-140785632 G>A_EEEEFMEIMVEILAK	0.0
19:4793035-4793035 C>T	1.0	3466	MELANOMA	-	-	-	-	FEM1A	ENST00000269856,p.S390F|uc002mbf.3,p.S390F|NM_018708,p.S390F	protein_coding	uc002mbf.3	nonsynonymous SNV	exon1	c.C1169T	p.S390F	RERILGPSHPDTSYYIRYRGAVYAD	RERILGPSHPDTFYYIRYRGAVYAD	7.0	2.0	-	-	3466_19:4793035-4793035 C>T_RERILGPSHPDTFYYIRYRGAVYAD	0.0
13:76427283-76427283 C>T	1.0	2556	MELANOMA	-	-	-	-	LMO7	NM_005358,p.P1192S|ENST00000465261,p.P1241S|uc010thw.2,p.P1118S|NM_015842,p.P1241S|uc001vjv.3,p.P1241S|uc010thv.2,p.P1192S|ENST00000526202,p.P1118S|uc021rkq.1,p.P1474S|ENST00000377534,p.P1526S|ENST00000357063,p.P1526S|ENST00000341547,p.P1192S|ENST00000321797,p.P1241S	retained_intron, protein_coding, processed_transcript	uc021rkq.1	nonsynonymous SNV	exon28	c.C4420T	p.P1474S	LDSPRSNSWRQPPWLNQPTGFYASS	LDSPRSNSWRQPSWLNQPTGFYASS	10.0	7.0	-	-	2556_13:76427283-76427283 C>T_LDSPRSNSWRQPSWLNQPTGFYASS	0.0
3:122642525-122642525 C>T	0.0	4259	COLORECTAL	-	-	ID=COSM218739,COSM218740;OCCURENCE=2(pancreas)	-	SEMA5B	uc011bju.2,p.R346H|uc003egb.2,p.R404H|ENST00000357599,p.R404H|NM_001256346,p.R404H|ENST00000393583,p.R404H|uc010hro.2,p.R346H|uc003efz.2,p.R404H|NM_001256348,p.R346H|ENST00000451055,p.R458H|NM_001256347,p.R458H|NM_001031702,p.R404H|ENST00000475244,p.R404H|uc031sbm.1,p.R458H|ENST00000195173,p.R404H	protein_coding, processed_transcript, nonsense_mediated_decay	uc031sbm.1	nonsynonymous SNV	exon10	c.G1373A	p.R458H	LSAISQAFNGPFRYQENPRAAWLPI	LSAISQAFNGPFHYQENPRAAWLPI	5.0	10.0	-	-	4259_3:122642525-122642525 C>T_LSAISQAFNGPFHYQENPRAAWLPI	0.0
2:185803062-185803062 C>T	0.0	3903	MELANOMA	-	-	-	-	ZNF804A	uc002uph.3,p.P980L|ENST00000302277,p.P980L|NM_194250,p.P980L	protein_coding	uc002uph.3	nonsynonymous SNV	exon4	c.C2939T	p.P980L	SYLCHYELAEALPQGKMNETPTEWL	SYLCHYELAEALLQGKMNETPTEWL	2.0	3.0	-	-	3903_2:185803062-185803062 C>T_SYLCHYELAEALLQGKMNETPTEWL	0.0
1:114437968-114437968 G>A	1.0	3998	MELANOMA	-	-	ID=COSM1332828;OCCURENCE=1(large_intestine)	-	AP4B1	NM_001253853,p.P548S|ENST00000369567,p.P479S|ENST00000369569,p.P647S|ENST00000256658,p.P647S|uc010owp.2,p.P548S|NM_001253852,p.P647S|NM_006594,p.P647S|uc001eec.3,p.P479S|uc001eed.3,p.P647S|uc001eeb.3,p.P647S	protein_coding, processed_transcript	uc010owp.2	nonsynonymous SNV	exon11	c.C1642T	p.P548S	WLSLKVAHQQVLPWRGEFHPDTLQM	WLSLKVAHQQVLSWRGEFHPDTLQM	7.0	8.0	-	-	3998_1:114437968-114437968 G>A_WLSLKVAHQQVLSWRGEFHPDTLQM	0.0
2:179486277-179486277 C>T	1.0	4266	COLORECTAL	-	-	-	-	TTN	uc021vsy.2,p.A12524T|uc021vtb.2,p.A6027T|uc031rqc.1,p.A15092T|NM_001267550,p.A15092T|NM_133378,p.A12524T|ENST00000591111,p.A13451T|ENST00000359218,p.A6152T|uc031rqd.1,p.A13451T|ENST00000589042,p.A15092T|ENST00000460472,p.A6027T|NM_133437,p.A6219T|ENST00000342175,p.A6219T|uc021vsz.2,p.A6219T|uc021vta.2,p.A6152T|NM_133432,p.A6152T|NM_003319,p.A6027T|NM_001256850,p.A13451T|ENST00000342992,p.A12524T	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon195	c.G40351A	p.A13451T	TEGRKRILVIQNAHLEDAGNYNCRL	TEGRKRILVIQNTHLEDAGNYNCRL	5.0	8.0	-	-	4266_2:179486277-179486277 C>T_TEGRKRILVIQNTHLEDAGNYNCRL	0.0
3:194159638-194159638 G>A	1.0	3678	MELANOMA	0.0005	-	-	-	ATP13A3	ENST00000256031,p.R592C|uc003fty.4,p.R592C|ENST00000439040,p.R592C|uc003ftz.1,p.R298C|NM_024524,p.R592C	retained_intron, protein_coding	uc003ftz.1	nonsynonymous SNV	exon7	c.C892T	p.R298C	TALHNRIMPTVVRPPKQLLPESTPA	TALHNRIMPTVVCPPKQLLPESTPA	9.0	4.0	-	-	3678_3:194159638-194159638 G>A_TALHNRIMPTVVCPPKQLLPESTPA	0.0
13:103390563-103390563 T>C	0.0	4278	COLORECTAL	-	-	-	-	CCDC168	NM_001146197,p.I4162V|uc001vpm.3,p.I4162V	protein_coding	uc001vpm.3	nonsynonymous SNV	exon4	c.A12484G	p.I4162V	DYMQQKEDDEVKISAKKDIMHPEDK	DYMQQKEDDEVKVSAKKDIMHPEDK	5.0	8.0	-	-	4278_13:103390563-103390563 T>C_DYMQQKEDDEVKVSAKKDIMHPEDK	0.0
1:149761670-149761670 T>C	0.0	4320	COLORECTAL	-	-	-	-	FCGR1A	ENST00000444948,p.L115P|NM_000566,p.L207P|ENST00000369168,p.L207P|uc001esp.4,p.L207P	protein_coding, processed_transcript	uc001esp.4	nonsynonymous SNV	exon5	c.T620C	p.L207P	NASVTSPLLEGNLVTLSCETKLLLQ	NASVTSPLLEGNPVTLSCETKLLLQ	8.0	4.0	-	-	4320_1:149761670-149761670 T>C_NASVTSPLLEGNPVTLSCETKLLLQ	0.0
6:36938207-36938207 C>A	1.0	4237	NSCLC	-	-	-	-	MTCH1	ENST00000460219,p.D300Y|uc003onc.2,p.D316Y|ENST00000373627,p.D333Y|uc011dtt.3,p.D148Y|uc003one.5,p.D333Y|uc003ond.2,p.D333Y|ENST00000373616,p.D316Y|NM_014341,p.D316Y|NM_001271641,p.D333Y|ENST00000538808,p.D160Y	protein_coding, processed_transcript	uc011dtt.3	nonsynonymous SNV	exon9	c.G442T	p.D148Y	VSMLTYPFLLVGDLMAVNNCGLQAG	VSMLTYPFLLVGYLMAVNNCGLQAG	10.0	2.0	-	-	4237_6:36938207-36938207 C>A_VSMLTYPFLLVGYLMAVNNCGLQAG	0.0
17:33319646-33319646 G>A	1.0	3903	MELANOMA	-	-	-	-	LIG3	ENST00000262327,p.E464K|ENST00000585941,p.E473K|uc002hik.2,p.E464K|ENST00000378526,p.E464K|NM_002311,p.E464K|uc010cth.1,p.E473K|NM_013975,p.E464K|uc002hij.3,p.E464K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cth.1	nonsynonymous SNV	exon8	c.G1417A	p.E473K	ERVLHNAQEVEKEPGQRRALSVQAS	ERVLHNAQEVEKKPGQRRALSVQAS	8.0	2.0	-	-	3903_17:33319646-33319646 G>A_ERVLHNAQEVEKKPGQRRALSVQAS	0.0
11:9867113-9867113 G>A	1.0	3879	MELANOMA	-	-	ID=COSM933702;OCCURENCE=1(endometrium)	-	SBF2	uc001mib.2,p.R1037C|ENST00000256190,p.R1037C|NM_030962,p.R1037C|uc001mif.3,p.R793C	retained_intron, protein_coding, processed_transcript	uc001mif.3	nonsynonymous SNV	exon23	c.C2377T	p.R793C	ILPKQKEKNTSFRTFSKTIVKGAKR	ILPKQKEKNTSFCTFSKTIVKGAKR	7.0	9.0	-	-	3879_11:9867113-9867113 G>A_ILPKQKEKNTSFCTFSKTIVKGAKR	0.0
20:31756971-31756971 T>A	0.0	4245	COLORECTAL	-	-	-	-	BPIFA2	ENST00000253362,p.L7H|ENST00000354932,p.L7H|uc002wyo.1,p.L7H|NM_080574,p.L7H	protein_coding	uc002wyo.1	nonsynonymous SNV	exon2	c.T20A	p.L7H	MLQLWKLVLLCGVLTGTSE	MLQLWKHVLLCGVLTGTSE	3.0	2.0	-	-	4245_20:31756971-31756971 T>A_MLQLWKHVLLCGVLTGTSE	0.0
X:107979147-107979147 G>A	0.0	4266	COLORECTAL	-	-	-	1	IRS4	uc004eoc.2,p.P143L|ENST00000372129,p.P143L|NM_003604,p.P143L	protein_coding	uc004eoc.2	nonsynonymous SNV	exon1	c.C428T	p.P143L	AAASGAAIPPLIPPRRVITLYQCFS	AAASGAAIPPLILPRRVITLYQCFS	3.0	5.0	-	-	4266_X:107979147-107979147 G>A_AAASGAAIPPLILPRRVITLYQCFS	0.0
3:37493890-37493890 G>A	1.0	4317	COLORECTAL	-	-	-	-	ITGA9	ENST00000264741,p.G9S|uc003chd.3,p.G9S|ENST00000422441,p.G9S|uc003chc.3,p.G9S|NM_002207,p.G9S	retained_intron, protein_coding	uc003chd.3	nonsynonymous SNV	exon1	c.G25A	p.G9S	MGGPAAPRGAGRLRALLLALV	MGGPAAPRSAGRLRALLLALV	10.0	7.0	-	-	4317_3:37493890-37493890 G>A_MGGPAAPRSAGRLRALLLALV	0.0
X:54784940-54784940 G>A	0.0	4158	COLORECTAL	-	-	-	-	ITIH6	ENST00000218436,p.R523C|NM_198510,p.R523C|uc004dtj.2,p.R523C	protein_coding, processed_transcript	uc004dtj.2	nonsynonymous SNV	exon8	c.C1567T	p.R523C	PGKQELGIHLAARGPKDQLLVAHHS	PGKQELGIHLAACGPKDQLLVAHHS	1.0	4.0	-	-	4158_X:54784940-54784940 G>A_PGKQELGIHLAACGPKDQLLVAHHS	0.0
12:133698183-133698183 G>A	1.0	3903	MELANOMA	-	-	-	-	ZNF891	uc031qkn.1,p.P108S|ENST00000537226,p.P108S|ENST00000397313,p.P108S|NM_001277291,p.P108S|uc031qkm.1,p.P108S	protein_coding	uc031qkn.1	nonsynonymous SNV	exon1	c.C322T	p.P108S	DQEEIRNMKKRIPQAICPDQKIQPK	DQEEIRNMKKRISQAICPDQKIQPK	4.0	3.0	-	-	3903_12:133698183-133698183 G>A_DQEEIRNMKKRISQAICPDQKIQPK	0.0
11:62298739-62298739 C>A	1.0	4244	COLORECTAL	-	-	-	-	AHNAK	NM_001620,p.L1050F|ENST00000378024,p.L1050F|uc001ntl.3,p.L1050F	protein_coding, processed_transcript	uc001ntl.3	nonsynonymous SNV	exon5	c.G3150T	p.L1050F	APDLSLEGPEGKLKGPKFKMPEMHF	APDLSLEGPEGKFKGPKFKMPEMHF	9.0	2.0	-	-	4244_11:62298739-62298739 C>A_APDLSLEGPEGKFKGPKFKMPEMHF	0.0
6:21595145-21595145 A>C	1.0	4317	COLORECTAL	-	-	-	-	SOX4	NM_003107,p.K127T|uc003ndi.3,p.K127T|ENST00000543472,p.K127T|ENST00000244745,p.K127T	protein_coding	uc003ndi.3	nonsynonymous SNV	exon1	c.A380C	p.K127T	LRLKHMADYPDYKYRPRKKVKSGNA	LRLKHMADYPDYTYRPRKKVKSGNA	9.0	2.0	-	-	4317_6:21595145-21595145 A>C_LRLKHMADYPDYTYRPRKKVKSGNA	0.0
3:52547920-52547920 G>A	0.0	2591	MELANOMA	-	-	-	-	STAB1	uc003dej.3,p.D1124N|NM_015136,p.D1124N|ENST00000321725,p.D1124N	retained_intron, protein_coding	uc003dej.3	nonsynonymous SNV	exon32	c.G3370A	p.D1124N	HILSQVLLPPRGDVPGGQGLLQQLD	HILSQVLLPPRGNVPGGQGLLQQLD	2.0	9.0	-	-	2591_3:52547920-52547920 G>A_HILSQVLLPPRGNVPGGQGLLQQLD	0.0
7:106830701-106830701 C>T	1.0	3795	MELANOMA	-	-	-	-	HBP1	NM_012257,p.P336S|NM_001244262,p.P346S|ENST00000485846,p.P336S|ENST00000468410,p.P336S|uc003vdy.3,p.P336S|uc003vdz.3,p.P336S|uc003veb.1,p.P336S|ENST00000222574,p.P336S|uc003vea.3,p.P336S|ENST00000498408,p.P328S|uc011klv.2,p.P346S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011klv.2	nonsynonymous SNV	exon8	c.C1036T	p.P346S	PCCEVHIGDVCLPPGHPDAINFDDS	PCCEVHIGDVCLSPGHPDAINFDDS	8.0	6.0	-	-	3795_7:106830701-106830701 C>T_PCCEVHIGDVCLSPGHPDAINFDDS	0.0
12:8212190-8212190 C>G	0.0	4134	NSCLC	-	-	-	-	C3AR1	ENST00000307637,p.E198Q|uc021quj.1,p.E198Q|uc001qtv.1,p.E198Q|NM_004054,p.E198Q	protein_coding	uc021quj.1	nonsynonymous SNV	exon1	c.G592C	p.E198Q	DFYGDPLENRSLENIVQPPGEMNDR	DFYGDPLENRSLQNIVQPPGEMNDR	7.0	3.0	-	-	4134_12:8212190-8212190 C>G_DFYGDPLENRSLQNIVQPPGEMNDR	0.0
1:181767510-181767510 C>T	0.0	3903	MELANOMA	-	-	-	-	CACNA1E	ENST00000358338,p.P2050L|ENST00000526775,p.P2099L|ENST00000360108,p.P2142L|NM_000721,p.P2118L|ENST00000367570,p.P2118L|uc009wxt.3,p.P2161L|NM_001205293,p.P2161L|NM_001205294,p.P2099L|uc009wxs.3,p.P2099L|uc001gow.3,p.P2118L|ENST00000367573,p.P2161L|ENST00000367567,p.P1725L|ENST00000357570,p.P2112L	retained_intron, protein_coding	uc009wxt.3	nonsynonymous SNV	exon48	c.C6482T	p.P2161L	TSTPRRSRRQLPPVPPKPRPLLSYS	TSTPRRSRRQLPLVPPKPRPLLSYS	1.0	10.0	-	-	3903_1:181767510-181767510 C>T_TSTPRRSRRQLPLVPPKPRPLLSYS	0.0
11:66625319-66625319 C>G	1.0	4345	COLORECTAL	-	-	-	-	LRFN4	uc001ojr.3,p.A35G|uc001ojq.1,p.A35G|ENST00000309602,p.A35G|NM_024036,p.A35G|ENST00000393952,p.A35G	protein_coding, processed_transcript	uc001ojr.3	nonsynonymous SNV	exon1	c.C104G	p.A35G	CQNLSESLSTLCAHRGLLFVPPNVD	CQNLSESLSTLCGHRGLLFVPPNVD	6.0	2.0	-	-	4345_11:66625319-66625319 C>G_CQNLSESLSTLCGHRGLLFVPPNVD	0.0
3:151046649-151046661 AGCCAAAGTATTC>-	0.0	4326	BREAST	-	-	-	-	P2RY13	uc003eyv.2,p.L61fs|NM_176894,p.L61fs|ENST00000325602,p.L61fs	protein_coding	uc003eyv.2	frameshift deletion	exon2	c.183_195del	p.L61fs	ALYTVVFLTGILLNTLALWVFVHIPS	ALYTVVFLTGILLCGCLFTSPAPPPSSSTSKTLWWPT	5.0	2.0	-	-	4326_3:151046649-151046661 AGCCAAAGTATTC>-_ALYTVVFLTGILLCGCLFTSPAPPPSSSTSKTLWWPT	0.0
9:109690138-109690138 G>T	0.0	4238	COLORECTAL	-	-	-	-	ZNF462	ENST00000374686,p.E198D|uc004bcz.3,p.E1315D|ENST00000441147,p.E160D|NM_021224,p.E1315D|uc004bda.3,p.E1163D|ENST00000457913,p.E1315D|ENST00000277225,p.E1315D|uc010mto.3,p.E1163D	protein_coding, processed_transcript	uc010mto.3	nonsynonymous SNV	exon1	c.G3489T	p.E1163D	FLDGLIEAGYHCEWCIYSHTEPNGL	FLDGLIEAGYHCDWCIYSHTEPNGL	6.0	5.0	-	-	4238_9:109690138-109690138 G>T_FLDGLIEAGYHCDWCIYSHTEPNGL	0.0
14:58724647-58724647 T>G	1.0	4071	COLORECTAL	-	-	-	-	PSMA3	ENST00000412908,p.L112R|ENST00000557508,p.L37R|uc001xdj.2,p.L112R|uc021rtt.1,p.L37R|NM_002788,p.L112R|NM_152132,p.L112R|uc001xdk.2,p.L112R|ENST00000216455,p.L112R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021rtt.1	nonsynonymous SNV	exon4	c.T110G	p.L37R	RSNFGYNIPLKHLADRVAMYVHAYT	RSNFGYNIPLKHRADRVAMYVHAYT	10.0	7.0	-	-	4071_14:58724647-58724647 T>G_RSNFGYNIPLKHRADRVAMYVHAYT	0.0
6:28093324-28093324 C>T	0.0	3775	CERVICAL	-	-	-	-	ZSCAN16	ENST00000340487,p.H35Y|uc011dky.1,p.H35Y|NM_025231,p.H35Y|uc003nkm.3,p.H35Y	protein_coding	uc011dky.1	nonsynonymous SNV	exon2	c.C103T	p.H35Y	WGQDSSSQKCSPHRRELYRQHFRKL	WGQDSSSQKCSPYRRELYRQHFRKL	5.0	7.0	-	-	3775_6:28093324-28093324 C>T_WGQDSSSQKCSPYRRELYRQHFRKL	0.0
5:139216788-139216788 G>A	1.0	4317	COLORECTAL	-	-	ID=COSM1061577;OCCURENCE=1(endometrium)	-	PSD2	ENST00000274710,p.A544T|NM_032289,p.A544T|uc003leu.1,p.A544T	protein_coding	uc003leu.1	nonsynonymous SNV	exon11	c.G1630A	p.A544T	TPRGRRGWKKFYAVLKGTILYLQKD	TPRGRRGWKKFYTVLKGTILYLQKD	4.0	10.0	-	-	4317_5:139216788-139216788 G>A_TPRGRRGWKKFYTVLKGTILYLQKD	0.0
7:98581730-98581730 T>A	1.0	3713	MELANOMA	-	-	-	1	TRRAP	uc011kis.2,p.Y2988N|ENST00000355540,p.Y2988N|uc003upr.3,p.Y2705N|ENST00000446306,p.Y2988N|NM_003496,p.Y2988N	retained_intron, protein_coding	uc011kis.2	nonsynonymous SNV	exon59	c.T8962A	p.Y2988N	WRQHHYQAIVTAYENSSQHDPSSNN	WRQHHYQAIVTANENSSQHDPSSNN	5.0	9.0	-	-	3713_7:98581730-98581730 T>A_WRQHHYQAIVTANENSSQHDPSSNN	0.0
15:33893638-33893638 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	RYR3	uc010bar.3,p.S603T|uc001zhi.3,p.S603T|NM_001243996,p.S603T|ENST00000415757,p.S603T|NM_001036,p.S603T|ENST00000389232,p.S603T	retained_intron, protein_coding, processed_transcript	uc010bar.3	nonsynonymous SNV	exon17	c.T1807A	p.S603T	HGRNHKVLDILCSLCLCNGVAVRAN	HGRNHKVLDILCTLCLCNGVAVRAN	3.0	8.0	-	-	4258_15:33893638-33893638 T>A_HGRNHKVLDILCTLCLCNGVAVRAN	0.0
8:143570702-143570702 C>T	1.0	4298	COLORECTAL	0.0005	-	-	-	BAI1	uc003ywm.3,p.T845M|ENST00000521208,p.T845M|ENST00000323289,p.T845M|ENST00000517894,p.T845M|NM_001702,p.T845M	retained_intron, protein_coding, nonsense_mediated_decay	uc003ywm.3	nonsynonymous SNV	exon15	c.C2534T	p.T845M	RNLGSFLALQRNTTVLNSKVISVTV	RNLGSFLALQRNMTVLNSKVISVTV	5.0	9.0	-	-	4298_8:143570702-143570702 C>T_RNLGSFLALQRNMTVLNSKVISVTV	0.0
14:24608783-24608783 C>G	1.0	4234	NSCLC	-	-	-	-	EMC9	ENST00000560403,p.E32Q|NM_016049,p.E106Q|uc001wmi.3,p.E106Q|ENST00000419198,p.E106Q|ENST00000216799,p.E106Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wmi.3	nonsynonymous SNV	exon4	c.G316C	p.E106Q	GPLALKIAGRIAEFFPDAVLIMLDN	GPLALKIAGRIAQFFPDAVLIMLDN	8.0	9.0	-	-	4234_14:24608783-24608783 C>G_GPLALKIAGRIAQFFPDAVLIMLDN	0.0
11:9182268-9182268 C>G	1.0	4234	NSCLC	-	-	-	-	DENND5A	ENST00000526707,p.V786L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000526707	nonsynonymous SNV	exon11	c.G2356C	p.V786L	DLLERIWSHGLQVKQEYFLIQNVGS	DLLERIWSHGLQLKQEYFLIQNVGS	9.0	9.0	-	-	4234_11:9182268-9182268 C>G_DLLERIWSHGLQLKQEYFLIQNVGS	0.0
10:26506796-26506798 GCC>-	0.0	4284	COLORECTAL	-	-	-	-	GAD2	uc001isq.2,p.54_55del|NM_001134366,p.54_55del|ENST00000376261,p.54_55del|uc001isp.2,p.54_55del|uc009xkr.3,p.54_55del|NM_000818,p.54_55del|ENST00000259271,p.54_55del|ENST00000428517,p.54_55del	protein_coding	uc009xkr.3	nonframeshift deletion	exon3	c.162_164del	p.54_55del	NKLCALLYGDAEKPAESGGSQPPRA	NKLCALLYGDAEKAESGGSQPPRAA	3.0	2.0	-	-	4284_10:26506796-26506798 GCC>-_NKLCALLYGDAEKAESGGSQPPRAA	0.0
12:21242969-21242969 G>T	1.0	4234	NSCLC	-	-	-	-	SLCO1B7	uc010sim.2,p.V665L|uc010sin.2,p.V618L|ENST00000553473,p.V726L|ENST00000421593,p.V618L|ENST00000554957,p.V665L|NM_001009562,p.V618L|uc010sil.2,p.V726L|ENST00000540229,p.V726L|ENST00000381541,p.V665L	protein_coding, nonsense_mediated_decay	uc010sin.2	nonsynonymous SNV	exon13	c.G1852T	p.V618L	GKDTKVLENERQVMDEANLEFLNDS	GKDTKVLENERQLMDEANLEFLNDS	7.0	8.0	-	-	4234_12:21242969-21242969 G>T_GKDTKVLENERQLMDEANLEFLNDS	0.0
1:152325064-152325064 T>G	0.0	4258	ENDOMETRIAL	-	-	-	-	FLG2	uc001ezw.4,p.D1733A|NM_001014342,p.D1733A|ENST00000388718,p.D1733A	protein_coding	uc001ezw.4	nonsynonymous SNV	exon3	c.A5198C	p.D1733A	TGRRGSGHSEYSDSEGYSGVSHTHS	TGRRGSGHSEYSASEGYSGVSHTHS	1.0	5.0	-	-	4258_1:152325064-152325064 T>G_TGRRGSGHSEYSASEGYSGVSHTHS	0.0
7:7636032-7636032 C>T	1.0	3713	MELANOMA	-	-	-	-	MIOS	uc003srg.3,p.P316S|ENST00000340080,p.P781S|NM_019005,p.P781S|uc010ktq.3,p.P176S|uc003srf.3,p.P781S|ENST00000405785,p.P781S	retained_intron, protein_coding, processed_transcript	uc010ktq.3	nonsynonymous SNV	exon5	c.C526T	p.P176S	KSKVTSCPGCRKPLPRCALCLINMG	KSKVTSCPGCRKSLPRCALCLINMG	7.0	8.0	-	-	3713_7:7636032-7636032 C>T_KSKVTSCPGCRKSLPRCALCLINMG	0.0
5:140605446-140605446 G>A	0.0	4235	COLORECTAL	-	-	ID=COSM1062841;OCCURENCE=1(central_nervous_system),1(urinary_tract),1(large_intestine),1(endometrium)	-	PCDHB14	uc003ljb.3,p.R790Q|ENST00000515856,p.R637Q|NM_018934,p.R790Q|ENST00000239449,p.R790Q	protein_coding	uc003ljb.3	nonsynonymous SNV	exon1	c.G2369A	p.R790Q	DTGRNMGEIENFRNSFGLNIQ	DTGRNMGEIENFQNSFGLNIQ	8.0	6.0	-	-	4235_5:140605446-140605446 G>A_DTGRNMGEIENFQNSFGLNIQ	0.0
14:24845660-24845660 A>C	1.0	4246	COLORECTAL	-	-	-	-	NFATC4	ENST00000555453,p.E727D|uc010tor.2,p.E739D|ENST00000555167,p.E274D|ENST00000553879,p.E669D|ENST00000554661,p.E669D|NM_004554,p.E739D|uc010ton.2,p.E752D|NM_001288802,p.E727D|uc010too.2,p.E752D|NM_001198965,p.E739D|ENST00000557451,p.E669D|uc010alt.3,p.E771D|uc010tol.2,p.E802D|ENST00000556759,p.E274D|ENST00000554473,p.E274D|ENST00000554591,p.E802D|uc010tok.2,p.E802D|uc010alv.3,p.E727D|ENST00000554966,p.E752D|ENST00000557767,p.E27D|uc010tpa.2,p.E27D|ENST00000554050,p.E739D|uc010alr.3,p.E802D|uc010tox.2,p.E669D|NM_001198966,p.E669D|uc010toy.2,p.E274D|uc010toq.2,p.E771D|ENST00000539237,p.E771D|uc010tov.2,p.E727D|ENST00000555393,p.E27D|ENST00000554344,p.E669D|ENST00000422617,p.E727D|ENST00000553469,p.E771D|ENST00000555802,p.E27D|ENST00000556279,p.E771D|uc010top.2,p.E771D|ENST00000424781,p.E752D|NM_001136022,p.E802D|NM_001198967,p.E802D|uc010tom.2,p.E752D|uc001wpc.3,p.E739D|ENST00000555590,p.E752D|ENST00000250373,p.E739D|uc010tpb.2,p.E27D|uc010tot.2,p.E727D|ENST00000413692,p.E802D|uc010tos.2,p.E669D|ENST00000553708,p.E739D|uc001wpd.3,p.E274D|uc010toz.2,p.E274D|ENST00000556169,p.E727D|uc010tow.2,p.E669D|uc010tou.2,p.E669D	retained_intron, protein_coding, processed_transcript	uc010tpb.2	nonsynonymous SNV	exon4	c.A81C	p.E27D	HEDPACETPYLSEGFGYGMPPLYPQ	HEDPACETPYLSDGFGYGMPPLYPQ	10.0	5.0	-	-	4246_14:24845660-24845660 A>C_HEDPACETPYLSDGFGYGMPPLYPQ	0.0
15:48413264-48413264 C>T	1.0	4000	MELANOMA	-	-	ID=COSM1517173;OCCURENCE=1(lung)	-	SLC24A5	ENST00000449382,p.T8I|ENST00000482911,p.T8I|NM_205850,p.T8I|uc001zwd.3,p.T8I|uc010bel.3,p.T8I|uc001zwe.3,p.T8I|ENST00000341459,p.T8I	retained_intron, protein_coding	uc010bel.3	nonsynonymous SNV	exon1	c.C23T	p.T8I	MQTKGGQTWARRALLLGILW	MQTKGGQIWARRALLLGILW	10.0	9.0	-	-	4000_15:48413264-48413264 C>T_MQTKGGQIWARRALLLGILW	0.0
1:160247932-160247932 A>G	1.0	4316	COLORECTAL	-	-	-	-	PEX19	ENST00000485079,p.L159P	protein_coding	ENST00000485079	nonsynonymous SNV	exon5	c.T476C	p.L159P	FFCGSQWVYGPWLTYVETGFTMLAW	FFCGSQWVYGPWPTYVETGFTMLAW	7.0	7.0	-	-	4316_1:160247932-160247932 A>G_FFCGSQWVYGPWPTYVETGFTMLAW	0.0
7:97822898-97822898 G>A	1.0	4335	COLORECTAL	-	-	-	-	LMTK2	NM_014916,p.E1041K|uc003upd.2,p.E1041K|ENST00000297293,p.E1041K	protein_coding, processed_transcript	uc003upd.2	nonsynonymous SNV	exon11	c.G3121A	p.E1041K	DSGYETENLESPEWTLHPAPEGTAD	DSGYETENLESPKWTLHPAPEGTAD	7.0	6.0	-	-	4335_7:97822898-97822898 G>A_DSGYETENLESPKWTLHPAPEGTAD	0.0
1:205899103-205899103 C>T	0.0	4287	COLORECTAL	-	-	-	-	SLC26A9	uc001hdp.3,p.G212S|NM_052934,p.G212S|ENST00000367134,p.G212S|uc001hdq.3,p.G212S|NM_134325,p.G212S|ENST00000340781,p.G212S|ENST00000367135,p.G212S	retained_intron, protein_coding	uc001hdq.3	nonsynonymous SNV	exon6	c.G634A	p.G212S	SESFIRGFMTAAGLQILISVLKYIF	SESFIRGFMTAASLQILISVLKYIF	3.0	8.0	-	-	4287_1:205899103-205899103 C>T_SESFIRGFMTAASLQILISVLKYIF	0.0
10:134038742-134038742 C>T	0.0	4110	BILE DUCT	-	-	-	-	STK32C	ENST00000368625,p.G304R|NM_173575,p.G291R|ENST00000298630,p.G291R|uc001lle.1,p.G291R|ENST00000462160,p.G230R|uc001lld.1,p.G174R|uc010quu.1,p.G304R|ENST00000368622,p.G174R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010quu.1	nonsynonymous SNV	exon7	c.G910A	p.G304R	WSVGVMAYELLRGWRPYDIHSSNAV	WSVGVMAYELLRRWRPYDIHSSNAV	7.0	6.0	-	-	4110_10:134038742-134038742 C>T_WSVGVMAYELLRRWRPYDIHSSNAV	0.0
5:131046328-131046328 G>A	1.0	4326	BREAST	-	-	-	-	FNIP1	uc010jdm.1,p.R172W|ENST00000307954,p.R172W|uc003kvs.1,p.R217W|ENST00000510461,p.R217W|uc003kvu.3,p.R217W|ENST00000511848,p.R217W|NM_133372,p.R217W	protein_coding	uc010jdm.1	nonsynonymous SNV	exon6	c.C514T	p.R172W	GNIGLSQFCSPRRAFSEQGPLRLIR	GNIGLSQFCSPRWAFSEQGPLRLIR	9.0	10.0	-	-	4326_5:131046328-131046328 G>A_GNIGLSQFCSPRWAFSEQGPLRLIR	0.0
19:57088263-57088263 T>A	0.0	3775	CERVICAL	-	-	-	-	ZNF470	ENST00000330619,p.F156I|uc002qnl.4,p.F156I|ENST00000391709,p.F156I|NM_001001668,p.F156I	protein_coding, processed_transcript	uc002qnl.4	nonsynonymous SNV	exon6	c.T466A	p.F156I	LFERELVNQKTHFRQETITHIDTLI	LFERELVNQKTHIRQETITHIDTLI	3.0	8.0	-	-	3775_19:57088263-57088263 T>A_LFERELVNQKTHIRQETITHIDTLI	0.0
12:58010123-58010123 C>T	1.0	4287	COLORECTAL	-	-	-	-	ARHGEF25	uc001spb.4,p.R493W|NM_001111270,p.R532W|uc009zpy.4,p.R532W|ENST00000286494,p.R493W|uc001spa.4,p.R387W|NM_182947,p.R493W|ENST00000333972,p.R532W	retained_intron, protein_coding, processed_transcript	uc009zpy.4	nonsynonymous SNV	exon15	c.C1594T	p.R532W	YQRRESQTNSLGRPRGPGVGSPGRI	YQRRESQTNSLGWPRGPGVGSPGRI	6.0	9.0	-	-	4287_12:58010123-58010123 C>T_YQRRESQTNSLGWPRGPGVGSPGRI	0.0
7:1589772-1589772 C>T	1.0	4320	COLORECTAL	-	-	-	-	TMEM184A	ENST00000319010,p.R180H|ENST00000297477,p.R180H|NM_001097620,p.R180H|uc003skv.4,p.R180H	retained_intron, protein_coding, nonsense_mediated_decay	uc003skv.4	nonsynonymous SNV	exon5	c.G539A	p.R180H	CLRGMTYSIGFLRFCKQATLQFCLV	CLRGMTYSIGFLHFCKQATLQFCLV	7.0	10.0	-	-	4320_7:1589772-1589772 C>T_CLRGMTYSIGFLHFCKQATLQFCLV	0.0
8:144681971-144681971 A>T	1.0	4000	MELANOMA	-	-	-	-	TIGD5	NM_032862,p.H633L|ENST00000504548,p.H633L|ENST00000321385,p.H584L|uc003yyx.2,p.H633L	protein_coding	uc003yyx.2	nonsynonymous SNV	exon1	c.A1898T	p.H633L	LISMARRLGGIGHTPAGPYDGV	LISMARRLGGIGLTPAGPYDGV	5.0	1.0	-	-	4000_8:144681971-144681971 A>T_LISMARRLGGIGLTPAGPYDGV	0.0
1:95609556-95609556 A>C	0.0	4345	COLORECTAL	-	-	-	-	TMEM56,TMEM56-RWDD3	NM_152487,p.K33N|NM_001199679,p.K33N|uc001drb.3,p.K33N|NM_001199691,p.K33N|ENST00000455656,p.K33N|uc001drd.4,p.K33N|ENST00000370203,p.K33N|ENST00000604534,p.K33N|ENST00000456991,p.K33N|uc021oqe.1,p.K33N	protein_coding, processed_transcript	uc021oqe.1	nonsynonymous SNV	exon2	c.A99C	p.K33N	LLFYFVSYWFSAKVSPGFNSLSFKK	LLFYFVSYWFSANVSPGFNSLSFKK	5.0	2.0	-	-	4345_1:95609556-95609556 A>C_LLFYFVSYWFSANVSPGFNSLSFKK	0.0
12:49165747-49165747 C>T	1.0	3879	MELANOMA	-	-	-	-	ADCY6	uc001rsi.4,p.E880K|uc010slw.1,p.E164K|uc001rsj.4,p.E933K|NM_020983,p.E880K|uc001rsh.4,p.E933K|NM_015270,p.E933K|ENST00000550422,p.E880K|ENST00000357869,p.E880K|ENST00000307885,p.E933K	retained_intron, protein_coding, processed_transcript	uc010slw.1	nonsynonymous SNV	exon6	c.G490A	p.E164K	RLDFLWKLQATGEKEEMEELQAYNR	RLDFLWKLQATGKKEEMEELQAYNR	7.0	3.0	-	-	3879_12:49165747-49165747 C>T_RLDFLWKLQATGKKEEMEELQAYNR	0.0
14:80963862-80963862 C>T	1.0	3713	MELANOMA	-	-	-	-	CEP128	ENST00000555265,p.G1082E|uc031qpo.1,p.G1109E|ENST00000281129,p.G1082E|uc001xux.2,p.G1082E|NM_152446,p.G1082E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031qpo.1	nonsynonymous SNV	exon26	c.G3326A	p.G1109E	DSASNKEDATMNGTSSQPKKEEYGS	DSASNKEDATMNETSSQPKKEEYGS	4.0	9.0	-	-	3713_14:80963862-80963862 C>T_DSASNKEDATMNETSSQPKKEEYGS	0.0
11:95712840-95712840 C>T	1.0	4244	COLORECTAL	-	-	-	1	MAML2	uc001pfw.1,p.G915R|ENST00000524717,p.G915R|NM_032427,p.G915R	protein_coding	uc001pfw.1	nonsynonymous SNV	exon5	c.G2743A	p.G915R	QNNPMMPRPPTLGPSNNNNVATFGA	QNNPMMPRPPTLRPSNNNNVATFGA	6.0	6.0	-	-	4244_11:95712840-95712840 C>T_QNNPMMPRPPTLRPSNNNNVATFGA	0.0
19:6307240-6307240 G>C	0.0	4213	COLORECTAL	-	-	-	-	ACER1	uc002mel.2,p.L184V|NM_133492,p.L184V|ENST00000301452,p.L184V	protein_coding	uc002mel.2	nonsynonymous SNV	exon5	c.C550G	p.L184V	LIEVSVVLWAVALTSWISDRLLCSF	LIEVSVVLWAVAVTSWISDRLLCSF	2.0	7.0	-	-	4213_19:6307240-6307240 G>C_LIEVSVVLWAVAVTSWISDRLLCSF	0.0
14:35554813-35554813 C>T	1.0	4278	COLORECTAL	-	-	-	-	PPP2R3C	NM_017917,p.D449N|ENST00000555219,p.D124N|uc010tpr.2,p.D333N|uc001wst.3,p.D333N|ENST00000261475,p.D449N|uc001wss.3,p.D449N	retained_intron, protein_coding, nonsense_mediated_decay	uc010tpr.2	nonsynonymous SNV	exon13	c.G997A	p.D333N	EALVANDSENSADLDDT	EALVANDSENSANLDDT	9.0	7.0	-	-	4278_14:35554813-35554813 C>T_EALVANDSENSANLDDT	0.0
3:29910395-29910395 G>T	0.0	4316	COLORECTAL	-	-	-	-	RBMS3	uc003cem.3,p.K227N|ENST00000445033,p.K228N|NM_001003793,p.K228N|ENST00000396583,p.K228N|ENST00000383766,p.K227N|NM_014483,p.K228N|NM_001003792,p.K227N|uc003cel.3,p.K228N|NM_001177712,p.K228N|ENST00000456853,p.K228N|uc010hfq.3,p.K228N|ENST00000434693,p.K227N|ENST00000452462,p.K228N|ENST00000383767,p.K228N|uc003cek.3,p.K228N|NM_001177711,p.K228N|uc010hfr.3,p.K228N|ENST00000273139,p.K228N	retained_intron, protein_coding, processed_transcript	uc010hfr.3	nonsynonymous SNV	exon7	c.G684T	p.K228N	EPLLCKFADGGQKKRQNQSKYTQNG	EPLLCKFADGGQNKRQNQSKYTQNG	5.0	8.0	-	-	4316_3:29910395-29910395 G>T_EPLLCKFADGGQNKRQNQSKYTQNG	0.0
3:50211766-50211766 C>T	1.0	4180	BREAST	-	-	-	-	SEMA3F	ENST00000002829,p.R147C|NM_004186,p.R147C|uc003cyj.3,p.R147C	retained_intron, protein_coding	uc003cyj.3	nonsynonymous SNV	exon5	c.C439T	p.R147C	TGAYNPMCTYVNRGRRAQATPWTQT	TGAYNPMCTYVNCGRRAQATPWTQT	9.0	8.0	-	-	4180_3:50211766-50211766 C>T_TGAYNPMCTYVNCGRRAQATPWTQT	0.0
19:34263554-34263554 C>G	0.0	4046	OVARIAN	-	-	-	-	CHST8	ENST00000438847,p.I287M|ENST00000434302,p.I287M|uc002nus.4,p.I287M|ENST00000262622,p.I287M|NM_001127896,p.I287M|uc002nut.4,p.I287M|NM_022467,p.I287M|NM_001127895,p.I287M|uc002nuu.3,p.I287M	protein_coding	uc002nuu.3	nonsynonymous SNV	exon4	c.C861G	p.I287M	PNSYYHPVFGKAILARYRANASREA	PNSYYHPVFGKAMLARYRANASREA	2.0	6.0	-	-	4046_19:34263554-34263554 C>G_PNSYYHPVFGKAMLARYRANASREA	0.0
18:77456034-77456034 G>A	1.0	3678	MELANOMA	-	-	-	-	CTDP1	ENST00000590635,p.M33I|NM_004715,p.M152I|uc002lni.2,p.M152I|ENST00000075430,p.M152I|ENST00000591598,p.M84I|uc010drd.2,p.M152I|uc002lnh.2,p.M152I|NM_001202504,p.M33I|NM_048368,p.M152I|ENST00000299543,p.M152I|uc021ult.1,p.M33I	retained_intron, protein_coding, processed_transcript	uc021ult.1	nonsynonymous SNV	exon3	c.G99A	p.M33I	KQQVPLSTATVSMVHSVPELMVSSE	KQQVPLSTATVSIVHSVPELMVSSE	6.0	7.0	-	-	3678_18:77456034-77456034 G>A_KQQVPLSTATVSIVHSVPELMVSSE	0.0
19:57325314-57325314 T>A	0.0	4129	NSCLC	-	-	-	-	PEG3	ENST00000423103,p.Q1499L|uc002qnu.2,p.Q1499L|NM_001146184,p.Q1499L|NM_001146187,p.Q1375L|ENST00000326441,p.Q1499L|NM_006210,p.Q1499L|ENST00000593695,p.Q1373L|uc002qnx.2,p.Q1373L|uc002qnw.2,p.Q1375L|ENST00000599577,p.Q1499L|ENST00000599534,p.Q1499L|NM_001146185,p.Q1373L|uc010etr.2,p.Q1499L|uc002qnv.2,p.Q1499L|NM_001146186,p.Q1499L|uc002qnt.2,p.Q1470L|ENST00000598410,p.Q1375L	protein_coding, processed_transcript	uc010etr.2	nonsynonymous SNV	exon9	c.A4496T	p.Q1499L	IEDPEEGEDQEIQVEEPYYDCHECT	IEDPEEGEDQEILVEEPYYDCHECT	4.0	6.0	-	-	4129_19:57325314-57325314 T>A_IEDPEEGEDQEILVEEPYYDCHECT	0.0
1:21808184-21808184 C>T	0.0	4160	COLORECTAL	-	-	-	-	NBPF3	uc001bes.4,p.P454S|ENST00000434838,p.P454S|ENST00000454000,p.P440S|NM_001256417,p.P440S|ENST00000342104,p.P498S|ENST00000318249,p.P510S|uc001ber.4,p.P510S|uc009vqb.4,p.P498S|uc010odm.3,p.P440S|NM_001256416,p.P498S|NM_032264,p.P510S|ENST00000318220,p.P454S	protein_coding, processed_transcript	uc010odm.3	nonsynonymous SNV	exon12	c.C1318T	p.P440S	RWYSTPFSYPELPDSCQPYGSCFYS	RWYSTPFSYPELSDSCQPYGSCFYS	4.0	1.0	-	-	4160_1:21808184-21808184 C>T_RWYSTPFSYPELSDSCQPYGSCFYS	0.0
5:140237240-140237240 C>T	0.0	4346	COLORECTAL	-	-	ID=COSM3393217,COSM736163,COSM736164;OCCURENCE=1(lung),1(pancreas),1(large_intestine)	-	PCDHA10	uc011dad.2,p.A536V|uc003lhx.2,p.A536V|NM_031859,p.A536V|ENST00000307360,p.A536V|NM_018901,p.A536V	protein_coding	uc011dad.2	nonsynonymous SNV	exon1	c.C1607T	p.A536V	HEELELLQFQVSARDGGVPPLGSNL	HEELELLQFQVSVRDGGVPPLGSNL	3.0	5.0	-	-	4346_5:140237240-140237240 C>T_HEELELLQFQVSVRDGGVPPLGSNL	0.0
22:38690408-38690408 G>A	1.0	4238	COLORECTAL	-	-	-	-	CSNK1E	ENST00000403904,p.R340W|NM_152221,p.R340W|ENST00000400206,p.R340W|ENST00000359867,p.R340W|ENST00000396832,p.R340W|uc003avm.2,p.R340W|NM_001894,p.R340W|uc003avk.3,p.R340W|uc003avj.3,p.R340W|NM_001289912,p.R340W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003avm.2	nonsynonymous SNV	exon12	c.C1018T	p.R340W	LPPGPPTGATANRLRSAAEPVASTP	LPPGPPTGATANWLRSAAEPVASTP	10.0	8.0	-	-	4238_22:38690408-38690408 G>A_LPPGPPTGATANWLRSAAEPVASTP	0.0
9:127119146-127119146 A>G	1.0	4180	BREAST	-	-	-	-	PSMB7	uc004boj.4,p.F207L|NM_002799,p.F207L|ENST00000259457,p.F207L	protein_coding, processed_transcript	uc004boj.4	nonsynonymous SNV	exon7	c.T619C	p.F207L	KNLVSEAIAAGIFNDLGSGSNIDLC	KNLVSEAIAAGILNDLGSGSNIDLC	10.0	9.0	-	-	4180_9:127119146-127119146 A>G_KNLVSEAIAAGILNDLGSGSNIDLC	0.0
9:43625984-43625984 C>A	0.0	4259	COLORECTAL	-	-	-	-	SPATA31A6	ENST00000332857,p.W901C|NM_001145196,p.W901C|uc011lrb.2,p.W901C	protein_coding, processed_transcript	uc011lrb.2	nonsynonymous SNV	exon4	c.G2703T	p.W901C	KQFQRAPRGIPSWNDHGPLKPPPAG	KQFQRAPRGIPSCNDHGPLKPPPAG	1.0	10.0	-	-	4259_9:43625984-43625984 C>A_KQFQRAPRGIPSCNDHGPLKPPPAG	0.0
18:34752963-34752963 C>A	1.0	4110	BILE DUCT	0.0005	-	-	-	KIAA1328	uc002lac.1,p.A340E|ENST00000280020,p.A481E|uc002kzz.3,p.A481E|ENST00000586135,p.A233E|ENST00000591619,p.A477E|ENST00000435985,p.A233E|ENST00000543923,p.A373E|NM_020776,p.A481E|uc002lab.3,p.A233E	protein_coding, processed_transcript, nonsense_mediated_decay	uc002lac.1	nonsynonymous SNV	exon5	c.C1019A	p.A340E	PQRGTVTGVRKDASTSPMPTGSLKD	PQRGTVTGVRKDESTSPMPTGSLKD	6.0	10.0	-	-	4110_18:34752963-34752963 C>A_PQRGTVTGVRKDESTSPMPTGSLKD	0.0
7:99473836-99473836 G>T	0.0	4266	COLORECTAL	-	-	-	-	OR2AE1	NM_001005276,p.S274Y|ENST00000316368,p.S274Y|uc003usc.1,p.S274Y	protein_coding	uc003usc.1	nonsynonymous SNV	exon1	c.C821A	p.S274Y	RSQCTLLQNKVGSVFYSIITPTLNS	RSQCTLLQNKVGYVFYSIITPTLNS	2.0	10.0	-	-	4266_7:99473836-99473836 G>T_RSQCTLLQNKVGYVFYSIITPTLNS	0.0
10:118390759-118390759 G>C	0.0	3775	CERVICAL	-	-	-	-	PNLIPRP2	ENST00000537242,p.M236I	retained_intron, protein_coding, processed_transcript, polymorphic_pseudogene	ENST00000537242	nonsynonymous SNV	exon9	c.G708C	p.M236I	DSSPIVPSLGFGMSQKVGHLDFFPN	DSSPIVPSLGFGISQKVGHLDFFPN	1.0	5.0	-	-	3775_10:118390759-118390759 G>C_DSSPIVPSLGFGISQKVGHLDFFPN	0.0
9:36651812-36651812 C>T	1.0	3466	MELANOMA	-	-	-	-	MELK	ENST00000541717,p.R331C|NM_001256693,p.R137C|uc011lpr.3,p.R260C|uc011lps.3,p.R251C|ENST00000545008,p.R260C|uc011lpn.3,p.R331C|NM_001256685,p.R331C|uc010mll.4,p.R299C|uc011lpq.3,p.R137C|NM_001256687,p.R283C|NM_001256690,p.R260C|uc011lpp.3,p.R283C|NM_001256692,p.R200C|NM_001256691,p.R251C|uc011lpm.3,p.R200C|uc011lpo.3,p.R137C|NM_001256689,p.R299C|NM_014791,p.R331C|ENST00000536860,p.R283C|uc003zzn.4,p.R331C|ENST00000536987,p.R200C|ENST00000536329,p.R260C|NM_001256688,p.R260C|uc010mlm.4,p.R260C|ENST00000543751,p.R299C|ENST00000538311,p.R137C|ENST00000298048,p.R331C	protein_coding, processed_transcript	uc011lps.3	nonsynonymous SNV	exon10	c.C751T	p.R251C	LLLAKKARGKPVRLRLSSFSCGQAS	LLLAKKARGKPVCLRLSSFSCGQAS	6.0	9.0	-	-	3466_9:36651812-36651812 C>T_LLLAKKARGKPVCLRLSSFSCGQAS	0.0
4:164621984-164621984 C>T	0.0	2369	MELANOMA	0.0005	-	-	-	MARCH1	ENST00000274056,p.R48Q|ENST00000514618,p.R48Q|ENST00000503008,p.R48Q|ENST00000507270,p.R48Q|NM_001166373,p.R48Q|uc003iqs.2,p.R48Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003iqs.2	nonsynonymous SNV	exon4	c.G143A	p.R48Q	TLNEKSPGRSASRSSNISKASSPTT	TLNEKSPGRSASQSSNISKASSPTT	4.0	7.0	-	-	2369_4:164621984-164621984 C>T_TLNEKSPGRSASQSSNISKASSPTT	0.0
12:50472303-50472303 G>A	0.0	4155	MELANOMA	-	-	-	-	ASIC1	uc009zlo.4,p.D313N|ENST00000228468,p.D313N|uc001rvw.4,p.D313N|NM_001256830,p.D347N|uc001rvv.4,p.D313N|ENST00000447966,p.D313N|uc031qhf.1,p.D216N|uc009zln.4,p.D104N|NM_020039,p.D313N|uc021qxr.2,p.D347N|ENST00000552438,p.D347N|NM_001095,p.D313N	retained_intron, protein_coding, nonsense_mediated_decay	uc031qhf.1	nonsynonymous SNV	exon5	c.G646A	p.D216N	FFDSYSITACRIDCETRYLVENCNC	FFDSYSITACRINCETRYLVENCNC	4.0	8.0	-	-	4155_12:50472303-50472303 G>A_FFDSYSITACRINCETRYLVENCNC	0.0
1:240256230-240256230 C>T	0.0	3775	CERVICAL	-	-	-	-	FMN2	uc010pyd.2,p.S274F|ENST00000319653,p.S274F|uc010pye.2,p.S274F|NM_020066,p.S274F	protein_coding, processed_transcript	uc010pye.2	nonsynonymous SNV	exon1	c.C821T	p.S274F	EAPGSPDTEQALSALSDLPESLAAE	EAPGSPDTEQALFALSDLPESLAAE	2.0	7.0	-	-	3775_1:240256230-240256230 C>T_EAPGSPDTEQALFALSDLPESLAAE	0.0
5:3596480-3596480 C>A	0.0	4213	COLORECTAL	-	-	-	-	IRX1	uc003jde.3,p.S87R|ENST00000302006,p.S87R|NM_024337,p.S87R	protein_coding	uc003jde.3	nonsynonymous SNV	exon1	c.C261A	p.S87R	NYSAFLPYAADLSLFSQMGSQYELK	NYSAFLPYAADLRLFSQMGSQYELK	4.0	7.0	-	-	4213_5:3596480-3596480 C>A_NYSAFLPYAADLRLFSQMGSQYELK	0.0
8:145726639-145726639 C>A	1.0	4180	BREAST	-	-	-	-	PPP1R16A	NM_032902,p.R389S|uc003zdd.3,p.R389S|ENST00000292539,p.R389S|ENST00000435887,p.R389S|uc003zdf.3,p.R389S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zdf.3	nonsynonymous SNV	exon9	c.C1165A	p.R389S	PTSPEPPEDNDDRQTGAELRPPPPE	PTSPEPPEDNDDSQTGAELRPPPPE	10.0	7.0	-	-	4180_8:145726639-145726639 C>A_PTSPEPPEDNDDSQTGAELRPPPPE	0.0
9:130707841-130707841 C>T	1.0	4317	COLORECTAL	-	-	-	-	FAM102A	ENST00000373095,p.G241D|uc004bsx.2,p.G241D|NM_001035254,p.G241D|uc004bsw.1,p.G99D|ENST00000373084,p.G99D|NM_203305,p.G99D	retained_intron, protein_coding, processed_transcript	uc004bsx.2	nonsynonymous SNV	exon8	c.G722A	p.G241D	NSSYASQQSKISGYSTEHSRSSSLS	NSSYASQQSKISDYSTEHSRSSSLS	9.0	9.0	-	-	4317_9:130707841-130707841 C>T_NSSYASQQSKISDYSTEHSRSSSLS	0.0
3:178968705-178968705 G>A	1.0	3775	CERVICAL	-	-	-	-	KCNMB3	uc003fjm.3,p.S29L|ENST00000314235,p.S29L|NM_014407,p.S29L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003fjm.3	nonsynonymous SNV	exon2	c.C86T	p.S29L	ILLTRHRTAFPASGKKRETDYSDGD	ILLTRHRTAFPALGKKRETDYSDGD	6.0	10.0	-	-	3775_3:178968705-178968705 G>A_ILLTRHRTAFPALGKKRETDYSDGD	0.0
7:100686642-100686642 C>G	1.0	4213	COLORECTAL	-	-	-	-	MUC17	NM_001040105,p.T3982S|ENST00000379439,p.T3982S|uc003uxp.1,p.T3982S|ENST00000306151,p.T3982S	retained_intron, protein_coding, nonsense_mediated_decay	uc003uxp.1	nonsynonymous SNV	exon3	c.C11945G	p.T3982S	ELNTPSTSSSSTTTSFSTTKEFTTP	ELNTPSTSSSSTSTSFSTTKEFTTP	6.0	2.0	-	-	4213_7:100686642-100686642 C>G_ELNTPSTSSSSTSTSFSTTKEFTTP	0.0
19:10449579-10449579 G>A	0.0	3466	MELANOMA	-	-	-	-	ICAM3	NM_002162,p.P41L|ENST00000160262,p.P41L|uc002mob.2,p.P41L	retained_intron, protein_coding, nonsense_mediated_decay	uc002mob.2	nonsynonymous SNV	exon2	c.C122T	p.P41L	GQEFLLRVEPQNPVLSAGGSLFVNC	GQEFLLRVEPQNLVLSAGGSLFVNC	4.0	8.0	-	-	3466_19:10449579-10449579 G>A_GQEFLLRVEPQNLVLSAGGSLFVNC	0.0
4:41682037-41682037 G>T	1.0	3713	MELANOMA	-	-	-	-	LIMCH1	ENST00000512632,p.K717N|uc003gwe.4,p.K717N	protein_coding, processed_transcript	uc003gwe.4	nonsynonymous SNV	exon16	c.G2151T	p.K717N	VELVLSQKERYQKEQDKLKEEWEKA	VELVLSQKERYQNEQDKLKEEWEKA	4.0	4.0	-	-	3713_4:41682037-41682037 G>T_VELVLSQKERYQNEQDKLKEEWEKA	0.0
19:11493888-11493888 C>A	1.0	4287	COLORECTAL	-	-	-	-	EPOR	NM_000121,p.G46W|ENST00000592375,p.G46W|uc002mrj.2,p.G46W|ENST00000586890,p.G46W|ENST00000222139,p.G46W|ENST00000588859,p.G46W	retained_intron, protein_coding, nonsense_mediated_decay	uc002mrj.2	nonsynonymous SNV	exon2	c.G136T	p.G46W	KFESKAALLAARGPEELLCFTERLE	KFESKAALLAARWPEELLCFTERLE	5.0	10.0	-	-	4287_19:11493888-11493888 C>A_KFESKAALLAARWPEELLCFTERLE	0.0
13:95112365-95112365 C>T	0.0	4346	COLORECTAL	-	-	-	-	DCT	ENST00000446125,p.A387T|uc010afh.3,p.A387T|NM_001129889,p.A387T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010afh.3	nonsynonymous SNV	exon6	c.G1159A	p.A387T	FLNGTNALPHSAANDPIFVVISNRL	FLNGTNALPHSATNDPIFVVISNRL	2.0	1.0	-	-	4346_13:95112365-95112365 C>T_FLNGTNALPHSATNDPIFVVISNRL	0.0
14:70990676-70990676 G>A	0.0	4301	MELANOMA	-	-	-	-	ADAM20	NM_003814,p.P317S|uc021rvs.1,p.P317S|uc001xme.3,p.P317S|ENST00000256389,p.P317S	protein_coding	uc021rvs.1	nonsynonymous SNV	exon1	c.C949T	p.P317S	TGIDIWTASNPLPTSGDLDNVLEDF	TGIDIWTASNPLSTSGDLDNVLEDF	4.0	1.0	-	-	4301_14:70990676-70990676 G>A_TGIDIWTASNPLSTSGDLDNVLEDF	0.0
17:15516939-15516939 G>A	0.0	2556	MELANOMA	-	-	-	-	CDRT1	ENST00000395906,p.T330I|NM_006382,p.T330I|NM_001282540,p.T330I|ENST00000455584,p.T640I|uc002gor.1,p.T640I|uc002gov.4,p.T330I	retained_intron, protein_coding, nonsense_mediated_decay	uc002gov.4	nonsynonymous SNV	exon4	c.C989T	p.T330I	DLSAHGFIQNQITFLQGSYTRGIDP	DLSAHGFIQNQIIFLQGSYTRGIDP	3.0	4.0	-	-	2556_17:15516939-15516939 G>A_DLSAHGFIQNQIIFLQGSYTRGIDP	0.0
9:75542087-75542087 T>A	0.0	3775	CERVICAL	-	-	-	-	ALDH1A1	ENST00000446946,p.N150I|ENST00000419959,p.N150I|NM_000689,p.N150I|uc011lsh.2,p.N71I|uc004ajd.3,p.N150I|ENST00000376939,p.N150I|ENST00000297785,p.N150I	protein_coding, processed_transcript	uc011lsh.2	nonsynonymous SNV	exon5	c.A212T	p.N71I	DKIQGRTIPIDGNFFTYTRHEPIGV	DKIQGRTIPIDGIFFTYTRHEPIGV	10.0	7.0	CD8	-	3775_9:75542087-75542087 T>A_DKIQGRTIPIDGIFFTYTRHEPIGV	1.0
15:78486915-78486915 T>A	0.0	4149	OVARIAN	-	-	-	-	ACSBG1	ENST00000559114,p.K22M|ENST00000558130,p.K129M|uc002bdh.3,p.K129M|NM_001199377,p.K129M|NM_015162,p.K129M|ENST00000559241,p.K137M|uc010umy.2,p.K22M|uc010umw.2,p.K129M|ENST00000258873,p.K129M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010umy.2	nonsynonymous SNV	exon2	c.A65T	p.K22M	GDLIALGFKRQDKWEHISYSQYYLL	GDLIALGFKRQDMWEHISYSQYYLL	3.0	4.0	-	-	4149_15:78486915-78486915 T>A_GDLIALGFKRQDMWEHISYSQYYLL	0.0
10:112838383-112838383 G>T	1.0	4266	COLORECTAL	-	-	-	-	ADRA2A	NM_000681,p.W210L|uc001kzo.3,p.W210L|ENST00000280155,p.W210L	protein_coding	uc001kzo.3	nonsynonymous SNV	exon1	c.G629T	p.W210L	PAEPRCEINDQKWYVISSCIGSFFA	PAEPRCEINDQKLYVISSCIGSFFA	5.0	8.0	-	-	4266_10:112838383-112838383 G>T_PAEPRCEINDQKLYVISSCIGSFFA	0.0
12:30827609-30827609 C>A	0.0	4234	NSCLC	-	-	-	-	IPO8	ENST00000544829,p.A65S|NM_001190995,p.A65S|uc010sjt.2,p.A65S|ENST00000256079,p.A270S|ENST00000542464,p.A84S|uc001rjd.3,p.A270S|NM_006390,p.A270S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010sjt.2	nonsynonymous SNV	exon3	c.G193T	p.A65S	WWKCKKWALHIVARLFERYGSPGNV	WWKCKKWALHIVSRLFERYGSPGNV	8.0	10.0	-	-	4234_12:30827609-30827609 C>A_WWKCKKWALHIVSRLFERYGSPGNV	0.0
19:53611861-53611862 CA>-	1.0	4129	NSCLC	-	-	-	-	ZNF415	uc010yds.2,p.V479fs|ENST00000601493,p.V249fs|uc002qba.3,p.V249fs|ENST00000421033,p.V491fs|uc010ydt.2,p.V479fs|NM_001164309,p.V479fs|ENST00000455735,p.V527fs|ENST00000448501,p.V527fs|NM_018355,p.V479fs|uc002qav.3,p.V491fs|uc002qax.3,p.V527fs|NM_001136038,p.V479fs|uc002qaz.3,p.V527fs|ENST00000440291,p.V466fs|uc002qaw.3,p.V479fs|ENST00000500065,p.V479fs|uc002qau.3,p.V466fs|ENST00000243643,p.V479fs|uc002qay.3,p.V466fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ydt.2	frameshift deletion	exon4	c.1436_1437del	p.V479fs	PYKCNQCGKGFSVHSSLTTHQVIHT	PYKCNQCGKGFSAFKPNYPSGHPYWRKTLQM	8.0	2.0	-	-	4129_19:53611861-53611862 CA>-_PYKCNQCGKGFSAFKPNYPSGHPYWRKTLQM	0.0
2:25851074-25851074 G>A	1.0	3784	MELANOMA	-	-	-	-	DTNB	uc002rgh.4,p.L110F|NM_183360,p.L110F|ENST00000407038,p.L110F|uc002rgl.4,p.L110F|ENST00000496972,p.L53F|uc002rgq.4,p.L110F|NM_021907,p.L110F|uc002rgk.4,p.L110F|NM_033147,p.L110F|ENST00000404103,p.L110F|uc031rns.1,p.L110F|NM_001256308,p.L53F|ENST00000349996,p.L110F|ENST00000398951,p.L110F|ENST00000406818,p.L110F|ENST00000405222,p.L110F|NM_001256303,p.L110F|ENST00000303659,p.L110F|NM_001256304,p.L110F|uc010yko.3,p.L53F|NM_033148,p.L110F|ENST00000407661,p.L110F|uc002rgi.4,p.L110F|ENST00000407186,p.L110F|uc002rgr.1,p.L99F|NM_183361,p.L110F|ENST00000288642,p.L110F|uc002rgj.4,p.L110F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031rns.1	nonsynonymous SNV	exon3	c.C328T	p.L110F	STHQISVEQSISLLLNFMIAAYDSE	STHQISVEQSISFLLNFMIAAYDSE	6.0	7.0	-	-	3784_2:25851074-25851074 G>A_STHQISVEQSISFLLNFMIAAYDSE	0.0
3:119530438-119530438 G>T	1.0	4345	COLORECTAL	-	-	-	-	NR1I2	NM_022002,p.K167N|NM_003889,p.K128N|uc003edl.3,p.K16N|uc003edj.3,p.K128N|uc003edi.3,p.K128N|NM_033013,p.K128N|ENST00000466380,p.K128N|ENST00000337940,p.K167N|ENST00000393716,p.K128N|uc003edk.3,p.K167N	retained_intron, protein_coding	uc003edl.3	nonsynonymous SNV	exon1	c.G48T	p.K16N	EAVEERRALIKRKKSERTGTQPLGV	EAVEERRALIKRNKSERTGTQPLGV	9.0	10.0	-	-	4345_3:119530438-119530438 G>T_EAVEERRALIKRNKSERTGTQPLGV	0.0
1:158325101-158325101 A>C	0.0	4235	COLORECTAL	-	-	-	-	CD1E	uc010pie.2,p.I24L|NM_001185114,p.I24L|ENST00000444681,p.I24L|uc009wsv.3,p.I24L	protein_coding, processed_transcript	uc010pie.2	nonsynonymous SNV	exon2	c.A70C	p.I24L	CCPGENTADPFEIQILAGCRMNAPQ	CCPGENTADPFELQILAGCRMNAPQ	2.0	4.0	-	-	4235_1:158325101-158325101 A>C_CCPGENTADPFELQILAGCRMNAPQ	0.0
19:45150675-45150675 C>T	0.0	4155	MELANOMA	-	-	-	-	PVR	uc002ozn.3,p.S32L|NM_001135770,p.S87L|uc010ejs.3,p.S87L|NM_006505,p.S87L|NM_001135768,p.S87L|uc010xxb.2,p.S87L|ENST00000425690,p.S87L|ENST00000406449,p.S87L|ENST00000403059,p.S87L|uc010xxc.2,p.S87L|uc002ozm.3,p.S87L|ENST00000344956,p.S87L|NM_001135769,p.S87L	protein_coding, nonsense_mediated_decay	uc010xxc.2	nonsynonymous SNV	exon2	c.C260T	p.S87L	MAVFHQTQGPSYSESKRLEFVAARL	MAVFHQTQGPSYLESKRLEFVAARL	8.0	4.0	-	-	4155_19:45150675-45150675 C>T_MAVFHQTQGPSYLESKRLEFVAARL	0.0
6:24302242-24302242 C>G	1.0	4326	BREAST	-	-	-	-	DCDC2	ENST00000378454,p.V127L|NM_016356,p.V127L|NM_001195610,p.V127L|uc003ndy.3,p.V127L|uc003ndx.3,p.V127L	protein_coding	uc003ndy.3	nonsynonymous SNV	exon4	c.G379C	p.V127L	TEVKPVIHSRINVSARFRKPLQEPC	TEVKPVIHSRINLSARFRKPLQEPC	4.0	6.0	-	-	4326_6:24302242-24302242 C>G_TEVKPVIHSRINLSARFRKPLQEPC	0.0
5:137476522-137476522 G>A	0.0	4238	COLORECTAL	-	-	-	-	BRD8	NM_139199,p.R1163C|ENST00000427976,p.R269C|ENST00000254900,p.R1163C|uc003lcf.1,p.R1163C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lcf.1	nonsynonymous SNV	exon26	c.C3487T	p.R1163C	TSLKRNLSKGRIRTMAQFLRDLMLM	TSLKRNLSKGRICTMAQFLRDLMLM	9.0	2.0	-	-	4238_5:137476522-137476522 G>A_TSLKRNLSKGRICTMAQFLRDLMLM	0.0
11:2906560-2906560 T>A	1.0	4316	COLORECTAL	-	-	-	-	CDKN1C	uc001lws.4,p.N54Y|ENST00000414822,p.N54Y|uc001lwu.4,p.N43Y|NM_000076,p.N54Y|ENST00000313407,p.N43Y|uc009ydr.3,p.N43Y|ENST00000430149,p.N54Y|ENST00000440480,p.N43Y|uc001lwr.4,p.N54Y|NM_001122630,p.N43Y|ENST00000380725,p.N43Y|NM_001122631,p.N43Y	retained_intron, protein_coding	uc009ydr.3	nonsynonymous SNV	exon2	c.A127T	p.N43Y	LSRELQARLAELNAEDQNRWDYDFQ	LSRELQARLAELYAEDQNRWDYDFQ	6.0	5.0	-	-	4316_11:2906560-2906560 T>A_LSRELQARLAELYAEDQNRWDYDFQ	0.0
20:5897479-5897479 G>A	0.0	4326	BREAST	-	-	-	-	CHGB	uc002wmg.3,p.R35H|ENST00000455042,p.R15H|NM_001819,p.R35H|ENST00000378961,p.R35H	protein_coding, processed_transcript	uc002wmg.3	nonsynonymous SNV	exon3	c.G104A	p.R35H	VDNRNHNEGMVTRCIIEVLSNALSK	VDNRNHNEGMVTHCIIEVLSNALSK	2.0	5.0	-	-	4326_20:5897479-5897479 G>A_VDNRNHNEGMVTHCIIEVLSNALSK	0.0
9:78953177-78953177 G>C	0.0	4134	NSCLC	-	-	-	-	PCSK5	ENST00000545128,p.E1567Q|NM_001190482,p.E1567Q|uc004akc.2,p.E1567Q|ENST00000424854,p.E1267Q	protein_coding	uc004akc.2	nonsynonymous SNV	exon34	c.G4699C	p.E1567Q	EGYYADNSTGRCERCNRSCKGCQGP	EGYYADNSTGRCQRCNRSCKGCQGP	3.0	10.0	-	-	4134_9:78953177-78953177 G>C_EGYYADNSTGRCQRCNRSCKGCQGP	0.0
1:8424129-8424129 ->G	1.0	4326	BREAST	-	-	-	-	RERE	ENST00000377464,p.R308fs|NM_012102,p.R576fs|NM_001042682,p.R22fs|uc001apd.3,p.R22fs|NM_001042681,p.R576fs|uc001apf.3,p.R576fs|ENST00000476556,p.R22fs|uc001ape.3,p.R576fs|ENST00000337907,p.R576fs|ENST00000400908,p.R576fs|uc010nzx.1,p.R308fs	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc010nzx.1	frameshift insertion	exon9	c.922dupC	p.R308fs	DGLSGKHSMRTRRSRGSMSTLRSGR	DGLSGKHSMRTRPESGLDVDTTQWSEEAASQP	10.0	5.0	-	-	4326_1:8424129-8424129 ->G_DGLSGKHSMRTRPESGLDVDTTQWSEEAASQP	0.0
1:86891129-86891129 ->AGCAAAAT	0.0	4329	COLORECTAL	-	-	-	-	CLCA2	NM_006536,p.N98fs|ENST00000370565,p.N98fs|uc001dlr.4,p.N98fs	protein_coding, processed_transcript	uc001dlr.4	frameshift insertion	exon2	c.294_295insAGCAAAAT	p.N98fs	KILIPATWKANNNSKIKQESYEKAN	KILIPATWKANNNSKIAK	1.0	8.0	-	-	4329_1:86891129-86891129 ->AGCAAAAT_KILIPATWKANNNSKIAK	0.0
11:62652946-62652946 G>A	1.0	4134	NSCLC	-	-	-	-	SLC3A2	ENST00000377890,p.A438T|ENST00000338663,p.A337T|uc001nwf.3,p.A376T|NM_002394,p.A438T|NM_001012664,p.A376T|ENST00000377892,p.A469T|uc001nwd.3,p.A438T|NM_001013251,p.A337T|uc001nwg.3,p.A337T|ENST00000377889,p.A376T|ENST00000377891,p.A439T|ENST00000535296,p.A407T|NM_001012662,p.A439T|uc001nwc.3,p.A439T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001nwg.3	nonsynonymous SNV	exon7	c.G1009A	p.A337T	TGNRWCSWSLSQARLLTSFLPAQLL	TGNRWCSWSLSQTRLLTSFLPAQLL	10.0	3.0	-	-	4134_11:62652946-62652946 G>A_TGNRWCSWSLSQTRLLTSFLPAQLL	0.0
X:73961321-73961321 T>A	0.0	4284	COLORECTAL	-	-	-	-	KIAA2022	ENST00000055682,p.D1024V|NM_001008537,p.D1024V|ENST00000373468,p.D1024V|uc004eby.3,p.D1024V	protein_coding	uc004eby.3	nonsynonymous SNV	exon3	c.A3071T	p.D1024V	KSCEKDGDDDITDDFLAHCSPKLVI	KSCEKDGDDDITVDFLAHCSPKLVI	2.0	6.0	-	-	4284_X:73961321-73961321 T>A_KSCEKDGDDDITVDFLAHCSPKLVI	0.0
6:158576373-158576373 T>C	0.0	3998	MELANOMA	-	-	-	-	SERAC1	uc003qrc.2,p.I34M|ENST00000367101,p.I34M|ENST00000367102,p.I34M|ENST00000607000,p.I34M|NM_032861,p.I34M|ENST00000367104,p.I34M|uc031sqr.1,p.I34M|ENST00000606965,p.I34M	protein_coding	uc031sqr.1	nonsynonymous SNV	exon2	c.A102G	p.I34M	KSGTHWRDIRNIIKFTGSLILGGSL	KSGTHWRDIRNIMKFTGSLILGGSL	5.0	10.0	-	-	3998_6:158576373-158576373 T>C_KSGTHWRDIRNIMKFTGSLILGGSL	0.0
2:201507438-201507438 C>T	1.0	3466	MELANOMA	-	-	-	-	AOX1	uc010fsu.3,p.R287C|uc010zhf.2,p.R477C|ENST00000374700,p.R921C|NM_001159,p.R921C|uc002uvx.3,p.R921C	retained_intron, protein_coding, processed_transcript	uc010zhf.2	nonsynonymous SNV	exon13	c.C1429T	p.R477C	ACRTNLPSNTAFRGFGFPQAALITE	ACRTNLPSNTAFCGFGFPQAALITE	3.0	2.0	-	-	3466_2:201507438-201507438 C>T_ACRTNLPSNTAFCGFGFPQAALITE	0.0
16:55731824-55731824 G>T	0.0	4266	COLORECTAL	-	-	-	-	SLC6A2	ENST00000568943,p.A426S|ENST00000567238,p.A321S|uc021tio.1,p.A426S|ENST00000414754,p.A426S|ENST00000561820,p.A426S|NM_001172504,p.A426S|uc002eii.3,p.A321S|NM_001043,p.A426S|uc002eig.3,p.A426S|uc002eij.3,p.A140S|NM_001172502,p.A321S|uc002eif.3,p.A426S|ENST00000379906,p.A426S|ENST00000219833,p.A426S|NM_001172501,p.A426S|ENST00000566163,p.A381S	protein_coding	uc021tio.1	nonsynonymous SNV	exon9	c.G1276T	p.A426S	ALGLDSSMGGMEAVITGLADDFQVL	ALGLDSSMGGMESVITGLADDFQVL	1.0	9.0	-	-	4266_16:55731824-55731824 G>T_ALGLDSSMGGMESVITGLADDFQVL	0.0
2:197755596-197755596 G>T	1.0	2556	MELANOMA	-	-	-	-	PGAP1	uc002utx.3,p.H203N|uc002utw.3,p.H377N|ENST00000409475,p.H377N|ENST00000354764,p.H377N|NM_024989,p.H377N|ENST00000374738,p.H157N|uc002uty.1,p.H377N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uty.1	nonsynonymous SNV	exon10	c.C1129A	p.H377N	SEKIYFTFPLENHRKIYTHVYCQST	SEKIYFTFPLENNRKIYTHVYCQST	8.0	5.0	-	-	2556_2:197755596-197755596 G>T_SEKIYFTFPLENNRKIYTHVYCQST	0.0
1:94652145-94652145 G>A	1.0	3713	MELANOMA	-	-	-	-	ARHGAP29	ENST00000552844,p.H564Y|NM_004815,p.H564Y|uc001dqj.4,p.H564Y|uc001dqk.3,p.H130Y|ENST00000260526,p.H564Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001dqk.3	nonsynonymous SNV	exon4	c.C388T	p.H130Y	SLDSESISPGDFHRKLPRTPSSGTM	SLDSESISPGDFYRKLPRTPSSGTM	3.0	2.0	-	-	3713_1:94652145-94652145 G>A_SLDSESISPGDFYRKLPRTPSSGTM	0.0
10:135183484-135183484 G>A	1.0	3713	MELANOMA	-	-	-	-	ECHS1	uc001lmu.3,p.S113F|NM_004092,p.S113F|ENST00000368547,p.S113F	protein_coding	uc001lmu.3	nonsynonymous SNV	exon3	c.C338T	p.S113F	KEMQNLSFQDCYSSKFLKHWDHLTQ	KEMQNLSFQDCYFSKFLKHWDHLTQ	6.0	2.0	-	-	3713_10:135183484-135183484 G>A_KEMQNLSFQDCYFSKFLKHWDHLTQ	0.0
11:33667518-33667518 G>A	0.0	4245	COLORECTAL	-	-	-	-	KIAA1549L	ENST00000321505,p.R1602K|NM_012194,p.R1602K|uc021qfs.1,p.R1602K|ENST00000389726,p.R1608K	protein_coding	uc021qfs.1	nonsynonymous SNV	exon16	c.G4805A	p.R1602K	VVTSAPGTMTRPRAGVQWVPTYRPE	VVTSAPGTMTRPKAGVQWVPTYRPE	2.0	4.0	-	-	4245_11:33667518-33667518 G>A_VVTSAPGTMTRPKAGVQWVPTYRPE	0.0
10:60272923-60272923 C>G	1.0	4234	NSCLC	-	-	-	-	BICC1	ENST00000373886,p.P7R|uc001jki.1,p.P7R|NM_001080512,p.P7R	protein_coding, processed_transcript	uc001jki.1	nonsynonymous SNV	exon1	c.C20G	p.P7R	MAAQGEPGYLAAQSDPGSN	MAAQGERGYLAAQSDPGSN	8.0	10.0	-	-	4234_10:60272923-60272923 C>G_MAAQGERGYLAAQSDPGSN	0.0
3:31710272-31710272 C>A	0.0	4317	COLORECTAL	-	-	-	-	OSBPL10	NM_001174060,p.C589F|uc011axf.2,p.C589F|uc021wuu.1,p.C653F|NM_017784,p.C653F|uc003ceu.1,p.C410F|ENST00000438237,p.C589F|ENST00000396556,p.C653F	retained_intron, protein_coding, processed_transcript	uc021wuu.1	nonsynonymous SNV	exon10	c.G1958T	p.C653F	AEVKHNPTNTIVCKAHGEWNGTLEF	AEVKHNPTNTIVFKAHGEWNGTLEF	9.0	3.0	-	-	4317_3:31710272-31710272 C>A_AEVKHNPTNTIVFKAHGEWNGTLEF	0.0
4:6578398-6578398 G>A	0.0	2591	MELANOMA	-	-	-	-	MAN2B2	NM_015274,p.E78K|ENST00000504248,p.E78K|uc011bwf.1,p.E78K|ENST00000285599,p.E78K|NM_001292038,p.E78K|uc003gjf.1,p.E78K|uc003gje.1,p.E78K	protein_coding, processed_transcript	uc011bwf.1	nonsynonymous SNV	exon2	c.G232A	p.E78K	RGQQRRFIAVEQEFFRLWWDGVASD	RGQQRRFIAVEQKFFRLWWDGVASD	6.0	10.0	-	-	2591_4:6578398-6578398 G>A_RGQQRRFIAVEQKFFRLWWDGVASD	0.0
8:94746627-94746627 G>A	1.0	4252	COLORECTAL	-	-	-	-	RBM12B	uc022aye.1,p.P671L|uc003yfz.3,p.P671L|ENST00000399300,p.P671L|NM_203390,p.P671L	protein_coding, processed_transcript	uc022aye.1	nonsynonymous SNV	exon1	c.C2012T	p.P671L	LRWLPEEDFRRPPEEDWRRPPEEDF	LRWLPEEDFRRPLEEDWRRPPEEDF	6.0	7.0	-	-	4252_8:94746627-94746627 G>A_LRWLPEEDFRRPLEEDWRRPPEEDF	0.0
3:120413022-120413022 T>G	1.0	2369	MELANOMA	-	-	-	-	RABL3	ENST00000273375,p.K195T|uc003edx.3,p.K195T|NM_173825,p.K195T	protein_coding, processed_transcript, nonsense_mediated_decay	uc003edx.3	nonsynonymous SNV	exon6	c.A584C	p.K195T	PRYLAAGSSNAVKLSRFFDKVIEKR	PRYLAAGSSNAVTLSRFFDKVIEKR	7.0	5.0	-	-	2369_3:120413022-120413022 T>G_PRYLAAGSSNAVTLSRFFDKVIEKR	0.0
1:16583114-16583117 GTGA>-	1.0	4320	COLORECTAL	-	-	-	-	FBXO42	NM_018994,p.S214fs|ENST00000375592,p.S214fs|uc001ayf.3,p.S121fs|uc001ayg.3,p.S214fs	protein_coding, processed_transcript	uc001ayg.3	frameshift deletion	exon5	c.640_643del	p.S214fs	QPERFFDEIHTYSPSKNWWNCIVTT	QPERFFDEIHTYPLKIGGTAL	6.0	9.0	-	-	4320_1:16583114-16583117 GTGA>-_QPERFFDEIHTYPLKIGGTAL	0.0
22:37271761-37271761 G>A	0.0	2591	MELANOMA	-	-	-	-	NCF4	uc003apz.4,p.E232K|ENST00000248899,p.E232K|NM_013416,p.E232K|ENST00000447071,p.E129K|uc003apy.4,p.E232K|NM_000631,p.E232K|ENST00000397147,p.E232K	protein_coding	uc003apz.4	nonsynonymous SNV	exon8	c.G694A	p.E232K	PLSFVKILKDFPEEDDPTNWLRCYY	PLSFVKILKDFPKEDDPTNWLRCYY	1.0	8.0	-	-	2591_22:37271761-37271761 G>A_PLSFVKILKDFPKEDDPTNWLRCYY	0.0
7:6426892-6426892 C>T	1.0	3879	MELANOMA	-	-	ID=COSM1167878,COSM125734;OCCURENCE=3(NS),1(upper_aerodigestive_tract),1(breast),38(skin),1(endometrium)	1	RAC1	ENST00000356142,p.P29S|NM_018890,p.P29S|uc003spx.3,p.P29S|uc003spw.3,p.P29S|ENST00000348035,p.P29S|NM_006908,p.P29S	retained_intron, protein_coding, processed_transcript	uc003spx.3	nonsynonymous SNV	exon2	c.C85T	p.P29S	TCLLISYTTNAFPGEYIPTVFDNYS	TCLLISYTTNAFSGEYIPTVFDNYS	10.0	2.0	-	-	3879_7:6426892-6426892 C>T_TCLLISYTTNAFSGEYIPTVFDNYS	0.0
5:56179454-56179454 C>T	1.0	4245	COLORECTAL	-	-	-	1	MAP3K1	ENST00000399503,p.S1256F|uc003jqw.4,p.S1256F|NM_005921,p.S1256F	retained_intron, protein_coding	uc003jqw.4	nonsynonymous SNV	exon15	c.C3767T	p.S1256F	LKGQQIGLGAFSSCYQAQDVGTGTL	LKGQQIGLGAFSFCYQAQDVGTGTL	6.0	9.0	-	-	4245_5:56179454-56179454 C>T_LKGQQIGLGAFSFCYQAQDVGTGTL	0.0
21:47552146-47552146 T>G	0.0	4335	COLORECTAL	-	-	-	-	COL6A2	uc002zia.1,p.F914V|NM_001849,p.F914V|ENST00000300527,p.F914V	retained_intron, protein_coding, processed_transcript	uc002zia.1	nonsynonymous SNV	exon28	c.T2740G	p.F914V	HEALETTQYLNSFSHVGAGVVHAIN	HEALETTQYLNSVSHVGAGVVHAIN	10.0	1.0	-	-	4335_21:47552146-47552146 T>G_HEALETTQYLNSVSHVGAGVVHAIN	0.0
20:42635265-42635265 C>G	0.0	4345	COLORECTAL	-	-	-	-	TOX2	uc010ggo.3,p.L82V|ENST00000341197,p.L82V|ENST00000423191,p.L40V|ENST00000442881,p.L40V|ENST00000358131,p.L91V|NM_032883,p.L40V|NM_001098798,p.L91V|NM_001098797,p.L82V|uc021wdz.2,p.L82V|NM_001098796,p.L40V|uc002xlf.4,p.L91V|uc002xle.4,p.L40V|uc010ggp.3,p.L40V|ENST00000372999,p.L40V	protein_coding	uc021wdz.2	nonsynonymous SNV	exon3	c.C244G	p.L82V	PPITPPNLPEPSLLHLGDHEASYHS	PPITPPNLPEPSVLHLGDHEASYHS	5.0	3.0	-	-	4345_20:42635265-42635265 C>G_PPITPPNLPEPSVLHLGDHEASYHS	0.0
2:214182043-214182043 T>G	1.0	4196	COLORECTAL	-	-	-	-	SPAG16	uc002ver.4,p.L113V|uc002veq.4,p.L167V|NM_024532,p.L167V|uc002ves.1,p.L136V|ENST00000374309,p.L73V|ENST00000331683,p.L167V|ENST00000447990,p.L167V|ENST00000272898,p.L167V|uc010zjk.3,p.L73V|ENST00000413312,p.L136V	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zjk.3	nonsynonymous SNV	exon4	c.T217G	p.L73V	TQIMLLENENKNLKKDLKHYKQAAD	TQIMLLENENKNVKKDLKHYKQAAD	7.0	3.0	-	-	4196_2:214182043-214182043 T>G_TQIMLLENENKNVKKDLKHYKQAAD	0.0
12:91502710-91502710 G>T	0.0	4252	COLORECTAL	-	-	-	-	LUM	NM_002345,p.T16N|ENST00000266718,p.T16N|uc001tbm.3,p.T16N	protein_coding, processed_transcript	uc001tbm.3	nonsynonymous SNV	exon2	c.C47A	p.T16N	SAFTLFLALIGGTSGQYYDYDFPLS	SAFTLFLALIGGNSGQYYDYDFPLS	10.0	9.0	-	-	4252_12:91502710-91502710 G>T_SAFTLFLALIGGNSGQYYDYDFPLS	0.0
Y:22923182-22923182 T>C	0.0	4275	COLORECTAL	-	-	-	-	RPS4Y2	ENST00000288666,p.I92T|uc011nbb.2,p.I92T|NM_001039567,p.I92T	protein_coding	uc011nbb.2	nonsynonymous SNV	exon4	c.T275C	p.I92T	ITYPAGFIDVISIEKTGEHFRLVYN	ITYPAGFIDVISTEKTGEHFRLVYN	2.0	10.0	-	-	4275_Y:22923182-22923182 T>C_ITYPAGFIDVISTEKTGEHFRLVYN	0.0
7:91632448-91632448 G>A	0.0	4335	COLORECTAL	-	-	-	2	AKAP9	uc003ulg.3,p.D1073N|NM_147185,p.D1073N|ENST00000358100,p.D1085N|uc003ulf.3,p.D1073N|NM_005751,p.D1073N|uc003uli.3,p.D698N|uc003ule.2,p.D1085N|ENST00000356239,p.D1073N|ENST00000359028,p.D1085N	retained_intron, protein_coding, processed_transcript	uc003uli.3	nonsynonymous SNV	exon1	c.G2092A	p.D698N	VGEESKQEQLILDHLPSVTKESSLR	VGEESKQEQLILNHLPSVTKESSLR	9.0	9.0	-	-	4335_7:91632448-91632448 G>A_VGEESKQEQLILNHLPSVTKESSLR	0.0
11:69488012-69488012 G>A	1.0	4287	COLORECTAL	-	-	-	-	ORAOV1	uc001ope.1,p.T43M|ENST00000279147,p.T43M|ENST00000535657,p.T43M|ENST00000538554,p.T43M|NM_153451,p.T43M|ENST00000542341,p.T43M|ENST00000539414,p.T43M|uc001opc.3,p.T43M|uc010rqi.1,p.T43M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rqi.1	nonsynonymous SNV	exon2	c.C128T	p.T43M	SSLGVMEGRQHGTLHGAKIGSEIGC	SSLGVMEGRQHGMLHGAKIGSEIGC	6.0	9.0	-	-	4287_11:69488012-69488012 G>A_SSLGVMEGRQHGMLHGAKIGSEIGC	0.0
1:197160876-197160876 G>A	1.0	3998	MELANOMA	-	-	-	-	ZBTB41	uc001gtx.1,p.P425L|ENST00000367405,p.P425L|NM_194314,p.P425L	protein_coding, processed_transcript	uc001gtx.1	nonsynonymous SNV	exon2	c.C1274T	p.P425L	NETEFHKKEHKCPYCNKLHASKKTL	NETEFHKKEHKCLYCNKLHASKKTL	8.0	4.0	-	-	3998_1:197160876-197160876 G>A_NETEFHKKEHKCLYCNKLHASKKTL	0.0
1:236897795-236897795 C>T	0.0	3795	MELANOMA	-	-	-	-	ACTN2	ENST00000542672,p.H254Y|uc009xgi.1,p.H254Y|uc010pxu.1,p.H39Y|NM_001278343,p.H254Y	protein_coding, processed_transcript	uc010pxu.1	nonsynonymous SNV	exon2	c.C115T	p.H39Y	ERAIMTYVSCYYHAFAGAQKAETAA	ERAIMTYVSCYYYAFAGAQKAETAA	6.0	7.0	-	-	3795_1:236897795-236897795 C>T_ERAIMTYVSCYYYAFAGAQKAETAA	0.0
20:62325827-62325827 G>A	1.0	4155	MELANOMA	-	-	-	-	RTEL1	ENST00000482936,p.R1032K|uc011abe.1,p.R809K|NM_032957,p.R1056K|ENST00000370003,p.R277K|NM_001283009,p.R1032K|ENST00000360203,p.R1032K|uc002yfu.2,p.R1032K|NM_001283010,p.R809K|uc011abd.2,p.R1056K|ENST00000318100,p.R1032K|ENST00000508582,p.R1056K|ENST00000370018,p.R1032K|uc002yfx.1,p.R277K|NM_016434,p.R1032K	 processed_transcript,protein_coding, nonsense_mediated_decay	uc011abe.1	nonsynonymous SNV	exon30	c.G2426A	p.R809K	EHLNQGRPHLSPRPPPTGDPGSQPQ	EHLNQGRPHLSPKPPPTGDPGSQPQ	7.0	3.0	-	-	4155_20:62325827-62325827 G>A_EHLNQGRPHLSPKPPPTGDPGSQPQ	0.0
19:53554077-53554077 A>G	0.0	4246	COLORECTAL	-	-	-	-	ERVV-2	uc031rmt.1,p.R525G|NM_001191055,p.R525G|ENST00000601417,p.R525G|uc021uzd.1,p.R525G	protein_coding	uc031rmt.1	nonsynonymous SNV	exon1	c.A1573G	p.R525G	YKHISPLDASGQRFRETMEEFSL	YKHISPLDASGQGFRETMEEFSL	1.0	3.0	-	-	4246_19:53554077-53554077 A>G_YKHISPLDASGQGFRETMEEFSL	0.0
7:100417235-100417235 G>A	1.0	4000	MELANOMA	-	-	-	-	EPHB4	uc003uwm.1,p.S321F|ENST00000360620,p.S414F|NM_004444,p.S414F|uc010lhj.1,p.S414F|uc011kkf.1,p.S414F|uc003uwn.1,p.S414F|ENST00000358173,p.S414F	retained_intron, protein_coding, processed_transcript	uc011kkf.1	nonsynonymous SNV	exon6	c.C1241T	p.S414F	YTFEVTALNGVSSLATGPVPFEPVN	YTFEVTALNGVSFLATGPVPFEPVN	8.0	6.0	-	-	4000_7:100417235-100417235 G>A_YTFEVTALNGVSFLATGPVPFEPVN	0.0
20:377195-377195 C>T	1.0	3713	MELANOMA	-	-	-	-	TRIB3	NM_001301193,p.P313L|NM_021158,p.P313L|uc002wdn.3,p.P340L|NM_001301201,p.P340L|NM_001301188,p.P313L|ENST00000422053,p.P340L|uc002wdm.3,p.P313L|NM_001301190,p.P313L|ENST00000217233,p.P313L|NM_001301196,p.P313L	protein_coding, processed_transcript	uc002wdn.3	nonsynonymous SNV	exon5	c.C1019T	p.P340L	AERLTATGILLHPWLRQDPMPLAPT	AERLTATGILLHLWLRQDPMPLAPT	6.0	5.0	-	-	3713_20:377195-377195 C>T_AERLTATGILLHLWLRQDPMPLAPT	0.0
8:27312126-27312126 G>A	0.0	2556	MELANOMA	-	-	ID=COSM131805;OCCURENCE=1(skin)	-	PTK2B	uc022ate.1,p.E938K|NM_004103,p.E938K|ENST00000338238,p.E896K|ENST00000544172,p.E938K|ENST00000517339,p.E896K|ENST00000346049,p.E938K|uc003xfn.2,p.E938K|NM_173175,p.E896K|ENST00000420218,p.E896K|ENST00000397501,p.E938K|NM_173174,p.E938K|uc003xfq.2,p.E896K|NM_173176,p.E938K|uc003xfp.2,p.E938K	retained_intron, protein_coding, processed_transcript	uc022ate.1	nonsynonymous SNV	exon31	c.G2812A	p.E938K	DLLPSLPSSSRTEIEGTQKLLNKDL	DLLPSLPSSSRTKIEGTQKLLNKDL	5.0	2.0	-	-	2556_8:27312126-27312126 G>A_DLLPSLPSSSRTKIEGTQKLLNKDL	0.0
18:6138202-6138202 C>T	1.0	2556	MELANOMA	-	-	-	-	L3MBTL4	uc010dkt.3,p.G397E|ENST00000535782,p.G210E|ENST00000317931,p.G397E|ENST00000400104,p.G397E|uc002kmz.4,p.G397E|NM_173464,p.G397E|ENST00000400105,p.G397E|uc002kmy.4,p.G397E|ENST00000284898,p.G397E	protein_coding, processed_transcript	uc010dkt.3	nonsynonymous SNV	exon14	c.G1190A	p.G397E	RGIGHIRGPRYSGHHSAFGCPYSDM	RGIGHIRGPRYSEHHSAFGCPYSDM	5.0	1.0	-	-	2556_18:6138202-6138202 C>T_RGIGHIRGPRYSEHHSAFGCPYSDM	0.0
1:158639560-158639560 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	SPTA1	uc001fst.1,p.A539E|ENST00000368147,p.A539E|NM_003126,p.A539E|ENST00000368148,p.A539E	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon13	c.C1616A	p.A539E	AQEEKIITVDKTATKLIGDDHYDSE	AQEEKIITVDKTETKLIGDDHYDSE	2.0	8.0	-	-	4258_1:158639560-158639560 G>T_AQEEKIITVDKTETKLIGDDHYDSE	0.0
17:39324124-39324124 G>A	0.0	4196	COLORECTAL	-	-	-	-	KRTAP4-3	NM_033187,p.R101C|ENST00000391356,p.R101C|uc010cxl.3,p.R101C	protein_coding	uc010cxl.3	nonsynonymous SNV	exon1	c.C301T	p.R101C	CCKPSCCRTTCCRPSCCISSCCRPS	CCKPSCCRTTCCCPSCCISSCCRPS	2.0	5.0	-	-	4196_17:39324124-39324124 G>A_CCKPSCCRTTCCCPSCCISSCCRPS	0.0
6:30609962-30609962 G>A	1.0	4189	MELANOMA	-	-	-	-	ATAT1	NM_024909,p.R221K|uc003rdc.3,p.R221K|uc003nqr.4,p.R221K|NM_001031722,p.R209K|ENST00000329992,p.R221K|ENST00000330083,p.R209K|ENST00000376483,p.R221K|ENST00000376485,p.R221K|uc003nqv.3,p.R209K	retained_intron, protein_coding, processed_transcript	uc003rdc.3	nonsynonymous SNV	exon9	c.G662A	p.R221K	AAAVDPTPAAPARKLPPKRAEGDIK	AAAVDPTPAAPAKKLPPKRAEGDIK	7.0	4.0	-	-	4189_6:30609962-30609962 G>A_AAAVDPTPAAPAKKLPPKRAEGDIK	0.0
7:92761164-92761164 T>G	1.0	3713	MELANOMA	-	-	-	-	SAMD9L	ENST00000437805,p.K1374T|uc022ahh.1,p.K1374T|NM_152703,p.K1374T|ENST00000318238,p.K1374T|uc010lfd.1,p.K1374T|uc003umi.1,p.K1374T|uc003umj.1,p.K1374T|ENST00000411955,p.K1374T|uc010lfb.1,p.K1374T|uc010lfc.1,p.K1374T|uc003umh.1,p.K1374T|uc003umk.1,p.K1374T	protein_coding, processed_transcript	uc022ahh.1	nonsynonymous SNV	exon1	c.A4121C	p.K1374T	NEYAFLLQQNSKKPMTNEKQNSILA	NEYAFLLQQNSKTPMTNEKQNSILA	9.0	9.0	-	-	3713_7:92761164-92761164 T>G_NEYAFLLQQNSKTPMTNEKQNSILA	0.0
11:64025995-64025995 C>A	1.0	4046	OVARIAN	-	-	-	-	PLCB3	ENST00000540288,p.L355I|ENST00000279230,p.L355I|uc009ypg.2,p.L355I|uc009yph.2,p.L288I|NM_001184883,p.L288I|uc009ypi.3,p.L355I|NM_000932,p.L355I|ENST00000325234,p.L288I	retained_intron, protein_coding	uc009ypi.3	nonsynonymous SNV	exon11	c.C1063A	p.L355I	GTSSVEMYRQALLWGCRCVELDVWK	GTSSVEMYRQALIWGCRCVELDVWK	8.0	6.0	-	-	4046_11:64025995-64025995 C>A_GTSSVEMYRQALIWGCRCVELDVWK	0.0
17:37234201-37234201 G>A	0.0	3775	CERVICAL	-	-	-	-	PLXDC1	ENST00000315392,p.S384F|NM_020405,p.S384F|uc002hrg.2,p.S384F|ENST00000444911,p.S344F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002hrg.2	nonsynonymous SNV	exon11	c.C1151T	p.S384F	SFSPYDGDLTTTSSSLFIDSLTTED	SFSPYDGDLTTTFSSLFIDSLTTED	8.0	8.0	-	-	3775_17:37234201-37234201 G>A_SFSPYDGDLTTTFSSLFIDSLTTED	0.0
10:83637750-83637750 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM1474824;OCCURENCE=1(breast)	-	NRG3	ENST00000602794,p.V12I	protein_coding, nonsense_mediated_decay	ENST00000602794	nonsynonymous SNV	exon1	c.G34A	p.V12I	MECGIPPTLVCVGRGGGLHTVFQR	MECGIPPTLVCIGRGGGLHTVFQR	3.0	1.0	-	-	4284_10:83637750-83637750 G>A_MECGIPPTLVCIGRGGGLHTVFQR	0.0
16:48149423-48149423 G>A	0.0	3903	MELANOMA	-	-	-	-	ABCC12	uc002efc.1,p.S631L|ENST00000529504,p.S631L|NM_033226,p.S631L|ENST00000311303,p.S631L|ENST00000532494,p.S631L|ENST00000534418,p.S573L|ENST00000497206,p.S631L|ENST00000448542,p.S631L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002efc.1	nonsynonymous SNV	exon13	c.C1892T	p.S631L	SDRQLYLLDDPLSAVDAHVGKHVFE	SDRQLYLLDDPLLAVDAHVGKHVFE	1.0	6.0	-	-	3903_16:48149423-48149423 G>A_SDRQLYLLDDPLLAVDAHVGKHVFE	0.0
7:98591251-98591251 G>A	1.0	4244	COLORECTAL	-	-	ID=COSM1093709,COSM20429;OCCURENCE=1(endometrium),1(large_intestine)	1	TRRAP	uc011kis.2,p.R3270H|uc003upp.3,p.R3299H|uc003upr.3,p.R3005H|NM_003496,p.R3270H|ENST00000355540,p.R3270H|NM_001244580,p.R3299H|ENST00000359863,p.R3299H|ENST00000446306,p.R3288H	retained_intron, protein_coding	uc011kis.2	nonsynonymous SNV	exon64	c.G9809A	p.R3270H	DPGPIRATAPMWRCSRIMHMQRELH	DPGPIRATAPMWHCSRIMHMQRELH	6.0	10.0	-	-	4244_7:98591251-98591251 G>A_DPGPIRATAPMWHCSRIMHMQRELH	0.0
12:110029130-110029130 G>A	1.0	4252	COLORECTAL	-	-	-	-	MVK	uc009zvk.3,p.A285T|ENST00000541384,p.A91T|uc010sxr.2,p.A233T|ENST00000539575,p.A233T|ENST00000228510,p.A285T|ENST00000392727,p.A233T|uc001toy.4,p.A285T|NM_001114185,p.A285T|NM_000431,p.A285T|uc001toz.4,p.A91T|NM_001301182,p.A233T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sxr.2	nonsynonymous SNV	exon8	c.G697A	p.A233T	LECERVLGEMGEAPAPEQYLVLEEL	LECERVLGEMGETPAPEQYLVLEEL	9.0	10.0	-	-	4252_12:110029130-110029130 G>A_LECERVLGEMGETPAPEQYLVLEEL	0.0
12:31600513-31600513 C>T	1.0	4316	COLORECTAL	-	-	ID=COSM185361;OCCURENCE=1(large_intestine)	-	DENND5B	ENST00000354285,p.R629Q|ENST00000306833,p.R642Q|NM_144973,p.R607Q|uc001rkh.1,p.R642Q|uc001rkj.3,p.R629Q|ENST00000389082,p.R607Q|ENST00000536562,p.R642Q|uc001rki.1,p.R607Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rkj.3	nonsynonymous SNV	exon7	c.G1886A	p.R629Q	KIRLYNVRAPTLRTSIYQKCSTLKE	KIRLYNVRAPTLQTSIYQKCSTLKE	5.0	9.0	-	-	4316_12:31600513-31600513 C>T_KIRLYNVRAPTLQTSIYQKCSTLKE	0.0
1:155491162-155491162 C>T	1.0	4320	COLORECTAL	-	-	-	-	ASH1L	uc009wqq.3,p.R50H|ENST00000392403,p.R50H|ENST00000548830,p.R50H|NM_018489,p.R50H|ENST00000368346,p.R50H|uc009wqr.1,p.R50H|uc001fkt.3,p.R50H	retained_intron, protein_coding, nonsense_mediated_decay	uc009wqr.1	nonsynonymous SNV	exon3	c.G149A	p.R50H	ELEKNTKEEEDLRKRNRERNIEAGK	ELEKNTKEEEDLHKRNRERNIEAGK	8.0	9.0	-	-	4320_1:155491162-155491162 C>T_ELEKNTKEEEDLHKRNRERNIEAGK	0.0
9:136280096-136280096 C>G	0.0	4298	COLORECTAL	-	-	-	-	REXO4	uc004cdm.3,p.K87N|ENST00000371942,p.K87N|ENST00000453165,p.K72N|NM_020385,p.K87N	protein_coding, processed_transcript	uc004cdm.3	nonsynonymous SNV	exon2	c.G261C	p.K87N	EWLLKQKSQAPEKPLVISQMGSKKK	EWLLKQKSQAPENPLVISQMGSKKK	8.0	2.0	-	-	4298_9:136280096-136280096 C>G_EWLLKQKSQAPENPLVISQMGSKKK	0.0
12:109614037-109614037 G>C	1.0	4335	COLORECTAL	-	-	-	-	ACACB	ENST00000377848,p.S469T|uc001toc.3,p.S469T|ENST00000377854,p.S469T|ENST00000338432,p.S469T|uc001tob.3,p.S469T|NM_001093,p.S469T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001toc.3	nonsynonymous SNV	exon8	c.G1406C	p.S469T	EGGGGKGIRKAESAEDFPILFRQVQ	EGGGGKGIRKAETAEDFPILFRQVQ	10.0	9.0	-	-	4335_12:109614037-109614037 G>C_EGGGGKGIRKAETAEDFPILFRQVQ	0.0
1:177906522-177906522 G>A	1.0	2556	MELANOMA	-	-	-	-	SEC16B	uc001glk.1,p.P454L|NM_033127,p.P777L|ENST00000308284,p.P777L|uc001gli.1,p.P777L|uc001glh.1,p.P436L|uc001glj.1,p.P778L|uc009wwz.1,p.P436L|uc009wwy.1,p.P332L	retained_intron, protein_coding, processed_transcript	uc009wwz.1	nonsynonymous SNV	exon18	c.C1307T	p.P436L	TCLLQPSPQQPFPLQPGSYPAGGGA	TCLLQPSPQQPFLLQPGSYPAGGGA	4.0	8.0	-	-	2556_1:177906522-177906522 G>A_TCLLQPSPQQPFLLQPGSYPAGGGA	0.0
20:3251129-3251129 G>C	1.0	4069	PANCREATIC	-	-	-	-	C20orf194	uc002wii.3,p.I910M|uc002wik.2,p.I584M|NM_001009984,p.I910M|ENST00000252032,p.I910M|uc002wij.3,p.I649M	protein_coding, processed_transcript	uc002wik.2	nonsynonymous SNV	exon25	c.C1752G	p.I584M	QRHPLLVQLQSLIRAANPAAAFILA	QRHPLLVQLQSLMRAANPAAAFILA	7.0	8.0	-	-	4069_20:3251129-3251129 G>C_QRHPLLVQLQSLMRAANPAAAFILA	0.0
19:21606900-21606900 G>T	0.0	4326	BREAST	-	-	-	-	ZNF493	uc021urq.1,p.R352M|uc002npx.3,p.R352M|uc002npw.3,p.R480M|uc002npy.3,p.R352M|NM_175910,p.R352M|ENST00000355504,p.R352M|NM_001076678,p.R480M|ENST00000392288,p.R480M	retained_intron, protein_coding, nonsense_mediated_decay	uc021urq.1	nonsynonymous SNV	exon1	c.G1055T	p.R352M	KAFKRSSTLTKHRIIHTEEKPYKCE	KAFKRSSTLTKHMIIHTEEKPYKCE	10.0	6.0	-	-	4326_19:21606900-21606900 G>T_KAFKRSSTLTKHMIIHTEEKPYKCE	0.0
14:104407890-104407890 A>T	0.0	4266	COLORECTAL	-	-	-	-	RD3L	uc031qqp.1,p.I48N|NM_001257268,p.I48N|ENST00000557640,p.I48N|ENST00000455348,p.I48N	protein_coding	uc031qqp.1	nonsynonymous SNV	exon2	c.T143A	p.I48N	WHLKERERLIQEIENEQKVKKTGVD	WHLKERERLIQENENEQKVKKTGVD	3.0	5.0	-	-	4266_14:104407890-104407890 A>T_WHLKERERLIQENENEQKVKKTGVD	0.0
X:102192922-102192922 T>A	1.0	4317	COLORECTAL	-	-	-	-	RAB40AL	ENST00000218249,p.S226T|NM_001031834,p.S226T|uc004ejs.3,p.S226T	protein_coding	uc004ejs.3	nonsynonymous SNV	exon1	c.T676A	p.S226T	LPIALRSHLKSFSMAKGLNARMMRG	LPIALRSHLKSFTMAKGLNARMMRG	6.0	4.0	-	-	4317_X:102192922-102192922 T>A_LPIALRSHLKSFTMAKGLNARMMRG	0.0
3:122942526-122942526 G>A	0.0	4081	COLORECTAL	-	-	-	-	SEC22A	NM_012430,p.M101I|ENST00000473494,p.M101I|uc003egf.3,p.M101I|ENST00000487572,p.M101I|uc003ege.3,p.M101I|ENST00000480631,p.M101I|ENST00000492595,p.M101I|ENST00000309934,p.M101I	protein_coding, processed_transcript, nonsense_mediated_decay	uc003egf.3	nonsynonymous SNV	exon2	c.G303A	p.M101I	ELQKEFITTYNMMKTNTAVRPYCFI	ELQKEFITTYNMIKTNTAVRPYCFI	4.0	7.0	-	-	4081_3:122942526-122942526 G>A_ELQKEFITTYNMIKTNTAVRPYCFI	0.0
15:49135772-49135772 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	SHC4	ENST00000557797,p.Q133L	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000557797	nonsynonymous SNV	exon6	c.A398T	p.Q133L	QCEKLCYLVMSIQEGCSPSEIPHY	QCEKLCYLVMSILEGCSPSEIPHY	2.0	3.0	-	-	4258_15:49135772-49135772 T>A_QCEKLCYLVMSILEGCSPSEIPHY	0.0
15:28436305-28436305 G>C	1.0	4110	BILE DUCT	-	-	-	-	HERC2	NM_004667,p.P2846R|ENST00000261609,p.P2846R|uc001zbj.4,p.P2846R|uc001zbk.1,p.P381R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001zbk.1	nonsynonymous SNV	exon9	c.C1142G	p.P381R	KMIVDPADSSYMPSLVVVSGGNSLN	KMIVDPADSSYMRSLVVVSGGNSLN	7.0	9.0	-	-	4110_15:28436305-28436305 G>C_KMIVDPADSSYMRSLVVVSGGNSLN	0.0
16:82104663-82104663 G>A	0.0	2591	MELANOMA	-	-	-	-	HSD17B2	ENST00000199936,p.V199I|ENST00000566838,p.V75I|NM_002153,p.V199I|ENST00000569351,p.V127I|uc002fgv.3,p.V199I|ENST00000568090,p.V63I	protein_coding, TEC	uc002fgv.3	nonsynonymous SNV	exon3	c.G595A	p.V199I	QCMAVNFFGTVEVTKTFLPLLRKSK	QCMAVNFFGTVEITKTFLPLLRKSK	1.0	2.0	-	-	2591_16:82104663-82104663 G>A_QCMAVNFFGTVEITKTFLPLLRKSK	0.0
16:4463368-4463368 G>A	1.0	3678	MELANOMA	-	-	-	-	CORO7,CORO7-PAM16	NM_001201473,p.S33L|NM_001201472,p.S33L|uc010uxi.2,p.S33L|NM_001201479,p.S33L|ENST00000574025,p.S33L|uc002cwh.4,p.S33L|ENST00000572898,p.S33L|ENST00000572467,p.S33L|ENST00000571059,p.S33L|ENST00000537233,p.S33L|ENST00000251166,p.S33L|NM_024535,p.S33L|ENST00000571756,p.S33L|uc002cwf.3,p.S33L|ENST00000570928,p.S33L|ENST00000575850,p.S46L|uc010uxh.2,p.S33L|ENST00000575038,p.S33L|ENST00000575334,p.S33L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uxi.2	nonsynonymous SNV	exon2	c.C98T	p.S33L	SWISDIRAGTAPSCRNHIKSSCSLI	SWISDIRAGTAPLCRNHIKSSCSLI	8.0	3.0	CD8	-	3678_16:4463368-4463368 G>A_SWISDIRAGTAPLCRNHIKSSCSLI	1.0
6:33254984-33254984 G>A	1.0	3713	MELANOMA	-	-	-	-	WDR46	uc011dra.2,p.T246I|uc003ods.3,p.T300I|NM_005452,p.T300I|ENST00000444176,p.T227I|ENST00000374617,p.T300I|NM_001164267,p.T246I	retained_intron, protein_coding, processed_transcript	uc011dra.2	nonsynonymous SNV	exon9	c.C737T	p.T246I	FLLATASETGFLTYLDVSVGKIVAA	FLLATASETGFLIYLDVSVGKIVAA	8.0	3.0	CD8	-	3713_6:33254984-33254984 G>A_FLLATASETGFLIYLDVSVGKIVAA	1.0
X:99551676-99551676 C>T	0.0	4252	COLORECTAL	-	-	-	-	PCDH19	NM_001105243,p.A969T|ENST00000420881,p.A968T|ENST00000255531,p.A969T|NM_020766,p.A968T|uc004efw.4,p.A968T|ENST00000373034,p.A1016T|NM_001184880,p.A1016T|uc010nmz.3,p.A1016T|uc004efx.4,p.A969T	protein_coding, processed_transcript	uc010nmz.3	nonsynonymous SNV	exon6	c.G3046A	p.A1016T	AYDDCGPTKRTFATFGKDVSDHPAE	AYDDCGPTKRTFTTFGKDVSDHPAE	3.0	10.0	-	-	4252_X:99551676-99551676 C>T_AYDDCGPTKRTFTTFGKDVSDHPAE	0.0
6:40400092-40400092 C>A	0.0	4298	COLORECTAL	-	-	-	-	LRFN2	ENST00000338305,p.R254L|uc003oph.1,p.R254L|NM_020737,p.R254L	protein_coding	uc003oph.1	nonsynonymous SNV	exon2	c.G761T	p.R254L	NPLHCNCELLWLRRLERDDDLETCG	NPLHCNCELLWLLRLERDDDLETCG	2.0	8.0	-	-	4298_6:40400092-40400092 C>A_NPLHCNCELLWLLRLERDDDLETCG	0.0
15:65242092-65242092 G>A	1.0	4189	MELANOMA	0.0	-	-	-	ANKDD1A	ENST00000395723,p.R338Q|ENST00000487867,p.R370Q|uc002aoa.3,p.R461Q|NM_182703,p.R461Q|ENST00000380230,p.R461Q|ENST00000357698,p.R429Q|ENST00000395720,p.R461Q|uc010bha.3,p.R338Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bha.3	nonsynonymous SNV	exon10	c.G1013A	p.R338Q	WTGTRSYQEHGHRMLLIWLHGVATA	WTGTRSYQEHGHQMLLIWLHGVATA	5.0	2.0	-	-	4189_15:65242092-65242092 G>A_WTGTRSYQEHGHQMLLIWLHGVATA	0.0
17:28323378-28323378 G>A	0.0	3903	MELANOMA	-	-	-	-	EFCAB5	uc002het.3,p.G325R|uc010wbj.2,p.G269R|uc010cse.3,p.G204R|NM_001145053,p.G269R|uc010csf.3,p.G204R|NM_198529,p.G325R|uc010wbi.1,p.G68R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wbj.2	nonsynonymous SNV	exon6	c.G805A	p.G269R	LQEFFQNPDFKLGSHCKQLDITDST	LQEFFQNPDFKLRSHCKQLDITDST	4.0	1.0	-	-	3903_17:28323378-28323378 G>A_LQEFFQNPDFKLRSHCKQLDITDST	0.0
7:77797313-77797313 C>T	0.0	4129	NSCLC	-	-	-	-	MAGI2	uc010ldx.1,p.R432H|ENST00000522391,p.R839H|uc003ugy.3,p.R825H|NM_001301128,p.R825H|ENST00000354212,p.R839H|uc003ugx.3,p.R839H|NM_012301,p.R839H|ENST00000419488,p.R825H	retained_intron, protein_coding, processed_transcript	uc010ldx.1	nonsynonymous SNV	exon10	c.G1295A	p.R432H	YVDGIPVAGKTHRYVIDLMHHAARN	YVDGIPVAGKTHHYVIDLMHHAARN	3.0	8.0	-	-	4129_7:77797313-77797313 C>T_YVDGIPVAGKTHHYVIDLMHHAARN	0.0
5:39202072-39202072 C>T	1.0	3879	MELANOMA	-	-	-	-	FYB	uc003jlu.3,p.E331K|uc003jlt.3,p.E331K|ENST00000512982,p.E331K|ENST00000515010,p.E331K|ENST00000540520,p.E341K|ENST00000505428,p.E331K|uc003jls.3,p.E331K|NM_001243093,p.E341K|NM_001465,p.E331K|NM_199335,p.E331K|ENST00000351578,p.E331K|uc011cpl.2,p.E341K	protein_coding, processed_transcript	uc011cpl.2	nonsynonymous SNV	exon2	c.G1021A	p.E341K	KLTVGGPWGQSQEKEKGDKNSATPK	KLTVGGPWGQSQKKEKGDKNSATPK	5.0	8.0	-	-	3879_5:39202072-39202072 C>T_KLTVGGPWGQSQKKEKGDKNSATPK	0.0
17:19559841-19559841 A>C	1.0	4071	COLORECTAL	-	-	-	-	ALDH3A2	ENST00000571537,p.S43R|ENST00000581518,p.S212R|ENST00000579855,p.S212R|NM_001031806,p.S212R|NM_000382,p.S212R|ENST00000582991,p.S212R|uc002gwb.1,p.S212R|uc010cqr.1,p.S19R|uc002gwa.1,p.S212R|ENST00000176643,p.S212R|ENST00000395575,p.S212R|uc002gwd.1,p.S19R|ENST00000339618,p.S212R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cqr.1	nonsynonymous SNV	exon5	c.A55C	p.S19R	HLTPVTLELGGKSPCYIDKDCDLDI	HLTPVTLELGGKRPCYIDKDCDLDI	9.0	5.0	-	-	4071_17:19559841-19559841 A>C_HLTPVTLELGGKRPCYIDKDCDLDI	0.0
1:16058923-16058923 C>T	1.0	2369	MELANOMA	-	-	-	-	PLEKHM2	ENST00000375799,p.H902Y|NM_015164,p.H902Y|uc010obo.2,p.H902Y|ENST00000375793,p.H882Y	protein_coding, processed_transcript	uc010obo.2	nonsynonymous SNV	exon18	c.C2704T	p.H902Y	CLVLTDDRLFTCHEDCQTSFFRSLG	CLVLTDDRLFTCYEDCQTSFFRSLG	9.0	4.0	CD8	-	2369_1:16058923-16058923 C>T_CLVLTDDRLFTCYEDCQTSFFRSLG	1.0
14:74360572-74360572 A>-	1.0	4345	COLORECTAL	-	-	-	-	ZNF410	ENST00000540593,p.I36fs|uc001xoz.2,p.I36fs|uc010arz.2,p.I36fs|ENST00000555044,p.I36fs|ENST00000398139,p.I36fs|ENST00000324593,p.I36fs|NM_021188,p.I36fs|NM_001242927,p.I36fs|uc001xpb.2,p.I36fs|ENST00000557495,p.I43fs|ENST00000556396,p.I36fs|ENST00000556160,p.I36fs|ENST00000554797,p.I36fs|ENST00000442160,p.I36fs|ENST00000554582,p.I36fs|NM_001242924,p.I36fs|uc010tuh.2,p.I36fs|ENST00000556659,p.I36fs|NM_001242926,p.I36fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tuh.2	frameshift deletion	exon3	c.106delA	p.I36fs	LGQGLVESEAKDITCLSLLPVTEASE	LGQGLVESEAKDLLACPSFP	9.0	3.0	-	-	4345_14:74360572-74360572 A>-_LGQGLVESEAKDLLACPSFP	0.0
4:156784892-156784892 T>A	0.0	4346	COLORECTAL	-	-	-	-	ASIC5	NM_017419,p.I19L|ENST00000537611,p.I19L|uc003ipe.1,p.I19L	protein_coding	uc003ipe.1	nonsynonymous SNV	exon2	c.A55T	p.I19L	SKVYAENGLLEKIKLCLSKKPLPSP	SKVYAENGLLEKLKLCLSKKPLPSP	1.0	7.0	-	-	4346_4:156784892-156784892 T>A_SKVYAENGLLEKLKLCLSKKPLPSP	0.0
X:120182697-120182697 C>A	0.0	4110	BILE DUCT	-	-	-	-	GLUD2	uc004eto.3,p.Q387K|ENST00000328078,p.Q387K|NM_012084,p.Q387K	protein_coding	uc004eto.3	nonsynonymous SNV	exon1	c.C1159A	p.Q387K	DCDILIPAATEKQLTKSNAPRVKAK	DCDILIPAATEKKLTKSNAPRVKAK	7.0	10.0	-	-	4110_X:120182697-120182697 C>A_DCDILIPAATEKKLTKSNAPRVKAK	0.0
5:169494666-169494666 G>A	0.0	3919	MELANOMA	-	-	-	-	DOCK2	ENST00000256935,p.M1540I|uc003mah.3,p.M96I|NM_004946,p.M1540I|ENST00000540750,p.M601I|uc010jjm.3,p.M1032I|ENST00000520908,p.M1032I|uc003maf.3,p.M1540I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jjm.3	nonsynonymous SNV	exon31	c.G3096A	p.M1032I	SMLLNGIVDPAVMGGFAKYEKAFFT	SMLLNGIVDPAVIGGFAKYEKAFFT	3.0	10.0	-	-	3919_5:169494666-169494666 G>A_SMLLNGIVDPAVIGGFAKYEKAFFT	0.0
5:140481191-140481191 G>A	0.0	4095	COLORECTAL	-	-	-	-	PCDHB3	ENST00000231130,p.E320K|NM_018937,p.E320K|uc003lio.3,p.E320K	protein_coding	uc003lio.3	nonsynonymous SNV	exon1	c.G958A	p.E320K	NFEAINSYEVDIEAKDGGGLSGKST	NFEAINSYEVDIKAKDGGGLSGKST	3.0	8.0	-	-	4095_5:140481191-140481191 G>A_NFEAINSYEVDIKAKDGGGLSGKST	0.0
9:119903607-119903607 C>T	0.0	3713	MELANOMA	-	-	-	-	ASTN2	ENST00000373996,p.R389Q|uc022bml.1,p.R38Q|ENST00000373986,p.R116Q|ENST00000313400,p.R389Q|uc022bmm.1,p.R38Q	protein_coding	uc022bmm.1	nonsynonymous SNV	exon2	c.G113A	p.R38Q	TSAGKRKRRSKSRGGISFGRAKGTS	TSAGKRKRRSKSQGGISFGRAKGTS	3.0	8.0	-	-	3713_9:119903607-119903607 C>T_TSAGKRKRRSKSQGGISFGRAKGTS	0.0
1:115828972-115828972 C>T	0.0	4278	COLORECTAL	-	-	ID=COSM1497670;OCCURENCE=1(lung)	-	NGF	ENST00000369512,p.A149T|NM_002506,p.A149T|uc021osd.1,p.A149T|uc001efu.1,p.A149T	protein_coding	uc021osd.1	nonsynonymous SNV	exon1	c.G445A	p.A149T	DSVSVWVGDKTTATDIKGKEVMVLG	DSVSVWVGDKTTTTDIKGKEVMVLG	4.0	9.0	-	-	4278_1:115828972-115828972 C>T_DSVSVWVGDKTTTTDIKGKEVMVLG	0.0
17:27908945-27908945 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GIT1	NM_014030,p.R208K|ENST00000225394,p.R208K|ENST00000579937,p.R208K|uc010wbg.1,p.R208K|ENST00000394869,p.R208K|ENST00000581348,p.R208K|uc002heg.2,p.R208K|uc002hef.2,p.R208K|NM_001085454,p.R208K	retained_intron, protein_coding, nonsense_mediated_decay	uc010wbg.1	nonsynonymous SNV	exon5	c.G623A	p.R208K	PDVNGRTPIDYARQAGHHELAERLV	PDVNGRTPIDYAKQAGHHELAERLV	7.0	3.0	-	-	4258_17:27908945-27908945 C>T_PDVNGRTPIDYAKQAGHHELAERLV	0.0
1:35847180-35847180 C>T	1.0	3716	MELANOMA	-	-	-	-	ZMYM4	NM_005095,p.H464Y|ENST00000373297,p.H464Y|uc009vuv.3,p.H203Y|ENST00000314607,p.H464Y|uc001byu.3,p.H140Y|uc001byt.3,p.H464Y|uc009vuu.3,p.H432Y	protein_coding, processed_transcript	uc009vuv.3	nonsynonymous SNV	exon8	c.C607T	p.H203Y	VIRHEVNYQNVVHKLCSDACFSKFR	VIRHEVNYQNVVYKLCSDACFSKFR	9.0	7.0	CD8	-	3716_1:35847180-35847180 C>T_VIRHEVNYQNVVYKLCSDACFSKFR	1.0
4:120517689-120517689 G>A	1.0	3713	MELANOMA	-	-	-	-	PDE5A	ENST00000264805,p.H232Y|uc003idf.3,p.H232Y|uc003idg.3,p.H222Y|ENST00000354960,p.H274Y|NM_033437,p.H222Y|NM_033430,p.H232Y|uc003idh.3,p.H274Y|ENST00000394439,p.H222Y|NM_001083,p.H274Y	retained_intron, protein_coding, processed_transcript	uc003idh.3	nonsynonymous SNV	exon3	c.C820T	p.H274Y	KTQSILCMPIKNHREEVVGVAQAIN	KTQSILCMPIKNYREEVVGVAQAIN	3.0	10.0	-	-	3713_4:120517689-120517689 G>A_KTQSILCMPIKNYREEVVGVAQAIN	0.0
3:101038613-101038613 G>C	1.0	4196	COLORECTAL	-	-	-	-	IMPG2	NM_016247,p.P50R|uc003duq.2,p.P50R|ENST00000193391,p.P50R	protein_coding	uc003duq.2	nonsynonymous SNV	exon2	c.C149G	p.P50R	IQEPKSAVSFLLPEESTDLSLATKK	IQEPKSAVSFLLREESTDLSLATKK	4.0	10.0	-	-	4196_3:101038613-101038613 G>C_IQEPKSAVSFLLREESTDLSLATKK	0.0
22:42262867-42262867 G>C	0.0	4069	PANCREATIC	-	-	-	-	SREBF2	uc003bbi.3,p.E41Q|NM_004599,p.E41Q|ENST00000361204,p.E41Q|ENST00000424354,p.E41Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003bbi.3	nonsynonymous SNV	exon2	c.G121C	p.E41Q	DEMLQFVSNQVGEFPDLFSEQLCSS	DEMLQFVSNQVGQFPDLFSEQLCSS	10.0	3.0	-	-	4069_22:42262867-42262867 G>C_DEMLQFVSNQVGQFPDLFSEQLCSS	0.0
7:48494709-48494709 G>A	1.0	4284	COLORECTAL	-	-	-	-	ABCA13	ENST00000411975,p.R17Q|uc031sxh.1,p.R1895Q|uc010kys.2,p.R1895Q|uc003toq.2,p.R4214Q|NM_152701,p.R4214Q|ENST00000435803,p.R4214Q|uc031sxg.1,p.R1895Q	retained_intron, protein_coding, nonsense_mediated_decay	uc031sxh.1	nonsynonymous SNV	exon26	c.G5684A	p.R1895Q	QLLRAQVAAILARRLRRTLRAGKST	QLLRAQVAAILAQRLRRTLRAGKST	5.0	9.0	-	-	4284_7:48494709-48494709 G>A_QLLRAQVAAILAQRLRRTLRAGKST	0.0
11:111412293-111412293 A>T	0.0	4335	COLORECTAL	-	-	-	-	LAYN	ENST00000375615,p.D31V|NM_001258390,p.D31V|uc001plr.2,p.D31V|ENST00000525126,p.D31V	protein_coding, processed_transcript, nonsense_mediated_decay	uc001plr.2	nonsynonymous SNV	exon2	c.A92T	p.D31V	LRAATGRLLSASDLDLRGGQPVCRG	LRAATGRLLSASVLDLRGGQPVCRG	6.0	6.0	-	-	4335_11:111412293-111412293 A>T_LRAATGRLLSASVLDLRGGQPVCRG	0.0
16:58030774-58030774 G>A	1.0	4301	MELANOMA	-	-	-	-	ZNF319	uc002emx.1,p.R466C|NM_020807,p.R466C|ENST00000299237,p.R466C|uc021tjd.1,p.R466C	protein_coding	uc021tjd.1	nonsynonymous SNV	exon1	c.C1396T	p.R466C	AEKPLRCTLCERRFFSSSEFVQHRC	AEKPLRCTLCERCFFSSSEFVQHRC	7.0	5.0	-	-	4301_16:58030774-58030774 G>A_AEKPLRCTLCERCFFSSSEFVQHRC	0.0
17:54990779-54990779 G>T	1.0	2359	MELANOMA	-	-	-	-	TRIM25	uc002iut.3,p.L191M|ENST00000537230,p.L191M|NM_005082,p.L191M|ENST00000316881,p.L191M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002iut.3	nonsynonymous SNV	exon1	c.C571A	p.L191M	CLVEHKTCSPASLSQASADLEATLR	CLVEHKTCSPASMSQASADLEATLR	9.0	8.0	-	-	2359_17:54990779-54990779 G>T_CLVEHKTCSPASMSQASADLEATLR	0.0
5:140590706-140590706 G>A	1.0	4240	BREAST	-	-	-	-	PCDHB12	uc003liz.3,p.G743R|ENST00000541609,p.G406R|NM_018932,p.G743R|uc011dak.2,p.G406R|ENST00000239450,p.G743R	protein_coding	uc011dak.2	nonsynonymous SNV	exon2	c.G1216A	p.G406R	PFPGHLVDVSGTGTLSQSYHYEVCV	PFPGHLVDVSGTRTLSQSYHYEVCV	5.0	7.0	-	-	4240_5:140590706-140590706 G>A_PFPGHLVDVSGTRTLSQSYHYEVCV	0.0
14:91739979-91739979 C>T	0.0	4189	MELANOMA	-	-	-	-	CCDC88C	ENST00000331194,p.D217N|uc001xzi.3,p.D143N|uc010aty.3,p.D1693N|NM_001080414,p.D1693N|uc001xzj.3,p.D217N|ENST00000389857,p.D1693N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010aty.3	nonsynonymous SNV	exon30	c.G5077A	p.D1693N	RSSPTHDTPSCRDDLLSDYFRKASD	RSSPTHDTPSCRNDLLSDYFRKASD	6.0	6.0	-	-	4189_14:91739979-91739979 C>T_RSSPTHDTPSCRNDLLSDYFRKASD	0.0
17:57106010-57106010 G>T	1.0	4046	OVARIAN	-	-	-	-	TRIM37	NM_001005207,p.L675I|uc002iwy.4,p.L675I|uc002iwz.4,p.L675I|ENST00000262294,p.L675I|uc002ixa.4,p.L553I|ENST00000376149,p.L553I|uc010woc.2,p.L641I|ENST00000393065,p.L641I|NM_015294,p.L675I|ENST00000393066,p.L675I	retained_intron, protein_coding, nonsense_mediated_decay	uc010woc.2	nonsynonymous SNV	exon18	c.C1921A	p.L641I	QAMWRVPSDLKMLKRLKTQMAEVRC	QAMWRVPSDLKMIKRLKTQMAEVRC	7.0	8.0	-	-	4046_17:57106010-57106010 G>T_QAMWRVPSDLKMIKRLKTQMAEVRC	0.0
4:71115025-71115025 C>T	0.0	3903	MELANOMA	-	-	-	-	CSN3	uc003hfe.4,p.T133I|ENST00000304954,p.T133I|NM_005212,p.T133I	protein_coding	uc003hfe.4	nonsynonymous SNV	exon4	c.C398T	p.T133I	PPKKIQDKIIIPTINTIATVEPTPA	PPKKIQDKIIIPIINTIATVEPTPA	1.0	8.0	-	-	3903_4:71115025-71115025 C>T_PPKKIQDKIIIPIINTIATVEPTPA	0.0
8:95262609-95262609 C>T	1.0	4244	COLORECTAL	-	-	-	-	GEM	ENST00000396194,p.V274M|ENST00000297596,p.V274M|uc003ygi.3,p.V274M|NM_181702,p.V274M|uc003ygj.3,p.V274M|NM_005261,p.V274M	retained_intron, protein_coding	uc003ygj.3	nonsynonymous SNV	exon5	c.G820A	p.V274M	MPRKARRFWGKIVAKNNKNMAFKLK	MPRKARRFWGKIMAKNNKNMAFKLK	8.0	9.0	-	-	4244_8:95262609-95262609 C>T_MPRKARRFWGKIMAKNNKNMAFKLK	0.0
3:44607138-44607138 G>A	0.0	4158	COLORECTAL	-	-	-	-	ZKSCAN7	uc010hin.3,p.G195R|ENST00000273320,p.G195R|uc003cnj.3,p.G195R|uc003cnk.3,p.G195R|NM_001288592,p.G45R|uc010hio.3,p.G45R|uc003cni.3,p.G195R|NM_018651,p.G195R|ENST00000431636,p.G195R|ENST00000426540,p.G195R|ENST00000447279,p.G45R|ENST00000419137,p.G30R|NM_025169,p.G195R|ENST00000341840,p.G195R|NM_001288591,p.G195R|NM_001288590,p.G195R	retained_intron, protein_coding, nonsense_mediated_decay	uc010hio.3	nonsynonymous SNV	exon2	c.G133A	p.G45R	PPYDPGTHHLPSGDFAQCTSPVPTL	PPYDPGTHHLPSRDFAQCTSPVPTL	4.0	5.0	-	-	4158_3:44607138-44607138 G>A_PPYDPGTHHLPSRDFAQCTSPVPTL	0.0
7:92132489-92132489 C>T	1.0	3713	MELANOMA	-	-	-	-	PEX1	ENST00000541751,p.E115K|ENST00000248633,p.E698K|NM_001282678,p.E490K|uc003uly.3,p.E698K|ENST00000438045,p.E376K|uc011khs.2,p.E376K|uc011khr.2,p.E490K|NM_000466,p.E698K	retained_intron, protein_coding, nonsense_mediated_decay	uc011khs.2	nonsynonymous SNV	exon10	c.G1126A	p.E376K	QRLAHALNDMIKEFISMGSLVALIA	QRLAHALNDMIKKFISMGSLVALIA	8.0	8.0	-	-	3713_7:92132489-92132489 C>T_QRLAHALNDMIKKFISMGSLVALIA	0.0
5:81573660-81573660 C>T	1.0	4287	COLORECTAL	-	-	-	-	RPS23	ENST00000510019,p.G6R|ENST00000296674,p.G6R|NM_001025,p.G6R|ENST00000511844,p.G6R|ENST00000510210,p.G6R|ENST00000512493,p.G6R|ENST00000507980,p.G6R|uc003khu.3,p.G6R	retained_intron, protein_coding, processed_transcript	uc003khu.3	nonsynonymous SNV	exon2	c.G16A	p.G6R	MGKCRGLRTARKLRSHRR	MGKCRRLRTARKLRSHRR	10.0	4.0	-	-	4287_5:81573660-81573660 C>T_MGKCRRLRTARKLRSHRR	0.0
3:52406940-52406940 G>A	1.0	4110	BILE DUCT	-	-	-	-	DNAH1	uc011bef.2,p.G2286R|ENST00000420323,p.G2286R|NM_015512,p.G2286R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bef.2	nonsynonymous SNV	exon44	c.G6856A	p.G2286R	DKRRKGVFGPPLGRNFIFFIDDLNM	DKRRKGVFGPPLRRNFIFFIDDLNM	4.0	9.0	-	-	4110_3:52406940-52406940 G>A_DKRRKGVFGPPLRRNFIFFIDDLNM	0.0
8:120886196-120886196 G>A	0.0	4246	COLORECTAL	-	-	-	-	DEPTOR	ENST00000523492,p.G37E|NM_001283012,p.G37E|uc011lid.2,p.G37E	protein_coding, processed_transcript	uc011lid.2	nonsynonymous SNV	exon1	c.G110A	p.G37E	RELERMAEVLVTGEQLRLMSPENTL	RELERMAEVLVTEEQLRLMSPENTL	6.0	10.0	-	-	4246_8:120886196-120886196 G>A_RELERMAEVLVTEEQLRLMSPENTL	0.0
2:72359552-72359552 T>C	0.0	4252	COLORECTAL	-	-	-	-	CYP26B1	ENST00000001146,p.K448R|ENST00000546307,p.K373R|uc010yra.1,p.K431R|NM_001277742,p.K373R|NM_019885,p.K448R|uc002sih.2,p.K448R|ENST00000412253,p.K257R|uc010yrb.2,p.K373R	protein_coding	uc010yrb.2	nonsynonymous SNV	exon5	c.A1118G	p.K373R	GGVRTCLGKHLAKLFLKVLAVELAS	GGVRTCLGKHLARLFLKVLAVELAS	4.0	10.0	-	-	4252_2:72359552-72359552 T>C_GGVRTCLGKHLARLFLKVLAVELAS	0.0
9:93636512-93636512 A>C	0.0	4345	COLORECTAL	-	-	-	1	SYK	NM_001135052,p.Q291H|ENST00000375751,p.Q291H|NM_001174168,p.Q291H|ENST00000375747,p.Q291H|uc004arb.3,p.Q291H|uc004ara.3,p.Q291H	protein_coding, processed_transcript	uc004arb.3	nonsynonymous SNV	exon7	c.A873C	p.Q291H	SHPASSPAQGNRQESTVSFNPYEPE	SHPASSPAQGNRHESTVSFNPYEPE	6.0	6.0	-	-	4345_9:93636512-93636512 A>C_SHPASSPAQGNRHESTVSFNPYEPE	0.0
16:68597118-68597118 C>T	1.0	3713	MELANOMA	-	-	-	-	ZFP90	ENST00000398253,p.S143F|NM_133458,p.S143F|ENST00000570495,p.S143F|uc002ewd.3,p.S143F|uc002ewe.3,p.S143F|uc010cff.3,p.S143F|ENST00000563169,p.S143F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cff.3	nonsynonymous SNV	exon5	c.C428T	p.S143F	QENWKRHLGSEASTQKKIITPQENF	QENWKRHLGSEAFTQKKIITPQENF	3.0	3.0	-	-	3713_16:68597118-68597118 C>T_QENWKRHLGSEAFTQKKIITPQENF	0.0
19:35632105-35632105 T>C	0.0	4186	BREAST	-	-	-	-	FXYD1	NM_001278717,p.V55A|ENST00000588715,p.V55A|ENST00000588081,p.V55A|ENST00000351325,p.V55A|uc002nyd.3,p.V55A|uc002nyc.3,p.V55A|ENST00000589209,p.V55A|NM_001278718,p.V55A|NM_005031,p.V55A|ENST00000588607,p.V55A|NM_021902,p.V55A|ENST00000455515,p.V55A	retained_intron, protein_coding	uc002nyd.3	nonsynonymous SNV	exon4	c.T164C	p.V55A	IAGILFILGILIVLSRRCRCKFNQQ	IAGILFILGILIALSRRCRCKFNQQ	6.0	9.0	-	-	4186_19:35632105-35632105 T>C_IAGILFILGILIALSRRCRCKFNQQ	0.0
22:38121888-38121888 C>T	1.0	3713	MELANOMA	-	-	-	-	TRIOBP	uc003atq.1,p.P1109S|uc003atr.3,p.P1109S|uc003ats.1,p.P937S|ENST00000406386,p.P1109S|NM_001039141,p.P1109S|uc003atu.3,p.P937S	retained_intron, protein_coding, nonsense_mediated_decay	uc003atu.3	nonsynonymous SNV	exon5	c.C2809T	p.P937S	QCQSPQHEPLQLPAPVCIGYRDAPR	QCQSPQHEPLQLSAPVCIGYRDAPR	10.0	5.0	-	-	3713_22:38121888-38121888 C>T_QCQSPQHEPLQLSAPVCIGYRDAPR	0.0
5:102491662-102491662 C>T	1.0	3713	MELANOMA	-	-	-	-	PPIP5K2	NM_015216,p.P485S|NM_001276277,p.P485S|uc010jbo.2,p.P407S|ENST00000414217,p.P485S|ENST00000321521,p.P485S|uc003koe.4,p.P485S|uc003kod.5,p.P485S|ENST00000507921,p.P407S|ENST00000358359,p.P485S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jbo.2	nonsynonymous SNV	exon12	c.C1219T	p.P407S	SGINRKVQLTYLPHGCPKTSSEEED	SGINRKVQLTYLSHGCPKTSSEEED	8.0	5.0	-	-	3713_5:102491662-102491662 C>T_SGINRKVQLTYLSHGCPKTSSEEED	0.0
22:45795077-45795077 C>G	0.0	4238	COLORECTAL	-	-	-	-	SMC1B	NM_148674,p.E337D|NM_001291501,p.E337D|uc003bge.1,p.E120D|uc003bgd.3,p.E337D|uc003bgc.3,p.E337D|ENST00000357450,p.E337D|ENST00000404354,p.E337D	protein_coding	uc003bge.1	nonsynonymous SNV	exon4	c.G360C	p.E120D	QCSKQEDDIKALETELADLDAAWRS	QCSKQEDDIKALDTELADLDAAWRS	1.0	7.0	-	-	4238_22:45795077-45795077 C>G_QCSKQEDDIKALDTELADLDAAWRS	0.0
13:101257339-101257339 G>A	1.0	3713	MELANOMA	-	-	-	-	TMTC4	NM_032813,p.S731F|ENST00000376234,p.S712F|NM_001079669,p.S712F|NM_001286453,p.S601F|ENST00000328767,p.S601F|uc010tja.2,p.S601F|ENST00000342624,p.S731F|uc001vot.3,p.S731F|uc001vou.3,p.S712F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tja.2	nonsynonymous SNV	exon16	c.C1802T	p.S601F	GHLDLAKKHYEISLQLDPTASGTKE	GHLDLAKKHYEIFLQLDPTASGTKE	5.0	8.0	-	-	3713_13:101257339-101257339 G>A_GHLDLAKKHYEIFLQLDPTASGTKE	0.0
4:47853938-47853938 G>T	0.0	4077	BILE DUCT	-	-	-	-	NFXL1	uc003gxp.3,p.R815S|NM_001278624,p.R815S|ENST00000381538,p.R815S|ENST00000507489,p.R815S|uc003gxo.3,p.R140S|uc010igi.3,p.R815S|uc010igh.3,p.R815S|NM_001278623,p.R815S|NM_152995,p.R815S	retained_intron, protein_coding, nonsense_mediated_decay	uc010igi.3	nonsynonymous SNV	exon21	c.C2443A	p.R815S	KRIKKELQCNKVRENQVSIECDTTC	KRIKKELQCNKVSENQVSIECDTTC	6.0	7.0	-	-	4077_4:47853938-47853938 G>T_KRIKKELQCNKVSENQVSIECDTTC	0.0
10:17659217-17659217 G>A	1.0	4252	COLORECTAL	-	-	-	-	PTPLA	uc001iph.1,p.A41V|ENST00000361271,p.A41V|uc001ipi.3,p.A41V|uc001ipg.3,p.A41V|NM_014241,p.A41V|ENST00000326961,p.A41V	retained_intron, protein_coding, nonsense_mediated_decay	uc001ipi.3	nonsynonymous SNV	exon1	c.C122T	p.A41V	LSPTSPRCAATMASSDEDGTNGGAS	LSPTSPRCAATMVSSDEDGTNGGAS	9.0	9.0	-	-	4252_10:17659217-17659217 G>A_LSPTSPRCAATMVSSDEDGTNGGAS	0.0
19:36157731-36157731 C>A	0.0	4287	COLORECTAL	-	-	-	-	UPK1A	uc002oaw.3,p.A6E|NM_001281443,p.A6E|uc010eeh.3,p.A6E|NM_007000,p.A6E|ENST00000222275,p.A6E|ENST00000379013,p.A6E	protein_coding	uc010eeh.3	nonsynonymous SNV	exon1	c.C17A	p.A6E	MASAAAAEAEKGSPVVVG	MASAAEAEAEKGSPVVVG	1.0	8.0	-	-	4287_19:36157731-36157731 C>A_MASAAEAEAEKGSPVVVG	0.0
19:5645402-5645402 A>G	1.0	2369	MELANOMA	0.0	-	-	-	SAFB	ENST00000292123,p.I201V|NM_001201338,p.I201V|uc002mcg.3,p.I201V|ENST00000538656,p.I44V|ENST00000588852,p.I201V|NM_002967,p.I201V|uc010xit.2,p.I44V|uc010xir.2,p.I201V|NM_001201340,p.I132V|ENST00000454510,p.I132V|NM_001201339,p.I201V|ENST00000433404,p.I31V|uc002mcf.3,p.I201V|uc010xis.2,p.I132V|ENST00000592224,p.I201V|uc002mce.4,p.I201V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xit.2	nonsynonymous SNV	exon3	c.A130G	p.I44V	INNLDTSSSDFTILQEIEEPSLEPE	INNLDTSSSDFTVLQEIEEPSLEPE	10.0	4.0	-	-	2369_19:5645402-5645402 A>G_INNLDTSSSDFTVLQEIEEPSLEPE	0.0
7:44286784-44286784 T>C	0.0	4275	COLORECTAL	-	-	-	-	CAMK2B	ENST00000424197,p.I129V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000424197	nonsynonymous SNV	exon6	c.A385G	p.I129V	RTNPPAVCHSHCIQQILEAVLHCHQ	RTNPPAVCHSHCVQQILEAVLHCHQ	4.0	1.0	-	-	4275_7:44286784-44286784 T>C_RTNPPAVCHSHCVQQILEAVLHCHQ	0.0
1:82437593-82437593 C>A	0.0	4259	COLORECTAL	-	-	-	-	LPHN2	ENST00000370721,p.F925L|ENST00000370728,p.F1000L|uc009wcd.3,p.F987L|uc001div.3,p.F987L|ENST00000370715,p.F987L|ENST00000370717,p.F1000L|uc001diw.3,p.F571L|NM_012302,p.F987L|NM_001297705,p.F987L|ENST00000370713,p.F987L|ENST00000271029,p.F1000L|NM_001297706,p.F987L|uc001dit.4,p.F987L|ENST00000394879,p.F987L|uc001diu.3,p.F987L|ENST00000370723,p.F987L|ENST00000319517,p.F987L|uc009wce.1,p.F73L|ENST00000335786,p.F1000L|NM_001297704,p.F987L|ENST00000370730,p.F1000L|ENST00000370725,p.F1000L|ENST00000359929,p.F987L|ENST00000370727,p.F1000L	protein_coding, processed_transcript	uc009wce.1	nonsynonymous SNV	exon2	c.C219A	p.F73L	NYFIWSFIGPVTFIILLNIIFLVIT	NYFIWSFIGPVTLIILLNIIFLVIT	7.0	7.0	-	-	4259_1:82437593-82437593 C>A_NYFIWSFIGPVTLIILLNIIFLVIT	0.0
2:58425718-58425718 G>A	0.0	3713	MELANOMA	-	-	-	-	FANCL	ENST00000402135,p.P184L|NM_001114636,p.P184L|uc002rzx.4,p.P184L|ENST00000417361,p.P67L	retained_intron, protein_coding, processed_transcript	uc002rzx.4	nonsynonymous SNV	exon7	c.C551T	p.P184L	PFCASWTPQVNSPQSSLISIYSQFL	PFCASWTPQVNSLQSSLISIYSQFL	6.0	7.0	-	-	3713_2:58425718-58425718 G>A_PFCASWTPQVNSLQSSLISIYSQFL	0.0
19:55494319-55494319 C>T	0.0	4160	COLORECTAL	-	-	-	-	NLRP2	NM_001174082,p.P396L|ENST00000263437,p.P415L|uc010esp.3,p.P396L|uc002qij.3,p.P418L|uc021vbq.1,p.P418L|uc010yfp.2,p.P395L|uc010esn.3,p.P394L|NM_001174083,p.P395L|ENST00000538819,p.P394L|ENST00000537859,p.P396L|ENST00000543010,p.P418L|ENST00000427260,p.P395L|NM_017852,p.P418L|uc010eso.3,p.P415L|ENST00000391721,p.P394L|NM_001174081,p.P418L|ENST00000448584,p.P418L|ENST00000339757,p.P396L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vbq.1	nonsynonymous SNV	exon6	c.C1253T	p.P418L	TTLKLQMEKGEDPVPTCLTRTGLFL	TTLKLQMEKGEDLVPTCLTRTGLFL	4.0	6.0	-	-	4160_19:55494319-55494319 C>T_TTLKLQMEKGEDLVPTCLTRTGLFL	0.0
3:39184881-39184881 G>A	1.0	3713	MELANOMA	-	-	-	-	CSRNP1	uc003cjh.3,p.P479S|ENST00000273153,p.P479S|NM_033027,p.P479S|uc003cjg.3,p.P479S|ENST00000514182,p.P479S	protein_coding	uc003cjh.3	nonsynonymous SNV	exon5	c.C1435T	p.P479S	NGGLEGSREGSLPGTSVPPSMDAGR	NGGLEGSREGSLSGTSVPPSMDAGR	4.0	4.0	-	-	3713_3:39184881-39184881 G>A_NGGLEGSREGSLSGTSVPPSMDAGR	0.0
17:1800405-1800405 C>T	1.0	2556	MELANOMA	-	-	-	-	RPA1	NM_002945,p.P596L|ENST00000254719,p.P596L|uc002fto.2,p.P596L|ENST00000574049,p.P293L	retained_intron, protein_coding, processed_transcript	uc002fto.2	nonsynonymous SNV	exon17	c.C1787T	p.P596L	ESRIKATVMDVKPVDYREYGRRLVM	ESRIKATVMDVKLVDYREYGRRLVM	9.0	6.0	-	-	2556_17:1800405-1800405 C>T_ESRIKATVMDVKLVDYREYGRRLVM	0.0
11:118355021-118355021 G>A	0.0	4234	NSCLC	-	-	-	1	KMT2A	NM_001197104,p.D1404N|NM_005933,p.D1404N|uc001ptb.3,p.D1404N|ENST00000534358,p.D1404N|ENST00000389506,p.D1404N|uc001pta.3,p.D1404N	retained_intron, protein_coding, processed_transcript	uc001ptb.3	nonsynonymous SNV	exon9	c.G4210A	p.D1404N	KIPADGVHRIRVDFKEDCEAENVWE	KIPADGVHRIRVNFKEDCEAENVWE	8.0	2.0	-	-	4234_11:118355021-118355021 G>A_KIPADGVHRIRVNFKEDCEAENVWE	0.0
6:7585866-7585866 C>T	1.0	2556	MELANOMA	-	-	-	-	DSP	uc003mxq.1,p.R2192C|ENST00000379802,p.R2791C|uc021yle.1,p.R2348C|NM_001008844,p.R2192C|ENST00000418664,p.R2192C|NM_004415,p.R2791C|uc003mxp.1,p.R2791C	retained_intron, protein_coding	uc021yle.1	nonsynonymous SNV	exon24	c.C7042T	p.R2348C	TKLKISYKDAINRSMVEDITGLRLL	TKLKISYKDAINCSMVEDITGLRLL	7.0	4.0	-	-	2556_6:7585866-7585866 C>T_TKLKISYKDAINCSMVEDITGLRLL	0.0
9:125941304-125941304 G>A	1.0	3713	MELANOMA	-	-	-	-	STRBP	ENST00000360998,p.A55V|uc004bns.3,p.A69V|NM_018387,p.A69V|uc004bnu.3,p.A55V|uc004bnv.3,p.A69V|NM_001171137,p.A55V|ENST00000348403,p.A69V|ENST00000447404,p.A69V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004bnv.3	nonsynonymous SNV	exon3	c.C206T	p.A69V	KTEGETEVKKDEAGENYSKDQGGRT	KTEGETEVKKDEVGENYSKDQGGRT	4.0	2.0	-	-	3713_9:125941304-125941304 G>A_KTEGETEVKKDEVGENYSKDQGGRT	0.0
13:25067737-25067737 G>C	1.0	4071	COLORECTAL	-	-	-	-	PARP4	uc001upl.3,p.N292K|ENST00000381989,p.N292K|uc010tdc.2,p.N292K|NM_006437,p.N292K	retained_intron, protein_coding, processed_transcript	uc010tdc.2	nonsynonymous SNV	exon8	c.C876G	p.N292K	HMLLKPVNRISLNDVSKAEGILLLV	HMLLKPVNRISLKDVSKAEGILLLV	10.0	8.0	-	-	4071_13:25067737-25067737 G>C_HMLLKPVNRISLKDVSKAEGILLLV	0.0
1:109486627-109486627 C>T	1.0	2591	MELANOMA	-	-	-	-	CLCC1	NM_001048210,p.R131K|uc001dwf.2,p.R131K|ENST00000356970,p.R131K|ENST00000369971,p.R131K|ENST00000369976,p.R131K|uc001dwh.2,p.R131K|uc021ora.1,p.R131K	protein_coding, processed_transcript	uc021ora.1	nonsynonymous SNV	exon4	c.G392A	p.R131K	GDMHYDAEIILKRETLLEIQKFLNG	GDMHYDAEIILKKETLLEIQKFLNG	8.0	4.0	-	-	2591_1:109486627-109486627 C>T_GDMHYDAEIILKKETLLEIQKFLNG	0.0
11:78381515-78381515 G>A	0.0	2359	MELANOMA	-	-	-	-	TENM4	uc001ozk.4,p.P184S|ENST00000278550,p.P1959S|NM_001098816,p.P1959S|ENST00000530738,p.P423S|uc001ozl.4,p.P1959S	retained_intron, protein_coding, processed_transcript	uc001ozl.4	nonsynonymous SNV	exon32	c.C5875T	p.P1959S	FDKNDRLSSVTMPNVARQTLETIRS	FDKNDRLSSVTMSNVARQTLETIRS	5.0	9.0	-	-	2359_11:78381515-78381515 G>A_FDKNDRLSSVTMSNVARQTLETIRS	0.0
8:27779582-27779582 G>A	0.0	4316	COLORECTAL	-	-	-	-	SCARA5	uc003xgl.3,p.A141V|NM_173833,p.A141V|ENST00000524352,p.A141V|ENST00000301906,p.A98V|ENST00000518030,p.A98V|uc003xgj.3,p.A141V|ENST00000354914,p.A141V|uc003xgk.3,p.A98V	protein_coding	uc003xgl.3	nonsynonymous SNV	exon4	c.C422T	p.A141V	QDALQNQSDSLLALAGAVQRLEGAL	QDALQNQSDSLLVLAGAVQRLEGAL	1.0	10.0	-	-	4316_8:27779582-27779582 G>A_QDALQNQSDSLLVLAGAVQRLEGAL	0.0
18:44738480-44738480 C>T	0.0	4316	COLORECTAL	-	-	-	-	SKOR2	uc031rif.1,p.A1010T|NM_001278063,p.A1010T	protein_coding	uc031rif.1	nonsynonymous SNV	exon7	c.G3028A	p.A1010T	YAASLIRKEKLGAHLSKS	YAASLIRKEKLGTHLSKS	7.0	6.0	-	-	4316_18:44738480-44738480 C>T_YAASLIRKEKLGTHLSKS	0.0
1:152282568-152282568 C>A	1.0	4129	NSCLC	-	-	-	-	FLG	NM_002016,p.R1598S|uc001ezu.1,p.R1598S|ENST00000368799,p.R1598S	protein_coding	uc001ezu.1	nonsynonymous SNV	exon3	c.G4794T	p.R1598S	TSRRQGSSVSQDRDSEGHSEDSERR	TSRRQGSSVSQDSDSEGHSEDSERR	1.0	10.0	-	-	4129_1:152282568-152282568 C>A_TSRRQGSSVSQDSDSEGHSEDSERR	0.0
16:1411953-1411953 T>G	1.0	4345	COLORECTAL	-	-	-	-	GNPTG	NM_032520,p.L105R|ENST00000204679,p.L105R|uc002clm.3,p.L105R	retained_intron, protein_coding, nonsense_mediated_decay	uc002clm.3	nonsynonymous SNV	exon5	c.T314G	p.L105R	EQTFRWNAYSGILGIWHEWEIANNT	EQTFRWNAYSGIRGIWHEWEIANNT	10.0	7.0	CD8	-	4345_16:1411953-1411953 T>G_EQTFRWNAYSGIRGIWHEWEIANNT	1.0
16:65016072-65016072 C>T	0.0	4326	BREAST	-	-	-	1	CDH11	uc002eoj.3,p.D378N|uc010vin.2,p.D252N|ENST00000566827,p.D252N|ENST00000268603,p.D378N|uc002eoi.3,p.D378N|ENST00000394156,p.D378N|NM_001797,p.D378N	retained_intron, protein_coding, processed_transcript	uc010vin.2	nonsynonymous SNV	exon7	c.G754A	p.D252N	DTVTVKISVEDADEPPMFLAPSYIH	DTVTVKISVEDANEPPMFLAPSYIH	9.0	3.0	-	-	4326_16:65016072-65016072 C>T_DTVTVKISVEDANEPPMFLAPSYIH	0.0
1:39877004-39877004 G>T	1.0	4071	COLORECTAL	-	-	-	-	KIAA0754	uc009vvt.1,p.S356I|NM_015038,p.S356I|ENST00000530275,p.S220I	protein_coding	uc009vvt.1	nonsynonymous SNV	exon1	c.G1067T	p.S356I	REKTFLMADEKNSLADIFEEREQAN	REKTFLMADEKNILADIFEEREQAN	6.0	8.0	-	-	4071_1:39877004-39877004 G>T_REKTFLMADEKNILADIFEEREQAN	0.0
9:84606978-84606978 C>A	1.0	4196	COLORECTAL	-	-	-	-	SPATA31D1	ENST00000344803,p.F531L|uc004amn.3,p.F531L|NM_001001670,p.F531L	protein_coding	uc004amn.3	nonsynonymous SNV	exon4	c.C1593A	p.F531L	VLVQRGHSSMFVFFNGITNTSISHE	VLVQRGHSSMFVLFNGITNTSISHE	5.0	6.0	-	-	4196_9:84606978-84606978 C>A_VLVQRGHSSMFVLFNGITNTSISHE	0.0
15:64967089-64967089 C>T	1.0	4258	ENDOMETRIAL	-	-	-	-	ZNF609	uc002ann.3,p.A679V|NM_015042,p.A679V|ENST00000326648,p.A679V	protein_coding, processed_transcript	uc002ann.3	nonsynonymous SNV	exon4	c.C2036T	p.A679V	QIYTFQTATFTAASPGSSSGLTATV	QIYTFQTATFTAVSPGSSSGLTATV	7.0	8.0	-	-	4258_15:64967089-64967089 C>T_QIYTFQTATFTAVSPGSSSGLTATV	0.0
X:144906243-144906243 C>A	0.0	4129	NSCLC	-	-	ID=COSM1682942;OCCURENCE=1(lung)	-	SLITRK2	ENST00000434188,p.P767H|NM_001144008,p.P767H|ENST00000447897,p.P767H|uc011mwr.2,p.P767H|ENST00000413937,p.P767H|uc011mwq.2,p.P767H|NM_001144004,p.P767H|uc022cfn.1,p.P767H|NM_001144006,p.P767H|NM_032539,p.P767H|uc010nso.3,p.P767H|uc011mws.2,p.P767H|NM_001144003,p.P767H|uc011mwt.2,p.P767H|uc004fcd.3,p.P767H|uc010nsp.3,p.P767H|ENST00000370490,p.P767H|uc004fcg.3,p.P767H|NM_001144005,p.P767H|NM_001144010,p.P767H|ENST00000428560,p.P767H|NM_001144009,p.P767H	protein_coding	uc022cfn.1	nonsynonymous SNV	exon1	c.C2300A	p.P767H	LYQNIAERVKELPSAGLVHYNFCTL	LYQNIAERVKELHSAGLVHYNFCTL	1.0	6.0	-	-	4129_X:144906243-144906243 C>A_LYQNIAERVKELHSAGLVHYNFCTL	0.0
19:58145198-58145198 G>C	0.0	4186	BREAST	-	-	-	-	ZNF211	uc010yhc.1,p.L4F|uc002qpt.2,p.L4F|uc002qpr.2,p.L4F|ENST00000544273,p.L4F	retained_intron, protein_coding, nonsense_mediated_decay	uc010yhc.1	nonsynonymous SNV	exon2	c.G12C	p.L4F	MRTLRQREVEYFSKAT	MRTFRQREVEYFSKAT	4.0	3.0	-	-	4186_19:58145198-58145198 G>C_MRTFRQREVEYFSKAT	0.0
20:60963365-60963365 G>A	1.0	3713	MELANOMA	-	-	-	-	RPS21	ENST00000450116,p.G63S|uc002ycs.3,p.G63S|ENST00000343986,p.G63S|uc002ycr.3,p.G63S|NM_001024,p.G63S	protein_coding, processed_transcript	uc002ycs.3	nonsynonymous SNV	exon5	c.G187A	p.G63S	KTYAICGAIRRMGESDDSILRLAKA	KTYAICGAIRRMSESDDSILRLAKA	9.0	7.0	-	-	3713_20:60963365-60963365 G>A_KTYAICGAIRRMSESDDSILRLAKA	0.0
20:61981115-61981115 T>G	0.0	4281	COLORECTAL	-	-	-	-	CHRNA4	uc002yes.3,p.S550R|NM_001256573,p.S374R|uc002yet.2,p.S374R|ENST00000370263,p.S550R|NM_000744,p.S550R|uc010gke.1,p.S479R|uc010gkf.2,p.S374R|uc002yev.2,p.S374R	protein_coding, processed_transcript, nonsense_mediated_decay	uc010gkf.2	nonsynonymous SNV	exon5	c.A1120C	p.S374R	SSVSPSATVKTRSTKAPPPHLPLSP	SSVSPSATVKTRRTKAPPPHLPLSP	4.0	4.0	-	-	4281_20:61981115-61981115 T>G_SSVSPSATVKTRRTKAPPPHLPLSP	0.0
9:119770381-119770381 G>T	0.0	4316	COLORECTAL	-	-	-	-	ASTN2	NM_014010,p.D476E|uc022bml.1,p.D176E|ENST00000373996,p.D527E|ENST00000361209,p.D476E|uc022bmm.1,p.D176E|ENST00000313400,p.D527E|uc004bjt.2,p.D476E|ENST00000373986,p.D254E	protein_coding	uc022bmm.1	nonsynonymous SNV	exon5	c.C528A	p.D176E	GQRTTDACEQLCDPETGECSCHEGY	GQRTTDACEQLCEPETGECSCHEGY	5.0	4.0	-	-	4316_9:119770381-119770381 G>T_GQRTTDACEQLCEPETGECSCHEGY	0.0
7:140453136-140453136 A>T	1.0	3784	MELANOMA	-	-	ID=COSM476;OCCURENCE=3(adrenal_gland),3(urinary_tract),4(genital_tract),7(pancreas),16(liver),68(eye),2(prostate),4161(large_intestine),21(biliary_tract),11(breast),4377(skin),9(small_intestine),1(autonomic_ganglia),20(pituitary),242(ovary),32(soft_tissue),7(testis),459(haematopoietic_and_lymphoid_tissue),9534(thyroid),78(lung),1(meninges),12(upper_aerodigestive_tract),717(NS),15(bone),2(oesophagus),4(stomach),228(central_nervous_system)	1	BRAF	ENST00000479537,p.V28E|uc003vwc.4,p.V600E|NM_004333,p.V600E|ENST00000288602,p.V600E	retained_intron, protein_coding, nonsense_mediated_decay	uc003vwc.4	nonsynonymous SNV	exon15	c.T1799A	p.V600E	LTVKIGDFGLATVKSRWSGSHQFEQ	LTVKIGDFGLATEKSRWSGSHQFEQ	8.0	9.0	-	-	3784_7:140453136-140453136 A>T_LTVKIGDFGLATEKSRWSGSHQFEQ	0.0
11:5798902-5798902 C>A	0.0	4316	COLORECTAL	-	-	-	-	OR52N5	NM_001001922,p.K321N|uc010qzn.2,p.K321N|ENST00000317093,p.K321N	protein_coding	uc010qzn.2	nonsynonymous SNV	exon1	c.G963T	p.K321N	IRKSVIKFFQGDKGAG	IRKSVIKFFQGDNGAG	1.0	9.0	-	-	4316_11:5798902-5798902 C>A_IRKSVIKFFQGDNGAG	0.0
1:222904854-222904854 A>G	0.0	4081	COLORECTAL	-	-	-	-	BROX	uc010put.1,p.D350G|NM_144695,p.D382G|uc001hnq.1,p.D382G|ENST00000340934,p.D382G|NM_001288579,p.D350G|ENST00000539697,p.D350G|NM_001288580,p.D350G|uc010puv.1,p.D350G	protein_coding, processed_transcript	uc010puv.1	nonsynonymous SNV	exon11	c.A1049G	p.D350G	LAAFDLTKRPKDDSTKPKPEEEVKP	LAAFDLTKRPKDGSTKPKPEEEVKP	6.0	3.0	-	-	4081_1:222904854-222904854 A>G_LAAFDLTKRPKDGSTKPKPEEEVKP	0.0
X:125299561-125299561 T>C	0.0	4160	COLORECTAL	-	-	-	2	DCAF12L2	NM_001013628,p.K116R|ENST00000538699,p.K116R|ENST00000360028,p.K116R|uc004euk.2,p.K116R	protein_coding	uc004euk.2	nonsynonymous SNV	exon1	c.A347G	p.K116R	QWLNARQVVCGTKCNTLFVVDVQSG	QWLNARQVVCGTRCNTLFVVDVQSG	1.0	4.0	-	-	4160_X:125299561-125299561 T>C_QWLNARQVVCGTRCNTLFVVDVQSG	0.0
3:43618636-43618636 C>A	1.0	3919	MELANOMA	-	-	-	-	ANO10	ENST00000428472,p.W126L|uc003cmw.3,p.W171L|ENST00000451430,p.W126L|ENST00000414522,p.W237L|NM_001204831,p.W237L|uc011azs.2,p.W237L|uc011azt.2,p.W126L|ENST00000292246,p.W237L|NM_018075,p.W237L|NM_001204832,p.W171L|NM_001204833,p.W126L|ENST00000396091,p.W171L|uc003cmv.3,p.W237L	protein_coding, processed_transcript	uc011azt.2	nonsynonymous SNV	exon4	c.G377T	p.W126L	MAVIGLPYYLFVWEDYDKYVIFASF	MAVIGLPYYLFVLEDYDKYVIFASF	8.0	2.0	-	-	3919_3:43618636-43618636 C>A_MAVIGLPYYLFVLEDYDKYVIFASF	0.0
5:41381956-41381956 T>A	0.0	4278	COLORECTAL	-	-	-	-	PLCXD3	ENST00000328457,p.S262C|NM_001005473,p.S262C|uc003jmm.1,p.S262C|ENST00000377801,p.S262C	protein_coding	uc003jmm.1	nonsynonymous SNV	exon2	c.A784T	p.S262C	TPKASTVVKGVASGLRETITERALP	TPKASTVVKGVACGLRETITERALP	3.0	5.0	-	-	4278_5:41381956-41381956 T>A_TPKASTVVKGVACGLRETITERALP	0.0
2:85866435-85866435 A>G	1.0	4335	COLORECTAL	-	-	-	-	USP39	uc010fgn.2,p.K402R|uc010fgo.4,p.K402R|NM_001256727,p.K324R|ENST00000409470,p.K402R|ENST00000323701,p.K402R|uc002sqb.4,p.K133R|ENST00000409025,p.K402R|NM_006590,p.K402R|ENST00000409766,p.K402R|NM_001256726,p.K402R|NM_001256728,p.K299R|NM_001256725,p.K402R|uc010ysu.3,p.K324R|ENST00000450066,p.K299R|uc010ysv.3,p.K299R|uc002sqe.4,p.K402R|uc002sqg.4,p.K402R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ysv.3	nonsynonymous SNV	exon8	c.A896G	p.K299R	YLTLDLPTAPLYKDEKEQLIIPQVP	YLTLDLPTAPLYRDEKEQLIIPQVP	9.0	6.0	-	-	4335_2:85866435-85866435 A>G_YLTLDLPTAPLYRDEKEQLIIPQVP	0.0
20:30522508-30522508 C>T	0.0	4235	COLORECTAL	-	-	-	-	TTLL9	ENST00000375934,p.R242C	protein_coding	ENST00000375934	nonsynonymous SNV	exon10	c.C724T	p.R242C	LPTTTQRRAASGRCSASGSTWRPNT	LPTTTQRRAASGCCSASGSTWRPNT	3.0	3.0	-	-	4235_20:30522508-30522508 C>T_LPTTTQRRAASGCCSASGSTWRPNT	0.0
15:89399986-89399986 C>G	0.0	4316	COLORECTAL	-	-	-	-	ACAN	NM_013227,p.D1390E|ENST00000561243,p.D1390E|ENST00000352105,p.D1390E|uc010upp.1,p.D1390E|NM_001135,p.D1390E|ENST00000439576,p.D1390E|ENST00000559004,p.D1390E|uc010upo.1,p.D1390E	retained_intron, protein_coding	uc010upp.1	nonsynonymous SNV	exon12	c.C4170G	p.D1390E	GEVLETAAPGVEDISGLPSGEVLET	GEVLETAAPGVEEISGLPSGEVLET	3.0	1.0	-	-	4316_15:89399986-89399986 C>G_GEVLETAAPGVEEISGLPSGEVLET	0.0
7:138872273-138872273 G>A	1.0	4110	BILE DUCT	-	-	-	-	TTC26	ENST00000495038,p.G383E|uc011kqp.1,p.G409E|ENST00000343187,p.G483E|uc011kqo.1,p.G483E|NM_001287512,p.G383E|NM_001144923,p.G483E|uc011kqq.1,p.G383E|ENST00000464848,p.G514E|NM_001287513,p.G409E|NM_024926,p.G514E|ENST00000478836,p.G407E|uc003vut.2,p.G374E|uc003vus.2,p.G514E	protein_coding, processed_transcript, nonsense_mediated_decay	uc011kqq.1	nonsynonymous SNV	exon14	c.G1148A	p.G383E	GACVGIFQMIIAGREPKETLREVLH	GACVGIFQMIIAEREPKETLREVLH	6.0	8.0	-	-	4110_7:138872273-138872273 G>A_GACVGIFQMIIAEREPKETLREVLH	0.0
22:23653975-23653975 ->CCGG	0.0	4266	COLORECTAL	-	-	-	1	BCR	uc011aiy.2,p.S681fs|ENST00000305877,p.S1092fs|NM_004327,p.S1092fs|NM_021574,p.S1048fs|uc002zww.3,p.S1092fs|uc002zwx.3,p.S1048fs|ENST00000359540,p.S1048fs	retained_intron, protein_coding, processed_transcript	uc011aiy.2	frameshift insertion	exon19	c.2041_2042insCCGG	p.S681fs	RRGMEEVGIYRVSGVATDIQALKAA	RRGMEEVGIYRVSGRCGHGHPGTEGSLRRQ	10.0	8.0	-	-	4266_22:23653975-23653975 ->CCGG_RRGMEEVGIYRVSGRCGHGHPGTEGSLRRQ	0.0
4:115544420-115544420 G>T	1.0	4095	COLORECTAL	-	-	-	-	UGT8	NM_001128174,p.K128N|NM_003360,p.K128N|uc003ibt.2,p.K128N|uc003ibs.2,p.K128N|ENST00000507710,p.K128N|ENST00000394511,p.K128N|ENST00000310836,p.K128N	protein_coding	uc003ibt.2	nonsynonymous SNV	exon1	c.G384T	p.K128N	LMVGNHALIQGLKKEKFDLLLVDPN	LMVGNHALIQGLNKEKFDLLLVDPN	8.0	8.0	-	-	4095_4:115544420-115544420 G>T_LMVGNHALIQGLNKEKFDLLLVDPN	0.0
6:149699784-149699784 C>G	1.0	4298	COLORECTAL	-	-	-	-	TAB2	NM_001292034,p.Q245E|uc010kia.1,p.Q245E|uc010kib.2,p.Q245E|ENST00000392282,p.Q245E|ENST00000470466,p.Q245E|uc003qmj.3,p.Q245E|ENST00000538427,p.Q245E|uc011eec.2,p.Q213E|ENST00000367456,p.Q245E|ENST00000536230,p.Q213E|ENST00000286332,p.Q245E|NM_001292035,p.Q213E|NM_015093,p.Q245E	protein_coding, processed_transcript, nonsense_mediated_decay	uc011eec.2	nonsynonymous SNV	exon2	c.C637G	p.Q213E	SGWVSQFNPMNPQQVYQPSQPGPWT	SGWVSQFNPMNPEQVYQPSQPGPWT	10.0	1.0	-	-	4298_6:149699784-149699784 C>G_SGWVSQFNPMNPEQVYQPSQPGPWT	0.0
6:44392244-44392244 C>T	1.0	3713	MELANOMA	-	-	-	-	CDC5L	NM_001253,p.A498V|uc003oxl.3,p.A498V|ENST00000371477,p.A498V	protein_coding	uc003oxl.3	nonsynonymous SNV	exon11	c.C1493T	p.A498V	PKNDFEIVLPENAEKELEEREIDDT	PKNDFEIVLPENVEKELEEREIDDT	6.0	3.0	-	-	3713_6:44392244-44392244 C>T_PKNDFEIVLPENVEKELEEREIDDT	0.0
3:85961679-85961679 T>G	0.0	4160	COLORECTAL	-	-	-	-	CADM2	uc003dql.3,p.V222G|NM_001256503,p.V112G|NM_153184,p.V222G|uc003dqk.3,p.V229G|NM_001167675,p.V229G|NM_001256502,p.V112G|ENST00000405615,p.V222G|NM_001256505,p.V112G|NM_001167674,p.V220G|NM_001256504,p.V112G|uc021xay.1,p.V112G|uc021xba.1,p.V112G|uc003dqm.2,p.V112G|uc003dqj.3,p.V220G|uc021xaz.1,p.V112G|ENST00000407528,p.V220G|ENST00000383699,p.V229G	protein_coding, processed_transcript	uc021xba.1	nonsynonymous SNV	exon5	c.T335G	p.V112G	ESLNATPQVAMQVLEIHYTPSVKII	ESLNATPQVAMQGLEIHYTPSVKII	1.0	6.0	-	-	4160_3:85961679-85961679 T>G_ESLNATPQVAMQGLEIHYTPSVKII	0.0
10:61834218-61834218 G>A	0.0	3903	MELANOMA	-	-	-	-	ANK3	uc001jky.3,p.P2141S|NM_020987,p.P2141S|ENST00000280772,p.P2141S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001jky.3	nonsynonymous SNV	exon37	c.C6421T	p.P2141S	GFETRSEKTPSAPQSAESTGPKPLF	GFETRSEKTPSASQSAESTGPKPLF	4.0	9.0	-	-	3903_10:61834218-61834218 G>A_GFETRSEKTPSASQSAESTGPKPLF	0.0
11:55703216-55703216 A>G	0.0	4278	COLORECTAL	-	-	-	-	OR5I1	uc010ris.2,p.F221L|NM_006637,p.F221L|ENST00000301532,p.F221L	protein_coding	uc010ris.2	nonsynonymous SNV	exon1	c.T661C	p.F221L	EIICFIIIIISYFFILLSVLKIRSF	EIICFIIIIISYLFILLSVLKIRSF	1.0	4.0	-	-	4278_11:55703216-55703216 A>G_EIICFIIIIISYLFILLSVLKIRSF	0.0
4:187003936-187003936 G>A	1.0	2556	MELANOMA	-	-	-	-	TLR3	uc011ckz.2,p.D89N|ENST00000296795,p.D366N|NM_003265,p.D366N|uc003iyq.3,p.D366N|ENST00000504367,p.D89N|ENST00000513189,p.D302N|uc003iyr.3,p.D89N	retained_intron, protein_coding, processed_transcript	uc011ckz.2	nonsynonymous SNV	exon2	c.G265A	p.D89N	LKCLEHLNMEDNDIPGIKSNMFTGL	LKCLEHLNMEDNNIPGIKSNMFTGL	6.0	8.0	-	-	2556_4:187003936-187003936 G>A_LKCLEHLNMEDNNIPGIKSNMFTGL	0.0
19:53668520-53668520 A>C	0.0	4186	BREAST	-	-	-	-	ZNF665	ENST00000396424,p.V408G|ENST00000600412,p.V343G|uc010eqm.1,p.V408G|NM_024733,p.V408G	protein_coding, processed_transcript	uc010eqm.1	nonsynonymous SNV	exon4	c.T1223G	p.V408G	HTGEKPFKCNECVKVFTQYSHLANH	HTGEKPFKCNECGKVFTQYSHLANH	6.0	4.0	-	-	4186_19:53668520-53668520 A>C_HTGEKPFKCNECGKVFTQYSHLANH	0.0
11:133778972-133778972 A>C	0.0	4278	COLORECTAL	-	-	-	-	IGSF9B	ENST00000533871,p.L1436V|uc031qfh.1,p.L1436V|NM_001277285,p.L1436V	protein_coding	uc031qfh.1	nonsynonymous SNV	exon20	c.T4306G	p.L1436V	NSVDHDDPGHATLL	NSVDHDDPGHATVL	4.0	8.0	-	-	4278_11:133778972-133778972 A>C_NSVDHDDPGHATVL	0.0
12:11243903-11243903 G>A	1.0	4252	COLORECTAL	-	-	-	-	TAS2R43	NM_176884,p.P309L|ENST00000531678,p.P309L|uc001qzq.1,p.P309L	protein_coding	uc001qzq.1	nonsynonymous SNV	exon1	c.C926T	p.P309L	MRYWVKGEKTSSP	MRYWVKGEKTSSL	3.0	10.0	-	-	4252_12:11243903-11243903 G>A_MRYWVKGEKTSSL	0.0
19:7509248-7509248 G>C	1.0	4000	MELANOMA	-	-	-	-	ARHGEF18	uc010xjm.1,p.A161P|ENST00000359920,p.A319P|NM_001130955,p.A319P|uc002mgh.3,p.A161P|ENST00000319670,p.A161P|NM_015318,p.A161P|uc002mgi.3,p.A319P	retained_intron, protein_coding	uc010xjm.1	nonsynonymous SNV	exon6	c.G481C	p.A161P	ADDLLETHSHFLARLKERRQESLEE	ADDLLETHSHFLPRLKERRQESLEE	8.0	3.0	-	-	4000_19:7509248-7509248 G>C_ADDLLETHSHFLPRLKERRQESLEE	0.0
4:102776338-102776338 C>T	0.0	3903	MELANOMA	-	-	-	-	BANK1	ENST00000508653,p.P73S|uc010ill.3,p.P73S|NM_017935,p.P206S|NM_001127507,p.P73S|uc003hvy.4,p.P206S|uc003hvz.4,p.P176S|uc003hvx.4,p.P191S|NM_001083907,p.P176S|ENST00000444316,p.P176S|ENST00000504592,p.P191S|ENST00000428908,p.P73S|ENST00000322953,p.P206S	retained_intron, protein_coding, processed_transcript	uc010ill.3	nonsynonymous SNV	exon2	c.C217T	p.P73S	TIPLAVVLPTEIPCENPGEIFIILR	TIPLAVVLPTEISCENPGEIFIILR	3.0	5.0	-	-	3903_4:102776338-102776338 C>T_TIPLAVVLPTEISCENPGEIFIILR	0.0
19:46389013-46389013 G>A	1.0	3784	MELANOMA	-	-	-	-	IRF2BP1	ENST00000302165,p.S7F|NM_015649,p.S7F|uc002pds.1,p.S7F	protein_coding	uc002pds.1	nonsynonymous SNV	exon1	c.C20T	p.S7F	MASVQASRRQWCYLCDLPK	MASVQAFRRQWCYLCDLPK	5.0	5.0	-	-	3784_19:46389013-46389013 G>A_MASVQAFRRQWCYLCDLPK	0.0
2:155099240-155099240 G>T	1.0	4126	NSCLC	-	-	-	-	GALNT13	uc002tyr.4,p.V170L|uc002tyt.4,p.V170L|NM_001301627,p.V170L|ENST00000409237,p.V170L|ENST00000392825,p.V170L|NM_052917,p.V170L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tyt.4	nonsynonymous SNV	exon4	c.G508T	p.V170L	ERDFLKLTLENYVKNLEVPVKIIRM	ERDFLKLTLENYLKNLEVPVKIIRM	4.0	10.0	-	-	4126_2:155099240-155099240 G>T_ERDFLKLTLENYLKNLEVPVKIIRM	0.0
12:25398285-25398285 C>A	1.0	4259	COLORECTAL	-	-	ID=COSM1140136,COSM516;OCCURENCE=15(stomach),1(central_nervous_system),8(upper_aerodigestive_tract),2(oesophagus),3(peritoneum),1776(lung),18(thyroid),17(haematopoietic_and_lymphoid_tissue),2(testis),2(cervix),4(gastrointestinal_tract_(site_indeterminate)),13(soft_tissue),34(ovary),38(endometrium),5(skin),11(breast),8(small_intestine),1(kidney),130(pancreas),4(liver),15(urinary_tract),1(adrenal_gland),1476(large_intestine),51(biliary_tract),10(prostate)	1	KRAS	ENST00000556131,p.G12C|ENST00000557334,p.G12C|ENST00000256078,p.G12C|ENST00000311936,p.G12C|uc001rgp.1,p.G12C|NM_033360,p.G12C|uc001rgq.1,p.G12C|NM_004985,p.G12C	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G34T	p.G12C	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGACGVGKSALTIQLI	8.0	10.0	-	-	4259_12:25398285-25398285 C>A_MTEYKLVVVGACGVGKSALTIQLI	0.0
11:8736180-8736180 C>A	1.0	4160	COLORECTAL	-	-	-	-	ST5	ENST00000526757,p.S220I|NM_139157,p.S220I|NM_005418,p.S640I|ENST00000357665,p.S640I|ENST00000532734,p.S250I|ENST00000313726,p.S640I|uc001mgu.3,p.S220I|ENST00000530991,p.S112I|ENST00000526099,p.S153I|uc001mgt.3,p.S640I|uc009yfr.3,p.S220I|NM_213618,p.S640I|ENST00000534127,p.S640I|ENST00000528527,p.S112I|uc010rbp.2,p.S153I|ENST00000530438,p.S220I|ENST00000533020,p.S112I|uc001mgv.3,p.S640I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rbp.2	nonsynonymous SNV	exon4	c.G458T	p.S153I	RGKKRLKKLSMSSIETASLRDENSE	RGKKRLKKLSMSIIETASLRDENSE	8.0	4.0	-	-	4160_11:8736180-8736180 C>A_RGKKRLKKLSMSIIETASLRDENSE	0.0
6:31322977-31322977 G>A	1.0	4000	MELANOMA	-	-	-	-	HLA-B	uc003nth.2,p.P307S|NM_005514,p.P307S|ENST00000412585,p.P307S|uc003ntg.1,p.P186S	retained_intron, protein_coding, nonsense_mediated_decay	uc003nth.2	nonsynonymous SNV	exon5	c.C919T	p.P307S	TLRWEPSSQSTVPIVGIVAGLAVLA	TLRWEPSSQSTVSIVGIVAGLAVLA	10.0	1.0	-	-	4000_6:31322977-31322977 G>A_TLRWEPSSQSTVSIVGIVAGLAVLA	0.0
17:76510917-76510917 C>T	1.0	4326	BREAST	-	-	-	-	DNAH17	NM_173628,p.S1351N|uc010dhp.2,p.S1351N|ENST00000585328,p.S1348N|ENST00000389840,p.S1347N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010dhp.2	nonsynonymous SNV	exon26	c.G4052A	p.S1351N	TVKNVITSLRAVSELQNPAIRERHW	TVKNVITSLRAVNELQNPAIRERHW	4.0	3.0	-	-	4326_17:76510917-76510917 C>T_TVKNVITSLRAVNELQNPAIRERHW	0.0
16:69711127-69711127 C>A	1.0	3879	MELANOMA	-	-	-	-	NFAT5	ENST00000393742,p.P433T|ENST00000349945,p.P433T|uc002exj.2,p.P433T|uc002exk.2,p.P433T|NM_138714,p.P433T|ENST00000567239,p.P527T|uc002exm.2,p.P509T|ENST00000566899,p.P433T|uc002exn.2,p.P527T|ENST00000354436,p.P509T|NM_173214,p.P433T|ENST00000432919,p.P527T|NM_006599,p.P509T|uc002exh.2,p.P303T|NM_001113178,p.P527T|NM_138713,p.P527T|NM_173215,p.P433T|uc002exi.3,p.P433T|uc002exl.2,p.P527T	retained_intron, protein_coding, nonsense_mediated_decay	uc002exn.2	nonsynonymous SNV	exon10	c.C1579A	p.P527T	ELFHQNHLIVKVPPYHDQHITLPVS	ELFHQNHLIVKVTPYHDQHITLPVS	10.0	2.0	-	-	3879_16:69711127-69711127 C>A_ELFHQNHLIVKVTPYHDQHITLPVS	0.0
17:73999336-73999336 C>T	1.0	4000	MELANOMA	-	-	-	-	CDK3	uc010dgt.3,p.R217C|NM_001258,p.R217C|ENST00000425876,p.R217C|ENST00000586261,p.R177C|ENST00000448471,p.R217C	protein_coding	uc010dgt.3	nonsynonymous SNV	exon7	c.C649T	p.R217C	GDSEIDQLFRIFRMLGTPSEDTWPG	GDSEIDQLFRIFCMLGTPSEDTWPG	4.0	6.0	-	-	4000_17:73999336-73999336 C>T_GDSEIDQLFRIFCMLGTPSEDTWPG	0.0
19:54871655-54871655 G>A	1.0	4244	COLORECTAL	-	-	-	-	LAIR1	ENST00000444687,p.P20L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000444687	nonsynonymous SNV	exon2	c.C59T	p.P20L	LLVKETSGGPDSPDTEPGSSAGTVP	LLVKETSGGPDSLDTEPGSSAGTVP	9.0	7.0	-	-	4244_19:54871655-54871655 G>A_LLVKETSGGPDSLDTEPGSSAGTVP	0.0
15:66727453-66727453 A>G	1.0	4317	COLORECTAL	-	-	-	1	MAP2K1	NM_002755,p.K57E|uc010bhq.3,p.K57E|uc010ujp.2,p.K35E|ENST00000307102,p.K57E	retained_intron, protein_coding	uc010ujp.2	nonsynonymous SNV	exon2	c.A103G	p.K35E	QQRKRLEAFLTQKQKVGELKDDDFE	QQRKRLEAFLTQEQKVGELKDDDFE	8.0	8.0	-	-	4317_15:66727453-66727453 A>G_QQRKRLEAFLTQEQKVGELKDDDFE	0.0
2:109522805-109522805 T>G	1.0	4320	COLORECTAL	-	-	-	-	EDAR	uc010fjn.3,p.K360T|NM_022336,p.K328T|uc010yws.2,p.K360T|ENST00000376651,p.K360T|uc002teq.4,p.K328T|ENST00000258443,p.K328T|ENST00000409271,p.K360T	protein_coding	uc010yws.2	nonsynonymous SNV	exon10	c.A1079C	p.K360T	SNKSAGIQSRRKKILDVYANVCGVV	SNKSAGIQSRRKTILDVYANVCGVV	8.0	2.0	CD8	-	4320_2:109522805-109522805 T>G_SNKSAGIQSRRKTILDVYANVCGVV	2.0
5:142693612-142693612 A>C	0.0	4081	COLORECTAL	-	-	-	-	NR3C1	ENST00000503201,p.L436V|ENST00000343796,p.L436V|ENST00000424646,p.L410V|uc021yfa.1,p.L436V|ENST00000394466,p.L436V|NM_001018076,p.L436V|ENST00000504572,p.L436V|uc011dbk.2,p.L39V|uc003lnb.3,p.L436V|NM_001204261,p.L339V|uc003lmy.3,p.L436V|uc003lna.3,p.L436V|uc003lnd.3,p.L436V|NM_001204260,p.L347V|NM_001204258,p.L410V|NM_001018077,p.L436V|NM_001018074,p.L436V|NM_001024094,p.L436V|NM_001204265,p.L436V|uc021yfb.1,p.L436V|NM_001204264,p.L101V|NM_001204259,p.L351V|NM_001204262,p.L121V|ENST00000415690,p.L436V|NM_000176,p.L436V|uc031slp.1,p.L436V|uc003lmz.3,p.L101V|NM_001018075,p.L436V|ENST00000416954,p.L39V|uc003lne.3,p.L436V|NM_001020825,p.L436V|ENST00000394464,p.L436V|ENST00000231509,p.L436V|uc003lnc.3,p.L436V|uc003lnf.3,p.L436V|NM_001204263,p.L106V	protein_coding, processed_transcript	uc031slp.1	nonsynonymous SNV	exon2	c.T1306G	p.L436V	CSDEASGCHYGVLTCGSCKVFFKRA	CSDEASGCHYGVVTCGSCKVFFKRA	7.0	7.0	-	-	4081_5:142693612-142693612 A>C_CSDEASGCHYGVVTCGSCKVFFKRA	0.0
11:108099960-108099960 A>T	1.0	4345	COLORECTAL	-	-	-	1	ATM	ENST00000527891,p.N81Y|ENST00000452508,p.N81Y|ENST00000527805,p.N81Y|NM_000051,p.N81Y|ENST00000278616,p.N81Y|uc009yxr.1,p.N81Y|ENST00000532931,p.N81Y|ENST00000601453,p.N81Y|uc001pkb.1,p.N81Y|uc001pkc.1,p.N81Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009yxr.1	nonsynonymous SNV	exon5	c.A241T	p.N81Y	QKETECLRIAKPNVSASTQASRQKK	QKETECLRIAKPYVSASTQASRQKK	10.0	6.0	-	-	4345_11:108099960-108099960 A>T_QKETECLRIAKPYVSASTQASRQKK	0.0
4:54325572-54325572 C>A	0.0	4317	COLORECTAL	-	-	-	1	FIP1L1	NM_001134937,p.P575T|NM_030917,p.P581T|ENST00000358575,p.P575T|uc003gzz.3,p.P507T|ENST00000306932,p.P507T|uc003gzy.3,p.P581T|uc003hab.3,p.P546T|ENST00000504094,p.P241T|uc011bzu.2,p.P575T|ENST00000337488,p.P581T|NM_001134938,p.P507T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bzu.2	nonsynonymous SNV	exon18	c.C1723A	p.P575T	KRSKEGKEAGSEPAPEQESTEATPA	KRSKEGKEAGSETAPEQESTEATPA	10.0	2.0	-	-	4317_4:54325572-54325572 C>A_KRSKEGKEAGSETAPEQESTEATPA	0.0
2:216916245-216916245 C>G	1.0	4160	COLORECTAL	-	-	-	-	PECR	ENST00000442122,p.V150L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000442122	nonsynonymous SNV	exon4	c.G448C	p.V150L	MCKAGILELQEQVFTTSPNL	MCKAGILELQEQLFTTSPNL	6.0	8.0	-	-	4160_2:216916245-216916245 C>G_MCKAGILELQEQLFTTSPNL	0.0
X:101971961-101971961 G>T	0.0	4196	COLORECTAL	-	-	-	-	ARMCX5-GPRASP2,GPRASP2	ENST00000332262,p.G722W|uc022cbh.1,p.G722W|NM_138437,p.G722W|ENST00000543253,p.G722W|uc022cbg.1,p.G722W|uc022cay.1,p.G722W|NM_001004051,p.G722W|NM_001199818,p.G722W|NM_001184874,p.G722W|uc004ejm.3,p.G722W|NM_001184875,p.G722W|uc022cbe.1,p.G722W|ENST00000535209,p.G722W|uc022cbf.1,p.G722W|NM_001184876,p.G722W|uc004ejl.3,p.G722W|uc004ejk.3,p.G722W	protein_coding, processed_transcript	uc022cbh.1	nonsynonymous SNV	exon1	c.G2164T	p.G722W	IDYHTLIANYMSGFLSLLTTANART	IDYHTLIANYMSWFLSLLTTANART	6.0	7.0	-	-	4196_X:101971961-101971961 G>T_IDYHTLIANYMSWFLSLLTTANART	0.0
1:92646746-92646746 C>T	1.0	3716	MELANOMA	-	-	-	-	KIAA1107	ENST00000409154,p.P786L|uc001dop.3,p.P656L|uc010otd.2,p.P731L|NM_015237,p.P731L|ENST00000370378,p.P731L	protein_coding	uc010otd.2	nonsynonymous SNV	exon8	c.C2192T	p.P731L	LNSAQEDKKSKVPVEGLTIPSKLSD	LNSAQEDKKSKVLVEGLTIPSKLSD	4.0	9.0	-	-	3716_1:92646746-92646746 C>T_LNSAQEDKKSKVLVEGLTIPSKLSD	0.0
X:68749582-68749582 A>T	0.0	4245	COLORECTAL	-	-	-	-	FAM155B	ENST00000252338,p.Y401F|NM_015686,p.Y401F|uc004dxk.3,p.Y401F	protein_coding	uc004dxk.3	nonsynonymous SNV	exon3	c.A1202T	p.Y401F	SYFHHYHQQYHHYHPHHDPPGRVSN	SYFHHYHQQYHHFHPHHDPPGRVSN	4.0	10.0	-	-	4245_X:68749582-68749582 A>T_SYFHHYHQQYHHFHPHHDPPGRVSN	0.0
X:153608701-153608701 C>A	0.0	4234	NSCLC	-	-	-	-	EMD	ENST00000369842,p.P125T|uc004fkl.3,p.P125T|NM_000117,p.P125T|ENST00000369835,p.P90T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004fkl.3	nonsynonymous SNV	exon4	c.C373A	p.P125T	PSRAVRQSVTSFPDADAFHHQVHDD	PSRAVRQSVTSFTDADAFHHQVHDD	9.0	3.0	-	-	4234_X:153608701-153608701 C>A_PSRAVRQSVTSFTDADAFHHQVHDD	0.0
11:5013194-5013194 G>A	0.0	3795	MELANOMA	-	-	ID=COSM224389;OCCURENCE=1(skin)	-	MMP26	ENST00000380390,p.G199E|ENST00000300762,p.G199E|uc001lzv.3,p.G199E|NM_021801,p.G199E	protein_coding, processed_transcript	uc001lzv.3	nonsynonymous SNV	exon5	c.G596A	p.G199E	FDKNEHWSASDTGYNLFLVATHEIG	FDKNEHWSASDTEYNLFLVATHEIG	1.0	8.0	-	-	3795_11:5013194-5013194 G>A_FDKNEHWSASDTEYNLFLVATHEIG	0.0
6:36104467-36104467 C>T	1.0	3713	MELANOMA	-	-	-	-	MAPK13	ENST00000373759,p.A99V|uc003ols.4,p.A177V|NM_002754,p.A177V|ENST00000373766,p.A177V|ENST00000211287,p.A177V|ENST00000373761,p.A167V	protein_coding, processed_transcript	uc003ols.4	nonsynonymous SNV	exon7	c.C530T	p.A177V	KILDFGLARHADAEMTGYVVTRWYR	KILDFGLARHADVEMTGYVVTRWYR	4.0	8.0	-	-	3713_6:36104467-36104467 C>T_KILDFGLARHADVEMTGYVVTRWYR	0.0
2:25359463-25359463 A>G	1.0	4213	COLORECTAL	-	-	-	-	EFR3B	ENST00000403714,p.K519R|ENST00000264719,p.K398R|uc010eyh.3,p.K519R|NM_014971,p.K519R|ENST00000402191,p.K484R|ENST00000401432,p.K519R|uc002rfw.2,p.K519R|ENST00000405108,p.K371R	protein_coding	uc010eyh.3	nonsynonymous SNV	exon14	c.A1556G	p.K519R	VDKCSRQDTVFMKKHSQQLYRHIYL	VDKCSRQDTVFMRKHSQQLYRHIYL	5.0	10.0	-	-	4213_2:25359463-25359463 A>G_VDKCSRQDTVFMRKHSQQLYRHIYL	0.0
7:119915758-119915758 C>T	0.0	4158	COLORECTAL	-	-	-	-	KCND2	uc003vjj.1,p.P358S|ENST00000331113,p.P358S|NM_012281,p.P358S	retained_intron, protein_coding	uc003vjj.1	nonsynonymous SNV	exon1	c.C1072T	p.P358S	EKGSSASKFTSIPAAFWYTIVTMTT	EKGSSASKFTSISAAFWYTIVTMTT	2.0	9.0	-	-	4158_7:119915758-119915758 C>T_EKGSSASKFTSISAAFWYTIVTMTT	0.0
16:53476615-53476653 AAATCTACCCCCACATTTCAGAGAACGTACTGAGAGATT>-	0.0	4287	COLORECTAL	-	-	-	-	RBL2	NM_005611,p.139_152del|ENST00000544405,p.65_78del|uc002ehi.4,p.139_152del|uc010vgv.1,p.65_78del|ENST00000262133,p.139_152del	retained_intron, protein_coding, processed_transcript	uc010vgv.1	nonframeshift deletion	exon3	c.195_233del	p.65_78del	EFFNKMKKWEDMANLPPHFRERTER	EFFNKMKKWEDMAERNFTVSAVIFK	9.0	6.0	-	-	4287_16:53476615-53476653 AAATCTACCCCCACATTTCAGAGAACGTACTGAGAGATT>-_EFFNKMKKWEDMAERNFTVSAVIFK	0.0
1:31898664-31898664 C>G	1.0	3879	MELANOMA	-	-	-	-	SERINC2	ENST00000536859,p.L176V|NM_018565,p.L176V|NM_001199037,p.L176V|uc021okm.1,p.L181V|uc001bsu.3,p.L117V|NM_178865,p.L172V|NM_001199038,p.L181V|ENST00000536384,p.L176V|ENST00000373710,p.L181V|uc001bst.3,p.L172V|ENST00000373709,p.L172V|uc010ogg.2,p.L176V|NM_001199039,p.L117V|uc010ogh.2,p.L176V	protein_coding, processed_transcript	uc021okm.1	nonsynonymous SNV	exon6	c.C541G	p.L181V	FYFGVVGSFLFILIQLVLLIDFAHS	FYFGVVGSFLFIVIQLVLLIDFAHS	6.0	6.0	-	-	3879_1:31898664-31898664 C>G_FYFGVVGSFLFIVIQLVLLIDFAHS	0.0
5:96118858-96118858 G>A	1.0	4252	COLORECTAL	-	-	-	-	ERAP1	uc003kml.3,p.R728W|uc010jbm.2,p.R540W|NM_001198541,p.R728W|uc003kmm.3,p.R728W|NM_016442,p.R728W|NM_001040458,p.R728W|uc003kmn.3,p.R728W|ENST00000443439,p.R728W|ENST00000296754,p.R728W	retained_intron, protein_coding, processed_transcript	uc010jbm.2	nonsynonymous SNV	exon14	c.C1618T	p.R540W	WTDEGSVSERMLRSQLLLLACVHNY	WTDEGSVSERMLWSQLLLLACVHNY	7.0	6.0	-	-	4252_5:96118858-96118858 G>A_WTDEGSVSERMLWSQLLLLACVHNY	0.0
1:161275686-161275686 A>G	1.0	4284	COLORECTAL	-	-	-	-	MPZ	uc001gaf.4,p.S243P|ENST00000360451,p.S253P|ENST00000463290,p.S243P|ENST00000533357,p.S243P|NM_000530,p.S243P|ENST00000491222,p.S47P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001gaf.4	nonsynonymous SNV	exon6	c.T727C	p.S243P	AVSEKKAKGLGESRKDKK	AVSEKKAKGLGEPRKDKK	4.0	10.0	-	-	4284_1:161275686-161275686 A>G_AVSEKKAKGLGEPRKDKK	0.0
17:42452395-42452395 C>T	0.0	4235	COLORECTAL	-	-	-	-	ITGA2B	NM_000419,p.A938T|uc002igt.1,p.A938T|ENST00000262407,p.A938T	retained_intron, protein_coding	uc002igt.1	nonsynonymous SNV	exon27	c.G2812A	p.A938T	MARGQRAMVTVLAFLWLPSLYQRPL	MARGQRAMVTVLTFLWLPSLYQRPL	3.0	3.0	-	-	4235_17:42452395-42452395 C>T_MARGQRAMVTVLTFLWLPSLYQRPL	0.0
14:36785951-36785951 A>-	1.0	4326	BREAST	-	-	-	-	MBIP	NM_016586,p.F66fs|uc001wtm.2,p.F66fs|uc001wtn.2,p.F66fs|uc001wto.2,p.F66fs|ENST00000416007,p.F66fs|ENST00000318473,p.F66fs|ENST00000359527,p.F66fs|NM_001144891,p.F66fs|ENST00000604160,p.F24fs	protein_coding, processed_transcript	uc001wto.2	frameshift deletion	exon2	c.197delT	p.F66fs	TIDWNKLQSLSAFQPALLFSALEQHI	TIDWNKLQSLSASSLHCSLVHLNNTFYIYSLF	7.0	8.0	-	-	4326_14:36785951-36785951 A>-_TIDWNKLQSLSASSLHCSLVHLNNTFYIYSLF	0.0
1:20964358-20964358 G>T	1.0	4213	COLORECTAL	-	-	ID=COSM3803747;OCCURENCE=1(breast)	-	PINK1	uc001bdm.3,p.K137N|ENST00000321556,p.K137N|NM_032409,p.K137N	protein_coding, processed_transcript	uc001bdm.3	nonsynonymous SNV	exon2	c.G411T	p.K137N	CQEIQAIFTQKSKPGPDPLDTRRLQ	CQEIQAIFTQKSNPGPDPLDTRRLQ	9.0	8.0	-	-	4213_1:20964358-20964358 G>T_CQEIQAIFTQKSNPGPDPLDTRRLQ	0.0
4:169300565-169300565 T>A	1.0	4301	MELANOMA	-	-	-	-	DDX60L	ENST00000511577,p.N1438Y|NM_001012967,p.N1438Y|ENST00000260184,p.N1438Y|uc003irq.4,p.N1438Y|uc021xuh.1,p.N1438Y	retained_intron, protein_coding, processed_transcript	uc021xuh.1	nonsynonymous SNV	exon31	c.A4312T	p.N1438Y	LHGHEPSNLVFVNFLKRGLFHNLCK	LHGHEPSNLVFVYFLKRGLFHNLCK	8.0	4.0	-	-	4301_4:169300565-169300565 T>A_LHGHEPSNLVFVYFLKRGLFHNLCK	0.0
9:4661904-4661904 C>G	0.0	3775	CERVICAL	-	-	-	-	SPATA6L	ENST00000486047,p.E58Q|ENST00000454239,p.E58Q|ENST00000485616,p.E58Q|ENST00000406861,p.E58Q|ENST00000381890,p.E58Q|uc003zim.3,p.E58Q|ENST00000461761,p.E58Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zim.3	nonsynonymous SNV	exon2	c.G172C	p.E58Q	AFPIMIQESMRFEKVFESAVDPGAV	AFPIMIQESMRFQKVFESAVDPGAV	4.0	10.0	-	-	3775_9:4661904-4661904 C>G_AFPIMIQESMRFQKVFESAVDPGAV	0.0
X:10174416-10174416 G>T	0.0	4081	COLORECTAL	-	-	-	-	CLCN4	uc011mid.3,p.G98C|NM_001256944,p.G98C|uc004csy.4,p.G192C|ENST00000380829,p.G192C|ENST00000380833,p.G192C|NM_001830,p.G192C|ENST00000421085,p.G98C	protein_coding	uc011mid.3	nonsynonymous SNV	exon5	c.G292T	p.G98C	GSGIPEIKTILSGFIIRGYLGKWTL	GSGIPEIKTILSCFIIRGYLGKWTL	3.0	6.0	-	-	4081_X:10174416-10174416 G>T_GSGIPEIKTILSCFIIRGYLGKWTL	0.0
13:25276086-25276086 C>T	0.0	4046	OVARIAN	-	-	-	-	ATP12A	NM_001676,p.T632I|NM_001185085,p.T638I|uc001upp.3,p.T632I|ENST00000218548,p.T638I|ENST00000381946,p.T632I|uc010aaa.3,p.T638I	protein_coding	uc010aaa.3	nonsynonymous SNV	exon14	c.C1913T	p.T638I	KCRSAGIKVIMVTGDHPITAKAIAK	KCRSAGIKVIMVIGDHPITAKAIAK	3.0	2.0	-	-	4046_13:25276086-25276086 C>T_KCRSAGIKVIMVIGDHPITAKAIAK	0.0
7:22197478-22197478 T>G	0.0	4317	COLORECTAL	-	-	-	-	RAPGEF5	ENST00000458533,p.K103Q|ENST00000401957,p.K215Q|ENST00000344041,p.K365Q|uc011jyl.1,p.K46Q|NM_012294,p.K365Q|uc003svg.3,p.K365Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jyl.1	nonsynonymous SNV	exon3	c.A136C	p.K46Q	HRRHTVDEYSPQKKNKALFHQFSLK	HRRHTVDEYSPQQKNKALFHQFSLK	9.0	4.0	-	-	4317_7:22197478-22197478 T>G_HRRHTVDEYSPQQKNKALFHQFSLK	0.0
19:19744922-19744922 G>A	1.0	2556	MELANOMA	0.0005	-	-	-	GMIP	uc010xrb.2,p.P695L|NM_016573,p.P721L|NM_001288998,p.P692L|ENST00000445806,p.P692L|NM_001288999,p.P695L|ENST00000587238,p.P695L|ENST00000203556,p.P721L|uc010xrc.2,p.P692L|uc002nnd.3,p.P721L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xrc.2	nonsynonymous SNV	exon18	c.C2075T	p.P692L	NLGIVFGPTLLRPPDGPRAASAIPV	NLGIVFGPTLLRLPDGPRAASAIPV	5.0	9.0	-	-	2556_19:19744922-19744922 G>A_NLGIVFGPTLLRLPDGPRAASAIPV	0.0
2:179431418-179431418 C>G	0.0	3775	CERVICAL	-	-	-	-	TTN	uc021vsy.2,p.A23913P|ENST00000342175,p.A17608P|NM_133437,p.A17608P|ENST00000460472,p.A17416P|uc021vsz.2,p.A17608P|uc021vta.2,p.A17541P|NM_001267550,p.A26481P|ENST00000591111,p.A24840P|uc031rqd.1,p.A24840P|NM_003319,p.A17416P|uc021vtb.2,p.A17416P|uc031rqc.1,p.A26481P|NM_133432,p.A17541P|NM_001256850,p.A24840P|ENST00000589042,p.A26481P|NM_133378,p.A23913P|ENST00000359218,p.A17541P|ENST00000342992,p.A23913P	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon276	c.G74518C	p.A24840P	VGEPSPATVYYKACDPVFKPGPPTN	VGEPSPATVYYKPCDPVFKPGPPTN	2.0	7.0	-	-	3775_2:179431418-179431418 C>G_VGEPSPATVYYKPCDPVFKPGPPTN	0.0
1:247492561-247492561 G>A	1.0	3466	MELANOMA	-	-	-	-	ZNF496	uc001ico.3,p.P107L|ENST00000294753,p.P107L|NM_032752,p.P107L|uc009xgv.3,p.P107L|uc010pyv.1,p.P107L|ENST00000366498,p.P107L	protein_coding, processed_transcript	uc010pyv.1	nonsynonymous SNV	exon1	c.C320T	p.P107L	PREIQSWVRAQEPESGEQAVAAVEA	PREIQSWVRAQELESGEQAVAAVEA	7.0	1.0	-	-	3466_1:247492561-247492561 G>A_PREIQSWVRAQELESGEQAVAAVEA	0.0
5:23522968-23522968 G>A	1.0	4196	COLORECTAL	-	-	-	-	PRDM9	ENST00000296682,p.A286T|NM_020227,p.A286T|uc003jgo.3,p.A286T	protein_coding	uc003jgo.3	nonsynonymous SNV	exon8	c.G856A	p.A286T	GPYEGRITEDEEAANNGYSWLITKG	GPYEGRITEDEETANNGYSWLITKG	5.0	7.0	-	-	4196_5:23522968-23522968 G>A_GPYEGRITEDEETANNGYSWLITKG	0.0
14:24586497-24586497 G>A	1.0	3775	CERVICAL	-	-	-	-	DCAF11	ENST00000560459,p.G84E|ENST00000558914,p.G84E|ENST00000396936,p.G24E|uc001wlz.3,p.G24E|uc001wmc.3,p.G24E|ENST00000560901,p.G84E|ENST00000559288,p.G84E|ENST00000559382,p.G84E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wmc.3	nonsynonymous SNV	exon3	c.G71A	p.G24E	DTTHLWMLPLTPGSWNSMRSRHKWN	DTTHLWMLPLTPESWNSMRSRHKWN	9.0	8.0	-	-	3775_14:24586497-24586497 G>A_DTTHLWMLPLTPESWNSMRSRHKWN	0.0
1:11288763-11288763 G>A	1.0	3713	MELANOMA	-	-	-	1	MTOR	uc001asd.3,p.L998F|NM_004958,p.L998F|ENST00000361445,p.L998F	protein_coding, processed_transcript	uc001asd.3	nonsynonymous SNV	exon19	c.C2992T	p.L998F	CVQFLPQVMPTFLNVIRVCDGAIRE	CVQFLPQVMPTFFNVIRVCDGAIRE	8.0	8.0	-	-	3713_1:11288763-11288763 G>A_CVQFLPQVMPTFFNVIRVCDGAIRE	0.0
1:156779091-156779091 G>T	0.0	4346	COLORECTAL	-	-	-	-	SH2D2A	uc001fqd.2,p.S302R|ENST00000368199,p.S302R|ENST00000392306,p.S312R|uc001fqe.2,p.S284R|uc001fqc.1,p.S274R|ENST00000368198,p.S284R|NM_001161441,p.S312R|NM_001161442,p.S284R|NM_001161443,p.S274R|NM_003975,p.S302R|uc009wsh.2,p.S312R|NM_001161444,p.S302R|uc010phs.1,p.S302R	protein_coding, processed_transcript	uc010phs.1	nonsynonymous SNV	exon7	c.C906A	p.S302R	YAMGRGSPGEAPSNIYVEVEDEGLP	YAMGRGSPGEAPRNIYVEVEDEGLP	3.0	5.0	-	-	4346_1:156779091-156779091 G>T_YAMGRGSPGEAPRNIYVEVEDEGLP	0.0
12:13237915-13237915 G>A	0.0	4275	COLORECTAL	-	-	-	-	GSG1	NM_153823,p.R301W|NM_001206842,p.R314W|ENST00000324458,p.R337W|uc001rbn.3,p.R337W|uc001rbj.3,p.R301W|NM_001206843,p.R273W|ENST00000457134,p.R250W|uc001rbl.3,p.R273W|uc001rbm.3,p.R250W|ENST00000337630,p.R301W|ENST00000537302,p.R273W|ENST00000432710,p.R314W|NM_001080555,p.R337W|uc001rbp.3,p.R314W|ENST00000396310,p.R270W|NM_001206845,p.R250W	protein_coding	uc001rbp.3	nonsynonymous SNV	exon6	c.C940T	p.R314W	SVSEGVDFYSELRNKGFQRGASQEL	SVSEGVDFYSELWNKGFQRGASQEL	1.0	6.0	-	-	4275_12:13237915-13237915 G>A_SVSEGVDFYSELWNKGFQRGASQEL	0.0
22:50727561-50727561 T>A	1.0	4345	COLORECTAL	-	-	-	-	PLXNB2	ENST00000411680,p.K19M|uc003bkv.4,p.K360M|ENST00000432455,p.K360M|ENST00000449103,p.K360M|NM_012401,p.K360M|ENST00000359337,p.K360M	retained_intron, protein_coding, processed_transcript	uc003bkv.4	nonsynonymous SNV	exon4	c.A1079T	p.K360M	DIQCGGHAPGSSKSFPCGSEHLPYP	DIQCGGHAPGSSMSFPCGSEHLPYP	10.0	4.0	-	-	4345_22:50727561-50727561 T>A_DIQCGGHAPGSSMSFPCGSEHLPYP	0.0
11:65061637-65061637 C>T	1.0	2591	MELANOMA	-	-	-	-	POLA2	uc001odj.3,p.L420F|NM_002689,p.L420F|ENST00000265465,p.L420F|uc010rod.1,p.L212F|uc001odk.3,p.L117F|ENST00000541089,p.L212F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010rod.1	nonsynonymous SNV	exon13	c.C634T	p.L212F	TIIEGTRSSGSHLVFVPSLRDVHHE	TIIEGTRSSGSHFVFVPSLRDVHHE	9.0	6.0	CD8	-	2591_11:65061637-65061637 C>T_TIIEGTRSSGSHFVFVPSLRDVHHE	1.0
13:20716385-20716385 G>A	0.0	4316	COLORECTAL	-	-	-	-	GJA3	NM_021954,p.T348M|uc021rgz.1,p.T348M|ENST00000241125,p.T348M|uc001umx.1,p.T348M	protein_coding	uc021rgz.1	nonsynonymous SNV	exon1	c.C1043T	p.T348M	QPPALKAYPAASTPAAPSPVGSSSP	QPPALKAYPAASMPAAPSPVGSSSP	2.0	7.0	-	-	4316_13:20716385-20716385 G>A_QPPALKAYPAASMPAAPSPVGSSSP	0.0
3:141671480-141671480 C>T	1.0	3716	MELANOMA	-	-	-	-	TFDP2	ENST00000397991,p.A378T|ENST00000499676,p.A346T|ENST00000317104,p.A330T|uc003euk.4,p.A378T|uc011bnf.2,p.A309T|ENST00000467072,p.A346T|uc011bng.2,p.A270T|NM_001178141,p.A309T|NM_001178140,p.A378T|ENST00000495310,p.A309T|uc003eun.4,p.A406T|NM_001178139,p.A406T|ENST00000489671,p.A406T|NM_006286,p.A346T|ENST00000477292,p.A270T|ENST00000479040,p.A345T|NM_001178138,p.A346T|uc003eum.4,p.A346T|uc003eul.4,p.A346T|ENST00000310282,p.A346T|NM_001178142,p.A270T|ENST00000486111,p.A346T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bng.2	nonsynonymous SNV	exon8	c.G808A	p.A270T	DAEVALATGQFLAPNSHQSSSAASH	DAEVALATGQFLTPNSHQSSSAASH	6.0	6.0	CD8	-	3716_3:141671480-141671480 C>T_DAEVALATGQFLTPNSHQSSSAASH	1.0
22:42189882-42189882 T>A	0.0	4345	COLORECTAL	-	-	-	-	MEI1	ENST00000400107,p.L465H|NM_152513,p.L1132H|uc010gym.1,p.L465H|uc003bbb.1,p.L518H|ENST00000403492,p.L140H|ENST00000401548,p.L1132H|uc003baz.1,p.L1132H|uc003bbc.1,p.L500H|ENST00000300398,p.L140H|uc003bbd.1,p.L375H|uc003bbg.2,p.L146H	retained_intron, protein_coding, processed_transcript	uc010gym.1	nonsynonymous SNV	exon11	c.T1394A	p.L465H	LSQACVGCLEALLDYLDARSPDIAL	LSQACVGCLEALHDYLDARSPDIAL	4.0	2.0	-	-	4345_22:42189882-42189882 T>A_LSQACVGCLEALHDYLDARSPDIAL	0.0
17:9837503-9837503 G>A	1.0	2098	MELANOMA	-	-	-	1	GAS7	uc002gmh.1,p.H149Y|uc010vvd.1,p.H241Y|NM_201432,p.H229Y|uc002gmj.1,p.H229Y|ENST00000437099,p.H225Y|ENST00000323816,p.H225Y|uc010coh.1,p.H229Y|ENST00000580865,p.H149Y|ENST00000580811,p.H133Y|uc010vvc.1,p.H103Y|ENST00000396115,p.H229Y|ENST00000542249,p.H234Y|NM_003644,p.H149Y|uc002gmg.1,p.H289Y|ENST00000585266,p.H225Y|NM_001130831,p.H225Y|ENST00000432992,p.H289Y|NM_201433,p.H289Y|ENST00000581871,p.H103Y|uc002gmi.2,p.H225Y|ENST00000579158,p.H241Y	retained_intron, protein_coding, processed_transcript	uc010vvd.1	nonsynonymous SNV	exon8	c.C721T	p.H241Y	QVKKSLADEAEVHLKFSAKLHSEVE	QVKKSLADEAEVYLKFSAKLHSEVE	10.0	4.0	CD8	-	2098_17:9837503-9837503 G>A_QVKKSLADEAEVYLKFSAKLHSEVE	1.0
16:31424229-31424229 T>C	0.0	4213	COLORECTAL	-	-	-	-	ITGAD	NM_005353,p.L593P|uc010cap.1,p.L594P|ENST00000389202,p.L593P|uc002ebv.1,p.L593P	retained_intron, protein_coding	uc010cap.1	nonsynonymous SNV	exon15	c.T1781C	p.L594P	QYFGQALSGGQDLTQDGLMDLAVGA	QYFGQALSGGQDPTQDGLMDLAVGA	5.0	5.0	-	-	4213_16:31424229-31424229 T>C_QYFGQALSGGQDPTQDGLMDLAVGA	0.0
19:11917273-11917273 A>C	0.0	4346	COLORECTAL	-	-	-	-	ZNF491	uc021upj.1,p.S169R|ENST00000323169,p.S169R|uc002mso.1,p.S169R|NM_152356,p.S169R	protein_coding, processed_transcript	uc021upj.1	nonsynonymous SNV	exon1	c.A505C	p.S169R	KRYECKQCGKAFSWHSSVRIHERTH	KRYECKQCGKAFRWHSSVRIHERTH	4.0	2.0	-	-	4346_19:11917273-11917273 A>C_KRYECKQCGKAFRWHSSVRIHERTH	0.0
16:30762571-30762571 C>G	1.0	4320	COLORECTAL	-	-	-	-	PHKG2	ENST00000424889,p.I80M|ENST00000565924,p.I80M|ENST00000328273,p.I80M|uc021tgo.1,p.I80M|ENST00000565897,p.I80M|ENST00000563588,p.I80M|NM_000294,p.I80M|uc002dzk.2,p.I80M|NM_001172432,p.I80M	retained_intron, protein_coding, nonsense_mediated_decay	uc021tgo.1	nonsynonymous SNV	exon3	c.C240G	p.I80M	EEVREATRRETHILRQVAGHPHIIT	EEVREATRRETHMLRQVAGHPHIIT	9.0	8.0	-	-	4320_16:30762571-30762571 C>G_EEVREATRRETHMLRQVAGHPHIIT	0.0
1:204945917-204945917 G>A	1.0	4317	COLORECTAL	-	-	-	-	NFASC	ENST00000367170,p.V609M|uc010prb.2,p.V620M|ENST00000430393,p.V596M|ENST00000401399,p.V609M|ENST00000339876,p.V609M|NM_001005388,p.V609M|ENST00000367172,p.V609M|uc001hbj.3,p.V609M|ENST00000338586,p.V609M|NM_001160331,p.V620M|uc010prc.2,p.V176M|ENST00000338515,p.V609M|ENST00000367169,p.V609M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010prc.2	nonsynonymous SNV	exon15	c.G526A	p.V176M	ELDQDLAKAYLTVLADQATPTNRLA	ELDQDLAKAYLTMLADQATPTNRLA	7.0	10.0	-	-	4317_1:204945917-204945917 G>A_ELDQDLAKAYLTMLADQATPTNRLA	0.0
4:2273076-2273076 C>T	1.0	4316	COLORECTAL	-	-	-	-	ZFYVE28	uc003gex.2,p.V832I|uc003gew.2,p.V718I|uc011bvl.2,p.V802I|ENST00000515312,p.V762I|uc011bvk.2,p.V762I|NM_001172659,p.V762I|ENST00000290974,p.V832I|ENST00000508471,p.V137I|NM_001172656,p.V802I|ENST00000511071,p.V802I|NM_020972,p.V832I	retained_intron, protein_coding, processed_transcript	uc011bvl.2	nonsynonymous SNV	exon11	c.G2404A	p.V802I	CGFCTACKAPFTVIRRKHHCRSCGK	CGFCTACKAPFTIIRRKHHCRSCGK	4.0	10.0	-	-	4316_4:2273076-2273076 C>T_CGFCTACKAPFTIIRRKHHCRSCGK	0.0
1:94140392-94140392 G>A	1.0	3903	MELANOMA	-	-	-	-	BCAR3	ENST00000260502,p.S32F|uc001dpz.4,p.S32F|ENST00000370244,p.S32F|NM_003567,p.S32F|NM_001261408,p.S32F|uc001dqa.4,p.S32F|NM_001261409,p.S32F|uc001dqb.4,p.S32F|ENST00000370243,p.S32F	retained_intron, protein_coding, processed_transcript	uc001dqb.4	nonsynonymous SNV	exon4	c.C95T	p.S32F	PLASSMDLLSSRSPLAEHRPDAYQD	PLASSMDLLSSRFPLAEHRPDAYQD	8.0	4.0	-	-	3903_1:94140392-94140392 G>A_PLASSMDLLSSRFPLAEHRPDAYQD	0.0
11:134038064-134038064 G>C	1.0	4266	COLORECTAL	-	-	-	-	NCAPD3	ENST00000527944,p.L39V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000527944	nonsynonymous SNV	exon1	c.C115G	p.L39V	CLSACFADGILPLDLDASELLSDTF	CLSACFADGILPVDLDASELLSDTF	7.0	2.0	-	-	4266_11:134038064-134038064 G>C_CLSACFADGILPVDLDASELLSDTF	0.0
6:10804074-10804074 A>G	1.0	4244	COLORECTAL	-	-	-	-	MAK	ENST00000538030,p.I181T|ENST00000354489,p.I181T|NM_005906,p.I181T|uc021ylk.1,p.I181T|uc021yll.1,p.I181T|ENST00000536370,p.I181T|ENST00000474039,p.I181T|NM_001242385,p.I181T|ENST00000313243,p.I181T|NM_001242957,p.I181T|uc003mzm.3,p.I181T	protein_coding, processed_transcript	uc021yll.1	nonsynonymous SNV	exon7	c.T542C	p.I181T	EVLLRSSVYSSPIDVWAVGSIMAEL	EVLLRSSVYSSPTDVWAVGSIMAEL	4.0	7.0	-	-	4244_6:10804074-10804074 A>G_EVLLRSSVYSSPTDVWAVGSIMAEL	0.0
2:14774561-14774561 T>G	1.0	4252	COLORECTAL	-	-	-	-	FAM84A	uc021ved.1,p.I153S|ENST00000295092,p.I153S|ENST00000331243,p.I153S|NM_145175,p.I153S|uc002rbz.2,p.I153S	protein_coding, processed_transcript	uc021ved.1	nonsynonymous SNV	exon1	c.T458G	p.I153S	APHWAVYVGGGQIIHLHQGEIRQDS	APHWAVYVGGGQSIHLHQGEIRQDS	9.0	2.0	-	-	4252_2:14774561-14774561 T>G_APHWAVYVGGGQSIHLHQGEIRQDS	0.0
3:42251399-42251399 G>C	1.0	4134	NSCLC	-	-	-	-	TRAK1	uc011azj.3,p.E555Q|NM_001265609,p.E555Q|uc003cla.4,p.E571Q|ENST00000396175,p.E571Q|ENST00000341421,p.E571Q|ENST00000327628,p.E629Q|NM_014965,p.E571Q|NM_001042646,p.E629Q|NM_001265608,p.E629Q|uc003cky.4,p.E629Q|uc011azh.3,p.E629Q	protein_coding, processed_transcript, nonsense_mediated_decay	uc011azj.3	nonsynonymous SNV	exon13	c.G1663C	p.E555Q	VDLDEVYCLNDFEEDDTGDHISLPR	VDLDEVYCLNDFQEDDTGDHISLPR	7.0	9.0	-	-	4134_3:42251399-42251399 G>C_VDLDEVYCLNDFQEDDTGDHISLPR	0.0
12:49227104-49227104 T>C	1.0	4037	NSCLC	-	-	-	-	DDX23	NM_004818,p.K587E|uc001rsm.3,p.K587E|ENST00000308025,p.K587E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rsm.3	nonsynonymous SNV	exon13	c.A1759G	p.K587E	QKPDTDEAEDPEKMLANFESGKHKY	QKPDTDEAEDPEEMLANFESGKHKY	9.0	10.0	-	-	4037_12:49227104-49227104 T>C_QKPDTDEAEDPEEMLANFESGKHKY	0.0
14:24886191-24886191 C>G	0.0	4326	BREAST	-	-	-	-	NYNRIN	ENST00000382554,p.L1746V|NM_025081,p.L1746V|uc001wpf.4,p.L1746V	protein_coding, processed_transcript	uc001wpf.4	nonsynonymous SNV	exon9	c.C5236G	p.L1746V	GKKWAASLPLLHLAFRASSTDATPF	GKKWAASLPLLHVAFRASSTDATPF	6.0	5.0	-	-	4326_14:24886191-24886191 C>G_GKKWAASLPLLHVAFRASSTDATPF	0.0
15:82335662-82335662 C>T	0.0	4298	COLORECTAL	-	-	-	-	MEX3B	uc002bgq.2,p.D517N|NM_032246,p.D517N|ENST00000329713,p.D517N	protein_coding	uc002bgq.2	nonsynonymous SNV	exon2	c.G1549A	p.D517N	SSSSGLRRKGSRDCSVCFESEVIAA	SSSSGLRRKGSRNCSVCFESEVIAA	3.0	8.0	-	-	4298_15:82335662-82335662 C>T_SSSSGLRRKGSRNCSVCFESEVIAA	0.0
14:20295870-20295870 C>T	0.0	4275	COLORECTAL	-	-	ID=COSM954072;OCCURENCE=1(large_intestine),1(endometrium)	-	OR4N2	ENST00000568211,p.A88V|ENST00000315947,p.A88V|ENST00000557677,p.A88V|NM_001004723,p.A88V|uc010tkv.2,p.A88V	protein_coding	uc010tkv.2	nonsynonymous SNV	exon1	c.C263T	p.A88V	IVAPRMLVDFLSAKKIISYRGCITQ	IVAPRMLVDFLSVKKIISYRGCITQ	1.0	7.0	-	-	4275_14:20295870-20295870 C>T_IVAPRMLVDFLSVKKIISYRGCITQ	0.0
10:64973823-64973823 G>A	1.0	3919	MELANOMA	-	-	-	-	JMJD1C	uc010qiq.2,p.P520S|ENST00000399262,p.P702S|uc009xpi.3,p.P520S|ENST00000402544,p.P483S|ENST00000542921,p.P520S|uc001jml.3,p.P483S|NM_032776,p.P702S|uc001jmn.3,p.P702S|NM_001282948,p.P520S|ENST00000399251,p.P483S|uc001jmp.1,p.P414S|uc001jmm.3,p.P414S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qiq.2	nonsynonymous SNV	exon7	c.C1558T	p.P520S	PTRSSTLETTKSPLIIDKNEHFTVY	PTRSSTLETTKSSLIIDKNEHFTVY	7.0	10.0	-	-	3919_10:64973823-64973823 G>A_PTRSSTLETTKSSLIIDKNEHFTVY	0.0
2:141250234-141250234 A>C	0.0	4301	MELANOMA	-	-	-	1	LRP1B	uc002tvj.1,p.D3021E|ENST00000389484,p.D3021E|NM_018557,p.D3021E	protein_coding, processed_transcript	uc002tvj.1	nonsynonymous SNV	exon57	c.T9063G	p.D3021E	SLSDEEPFLILADHHEIRKISTDGS	SLSDEEPFLILAEHHEIRKISTDGS	1.0	7.0	-	-	4301_2:141250234-141250234 A>C_SLSDEEPFLILAEHHEIRKISTDGS	0.0
20:36767900-36767900 G>A	1.0	4252	COLORECTAL	-	-	-	-	TGM2	NM_198951,p.S419F|uc002xhs.1,p.S395F|uc002xhr.3,p.S419F|uc002xht.3,p.S419F|ENST00000361475,p.S419F|ENST00000536724,p.S359F|uc010zvy.2,p.S359F|uc010zvx.2,p.S338F|NM_004613,p.S419F|ENST00000536701,p.S338F	retained_intron, protein_coding	uc010zvy.2	nonsynonymous SNV	exon8	c.C1076T	p.S359F	QDDGSVHKSINRSLIVGLKISTKSV	QDDGSVHKSINRFLIVGLKISTKSV	10.0	5.0	-	-	4252_20:36767900-36767900 G>A_QDDGSVHKSINRFLIVGLKISTKSV	0.0
15:50601929-50601929 G>A	0.0	3713	MELANOMA	-	-	-	-	GABPB1	uc001zyf.3,p.R23C|ENST00000359031,p.R23C|ENST00000558335,p.R23C|ENST00000220429,p.R23C|ENST00000560825,p.R23C|NM_181427,p.R23C|uc001zyd.3,p.R23C|uc001zyc.3,p.R23C|NM_005254,p.R23C|ENST00000558970,p.R23C|NM_002041,p.R23C|NM_016655,p.R23C|ENST00000396464,p.R23C|ENST00000380877,p.R23C|uc001zyb.3,p.R23C|uc001zya.3,p.R23C|NM_016654,p.R23C|ENST00000429662,p.R23C|uc001zye.3,p.R23C	retained_intron, protein_coding, TEC	uc001zyf.3	nonsynonymous SNV	exon3	c.C67T	p.R23C	LEAARAGQDDEVRILMANGAPFTTD	LEAARAGQDDEVCILMANGAPFTTD	8.0	2.0	-	-	3713_15:50601929-50601929 G>A_LEAARAGQDDEVCILMANGAPFTTD	0.0
6:138645213-138645214 CC>-	1.0	4326	BREAST	-	-	-	-	KIAA1244	ENST00000251691,p.C1641fs|uc003qhu.3,p.C1641fs|NM_020340,p.C1641fs	protein_coding	uc003qhu.3	frameshift deletion	exon31	c.4923_4924del	p.C1641fs	FHSGTESFSGEGCQVRVAAPSSSPSA	FHSGTESFSGEG	6.0	4.0	-	-	4326_6:138645213-138645214 CC>-_FHSGTESFSGEG	0.0
2:179647145-179647145 C>G	0.0	4298	COLORECTAL	-	-	-	-	TTN	uc021vta.2,p.E1012D|uc021vsy.2,p.E1058D|NM_133379,p.E1058D|uc002unb.3,p.E1058D|uc031rqc.1,p.E1058D|NM_133437,p.E1012D|NM_133432,p.E1012D|NM_003319,p.E1012D|NM_001256850,p.E1058D|uc031rqd.1,p.E1058D|ENST00000591111,p.E1058D|ENST00000342992,p.E1058D|uc021vtb.2,p.E1012D|ENST00000460472,p.E1012D|ENST00000360870,p.E1058D|ENST00000359218,p.E1012D|ENST00000342175,p.E1012D|NM_133378,p.E1058D|ENST00000589042,p.E1058D|uc021vsz.2,p.E1012D|NM_001267550,p.E1058D	retained_intron, protein_coding	uc031rqd.1	nonsynonymous SNV	exon20	c.G3174C	p.E1058D	TEKFTTEEKRFVESRDVVMTDTSLT	TEKFTTEEKRFVDSRDVVMTDTSLT	7.0	8.0	-	-	4298_2:179647145-179647145 C>G_TEKFTTEEKRFVDSRDVVMTDTSLT	0.0
19:36340178-36340178 G>C	0.0	4287	COLORECTAL	-	-	-	-	NPHS1	ENST00000353632,p.A267G|ENST00000378910,p.A267G|uc002oby.3,p.A267G|NM_004646,p.A267G	retained_intron, protein_coding	uc002oby.3	nonsynonymous SNV	exon7	c.C800G	p.A267G	VRAGQSLELPCVARGGNPLATLQWL	VRAGQSLELPCVGRGGNPLATLQWL	3.0	8.0	-	-	4287_19:36340178-36340178 G>C_VRAGQSLELPCVGRGGNPLATLQWL	0.0
6:39835404-39835404 G>C	0.0	4160	COLORECTAL	-	-	-	-	DAAM2	uc003oox.3,p.A183P|uc010jxc.3,p.A183P|NM_001201427,p.A183P|ENST00000398904,p.A183P|ENST00000538976,p.A183P|ENST00000274867,p.A183P|NM_015345,p.A183P|uc003oow.3,p.A183P	retained_intron, protein_coding, processed_transcript	uc010jxc.3	nonsynonymous SNV	exon6	c.G547C	p.A183P	SRIHTSLIGCIKALMNNSQGRAHVL	SRIHTSLIGCIKPLMNNSQGRAHVL	5.0	1.0	-	-	4160_6:39835404-39835404 G>C_SRIHTSLIGCIKPLMNNSQGRAHVL	0.0
19:36051292-36051292 C>T	0.0	4278	COLORECTAL	-	-	-	-	ATP4A	uc002oal.1,p.A254T|NM_000704,p.A254T|ENST00000262623,p.A254T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002oal.1	nonsynonymous SNV	exon6	c.G760A	p.A254T	CTHESPLETRNIAFFSTMCLEGTVQ	CTHESPLETRNITFFSTMCLEGTVQ	4.0	4.0	-	-	4278_19:36051292-36051292 C>T_CTHESPLETRNITFFSTMCLEGTVQ	0.0
2:27598547-27598547 C>T	1.0	4177	PANCREATIC	-	-	-	-	SNX17	uc010ylp.2,p.R292C|NM_001267060,p.R292C|uc010eza.2,p.R103C|NM_014748,p.R317C|NM_001267059,p.R305C|uc010ylo.2,p.R235C|uc010ylk.2,p.R103C|ENST00000543024,p.R103C|uc010yll.2,p.R103C|ENST00000233575,p.R317C|ENST00000542478,p.R103C|NM_001267061,p.R297C|uc010ylq.2,p.R103C|ENST00000537606,p.R292C|uc002rkh.2,p.R103C|uc002rkg.2,p.R317C|uc010ylm.2,p.R103C|uc010ylj.2,p.R297C|uc010yln.2,p.R305C	retained_intron, protein_coding, nonsense_mediated_decay	uc010ylq.2	nonsynonymous SNV	exon10	c.C307T	p.R103C	GQQLREGSFRVTRMRCWRVTSSVPL	GQQLREGSFRVTCMRCWRVTSSVPL	9.0	6.0	-	-	4177_2:27598547-27598547 C>T_GQQLREGSFRVTCMRCWRVTSSVPL	0.0
6:30917807-30917807 C>A	0.0	4326	BREAST	-	-	-	-	DPCR1	ENST00000462446,p.H522Q|NM_080870,p.H522Q|uc003nsg.2,p.H522Q	protein_coding	uc003nsg.2	nonsynonymous SNV	exon2	c.C1566A	p.H522Q	EKTTSSSAEPTEHGERTPLANENTT	EKTTSSSAEPTEQGERTPLANENTT	3.0	1.0	-	-	4326_6:30917807-30917807 C>A_EKTTSSSAEPTEQGERTPLANENTT	0.0
11:62288510-62288510 G>A	1.0	3713	MELANOMA	-	-	-	-	AHNAK	uc001ntl.3,p.S4460F|ENST00000378024,p.S4460F|NM_001620,p.S4460F	protein_coding, processed_transcript	uc001ntl.3	nonsynonymous SNV	exon5	c.C13379T	p.S4460F	KMPEMNIKAPKISMPDFDLHLKGPK	KMPEMNIKAPKIFMPDFDLHLKGPK	10.0	10.0	CD8	-	3713_11:62288510-62288510 G>A_KMPEMNIKAPKIFMPDFDLHLKGPK	1.0
15:23892642-23892642 G>A	0.0	2556	MELANOMA	-	-	-	-	MAGEL2	NM_019066,p.P83L|uc001ywj.4,p.P83L	protein_coding	uc001ywj.4	nonsynonymous SNV	exon1	c.C248T	p.P83L	QLPAPVVPMTQPPALGGPIVPAPPL	QLPAPVVPMTQPLALGGPIVPAPPL	5.0	5.0	-	-	2556_15:23892642-23892642 G>A_QLPAPVVPMTQPLALGGPIVPAPPL	0.0
11:6411896-6411896 G>A	1.0	4317	COLORECTAL	-	-	-	-	SMPD1	NM_000543,p.G23E|NM_001007593,p.G23E|ENST00000533123,p.G23E|ENST00000356761,p.G23E|ENST00000299397,p.G23E|ENST00000531303,p.G23E|ENST00000342245,p.G23E|ENST00000534405,p.G23E|uc001mcw.3,p.G23E|uc021qcz.1,p.G23E|ENST00000527275,p.G23E|uc009yew.3,p.G23E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qcz.1	nonsynonymous SNV	exon1	c.G68A	p.G23E	SCPRSGREQGQDGTAGAPGLLWMGL	SCPRSGREQGQDETAGAPGLLWMGL	7.0	5.0	-	-	4317_11:6411896-6411896 G>A_SCPRSGREQGQDETAGAPGLLWMGL	0.0
5:139941760-139941760 G>A	0.0	4189	MELANOMA	-	-	-	-	APBB3	ENST00000509914,p.P184L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000509914	nonsynonymous SNV	exon6	c.C551T	p.P184L	MILKKDAMSLVNPLDHSLIHCQPLA	MILKKDAMSLVNLLDHSLIHCQPLA	6.0	10.0	-	-	4189_5:139941760-139941760 G>A_MILKKDAMSLVNLLDHSLIHCQPLA	0.0
9:27562392-27562392 G>A	1.0	2359	MELANOMA	-	-	-	-	C9orf72	NM_001256054,p.P196L|ENST00000379997,p.P196L|uc003zqq.3,p.P196L|uc022bfa.2,p.P196L|ENST00000380003,p.P196L|NM_018325,p.P196L|ENST00000379995,p.P196L|NM_145005,p.P196L|uc003zqr.2,p.P196L	protein_coding, processed_transcript	uc022bfa.2	nonsynonymous SNV	exon4	c.C587T	p.P196L	MELLSSMKSHSVPEEIDIADTVLND	MELLSSMKSHSVLEEIDIADTVLND	7.0	9.0	-	-	2359_9:27562392-27562392 G>A_MELLSSMKSHSVLEEIDIADTVLND	0.0
12:112182555-112182555 T>A	1.0	3466	MELANOMA	-	-	-	-	ACAD10	ENST00000392636,p.M210K|uc001tsp.3,p.M608K|ENST00000313698,p.M608K|NM_025247,p.M608K|uc009zvx.3,p.M639K|ENST00000455480,p.M639K|NM_001136538,p.M639K|ENST00000549590,p.M608K|uc001tsq.3,p.M608K	retained_intron, protein_coding, processed_transcript	uc009zvx.3	nonsynonymous SNV	exon14	c.T1916A	p.M639K	FAVKEGFRVFKEMPFTNPLTRSYHT	FAVKEGFRVFKEKPFTNPLTRSYHT	7.0	4.0	-	-	3466_12:112182555-112182555 T>A_FAVKEGFRVFKEKPFTNPLTRSYHT	0.0
10:83635617-83635617 C>T	0.0	4346	COLORECTAL	-	-	-	-	NRG3	uc021pvc.1,p.P174L|ENST00000372141,p.P174L|NM_001165972,p.P174L|NM_001010848,p.P174L|uc001kco.2,p.P174L|ENST00000404547,p.P174L|uc010qlz.1,p.P174L	protein_coding, nonsense_mediated_decay	uc021pvc.1	nonsynonymous SNV	exon1	c.C521T	p.P174L	TRAPTRFPGHRVPIRASPRSTTARN	TRAPTRFPGHRVLIRASPRSTTARN	2.0	5.0	-	-	4346_10:83635617-83635617 C>T_TRAPTRFPGHRVLIRASPRSTTARN	0.0
12:27842047-27842047 C>T	1.0	3466	MELANOMA	-	-	-	1	PPFIBP1	ENST00000318304,p.L872F|ENST00000542629,p.L841F|uc010sjr.1,p.L703F|ENST00000228425,p.L866F|NM_003622,p.L866F|ENST00000537927,p.L719F|NM_001198916,p.L841F|uc001ric.2,p.L872F|uc001rib.2,p.L866F|uc001ria.3,p.L841F|uc001rif.2,p.L379F|uc001rid.2,p.L719F|NM_177444,p.L872F|NM_001198915,p.L719F|ENST00000540114,p.L703F	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc010sjr.1	nonsynonymous SNV	exon23	c.C2107T	p.L703F	TLLRRHLATHFNLLIGAEAQHQKRD	TLLRRHLATHFNFLIGAEAQHQKRD	10.0	4.0	-	-	3466_12:27842047-27842047 C>T_TLLRRHLATHFNFLIGAEAQHQKRD	0.0
19:11121065-11121065 A>G	1.0	4252	COLORECTAL	-	-	-	1	SMARCA4	NM_001128848,p.K711R|NM_001128844,p.K711R|NM_001128846,p.K711R|NM_003072,p.K711R|uc010dxs.3,p.K711R|uc002mqj.4,p.K711R|uc002mqf.4,p.K711R|ENST00000590574,p.K711R|ENST00000450717,p.K711R|ENST00000344626,p.K711R|ENST00000413806,p.K711R|uc010dxr.3,p.K711R|ENST00000444061,p.K711R|uc010dxq.3,p.K711R|ENST00000541122,p.K711R|ENST00000589677,p.K711R|uc010dxo.3,p.K711R|ENST00000429416,p.K711R|NM_001128845,p.K711R|uc002mqg.1,p.K711R|uc010dxp.3,p.K711R|NM_001128849,p.K711R|ENST00000358026,p.K711R|NM_001128847,p.K711R	retained_intron, protein_coding, processed_transcript	uc010dxs.3	nonsynonymous SNV	exon14	c.A2132G	p.K711R	SEVDARHIIENAKQDVDDEYGVSQA	SEVDARHIIENARQDVDDEYGVSQA	10.0	3.0	-	-	4252_19:11121065-11121065 A>G_SEVDARHIIENARQDVDDEYGVSQA	0.0
20:47736572-47736572 A>G	1.0	3716	MELANOMA	-	-	-	-	STAU1	NM_001037328,p.F279L|ENST00000371792,p.F271L|uc002xuf.3,p.F279L|NM_004602,p.F273L|ENST00000360426,p.F273L|uc002xub.3,p.F279L|NM_017452,p.F273L|ENST00000371828,p.F279L|ENST00000347458,p.F273L|uc002xuc.3,p.F273L|NM_017453,p.F354L|ENST00000340954,p.F273L|uc002xua.3,p.F273L|uc002xug.3,p.F354L|NM_017454,p.F273L|ENST00000371802,p.F279L|uc002xud.3,p.F354L|ENST00000371856,p.F354L|uc002xue.3,p.F273L	protein_coding	uc002xug.3	nonsynonymous SNV	exon9	c.T1060C	p.F354L	RNAAENMLEILGFKVPQAQPTKPAL	RNAAENMLEILGLKVPQAQPTKPAL	10.0	1.0	-	-	3716_20:47736572-47736572 A>G_RNAAENMLEILGLKVPQAQPTKPAL	0.0
7:73097318-73097318 G>C	1.0	4134	NSCLC	-	-	-	-	DNAJC30	uc003tys.1,p.R146G|ENST00000395176,p.R146G|NM_032317,p.R146G	protein_coding	uc003tys.1	nonsynonymous SNV	exon1	c.C436G	p.R146G	DPGSPRTPPPTSRTHDGSRASPGAN	DPGSPRTPPPTSGTHDGSRASPGAN	7.0	3.0	-	-	4134_7:73097318-73097318 G>C_DPGSPRTPPPTSGTHDGSRASPGAN	0.0
20:2312918-2312918 G>C	0.0	3775	CERVICAL	-	-	-	-	TGM3	NM_003245,p.W535S|ENST00000381458,p.W535S|uc002wfx.4,p.W535S	protein_coding, processed_transcript	uc002wfx.4	nonsynonymous SNV	exon10	c.G1604C	p.W535S	TIIYNGTLVHEVWKDSATMSLDPEE	TIIYNGTLVHEVSKDSATMSLDPEE	1.0	5.0	-	-	3775_20:2312918-2312918 G>C_TIIYNGTLVHEVSKDSATMSLDPEE	0.0
6:152265335-152265335 G>C	0.0	4186	BREAST	-	-	-	1	ESR1	NM_001291241,p.R262T|uc010kip.3,p.R262T	protein_coding, processed_transcript	uc010kip.3	nonsynonymous SNV	exon5	c.G785C	p.R262T	MMKGIRKDRRGGRMLKHKRQRDDGE	MMKGIRKDRRGGTMLKHKRQRDDGE	3.0	9.0	-	-	4186_6:152265335-152265335 G>C_MMKGIRKDRRGGTMLKHKRQRDDGE	0.0
1:144220887-144220887 T>G	1.0	4284	COLORECTAL	-	-	-	-	NBPF20	uc010oxn.2,p.L625V|uc021otp.1,p.L542V|uc021oto.2,p.L542V|uc010oyd.2,p.L54V|uc001ekk.2,p.L298V|ENST00000369373,p.L52V|uc021otv.1,p.L298V|NM_001278267,p.L1576V|uc021otu.1,p.L298V	protein_coding	uc021otv.1	nonsynonymous SNV	exon13	c.T892G	p.L298V	YSTPSGYLELPDLGQPYSSAVYSLE	YSTPSGYLELPDVGQPYSSAVYSLE	10.0	7.0	-	-	4284_1:144220887-144220887 T>G_YSTPSGYLELPDVGQPYSSAVYSLE	0.0
11:49207269-49207269 T>G	0.0	4278	COLORECTAL	-	-	-	-	FOLH1	NM_001193471,p.N245H|uc001ngz.3,p.N260H|ENST00000533034,p.N245H|ENST00000356696,p.N260H|uc001ngy.3,p.N260H|NM_004476,p.N260H|NM_001014986,p.N260H|ENST00000256999,p.N260H|uc009yly.3,p.N245H|uc009ylz.3,p.N245H|ENST00000340334,p.N245H|NM_001193472,p.N245H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009ylz.3	nonsynonymous SNV	exon7	c.A733C	p.N245H	LPGGGVQRGNILNLNGAGDPLTPGY	LPGGGVQRGNILHLNGAGDPLTPGY	6.0	4.0	-	-	4278_11:49207269-49207269 T>G_LPGGGVQRGNILHLNGAGDPLTPGY	0.0
11:64428413-64428413 C>T	0.0	4275	COLORECTAL	0.0005	-	-	-	NRXN2	uc021qkw.1,p.R666H|NM_015080,p.R666H|ENST00000377551,p.R666H|ENST00000265459,p.R666H|uc021qkx.1,p.R635H|ENST00000409571,p.R659H|uc001oas.3,p.R635H|ENST00000377559,p.R635H|uc001oaq.3,p.R333H|NM_138732,p.R635H	retained_intron, protein_coding, processed_transcript	uc021qkx.1	nonsynonymous SNV	exon9	c.G1904A	p.R635H	YVGCVRDLFIDGRSRDLRGLAEAQG	YVGCVRDLFIDGHSRDLRGLAEAQG	7.0	8.0	-	-	4275_11:64428413-64428413 C>T_YVGCVRDLFIDGHSRDLRGLAEAQG	0.0
1:34052209-34052209 C>T	0.0	4246	COLORECTAL	-	-	ID=COSM4165160,COSM4165159;OCCURENCE=1(kidney)	-	CSMD2	uc001bxm.1,p.V2316I|ENST00000241312,p.V2318I|NM_001281956,p.V2316I|uc001bxn.1,p.V2318I|ENST00000373381,p.V2316I|NM_052896,p.V2318I	protein_coding, processed_transcript, nonsense_mediated_decay	uc001bxn.1	nonsynonymous SNV	exon47	c.G6952A	p.V2318I	VTENEEFNIGDIVRYRCLPGFTLVG	VTENEEFNIGDIIRYRCLPGFTLVG	3.0	6.0	-	-	4246_1:34052209-34052209 C>T_VTENEEFNIGDIIRYRCLPGFTLVG	0.0
6:107069350-107069350 G>A	1.0	2591	MELANOMA	-	-	-	-	RTN4IP1	ENST00000539449,p.P149S|ENST00000369063,p.P149S|NM_032730,p.P149S|uc003prk.3,p.P49S|uc003prj.3,p.P149S|uc010kdd.3,p.P149S	protein_coding, processed_transcript	uc010kdd.3	nonsynonymous SNV	exon3	c.C445T	p.P149S	FKPGDEVWAAVPPWKQGTLSEFVVV	FKPGDEVWAAVPSWKQGTLSEFVVV	6.0	4.0	-	-	2591_6:107069350-107069350 G>A_FKPGDEVWAAVPSWKQGTLSEFVVV	0.0
5:178310049-178310049 C>T	1.0	3775	CERVICAL	-	-	-	-	ZNF354B	uc003mjl.3,p.S199L|ENST00000322434,p.S199L|uc003mjm.3,p.S199L|NM_058230,p.S199L	protein_coding, processed_transcript	uc003mjm.3	nonsynonymous SNV	exon4	c.C596T	p.S199L	KCEIQRNSFKQNSNLLNQSKIKTAE	KCEIQRNSFKQNLNLLNQSKIKTAE	7.0	10.0	-	-	3775_5:178310049-178310049 C>T_KCEIQRNSFKQNLNLLNQSKIKTAE	0.0
1:161173318-161173318 C>T	1.0	3775	CERVICAL	-	-	-	-	NDUFS2	ENST00000392179,p.P63S|uc001fyv.3,p.P63S|ENST00000367993,p.P63S|NM_001166159,p.P63S|uc001fyw.3,p.P63S|NM_004550,p.P63S	protein_coding, processed_transcript	uc001fyw.3	nonsynonymous SNV	exon2	c.C187T	p.P63S	VMYPSKETAHWKPPPWNDVDPPKDT	VMYPSKETAHWKSPPWNDVDPPKDT	10.0	10.0	-	-	3775_1:161173318-161173318 C>T_VMYPSKETAHWKSPPWNDVDPPKDT	0.0
5:13841871-13841871 C>T	0.0	4246	COLORECTAL	-	-	-	-	DNAH5	uc003jfd.2,p.R1805H|NM_001369,p.R1805H|ENST00000265104,p.R1805H	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon33	c.G5414A	p.R1805H	LEESQSSLHLVIRQAAANIQETGFQ	LEESQSSLHLVIHQAAANIQETGFQ	4.0	3.0	-	-	4246_5:13841871-13841871 C>T_LEESQSSLHLVIHQAAANIQETGFQ	0.0
8:27097502-27097502 G>A	0.0	4298	COLORECTAL	-	-	-	-	STMN4	uc011lai.2,p.R193W|uc011laj.2,p.R157W|ENST00000519997,p.R157W|ENST00000523048,p.R193W|NM_001283055,p.R157W|NM_001283053,p.R193W	retained_intron, protein_coding	uc011laj.2	nonsynonymous SNV	exon4	c.C469T	p.R157W	ENREAHLAAMLERLQEKEPPAAR	ENREAHLAAMLEWLQEKEPPAAR	2.0	7.0	-	-	4298_8:27097502-27097502 G>A_ENREAHLAAMLEWLQEKEPPAAR	0.0
3:97851948-97851948 T>C	0.0	4158	COLORECTAL	-	-	-	-	OR5H1	uc011bgt.2,p.M136T|NM_001005338,p.M136T|ENST00000354565,p.M136T	protein_coding	uc011bgt.2	nonsynonymous SNV	exon1	c.T407C	p.M136T	VAICKPLLYPAIMTNGLCIRLLILS	VAICKPLLYPAITTNGLCIRLLILS	1.0	9.0	-	-	4158_3:97851948-97851948 T>C_VAICKPLLYPAITTNGLCIRLLILS	0.0
20:376999-376999 G>T	1.0	4234	NSCLC	-	-	-	-	TRIB3	ENST00000422053,p.G275C|uc002wdm.3,p.G248C|uc002wdn.3,p.G275C|NM_001301196,p.G248C|ENST00000449710,p.G248C|ENST00000217233,p.G248C|NM_001301190,p.G248C|NM_001301201,p.G275C|NM_001301188,p.G248C|NM_001301193,p.G248C|NM_021158,p.G248C	protein_coding, processed_transcript	uc002wdn.3	nonsynonymous SNV	exon5	c.G823T	p.G275C	SYSGKAADVWSLGVALFTMLAGHYP	SYSGKAADVWSLCVALFTMLAGHYP	8.0	6.0	-	-	4234_20:376999-376999 G>T_SYSGKAADVWSLCVALFTMLAGHYP	0.0
5:21752012-21752012 G>A	0.0	3903	MELANOMA	-	-	-	-	CDH12	ENST00000522262,p.A700V|uc010iuc.2,p.A740V|uc003jgk.2,p.A740V|ENST00000382254,p.A740V|uc011cno.1,p.A700V|NM_004061,p.A740V|ENST00000504376,p.A740V	retained_intron, protein_coding, processed_transcript	uc011cno.1	nonsynonymous SNV	exon12	c.C2099T	p.A700V	PTAPPYDSLATYAYEGSGSVAESLS	PTAPPYDSLATYVYEGSGSVAESLS	1.0	9.0	-	-	3903_5:21752012-21752012 G>A_PTAPPYDSLATYVYEGSGSVAESLS	0.0
14:93673673-93673673 G>C	1.0	4240	BREAST	-	-	-	-	UBR7	ENST00000013070,p.E13Q|ENST00000556871,p.E13Q|uc001ybm.4,p.E13Q|NM_175748,p.E13Q|ENST00000553674,p.E13Q|ENST00000554232,p.E13Q	protein_coding, nonsense_mediated_decay	uc001ybm.4	nonsynonymous SNV	exon1	c.G37C	p.E13Q	MAGAEGAAGRQSELEPVVSLVDVLE	MAGAEGAAGRQSQLEPVVSLVDVLE	9.0	8.0	-	-	4240_14:93673673-93673673 G>C_MAGAEGAAGRQSQLEPVVSLVDVLE	0.0
20:51872368-51872368 G>T	0.0	4126	NSCLC	-	-	-	-	TSHZ2	uc002xwo.3,p.A791S|NM_173485,p.A791S|uc021wex.1,p.A788S|NM_001193421,p.A788S|ENST00000329613,p.A788S|ENST00000371497,p.A791S|ENST00000603338,p.A788S	protein_coding, processed_transcript	uc021wex.1	nonsynonymous SNV	exon2	c.G2362T	p.A788S	QAQSCMSPPQKHALSDIADMVKVLP	QAQSCMSPPQKHSLSDIADMVKVLP	5.0	4.0	-	-	4126_20:51872368-51872368 G>T_QAQSCMSPPQKHSLSDIADMVKVLP	0.0
13:101844357-101844357 C>T	0.0	4316	COLORECTAL	-	-	-	-	NALCN	ENST00000376196,p.V559I|uc001vox.1,p.V559I|uc001voy.3,p.V274I|uc001voz.2,p.V559I|ENST00000251127,p.V559I|uc001vpa.2,p.V559I|NM_052867,p.V559I	retained_intron, protein_coding, processed_transcript	uc001vpa.2	nonsynonymous SNV	exon14	c.G1675A	p.V559I	MFQILTQEGWVDVMDQTLNAVGHMW	MFQILTQEGWVDIMDQTLNAVGHMW	2.0	8.0	-	-	4316_13:101844357-101844357 C>T_MFQILTQEGWVDIMDQTLNAVGHMW	0.0
6:34214319-34214319 G>T	1.0	4134	NSCLC	-	-	-	-	C6orf1	uc003oji.4,p.A131E|ENST00000481533,p.A151E|uc003ojg.3,p.A151E|ENST00000468145,p.A151E|uc003ojh.3,p.A151E|NM_001287398,p.A131E|NM_178508,p.A151E|ENST00000413013,p.A131E|ENST00000394990,p.A151E|NM_001287397,p.A131E|ENST00000476320,p.A151E|NM_001287396,p.A151E|ENST00000335352,p.A131E|uc003ojf.3,p.A151E|NM_001008704,p.A151E|NM_001008703,p.A151E	retained_intron, protein_coding	uc003oji.4	nonsynonymous SNV	exon4	c.C392A	p.A131E	ALMGRGFPSGMGAAGRHLCFL	ALMGRGFPSGMGEAGRHLCFL	10.0	3.0	-	-	4134_6:34214319-34214319 G>T_ALMGRGFPSGMGEAGRHLCFL	0.0
17:14205096-14205096 G>C	0.0	4110	BILE DUCT	-	-	-	-	HS3ST3B1	ENST00000466596,p.R87S|NM_006041,p.R87S|uc002goh.1,p.R87S|ENST00000360954,p.R87S	protein_coding, nonsense_mediated_decay	uc002goh.1	nonsynonymous SNV	exon1	c.G261C	p.R87S	PALATAPDGTPPRLPFRAPPATPLA	PALATAPDGTPPSLPFRAPPATPLA	4.0	5.0	-	-	4110_17:14205096-14205096 G>C_PALATAPDGTPPSLPFRAPPATPLA	0.0
7:139092010-139092010 G>T	1.0	3879	MELANOMA	-	-	-	-	C7orf55-LUC7L2,LUC7L2	uc011kqs.2,p.D198Y|uc003vuz.1,p.D148Y|uc003vux.4,p.D201Y|NM_001270643,p.D200Y|ENST00000354926,p.D201Y|uc003vuy.4,p.D200Y|uc003vva.3,p.D148Y|ENST00000263545,p.D200Y|uc011kqt.3,p.D267Y|ENST00000541515,p.D267Y|NM_016019,p.D201Y|NM_001244585,p.D198Y|NM_001244584,p.D267Y|ENST00000541170,p.D198Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kqt.3	nonsynonymous SNV	exon7	c.G799T	p.D267Y	VCEVCSAYLGLHDNDRRLADHFGGK	VCEVCSAYLGLHYNDRRLADHFGGK	10.0	9.0	-	-	3879_7:139092010-139092010 G>T_VCEVCSAYLGLHYNDRRLADHFGGK	0.0
X:53228250-53228250 C>T	1.0	4245	COLORECTAL	-	-	-	1	KDM5C	ENST00000375379,p.A718T|ENST00000404049,p.A717T|NM_001146702,p.A651T|uc004drz.3,p.A718T|uc004dsa.3,p.A717T|NM_001282622,p.A717T|uc022bxe.1,p.A651T|ENST00000452825,p.A651T|ENST00000375401,p.A718T|ENST00000375383,p.A677T|NM_004187,p.A718T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022bxe.1	nonsynonymous SNV	exon13	c.G1951A	p.A651T	QCIKCKTTCFLSALACYDCPDGLVC	QCIKCKTTCFLSTLACYDCPDGLVC	9.0	1.0	-	-	4245_X:53228250-53228250 C>T_QCIKCKTTCFLSTLACYDCPDGLVC	0.0
2:85777099-85777099 A>T	1.0	4078	GASTRIC	-	-	-	-	GGCX	ENST00000233838,p.N745K|uc002sps.3,p.N745K|uc010yss.2,p.N561K|NM_000821,p.N745K|ENST00000430215,p.N688K|uc010yst.2,p.N688K|NM_001142269,p.N688K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010yst.2	nonsynonymous SNV	exon14	c.T2064A	p.N688K	ELNPSNTDSSHSNPPESNPDPVHSE	ELNPSNTDSSHSKPPESNPDPVHSE	7.0	9.0	-	-	4078_2:85777099-85777099 A>T_ELNPSNTDSSHSKPPESNPDPVHSE	0.0
12:104459948-104459948 C>T	0.0	4081	COLORECTAL	-	-	ID=COSM1358319;OCCURENCE=1(large_intestine)	-	HCFC2	NM_013320,p.T56M|uc001tkj.4,p.T56M|ENST00000229330,p.T56M|ENST00000544223,p.T56M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001tkj.4	nonsynonymous SNV	exon2	c.C167T	p.T56M	GIADELHVYNTATNQWFLPAVRGDI	GIADELHVYNTAMNQWFLPAVRGDI	6.0	10.0	-	-	4081_12:104459948-104459948 C>T_GIADELHVYNTAMNQWFLPAVRGDI	0.0
16:27784457-27784457 C>A	1.0	4266	COLORECTAL	-	-	-	-	KIAA0556	uc002dow.3,p.D1412E|ENST00000261588,p.D1412E|NM_015202,p.D1412E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dow.3	nonsynonymous SNV	exon23	c.C4236A	p.D1412E	FIFQFQLLTSWGDPYYIGLTGLELY	FIFQFQLLTSWGEPYYIGLTGLELY	8.0	1.0	-	-	4266_16:27784457-27784457 C>A_FIFQFQLLTSWGEPYYIGLTGLELY	0.0
12:122709069-122709069 G>A	1.0	4252	COLORECTAL	-	-	-	-	DIABLO	NM_001278342,p.P58L|ENST00000353548,p.P58L|ENST00000413918,p.P58L|uc010tad.2,p.P58L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tad.2	nonsynonymous SNV	exon3	c.C173T	p.P58L	VTIGFGVTLCAVPIAQAVYTLTSLY	VTIGFGVTLCAVLIAQAVYTLTSLY	10.0	8.0	-	-	4252_12:122709069-122709069 G>A_VTIGFGVTLCAVLIAQAVYTLTSLY	0.0
22:41572907-41572907 G>A	0.0	4186	BREAST	-	-	-	1	EP300	ENST00000263253,p.R1731H|uc003azl.4,p.R1731H|NM_001429,p.R1731H	protein_coding	uc003azl.4	nonsynonymous SNV	exon31	c.G5192A	p.R1731H	QQAAATQSPGDSRRLSIQRCIQSLV	QQAAATQSPGDSHRLSIQRCIQSLV	4.0	9.0	-	-	4186_22:41572907-41572907 G>A_QQAAATQSPGDSHRLSIQRCIQSLV	0.0
18:6311570-6311570 C>T	1.0	2369	MELANOMA	-	-	-	-	L3MBTL4	ENST00000583054,p.D19N|ENST00000284898,p.D19N|ENST00000400104,p.D19N|uc010dkt.3,p.D19N|uc002kmz.4,p.D19N|ENST00000317931,p.D19N|ENST00000583809,p.D19N|uc002kmy.4,p.D19N|ENST00000581231,p.D19N|NM_173464,p.D19N|ENST00000400105,p.D19N	protein_coding, processed_transcript	uc010dkt.3	nonsynonymous SNV	exon3	c.G55A	p.D19N	KRKLNMDSKERLDQDGRLEQAEEEK	KRKLNMDSKERLNQDGRLEQAEEEK	6.0	7.0	-	-	2369_18:6311570-6311570 C>T_KRKLNMDSKERLNQDGRLEQAEEEK	0.0
11:71850744-71850744 A>T	1.0	4046	OVARIAN	-	-	-	-	FOLR3	ENST00000442948,p.S202C|ENST00000445078,p.S243C|uc001ory.1,p.S245C|ENST00000456237,p.S245C	retained_intron, protein_coding, nonsense_mediated_decay	uc001ory.1	nonsynonymous SNV	exon5	c.A733T	p.S245C	GLWSHSFKVSNYSRGSGRCIQMWFD	GLWSHSFKVSNYCRGSGRCIQMWFD	9.0	5.0	-	-	4046_11:71850744-71850744 A>T_GLWSHSFKVSNYCRGSGRCIQMWFD	0.0
6:161488276-161488276 C>T	1.0	4000	MELANOMA	-	-	-	-	MAP3K4	uc011ega.2,p.S5F|NM_001291958,p.S5F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ega.2	nonsynonymous SNV	exon4	c.C14T	p.S5F	MYIGSIQKDRTTRSRDG	MYIGFIQKDRTTRSRDG	7.0	4.0	-	-	4000_6:161488276-161488276 C>T_MYIGFIQKDRTTRSRDG	0.0
18:45566986-45566986 C>T	0.0	4301	MELANOMA	-	-	ID=COSM988701;OCCURENCE=1(endometrium)	-	ZBTB7C	uc010doo.1,p.D165N|ENST00000588982,p.D165N|ENST00000332053,p.D165N|ENST00000586438,p.D165N|uc010doc.1,p.D174N|uc010don.1,p.D173N|NM_001039360,p.D165N|uc010dnu.3,p.D174N|uc010dob.1,p.D165N|uc010dor.1,p.D187N|uc010doi.1,p.D165N|uc010dnz.1,p.D187N|uc010dog.1,p.D165N|uc010doh.1,p.D174N|uc010dop.1,p.D165N|uc010dos.1,p.D165N|uc002ldb.3,p.D165N|uc010dod.1,p.D187N|uc010dok.1,p.D214N|uc010doe.1,p.D165N|uc010dot.1,p.D165N|ENST00000590800,p.D165N|uc010doa.1,p.D187N|uc010dnw.3,p.D165N|uc010dny.1,p.D165N|uc010dnx.1,p.D165N|uc010dou.1,p.D174N|uc010doj.1,p.D174N|uc010dof.1,p.D165N|ENST00000535628,p.D165N|uc010dom.1,p.D174N|uc010dol.1,p.D174N|uc010doq.1,p.D174N|uc010dnv.3,p.D187N	protein_coding	uc010dou.1	nonsynonymous SNV	exon6	c.G520A	p.D174N	DEEEEEEEEEDDDDDTEDFADQENL	DEEEEEEEEEDDNDDTEDFADQENL	5.0	7.0	-	-	4301_18:45566986-45566986 C>T_DEEEEEEEEEDDNDDTEDFADQENL	0.0
15:27128535-27128535 C>T	0.0	4081	COLORECTAL	-	-	ID=COSM281290;OCCURENCE=1(large_intestine)	-	GABRA5	ENST00000555182,p.R78W|ENST00000400081,p.R110W|uc001zbd.2,p.R110W|ENST00000554596,p.R110W|ENST00000335625,p.R110W|NM_001165037,p.R110W|NM_000810,p.R110W|uc021sgi.1,p.R110W|ENST00000355395,p.R110W|ENST00000554599,p.R110W	protein_coding, processed_transcript	uc021sgi.1	nonsynonymous SNV	exon6	c.C328T	p.R110W	VFFRQSWKDERLRFKGPMQRLPLNN	VFFRQSWKDERLWFKGPMQRLPLNN	1.0	4.0	-	-	4081_15:27128535-27128535 C>T_VFFRQSWKDERLWFKGPMQRLPLNN	0.0
4:1985834-1985834 G>C	1.0	4320	COLORECTAL	-	-	-	-	NELFA	ENST00000411638,p.S348C|ENST00000416258,p.S352C|NM_005663,p.S359C|uc003gen.3,p.S213C|uc003gel.3,p.S273C|uc003gek.3,p.S85C|ENST00000542778,p.S213C|uc003gem.3,p.S359C|ENST00000382882,p.S359C	retained_intron, protein_coding, nonsense_mediated_decay	uc003gen.3	nonsynonymous SNV	exon8	c.C638G	p.S213C	SYIPSSETPPAPSSREASRPPEEPS	SYIPSSETPPAPCSREASRPPEEPS	6.0	7.0	-	-	4320_4:1985834-1985834 G>C_SYIPSSETPPAPCSREASRPPEEPS	0.0
10:50085167-50085167 A>C	0.0	4078	GASTRIC	-	-	-	-	WDFY4	ENST00000325239,p.S2364R|NM_020945,p.S2364R|uc001jha.4,p.S2364R	protein_coding, processed_transcript	uc001jha.4	nonsynonymous SNV	exon43	c.A7090C	p.S2364R	CTQLTFFPALHESLHSEDFLELCRE	CTQLTFFPALHERLHSEDFLELCRE	5.0	8.0	-	-	4078_10:50085167-50085167 A>C_CTQLTFFPALHERLHSEDFLELCRE	0.0
16:83636101-83636101 G>A	1.0	3713	MELANOMA	-	-	-	-	CDH13	uc010vns.2,p.D382N|NM_001220488,p.D382N|uc010vnt.2,p.D81N|NM_001220490,p.D81N|uc010vnu.2,p.D296N|NM_001220489,p.D296N|uc002fgx.3,p.D335N|ENST00000268613,p.D382N|NM_001257,p.D335N|ENST00000428848,p.D296N|ENST00000566620,p.D335N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vnu.2	nonsynonymous SNV	exon7	c.G886A	p.D296N	ENPKYELIIEAQDMAGLDVGLTGTA	ENPKYELIIEAQNMAGLDVGLTGTA	3.0	7.0	-	-	3713_16:83636101-83636101 G>A_ENPKYELIIEAQNMAGLDVGLTGTA	0.0
16:2817179-2817179 T>C	1.0	4196	COLORECTAL	-	-	-	-	SRRM2	ENST00000301740,p.L2217P|uc002crl.1,p.L2217P|uc002crj.1,p.L2121P|uc010bsu.1,p.L2121P|NM_016333,p.L2217P|uc002crk.3,p.L2217P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010bsu.1	nonsynonymous SNV	exon10	c.T6362C	p.L2121P	AARMSQVPAPVPLMSLRTAPAANLA	AARMSQVPAPVPPMSLRTAPAANLA	10.0	4.0	-	-	4196_16:2817179-2817179 T>C_AARMSQVPAPVPPMSLRTAPAANLA	0.0
22:21344786-21344786 C>T	1.0	3713	MELANOMA	-	-	-	1	LZTR1	uc011ahy.2,p.L236F|ENST00000215739,p.L255F|NM_006767,p.L255F|ENST00000389355,p.L236F|uc002zto.3,p.L255F|uc010gsr.1,p.L126F|uc002ztn.3,p.L214F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ahy.2	nonsynonymous SNV	exon7	c.C706T	p.L236F	FSGQSGAKITNNLFQFEFKDKTWTR	FSGQSGAKITNNFFQFEFKDKTWTR	10.0	6.0	-	-	3713_22:21344786-21344786 C>T_FSGQSGAKITNNFFQFEFKDKTWTR	0.0
X:107841965-107841965 C>T	1.0	3879	MELANOMA	-	-	-	-	COL4A5	uc004eob.1,p.P213S|ENST00000328300,p.P605S|ENST00000361603,p.P605S|uc022ccg.2,p.P605S|uc004enz.2,p.P605S|NM_000495,p.P605S	retained_intron, protein_coding, processed_transcript	uc022ccg.2	nonsynonymous SNV	exon25	c.C1813T	p.P605S	PGGITFKGERGPPGNPGLPGLPGNI	PGGITFKGERGPSGNPGLPGLPGNI	8.0	10.0	-	-	3879_X:107841965-107841965 C>T_PGGITFKGERGPSGNPGLPGLPGNI	0.0
14:65263283-65263283 C>T	0.0	4095	COLORECTAL	-	-	-	-	SPTB	ENST00000542895,p.V445M|ENST00000389721,p.V445M|ENST00000389720,p.V445M|ENST00000556626,p.V445M|NM_000347,p.V445M|NM_001024858,p.V445M|uc001xhs.3,p.V445M|uc001xhu.3,p.V445M|uc001xht.3,p.V445M|ENST00000389722,p.V445M|uc001xhr.3,p.V445M	retained_intron, protein_coding, processed_transcript	uc001xhu.3	nonsynonymous SNV	exon11	c.G1333A	p.V445M	MRETWLSENQRLVAQDNFGYDLAAV	MRETWLSENQRLMAQDNFGYDLAAV	4.0	7.0	-	-	4095_14:65263283-65263283 C>T_MRETWLSENQRLMAQDNFGYDLAAV	0.0
11:772466-772466 C>G	1.0	4126	NSCLC	-	-	-	-	PDDC1	ENST00000442059,p.E87D|uc010qwq.1,p.E51D|ENST00000526325,p.E137D|uc010qwr.1,p.E137D|ENST00000528309,p.E75D|NM_182612,p.E137D|ENST00000354286,p.E101D|ENST00000526650,p.E61D|uc001lrf.1,p.E101D|uc001lrd.3,p.E137D|uc001lrc.3,p.E137D|uc010qws.1,p.E87D|uc009ycg.3,p.E87D|ENST00000397472,p.E137D|ENST00000319863,p.E137D|uc010qwp.1,p.E101D|uc010qwm.2,p.E87D|uc021qbo.1,p.E87D|ENST00000524550,p.E101D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021qbo.1	nonsynonymous SNV	exon4	c.G261C	p.E87D	GHGVAALCCATNEDRSWVFDSYSLT	GHGVAALCCATNDDRSWVFDSYSLT	7.0	2.0	-	-	4126_11:772466-772466 C>G_GHGVAALCCATNDDRSWVFDSYSLT	0.0
X:119388799-119388799 G>A	0.0	4158	COLORECTAL	-	-	-	-	ZBTB33	uc022cdm.1,p.R510Q|NM_001184742,p.R510Q|uc004esn.1,p.R510Q|ENST00000326624,p.R510Q|NM_006777,p.R510Q|uc010nqm.1,p.R510Q|ENST00000557385,p.R510Q	protein_coding	uc022cdm.1	nonsynonymous SNV	exon1	c.G1529A	p.R510Q	VCKRSYVCLTSLRRHFNIHSWEKKY	VCKRSYVCLTSLQRHFNIHSWEKKY	7.0	7.0	-	-	4158_X:119388799-119388799 G>A_VCKRSYVCLTSLQRHFNIHSWEKKY	0.0
4:108866527-108866527 C>T	1.0	3713	MELANOMA	-	-	-	-	CYP2U1	uc003hyp.3,p.L298F|ENST00000332884,p.L298F|uc011cfi.2,p.L89F|NM_183075,p.L298F|ENST00000508453,p.L89F	protein_coding, processed_transcript	uc011cfi.2	nonsynonymous SNV	exon4	c.C265T	p.L89F	ELRQIEKDITSFLKKIIKDHQESLD	ELRQIEKDITSFFKKIIKDHQESLD	8.0	5.0	-	-	3713_4:108866527-108866527 C>T_ELRQIEKDITSFFKKIIKDHQESLD	0.0
13:102359130-102359130 G>C	0.0	4259	COLORECTAL	-	-	-	-	ITGBL1	uc010agb.4,p.R337P|NM_001271754,p.R245P|ENST00000545560,p.R245P|NM_001271755,p.R337P|uc001vpc.5,p.R245P|NM_004791,p.R386P|NM_001271756,p.R293P|ENST00000376180,p.R386P|ENST00000376162,p.R293P|uc001vpb.4,p.R386P|uc031qnc.1,p.R293P	protein_coding, processed_transcript	uc031qnc.1	nonsynonymous SNV	exon8	c.G878C	p.R293P	VVCGGHGTCSCGRCVCERGWFGKLC	VVCGGHGTCSCGPCVCERGWFGKLC	7.0	6.0	-	-	4259_13:102359130-102359130 G>C_VVCGGHGTCSCGPCVCERGWFGKLC	0.0
6:154489119-154489119 C>T	0.0	4259	COLORECTAL	-	-	-	-	IPCEF1	ENST00000367220,p.R347Q|NM_015553,p.R346Q|NM_001130700,p.R347Q|uc003qpw.3,p.R347Q|uc003qpx.3,p.R346Q|uc010kjh.3,p.R347Q|NM_001130699,p.R347Q|ENST00000519344,p.R318Q|ENST00000265198,p.R346Q|uc003qpv.3,p.R217Q|uc021zhc.1,p.R808Q|ENST00000422970,p.R347Q	retained_intron, protein_coding, processed_transcript	uc021zhc.1	nonsynonymous SNV	exon21	c.G2423A	p.R808Q	STKKELRKSFVKRCKNPSINEKLHK	STKKELRKSFVKQCKNPSINEKLHK	4.0	6.0	-	-	4259_6:154489119-154489119 C>T_STKKELRKSFVKQCKNPSINEKLHK	0.0
1:35227318-35227318 G>A	0.0	3795	MELANOMA	-	-	-	-	GJB4	uc001bxw.4,p.D155N|NM_153212,p.D155N|ENST00000339480,p.D155N|uc001bxv.1,p.D155N	protein_coding	uc001bxw.4	nonsynonymous SNV	exon1	c.G463A	p.D155N	AGFLYIFHRLYKDYDMPRVVACSVE	AGFLYIFHRLYKNYDMPRVVACSVE	1.0	9.0	-	-	3795_1:35227318-35227318 G>A_AGFLYIFHRLYKNYDMPRVVACSVE	0.0
10:112356189-112356189 G>A	0.0	4110	BILE DUCT	-	-	-	-	SMC3	ENST00000361804,p.G666E|NM_005445,p.G666E|uc001kze.3,p.G666E	protein_coding, processed_transcript	uc001kze.3	nonsynonymous SNV	exon19	c.G1997A	p.G666E	EGDQVSHRGALTGGYYDTRKSRLEL	EGDQVSHRGALTEGYYDTRKSRLEL	8.0	6.0	-	-	4110_10:112356189-112356189 G>A_EGDQVSHRGALTEGYYDTRKSRLEL	0.0
4:20597363-20597363 G>A	1.0	3713	MELANOMA	-	-	ID=COSM108869;OCCURENCE=1(skin)	-	SLIT2	NM_004787,p.D1076N|ENST00000273739,p.D1089N|uc003gpr.1,p.D1076N|ENST00000504154,p.D1076N|NM_001289135,p.D1072N|NM_001289136,p.D1068N|ENST00000503837,p.D1072N|ENST00000503823,p.D1068N|uc003gps.1,p.D1068N	retained_intron, protein_coding, processed_transcript	uc003gps.1	nonsynonymous SNV	exon30	c.G3202A	p.D1068N	CTPGYVGEHCDIDFDDCQDNKCKNG	CTPGYVGEHCDINFDDCQDNKCKNG	3.0	6.0	-	-	3713_4:20597363-20597363 G>A_CTPGYVGEHCDINFDDCQDNKCKNG	0.0
12:69652489-69652489 C>T	1.0	4180	BREAST	-	-	-	-	CPSF6	ENST00000456847,p.R199C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000456847	nonsynonymous SNV	exon6	c.C595T	p.R199C	GPPGAGPPNRGDRPPPPVLFPGQPF	GPPGAGPPNRGDCPPPPVLFPGQPF	10.0	9.0	-	-	4180_12:69652489-69652489 C>T_GPPGAGPPNRGDCPPPPVLFPGQPF	0.0
9:125562624-125562624 G>A	0.0	4329	COLORECTAL	-	-	-	-	OR1K1	ENST00000277309,p.A75T|uc011lze.2,p.A75T|NM_080859,p.A75T	protein_coding	uc011lze.2	nonsynonymous SNV	exon1	c.G223A	p.A75T	LLAHLSFADLCFASVTVPKMLANLL	LLAHLSFADLCFTSVTVPKMLANLL	1.0	9.0	-	-	4329_9:125562624-125562624 G>A_LLAHLSFADLCFTSVTVPKMLANLL	0.0
1:158325101-158325101 A>C	0.0	4235	COLORECTAL	-	-	-	-	CD1E	ENST00000368160,p.I123L|uc001fsf.3,p.I123L|NM_030893,p.I123L|uc001fry.3,p.I123L|NM_001042584,p.I123L|ENST00000434258,p.I121L|NM_001042585,p.I123L|uc001fse.3,p.I123L|ENST00000368167,p.I123L|uc001fsd.3,p.I123L|NM_001042583,p.I123L|uc010pid.2,p.I121L|ENST00000368163,p.I123L|ENST00000368161,p.I123L	protein_coding, processed_transcript	uc010pid.2	nonsynonymous SNV	exon3	c.A361C	p.I121L	SAGQFQLEYPFEIQILAGCRMNAPQ	SAGQFQLEYPFELQILAGCRMNAPQ	2.0	4.0	-	-	4235_1:158325101-158325101 A>C_SAGQFQLEYPFELQILAGCRMNAPQ	0.0
1:22191538-22191538 G>A	0.0	4240	BREAST	-	-	-	-	HSPG2	NM_001291860,p.P1476L|uc009vqd.3,p.P1476L|NM_005529,p.P1475L|uc001bfj.3,p.P1475L|ENST00000374695,p.P1475L	protein_coding, processed_transcript, nonsense_mediated_decay	uc009vqd.3	nonsynonymous SNV	exon36	c.C4427T	p.P1476L	FREEFWRRPDGQPATREHLLMALAD	FREEFWRRPDGQLATREHLLMALAD	9.0	8.0	-	-	4240_1:22191538-22191538 G>A_FREEFWRRPDGQLATREHLLMALAD	0.0
14:105452964-105452964 G>T	1.0	3903	MELANOMA	-	-	-	-	C14orf79	ENST00000389964,p.A66S|uc001ypy.1,p.A66S|NM_174891,p.A66S|ENST00000547315,p.A66S|ENST00000548641,p.A66S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ypy.1	nonsynonymous SNV	exon1	c.G196T	p.A66S	ISMPREGGSTCTARCPDPGEHSSTW	ISMPREGGSTCTSRCPDPGEHSSTW	8.0	8.0	-	-	3903_14:105452964-105452964 G>T_ISMPREGGSTCTSRCPDPGEHSSTW	0.0
7:42004379-42004379 G>A	0.0	4213	COLORECTAL	-	-	-	-	GLI3	ENST00000395925,p.P1431L|NM_000168,p.P1431L|uc011kbh.2,p.P1431L|uc011kbg.2,p.P1372L	retained_intron, protein_coding, processed_transcript	uc011kbh.2	nonsynonymous SNV	exon15	c.C4292T	p.P1431L	NGIKMEMKGQPHPLCSNLQNYSGQF	NGIKMEMKGQPHLLCSNLQNYSGQF	6.0	4.0	-	-	4213_7:42004379-42004379 G>A_NGIKMEMKGQPHLLCSNLQNYSGQF	0.0
22:21990826-21990826 G>A	0.0	3903	MELANOMA	-	-	-	-	CCDC116	uc002zve.3,p.D437N|ENST00000292779,p.D437N|NM_152612,p.D437N	protein_coding	uc002zve.3	nonsynonymous SNV	exon5	c.G1309A	p.D437N	SHFSNRLYEELADFLTQQAASLVIR	SHFSNRLYEELANFLTQQAASLVIR	2.0	9.0	-	-	3903_22:21990826-21990826 G>A_SHFSNRLYEELANFLTQQAASLVIR	0.0
5:140307781-140307781 T>C	0.0	3903	MELANOMA	-	-	-	-	PCDHAC1	ENST00000409700,p.V435A|NM_031882,p.V435A|ENST00000253807,p.V435A|uc003lih.2,p.V435A|NM_018898,p.V435A|uc003lig.1,p.V435A	protein_coding	uc003lih.2	nonsynonymous SNV	exon1	c.T1304C	p.V435A	PPLSTRRTITVSVADVNDNTPNFPQ	PPLSTRRTITVSAADVNDNTPNFPQ	1.0	5.0	-	-	3903_5:140307781-140307781 T>C_PPLSTRRTITVSAADVNDNTPNFPQ	0.0
15:79586571-79586571 G>C	0.0	4186	BREAST	-	-	-	-	ANKRD34C	ENST00000421388,p.E315D|ENST00000558647,p.E315D|NM_001146341,p.E315D|uc021srm.1,p.E315D|uc002bet.3,p.E315D	protein_coding	uc021srm.1	nonsynonymous SNV	exon1	c.G945C	p.E315D	DSKDPTLFHTVTEQVLKIPVSSAPA	DSKDPTLFHTVTDQVLKIPVSSAPA	1.0	9.0	-	-	4186_15:79586571-79586571 G>C_DSKDPTLFHTVTDQVLKIPVSSAPA	0.0
16:69729078-69729078 C>T	1.0	4317	COLORECTAL	-	-	-	-	NFAT5	ENST00000566899,p.P1391L|ENST00000393742,p.P1391L|NM_173214,p.P1391L|NM_138713,p.P1485L|NM_001113178,p.P1484L|uc002exl.2,p.P1485L|NM_138714,p.P1391L|uc002exm.2,p.P1467L|ENST00000565301,p.P77L|uc002exi.3,p.P1391L|ENST00000349945,p.P1391L|NM_006599,p.P1467L|NM_173215,p.P1391L|ENST00000354436,p.P1467L|uc002exn.2,p.P1484L|ENST00000432919,p.P1485L|ENST00000567239,p.P1484L|uc002exj.2,p.P1391L|uc002exk.2,p.P1391L	retained_intron, protein_coding, nonsense_mediated_decay	uc002exn.2	nonsynonymous SNV	exon14	c.C4451T	p.P1484L	CSQLLTSGPATLPDQLMAISQPGQP	CSQLLTSGPATLLDQLMAISQPGQP	10.0	10.0	-	-	4317_16:69729078-69729078 C>T_CSQLLTSGPATLLDQLMAISQPGQP	0.0
19:58578703-58578703 C>T	0.0	4155	MELANOMA	-	-	-	-	ZNF135	ENST00000359978,p.P296L|uc010yhr.2,p.P105L|ENST00000506786,p.P242L|ENST00000401053,p.P308L|uc002qrd.2,p.P296L|ENST00000439855,p.P284L|NM_003436,p.P296L|uc002qrg.3,p.P308L|NM_007134,p.P308L|ENST00000313434,p.P284L|NM_001164530,p.P296L|NM_001289402,p.P242L|ENST00000511556,p.P296L|NM_001289401,p.P284L|uc010yhq.2,p.P296L|uc002qrf.3,p.P242L|uc002qre.3,p.P284L	protein_coding, nonsense_mediated_decay	uc010yhr.2	nonsynonymous SNV	exon3	c.C314T	p.P105L	CTQCGRTFNQIAPLIQHQRTHTGEK	CTQCGRTFNQIALLIQHQRTHTGEK	3.0	8.0	-	-	4155_19:58578703-58578703 C>T_CTQCGRTFNQIALLIQHQRTHTGEK	0.0
10:72534084-72534084 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	TBATA	uc010qjm.1,p.T269S|uc010qjn.1,p.T267S|ENST00000299290,p.T268S|uc001jrj.1,p.T268S|NM_152710,p.T268S	protein_coding	uc010qjn.1	nonsynonymous SNV	exon9	c.A799T	p.T267S	PKEKDLALGLLQTAVAQLLPQPLVS	PKEKDLALGLLQSAVAQLLPQPLVS	1.0	9.0	-	-	4258_10:72534084-72534084 T>A_PKEKDLALGLLQSAVAQLLPQPLVS	0.0
X:153008476-153008476 T>C, X:153008483-153008483 G>A	0.0	4301	MELANOMA	-	-	-	-	ABCD1	uc004fif.2,p.S606P|NM_000033,p.S606P|ENST00000218104,p.S606P	protein_coding	uc004fif.2	nonsynonymous SNV	exon8	c.T1816C, c.G1823A	p.S606P, p.G608D	GWEAMCDWKDVLSGGEKQRIGMARM	GWEAMCDWKDVLPGDEKQRIGMARM	7.0	3.0	-	Additional variant within 36 nucleotides, X:153008483-153008483 G>A, residue 15 G>D PR	4301_X:153008476-153008476 T>C, X:153008483-153008483 G>A_GWEAMCDWKDVLPGDEKQRIGMARM	0.0
5:21760750-21760750 A>C	0.0	4196	COLORECTAL	-	-	-	-	CDH12	NM_004061,p.L517R|ENST00000382254,p.L517R|uc011cno.1,p.L477R|ENST00000504376,p.L517R|uc003jgk.2,p.L517R|ENST00000522262,p.L477R|uc010iuc.2,p.L517R	retained_intron, protein_coding, processed_transcript	uc011cno.1	nonsynonymous SNV	exon10	c.T1430G	p.L477R	QIIQIVSAADRDLSPAGQQFSFRLS	QIIQIVSAADRDRSPAGQQFSFRLS	3.0	4.0	-	-	4196_5:21760750-21760750 A>C_QIIQIVSAADRDRSPAGQQFSFRLS	0.0
7:14216503-14216503 C>T	0.0	4245	COLORECTAL	-	-	-	-	DGKB	uc011jxu.2,p.M755I|ENST00000407950,p.M748I|NM_145695,p.M756I|ENST00000403951,p.M756I|ENST00000402815,p.M755I|ENST00000258767,p.M756I|ENST00000444700,p.M737I|uc003ssz.3,p.M756I|ENST00000399322,p.M756I|NM_004080,p.M756I|uc011jxt.2,p.M737I|ENST00000406247,p.M756I|uc003sta.3,p.M756I	retained_intron, protein_coding, processed_transcript	uc011jxu.2	nonsynonymous SNV	exon24	c.G2265A	p.M755I	SCVVIRTSKSLPMQIDGEPWMQTPC	SCVVIRTSKSLPIQIDGEPWMQTPC	1.0	7.0	-	-	4245_7:14216503-14216503 C>T_SCVVIRTSKSLPIQIDGEPWMQTPC	0.0
6:34386174-34386174 C>T	1.0	4240	BREAST	-	-	-	-	RPS10,RPS10-NUDT3	NM_001204091,p.G143E|uc021yyu.1,p.G143E|NM_001203245,p.G143E|NM_001014,p.G143E|uc003ojn.3,p.G143E|ENST00000326199,p.G143E|uc003ojm.3,p.G143E	protein_coding, processed_transcript	uc021yyu.1	nonsynonymous SNV	exon5	c.G428A	p.G143E	AVPPGADKKAEAGAGSATEFQFRGG	AVPPGADKKAEAEAGSATEFQFRGG	10.0	6.0	CD8	-	4240_6:34386174-34386174 C>T_AVPPGADKKAEAEAGSATEFQFRGG	2.0
14:100380547-100380547 T>A	0.0	4278	COLORECTAL	-	-	-	-	EML1	NM_004434,p.V509E|uc010tww.2,p.V497E|uc001ygr.3,p.V528E|ENST00000262233,p.V509E|uc001ygs.3,p.V509E|ENST00000334192,p.V528E|ENST00000327921,p.V497E|NM_001008707,p.V528E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tww.2	nonsynonymous SNV	exon15	c.T1490A	p.V497E	TEIPEQFGPIRTVAEGKGDVILIGT	TEIPEQFGPIRTEAEGKGDVILIGT	8.0	9.0	-	-	4278_14:100380547-100380547 T>A_TEIPEQFGPIRTEAEGKGDVILIGT	0.0
7:140453136-140453136 A>T	1.0	4244	COLORECTAL	-	-	ID=COSM476;OCCURENCE=3(adrenal_gland),3(urinary_tract),4(genital_tract),7(pancreas),16(liver),68(eye),2(prostate),4161(large_intestine),21(biliary_tract),11(breast),4377(skin),9(small_intestine),1(autonomic_ganglia),20(pituitary),242(ovary),32(soft_tissue),7(testis),459(haematopoietic_and_lymphoid_tissue),9534(thyroid),78(lung),1(meninges),12(upper_aerodigestive_tract),717(NS),15(bone),2(oesophagus),4(stomach),228(central_nervous_system)	1	BRAF	ENST00000288602,p.V600E|uc003vwc.4,p.V600E|ENST00000479537,p.V28E|NM_004333,p.V600E	retained_intron, protein_coding, nonsense_mediated_decay	uc003vwc.4	nonsynonymous SNV	exon15	c.T1799A	p.V600E	LTVKIGDFGLATVKSRWSGSHQFEQ	LTVKIGDFGLATEKSRWSGSHQFEQ	7.0	10.0	-	-	4244_7:140453136-140453136 A>T_LTVKIGDFGLATEKSRWSGSHQFEQ	0.0
11:102668786-102668786 C>G	0.0	4158	COLORECTAL	-	-	-	-	MMP1	uc001phi.2,p.W13S|NM_002421,p.W13S|ENST00000315274,p.W13S	protein_coding	uc001phi.2	nonsynonymous SNV	exon1	c.G38C	p.W13S	MHSFPPLLLLLFWGVVSHSFPATLE	MHSFPPLLLLLFSGVVSHSFPATLE	4.0	8.0	-	-	4158_11:102668786-102668786 C>G_MHSFPPLLLLLFSGVVSHSFPATLE	0.0
20:17640899-17640899 T>G	0.0	3775	CERVICAL	-	-	-	-	RRBP1	uc010zrr.1,p.D85A|uc002wpv.1,p.D85A|ENST00000246043,p.D85A|uc010zrq.1,p.D85A|uc002wpw.1,p.D85A|ENST00000360807,p.D85A|NM_001042576,p.D85A|NM_004587,p.D85A|ENST00000398782,p.D85A|ENST00000377807,p.D85A|ENST00000377813,p.D85A|uc021waw.1,p.D85A	protein_coding, processed_transcript	uc021waw.1	nonsynonymous SNV	exon1	c.A254C	p.D85A	KKKEEKPNGKIPDHDPAPNVTVLLR	KKKEEKPNGKIPAHDPAPNVTVLLR	10.0	4.0	-	-	3775_20:17640899-17640899 T>G_KKKEEKPNGKIPAHDPAPNVTVLLR	0.0
1:181022802-181022802 G>A	1.0	3713	MELANOMA	-	-	-	-	MR1	uc001gos.2,p.R233K|ENST00000367579,p.R280K|NM_001194999,p.R280K|NM_001195000,p.R233K|ENST00000367580,p.R325K|uc001goq.2,p.R325K|ENST00000282990,p.R233K|NM_001531,p.R325K|uc001gor.2,p.R280K	retained_intron, protein_coding, processed_transcript	uc001gos.2	nonsynonymous SNV	exon5	c.G698A	p.R233K	IVLAGVGVLVWRRRPREQNGAIYLP	IVLAGVGVLVWRKRPREQNGAIYLP	6.0	6.0	-	-	3713_1:181022802-181022802 G>A_IVLAGVGVLVWRKRPREQNGAIYLP	0.0
3:121097680-121097680 G>A	0.0	2591	MELANOMA	-	-	ID=COSM1636880;OCCURENCE=1(bone)	-	STXBP5L	NM_014980,p.R789Q|uc003eec.4,p.R789Q|uc011bji.2,p.R765Q|ENST00000273666,p.R789Q|ENST00000471454,p.R765Q|ENST00000492541,p.R789Q|ENST00000472879,p.R765Q	protein_coding, nonsense_mediated_decay	uc011bji.2	nonsynonymous SNV	exon21	c.G2294A	p.R765Q	KVNRWGPGRPPFRKAQSAACMEISL	KVNRWGPGRPPFQKAQSAACMEISL	1.0	10.0	-	-	2591_3:121097680-121097680 G>A_KVNRWGPGRPPFQKAQSAACMEISL	0.0
14:53331331-53331331 A>T	1.0	4155	MELANOMA	-	-	-	-	FERMT2	ENST00000341590,p.Y464N|NM_006832,p.Y464N|uc001xad.3,p.Y464N|uc001xae.3,p.Y464N|ENST00000553373,p.Y464N|uc001xaf.3,p.Y464N|ENST00000395631,p.Y464N|NM_001135000,p.Y464N|NM_001134999,p.Y464N|ENST00000399304,p.Y464N|uc001xac.3,p.Y464N|ENST00000343279,p.Y464N|ENST00000554152,p.Y417N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001xaf.3	nonsynonymous SNV	exon12	c.T1390A	p.Y464N	NEIWLRCDNEKQYAHWMAACRLASK	NEIWLRCDNEKQNAHWMAACRLASK	10.0	8.0	-	-	4155_14:53331331-53331331 A>T_NEIWLRCDNEKQNAHWMAACRLASK	0.0
10:61566739-61566739 T>A	1.0	4317	COLORECTAL	-	-	-	1	CCDC6	uc001jks.4,p.R315S|ENST00000263102,p.R315S|NM_005436,p.R315S	retained_intron, protein_coding	uc001jks.4	nonsynonymous SNV	exon6	c.A945T	p.R315S	RLQRKLQREMERREALCRQLSESES	RLQRKLQREMERSEALCRQLSESES	7.0	3.0	-	-	4317_10:61566739-61566739 T>A_RLQRKLQREMERSEALCRQLSESES	0.0
1:248039709-248039709 C>A	0.0	4281	COLORECTAL	-	-	-	-	TRIM58	NM_015431,p.P460H|uc001ido.3,p.P460H|ENST00000366481,p.P460H	protein_coding	uc001ido.3	nonsynonymous SNV	exon6	c.C1379A	p.P460H	FFICDATPLILPPTTIAGSGNWASR	FFICDATPLILPHTTIAGSGNWASR	2.0	6.0	-	-	4281_1:248039709-248039709 C>A_FFICDATPLILPHTTIAGSGNWASR	0.0
7:116550353-116550353 C>T	1.0	3713	MELANOMA	-	-	-	-	CAPZA2	ENST00000458284,p.L165F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000458284	nonsynonymous SNV	exon6	c.C493T	p.L165F	YNHSFNHSSGWHLENSGSLL	YNHSFNHSSGWHFENSGSLL	9.0	8.0	-	-	3713_7:116550353-116550353 C>T_YNHSFNHSSGWHFENSGSLL	0.0
6:29571438-29571438 C>T	0.0	4345	COLORECTAL	-	-	ID=COSM184854;OCCURENCE=1(large_intestine)	-	GABBR1	uc003nmu.4,p.R861H|ENST00000377016,p.R861H|NM_021904,p.R861H|ENST00000377012,p.R806H|ENST00000377034,p.R923H|uc011dlr.2,p.R746H|uc003nmt.4,p.R923H|uc003nmp.4,p.R806H|ENST00000355973,p.R806H|NM_001470,p.R923H|uc003nms.4,p.R806H|NM_021903,p.R806H	retained_intron, protein_coding, nonsense_mediated_decay	uc011dlr.2	nonsynonymous SNV	exon23	c.G2237A	p.R746H	ELRHQLQSRQQLRSRRHPPTPPEPS	ELRHQLQSRQQLHSRRHPPTPPEPS	5.0	6.0	-	-	4345_6:29571438-29571438 C>T_ELRHQLQSRQQLHSRRHPPTPPEPS	0.0
9:35091403-35091403 C>A	0.0	4298	COLORECTAL	-	-	-	-	PIGO	ENST00000378617,p.Q827H|NM_032634,p.Q827H|uc003zwg.2,p.Q390H|ENST00000341666,p.Q827H|uc003zwd.3,p.Q827H	protein_coding, processed_transcript	uc003zwg.2	nonsynonymous SNV	exon3	c.G1170T	p.Q390H	TKSQGPLTVAAYQLGSVYSAAMVTA	TKSQGPLTVAAYHLGSVYSAAMVTA	7.0	4.0	-	-	4298_9:35091403-35091403 C>A_TKSQGPLTVAAYHLGSVYSAAMVTA	0.0
20:57415359-57415359 C>G	0.0	4240	BREAST	-	-	-	1	GNAS	NM_016592,p.N66K|ENST00000371075,p.N66K|ENST00000313949,p.N66K|uc021wfm.1,p.N66K|uc021wfl.1,p.N66K|ENST00000371098,p.N66K	retained_intron, protein_coding, processed_transcript	uc021wfm.1	nonsynonymous SNV	exon1	c.C198G	p.N66K	QRAAAQQRRSFLNAHHRSGAQVFPE	QRAAAQQRRSFLKAHHRSGAQVFPE	10.0	1.0	-	-	4240_20:57415359-57415359 C>G_QRAAAQQRRSFLKAHHRSGAQVFPE	0.0
2:231937117-231937117 C>T	1.0	4134	NSCLC	-	-	-	-	PSMD1	uc002vrm.2,p.S290L|uc002vrn.2,p.S290L|uc010fxu.2,p.S154L|NM_002807,p.S290L|NM_001191037,p.S290L|ENST00000308696,p.S290L|ENST00000409643,p.S290L|ENST00000373635,p.S290L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010fxu.2	nonsynonymous SNV	exon6	c.C461T	p.S154L	VPGSTNTGTVPGSEKDSDSMETEEK	VPGSTNTGTVPGLEKDSDSMETEEK	10.0	1.0	-	-	4134_2:231937117-231937117 C>T_VPGSTNTGTVPGLEKDSDSMETEEK	0.0
7:88965273-88965273 C>G	0.0	4326	BREAST	-	-	-	-	ZNF804B	NM_181646,p.Q993E|ENST00000333190,p.Q993E|uc011khi.2,p.Q993E	protein_coding	uc011khi.2	nonsynonymous SNV	exon4	c.C2977G	p.Q993E	EKIQYASESRNDQDSAIPRTTEKDK	EKIQYASESRNDEDSAIPRTTEKDK	2.0	9.0	-	-	4326_7:88965273-88965273 C>G_EKIQYASESRNDEDSAIPRTTEKDK	0.0
17:9765348-9765348 A>C	0.0	4326	BREAST	-	-	-	-	GLP2R	NM_004246,p.T333P|ENST00000574745,p.T153P|uc002gmd.1,p.T333P|ENST00000262441,p.T333P	protein_coding, nonsense_mediated_decay	uc002gmd.1	nonsynonymous SNV	exon9	c.A997C	p.T333P	ARAHLENTGCWTTNGNKKIWWIIRG	ARAHLENTGCWTPNGNKKIWWIIRG	3.0	2.0	-	-	4326_17:9765348-9765348 A>C_ARAHLENTGCWTPNGNKKIWWIIRG	0.0
9:91083415-91083415 A>G	1.0	3713	MELANOMA	-	-	ID=COSM1674603;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	SPIN1	uc004apz.3,p.M162V|uc010mqk.3,p.M162V|uc004apy.3,p.M162V|uc010mqj.3,p.M162V|ENST00000541629,p.M162V|ENST00000375859,p.M162V|NM_006717,p.M162V	protein_coding, processed_transcript	uc010mqk.3	nonsynonymous SNV	exon6	c.A484G	p.M162V	EWRGMVLARAPVMNTWFYITYEKDP	EWRGMVLARAPVVNTWFYITYEKDP	9.0	8.0	-	-	3713_9:91083415-91083415 A>G_EWRGMVLARAPVVNTWFYITYEKDP	0.0
9:26935132-26935132 T>C	1.0	4180	BREAST	-	-	-	-	PLAA	ENST00000397292,p.I74M|NM_001031689,p.I74M|uc003zqe.2,p.I74M|ENST00000520884,p.I74M|uc003zqd.3,p.I74M	retained_intron, protein_coding, processed_transcript	uc003zqe.2	nonsynonymous SNV	exon2	c.A222G	p.I74M	SGHSNFVSCVCIIPSSDIYPHGLIA	SGHSNFVSCVCIMPSSDIYPHGLIA	9.0	8.0	-	-	4180_9:26935132-26935132 T>C_SGHSNFVSCVCIMPSSDIYPHGLIA	0.0
19:21476293-21476293 G>A	0.0	4246	COLORECTAL	-	-	-	-	ZNF708	ENST00000356929,p.T492I|uc002npr.1,p.T428I|uc002npq.1,p.T492I|NM_001297560,p.T428I|uc010ecs.1,p.T428I|NM_021269,p.T492I|NM_001297561,p.T428I	protein_coding, nonsense_mediated_decay	uc010ecs.1	nonsynonymous SNV	exon4	c.C1283T	p.T428I	ECGKSFILSSHLTTHKIIHTGEKPY	ECGKSFILSSHLITHKIIHTGEKPY	8.0	9.0	-	-	4246_19:21476293-21476293 G>A_ECGKSFILSSHLITHKIIHTGEKPY	0.0
1:8420238-8420238 G>A	1.0	3713	MELANOMA	-	-	-	-	RERE	ENST00000337907,p.P1110L|ENST00000476556,p.P556L|uc010nzx.1,p.P842L|NM_012102,p.P1110L|uc001ape.3,p.P1110L|NM_001042682,p.P556L|NM_001042681,p.P1110L|uc001apd.3,p.P556L|ENST00000400908,p.P1110L|ENST00000377464,p.P842L|uc001apf.3,p.P1110L	retained_intron, protein_coding, processed_transcript, non_stop_decay	uc010nzx.1	nonsynonymous SNV	exon12	c.C2525T	p.P842L	LDDAEEPESPPPPPRSPSPEPTVVD	LDDAEEPESPPPLPRSPSPEPTVVD	7.0	9.0	-	-	3713_1:8420238-8420238 G>A_LDDAEEPESPPPLPRSPSPEPTVVD	0.0
X:595431-595431 G>A	0.0	4235	COLORECTAL	-	-	-	-	SHOX	uc004cph.1,p.R119H|ENST00000381575,p.R119H|uc004cpi.3,p.R119H|ENST00000334060,p.R119H|NM_006883,p.R119H|ENST00000381578,p.R119H|ENST00000554971,p.R119H|NM_000451,p.R119H	protein_coding, nonsense_mediated_decay	uc004cpi.3	nonsynonymous SNV	exon3	c.G356A	p.R119H	EDEDGQTKLKQRRSRTNFTLEQLNE	EDEDGQTKLKQRHSRTNFTLEQLNE	1.0	9.0	-	-	4235_X:595431-595431 G>A_EDEDGQTKLKQRHSRTNFTLEQLNE	0.0
6:42832567-42832567 C>T	1.0	3713	MELANOMA	-	-	-	-	GLTSCR1L	uc003osp.1,p.H875Y|NM_015349,p.H875Y|ENST00000394168,p.H875Y|ENST00000314073,p.H875Y|uc003osn.1,p.H875Y|uc011duw.1,p.H875Y	protein_coding	uc011duw.1	nonsynonymous SNV	exon12	c.C2623T	p.H875Y	DRAKTGVTEPMNHDQFHLVPNHIVV	DRAKTGVTEPMNYDQFHLVPNHIVV	6.0	9.0	-	-	3713_6:42832567-42832567 C>T_DRAKTGVTEPMNYDQFHLVPNHIVV	0.0
10:14050072-14050072 C>T	0.0	4345	COLORECTAL	-	-	-	-	FRMD4A	uc001imu.1,p.R27H|ENST00000342409,p.R27H	protein_coding, processed_transcript	uc001imu.1	nonsynonymous SNV	exon1	c.G80A	p.R27H	LLLKIPYGSLRRRSVERMTEGRRCQ	LLLKIPYGSLRRHSVERMTEGRRCQ	6.0	10.0	-	-	4345_10:14050072-14050072 C>T_LLLKIPYGSLRRHSVERMTEGRRCQ	0.0
1:230895368-230895368 C>T	0.0	3903	MELANOMA	-	-	-	-	CAPN9	uc001hua.1,p.H132Y|uc001htz.1,p.H132Y|NM_006615,p.H132Y|NM_016452,p.H132Y|ENST00000354537,p.H132Y|ENST00000271971,p.H132Y	protein_coding, processed_transcript	uc001hua.1	nonsynonymous SNV	exon3	c.C394T	p.H132Y	DQSFGPGYAGIFHFQFWQHSEWLDV	DQSFGPGYAGIFYFQFWQHSEWLDV	1.0	7.0	-	-	3903_1:230895368-230895368 C>T_DQSFGPGYAGIFYFQFWQHSEWLDV	0.0
1:39987206-39987206 G>A	1.0	3879	MELANOMA	-	-	-	-	BMP8A	ENST00000331593,p.E278K|uc001cdi.3,p.E278K|NM_181809,p.E278K	protein_coding	uc001cdi.3	nonsynonymous SNV	exon4	c.G832A	p.E278K	RPLRRRQPKKSNELPQANRLPGIFD	RPLRRRQPKKSNKLPQANRLPGIFD	5.0	1.0	-	-	3879_1:39987206-39987206 G>A_RPLRRRQPKKSNKLPQANRLPGIFD	0.0
2:209292995-209292995 G>A	0.0	3903	MELANOMA	-	-	-	-	PTH2R	uc010zjb.2,p.E60K|ENST00000272847,p.E49K|NM_005048,p.E49K|uc002vdb.4,p.E49K	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zjb.2	nonsynonymous SNV	exon2	c.G178A	p.E60K	QIVLVLKAKVQCELNITAQLQEGEG	QIVLVLKAKVQCKLNITAQLQEGEG	1.0	8.0	-	-	3903_2:209292995-209292995 G>A_QIVLVLKAKVQCKLNITAQLQEGEG	0.0
20:5283051-5283051 G>A	0.0	3795	MELANOMA	0.0005	-	-	-	PROKR2	ENST00000546004,p.R264C|uc010zqw.2,p.R264C|uc010zqy.2,p.R264C|NM_144773,p.R264C|ENST00000217270,p.R264C|uc010zqx.2,p.R264C	protein_coding	uc010zqy.2	nonsynonymous SNV	exon3	c.C790T	p.R264C	FKAVPGFQTEQIRKRLRCRRKTVLV	FKAVPGFQTEQICKRLRCRRKTVLV	1.0	6.0	-	-	3795_20:5283051-5283051 G>A_FKAVPGFQTEQICKRLRCRRKTVLV	0.0
10:99118345-99118345 C>G	1.0	4326	BREAST	-	-	-	-	RRP12	ENST00000315563,p.R1147P|uc009xvm.3,p.R965P|ENST00000536831,p.R965P|uc010qou.2,p.R1186P|uc009xvn.3,p.R1147P|uc001knf.3,p.R1247P|NM_001284337,p.R1147P|ENST00000414986,p.R1186P|NM_015179,p.R1247P|NM_001145114,p.R1186P|uc001kne.3,p.R262P|uc009xvl.3,p.R364P|ENST00000370992,p.R1247P	protein_coding, processed_transcript	uc010qou.2	nonsynonymous SNV	exon31	c.G3557C	p.R1186P	AKKAKGDVKKKGRPDPYAYIPLNRS	AKKAKGDVKKKGPPDPYAYIPLNRS	7.0	3.0	-	-	4326_10:99118345-99118345 C>G_AKKAKGDVKKKGPPDPYAYIPLNRS	0.0
19:35793590-35793590 G>A	0.0	4158	COLORECTAL	-	-	-	-	MAG	uc002nyx.2,p.A404T|ENST00000392213,p.A404T|NM_001199216,p.A379T|ENST00000361922,p.A404T|NM_002361,p.A404T|uc002nyz.2,p.A404T|NM_080600,p.A404T|ENST00000537831,p.A379T|uc010eds.2,p.A379T|uc002nyy.2,p.A404T	retained_intron, protein_coding, processed_transcript	uc010eds.2	nonsynonymous SNV	exon7	c.G1135A	p.A379T	CVAENQYGQRATAFNLSVEFAPVLL	CVAENQYGQRATTFNLSVEFAPVLL	3.0	3.0	-	-	4158_19:35793590-35793590 G>A_CVAENQYGQRATTFNLSVEFAPVLL	0.0
X:65476043-65476045 TTG>-	1.0	4287	COLORECTAL	-	-	-	-	HEPH	NM_014799,p.656_656del|NM_001130860,p.926_926del|NM_001282141,p.734_734del|ENST00000419594,p.734_734del|ENST00000374727,p.926_926del|uc004dwo.3,p.656_656del|ENST00000343002,p.923_923del|ENST00000519389,p.977_977del|uc011mpa.2,p.926_926del|ENST00000336279,p.656_656del|uc011moz.2,p.977_977del|uc004dwn.3,p.926_926del|uc010nks.3,p.215_215del|uc010nkr.3,p.734_734del|NM_138737,p.977_977del|ENST00000441993,p.926_926del	retained_intron, protein_coding, nonsense_mediated_decay	uc011mpa.2	nonframeshift deletion	exon16	c.2776_2778del	p.926_926del	HGGRSDMDREFALLFLIFDENKSWY	HGGRSDMDREFALFLIFDENKSWYL	9.0	3.0	-	-	4287_X:65476043-65476045 TTG>-_HGGRSDMDREFALFLIFDENKSWYL	0.0
19:3062756-3062756 C>T	1.0	3716	MELANOMA	-	-	-	-	AES	NM_198969,p.R57Q|ENST00000221561,p.R57Q|uc002lxb.1,p.R57Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002lxb.1	nonsynonymous SNV	exon1	c.G170A	p.R57Q	PGRATAGPAASTRAAGSLFFDRWGN	PGRATAGPAASTQAAGSLFFDRWGN	10.0	8.0	-	-	3716_19:3062756-3062756 C>T_PGRATAGPAASTQAAGSLFFDRWGN	0.0
1:154033515-154033515 G>A	0.0	4301	MELANOMA	-	-	-	-	NUP210L	NM_207308,p.S884F|ENST00000271854,p.S884F|NM_001159484,p.S884F|uc001fdw.3,p.S884F|uc010peh.2,p.S884F|ENST00000368559,p.S884F	protein_coding	uc010peh.2	nonsynonymous SNV	exon19	c.C2651T	p.S884F	VGYSEKKSPKEISNLPRSVDVELLL	VGYSEKKSPKEIFNLPRSVDVELLL	2.0	10.0	-	-	4301_1:154033515-154033515 G>A_VGYSEKKSPKEIFNLPRSVDVELLL	0.0
16:31476373-31476373 C>T	1.0	3713	MELANOMA	-	-	ID=COSN160428;OCCURENCE=1(NS)	-	ARMC5	NM_024742,p.P677S|uc002eca.4,p.P677S|ENST00000457010,p.P677S	retained_intron, protein_coding, nonsense_mediated_decay	uc002eca.4	nonsynonymous SNV	exon4	c.C2029T	p.P677S	SPEWGGEQGVPVPPWAHRQSSAVSS	SPEWGGEQGVPVSPWAHRQSSAVSS	4.0	2.0	-	-	3713_16:31476373-31476373 C>T_SPEWGGEQGVPVSPWAHRQSSAVSS	0.0
13:99340519-99340519 A>T	0.0	4246	COLORECTAL	-	-	-	-	SLC15A1	uc001vno.3,p.Y556N|NM_005073,p.Y556N|ENST00000376503,p.Y556N	protein_coding	uc001vno.3	nonsynonymous SNV	exon20	c.T1666A	p.Y556N	NTFYLEFGSAYTYIVQRKNDSCPEV	NTFYLEFGSAYTNIVQRKNDSCPEV	3.0	5.0	-	-	4246_13:99340519-99340519 A>T_NTFYLEFGSAYTNIVQRKNDSCPEV	0.0
7:116339255-116339255 G>A	1.0	3713	MELANOMA	-	-	-	1	MET	ENST00000436117,p.M39I|uc011knb.1,p.M39I|ENST00000456159,p.M58I|uc011kng.1,p.M39I|uc010lkh.3,p.M39I|uc011knf.2,p.M39I|uc003vij.3,p.M39I|uc010lkg.3,p.M39I|NM_000245,p.M39I|uc011kne.2,p.M39I|uc011kni.2,p.M39I|uc011knh.1,p.M39I|uc011kmz.1,p.M39I|NM_001127500,p.M39I|uc022akk.1,p.M39I|uc011kna.1,p.M39I|uc011knd.2,p.M39I|uc003vii.1,p.M58I|ENST00000397752,p.M39I|ENST00000318493,p.M39I|uc011knc.1,p.M39I	protein_coding, processed_transcript	uc022akk.1	nonsynonymous SNV	exon2	c.G117A	p.M39I	KEALAKSEMNVNMKYQLPNFTAETP	KEALAKSEMNVNIKYQLPNFTAETP	2.0	6.0	-	-	3713_7:116339255-116339255 G>A_KEALAKSEMNVNIKYQLPNFTAETP	0.0
1:28354414-28354414 G>A	1.0	4189	MELANOMA	-	-	-	-	EYA3	ENST00000373871,p.P129S|ENST00000545175,p.P76S|uc010ofs.2,p.P76S|NM_001990,p.P129S|uc001bpi.2,p.P129S|NM_001282562,p.P76S	protein_coding, processed_transcript	uc010ofs.2	nonsynonymous SNV	exon6	c.C226T	p.P76S	LPPFGALWPGMKPESGLIQTPSPSQ	LPPFGALWPGMKSESGLIQTPSPSQ	9.0	8.0	-	-	4189_1:28354414-28354414 G>A_LPPFGALWPGMKSESGLIQTPSPSQ	0.0
7:92733855-92733855 G>T	1.0	4287	COLORECTAL	-	-	-	-	SAMD9	uc022ahg.1,p.S519Y|NM_001193307,p.S519Y|uc003umf.3,p.S519Y|uc003umg.3,p.S519Y|ENST00000379958,p.S519Y|NM_017654,p.S519Y|ENST00000446617,p.S519Y	protein_coding	uc022ahg.1	nonsynonymous SNV	exon1	c.C1556A	p.S519Y	PFDPSSWQRERASDVRKLISFLTHE	PFDPSSWQRERAYDVRKLISFLTHE	7.0	2.0	-	-	4287_7:92733855-92733855 G>T_PFDPSSWQRERAYDVRKLISFLTHE	0.0
22:28193240-28193240 C>T	0.0	3795	MELANOMA	-	-	-	1	MN1	ENST00000302326,p.A1098T|uc003adj.3,p.A1098T|NM_002430,p.A1098T	protein_coding, processed_transcript, nonsense_mediated_decay	uc003adj.3	nonsynonymous SNV	exon1	c.G3292A	p.A1098T	PRGVGAGEHGPKAPPPALGLGIMSN	PRGVGAGEHGPKTPPPALGLGIMSN	4.0	2.0	-	-	3795_22:28193240-28193240 C>T_PRGVGAGEHGPKTPPPALGLGIMSN	0.0
1:92428435-92428435 G>A	0.0	4301	MELANOMA	-	-	-	-	BRDT	uc001dok.4,p.D42N|uc001dol.4,p.D42N|NM_001242807,p.D42N|ENST00000426141,p.D42N|ENST00000450792,p.D42N|uc010otb.2,p.D42N|NM_001242808,p.D42N|NM_001242805,p.D42N|ENST00000423434,p.D42N|ENST00000548992,p.D42N|uc010osz.2,p.D42N|ENST00000440509,p.D42N|ENST00000394530,p.D42N|NM_001242806,p.D42N|ENST00000399546,p.D42N|ENST00000362005,p.D42N|ENST00000402388,p.D42N|uc010ota.2,p.D42N|ENST00000427104,p.D42N|ENST00000448194,p.D42N|NM_207189,p.D42N|uc001dom.4,p.D42N|NM_001726,p.D42N	protein_coding, processed_transcript	uc010otb.2	nonsynonymous SNV	exon2	c.G124A	p.D42N	NQLQYLQKVVLKDLWKHSFSWPFQR	NQLQYLQKVVLKNLWKHSFSWPFQR	2.0	8.0	-	-	4301_1:92428435-92428435 G>A_NQLQYLQKVVLKNLWKHSFSWPFQR	0.0
5:112175193-112175193 C>-	1.0	4196	COLORECTAL	-	-	ID=COSM300845;OCCURENCE=1(large_intestine)	1	APC	ENST00000257430,p.T1301fs|NM_001127511,p.T1283fs|NM_001127510,p.T1301fs|NM_000038,p.T1301fs|uc011cvt.2,p.T1283fs|ENST00000512211,p.T1301fs|ENST00000508376,p.T1301fs|uc010jbz.3,p.T1018fs|ENST00000457016,p.T1301fs|uc003kpz.4,p.T1301fs|uc003kpy.4,p.T1301fs|uc010jca.3,p.T601fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cvt.2	frameshift deletion	exon14	c.3848delC	p.T1283fs	CNQTTQEADSANTLQIAEIKEKIGT	CNQTTQEADSANTCK	9.0	8.0	-	-	4196_5:112175193-112175193 C>-_CNQTTQEADSANTCK	0.0
1:111060362-111060362 G>A	0.0	4298	COLORECTAL	0.0005	-	-	-	KCNA10	ENST00000369771,p.R350C|uc001dzt.1,p.R350C|NM_005549,p.R350C	protein_coding	uc001dzt.1	nonsynonymous SNV	exon1	c.C1048T	p.R350C	AILRIIRLVRVFRIFKLSRHSKGLQ	AILRIIRLVRVFCIFKLSRHSKGLQ	1.0	10.0	-	-	4298_1:111060362-111060362 G>A_AILRIIRLVRVFCIFKLSRHSKGLQ	0.0
8:116599500-116599500 C>A	0.0	4258	ENDOMETRIAL	-	-	-	-	TRPS1	ENST00000395715,p.A810S|NM_001282903,p.A803S|uc011lhy.2,p.A801S|ENST00000220888,p.A797S|NM_014112,p.A810S|uc010mcy.3,p.A797S|NM_001282902,p.A801S|uc003ynz.3,p.A797S|ENST00000519076,p.A551S|ENST00000519674,p.A797S|ENST00000520276,p.A801S|ENST00000517323,p.A601S|uc003yny.3,p.A810S	protein_coding, nonsense_mediated_decay	uc011lhy.2	nonsynonymous SNV	exon4	c.G2401T	p.A801S	SSDDLRNVTWRGADILRGSPSYTQA	SSDDLRNVTWRGSDILRGSPSYTQA	7.0	6.0	-	-	4258_8:116599500-116599500 C>A_SSDDLRNVTWRGSDILRGSPSYTQA	0.0
18:71797657-71797657 G>A	0.0	4266	COLORECTAL	-	-	-	-	FBXO15	NM_152676,p.A114V|ENST00000419743,p.A190V|ENST00000269500,p.A114V|NM_001142958,p.A190V|uc002lle.2,p.A114V|uc002llf.2,p.A190V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002llf.2	nonsynonymous SNV	exon4	c.C569T	p.A190V	NPYTGLPVKTKEALRIFGLGWAIIL	NPYTGLPVKTKEVLRIFGLGWAIIL	3.0	2.0	-	-	4266_18:71797657-71797657 G>A_NPYTGLPVKTKEVLRIFGLGWAIIL	0.0
4:90816156-90816156 A>T	0.0	4258	ENDOMETRIAL	-	-	-	-	MMRN1	uc010iku.3,p.S12C|ENST00000394981,p.S12C|uc003hst.3,p.S12C|NM_007351,p.S12C|ENST00000264790,p.S12C|ENST00000394980,p.S12C	retained_intron, protein_coding	uc010iku.3	nonsynonymous SNV	exon1	c.A34T	p.S12C	MKGARLFVLLSSLWSGGIGLNNSK	MKGARLFVLLSCLWSGGIGLNNSK	3.0	10.0	-	-	4258_4:90816156-90816156 A>T_MKGARLFVLLSCLWSGGIGLNNSK	0.0
13:36367569-36367569 C>G	0.0	4316	COLORECTAL	-	-	-	-	DCLK1	ENST00000255448,p.K664N|NM_004734,p.K664N|NM_001195415,p.K357N|uc001uve.4,p.K357N|uc010teh.2,p.K357N|uc001uvf.3,p.K664N|ENST00000379893,p.K357N|ENST00000360631,p.K664N|uc010abk.3,p.K184N|NM_001195416,p.K357N	protein_coding, processed_transcript	uc010teh.2	nonsynonymous SNV	exon12	c.G1071C	p.K357N	LPENEHQLSVAGKIKKHFNTGPKPN	LPENEHQLSVAGNIKKHFNTGPKPN	2.0	5.0	-	-	4316_13:36367569-36367569 C>G_LPENEHQLSVAGNIKKHFNTGPKPN	0.0
19:18245518-18245518 G>C	1.0	4252	COLORECTAL	-	-	-	-	MAST3	NM_015016,p.K538N|ENST00000262811,p.K538N|uc002nhz.4,p.K538N	retained_intron, protein_coding	uc002nhz.4	nonsynonymous SNV	exon15	c.G1614C	p.K538N	GHIEKDAREFIDKQVCGTPEYIAPE	GHIEKDAREFIDNQVCGTPEYIAPE	7.0	8.0	-	-	4252_19:18245518-18245518 G>C_GHIEKDAREFIDNQVCGTPEYIAPE	0.0
14:95932330-95932330 C>T	0.0	4235	COLORECTAL	0.0005	-	-	-	SYNE3	uc001yej.1,p.V189M|uc010avi.3,p.V189M|ENST00000557275,p.V189M|ENST00000553340,p.V189M|uc001yei.4,p.V189M|ENST00000334258,p.V189M|NM_152592,p.V189M	retained_intron, protein_coding	uc010avi.3	nonsynonymous SNV	exon3	c.G565A	p.V189M	AASLFNRIGDPSVDEDAQKRMKAEY	AASLFNRIGDPSMDEDAQKRMKAEY	4.0	6.0	-	-	4235_14:95932330-95932330 C>T_AASLFNRIGDPSMDEDAQKRMKAEY	0.0
10:98714868-98714868 T>G	1.0	4301	MELANOMA	-	-	-	-	LCOR	ENST00000356016,p.L164R|uc001kms.2,p.L164R|ENST00000371097,p.L164R|NM_032440,p.L164R|NM_001170766,p.L164R|ENST00000371103,p.L164R|ENST00000540664,p.L164R|uc001kmr.3,p.L164R|NM_001170765,p.L164R|uc001kmu.2,p.L164R	protein_coding, processed_transcript	uc001kmu.2	nonsynonymous SNV	exon8	c.T491G	p.L164R	PLARSLQISEELLSRNQLSTAASLG	PLARSLQISEELRSRNQLSTAASLG	8.0	3.0	-	-	4301_10:98714868-98714868 T>G_PLARSLQISEELRSRNQLSTAASLG	0.0
4:57876584-57876584 C>T	1.0	3713	MELANOMA	-	-	-	-	POLR2B	uc011caf.1,p.P413S|uc011cae.1,p.P481S|ENST00000431623,p.P413S|ENST00000381227,p.P488S|NM_000938,p.P488S|ENST00000314595,p.P488S|uc003hcl.1,p.P488S|ENST00000441246,p.P481S	retained_intron, protein_coding, processed_transcript	uc011caf.1	nonsynonymous SNV	exon10	c.C1237T	p.P413S	ASTLSHLRRLNSPIGRDGKLAKPRQ	ASTLSHLRRLNSSIGRDGKLAKPRQ	9.0	6.0	-	-	3713_4:57876584-57876584 C>T_ASTLSHLRRLNSSIGRDGKLAKPRQ	0.0
16:30991504-30991504 T>G	1.0	4000	MELANOMA	-	-	-	-	SETD1A	ENST00000262519,p.V1466G|NM_014712,p.V1466G|uc002ead.1,p.V1466G	protein_coding	uc002ead.1	nonsynonymous SNV	exon14	c.T4397G	p.V1466G	TSGADWLNDTHWVHHTITNLTTPKR	TSGADWLNDTHWGHHTITNLTTPKR	6.0	10.0	-	-	4000_16:30991504-30991504 T>G_TSGADWLNDTHWGHHTITNLTTPKR	0.0
7:143556243-143556243 C>A	0.0	4275	COLORECTAL	-	-	-	-	FAM115A	ENST00000355951,p.A727S|uc011ktu.2,p.A303S|ENST00000479870,p.A727S|uc003wdo.2,p.A727S|NM_001206941,p.A303S|NM_014719,p.A727S|NM_001206938,p.A727S|uc003wdp.2,p.A727S	protein_coding, processed_transcript	uc011ktu.2	nonsynonymous SNV	exon6	c.G907T	p.A303S	VADVQISVGWMHAGYPIMCHLESVQ	VADVQISVGWMHSGYPIMCHLESVQ	9.0	2.0	-	-	4275_7:143556243-143556243 C>A_VADVQISVGWMHSGYPIMCHLESVQ	0.0
19:4013176-4013176 G>A	1.0	4095	COLORECTAL	-	-	-	-	PIAS4	uc002lzg.3,p.A95T|ENST00000262971,p.A95T|NM_015897,p.A95T	retained_intron, protein_coding, processed_transcript	uc002lzg.3	nonsynonymous SNV	exon2	c.G283A	p.A95T	PLTMHSTYDRAGAVPRTPLAGPNID	PLTMHSTYDRAGTVPRTPLAGPNID	9.0	7.0	-	-	4095_19:4013176-4013176 G>A_PLTMHSTYDRAGTVPRTPLAGPNID	0.0
19:58491633-58491633 G>A	1.0	2369	MELANOMA	-	-	-	-	ZNF606	uc010yhp.2,p.L49F|uc002qqw.3,p.L139F|ENST00000536132,p.L49F|ENST00000341164,p.L139F|ENST00000551380,p.L139F|NM_025027,p.L139F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yhp.2	nonsynonymous SNV	exon6	c.C145T	p.L49F	CPQRTCPEWVRNLESKALIPAQSIF	CPQRTCPEWVRNFESKALIPAQSIF	6.0	7.0	-	-	2369_19:58491633-58491633 G>A_CPQRTCPEWVRNFESKALIPAQSIF	0.0
14:81953756-81953756 C>G	1.0	4335	COLORECTAL	-	-	ID=COSM1225109;OCCURENCE=1(large_intestine)	-	SEL1L	NM_005065,p.R537P|uc010tvv.2,p.R537P|ENST00000336735,p.R537P	retained_intron, protein_coding	uc010tvv.2	nonsynonymous SNV	exon16	c.G1610C	p.R537P	LAQMHASGTGVMRSCHTAVELFKNV	LAQMHASGTGVMPSCHTAVELFKNV	8.0	8.0	-	-	4335_14:81953756-81953756 C>G_LAQMHASGTGVMPSCHTAVELFKNV	0.0
8:88885470-88885470 G>A	0.0	4235	COLORECTAL	-	-	-	-	DCAF4L2	ENST00000319675,p.R244C|uc003ydz.3,p.R244C|NM_152418,p.R244C	protein_coding	uc003ydz.3	nonsynonymous SNV	exon1	c.C730T	p.R244C	FAIMTPLLFNGCRSGEIFGIDLRCG	FAIMTPLLFNGCCSGEIFGIDLRCG	1.0	2.0	-	-	4235_8:88885470-88885470 G>A_FAIMTPLLFNGCCSGEIFGIDLRCG	0.0
5:140011962-140011962 C>T	1.0	4186	BREAST	-	-	-	-	CD14	NM_001040021,p.D203N|ENST00000302014,p.D203N|NM_000591,p.D203N|uc021yej.1,p.D203N|uc003lgi.2,p.D203N|NM_001174105,p.D203N|NM_001174104,p.D203N|uc021yek.1,p.D203N|uc003lgj.2,p.D203N|ENST00000401743,p.D203N|uc021yel.1,p.D72N	protein_coding	uc021yel.1	nonsynonymous SNV	exon1	c.G214A	p.D72N	RAFPALTSLDLSDNPGLGERGLMAA	RAFPALTSLDLSNNPGLGERGLMAA	9.0	5.0	-	-	4186_5:140011962-140011962 C>T_RAFPALTSLDLSNNPGLGERGLMAA	0.0
1:229730481-229730481 A>T	1.0	4345	COLORECTAL	-	-	-	-	TAF5L	uc001htq.3,p.S445T|NM_014409,p.S445T|ENST00000258281,p.S445T|ENST00000366676,p.S445T	protein_coding, processed_transcript	uc001htq.3	nonsynonymous SNV	exon5	c.T1333A	p.S445T	KFHPNSNYLATGSTDKTVRLWSAQQ	KFHPNSNYLATGTTDKTVRLWSAQQ	6.0	2.0	-	-	4345_1:229730481-229730481 A>T_KFHPNSNYLATGTTDKTVRLWSAQQ	0.0
1:160326901-160326901 G>C	1.0	4335	COLORECTAL	-	-	-	-	NCSTN	NM_001290186,p.R484P|uc010pjf.2,p.R484P|ENST00000294785,p.R622P|ENST00000535857,p.R484P|uc010pjg.2,p.R364P|ENST00000368065,p.R364P|ENST00000368063,p.R602P|ENST00000392212,p.R602P|uc001fvx.3,p.R622P|NM_001290184,p.R602P|NM_015331,p.R622P|uc001fvy.3,p.R602P	protein_coding, processed_transcript	uc010pjg.2	nonsynonymous SNV	exon11	c.G1091C	p.R364P	HSNETDRLPRCVRSTARLARALSPA	HSNETDRLPRCVPSTARLARALSPA	10.0	4.0	-	-	4335_1:160326901-160326901 G>C_HSNETDRLPRCVPSTARLARALSPA	0.0
3:48616679-48616679 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	COL7A1	ENST00000328333,p.R1780Q|ENST00000454817,p.R1780Q|NM_000094,p.R1780Q|uc003ctz.2,p.R1780Q	retained_intron, protein_coding, processed_transcript	uc003ctz.2	nonsynonymous SNV	exon61	c.G5339A	p.R1780Q	EKGDRGPPGLDGRSGLDGKPGAAGP	EKGDRGPPGLDGQSGLDGKPGAAGP	9.0	2.0	-	-	4258_3:48616679-48616679 C>T_EKGDRGPPGLDGQSGLDGKPGAAGP	0.0
17:67119536-67119536 C>T	0.0	4160	COLORECTAL	-	-	-	-	ABCA6	NM_080284,p.R427H|ENST00000284425,p.R427H|uc002jhw.1,p.R427H	retained_intron, protein_coding, processed_transcript	uc002jhw.1	nonsynonymous SNV	exon10	c.G1280A	p.R427H	LYFDKILPYGDERHYSPLFFLNSSS	LYFDKILPYGDEHHYSPLFFLNSSS	5.0	10.0	-	-	4160_17:67119536-67119536 C>T_LYFDKILPYGDEHHYSPLFFLNSSS	0.0
13:25021263-25021263 T>C	0.0	3795	MELANOMA	-	-	-	-	PARP4	uc001upl.3,p.Q1059R|NM_006437,p.Q1059R|ENST00000381989,p.Q1059R	retained_intron, protein_coding, processed_transcript	uc001upl.3	nonsynonymous SNV	exon26	c.A3176G	p.Q1059R	CSPSCHSVSVKWQQLNPDVPEALQA	CSPSCHSVSVKWRQLNPDVPEALQA	8.0	1.0	-	-	3795_13:25021263-25021263 T>C_CSPSCHSVSVKWRQLNPDVPEALQA	0.0
5:176675312-176675312 A>C	1.0	4317	COLORECTAL	-	-	-	1	NSD1	uc011dfx.2,p.E1191A|uc003mfr.4,p.E1543A|ENST00000347982,p.E1274A|ENST00000361032,p.E1440A|NM_022455,p.E1543A|uc003mfs.1,p.E1440A|uc003mft.4,p.E1274A|ENST00000354179,p.E1274A|ENST00000439151,p.E1543A|NM_172349,p.E1274A	retained_intron, protein_coding, nonsense_mediated_decay	uc011dfx.2	nonsynonymous SNV	exon12	c.A3572C	p.E1191A	MQGERGGGAALKENVCQNCEKLGEL	MQGERGGGAALKANVCQNCEKLGEL	9.0	3.0	-	-	4317_5:176675312-176675312 A>C_MQGERGGGAALKANVCQNCEKLGEL	0.0
3:123650034-123650034 C>T	1.0	4335	COLORECTAL	-	-	-	-	CCDC14	uc003egv.4,p.E254K|NM_022757,p.E572K|ENST00000419247,p.E254K|ENST00000310351,p.E453K|ENST00000489746,p.E413K|uc010hrt.3,p.E572K|ENST00000409697,p.E594K|ENST00000433542,p.E572K|uc003egy.4,p.E413K|ENST00000485727,p.E413K|uc003egx.4,p.E413K|uc003egz.2,p.E413K|ENST00000488653,p.E613K|uc011bjx.2,p.E613K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bjx.2	nonsynonymous SNV	exon12	c.G1837A	p.E613K	ALVNVKSSQFKLETAEKENQILGIT	ALVNVKSSQFKLKTAEKENQILGIT	8.0	9.0	-	-	4335_3:123650034-123650034 C>T_ALVNVKSSQFKLKTAEKENQILGIT	0.0
7:128489484-128489484 C>T	1.0	4266	COLORECTAL	-	-	-	-	FLNC	uc003voa.4,p.T1684M|uc003vnz.4,p.T1684M|NM_001127487,p.T1684M|ENST00000346177,p.T1684M|NM_001458,p.T1684M|ENST00000325888,p.T1684M	retained_intron, protein_coding	uc003voa.4	nonsynonymous SNV	exon30	c.C5051T	p.T1684M	AAGEGKVTCTVSTPDGAELDVDVVE	AAGEGKVTCTVSMPDGAELDVDVVE	7.0	10.0	-	-	4266_7:128489484-128489484 C>T_AAGEGKVTCTVSMPDGAELDVDVVE	0.0
4:87607882-87607882 G>T	0.0	4149	OVARIAN	-	-	-	1	PTPN13	uc003hpz.3,p.G105V|ENST00000427191,p.G105V|ENST00000502971,p.G105V|uc003hqa.3,p.G105V|NM_080684,p.G105V|NM_006264,p.G105V|ENST00000316707,p.G105V|ENST00000436978,p.G105V|ENST00000507902,p.G105V|NM_080685,p.G105V|ENST00000511467,p.G105V|uc003hqb.3,p.G105V|uc003hpy.3,p.G105V|NM_080683,p.G105V|ENST00000411767,p.G105V	retained_intron, protein_coding	uc003hqb.3	nonsynonymous SNV	exon4	c.G314T	p.G105V	LSDVEKIHIYSLGMTLYWGADYEVP	LSDVEKIHIYSLVMTLYWGADYEVP	5.0	7.0	-	-	4149_4:87607882-87607882 G>T_LSDVEKIHIYSLVMTLYWGADYEVP	0.0
16:13328967-13328967 C>A	0.0	4326	BREAST	-	-	-	-	SHISA9	uc010uyy.2,p.P326T|ENST00000558583,p.P367T|NM_001145204,p.P326T|ENST00000424107,p.P326T	protein_coding, processed_transcript	uc010uyy.2	nonsynonymous SNV	exon5	c.C976A	p.P326T	AELAAKGNLPLHPVRVEDEPRAFSP	AELAAKGNLPLHTVRVEDEPRAFSP	5.0	4.0	-	-	4326_16:13328967-13328967 C>A_AELAAKGNLPLHTVRVEDEPRAFSP	0.0
15:85400937-85400937 G>C	0.0	4258	ENDOMETRIAL	-	-	-	-	ALPK3	NM_020778,p.G1192R|uc002ble.3,p.G1192R|ENST00000258888,p.G1192R	retained_intron, protein_coding	uc002ble.3	nonsynonymous SNV	exon6	c.G3574C	p.G1192R	AGGESQVGAATGGLVPSATLTPTVE	AGGESQVGAATGRLVPSATLTPTVE	4.0	7.0	-	-	4258_15:85400937-85400937 G>C_AGGESQVGAATGRLVPSATLTPTVE	0.0
16:3063874-3063874 G>A	0.0	2591	MELANOMA	-	-	-	-	CLDN9	ENST00000445369,p.A171T|NM_020982,p.A171T|uc010uwo.1,p.A171T	protein_coding	uc010uwo.1	nonsynonymous SNV	exon1	c.G511A	p.A171T	ELGASLYLGWAAAALLMLGGGLLCC	ELGASLYLGWAATALLMLGGGLLCC	1.0	10.0	-	-	2591_16:3063874-3063874 G>A_ELGASLYLGWAATALLMLGGGLLCC	0.0
5:180276265-180276265 G>A	1.0	3903	MELANOMA	-	-	-	-	ZFP62	uc010jlk.3,p.L711F|NM_152283,p.L711F|uc021yjo.1,p.L711F|ENST00000502412,p.L744F|uc011dhe.2,p.L711F|ENST00000359141,p.L684F|uc011dhf.2,p.L744F|ENST00000512132,p.L711F|NM_001172638,p.L744F	retained_intron, protein_coding, processed_transcript	uc021yjo.1	nonsynonymous SNV	exon1	c.C2131T	p.L711F	VECGKSFSYSSLLSQHKRIHTGEKP	VECGKSFSYSSLFSQHKRIHTGEKP	7.0	1.0	-	-	3903_5:180276265-180276265 G>A_VECGKSFSYSSLFSQHKRIHTGEKP	0.0
10:75548934-75548934 A>G	0.0	4245	COLORECTAL	-	-	-	-	ZSWIM8	ENST00000433366,p.D148G|uc009xrl.3,p.D148G|uc001jvj.3,p.D148G|ENST00000604729,p.D148G|ENST00000603114,p.D148G|ENST00000398706,p.D148G|uc001jve.3,p.D148G|NM_001242488,p.D148G|NM_015037,p.D148G|NM_001242487,p.D148G|ENST00000605216,p.D148G|uc001jvf.3,p.D148G|ENST00000604524,p.D148G	protein_coding, processed_transcript, nonsense_mediated_decay	uc009xrl.3	nonsynonymous SNV	exon3	c.A443G	p.D148G	RGDQLFRMRAVKDPLQIGFHLSATV	RGDQLFRMRAVKGPLQIGFHLSATV	9.0	5.0	-	-	4245_10:75548934-75548934 A>G_RGDQLFRMRAVKGPLQIGFHLSATV	0.0
6:125397806-125397806 C>T	1.0	3466	MELANOMA	-	-	-	-	RNF217	uc003pzs.3,p.H137Y|ENST00000521654,p.H429Y|NM_001286398,p.H429Y|ENST00000560949,p.H194Y|ENST00000275184,p.H73Y|uc003pzr.3,p.H194Y|NM_152553,p.H137Y|ENST00000359704,p.H137Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003pzs.3	nonsynonymous SNV	exon6	c.C409T	p.H137Y	QRNAQKCPKCKIHIQRTEGCDHMTC	QRNAQKCPKCKIYIQRTEGCDHMTC	8.0	9.0	-	-	3466_6:125397806-125397806 C>T_QRNAQKCPKCKIYIQRTEGCDHMTC	0.0
1:1247685-1247685 G>T	1.0	4326	BREAST	-	-	-	-	CPSF3L	uc009vjz.2,p.R488S|uc010nyj.2,p.R481S|NM_001256463,p.R409S|ENST00000435064,p.R510S|NM_017871,p.R510S|NM_001256456,p.R516S|uc001aeg.2,p.R386S|NM_001256462,p.R412S|NM_001256460,p.R481S|ENST00000540437,p.R516S|ENST00000450926,p.R488S|ENST00000545578,p.R481S|uc001aeh.2,p.R409S|uc001aef.2,p.R516S|ENST00000419704,p.R409S|ENST00000411962,p.R412S|uc001aei.2,p.R412S|uc001aek.2,p.R252S|uc001aee.2,p.R510S|ENST00000421495,p.R252S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010nyj.2	nonsynonymous SNV	exon16	c.C1441A	p.R481S	ALKELGLAEHQLRFTCRVHLHDTRK	ALKELGLAEHQLSFTCRVHLHDTRK	9.0	1.0	-	-	4326_1:1247685-1247685 G>T_ALKELGLAEHQLSFTCRVHLHDTRK	0.0
17:18049351-18049351 G>A	0.0	3903	MELANOMA	-	-	-	-	MYO15A	ENST00000205890,p.G2147S|uc021trm.1,p.G2147S|NM_016239,p.G2147S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021trm.1	nonsynonymous SNV	exon29	c.G6439A	p.G2147S	VWHNHNAHNAERGWLLLAACLSGFA	VWHNHNAHNAERSWLLLAACLSGFA	2.0	5.0	-	-	3903_17:18049351-18049351 G>A_VWHNHNAHNAERSWLLLAACLSGFA	0.0
11:111853103-111853103 G>A	1.0	4326	BREAST	-	-	-	-	DIXDC1	ENST00000440460,p.G270E|ENST00000315253,p.G59E	retained_intron, protein_coding, processed_transcript	ENST00000440460	nonsynonymous SNV	exon7	c.G809A	p.G270E	GTDSPLSRDWRPGPGTYLETSWEEQ	GTDSPLSRDWRPEPGTYLETSWEEQ	8.0	7.0	-	-	4326_11:111853103-111853103 G>A_GTDSPLSRDWRPEPGTYLETSWEEQ	0.0
17:54535320-54535320 G>A	0.0	4245	COLORECTAL	-	-	-	-	ANKFN1	ENST00000318698,p.A516T|uc002iun.1,p.A516T|ENST00000566473,p.A516T|NM_153228,p.A516T	retained_intron, protein_coding, processed_transcript	uc002iun.1	nonsynonymous SNV	exon13	c.G1546A	p.A516T	SSTVLQTRQKMLAATAQLQNLLGTH	SSTVLQTRQKMLTATAQLQNLLGTH	4.0	10.0	-	-	4245_17:54535320-54535320 G>A_SSTVLQTRQKMLTATAQLQNLLGTH	0.0
7:144098565-144098565 C>T	0.0	3775	CERVICAL	-	-	-	-	NOBOX	ENST00000467773,p.E140K|uc022aoj.1,p.E140K|ENST00000223140,p.E55K|ENST00000483238,p.E140K|NM_001080413,p.E140K	protein_coding	uc022aoj.1	nonsynonymous SNV	exon4	c.G418A	p.E140K	SEELPPSCTISGEKKPPAVSGEATG	SEELPPSCTISGKKKPPAVSGEATG	1.0	7.0	-	-	3775_7:144098565-144098565 C>T_SEELPPSCTISGKKKPPAVSGEATG	0.0
X:129546340-129546340 A>C	0.0	4196	COLORECTAL	-	-	-	-	RBMX2	ENST00000305536,p.K163Q|uc004evt.3,p.K163Q|NM_016024,p.K163Q	protein_coding, processed_transcript	uc004evt.3	nonsynonymous SNV	exon6	c.A487C	p.K163Q	DEKPTKKHKKDKKEKKKKKKEKEKA	DEKPTKKHKKDKQEKKKKKKEKEKA	8.0	8.0	-	-	4196_X:129546340-129546340 A>C_DEKPTKKHKKDKQEKKKKKKEKEKA	0.0
19:49344429-49344429 G>A	0.0	4235	COLORECTAL	-	-	-	-	PLEKHA4	uc002pkx.3,p.R628C|ENST00000263265,p.R628C|NM_020904,p.R628C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002pkx.3	nonsynonymous SNV	exon17	c.C1882T	p.R628C	LLTLGRTLSPARRQPDVEQRPVVGH	LLTLGRTLSPARCQPDVEQRPVVGH	6.0	1.0	-	-	4235_19:49344429-49344429 G>A_LLTLGRTLSPARCQPDVEQRPVVGH	0.0
16:67315951-67315951 G>A	1.0	3775	CERVICAL	-	-	-	-	PLEKHG4	NM_015432,p.A349T|uc010ceg.3,p.A268T|uc002eso.4,p.A349T|NM_001129727,p.A349T|NM_001129728,p.A349T|uc010cef.3,p.A349T|uc002ess.4,p.A349T|ENST00000450733,p.A268T|uc002esq.4,p.A349T|ENST00000427155,p.A349T|ENST00000379344,p.A349T|NM_001129729,p.A349T|ENST00000360461,p.A349T|NM_001129731,p.A268T|uc002esp.4,p.A156T	retained_intron, protein_coding, nonsense_mediated_decay	uc010ceg.3	nonsynonymous SNV	exon6	c.G802A	p.A268T	LEALLQNCQAACALLQGAIESVKAV	LEALLQNCQAACTLLQGAIESVKAV	8.0	9.0	-	-	3775_16:67315951-67315951 G>A_LEALLQNCQAACTLLQGAIESVKAV	0.0
6:79752663-79752663 G>A	1.0	3784	MELANOMA	-	-	-	-	PHIP	uc011dyp.2,p.P166L|NM_017934,p.P166L|ENST00000275034,p.P166L|uc003pir.3,p.P166L	protein_coding, processed_transcript	uc011dyp.2	nonsynonymous SNV	exon7	c.C497T	p.P166L	KLNGKYRLERLVPTAVYQHMKMHKR	KLNGKYRLERLVLTAVYQHMKMHKR	7.0	9.0	-	-	3784_6:79752663-79752663 G>A_KLNGKYRLERLVLTAVYQHMKMHKR	0.0
5:169509808-169509808 C>A	0.0	4316	COLORECTAL	-	-	-	-	DOCK2	uc003maf.3,p.S1813R|uc003mah.3,p.S369R|NM_004946,p.S1813R|ENST00000540750,p.S874R|uc010jjm.3,p.S1305R|ENST00000256935,p.S1813R|ENST00000520908,p.S1305R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jjm.3	nonsynonymous SNV	exon38	c.C3915A	p.S1305R	KKVNQFFKTMLASKSAEEGKQIPDS	KKVNQFFKTMLARKSAEEGKQIPDS	6.0	6.0	-	-	4316_5:169509808-169509808 C>A_KKVNQFFKTMLARKSAEEGKQIPDS	0.0
18:48722969-48722969 G>C	1.0	4240	BREAST	-	-	-	-	MEX3C	ENST00000406189,p.S241C|uc002lfc.4,p.S241C|NM_016626,p.S241C	protein_coding, processed_transcript	uc002lfc.4	nonsynonymous SNV	exon1	c.C722G	p.S241C	SVNTTECVPVPSSEHVAEIVGRQGC	SVNTTECVPVPSCEHVAEIVGRQGC	7.0	9.0	-	-	4240_18:48722969-48722969 G>C_SVNTTECVPVPSCEHVAEIVGRQGC	0.0
6:31779566-31779566 C>A	0.0	4129	NSCLC	-	-	-	-	HSPA1L	ENST00000417199,p.A62S|NM_005527,p.A62S|uc021yuz.1,p.A62S|uc010jte.3,p.A62S|uc003nxh.3,p.A62S|ENST00000375654,p.A62S	protein_coding	uc021yuz.1	nonsynonymous SNV	exon1	c.G184T	p.A62S	ERLIGDAAKNQVAMNPQNTVFDAKR	ERLIGDAAKNQVSMNPQNTVFDAKR	5.0	7.0	-	-	4129_6:31779566-31779566 C>A_ERLIGDAAKNQVSMNPQNTVFDAKR	0.0
17:42452395-42452395 C>T	0.0	4235	COLORECTAL	-	-	-	-	ITGA2B	ENST00000353281,p.A938T	retained_intron, protein_coding	ENST00000353281	nonsynonymous SNV	exon27	c.G2812A	p.A938T	MARGQRAMVTVLAFLWLPSLYQVWT	MARGQRAMVTVLTFLWLPSLYQVWT	3.0	3.0	-	-	4235_17:42452395-42452395 C>T_MARGQRAMVTVLTFLWLPSLYQVWT	0.0
9:14857595-14857595 T>A	1.0	4317	COLORECTAL	-	-	-	-	FREM1	ENST00000422223,p.I262F|NM_144966,p.I262F|uc003zlm.3,p.I262F|ENST00000380880,p.I262F|ENST00000380881,p.I262F|ENST00000380875,p.I262F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zlm.3	nonsynonymous SNV	exon6	c.A784T	p.I262F	LDPPSPNIDYISIQLDLTDTRSKIV	LDPPSPNIDYISFQLDLTDTRSKIV	6.0	10.0	-	-	4317_9:14857595-14857595 T>A_LDPPSPNIDYISFQLDLTDTRSKIV	0.0
2:128072428-128072428 C>T	1.0	4246	COLORECTAL	-	-	-	-	MAP3K2	NM_006609,p.G453D|uc002toj.2,p.G453D|ENST00000344908,p.G453D|ENST00000409947,p.G453D	protein_coding	uc002toj.2	nonsynonymous SNV	exon14	c.G1358A	p.G453D	PGGSIKDQLKAYGALTENVTRKYTR	PGGSIKDQLKAYDALTENVTRKYTR	7.0	8.0	-	-	4246_2:128072428-128072428 C>T_PGGSIKDQLKAYDALTENVTRKYTR	0.0
8:121500491-121500491 T>C	0.0	4335	COLORECTAL	-	-	-	-	MTBP	ENST00000305949,p.S420P|uc003ypc.2,p.S420P|NM_022045,p.S420P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ypc.2	nonsynonymous SNV	exon12	c.T1258C	p.S420P	NGNRRCKATLIHSANQINGSFALNL	NGNRRCKATLIHPANQINGSFALNL	5.0	4.0	-	-	4335_8:121500491-121500491 T>C_NGNRRCKATLIHPANQINGSFALNL	0.0
1:23418880-23418880 T>G	0.0	4335	COLORECTAL	-	-	-	-	LUZP1	ENST00000418342,p.E625D|uc001bgm.1,p.E625D|ENST00000302291,p.E625D|ENST00000374623,p.E625D|uc010odv.1,p.E625D|NM_001142546,p.E625D|uc001bgk.2,p.E625D|ENST00000314174,p.E625D|NM_033631,p.E625D|uc001bgl.3,p.E625D	protein_coding	uc010odv.1	nonsynonymous SNV	exon3	c.A1875C	p.E625D	ENILQGFSTSHKEGVNQPAAVVMED	ENILQGFSTSHKDGVNQPAAVVMED	6.0	6.0	-	-	4335_1:23418880-23418880 T>G_ENILQGFSTSHKDGVNQPAAVVMED	0.0
17:40849754-40849754 G>A	1.0	4244	COLORECTAL	-	-	-	-	CNTNAP1	uc002iay.3,p.G1251R|NM_003632,p.G1251R|ENST00000264638,p.G1251R	retained_intron, protein_coding, nonsense_mediated_decay	uc002iay.3	nonsynonymous SNV	exon22	c.G3751A	p.G1251R	LRVQGELSESNCGAMPRLVSEVPPE	LRVQGELSESNCRAMPRLVSEVPPE	6.0	10.0	-	-	4244_17:40849754-40849754 G>A_LRVQGELSESNCRAMPRLVSEVPPE	0.0
6:35928870-35928870 A>G	0.0	4281	COLORECTAL	-	-	-	-	SLC26A8	uc003oll.3,p.W385R|uc003olm.3,p.W490R|NM_138718,p.W385R|NM_052961,p.W490R|uc003olk.3,p.W72R|ENST00000394602,p.W385R|ENST00000490799,p.W490R|NM_001193476,p.W490R|uc003oln.3,p.W490R|ENST00000355574,p.W490R	retained_intron, protein_coding, nonsense_mediated_decay	uc003oln.3	nonsynonymous SNV	exon13	c.T1468C	p.W490R	SLWRQDQYDCALWMMTFSSSIFLGL	SLWRQDQYDCALRMMTFSSSIFLGL	2.0	6.0	-	-	4281_6:35928870-35928870 A>G_SLWRQDQYDCALRMMTFSSSIFLGL	0.0
2:166246105-166246105 G>A	0.0	3903	MELANOMA	-	-	-	-	SCN2A	ENST00000283256,p.S1930N|ENST00000375427,p.S1930N|NM_001040143,p.S1930N|uc002udc.3,p.S1930N|NM_021007,p.S1930N|ENST00000375437,p.S1930N|ENST00000357398,p.S1930N|uc002udd.3,p.S1930N|uc002ude.3,p.S1930N|uc021vry.1,p.S430N|NM_001040142,p.S1930N	retained_intron, protein_coding	uc021vry.1	nonsynonymous SNV	exon3	c.G1289A	p.S430N	RYLLKQKVKKVSSIYKKDKGKECDG	RYLLKQKVKKVSNIYKKDKGKECDG	4.0	9.0	-	-	3903_2:166246105-166246105 G>A_RYLLKQKVKKVSNIYKKDKGKECDG	0.0
5:38884169-38884169 G>A	1.0	3713	MELANOMA	-	-	-	-	OSMR	NM_003999,p.G220E|ENST00000274276,p.G220E|ENST00000502536,p.G220E|uc003jlm.2,p.G220E|NM_001168355,p.G220E|uc003jln.2,p.G220E	protein_coding, nonsense_mediated_decay	uc003jln.2	nonsynonymous SNV	exon5	c.G659A	p.G220E	NKGTNIYCEASQGNVSEGMKGIVLF	NKGTNIYCEASQENVSEGMKGIVLF	6.0	3.0	-	-	3713_5:38884169-38884169 G>A_NKGTNIYCEASQENVSEGMKGIVLF	0.0
5:140725338-140725338 C>T	0.0	4301	MELANOMA	-	-	ID=COSM267132;OCCURENCE=1(large_intestine)	-	PCDHGA3	uc003ljm.2,p.R580C|NM_018916,p.R580C|NM_032011,p.R580C|uc011dap.2,p.R580C|ENST00000253812,p.R580C	protein_coding	uc011dap.2	nonsynonymous SNV	exon1	c.C1738T	p.R580C	PTDGSTGVELAPRSAEPGYLVTKVV	PTDGSTGVELAPCSAEPGYLVTKVV	4.0	5.0	-	-	4301_5:140725338-140725338 C>T_PTDGSTGVELAPCSAEPGYLVTKVV	0.0
14:38724883-38724883 C>A	0.0	4316	COLORECTAL	-	-	-	-	CLEC14A	ENST00000342213,p.W115C|NM_175060,p.W115C|uc001wum.2,p.W115C	protein_coding	uc001wum.2	nonsynonymous SNV	exon1	c.G345T	p.W115C	CTLENEPLRGFSWLSSDPGGLESDT	CTLENEPLRGFSCLSSDPGGLESDT	3.0	5.0	-	-	4316_14:38724883-38724883 C>A_CTLENEPLRGFSCLSSDPGGLESDT	0.0
9:120474944-120474944 T>G	1.0	4245	COLORECTAL	-	-	-	-	TLR4	ENST00000355622,p.L180V|uc004bka.4,p.L140V|uc004bjz.4,p.L180V|ENST00000394487,p.L140V|NM_003266,p.L140V|NM_138554,p.L180V	protein_coding, processed_transcript	uc004bka.4	nonsynonymous SNV	exon4	c.T418G	p.L140V	PEYFSNLTNLEHLDLSSNKIQSIYC	PEYFSNLTNLEHVDLSSNKIQSIYC	8.0	1.0	-	-	4245_9:120474944-120474944 T>G_PEYFSNLTNLEHVDLSSNKIQSIYC	0.0
1:45125929-45125929 G>A	1.0	4136	BREAST	-	-	-	-	TMEM53	NM_001300747,p.R34W|uc001cmc.3,p.R34W|NM_024587,p.R34W|ENST00000372242,p.R34W|ENST00000420706,p.R34W|NM_001300748,p.R34W|ENST00000372237,p.R34W|ENST00000372235,p.R34W|ENST00000372243,p.R34W	protein_coding, processed_transcript	uc001cmc.3	nonsynonymous SNV	exon2	c.C100T	p.R34W	NSPSPGGKEAETRQPVVILLGWGGC	NSPSPGGKEAETWQPVVILLGWGGC	7.0	8.0	-	-	4136_1:45125929-45125929 G>A_NSPSPGGKEAETWQPVVILLGWGGC	0.0
9:114412127-114412127 C>T	0.0	4235	COLORECTAL	-	-	-	-	DNAJC25	ENST00000313525,p.S295F|NM_001015882,p.S295F|uc004bfm.3,p.S173F|uc004bfl.3,p.S295F	protein_coding, nonsense_mediated_decay	uc004bfm.3	nonsynonymous SNV	exon4	c.C518T	p.S173F	LYIIRKSMKMSKSQFDSLEDHQKET	LYIIRKSMKMSKFQFDSLEDHQKET	5.0	4.0	-	-	4235_9:114412127-114412127 C>T_LYIIRKSMKMSKFQFDSLEDHQKET	0.0
15:76633485-76633485 G>A	0.0	4158	COLORECTAL	-	-	-	-	ISL2	NM_145805,p.G269E|ENST00000290759,p.G269E|uc002bbw.1,p.G269E	protein_coding, nonsense_mediated_decay	uc002bbw.1	nonsynonymous SNV	exon5	c.G806A	p.G269E	QQQQHSDKTSLQGLTGTPLVAGSPI	QQQQHSDKTSLQELTGTPLVAGSPI	3.0	6.0	-	-	4158_15:76633485-76633485 G>A_QQQQHSDKTSLQELTGTPLVAGSPI	0.0
5:13868101-13868101 C>T	0.0	3903	MELANOMA	-	-	-	-	DNAH5	ENST00000265104,p.E1279K|uc003jfd.2,p.E1279K|NM_001369,p.E1279K	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon25	c.G3835A	p.E1279K	QISIDFQVGPIEESYALLNRYGLLI	QISIDFQVGPIEKSYALLNRYGLLI	1.0	2.0	-	-	3903_5:13868101-13868101 C>T_QISIDFQVGPIEKSYALLNRYGLLI	0.0
9:97063082-97063082 G>T	0.0	4346	COLORECTAL	-	-	-	-	ZNF169	uc004aum.1,p.K414N|uc022bki.1,p.K415N|NM_001301275,p.K223N|ENST00000395395,p.K414N|NM_003448,p.K415N|NM_194320,p.K414N	protein_coding, processed_transcript	uc022bki.1	nonsynonymous SNV	exon4	c.G1245T	p.K415N	YVCAECGHSFRQKVTLIRHQRTHTG	YVCAECGHSFRQNVTLIRHQRTHTG	6.0	2.0	-	-	4346_9:97063082-97063082 G>T_YVCAECGHSFRQNVTLIRHQRTHTG	0.0
5:31508876-31508876 G>A	1.0	3466	MELANOMA	-	-	-	1	DROSHA	NM_001100412,p.S443F|ENST00000344624,p.S480F|ENST00000513349,p.S443F|uc003jhg.2,p.S480F|uc003jhi.2,p.S443F|NM_013235,p.S480F|ENST00000442743,p.S443F|uc003jhh.2,p.S443F|ENST00000511367,p.S480F|uc010iui.1,p.S403F	retained_intron, protein_coding, processed_transcript	uc010iui.1	nonsynonymous SNV	exon4	c.C1208T	p.S403F	PPKTKLDEDLESSSESECESDEDST	PPKTKLDEDLESFSESECESDEDST	10.0	1.0	-	-	3466_5:31508876-31508876 G>A_PPKTKLDEDLESFSESECESDEDST	0.0
20:33570300-33570300 G>A	1.0	4189	MELANOMA	-	-	-	-	MYH7B	uc002xbi.2,p.R231Q|NM_020884,p.R231Q|ENST00000262873,p.R231Q	retained_intron, protein_coding, processed_transcript	uc002xbi.2	nonsynonymous SNV	exon10	c.G692A	p.R231Q	GESGAGKTVNTKRVIQYFAIVAALG	GESGAGKTVNTKQVIQYFAIVAALG	2.0	2.0	-	-	4189_20:33570300-33570300 G>A_GESGAGKTVNTKQVIQYFAIVAALG	0.0
1:2530093-2530093 C>T	0.0	3903	MELANOMA	-	-	-	-	MMEL1	uc001ajy.2,p.R393K|ENST00000288709,p.R384K|ENST00000502556,p.R236K|NM_033467,p.R393K|ENST00000504800,p.R393K|ENST00000378412,p.R393K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ajy.2	nonsynonymous SNV	exon12	c.G1178A	p.R393K	QNLENIIDTYSARTIQNYLVWRLVL	QNLENIIDTYSAKTIQNYLVWRLVL	9.0	7.0	-	-	3903_1:2530093-2530093 C>T_QNLENIIDTYSAKTIQNYLVWRLVL	0.0
7:20685688-20685688 G>A	0.0	4301	MELANOMA	-	-	-	-	ABCB5	uc010kuh.3,p.G303E|NM_001163941,p.G303E|ENST00000404938,p.G303E	protein_coding, processed_transcript, nonsense_mediated_decay	uc010kuh.3	nonsynonymous SNV	exon9	c.G908A	p.G303E	LGAVYFFMNGTYGLAFWYGTSLILN	LGAVYFFMNGTYELAFWYGTSLILN	3.0	10.0	-	-	4301_7:20685688-20685688 G>A_LGAVYFFMNGTYELAFWYGTSLILN	0.0
3:133375559-133375559 G>A	1.0	3713	MELANOMA	-	-	-	-	TOPBP1	NM_007027,p.P169L|uc003eps.3,p.P169L|ENST00000260810,p.P169L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003eps.3	nonsynonymous SNV	exon5	c.C506T	p.P169L	LVAANLKKPILLPSWIKTLWEKSQE	LVAANLKKPILLLSWIKTLWEKSQE	8.0	3.0	-	-	3713_3:133375559-133375559 G>A_LVAANLKKPILLLSWIKTLWEKSQE	0.0
16:67325726-67325726 C>G	0.0	4240	BREAST	-	-	-	-	KCTD19	uc002esu.2,p.E745Q|NM_001100915,p.E745Q|ENST00000304372,p.E745Q|uc010vjj.1,p.E488Q|uc002est.2,p.E517Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vjj.1	nonsynonymous SNV	exon12	c.G1462C	p.E488Q	KQRTKERESPAPEQPLPEASEVDSL	KQRTKERESPAPQQPLPEASEVDSL	1.0	10.0	-	-	4240_16:67325726-67325726 C>G_KQRTKERESPAPQQPLPEASEVDSL	0.0
19:50753914-50753914 C>T	1.0	2556	MELANOMA	-	-	-	-	MYH14	NM_001077186,p.A600V|ENST00000599920,p.A600V|ENST00000598205,p.A600V|ENST00000596571,p.A592V|ENST00000425460,p.A600V|ENST00000376970,p.A592V|uc002prq.1,p.A600V|ENST00000440075,p.A600V|uc002prr.1,p.A592V|ENST00000262269,p.A600V|NM_024729,p.A592V|uc010enu.1,p.A600V|ENST00000601313,p.A600V|NM_001145809,p.A600V	retained_intron, protein_coding	uc010enu.1	nonsynonymous SNV	exon15	c.C1799T	p.A600V	PKFQRPRHLRDQADFSVLHYAGKVD	PKFQRPRHLRDQVDFSVLHYAGKVD	7.0	7.0	CD8	-	2556_19:50753914-50753914 C>T_PKFQRPRHLRDQVDFSVLHYAGKVD	1.0
13:49076955-49076955 G>A	1.0	4278	COLORECTAL	-	-	-	-	RCBTB2	ENST00000344532,p.S341F|uc001vcj.3,p.S293F|NM_001286830,p.S346F|uc010tgg.2,p.S346F|uc001vci.3,p.S317F|NM_001286832,p.S67F|ENST00000544492,p.S67F|NM_001268,p.S341F|ENST00000430805,p.S346F|uc001vch.3,p.S341F|NM_001286831,p.S317F|uc010tgh.2,p.S67F	protein_coding, processed_transcript	uc010tgh.2	nonsynonymous SNV	exon6	c.C200T	p.S67F	GHVYMWGQCRGQSVILPHLTHFSCT	GHVYMWGQCRGQFVILPHLTHFSCT	6.0	7.0	-	-	4278_13:49076955-49076955 G>A_GHVYMWGQCRGQFVILPHLTHFSCT	0.0
14:63174599-63174599 T>A	0.0	4046	OVARIAN	-	-	-	-	KCNH5	NM_139318,p.D865V|ENST00000322893,p.D865V|uc001xfx.3,p.D865V	protein_coding	uc001xfx.3	nonsynonymous SNV	exon11	c.A2594T	p.D865V	VTKNPLRKTDSCDSGITKSDLRLDK	VTKNPLRKTDSCVSGITKSDLRLDK	1.0	5.0	-	-	4046_14:63174599-63174599 T>A_VTKNPLRKTDSCVSGITKSDLRLDK	0.0
5:149323926-149323926 C>T	0.0	3795	MELANOMA	-	-	-	-	PDE6A	uc021yfs.1,p.G104D|uc003lrg.4,p.G104D|NM_000440,p.G104D|ENST00000255266,p.G104D	retained_intron, protein_coding	uc021yfs.1	nonsynonymous SNV	exon1	c.G311A	p.G104D	DRMSLFMYRTRNGIAELATRLFNVH	DRMSLFMYRTRNDIAELATRLFNVH	1.0	10.0	-	-	3795_5:149323926-149323926 C>T_DRMSLFMYRTRNDIAELATRLFNVH	0.0
10:54041914-54041914 T>C	1.0	3879	MELANOMA	-	-	-	-	PRKG1	uc001jjo.3,p.V516A|ENST00000373980,p.V516A|NM_001098512,p.V501A|uc001jjm.3,p.V501A|ENST00000401604,p.V501A|ENST00000373985,p.V489A|NM_006258,p.V516A|ENST00000373975,p.V219A|uc009xow.2,p.V219A	protein_coding	uc009xow.2	nonsynonymous SNV	exon11	c.T656C	p.V219A	NLILDHRGYAKLVDFGFAKKIGFGK	NLILDHRGYAKLADFGFAKKIGFGK	8.0	4.0	-	-	3879_10:54041914-54041914 T>C_NLILDHRGYAKLADFGFAKKIGFGK	0.0
19:50945515-50945515 C>T	0.0	4287	COLORECTAL	-	-	-	-	MYBPC2	NM_004533,p.P283S|ENST00000357701,p.P283S|uc002psf.2,p.P283S	retained_intron, protein_coding	uc002psf.2	nonsynonymous SNV	exon9	c.C847T	p.P283S	GNKIKLMVEISDPDLTLKWFKNGQE	GNKIKLMVEISDSDLTLKWFKNGQE	3.0	10.0	-	-	4287_19:50945515-50945515 C>T_GNKIKLMVEISDSDLTLKWFKNGQE	0.0
7:129987659-129987659 G>A	0.0	4238	COLORECTAL	-	-	-	-	CPA5	ENST00000466363,p.G57R|ENST00000463587,p.G57R|uc003vpu.1,p.G57R|NM_001127442,p.G57R|NM_080385,p.G57R|uc010lme.1,p.G57R|ENST00000474905,p.G57R|uc003vps.2,p.G57R|uc003vpt.2,p.G57R|NM_001127441,p.G57R|uc010lmd.1,p.G57R|ENST00000393213,p.G57R|ENST00000355388,p.G57R|ENST00000485477,p.G57R|ENST00000461828,p.G57R|ENST00000431780,p.G57R	retained_intron, protein_coding	uc010lme.1	nonsynonymous SNV	exon3	c.G169A	p.G57R	VLAKDEKQLSLLGDLEGLKPQKVDF	VLAKDEKQLSLLRDLEGLKPQKVDF	3.0	8.0	-	-	4238_7:129987659-129987659 G>A_VLAKDEKQLSLLRDLEGLKPQKVDF	0.0
14:91937309-91937309 A>C	1.0	4345	COLORECTAL	-	-	-	-	SMEK1	uc001xzn.3,p.L511R|ENST00000428424,p.L272R|uc010atz.3,p.L272R|NM_001284281,p.L272R|uc001xzo.3,p.L498R|ENST00000554943,p.L511R|ENST00000554390,p.L498R|NM_001284280,p.L498R|ENST00000554684,p.L498R|uc001xzm.3,p.L498R|ENST00000555462,p.L272R|ENST00000337238,p.L498R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay, non_stop_decay	uc010atz.3	nonsynonymous SNV	exon8	c.T815G	p.L272R	SKDDFQTAQLLALVLELLTFCVEHH	SKDDFQTAQLLARVLELLTFCVEHH	10.0	1.0	-	-	4345_14:91937309-91937309 A>C_SKDDFQTAQLLARVLELLTFCVEHH	0.0
20:47632838-47632838 A>C	0.0	4126	NSCLC	-	-	-	-	ARFGEF2	NM_006420,p.T1401P|uc002xtx.4,p.T1401P|ENST00000371917,p.T1401P|uc010zyf.2,p.T694P	protein_coding, processed_transcript	uc010zyf.2	nonsynonymous SNV	exon17	c.A2080C	p.T694P	EQLSEKSEWMTTTCNHALYAICDVF	EQLSEKSEWMTTPCNHALYAICDVF	5.0	1.0	-	-	4126_20:47632838-47632838 A>C_EQLSEKSEWMTTPCNHALYAICDVF	0.0
12:6729913-6729913 G>A	1.0	4196	COLORECTAL	-	-	-	-	LPAR5	ENST00000431922,p.R168W|NM_020400,p.R168W|ENST00000329858,p.R168W|uc010sff.1,p.R168W|NM_001142961,p.R168W|uc001qps.2,p.R168W|uc021qub.1,p.R168W|uc009zer.2,p.R168W	protein_coding, processed_transcript	uc021qub.1	nonsynonymous SNV	exon1	c.C502T	p.R168W	AARVHRPSRCRYRDLEVRLCFESFS	AARVHRPSRCRYWDLEVRLCFESFS	6.0	8.0	-	-	4196_12:6729913-6729913 G>A_AARVHRPSRCRYWDLEVRLCFESFS	0.0
7:45142964-45142964 G>A	1.0	2359	MELANOMA	-	-	-	-	TBRG4	uc011kcd.3,p.H393Y|NM_001261834,p.H393Y|uc003tmu.3,p.H207Y|ENST00000494076,p.H382Y|ENST00000395655,p.H272Y|uc003tmw.4,p.H272Y|NM_030900,p.H272Y|NM_199122,p.H272Y|uc003tmx.4,p.H272Y|uc003tmv.4,p.H382Y|ENST00000258770,p.H382Y|ENST00000361278,p.H272Y|NM_004749,p.H382Y	retained_intron, protein_coding, processed_transcript	uc011kcd.3	nonsynonymous SNV	exon6	c.C1177T	p.H393Y	CSVLLAFARLNFHPDQEDQFFSLVH	CSVLLAFARLNFYPDQEDQFFSLVH	10.0	4.0	-	-	2359_7:45142964-45142964 G>A_CSVLLAFARLNFYPDQEDQFFSLVH	0.0
5:118485291-118485291 G>T	1.0	3919	MELANOMA	-	-	-	-	DMXL1	ENST00000311085,p.G1257W|uc010jcl.1,p.G1257W|NM_001290322,p.G1084W|uc021ycw.1,p.G1084W|uc003ksd.2,p.G1257W|NM_001290321,p.G1257W|NM_005509,p.G1257W|ENST00000539542,p.G1257W	retained_intron, protein_coding, processed_transcript	uc021ycw.1	nonsynonymous SNV	exon18	c.G3250T	p.G1084W	SKQEPVITDSYSGSTPSITSLIKQS	SKQEPVITDSYSWSTPSITSLIKQS	7.0	9.0	-	-	3919_5:118485291-118485291 G>T_SKQEPVITDSYSWSTPSITSLIKQS	0.0
17:21319129-21319129 G>A	0.0	4246	COLORECTAL	-	-	-	-	KCNJ12,KCNJ18	uc021tss.1,p.V159I|NM_001194958,p.V159I	protein_coding	uc021tss.1	nonsynonymous SNV	exon3	c.G475A	p.V159I	GLRCVTEECLVAVFMVVAQSIVGCI	GLRCVTEECLVAIFMVVAQSIVGCI	2.0	4.0	-	-	4246_17:21319129-21319129 G>A_GLRCVTEECLVAIFMVVAQSIVGCI	0.0
9:4661904-4661904 C>G	0.0	3775	CERVICAL	-	-	-	-	SPATA6L	NM_001039395,p.E58Q|ENST00000475086,p.E58Q|uc011llz.2,p.E58Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011llz.2	nonsynonymous SNV	exon3	c.G172C	p.E58Q	AFPIMIQESMRFEKGIAPKIEFSTR	AFPIMIQESMRFQKGIAPKIEFSTR	4.0	10.0	-	-	3775_9:4661904-4661904 C>G_AFPIMIQESMRFQKGIAPKIEFSTR	0.0
16:71682831-71682831 G>A	1.0	3713	MELANOMA	-	-	-	-	PHLPP2	ENST00000568954,p.R1312W|NM_001289003,p.R1245W|ENST00000356272,p.R1312W|uc010cgf.3,p.R1245W|NM_015020,p.R1312W|ENST00000393524,p.R1245W|ENST00000567016,p.R1347W|uc002fax.3,p.R1312W	retained_intron, protein_coding, nonsense_mediated_decay	uc010cgf.3	nonsynonymous SNV	exon18	c.C3733T	p.R1245W	DSRLEPEPHEEDRTEPPEEFDTAL	DSRLEPEPHEEDWTEPPEEFDTAL	4.0	6.0	-	-	3713_16:71682831-71682831 G>A_DSRLEPEPHEEDWTEPPEEFDTAL	0.0
14:79933698-79933698 C>A	0.0	4245	COLORECTAL	-	-	-	-	NRXN3	uc001xur.5,p.R128S|ENST00000428277,p.R128S|uc010asw.4,p.R128S|uc001xuq.3,p.R128S|NM_138970,p.R128S|uc001xun.4,p.R760S|ENST00000554719,p.R760S|ENST00000335750,p.R760S|NM_001105250,p.R128S|NM_001272020,p.R128S|ENST00000557594,p.R128S|NM_004796,p.R760S|ENST00000281127,p.R128S|ENST00000554738,p.R1122S|ENST00000555387,p.R128S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010asw.4	nonsynonymous SNV	exon2	c.C382A	p.R128S	GFSTTVKDGILVRIDSAPGLGDFLQ	GFSTTVKDGILVSIDSAPGLGDFLQ	5.0	5.0	-	-	4245_14:79933698-79933698 C>A_GFSTTVKDGILVSIDSAPGLGDFLQ	0.0
2:86274322-86274322 G>A	0.0	4335	COLORECTAL	-	-	-	-	POLR1A	uc002sqs.3,p.S900L|NM_015425,p.S900L|ENST00000409681,p.S900L|ENST00000263857,p.S900L|uc010ytb.2,p.S266L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ytb.2	nonsynonymous SNV	exon6	c.C797T	p.S266L	QFPENSLQMMVQSGAKGSTVNTMQI	QFPENSLQMMVQLGAKGSTVNTMQI	7.0	7.0	-	-	4335_2:86274322-86274322 G>A_QFPENSLQMMVQLGAKGSTVNTMQI	0.0
12:58000277-58000277 C>T	0.0	4158	COLORECTAL	-	-	-	-	DTX3	NM_001286245,p.P2L|ENST00000549583,p.P2L|ENST00000551632,p.P2L	protein_coding	NM_001286245	nonsynonymous SNV	exon3	c.C5T	p.P2L	MPILSSSGSKMAAC	MLILSSSGSKMAAC	6.0	3.0	-	-	4158_12:58000277-58000277 C>T_MLILSSSGSKMAAC	0.0
2:97868124-97868124 A>T	1.0	4252	COLORECTAL	-	-	-	-	ANKRD36	ENST00000420699,p.R985W|NM_001164315,p.R985W|ENST00000461153,p.R985W|uc010yva.2,p.R985W	retained_intron, protein_coding	uc010yva.2	nonsynonymous SNV	exon48	c.A2953T	p.R985W	GIARENKDGEKSRTVSSEKPPGLKA	GIARENKDGEKSWTVSSEKPPGLKA	7.0	6.0	-	-	4252_2:97868124-97868124 A>T_GIARENKDGEKSWTVSSEKPPGLKA	0.0
9:2056748-2056748 G>A	1.0	4037	NSCLC	-	-	ID=COSM1169163,COSM1169164;OCCURENCE=1(pancreas)	-	SMARCA2	NM_001289397,p.R417Q|NM_139045,p.R417Q|ENST00000382203,p.R417Q|ENST00000357248,p.R417Q|uc003zhc.3,p.R417Q|uc003zhd.3,p.R417Q|NM_001289396,p.R417Q|ENST00000382194,p.R417Q|NM_003070,p.R417Q|ENST00000450198,p.R417Q|ENST00000349721,p.R417Q|uc010mha.3,p.R408Q	protein_coding, processed_transcript	uc010mha.3	nonsynonymous SNV	exon7	c.G1223A	p.R408Q	TLETALNSKAYKRSKRQTLREARMT	TLETALNSKAYKQSKRQTLREARMT	10.0	9.0	-	-	4037_9:2056748-2056748 G>A_TLETALNSKAYKQSKRQTLREARMT	0.0
8:99170029-99170029 C>T	1.0	3716	MELANOMA	-	-	-	-	POP1	ENST00000349693,p.P869S|uc003yij.4,p.P869S|uc003yik.3,p.P869S|NM_001145860,p.P869S|NM_015029,p.P869S|NM_001145861,p.P869S|ENST00000401707,p.P869S|uc011lgv.2,p.P869S	retained_intron, protein_coding	uc011lgv.2	nonsynonymous SNV	exon16	c.C2605T	p.P869S	VWVSLSLLSKGSPEPHTMICVPAKE	VWVSLSLLSKGSSEPHTMICVPAKE	5.0	5.0	-	-	3716_8:99170029-99170029 C>T_VWVSLSLLSKGSSEPHTMICVPAKE	0.0
1:249148217-249148217 A>C	1.0	4077	BILE DUCT	-	-	-	-	ZNF692	uc001iff.2,p.S313A|ENST00000366471,p.S313A|uc010pzr.2,p.S363A|uc001ifc.2,p.S358A|NM_001193328,p.S313A|ENST00000306601,p.S358A|ENST00000427146,p.S313A|uc001iez.2,p.S80A|uc031pta.1,p.S80A|NM_017865,p.S358A|ENST00000366469,p.S357A|ENST00000451251,p.S363A|NM_001136036,p.S363A|uc001ifb.2,p.S154A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pta.1	nonsynonymous SNV	exon6	c.T238G	p.S80A	NHHKKYQHIHQKSFSCPEPACGKSF	NHHKKYQHIHQKAFSCPEPACGKSF	8.0	10.0	-	-	4077_1:249148217-249148217 A>C_NHHKKYQHIHQKAFSCPEPACGKSF	0.0
7:102108561-102108561 C>T	1.0	3713	MELANOMA	-	-	-	-	LRWD1	uc003uzn.3,p.P244L|NM_152892,p.P244L|ENST00000292616,p.P244L	retained_intron, protein_coding, nonsense_mediated_decay	uc003uzn.3	nonsynonymous SNV	exon6	c.C731T	p.P244L	LKRPDDVPLSLSPSKRACASPSAQV	LKRPDDVPLSLSLSKRACASPSAQV	4.0	7.0	-	-	3713_7:102108561-102108561 C>T_LKRPDDVPLSLSLSKRACASPSAQV	0.0
6:166721479-166721479 G>A	0.0	4252	COLORECTAL	-	-	-	-	PRR18	uc003quw.1,p.A51V|ENST00000322583,p.A51V|ENST00000529616,p.A51V|NM_175922,p.A51V	protein_coding	uc003quw.1	nonsynonymous SNV	exon1	c.C152T	p.A51V	RPEGLLSSSWPSATLKRPPARRGPG	RPEGLLSSSWPSVTLKRPPARRGPG	3.0	7.0	-	-	4252_6:166721479-166721479 G>A_RPEGLLSSSWPSVTLKRPPARRGPG	0.0
5:140057599-140057599 T>A	1.0	4259	COLORECTAL	-	-	-	-	HARS	ENST00000307633,p.D115V|uc003lgw.4,p.D155V|ENST00000457527,p.D155V|uc011czn.3,p.D115V|NM_001258041,p.D155V|NM_001258042,p.D115V	retained_intron, protein_coding, nonsense_mediated_decay	uc011czn.3	nonsynonymous SNV	exon5	c.A344T	p.D115V	KLTNIKRYHIAKDFDIAGNFDPMIP	KLTNIKRYHIAKVFDIAGNFDPMIP	10.0	6.0	-	-	4259_5:140057599-140057599 T>A_KLTNIKRYHIAKVFDIAGNFDPMIP	0.0
2:173352859-173352859 C>G	1.0	4126	NSCLC	-	-	-	-	ITGA6	uc002uhp.1,p.A803G|ENST00000416789,p.A28G|ENST00000343713,p.A798G|NM_000210,p.A803G|ENST00000409080,p.A803G|uc010zdy.1,p.A684G|ENST00000264106,p.A842G|NM_001079818,p.A803G|ENST00000458358,p.A798G|uc010fqm.1,p.A449G|ENST00000409532,p.A684G|uc002uho.1,p.A803G|ENST00000375221,p.A842G|ENST00000442250,p.A842G|ENST00000264107,p.A803G	retained_intron, protein_coding	uc010zdy.1	nonsynonymous SNV	exon19	c.C2051G	p.A684G	VVIELLLSVSGVAKPSQVYFGGTVV	VVIELLLSVSGVGKPSQVYFGGTVV	7.0	6.0	-	-	4126_2:173352859-173352859 C>G_VVIELLLSVSGVGKPSQVYFGGTVV	0.0
8:113275993-113275993 C>T	0.0	3795	MELANOMA	-	-	-	2	CSMD3	uc003yns.3,p.G2448E|ENST00000352409,p.G3176E|uc003ynt.3,p.G3206E|ENST00000343508,p.G3206E|ENST00000297405,p.G3246E|uc003ynu.3,p.G3246E|ENST00000455883,p.G3077E|ENST00000339701,p.G2516E|NM_052900,p.G3077E|NM_198124,p.G3206E|uc011lhx.2,p.G3077E|NM_198123,p.G3246E	retained_intron, protein_coding, processed_transcript	uc011lhx.2	nonsynonymous SNV	exon59	c.G9230A	p.G3077E	PTPPQISNGRLEGTNFDWGFSISYI	PTPPQISNGRLEETNFDWGFSISYI	2.0	4.0	-	-	3795_8:113275993-113275993 C>T_PTPPQISNGRLEETNFDWGFSISYI	0.0
7:94855338-94855338 G>A	1.0	4213	COLORECTAL	-	-	ID=COSM1698935,COSM1698934;OCCURENCE=1(skin)	-	PPP1R9A	ENST00000289495,p.M652I|uc011kif.2,p.M652I|NM_017650,p.M652I|ENST00000433881,p.M652I|uc003unq.3,p.M652I|NM_001166160,p.M674I|ENST00000456331,p.M652I|NM_001166162,p.M652I|uc010lfj.3,p.M674I|NM_001166163,p.M652I|ENST00000340694,p.M652I|NM_001166161,p.M652I|uc003unp.3,p.M652I|uc011kig.2,p.M652I|ENST00000424654,p.M652I|ENST00000433360,p.M674I	protein_coding	uc011kig.2	nonsynonymous SNV	exon6	c.G1956A	p.M652I	EDEVGPVLPGSDMAIEVFELPENED	EDEVGPVLPGSDIAIEVFELPENED	7.0	9.0	-	-	4213_7:94855338-94855338 G>A_EDEVGPVLPGSDIAIEVFELPENED	0.0
19:37101626-37101626 C>T	1.0	4301	MELANOMA	-	-	-	-	ZNF382	uc002oel.3,p.P72S|ENST00000435416,p.P72S	retained_intron, protein_coding	uc002oel.3	nonsynonymous SNV	exon2	c.C214T	p.P72S	EQGEELWTQRIFPSYSYLEDGKTED	EQGEELWTQRIFSSYSYLEDGKTED	6.0	8.0	-	-	4301_19:37101626-37101626 C>T_EQGEELWTQRIFSSYSYLEDGKTED	0.0
6:147685193-147685193 G>A	0.0	4346	COLORECTAL	-	-	-	-	STXBP5	uc003qly.3,p.R646Q|ENST00000367480,p.R938Q|ENST00000321680,p.R991Q|uc010khz.2,p.R955Q|ENST00000179882,p.R646Q|NM_139244,p.R955Q|uc003qlz.3,p.R991Q|NM_001127715,p.R991Q|ENST00000367481,p.R955Q	protein_coding	uc010khz.2	nonsynonymous SNV	exon23	c.G2864A	p.R955Q	LLDVYYLPLTNMRIARTFCFTNNGQ	LLDVYYLPLTNMQIARTFCFTNNGQ	7.0	9.0	-	-	4346_6:147685193-147685193 G>A_LLDVYYLPLTNMQIARTFCFTNNGQ	0.0
9:42368614-42368614 A>G	0.0	4316	COLORECTAL	-	rs200348657	-	-	ANKRD20A2,ANKRD20A3	NM_001012421,p.H67R|uc004acd.3,p.H67R|ENST00000377601,p.H67R|NM_001012419,p.H67R|uc010mmv.3,p.H67R	protein_coding, processed_transcript	uc010mmv.3	nonsynonymous SNV	exon1	c.A200G	p.H67R	RRSGDLDALDKQHRTALHLACASGH	RRSGDLDALDKQRRTALHLACASGH	3.0	8.0	-	-	4316_9:42368614-42368614 A>G_RRSGDLDALDKQRRTALHLACASGH	0.0
18:47405409-47405409 T>A	1.0	4287	COLORECTAL	-	-	-	-	MYO5B	NM_001080467,p.E1061V|uc002lea.2,p.E202V|uc002leb.2,p.E1061V|ENST00000285039,p.E1061V|ENST00000324581,p.E202V	retained_intron, protein_coding, processed_transcript	uc002leb.2	nonsynonymous SNV	exon24	c.A3182T	p.E1061V	NSVKENLMKKELEEERSRYQNLVKE	NSVKENLMKKELVEERSRYQNLVKE	10.0	2.0	-	-	4287_18:47405409-47405409 T>A_NSVKENLMKKELVEERSRYQNLVKE	0.0
2:202571664-202571664 C>G	0.0	4335	COLORECTAL	-	-	-	-	ALS2	ENST00000264276,p.L1495F|NM_020919,p.L1495F|uc002uyo.3,p.L1495F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uyo.3	nonsynonymous SNV	exon29	c.G4485C	p.L1495F	PRLYPPLFMLYALDNDREEDIYWEC	PRLYPPLFMLYAFDNDREEDIYWEC	8.0	3.0	-	-	4335_2:202571664-202571664 C>G_PRLYPPLFMLYAFDNDREEDIYWEC	0.0
19:2193765-2193765 C>T	1.0	3713	MELANOMA	-	-	-	-	DOT1L	NM_032482,p.P191S|uc002lvb.4,p.P191S|ENST00000452696,p.P167S|ENST00000398665,p.P191S	retained_intron, protein_coding, processed_transcript	uc002lvb.4	nonsynonymous SNV	exon6	c.C571T	p.P191S	CKHHYGVEKADIPAKYAETMDREFR	CKHHYGVEKADISAKYAETMDREFR	6.0	6.0	-	-	3713_19:2193765-2193765 C>T_CKHHYGVEKADISAKYAETMDREFR	0.0
14:52186873-52186873 C>A	0.0	4335	COLORECTAL	-	-	-	-	FRMD6	NM_001267047,p.S17R|ENST00000555197,p.S105R|ENST00000344768,p.S375R|uc001wzd.3,p.S375R|uc001wze.3,p.S298R|NM_152330,p.S367R|ENST00000553556,p.S17R|uc001wzf.3,p.S68R|NM_001042481,p.S367R|ENST00000356218,p.S367R|ENST00000395718,p.S367R|uc001wzc.3,p.S367R|ENST00000555703,p.S17R|ENST00000554167,p.S298R|uc001wzb.4,p.S367R|uc001wzg.3,p.S17R|NM_001267046,p.S375R	retained_intron, protein_coding, processed_transcript	uc001wzg.3	nonsynonymous SNV	exon2	c.C51A	p.S17R	EKRSRASGSSAGSMKHKRLSRHSTA	EKRSRASGSSAGRMKHKRLSRHSTA	6.0	9.0	-	-	4335_14:52186873-52186873 C>A_EKRSRASGSSAGRMKHKRLSRHSTA	0.0
10:135053475-135053475 C>T	0.0	4329	COLORECTAL	-	-	-	-	VENTX	ENST00000325980,p.R148W|NM_014468,p.R148W|uc010quy.1,p.R148W	protein_coding	uc010quy.1	nonsynonymous SNV	exon3	c.C442T	p.R148W	KTWFQNRRMKHKRQMQDPQLHSPFS	KTWFQNRRMKHKWQMQDPQLHSPFS	1.0	6.0	-	-	4329_10:135053475-135053475 C>T_KTWFQNRRMKHKWQMQDPQLHSPFS	0.0
2:160295170-160295170 C>T	0.0	2591	MELANOMA	-	-	-	-	BAZ2B	ENST00000392782,p.G311R|ENST00000343439,p.G311R|uc002uao.3,p.G313R|NM_013450,p.G313R|ENST00000392783,p.G313R|uc002uas.1,p.G250R|uc010fop.1,p.G311R|uc002uap.3,p.G311R|ENST00000355831,p.G313R|uc002uau.1,p.G311R|uc002uaq.1,p.G241R|NM_001289975,p.G311R	retained_intron, protein_coding, processed_transcript	uc010fop.1	nonsynonymous SNV	exon7	c.G931A	p.G311R	VLLHGISDPKADGQKATEKAQEKRI	VLLHGISDPKADRQKATEKAQEKRI	7.0	4.0	-	-	2591_2:160295170-160295170 C>T_VLLHGISDPKADRQKATEKAQEKRI	0.0
10:13523048-13523048 G>A	1.0	3713	MELANOMA	-	-	-	-	BEND7	ENST00000396898,p.T318I|ENST00000396900,p.T305I|NM_001100912,p.T266I|NM_152751,p.T253I|uc001imm.2,p.T253I|uc001imn.3,p.T14I|ENST00000341083,p.T253I|uc001imo.4,p.T266I|ENST00000378605,p.T266I	protein_coding, processed_transcript	uc001imo.4	nonsynonymous SNV	exon5	c.C797T	p.T266I	PKSQLDSILSNYTRSGSLLFRKLVC	PKSQLDSILSNYIRSGSLLFRKLVC	1.0	4.0	-	-	3713_10:13523048-13523048 G>A_PKSQLDSILSNYIRSGSLLFRKLVC	0.0
19:4839259-4839259 A>G	1.0	4180	BREAST	-	-	-	-	PLIN3	ENST00000585479,p.L416P|NM_001164194,p.L405P|uc002mbj.2,p.L417P|NM_001164189,p.L416P|uc002mbl.3,p.L416P|NM_005817,p.L417P|uc002mbk.2,p.L405P|ENST00000221957,p.L417P|ENST00000592528,p.L405P	protein_coding	uc002mbl.3	nonsynonymous SNV	exon8	c.T1247C	p.L416P	VEYVAQNTPVTWLVGPFAPGITEKA	VEYVAQNTPVTWPVGPFAPGITEKA	10.0	9.0	-	-	4180_19:4839259-4839259 A>G_VEYVAQNTPVTWPVGPFAPGITEKA	0.0
16:67195814-67195816 CGC>-	1.0	4078	GASTRIC	-	-	-	-	FBXL8	ENST00000519945,p.42_43del	protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000519945	nonframeshift deletion	exon2	c.126_128del	p.42_43del	RVCRAWAAAATCSAVWHDTKISQPS	RVCRAWAAAATCSVWHDTKISQPSP	5.0	5.0	-	-	4078_16:67195814-67195816 CGC>-_RVCRAWAAAATCSVWHDTKISQPSP	0.0
11:6238409-6238409 G>A	1.0	2556	MELANOMA	-	-	-	-	FAM160A2	uc001mcm.2,p.H803Y|ENST00000524416,p.H803Y	protein_coding, processed_transcript	uc001mcm.2	nonsynonymous SNV	exon9	c.C2407T	p.H803Y	SYLCPCVCLYVFHACAGLSIDLHLS	SYLCPCVCLYVFYACAGLSIDLHLS	6.0	2.0	-	-	2556_11:6238409-6238409 G>A_SYLCPCVCLYVFYACAGLSIDLHLS	0.0
2:179534397-179534397 C>T	0.0	4275	COLORECTAL	-	-	-	-	TTN	NM_001267550,p.E11798K|uc031rqc.1,p.E11798K|ENST00000589042,p.E11798K	retained_intron, protein_coding	uc031rqc.1	nonsynonymous SNV	exon158	c.G35392A	p.E11798K	PEEPRVPPTKAPEVPKKIVPEEKVR	PEEPRVPPTKAPKVPKKIVPEEKVR	7.0	7.0	-	-	4275_2:179534397-179534397 C>T_PEEPRVPPTKAPKVPKKIVPEEKVR	0.0
7:48390282-48390282 G>A	1.0	4213	COLORECTAL	-	-	-	-	ABCA13	uc010kys.2,p.R1097H|uc031sxh.1,p.R1097H|uc003tos.1,p.R242H|uc003toq.2,p.R3416H|uc031sxg.1,p.R1097H|NM_152701,p.R3416H|ENST00000435803,p.R3416H	retained_intron, protein_coding, nonsense_mediated_decay	uc031sxh.1	nonsynonymous SNV	exon13	c.G3290A	p.R1097H	LLDEMFNHAGAGRFRFLGSILVNLS	LLDEMFNHAGAGHFRFLGSILVNLS	5.0	10.0	-	-	4213_7:48390282-48390282 G>A_LLDEMFNHAGAGHFRFLGSILVNLS	0.0
19:39219953-39219953 C>T	1.0	3879	MELANOMA	-	-	-	-	ACTN4	ENST00000440400,p.P304S|uc021uug.1,p.P654S|ENST00000252699,p.P873S|ENST00000424234,p.P483S|NM_004924,p.P873S|uc002oja.2,p.P873S|ENST00000390009,p.P654S	retained_intron, protein_coding, processed_transcript	uc021uug.1	nonsynonymous SNV	exon14	c.C1960T	p.P654S	FITAEELRRELPPDQAEYCIARMAP	FITAEELRRELPSDQAEYCIARMAP	10.0	2.0	-	-	3879_19:39219953-39219953 C>T_FITAEELRRELPSDQAEYCIARMAP	0.0
12:57499285-57499285 G>A	1.0	4240	BREAST	-	-	-	1	STAT6	ENST00000454075,p.R260W|NM_001178080,p.R150W|ENST00000300134,p.R260W|ENST00000538913,p.R150W|uc010srb.2,p.R150W|NM_003153,p.R260W|uc010src.2,p.R150W|ENST00000556155,p.R260W|uc009zpg.3,p.R309W|NM_001178079,p.R260W|uc009zpe.3,p.R260W|uc010srd.2,p.R150W|ENST00000543873,p.R260W|NM_001178081,p.R150W|ENST00000537215,p.R150W|uc009zpf.3,p.R260W|uc001sna.3,p.R260W|NM_001178078,p.R260W	retained_intron, protein_coding, nonsense_mediated_decay	uc010srd.2	nonsynonymous SNV	exon6	c.C448T	p.R150W	ELEPKTRASLTGRLDEVLRTLVTSC	ELEPKTRASLTGWLDEVLRTLVTSC	10.0	3.0	-	-	4240_12:57499285-57499285 G>A_ELEPKTRASLTGWLDEVLRTLVTSC	0.0
2:74642085-74642085 C>T	1.0	4246	COLORECTAL	-	-	-	-	C2orf81	NM_001145054,p.G380R|ENST00000290390,p.G380R|ENST00000517883,p.G312R|uc010yrq.1,p.G380R	protein_coding	uc010yrq.1	nonsynonymous SNV	exon4	c.G1138A	p.G380R	PDSQTRPLEAYRGRQRGEKTKARAE	PDSQTRPLEAYRRRQRGEKTKARAE	5.0	6.0	-	-	4246_2:74642085-74642085 C>T_PDSQTRPLEAYRRRQRGEKTKARAE	0.0
12:52380736-52380736 T>C	1.0	3713	MELANOMA	-	-	-	-	ACVR1B	uc001rzl.3,p.L424P|ENST00000415850,p.L424P	protein_coding, processed_transcript, nonsense_mediated_decay	uc001rzl.3	nonsynonymous SNV	exon7	c.T1271C	p.L424P	EIARRCNSGGTFLFCLCSYLPFQDA	EIARRCNSGGTFPFCLCSYLPFQDA	6.0	5.0	-	-	3713_12:52380736-52380736 T>C_EIARRCNSGGTFPFCLCSYLPFQDA	0.0
5:176943295-176943295 C>G	0.0	4110	BILE DUCT	-	-	-	-	DDX41	ENST00000330503,p.A116P|ENST00000507955,p.A98P|NM_016222,p.A98P|uc003mho.3,p.A98P|ENST00000509576,p.A98P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003mho.3	nonsynonymous SNV	exon3	c.G292C	p.A98P	SLLDQHQHLKEKAEARKESAKEKQL	SLLDQHQHLKEKPEARKESAKEKQL	9.0	5.0	-	-	4110_5:176943295-176943295 C>G_SLLDQHQHLKEKPEARKESAKEKQL	0.0
9:5463085-5463085 C>T	1.0	4000	MELANOMA	-	-	-	1	CD274	NM_014143,p.P216S|uc003zje.3,p.P216S|NM_001267706,p.P102S|ENST00000381573,p.P102S|ENST00000381577,p.P216S|uc003zjf.4,p.P102S	protein_coding, processed_transcript	uc003zjf.4	nonsynonymous SNV	exon3	c.C304T	p.P102S	NEIFYCTFRRLDPEENHTAELVIPE	NEIFYCTFRRLDSEENHTAELVIPE	7.0	10.0	-	-	4000_9:5463085-5463085 C>T_NEIFYCTFRRLDSEENHTAELVIPE	0.0
5:156934131-156934131 C>T	0.0	4155	MELANOMA	-	-	-	-	ADAM19	ENST00000517905,p.G308D|uc003lwz.4,p.G308D|ENST00000257527,p.G308D|uc003lww.3,p.G41D|NM_033274,p.G308D|uc011ddr.1,p.G239D|ENST00000394020,p.G310D|ENST00000430702,p.G41D	retained_intron, protein_coding, nonsense_mediated_decay	uc011ddr.1	nonsynonymous SNV	exon10	c.G716A	p.G239D	DNAQLITGMSFHGTTIGLAPLMAMC	DNAQLITGMSFHDTTIGLAPLMAMC	4.0	10.0	-	-	4155_5:156934131-156934131 C>T_DNAQLITGMSFHDTTIGLAPLMAMC	0.0
X:26157208-26157208 G>C	0.0	3775	CERVICAL	-	-	ID=COSM3965072;OCCURENCE=1(lung)	-	MAGEB18	ENST00000325250,p.E36Q|uc022bub.1,p.E36Q	protein_coding	uc022bub.1	nonsynonymous SNV	exon1	c.G106C	p.E36Q	DLGATQATVAEGESPSPAYLLFGDR	DLGATQATVAEGQSPSPAYLLFGDR	1.0	7.0	-	-	3775_X:26157208-26157208 G>C_DLGATQATVAEGQSPSPAYLLFGDR	0.0
19:33904513-33904513 C>A	1.0	4129	NSCLC	-	-	-	-	PEPD	uc010xrs.2,p.M172I|ENST00000593163,p.M129I|NM_001166057,p.M172I|ENST00000436370,p.M172I|ENST00000244137,p.M236I|uc002nur.4,p.M236I|NM_000285,p.M236I	retained_intron, protein_coding, lincRNA	uc010xrs.2	nonsynonymous SNV	exon8	c.G516T	p.M172I	SLFEHYCYSRGGMRHSSYTCICGSG	SLFEHYCYSRGGIRHSSYTCICGSG	10.0	3.0	-	-	4129_19:33904513-33904513 C>A_SLFEHYCYSRGGIRHSSYTCICGSG	0.0
19:49963010-49963010 G>A	1.0	4237	NSCLC	-	-	-	-	ALDH16A1	NM_001145396,p.R135Q|NM_153329,p.R135Q|ENST00000293350,p.R135Q|uc002pnt.3,p.R135Q|ENST00000455361,p.R135Q|uc010yar.2,p.R135Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yar.2	nonsynonymous SNV	exon4	c.G404A	p.R135Q	ESLVTGRAVREVRDGDVQLAQQLLH	ESLVTGRAVREVQDGDVQLAQQLLH	9.0	3.0	-	-	4237_19:49963010-49963010 G>A_ESLVTGRAVREVQDGDVQLAQQLLH	0.0
3:130852674-130852674 G>A	0.0	3919	MELANOMA	-	-	-	-	NEK11	ENST00000412440,p.G26E|ENST00000510769,p.G174E|uc010hto.2,p.G26E|uc011blm.2,p.G174E|ENST00000510688,p.G174E|uc011blk.2,p.G26E|ENST00000383366,p.G174E|uc003enw.1,p.G174E|uc003eoa.3,p.G174E|NM_024800,p.G174E|ENST00000508196,p.G174E|ENST00000429253,p.G174E|uc003enx.3,p.G174E|ENST00000511262,p.G174E|uc003eny.3,p.G174E|uc011bll.2,p.G174E|ENST00000507910,p.G174E|ENST00000356918,p.G174E|NM_145910,p.G174E|NM_001146003,p.G174E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011blm.2	nonsynonymous SNV	exon6	c.G521A	p.G174E	KNVFLKNNLLKIGDFGVSRLLMGSC	KNVFLKNNLLKIEDFGVSRLLMGSC	3.0	4.0	-	-	3919_3:130852674-130852674 G>A_KNVFLKNNLLKIEDFGVSRLLMGSC	0.0
1:247586622-247586622 C>T	0.0	3795	MELANOMA	-	-	-	-	NLRP3	NM_004895,p.S125L|ENST00000348069,p.S125L|uc001ics.3,p.S125L|NM_183395,p.S125L|ENST00000391828,p.S125L|ENST00000366496,p.S125L|uc001icw.3,p.S125L|ENST00000336119,p.S125L|NM_001079821,p.S125L|uc001ict.1,p.S123L|uc001icu.3,p.S125L|uc010pyw.2,p.S123L|NM_001243133,p.S123L|ENST00000366497,p.S125L|uc001icv.3,p.S125L|uc001icr.3,p.S125L|NM_001127461,p.S125L|ENST00000391827,p.S125L|NM_001127462,p.S125L	protein_coding, processed_transcript	uc010pyw.2	nonsynonymous SNV	exon2	c.C368T	p.S123L	IEEEWMGLLEYLSRISICKMKKDYR	IEEEWMGLLEYLLRISICKMKKDYR	5.0	2.0	-	-	3795_1:247586622-247586622 C>T_IEEEWMGLLEYLLRISICKMKKDYR	0.0
1:159277714-159277714 A>C	0.0	4246	COLORECTAL	-	-	-	-	FCER1A	NM_002001,p.N256H|ENST00000368115,p.N256H|uc001ftq.3,p.N256H|ENST00000368114,p.N223H	protein_coding	uc001ftq.3	nonsynonymous SNV	exon6	c.A766C	p.N256H	RLLNPHPKPNPKNN	RLLNPHPKPNPKHN	4.0	2.0	-	-	4246_1:159277714-159277714 A>C_RLLNPHPKPNPKHN	0.0
22:19220085-19220085 C>G	1.0	4213	COLORECTAL	-	-	-	1	CLTCL1	NM_001835,p.G520R|uc021wlc.1,p.G520R|NM_007098,p.G520R|ENST00000505027,p.G520R|ENST00000353891,p.G520R|ENST00000263200,p.G520R|uc011agw.1,p.G520R|uc021wle.1,p.G520R|uc021wlf.1,p.G520R|uc021wld.1,p.G520R|ENST00000427926,p.G520R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wlf.1	nonsynonymous SNV	exon10	c.G1558C	p.G520R	VGYTPDWIFLLRGVMKISPEQGLQF	VGYTPDWIFLLRRVMKISPEQGLQF	6.0	10.0	-	-	4213_22:19220085-19220085 C>G_VGYTPDWIFLLRRVMKISPEQGLQF	0.0
12:131488763-131488763 G>A	0.0	4259	COLORECTAL	-	-	-	-	GPR133	ENST00000376682,p.V79M|ENST00000544673,p.V84M|NM_198827,p.V393M|ENST00000535015,p.V425M|uc010tbm.2,p.V425M|uc001uit.4,p.V393M|ENST00000261654,p.V393M|ENST00000545900,p.V89M	retained_intron, protein_coding, processed_transcript	uc010tbm.2	nonsynonymous SNV	exon12	c.G1273A	p.V425M	AEFSVAKILPKTVNSSHYRFPAHGQ	AEFSVAKILPKTMNSSHYRFPAHGQ	5.0	5.0	-	-	4259_12:131488763-131488763 G>A_AEFSVAKILPKTMNSSHYRFPAHGQ	0.0
2:50850710-50850710 G>-	0.0	4078	GASTRIC	-	-	-	-	NRXN1	NM_004801,p.F292fs|ENST00000405472,p.F292fs|uc021vhg.1,p.F325fs|uc021vhi.1,p.F321fs|uc021vhj.1,p.F288fs|uc021vhh.1,p.F292fs|ENST00000406316,p.F292fs|ENST00000402717,p.F292fs|ENST00000406859,p.F292fs|NM_001135659,p.F325fs|ENST00000401669,p.F292fs|ENST00000404971,p.F325fs	retained_intron, protein_coding, processed_transcript	uc021vhj.1	frameshift deletion	exon5	c.864delC	p.F288fs	EEYIATFKGSEYFCYDLSQNPIQSS	EEYIATFKGSEYFATTCLKTPFKAAVMK	1.0	1.0	-	-	4078_2:50850710-50850710 G>-_EEYIATFKGSEYFATTCLKTPFKAAVMK	0.0
20:44333611-44333611 C>A	0.0	4301	MELANOMA	-	-	-	-	WFDC10B	ENST00000335769,p.R7M|uc002xpc.3,p.R7M|NM_172131,p.R7M	protein_coding	uc002xpc.3	nonsynonymous SNV	exon1	c.G20T	p.R7M	MVSCERRASKSVGQILLWD	MVSCERMASKSVGQILLWD	4.0	4.0	-	-	4301_20:44333611-44333611 C>A_MVSCERMASKSVGQILLWD	0.0
13:37598227-37598228 GA>-	1.0	4317	COLORECTAL	-	-	-	-	SUPT20H	ENST00000464744,p.L513fs|ENST00000542180,p.L476fs|uc010abt.3,p.L513fs|NM_001278482,p.L513fs|ENST00000495071,p.L476fs|NM_001278480,p.L512fs|uc001uwl.1,p.L512fs|uc010tes.1,p.L476fs|NM_001278481,p.L513fs|ENST00000475892,p.L512fs|uc001uwf.3,p.L90fs|ENST00000356185,p.L513fs|ENST00000350612,p.L512fs|uc001uwg.3,p.L512fs|NM_001014286,p.L512fs|NM_017569,p.L513fs|uc001uwh.3,p.L513fs|uc001uwi.3,p.L512fs|ENST00000490716,p.L500fs|ENST00000360252,p.L513fs|uc001uwk.3,p.L512fs|uc001uwj.3,p.L513fs	retained_intron, protein_coding, processed_transcript	uc010tes.1	frameshift deletion	exon17	c.1427_1428del	p.L476fs	KPSSIPRKSSVDLNQVSMLSPAALS	KPSSIPRKSSVDQSS	10.0	3.0	-	-	4317_13:37598227-37598228 GA>-_KPSSIPRKSSVDQSS	0.0
1:216420343-216420343 T>A	0.0	4196	COLORECTAL	-	-	-	-	USH2A	ENST00000366942,p.D798V|NM_007123,p.D798V|ENST00000366943,p.D798V|NM_206933,p.D798V|ENST00000307340,p.D798V|uc001hkv.3,p.D798V|uc001hku.1,p.D798V	retained_intron, protein_coding	uc001hkv.3	nonsynonymous SNV	exon13	c.A2393T	p.D798V	GLDVTNCKACDCDTAGSLPGTVCNA	GLDVTNCKACDCVTAGSLPGTVCNA	3.0	3.0	-	-	4196_1:216420343-216420343 T>A_GLDVTNCKACDCVTAGSLPGTVCNA	0.0
12:113319613-113319613 C>T	0.0	4301	MELANOMA	-	-	-	-	RPH3A	ENST00000389385,p.P430S|uc010sym.2,p.P381S|uc001ttz.3,p.P430S|ENST00000543106,p.P430S|NM_014954,p.P426S|uc010syl.2,p.P430S|uc009zwe.1,p.P426S|NM_001143854,p.P430S|uc001tty.3,p.P426S|ENST00000551052,p.P426S|ENST00000548866,p.P381S|ENST00000447659,p.P381S|ENST00000420983,p.P430S|ENST00000415485,p.P430S|uc001tua.3,p.P190S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sym.2	nonsynonymous SNV	exon13	c.C1141T	p.P381S	GLKPMDSNGLADPYVKLHLLPGASK	GLKPMDSNGLADSYVKLHLLPGASK	3.0	1.0	-	-	4301_12:113319613-113319613 C>T_GLKPMDSNGLADSYVKLHLLPGASK	0.0
8:95502281-95502281 C>T	1.0	4000	MELANOMA	-	-	-	-	KIAA1429	uc003ygo.2,p.G1724S|NM_015496,p.G1724S|ENST00000297591,p.G1724S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ygo.2	nonsynonymous SNV	exon23	c.G5170A	p.G1724S	SKGNYSRREGTRGSSWSAQNTPRGN	SKGNYSRREGTRSSSWSAQNTPRGN	9.0	10.0	-	-	4000_8:95502281-95502281 C>T_SKGNYSRREGTRSSSWSAQNTPRGN	0.0
2:182403913-182403913 G>A	0.0	2556	MELANOMA	-	-	-	-	CERKL	uc021vti.1,p.P230S|uc021vtj.1,p.P185S|uc021vtk.1,p.P230S|uc002unw.3,p.P78S|uc002unz.3,p.P230S|ENST00000374970,p.P413S|uc021vth.1,p.P277S|NM_001030313,p.P413S|uc002uny.3,p.P482S|uc021vtm.2,p.P277S|uc010zfm.2,p.P464S|uc002uoc.3,p.P369S|NM_001030312,p.P369S|uc002uod.3,p.P277S|NM_201548,p.P482S|uc002uoa.3,p.P413S|ENST00000339098,p.P508S|ENST00000410087,p.P482S|ENST00000409440,p.P464S|uc021vtl.1,p.P185S|NM_001160277,p.P464S|uc002unx.3,p.P508S|uc010frk.4,p.P174S|ENST00000374969,p.P369S|NM_001030311,p.P508S|uc002uob.3,p.P230S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021vtm.2	nonsynonymous SNV	exon13	c.C829T	p.P277S	KVHPRNNTGGYNPEEEEDETASENC	KVHPRNNTGGYNSEEEEDETASENC	3.0	6.0	-	-	2556_2:182403913-182403913 G>A_KVHPRNNTGGYNSEEEEDETASENC	0.0
13:96547548-96547548 G>A	1.0	3678	MELANOMA	-	-	-	-	UGGT2	ENST00000376747,p.P882L|NM_020121,p.P882L|uc001vmt.3,p.P882L	retained_intron, protein_coding, processed_transcript	uc001vmt.3	nonsynonymous SNV	exon23	c.C2645T	p.P882L	EMGIVSNGRFLGPLDEDFYAEDFYL	EMGIVSNGRFLGLLDEDFYAEDFYL	9.0	10.0	CD8	-	3678_13:96547548-96547548 G>A_EMGIVSNGRFLGLLDEDFYAEDFYL	1.0
4:7684503-7684503 ->A	0.0	4245	COLORECTAL	-	-	-	-	SORCS2	uc003gkb.4,p.Q459fs|NM_020777,p.Q459fs|ENST00000507866,p.Q459fs|uc011bwi.2,p.Q287fs|ENST00000329016,p.Q287fs	protein_coding, processed_transcript	uc011bwi.2	frameshift insertion	exon10	c.860dupA	p.Q287fs	EVRGVKGVFLANQKIDGKVMTLITY	EVRGVKGVFLANQKN	4.0	6.0	-	-	4245_4:7684503-7684503 ->A_EVRGVKGVFLANQKN	0.0
22:30824484-30824484 A>C	1.0	4320	COLORECTAL	-	-	-	-	MTFP1	ENST00000355143,p.Q77H|uc003ahx.2,p.Q77H|NM_001003704,p.Q77H	 protein_coding,retained_intron, nonsense_mediated_decay	uc003ahx.2	nonsynonymous SNV	exon3	c.A231C	p.Q77H	EVGGFPPGLQPAQALPNSGEAQLLL	EVGGFPPGLQPAHALPNSGEAQLLL	6.0	4.0	-	-	4320_22:30824484-30824484 A>C_EVGGFPPGLQPAHALPNSGEAQLLL	0.0
19:8188736-8188736 G>T	0.0	4326	BREAST	-	-	-	-	FBN3	ENST00000601739,p.A963D|ENST00000270509,p.A963D|ENST00000600128,p.A963D|NM_032447,p.A963D|uc002mjf.3,p.A963D	retained_intron, protein_coding	uc002mjf.3	nonsynonymous SNV	exon22	c.C2888A	p.A963D	CEACPDPESLEFASLCPRGLGFASR	CEACPDPESLEFDSLCPRGLGFASR	4.0	6.0	-	-	4326_19:8188736-8188736 G>T_CEACPDPESLEFDSLCPRGLGFASR	0.0
17:7577094-7577094 G>A	1.0	4244	COLORECTAL	-	-	ID=COSM3378339,COSM99925,COSM1636702,COSM10704;OCCURENCE=17(ovary),3(endometrium),1(salivary_gland),9(skin),22(breast),2(prostate),148(large_intestine),4(biliary_tract),12(urinary_tract),5(liver),17(pancreas),1(thymus),36(central_nervous_system),34(stomach),4(vulva),55(oesophagus),37(upper_aerodigestive_tract),2(bone),2(thyroid),20(lung),2(peritoneum),7(haematopoietic_and_lymphoid_tissue)	1	TP53	uc002gih.3,p.R282W|NM_000546,p.R282W|NM_001126112,p.R282W|ENST00000445888,p.R282W|uc031qyq.1,p.R243W|NM_001126117,p.R150W|NM_001276699,p.R123W|ENST00000359597,p.R282W|NM_001126114,p.R282W|NM_001276697,p.R123W|NM_001126116,p.R150W|ENST00000455263,p.R282W|uc010cnf.2,p.R123W|uc002gii.2,p.R123W|NM_001276760,p.R243W|NM_001126113,p.R282W|NM_001126118,p.R243W|NM_001276696,p.R243W|ENST00000269305,p.R282W|NM_001276698,p.R123W|uc002gij.3,p.R243W|NM_001276695,p.R243W|uc010cng.2,p.R123W|NM_001126115,p.R150W|ENST00000509690,p.R150W|ENST00000420246,p.R282W|NM_001276761,p.R243W	retained_intron, protein_coding, processed_transcript	uc031qyq.1	nonsynonymous SNV	exon7	c.C727T	p.R243W	FEVRVCACPGRDRRTEEENLRKKGE	FEVRVCACPGRDWRTEEENLRKKGE	9.0	10.0	-	-	4244_17:7577094-7577094 G>A_FEVRVCACPGRDWRTEEENLRKKGE	0.0
6:158094126-158094126 G>A	1.0	4284	COLORECTAL	-	-	ID=COSM3697632;OCCURENCE=1(large_intestine)	-	ZDHHC14	uc003qqs.3,p.R465H|uc010kjn.3,p.R135H|NM_024630,p.R480H|NM_153746,p.R465H|ENST00000414563,p.R465H|ENST00000359775,p.R480H|uc003qqt.3,p.R480H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kjn.3	nonsynonymous SNV	exon5	c.G404A	p.R135H	LASQDSLHEDSVRGLVKLSSV	LASQDSLHEDSVHGLVKLSSV	6.0	9.0	-	-	4284_6:158094126-158094126 G>A_LASQDSLHEDSVHGLVKLSSV	0.0
5:63256386-63256386 C>A	0.0	4284	COLORECTAL	-	-	-	-	HTR1A	uc011cqt.3,p.W387C|NM_000524,p.W387C|ENST00000323865,p.W387C	protein_coding	uc011cqt.3	nonsynonymous SNV	exon1	c.G1161T	p.W387C	CHMPTLLGAIINWLGYSNSLLNPVI	CHMPTLLGAIINCLGYSNSLLNPVI	2.0	9.0	-	-	4284_5:63256386-63256386 C>A_CHMPTLLGAIINCLGYSNSLLNPVI	0.0
12:119961610-119961610 G>A	0.0	2591	MELANOMA	-	-	-	-	CCDC60	uc001txe.3,p.E406K|NM_178499,p.E406K|ENST00000327554,p.E406K	protein_coding, processed_transcript	uc001txe.3	nonsynonymous SNV	exon11	c.G1216A	p.E406K	AQEAGFCLQDKMEILMKRQEERGIQ	AQEAGFCLQDKMKILMKRQEERGIQ	1.0	10.0	-	-	2591_12:119961610-119961610 G>A_AQEAGFCLQDKMKILMKRQEERGIQ	0.0
19:18120604-18120604 C>T	1.0	3998	MELANOMA	-	-	-	-	ARRDC2	uc002nhv.3,p.P202L|ENST00000379656,p.P197L|NM_001025604,p.P197L|uc002nhu.3,p.P197L|NM_001286826,p.P202L|NM_015683,p.P202L|ENST00000222250,p.P202L	retained_intron, protein_coding, processed_transcript	uc002nhv.3	nonsynonymous SNV	exon5	c.C605T	p.P202L	IDRKGYTPGEVIPVFAEIDNGSTRP	IDRKGYTPGEVILVFAEIDNGSTRP	7.0	6.0	-	-	3998_19:18120604-18120604 C>T_IDRKGYTPGEVILVFAEIDNGSTRP	0.0
22:32134612-32134612 T>G	1.0	4335	COLORECTAL	-	-	-	-	PRR14L	ENST00000412743,p.T79P|ENST00000397493,p.T79P|uc003alp.4,p.T79P|ENST00000434485,p.T79P|ENST00000327423,p.T79P|NM_173566,p.T79P	protein_coding, processed_transcript, nonsense_mediated_decay	uc003alp.4	nonsynonymous SNV	exon2	c.A235C	p.T79P	LQRTHVESCCEETYETLDHGSEPGR	LQRTHVESCCEEPYETLDHGSEPGR	9.0	2.0	-	-	4335_22:32134612-32134612 T>G_LQRTHVESCCEEPYETLDHGSEPGR	0.0
22:29876852-29876852 G>A	0.0	4326	BREAST	-	-	-	-	NEFH	ENST00000310624,p.A201T|uc003afo.3,p.A201T|NM_021076,p.A201T	protein_coding	uc003afo.3	nonsynonymous SNV	exon1	c.G601A	p.A201T	ARQREEAEAAARALARFAQEAEAAR	ARQREEAEAAARTLARFAQEAEAAR	5.0	8.0	-	-	4326_22:29876852-29876852 G>A_ARQREEAEAAARTLARFAQEAEAAR	0.0
5:138378367-138378367 T>C	1.0	4213	COLORECTAL	-	-	-	-	SIL1	ENST00000509534,p.K139R|NM_001037633,p.K132R|uc003ldo.3,p.K132R|uc003ldp.3,p.K132R|ENST00000265195,p.K132R|ENST00000508639,p.K132R|ENST00000394817,p.K132R|NM_022464,p.K132R	protein_coding, processed_transcript	uc003ldp.3	nonsynonymous SNV	exon5	c.A395G	p.K132R	DINTNTYTSQDLKSALAKFKEGAEM	DINTNTYTSQDLRSALAKFKEGAEM	10.0	5.0	-	-	4213_5:138378367-138378367 T>C_DINTNTYTSQDLRSALAKFKEGAEM	0.0
4:47538713-47538713 C>T	0.0	3713	MELANOMA	-	-	-	-	ATP10D	uc003gxk.1,p.P385L|ENST00000273859,p.P385L|NM_020453,p.P385L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gxk.1	nonsynonymous SNV	exon9	c.C1154T	p.P385L	FWTMIILLQVLIPISLYVSIEIVKL	FWTMIILLQVLILISLYVSIEIVKL	5.0	7.0	-	-	3713_4:47538713-47538713 C>T_FWTMIILLQVLILISLYVSIEIVKL	0.0
20:43726631-43726631 C>T	0.0	4284	COLORECTAL	-	-	-	-	KCNS1	uc002xnd.3,p.R261H|uc002xnc.3,p.R261H|ENST00000537075,p.R261H|NM_002251,p.R261H|ENST00000306117,p.R261H	protein_coding	uc002xnd.3	nonsynonymous SNV	exon3	c.G782A	p.R261H	EAAAAVAAVAAGRSPEGVRDDPVLR	EAAAAVAAVAAGHSPEGVRDDPVLR	4.0	2.0	-	-	4284_20:43726631-43726631 C>T_EAAAAVAAVAAGHSPEGVRDDPVLR	0.0
9:114199363-114199363 G>A	1.0	4136	BREAST	-	-	-	-	KIAA0368	ENST00000602447,p.R195C|NM_001080398,p.R367C|ENST00000338205,p.R189C|ENST00000259335,p.R367C|uc010muc.1,p.R189C|uc004bfe.1,p.R367C	protein_coding, processed_transcript	uc010muc.1	nonsynonymous SNV	exon7	c.C565T	p.R189C	MPYGYVLNESQSRQNSSSAQGSSSN	MPYGYVLNESQSCQNSSSAQGSSSN	10.0	4.0	-	-	4136_9:114199363-114199363 G>A_MPYGYVLNESQSCQNSSSAQGSSSN	0.0
9:79318741-79318741 G>T	0.0	4129	NSCLC	-	-	-	-	PRUNE2	NM_015225,p.D2596E|uc022bih.1,p.D2418E|uc004akj.4,p.D49E|ENST00000376718,p.D2596E|uc010mpl.1,p.D49E|ENST00000428286,p.D2237E|uc010mpk.3,p.D2596E	protein_coding, processed_transcript	uc022bih.1	nonsynonymous SNV	exon8	c.C7254A	p.D2418E	TGLQGTQLASFPDTCQPASLNERKG	TGLQGTQLASFPETCQPASLNERKG	4.0	10.0	-	-	4129_9:79318741-79318741 G>T_TGLQGTQLASFPETCQPASLNERKG	0.0
21:37661492-37661492 C>T	1.0	2369	MELANOMA	-	-	-	-	DOPEY2	ENST00000399151,p.P2168L|uc002yvg.3,p.P2168L|uc011aeb.2,p.P2117L|NM_005128,p.P2168L	retained_intron, protein_coding, processed_transcript	uc011aeb.2	nonsynonymous SNV	exon33	c.C6350T	p.P2117L	LDTALSFPPDKMPLFQIYRWAFIPE	LDTALSFPPDKMLLFQIYRWAFIPE	6.0	3.0	CD8	-	2369_21:37661492-37661492 C>T_LDTALSFPPDKMLLFQIYRWAFIPE	1.0
16:54967102-54967102 T>G	0.0	4298	COLORECTAL	-	-	-	-	IRX5	NM_005853,p.S257A|ENST00000394636,p.S257A|uc002ehv.3,p.S257A|uc021tin.1,p.S256A|ENST00000320990,p.S256A|uc002ehw.3,p.S191A|ENST00000558597,p.S191A|NM_001252197,p.S256A	protein_coding	uc021tin.1	nonsynonymous SNV	exon3	c.T766G	p.S256A	GSLSDSDFKEPPSEGRLDALQGPPR	GSLSDSDFKEPPAEGRLDALQGPPR	5.0	6.0	-	-	4298_16:54967102-54967102 T>G_GSLSDSDFKEPPAEGRLDALQGPPR	0.0
7:42005847-42005847 G>C	0.0	4158	COLORECTAL	-	-	-	-	GLI3	NM_000168,p.P942A|uc011kbh.2,p.P942A|uc011kbg.2,p.P883A|ENST00000395925,p.P942A	retained_intron, protein_coding, processed_transcript	uc011kbh.2	nonsynonymous SNV	exon15	c.C2824G	p.P942A	KAKYAAATGGPPPTPLPNMERMSLK	KAKYAAATGGPPATPLPNMERMSLK	6.0	4.0	-	-	4158_7:42005847-42005847 G>C_KAKYAAATGGPPATPLPNMERMSLK	0.0
10:55663064-55663064 T>G	0.0	4266	COLORECTAL	-	-	-	-	PCDH15	NM_001142764,p.K1147T|uc010qhq.2,p.K1152T|ENST00000320301,p.K1147T|uc021pqw.1,p.K1159T|ENST00000414778,p.K1152T|uc010qhr.2,p.K1147T|uc010qhw.1,p.K1110T|ENST00000361849,p.K1147T|uc021pqz.1,p.K1125T|ENST00000395432,p.K1110T|NM_033056,p.K1147T|uc010qhz.1,p.K1147T|NM_001142767,p.K1110T|uc010qib.1,p.K1125T|NM_001142763,p.K1152T|uc021pqy.1,p.K1147T|NM_001142773,p.K1125T|NM_001142765,p.K1076T|ENST00000395445,p.K1154T|uc010qhv.1,p.K1147T|uc010qia.1,p.K1125T|ENST00000373965,p.K1154T|uc010qht.2,p.K1154T|ENST00000437009,p.K1076T|ENST00000395430,p.K1147T|NM_001142766,p.K1147T|uc021pqx.1,p.K1147T|uc001jju.1,p.K1147T|uc021pqv.1,p.K1147T|ENST00000395438,p.K1147T|ENST00000409834,p.K758T|NM_001142768,p.K1125T|ENST00000395433,p.K1125T|uc010qhy.1,p.K1152T|uc010qhx.1,p.K1076T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021pqz.1	nonsynonymous SNV	exon24	c.A3374C	p.K1125T	QDENNHPPVFQKKFYIGGVSEDARM	QDENNHPPVFQKTFYIGGVSEDARM	4.0	1.0	-	-	4266_10:55663064-55663064 T>G_QDENNHPPVFQKTFYIGGVSEDARM	0.0
X:70354226-70354226 C>T	0.0	4158	COLORECTAL	-	-	-	1	MED12	uc004dyy.3,p.T1546M|ENST00000439750,p.T291M|ENST00000333646,p.T1546M|ENST00000374080,p.T1546M|uc010nla.3,p.T172M|ENST00000374102,p.T1546M|uc011mpq.1,p.T1546M|NM_005120,p.T1546M|uc004dza.3,p.T1393M|ENST00000430072,p.T1514M|uc004dyz.3,p.T1546M	protein_coding, processed_transcript	uc011mpq.1	nonsynonymous SNV	exon34	c.C4637T	p.T1546M	KLRLNLVGGMFDTVQRSTQQTTEWA	KLRLNLVGGMFDMVQRSTQQTTEWA	7.0	8.0	-	-	4158_X:70354226-70354226 C>T_KLRLNLVGGMFDMVQRSTQQTTEWA	0.0
12:69127366-69127366 G>A	1.0	3713	MELANOMA	-	-	-	-	NUP107	ENST00000229179,p.E746K|uc001suf.3,p.E746K|uc001sug.3,p.E505K|NM_020401,p.E746K|uc010stj.2,p.E717K|ENST00000378905,p.E507K|ENST00000539906,p.E717K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010stj.2	nonsynonymous SNV	exon24	c.G2149A	p.E717K	SPLPAEDDNAIREHLCIRAYLEAHE	SPLPAEDDNAIRKHLCIRAYLEAHE	7.0	4.0	-	-	3713_12:69127366-69127366 G>A_SPLPAEDDNAIRKHLCIRAYLEAHE	0.0
7:143884697-143884697 C>G	1.0	4244	COLORECTAL	-	-	-	-	ARHGEF35	NM_001003702,p.Q260H|ENST00000378115,p.Q260H|ENST00000543357,p.Q260H|uc022aog.1,p.Q260H|uc003wdz.2,p.Q260H	protein_coding	uc022aog.1	nonsynonymous SNV	exon1	c.G780C	p.Q260H	EDVCADGLLGEEQMIEQVNDEKGEQ	EDVCADGLLGEEHMIEQVNDEKGEQ	7.0	4.0	-	-	4244_7:143884697-143884697 C>G_EDVCADGLLGEEHMIEQVNDEKGEQ	0.0
17:36718116-36718116 T>A	0.0	4245	COLORECTAL	-	-	-	-	SRCIN1	uc002hqd.3,p.K428M|ENST00000264659,p.K428M|uc002hqf.1,p.K300M|ENST00000578925,p.K462M|NM_025248,p.K428M|uc002hqh.1,p.K488M|uc002hqe.2,p.K282M	retained_intron, protein_coding, processed_transcript	uc002hqh.1	nonsynonymous SNV	exon7	c.A1463T	p.K488M	DPFAYPGAGGLYKRGSVRSLSTYSA	DPFAYPGAGGLYMRGSVRSLSTYSA	6.0	4.0	-	-	4245_17:36718116-36718116 T>A_DPFAYPGAGGLYMRGSVRSLSTYSA	0.0
16:71113803-71113803 C>G	1.0	4326	BREAST	-	-	-	-	HYDIN	ENST00000393550,p.G575R|ENST00000545230,p.G363R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000545230	nonsynonymous SNV	exon8	c.G1087C	p.G363R	PTFHFNVPALHFGDVSFATQELRDP	PTFHFNVPALHFRDVSFATQELRDP	5.0	7.0	-	-	4326_16:71113803-71113803 C>G_PTFHFNVPALHFRDVSFATQELRDP	0.0
3:41275274-41275274 G>T	1.0	4129	NSCLC	-	-	-	1	CTNNB1	uc011azg.1,p.M408I|ENST00000453024,p.M473I|uc003ckp.2,p.M480I|ENST00000349496,p.M480I|uc003ckr.2,p.M480I|ENST00000405570,p.M480I|uc010hia.1,p.M480I|uc003cks.3,p.M83I|NM_001098210,p.M480I|ENST00000396185,p.M480I|uc003ckq.2,p.M480I|uc011azf.1,p.M473I|ENST00000396183,p.M480I|NM_001904,p.M480I|NM_001098209,p.M480I	retained_intron, protein_coding, processed_transcript	uc011azg.1	nonsynonymous SNV	exon9	c.G1224T	p.M408I	LRHLTSRHQEAEMAQNAVRLHYGLP	LRHLTSRHQEAEIAQNAVRLHYGLP	10.0	8.0	-	-	4129_3:41275274-41275274 G>T_LRHLTSRHQEAEIAQNAVRLHYGLP	0.0
17:7256482-7256482 G>A	1.0	4245	COLORECTAL	-	-	-	-	KCTD11	NM_001002914,p.R74Q|ENST00000333751,p.R74Q|uc002gge.4,p.R74Q	protein_coding, processed_transcript	uc002gge.4	nonsynonymous SNV	exon1	c.G221A	p.R74Q	DFYQIRPLLDALRELEASQGTPAPT	DFYQIRPLLDALQELEASQGTPAPT	7.0	9.0	-	-	4245_17:7256482-7256482 G>A_DFYQIRPLLDALQELEASQGTPAPT	0.0
10:94836975-94836975 G>A	1.0	4252	COLORECTAL	-	-	-	-	CYP26A1	ENST00000224356,p.G470R|ENST00000371531,p.G401R|NM_000783,p.G470R|NM_057157,p.G401R|uc001kik.1,p.G401R|uc001kil.2,p.G470R|ENST00000394139,p.G401R	protein_coding	uc001kil.2	nonsynonymous SNV	exon7	c.G1408A	p.G470R	ELARHCDWQLLNGPPTMKTSPTVYP	ELARHCDWQLLNRPPTMKTSPTVYP	5.0	6.0	-	-	4252_10:94836975-94836975 G>A_ELARHCDWQLLNRPPTMKTSPTVYP	0.0
12:25398284-25398284 C>A	1.0	4316	COLORECTAL	-	-	ID=COSM1140133,COSM520;OCCURENCE=24(skin),10(breast),24(small_intestine),17(urinary_tract),2(genital_tract),2(kidney),1(eye),5(liver),1402(pancreas),39(prostate),110(biliary_tract),4060(large_intestine),1(autonomic_ganglia),245(ovary),4(soft_tissue),102(endometrium),13(thyroid),13(peritoneum),878(lung),6(testis),8(cervix),36(haematopoietic_and_lymphoid_tissue),2(pleura),9(gastrointestinal_tract_(site_indeterminate)),1(central_nervous_system),32(stomach),2(thymus),3(upper_aerodigestive_tract),4(oesophagus)	1	KRAS	NM_004985,p.G12V|uc001rgp.1,p.G12V|ENST00000311936,p.G12V|ENST00000556131,p.G12V|NM_033360,p.G12V|ENST00000557334,p.G12V|ENST00000256078,p.G12V|uc001rgq.1,p.G12V	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G35T	p.G12V	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGAVGVGKSALTIQLI	6.0	8.0	-	-	4316_12:25398284-25398284 C>A_MTEYKLVVVGAVGVGKSALTIQLI	0.0
10:44140025-44140025 G>A	1.0	3713	MELANOMA	-	-	-	-	ZNF32	ENST00000374433,p.H99Y|uc001jbb.3,p.H99Y|uc001jbc.3,p.H99Y|NM_006973,p.H99Y|NM_001005368,p.H99Y|ENST00000395797,p.H99Y	protein_coding, processed_transcript	uc001jbc.3	nonsynonymous SNV	exon3	c.C295T	p.H99Y	RQKGSLTLHERIHTGQKPFECTHCG	RQKGSLTLHERIYTGQKPFECTHCG	8.0	9.0	-	-	3713_10:44140025-44140025 G>A_RQKGSLTLHERIYTGQKPFECTHCG	0.0
16:87870183-87870183 T>C	1.0	4335	COLORECTAL	-	-	-	-	SLC7A5	ENST00000565644,p.N138S|uc002fkm.3,p.N404S|NM_003486,p.N404S|ENST00000261622,p.N404S	retained_intron, protein_coding	uc002fkm.3	nonsynonymous SNV	exon8	c.A1211G	p.N404S	DIFSVINFFSFFNWLCVALAIIGMI	DIFSVINFFSFFSWLCVALAIIGMI	9.0	10.0	-	-	4335_16:87870183-87870183 T>C_DIFSVINFFSFFSWLCVALAIIGMI	0.0
4:145039891-145039891 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	GYPA	uc010ior.3,p.L18I|ENST00000512789,p.L18I	retained_intron, protein_coding, nonsense_mediated_decay	uc010ior.3	nonsynonymous SNV	exon2	c.C52A	p.L18I	IFVLLLSGERVQLAHHFSEPEITLI	IFVLLLSGERVQIAHHFSEPEITLI	1.0	9.0	-	-	4258_4:145039891-145039891 G>T_IFVLLLSGERVQIAHHFSEPEITLI	0.0
16:66885432-66885432 G>A	0.0	4252	COLORECTAL	-	-	-	-	CA7	uc002eqi.3,p.G142S|ENST00000394069,p.G86S|uc002eqj.3,p.G86S|NM_005182,p.G142S|ENST00000338437,p.G142S|NM_001014435,p.G86S	protein_coding, nonsense_mediated_decay	uc002eqj.3	nonsynonymous SNV	exon4	c.G256A	p.G86S	YSTFGEAASAPDGLAVVGVFLETGD	YSTFGEAASAPDSLAVVGVFLETGD	4.0	9.0	-	-	4252_16:66885432-66885432 G>A_YSTFGEAASAPDSLAVVGVFLETGD	0.0
6:2765890-2765890 C>A	1.0	4095	COLORECTAL	-	-	-	-	WRNIP1	uc003mua.3,p.L12I|ENST00000380773,p.L12I|NM_020135,p.L12I|uc003mtz.3,p.L12I|NM_130395,p.L12I|ENST00000380771,p.L12I	protein_coding	uc003mua.3	nonsynonymous SNV	exon1	c.C34A	p.L12I	MEVSGPEDDPFLSQLHQVQCPVCQ	MEVSGPEDDPFISQLHQVQCPVCQ	9.0	9.0	-	-	4095_6:2765890-2765890 C>A_MEVSGPEDDPFISQLHQVQCPVCQ	0.0
17:72888801-72888801 C>T	0.0	4110	BILE DUCT	-	-	-	-	FADS6	ENST00000310226,p.R69H|uc002jmd.1,p.R69H	retained_intron, protein_coding	uc002jmd.1	nonsynonymous SNV	exon2	c.G206A	p.R69H	SLFALPAGFLCLRWENALVFASGIT	SLFALPAGFLCLHWENALVFASGIT	2.0	8.0	-	-	4110_17:72888801-72888801 C>T_SLFALPAGFLCLHWENALVFASGIT	0.0
19:51645978-51645978 G>T	0.0	4266	COLORECTAL	-	-	-	-	SIGLEC7	ENST00000601682,p.A118S|ENST00000536156,p.A118S|uc002pvv.1,p.A118S|uc010eor.1,p.A118S|NM_001277201,p.A118S|NM_014385,p.A118S|uc002pvw.1,p.A118S|ENST00000600577,p.A118S|ENST00000317643,p.A118S|NM_016543,p.A118S|ENST00000305628,p.A118S	retained_intron, protein_coding, nonsense_mediated_decay	uc010eor.1	nonsynonymous SNV	exon1	c.G352T	p.A118S	CTLSIRDARMSDAGRYFFRMEKGNI	CTLSIRDARMSDSGRYFFRMEKGNI	5.0	3.0	-	-	4266_19:51645978-51645978 G>T_CTLSIRDARMSDSGRYFFRMEKGNI	0.0
1:156128577-156128577 C>T	0.0	4155	MELANOMA	-	-	-	-	SEMA4A	NM_022367,p.P177L|NM_001193301,p.P177L|uc001fno.3,p.P177L|ENST00000368282,p.P177L|uc001fnn.3,p.P45L|ENST00000438830,p.P144L|ENST00000368285,p.P177L|uc009wrq.3,p.P177L|ENST00000368286,p.P45L|ENST00000435124,p.P177L|ENST00000355014,p.P177L|NM_001193300,p.P177L|uc001fnl.3,p.P177L|ENST00000368284,p.P45L|uc001fnm.3,p.P177L|ENST00000414683,p.P78L|NM_001193302,p.P45L	protein_coding, processed_transcript	uc009wrq.3	nonsynonymous SNV	exon6	c.C530T	p.P177L	SEDKVMEGKGQSPFDPAHKHTAVLV	SEDKVMEGKGQSLFDPAHKHTAVLV	7.0	4.0	-	-	4155_1:156128577-156128577 C>T_SEDKVMEGKGQSLFDPAHKHTAVLV	0.0
1:214170833-214170833 G>A	1.0	2556	MELANOMA	-	-	-	-	PROX1	ENST00000498508,p.E319K|uc001hkg.2,p.E319K|uc001hkh.4,p.E319K|ENST00000366958,p.E319K|ENST00000435016,p.E319K|NM_001270616,p.E319K|ENST00000261454,p.E319K|NM_002763,p.E319K	protein_coding	uc001hkh.4	nonsynonymous SNV	exon2	c.G955A	p.E319K	FIDRARALIREQEMAENKPKREGNN	FIDRARALIREQKMAENKPKREGNN	8.0	1.0	-	-	2556_1:214170833-214170833 G>A_FIDRARALIREQKMAENKPKREGNN	0.0
17:26874328-26874328 C>T	1.0	4000	MELANOMA	-	-	-	-	UNC119	NM_005148,p.S237N|uc002hbk.2,p.S237N|ENST00000484980,p.S142N|ENST00000335765,p.S237N	retained_intron, protein_coding	uc002hbk.2	nonsynonymous SNV	exon5	c.G710A	p.S237N	RLVMHNKADYSYSGTP	RLVMHNKADYSYNGTP	8.0	6.0	-	-	4000_17:26874328-26874328 C>T_RLVMHNKADYSYNGTP	0.0
17:58945948-58945948 C>T	1.0	3713	MELANOMA	-	-	-	-	BCAS3	ENST00000588462,p.P163L|ENST00000390652,p.P163L|NM_017679,p.P163L|ENST00000408905,p.P163L|uc002iyw.4,p.P159L|ENST00000589222,p.P163L|NM_001099432,p.P163L|ENST00000407086,p.P163L|uc002iyv.4,p.P163L|uc002iyu.4,p.P163L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002iyw.4	nonsynonymous SNV	exon8	c.C476T	p.P159L	VCKSIGSSGTSPPYCCVDLYSLRTG	VCKSIGSSGTSPLYCCVDLYSLRTG	8.0	9.0	-	-	3713_17:58945948-58945948 C>T_VCKSIGSSGTSPLYCCVDLYSLRTG	0.0
19:33167719-33167719 G>A	0.0	4240	BREAST	-	-	-	-	RGS9BP	uc002ntp.1,p.E184K|ENST00000334176,p.E184K|NM_207391,p.E184K	protein_coding	uc002ntp.1	nonsynonymous SNV	exon1	c.G550A	p.E184K	RWTVQARQAAGAELLSTVSAGPSSV	RWTVQARQAAGAKLLSTVSAGPSSV	4.0	9.0	-	-	4240_19:33167719-33167719 G>A_RWTVQARQAAGAKLLSTVSAGPSSV	0.0
16:81916938-81916938 G>A	0.0	4301	MELANOMA	-	-	-	-	PLCG2	uc010chg.1,p.E253K|uc002fgt.3,p.E253K|NM_002661,p.E253K|ENST00000359376,p.E253K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010chg.1	nonsynonymous SNV	exon8	c.G757A	p.E253K	VYLHDFQRFLIHEQQEHWAQDLNKV	VYLHDFQRFLIHKQQEHWAQDLNKV	10.0	5.0	-	-	4301_16:81916938-81916938 G>A_VYLHDFQRFLIHKQQEHWAQDLNKV	0.0
2:71205921-71205921 C>G	1.0	4284	COLORECTAL	-	-	-	-	ANKRD53	ENST00000360589,p.T49S|NM_024933,p.T49S|NM_001115116,p.T49S|uc002shk.4,p.T49S|ENST00000272421,p.T49S|uc002shl.4,p.T49S	retained_intron, protein_coding	uc002shl.4	nonsynonymous SNV	exon1	c.C146G	p.T49S	QQANKVSLKATWTDAESKQPSQPLP	QQANKVSLKATWSDAESKQPSQPLP	4.0	9.0	-	-	4284_2:71205921-71205921 C>G_QQANKVSLKATWSDAESKQPSQPLP	0.0
14:57938299-57938299 T>A	0.0	4196	COLORECTAL	-	-	-	-	C14orf105	uc010trl.1,p.K262M|NM_001283056,p.K262M|ENST00000422976,p.K262M	retained_intron, protein_coding, nonsense_mediated_decay	uc010trl.1	nonsynonymous SNV	exon7	c.A785T	p.K262M	SASRVAGITGNSKNTEFLKHQAVNN	SASRVAGITGNSMNTEFLKHQAVNN	5.0	8.0	-	-	4196_14:57938299-57938299 T>A_SASRVAGITGNSMNTEFLKHQAVNN	0.0
2:32673897-32673897 C>T	1.0	3466	MELANOMA	-	-	-	2	BIRC6	ENST00000421745,p.L1507F|NM_016252,p.L1507F|uc010ezu.3,p.L1507F	retained_intron, protein_coding, nonsense_mediated_decay	uc010ezu.3	nonsynonymous SNV	exon22	c.C4519T	p.L1507F	RYGLYSSPFDPVLFDLEMSGSSCKN	RYGLYSSPFDPVFFDLEMSGSSCKN	9.0	1.0	-	-	3466_2:32673897-32673897 C>T_RYGLYSSPFDPVFFDLEMSGSSCKN	0.0
12:78513190-78513190 G>A	1.0	3713	MELANOMA	-	-	-	-	NAV3	uc001syo.3,p.G1072R|ENST00000397909,p.G1072R|ENST00000536525,p.G1072R|ENST00000266692,p.G1072R|NM_001024383,p.G1072R|uc009zsf.3,p.G80R|uc001syp.3,p.G1072R|ENST00000228327,p.G1072R|uc010sub.2,p.G572R|NM_014903,p.G1072R	retained_intron, protein_coding, processed_transcript	uc010sub.2	nonsynonymous SNV	exon7	c.G1714A	p.G572R	TATSSFGFKKPSGVGSSAMITSSGA	TATSSFGFKKPSRVGSSAMITSSGA	4.0	6.0	-	-	3713_12:78513190-78513190 G>A_TATSSFGFKKPSRVGSSAMITSSGA	0.0
17:7012100-7012100 C>G	0.0	4237	NSCLC	-	-	-	-	ASGR2	NM_001201352,p.G78R|uc010clw.2,p.G59R|ENST00000254850,p.G59R|uc002geo.2,p.G78R|NM_080913,p.G59R|uc002geq.3,p.G59R|ENST00000574868,p.G78R	retained_intron, protein_coding, nonsense_mediated_decay	uc010clw.2	nonsynonymous SNV	exon3	c.G175C	p.G59R	FNILLLVVICVTGSQSAQLQAELRS	FNILLLVVICVTRSQSAQLQAELRS	5.0	9.0	-	-	4237_17:7012100-7012100 C>G_FNILLLVVICVTRSQSAQLQAELRS	0.0
3:105258914-105258914 C>T	1.0	3713	MELANOMA	-	-	-	-	ALCAM	uc003dvy.3,p.P276S|NM_001243280,p.P276S|ENST00000472644,p.P276S|NM_001243281,p.P276S|ENST00000306107,p.P276S|NM_001627,p.P276S|ENST00000486979,p.P225S|uc003dvw.2,p.P276S|uc011bhh.1,p.P225S|uc003dvx.3,p.P276S	retained_intron, protein_coding, processed_transcript	uc011bhh.1	nonsynonymous SNV	exon8	c.C673T	p.P225S	DNITLKCLGNGNPPPEEFLFYLPGQ	DNITLKCLGNGNSPPEEFLFYLPGQ	6.0	9.0	-	-	3713_3:105258914-105258914 C>T_DNITLKCLGNGNSPPEEFLFYLPGQ	0.0
6:37619945-37619945 A>C	0.0	4110	BILE DUCT	-	-	-	-	MDGA1	NM_153487,p.L385R|ENST00000297153,p.L385R|ENST00000434837,p.L385R|uc003onu.1,p.L385R|ENST00000505425,p.L385R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003onu.1	nonsynonymous SNV	exon7	c.T1154G	p.L385R	KNGKPARMSKRLLVTRNDPELPAVT	KNGKPARMSKRLRVTRNDPELPAVT	6.0	5.0	-	-	4110_6:37619945-37619945 A>C_KNGKPARMSKRLRVTRNDPELPAVT	0.0
X:101139223-101139223 G>T	0.0	4316	COLORECTAL	-	-	-	-	ZMAT1	uc011mrm.2,p.F221L|NM_001282401,p.F221L|NM_001011657,p.F392L|uc011mrl.2,p.F392L|uc004eim.3,p.F221L|ENST00000540921,p.F392L|ENST00000372782,p.F392L|uc004ein.3,p.F221L|NM_001282400,p.F221L|ENST00000458570,p.F221L	protein_coding, processed_transcript	uc011mrm.2	nonsynonymous SNV	exon9	c.C663A	p.F221L	WLPTHSKRTYDSFQDELEDYIKVQK	WLPTHSKRTYDSLQDELEDYIKVQK	3.0	10.0	-	-	4316_X:101139223-101139223 G>T_WLPTHSKRTYDSLQDELEDYIKVQK	0.0
X:44918698-44918698 T>G	1.0	4177	PANCREATIC	-	-	-	1	KDM6A	uc011mlb.2,p.I394S|ENST00000382899,p.I394S|NM_001291416,p.I394S|uc011mld.2,p.I60S	protein_coding, processed_transcript	uc011mld.2	nonsynonymous SNV	exon2	c.T179G	p.I60S	KSCSNTSALAARIKYLQACKPHHPN	KSCSNTSALAARSKYLQACKPHHPN	7.0	10.0	-	-	4177_X:44918698-44918698 T>G_KSCSNTSALAARSKYLQACKPHHPN	0.0
3:155206530-155206530 G>A	0.0	3775	CERVICAL	-	-	ID=COSM1420168,COSM1420169;OCCURENCE=1(large_intestine)	-	PLCH1	ENST00000494598,p.R808W|NM_001130961,p.R808W|uc021xgf.1,p.R790W|NM_014996,p.R790W|NM_001130960,p.R808W|ENST00000460012,p.R790W|ENST00000340059,p.R808W|ENST00000334686,p.R790W|ENST00000414191,p.R790W|uc021xge.1,p.R808W|ENST00000447496,p.R808W|uc021xgd.1,p.R808W	retained_intron, protein_coding	uc021xgf.1	nonsynonymous SNV	exon19	c.C2368T	p.R790W	TFTVHMPEIALVRFLVWDHDPIGRD	TFTVHMPEIALVWFLVWDHDPIGRD	3.0	6.0	-	-	3775_3:155206530-155206530 G>A_TFTVHMPEIALVWFLVWDHDPIGRD	0.0
14:34269794-34269794 G>A	0.0	4284	COLORECTAL	-	-	-	-	NPAS3	ENST00000551634,p.G735R|ENST00000357798,p.G748R|ENST00000356141,p.G761R|NM_022123,p.G729R|uc001wru.3,p.G761R|ENST00000551492,p.G766R|NM_001164749,p.G761R|ENST00000548645,p.G731R|uc001wrv.3,p.G731R|ENST00000346562,p.G729R|NM_173159,p.G748R|NM_001165893,p.G731R|uc001wrt.3,p.G729R|uc001wrs.3,p.G748R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wrv.3	nonsynonymous SNV	exon11	c.G2191A	p.G731R	PPLSASPRDKHPGNGGGGGGGGGGA	PPLSASPRDKHPRNGGGGGGGGGGA	4.0	7.0	-	-	4284_14:34269794-34269794 G>A_PPLSASPRDKHPRNGGGGGGGGGGA	0.0
12:110765611-110765611 A>G	1.0	4136	BREAST	-	-	-	-	ATP2A2	ENST00000395494,p.Y268C|ENST00000308664,p.Y295C|NM_170665,p.Y295C|uc021rdt.1,p.Y143C|uc001tql.4,p.Y295C|uc001tqk.4,p.Y295C|ENST00000539276,p.Y295C|NM_001681,p.Y295C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021rdt.1	nonsynonymous SNV	exon4	c.A428G	p.Y143C	VHGGSWIRGAIYYFKIAVALAVAAI	VHGGSWIRGAIYCFKIAVALAVAAI	9.0	8.0	-	-	4136_12:110765611-110765611 A>G_VHGGSWIRGAIYCFKIAVALAVAAI	0.0
5:60194173-60194173 A>T	1.0	4345	COLORECTAL	-	-	-	-	ERCC8	NM_001290285,p.L105H|uc011cqp.1,p.L105H|uc003jsl.3,p.L200H|ENST00000543101,p.L105H|ENST00000265038,p.L258H|uc003jsm.3,p.L258H|ENST00000426742,p.L200H|NM_000082,p.L258H|NM_001007233,p.L200H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cqp.1	nonsynonymous SNV	exon8	c.T314A	p.L105H	GKVNGLCFTSDGLHLLTVGTDNRMR	GKVNGLCFTSDGHHLLTVGTDNRMR	6.0	6.0	-	-	4345_5:60194173-60194173 A>T_GKVNGLCFTSDGHHLLTVGTDNRMR	0.0
6:78172849-78172849 A>G	0.0	4213	COLORECTAL	-	-	-	-	HTR1B	uc003pil.1,p.L91P|ENST00000369947,p.L91P|NM_000863,p.L91P	protein_coding	uc003pil.1	nonsynonymous SNV	exon1	c.T272C	p.L91P	KLHTPANYLIASLAVTDLLVSILVM	KLHTPANYLIASPAVTDLLVSILVM	5.0	4.0	-	-	4213_6:78172849-78172849 A>G_KLHTPANYLIASPAVTDLLVSILVM	0.0
6:7571685-7571685 A>G	1.0	4180	BREAST	-	-	-	-	DSP	uc021yle.1,p.I591V|uc003mxp.1,p.I591V|ENST00000379802,p.I591V|NM_004415,p.I591V|uc003mxq.1,p.I591V|NM_001008844,p.I591V|ENST00000418664,p.I591V	retained_intron, protein_coding	uc021yle.1	nonsynonymous SNV	exon14	c.A1771G	p.I591V	TIADLELHYQEFIRNSQGSEMFGDD	TIADLELHYQEFVRNSQGSEMFGDD	10.0	8.0	-	-	4180_6:7571685-7571685 A>G_TIADLELHYQEFVRNSQGSEMFGDD	0.0
X:49019235-49019235 C>T	0.0	3775	CERVICAL	-	-	-	-	MAGIX	NM_001099681,p.P3L|NM_024859,p.P3L|NM_001099682,p.P3L	protein_coding, processed_transcript	NM_024859	nonsynonymous SNV	exon1	c.C8T	p.P3L	MEPRTGDAADPRGSR	MELRTGDAADPRGSR	4.0	5.0	-	-	3775_X:49019235-49019235 C>T_MELRTGDAADPRGSR	0.0
19:17323022-17323022 C>T	1.0	3466	MELANOMA	-	-	-	-	MYO9B	ENST00000594824,p.P2126L|uc010eak.3,p.P2126L|NM_004145,p.P2126L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010eak.3	nonsynonymous SNV	exon40	c.C6377T	p.P2126L	PGADLPVQGALEPLEEDGQPPGAKR	PGADLPVQGALELLEEDGQPPGAKR	10.0	8.0	-	-	3466_19:17323022-17323022 C>T_PGADLPVQGALELLEEDGQPPGAKR	0.0
14:103434693-103434693 T>G	1.0	4298	COLORECTAL	-	-	-	-	CDC42BPB	NM_006035,p.H748P|uc001ymi.1,p.H748P|ENST00000361246,p.H748P	retained_intron, protein_coding	uc001ymi.1	nonsynonymous SNV	exon16	c.A2243C	p.H748P	LKDKLEKSKRERHNEMEEAVGTIKD	LKDKLEKSKRERPNEMEEAVGTIKD	9.0	3.0	-	-	4298_14:103434693-103434693 T>G_LKDKLEKSKRERPNEMEEAVGTIKD	0.0
6:97246395-97246395 G>A	0.0	4287	COLORECTAL	-	-	ID=COSM1208730;OCCURENCE=1(large_intestine),1(breast)	-	GPR63	uc003pou.3,p.R405C|uc010kcl.3,p.R405C|NM_001143957,p.R405C|uc021zcy.1,p.R405C|ENST00000417980,p.R405C|ENST00000229955,p.R405C|NM_030784,p.R405C	protein_coding	uc021zcy.1	nonsynonymous SNV	exon1	c.C1213T	p.R405C	LPQLPGHTKRRIRPSAVYVCGEHRT	LPQLPGHTKRRICPSAVYVCGEHRT	3.0	9.0	-	-	4287_6:97246395-97246395 G>A_LPQLPGHTKRRICPSAVYVCGEHRT	0.0
9:130167784-130167784 C>G	0.0	3775	CERVICAL	-	-	-	-	SLC2A8	NM_001271712,p.I249M|ENST00000373371,p.I412M|uc031tfc.1,p.I249M|ENST00000451404,p.I249M|uc004bqu.4,p.I412M|NM_014580,p.I412M|ENST00000373352,p.I149M|uc031tfd.1,p.I149M|ENST00000430147,p.I251M	protein_coding, processed_transcript	uc031tfd.1	nonsynonymous SNV	exon6	c.C447G	p.I149M	IFPLHVKGVATGICVLTNWLMAFLV	IFPLHVKGVATGMCVLTNWLMAFLV	7.0	7.0	-	-	3775_9:130167784-130167784 C>G_IFPLHVKGVATGMCVLTNWLMAFLV	0.0
7:93516672-93516672 G>C	0.0	4278	COLORECTAL	-	-	-	-	TFPI2	ENST00000222543,p.P178A|NM_006528,p.P178A|uc003una.2,p.P167A|NM_001271003,p.P167A|uc003umy.2,p.P178A	retained_intron, protein_coding	uc003una.2	nonsynonymous SNV	exon4	c.C499G	p.P167A	LCSANVTRYYFNPRYRTCDAFTYTG	LCSANVTRYYFNARYRTCDAFTYTG	5.0	2.0	-	-	4278_7:93516672-93516672 G>C_LCSANVTRYYFNARYRTCDAFTYTG	0.0
20:31887744-31887744 T>A	0.0	4259	COLORECTAL	-	-	-	-	BPIFB1	ENST00000253354,p.L234H|uc031rst.1,p.L65H|uc002wyw.1,p.L234H|NM_033197,p.L234H	protein_coding, processed_transcript	uc031rst.1	nonsynonymous SNV	exon3	c.T194A	p.L65H	PISLSIDRLEFDLLYPAIKGDTIQL	PISLSIDRLEFDHLYPAIKGDTIQL	2.0	3.0	-	-	4259_20:31887744-31887744 T>A_PISLSIDRLEFDHLYPAIKGDTIQL	0.0
2:210742691-210742691 G>A	0.0	4238	COLORECTAL	-	-	-	-	UNC80	NM_182587,p.R1282Q|ENST00000439458,p.R1287Q|uc021vvx.1,p.R1282Q|uc010zjc.1,p.R1287Q|ENST00000272845,p.R1282Q|uc002vdk.2,p.R448Q|NM_032504,p.R1287Q	retained_intron, protein_coding, processed_transcript	uc021vvx.1	nonsynonymous SNV	exon24	c.G3845A	p.R1282Q	KLFYQWGDAIGVRLNELCHGESESP	KLFYQWGDAIGVQLNELCHGESESP	1.0	6.0	-	-	4238_2:210742691-210742691 G>A_KLFYQWGDAIGVQLNELCHGESESP	0.0
10:33017818-33017818 G>A	0.0	4235	COLORECTAL	-	-	ID=COSM3774493,COSM3774492;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	CCDC7	uc001iwm.1,p.R174H|uc001iwn.4,p.R198H|NM_024688,p.R198H|uc001iwl.1,p.R206H|ENST00000375028,p.R174H|ENST00000375030,p.R206H|ENST00000302316,p.R198H|ENST00000375025,p.R198H	protein_coding, processed_transcript, nonsense_mediated_decay	uc001iwn.4	nonsynonymous SNV	exon9	c.G593A	p.R198H	KKITPGRERRNTRIVVPNENVISVH	KKITPGRERRNTHIVVPNENVISVH	3.0	8.0	-	-	4235_10:33017818-33017818 G>A_KKITPGRERRNTHIVVPNENVISVH	0.0
9:34521585-34521585 G>A	1.0	3713	MELANOMA	-	-	-	-	ENHO	uc003zun.1,p.R37C|NM_198573,p.R37C|ENST00000399775,p.R37C|uc022bgf.1,p.R37C	protein_coding	uc022bgf.1	nonsynonymous SNV	exon1	c.C109T	p.R37C	LLWVILCWACHSRSADVDSLSESSP	LLWVILCWACHSCSADVDSLSESSP	4.0	8.0	-	-	3713_9:34521585-34521585 G>A_LLWVILCWACHSCSADVDSLSESSP	0.0
13:33017202-33017202 C>A	1.0	4275	COLORECTAL	-	-	-	-	N4BP2L2	uc001uug.2,p.R374M|ENST00000357505,p.R476M|ENST00000504114,p.R476M|uc010abd.1,p.R404M|uc001uuh.2,p.R322M|ENST00000399396,p.R491M|uc010tdz.1,p.R476M|NM_033111,p.R491M|uc010abe.1,p.R491M|NM_001278432,p.R476M	retained_intron, protein_coding, processed_transcript	uc010tdz.1	nonsynonymous SNV	exon7	c.G1427T	p.R476M	LESTKNKKRRKKRIFNLVPNFDLLG	LESTKNKKRRKKMIFNLVPNFDLLG	9.0	3.0	-	-	4275_13:33017202-33017202 C>A_LESTKNKKRRKKMIFNLVPNFDLLG	0.0
7:6066495-6066495 C>A	1.0	4345	COLORECTAL	-	-	-	-	EIF2AK1	ENST00000199389,p.G543V|uc003spq.3,p.G542V|uc003spp.3,p.G543V|ENST00000536084,p.G419V|NM_001134335,p.G542V|NM_014413,p.G543V|uc011jwm.1,p.G419V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011jwm.1	nonsynonymous SNV	exon13	c.G1256T	p.G419V	MERAEVLTGLRTGQLPESLRKRCPV	MERAEVLTGLRTVQLPESLRKRCPV	10.0	4.0	-	-	4345_7:6066495-6066495 C>A_MERAEVLTGLRTVQLPESLRKRCPV	0.0
2:53955854-53955854 G>A	1.0	3466	MELANOMA	-	-	-	-	ASB3,GPR75-ASB3	uc021vhl.1,p.S127L|uc002rxh.2,p.S127L|NM_145863,p.S127L|ENST00000406687,p.S127L|NM_016115,p.S200L|ENST00000394717,p.S127L|uc002rxg.2,p.S200L|ENST00000352846,p.S238L|ENST00000406625,p.S235L|uc002rxi.4,p.S238L|NM_001164165,p.S238L|ENST00000263634,p.S200L|NM_001201965,p.S127L	 processed_transcript,retained_intron, protein_coding	uc021vhl.1	nonsynonymous SNV	exon4	c.C380T	p.S127L	QYGKLESLSILISSGANVNCQALDK	QYGKLESLSILILSGANVNCQALDK	7.0	7.0	-	-	3466_2:53955854-53955854 G>A_QYGKLESLSILILSGANVNCQALDK	0.0
7:31378078-31378078 C>T	0.0	3903	MELANOMA	-	-	-	-	NEUROD6	uc003tch.4,p.G269R|ENST00000297142,p.G269R|uc022abi.1,p.G269R|NM_022728,p.G269R	protein_coding	uc022abi.1	nonsynonymous SNV	exon1	c.G805A	p.G269R	EGPLSPPPINYNGIFSLKQEETLDY	EGPLSPPPINYNRIFSLKQEETLDY	1.0	10.0	-	-	3903_7:31378078-31378078 C>T_EGPLSPPPINYNRIFSLKQEETLDY	0.0
19:39002982-39002982 C>T	0.0	4186	BREAST	-	-	-	-	RYR1	ENST00000355481,p.R3111W|NM_001042723,p.R3111W|uc002oiu.3,p.R3111W|ENST00000359596,p.R3111W|uc010xuf.1,p.R31W|NM_000540,p.R3111W|ENST00000360985,p.R3111W|uc002oit.3,p.R3111W	retained_intron, protein_coding, nonsense_mediated_decay	uc010xuf.1	nonsynonymous SNV	exon2	c.C91T	p.R31W	ASEDIEKMVENLRLGKVSQARTQVK	ASEDIEKMVENLWLGKVSQARTQVK	1.0	9.0	-	-	4186_19:39002982-39002982 C>T_ASEDIEKMVENLWLGKVSQARTQVK	0.0
18:56414805-56414805 C>T	1.0	3713	MELANOMA	-	-	-	1	MALT1	ENST00000345724,p.P725S|ENST00000348428,p.P736S|NM_006785,p.P736S|uc002lhm.1,p.P736S|NM_173844,p.P725S|uc002lhn.1,p.P725S	retained_intron, protein_coding	uc002lhn.1	nonsynonymous SNV	exon16	c.C2173T	p.P725S	KTCFQTCLMSNGPYQSSAATSGGAG	KTCFQTCLMSNGSYQSSAATSGGAG	6.0	5.0	-	-	3713_18:56414805-56414805 C>T_KTCFQTCLMSNGSYQSSAATSGGAG	0.0
6:31624294-31624294 G>C	1.0	4240	BREAST	-	-	-	-	APOM	NM_019101,p.A54P|ENST00000375916,p.A54P|uc003nvl.3,p.A54P	protein_coding	uc003nvl.3	nonsynonymous SNV	exon2	c.G160C	p.A54P	VHLGQWYFIAGAAPTKEELATFDPV	VHLGQWYFIAGAPPTKEELATFDPV	8.0	9.0	-	-	4240_6:31624294-31624294 G>C_VHLGQWYFIAGAPPTKEELATFDPV	0.0
14:76088503-76088503 A>G	1.0	4129	NSCLC	-	-	-	-	FLVCR2	NM_017791,p.S251G|uc001xrs.2,p.S251G|uc010tvd.1,p.S46G|ENST00000539311,p.S46G|NM_001195283,p.S46G|ENST00000238667,p.S251G	retained_intron, protein_coding, processed_transcript	uc010tvd.1	nonsynonymous SNV	exon2	c.A136G	p.S46G	NIEDRDELAYHISIMFYIIGGVATL	NIEDRDELAYHIGIMFYIIGGVATL	8.0	8.0	-	-	4129_14:76088503-76088503 A>G_NIEDRDELAYHIGIMFYIIGGVATL	0.0
17:17801968-17801968 G>A	1.0	2369	MELANOMA	-	-	ID=COSM1720744,COSM1720743;OCCURENCE=2(NS)	-	TOM1L2	uc010vwy.2,p.A53V|NM_001288789,p.A53V|ENST00000379504,p.A53V|uc010vxb.2,p.A53V|ENST00000395739,p.A53V|ENST00000542206,p.A53V|ENST00000579586,p.A20V|ENST00000535933,p.A53V|uc010vxa.2,p.A53V|NM_001082968,p.A53V|uc002grz.4,p.A53V|ENST00000540946,p.A53V|NM_001288788,p.A53V|uc010cpr.3,p.A53V|ENST00000581396,p.A53V|NM_001288787,p.A53V|NM_001288786,p.A53V|uc010vwz.2,p.A53V|uc002gry.4,p.A53V|ENST00000318094,p.A53V|NM_001033551,p.A53V	retained_intron, protein_coding, processed_transcript	uc010vxb.2	nonsynonymous SNV	exon3	c.C158T	p.A53V	NETEEGPKDAIRALKKRLNGNRNYR	NETEEGPKDAIRVLKKRLNGNRNYR	7.0	9.0	-	-	2369_17:17801968-17801968 G>A_NETEEGPKDAIRVLKKRLNGNRNYR	0.0
5:93820600-93820600 A>C	0.0	4266	COLORECTAL	-	-	-	-	KIAA0825	ENST00000513200,p.S336A|NM_001145678,p.S336A|ENST00000312498,p.S336A|ENST00000427991,p.S336A|uc011cuk.2,p.S336A	retained_intron, protein_coding, processed_transcript	uc011cuk.2	nonsynonymous SNV	exon6	c.T1006G	p.S336A	VTTECPQKGRNFSLPLDKVEFLSQL	VTTECPQKGRNFALPLDKVEFLSQL	4.0	5.0	-	-	4266_5:93820600-93820600 A>C_VTTECPQKGRNFALPLDKVEFLSQL	0.0
10:27822678-27822678 A>G	1.0	4037	NSCLC	-	-	ID=COSM1222906;OCCURENCE=1(large_intestine)	-	RAB18	NM_021252,p.R92G|NM_001256415,p.R68G|NM_001256411,p.R92G|uc001itw.4,p.R121G|uc001itv.4,p.R92G|uc031ptn.1,p.R68G|uc010qdq.3,p.R92G|ENST00000356940,p.R92G|NM_001256410,p.R121G	protein_coding, processed_transcript	uc031ptn.1	nonsynonymous SNV	exon4	c.A202G	p.R68G	GAQGVILVYDVTRRDTFVKLDNWLN	GAQGVILVYDVTGRDTFVKLDNWLN	10.0	7.0	-	-	4037_10:27822678-27822678 A>G_GAQGVILVYDVTGRDTFVKLDNWLN	0.0
1:32745698-32745698 A>C	0.0	4238	COLORECTAL	-	-	-	1	LCK	ENST00000373564,p.K412T|NM_001042771,p.K405T|uc001bux.3,p.K405T|NM_005356,p.K405T|ENST00000336890,p.K405T|ENST00000333070,p.K435T|uc001bva.3,p.K412T|uc010ohc.1,p.K449T|uc001buy.3,p.K405T|uc001buz.3,p.K435T	retained_intron, protein_coding	uc010ohc.1	nonsynonymous SNV	exon11	c.A1346C	p.K449T	EYTAREGAKFPIKWTAPEAINYGTF	EYTAREGAKFPITWTAPEAINYGTF	4.0	8.0	-	-	4238_1:32745698-32745698 A>C_EYTAREGAKFPITWTAPEAINYGTF	0.0
2:151343801-151343801 G>T	1.0	3903	MELANOMA	-	-	-	-	RND3	NM_005168,p.A44D|ENST00000263895,p.A44D|ENST00000439275,p.A44D|NM_001254738,p.A44D|uc002txg.3,p.A44D|ENST00000454202,p.A44D|uc010zbv.2,p.A44D|ENST00000375734,p.A44D|uc002txe.3,p.A44D	retained_intron, protein_coding, processed_transcript	uc010zbv.2	nonsynonymous SNV	exon2	c.C131A	p.A44D	SQCGKTALLHVFAKDCFPENYVPTV	SQCGKTALLHVFDKDCFPENYVPTV	10.0	2.0	-	-	3903_2:151343801-151343801 G>T_SQCGKTALLHVFDKDCFPENYVPTV	0.0
12:112481593-112481593 G>C	1.0	4287	COLORECTAL	-	-	-	-	NAA25	ENST00000261745,p.L696V|uc009zwa.2,p.L696V|uc001ttm.3,p.L696V|NM_024953,p.L696V|uc009zvz.2,p.L668V	retained_intron, protein_coding, nonsense_mediated_decay	uc009zwa.2	nonsynonymous SNV	exon18	c.C2086G	p.L696V	TLWLRIRSLTLRLISGLPSLNHPVE	TLWLRIRSLTLRVISGLPSLNHPVE	8.0	2.0	-	-	4287_12:112481593-112481593 G>C_TLWLRIRSLTLRVISGLPSLNHPVE	0.0
5:140057599-140057599 T>A	1.0	4259	COLORECTAL	-	-	-	-	HARS	ENST00000431330,p.D61V|uc011czp.3,p.D61V|NM_001289093,p.D61V	retained_intron, protein_coding, nonsense_mediated_decay	uc011czp.3	nonsynonymous SNV	exon3	c.A182T	p.D61V	ESKQKFVLKTPKDFDIAGNFDPMIP	ESKQKFVLKTPKVFDIAGNFDPMIP	10.0	6.0	-	-	4259_5:140057599-140057599 T>A_ESKQKFVLKTPKVFDIAGNFDPMIP	0.0
2:190557080-190557080 T>G	0.0	4189	MELANOMA	-	-	-	-	ANKAR	ENST00000520309,p.V380G|ENST00000431575,p.V309G|ENST00000438402,p.V380G|ENST00000441800,p.V144G|uc002uqv.1,p.V380G|uc002uqw.2,p.V380G|ENST00000313581,p.V380G|ENST00000433782,p.V309G|ENST00000281412,p.V144G|NM_144708,p.V380G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002uqw.2	nonsynonymous SNV	exon4	c.T1139G	p.V380G	QNFHYKENQYFHVHGGIEFDISTPS	QNFHYKENQYFHGHGGIEFDISTPS	4.0	4.0	-	-	4189_2:190557080-190557080 T>G_QNFHYKENQYFHGHGGIEFDISTPS	0.0
5:137528272-137528272 G>A	1.0	2591	MELANOMA	-	-	-	-	CDC23	uc003lcl.3,p.R363W|NM_004661,p.R363W|ENST00000394886,p.R363W	retained_intron, protein_coding, nonsense_mediated_decay	uc003lcl.3	nonsynonymous SNV	exon10	c.C1087T	p.R363W	ALYFQRALKLNPRYLGAWTLMGHEY	ALYFQRALKLNPWYLGAWTLMGHEY	6.0	10.0	-	-	2591_5:137528272-137528272 G>A_ALYFQRALKLNPWYLGAWTLMGHEY	0.0
11:50003895-50003895 G>T	0.0	4196	COLORECTAL	-	-	-	-	OR4C12	NM_001005270,p.T48N|ENST00000335238,p.T48N|uc010ria.2,p.T48N	protein_coding	uc010ria.2	nonsynonymous SNV	exon1	c.C143A	p.T48N	TLSGNLLIVVTITTSQALSSPMYFF	TLSGNLLIVVTINTSQALSSPMYFF	3.0	9.0	-	-	4196_11:50003895-50003895 G>T_TLSGNLLIVVTINTSQALSSPMYFF	0.0
7:11452339-11452339 T>C	0.0	4238	COLORECTAL	-	-	-	-	THSD7A	uc021zzo.1,p.E1209G|ENST00000423059,p.E1209G|NM_015204,p.E1209G	retained_intron, protein_coding, processed_transcript	uc021zzo.1	nonsynonymous SNV	exon18	c.A3626G	p.E1209G	PADEGRSCPNAVEKEPCNLNKNCYH	PADEGRSCPNAVGKEPCNLNKNCYH	2.0	7.0	-	-	4238_7:11452339-11452339 T>C_PADEGRSCPNAVGKEPCNLNKNCYH	0.0
19:17337816-17337820 CGCCC>-	0.0	4316	COLORECTAL	-	-	-	-	OCEL1	ENST00000215061,p.A87fs|ENST00000601529,p.A87fs|uc002nfp.3,p.A87fs|ENST00000597836,p.A31fs|NM_024578,p.A87fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002nfp.3	frameshift deletion	exon3	c.260_264del	p.A87fs	HPPGPGPPLQGLAPRGLKTSAPRPP	HPPGPGPPLQGLARPQNQRPPPSVPAPAGTPQGKDQEDCV	4.0	5.0	-	-	4316_19:17337816-17337820 CGCCC>-_HPPGPGPPLQGLARPQNQRPPPSVPAPAGTPQGKDQEDCV	0.0
X:9622268-9622268 C>G	0.0	4246	COLORECTAL	-	-	-	-	TBL1X	ENST00000217964,p.H39Q|NM_005647,p.H39Q|NM_001139466,p.H39Q|uc010ndq.3,p.H39Q|uc004csr.3,p.H39Q|ENST00000452824,p.H39Q|ENST00000441088,p.H39Q|ENST00000407597,p.H39Q	protein_coding, processed_transcript	uc010ndq.3	nonsynonymous SNV	exon5	c.C117G	p.H39Q	HFQRLRGREGGSHFINTSSPRGEAK	HFQRLRGREGGSQFINTSSPRGEAK	5.0	7.0	-	-	4246_X:9622268-9622268 C>G_HFQRLRGREGGSQFINTSSPRGEAK	0.0
6:102069900-102069900 T>G	1.0	3716	MELANOMA	-	-	-	-	GRIK2	ENST00000369134,p.I15M|uc003pqn.3,p.I64M|NM_021956,p.I64M|ENST00000318991,p.I64M|uc010kcw.3,p.I64M|NM_175768,p.I64M|ENST00000369138,p.I64M|uc003pqo.4,p.I64M|ENST00000369137,p.I64M|ENST00000358361,p.I64M|NM_001166247,p.I64M|ENST00000421544,p.I64M|uc021zdj.1,p.I64M|ENST00000413795,p.I64M|uc003pqp.4,p.I64M|uc021zdk.1,p.I64M	retained_intron, protein_coding	uc021zdk.1	nonsynonymous SNV	exon2	c.T192G	p.I64M	AEELAFRFAVNTINRNRTLLPNTTL	AEELAFRFAVNTMNRNRTLLPNTTL	6.0	9.0	-	-	3716_6:102069900-102069900 T>G_AEELAFRFAVNTMNRNRTLLPNTTL	0.0
5:140594228-140594228 A>G	1.0	4160	COLORECTAL	-	-	-	-	PCDHB13	uc003lja.1,p.Y178C|ENST00000341948,p.Y178C|NM_018933,p.Y178C	protein_coding	uc003lja.1	nonsynonymous SNV	exon1	c.A533G	p.Y178C	NNIENYIISPNSYFRVLTRKRSDGR	NNIENYIISPNSCFRVLTRKRSDGR	4.0	9.0	-	-	4160_5:140594228-140594228 A>G_NNIENYIISPNSCFRVLTRKRSDGR	0.0
1:145361463-145361463 C>A	1.0	4252	COLORECTAL	-	rs77064224	-	-	NBPF25P	ENST00000342960,p.Q3123K|uc021oul.2,p.Q3123K	protein_coding, processed_transcript	uc021oul.2	nonsynonymous SNV	exon75	c.C9367A	p.Q3123K	GLAVDMDEIEKYQEVEEDQDPSCPR	GLAVDMDEIEKYKEVEEDQDPSCPR	8.0	5.0	-	-	4252_1:145361463-145361463 C>A_GLAVDMDEIEKYKEVEEDQDPSCPR	0.0
4:2883633-2883633 T>G	1.0	3678	MELANOMA	-	-	-	-	ADD1	uc003gft.3,p.C68W|ENST00000446856,p.C68W|ENST00000355842,p.C68W|ENST00000398125,p.C68W|ENST00000511797,p.C68W|NM_001286645,p.C68W|ENST00000503455,p.C68W|NM_001119,p.C68W|uc003gfs.3,p.C68W|ENST00000513328,p.C68W|uc010ico.1,p.C68W|NM_176801,p.C68W|NM_014190,p.C68W|ENST00000264758,p.C68W|uc003gfr.3,p.C68W|ENST00000398123,p.C68W|uc003gfp.3,p.C68W|uc003gfo.3,p.C68W|NM_014189,p.C68W|uc003gfq.3,p.C68W|ENST00000398129,p.C68W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ico.1	nonsynonymous SNV	exon3	c.T204G	p.C68W	KRVSMILQSPAFCEELESMIQEQFK	KRVSMILQSPAFWEELESMIQEQFK	10.0	1.0	-	-	3678_4:2883633-2883633 T>G_KRVSMILQSPAFWEELESMIQEQFK	0.0
1:115220128-115220128 C>T	0.0	4298	COLORECTAL	-	-	-	-	AMPD1	uc001eff.2,p.G440D|NM_000036,p.G444D|uc001efe.2,p.G444D|ENST00000369538,p.G440D|ENST00000520113,p.G444D|ENST00000353928,p.G411D|NM_001172626,p.G440D	protein_coding, nonsense_mediated_decay	uc001eff.2	nonsynonymous SNV	exon9	c.G1319A	p.G440D	NGEYFATIIKEVGADLVEAKYQHAE	NGEYFATIIKEVDADLVEAKYQHAE	2.0	8.0	-	-	4298_1:115220128-115220128 C>T_NGEYFATIIKEVDADLVEAKYQHAE	0.0
6:110768129-110768129 C>G	0.0	4129	NSCLC	-	-	-	-	SLC22A16	ENST00000330550,p.A166P|ENST00000451557,p.A117P|ENST00000439654,p.A200P|ENST00000437378,p.A157P|NM_033125,p.A200P|ENST00000424139,p.A157P|ENST00000368919,p.A200P|uc003pue.3,p.A181P|ENST00000434949,p.A30P|uc003puf.3,p.A200P	protein_coding, processed_transcript	uc003puf.3	nonsynonymous SNV	exon3	c.G598C	p.A200P	TSSSMFLFGIAAAFAVDYYTFMAAR	TSSSMFLFGIAAPFAVDYYTFMAAR	2.0	10.0	-	-	4129_6:110768129-110768129 C>G_TSSSMFLFGIAAPFAVDYYTFMAAR	0.0
21:41505787-41505787 C>G	0.0	3775	CERVICAL	-	-	ID=COSM1307811;OCCURENCE=1(urinary_tract)	-	DSCAM	NM_001271534,p.E1186Q|ENST00000400454,p.E1186Q|ENST00000404019,p.E938Q|uc031rvr.1,p.E1186Q|uc002yyq.1,p.E1186Q|NM_001389,p.E1186Q	protein_coding	uc031rvr.1	nonsynonymous SNV	exon19	c.G3556C	p.E1186Q	GVRSEQIFTRTKEDVPGPPAGVKAA	GVRSEQIFTRTKQDVPGPPAGVKAA	1.0	8.0	-	-	3775_21:41505787-41505787 C>G_GVRSEQIFTRTKQDVPGPPAGVKAA	0.0
6:38690710-38690710 C>T	0.0	4213	COLORECTAL	0.0014	-	-	-	DNAH8	ENST00000327475,p.P30L|NM_001206927,p.P42L|ENST00000373278,p.P42L|uc021yzh.1,p.P42L|ENST00000449981,p.P42L	protein_coding	uc021yzh.1	nonsynonymous SNV	exon2	c.C125T	p.P42L	EEEAPRPPTVEAPAEDGFSPSAEDA	EEEAPRPPTVEALAEDGFSPSAEDA	3.0	8.0	-	-	4213_6:38690710-38690710 C>T_EEEAPRPPTVEALAEDGFSPSAEDA	0.0
2:88118106-88118106 C>T	0.0	4240	BREAST	-	-	-	-	RGPD1,RGPD2	NM_001078170,p.E37K|ENST00000420840,p.E29K|NM_001024457,p.E29K|ENST00000398146,p.E37K|uc010fhc.2,p.E37K|uc021vkn.1,p.E29K	protein_coding, processed_transcript	uc021vkn.1	nonsynonymous SNV	exon2	c.G85A	p.E29K	KLRGFYFAKLYYEAKEYDLAKKYVC	KLRGFYFAKLYYKAKEYDLAKKYVC	5.0	8.0	-	-	4240_2:88118106-88118106 C>T_KLRGFYFAKLYYKAKEYDLAKKYVC	0.0
8:2057287-2057287 T>G	0.0	4335	COLORECTAL	-	-	-	-	MYOM2	NM_003970,p.F1049V|uc011kwi.2,p.F474V|uc003wpx.4,p.F1049V|ENST00000523438,p.F474V|ENST00000262113,p.F1049V	retained_intron, protein_coding, processed_transcript	uc011kwi.2	nonsynonymous SNV	exon12	c.T1420G	p.F474V	QAEHLSPDASYRFIINDREVSDSEI	QAEHLSPDASYRVIINDREVSDSEI	5.0	3.0	-	-	4335_8:2057287-2057287 T>G_QAEHLSPDASYRVIINDREVSDSEI	0.0
19:36278433-36278433 C>T	1.0	4317	COLORECTAL	0.0005	-	-	-	ARHGAP33	uc002obt.2,p.S853L|ENST00000378944,p.S853L|NM_001172630,p.S853L	retained_intron, protein_coding, processed_transcript	uc002obt.2	nonsynonymous SNV	exon20	c.C2558T	p.S853L	GSLLRSQRPMGTSRRGLRGPAQVPT	GSLLRSQRPMGTLRRGLRGPAQVPT	9.0	7.0	-	-	4317_19:36278433-36278433 C>T_GSLLRSQRPMGTLRRGLRGPAQVPT	0.0
19:57290811-57290811 A>G	0.0	4213	COLORECTAL	-	-	-	-	ZIM2	NM_001146326,p.S226P|ENST00000391708,p.S226P|uc010ygr.1,p.S22P|ENST00000221722,p.S226P|NM_015363,p.S226P|ENST00000601070,p.S226P|uc002qnq.2,p.S226P|NM_001146327,p.S226P|ENST00000593711,p.S226P|uc010ygq.1,p.S22P|ENST00000599935,p.S226P|uc010etp.2,p.S226P|uc002qnr.2,p.S226P|uc010ygs.1,p.S226P	retained_intron, protein_coding, nonsense_mediated_decay	uc010ygs.1	nonsynonymous SNV	exon10	c.T676C	p.S226P	SLGHQFSKPDIISRLEEEESYAMET	SLGHQFSKPDIIPRLEEEESYAMET	3.0	4.0	-	-	4213_19:57290811-57290811 A>G_SLGHQFSKPDIIPRLEEEESYAMET	0.0
2:86260846-86260846 C>T	1.0	4317	COLORECTAL	-	-	-	-	POLR1A	uc010ytb.2,p.V733I|ENST00000263857,p.V1367I|uc002sqs.3,p.V1367I|NM_015425,p.V1367I|ENST00000409681,p.V1367I|uc002sqt.1,p.V390I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ytb.2	nonsynonymous SNV	exon15	c.G2197A	p.V733I	KKKNNKASAFRNVNTRRATQRDLDN	KKKNNKASAFRNINTRRATQRDLDN	8.0	8.0	-	-	4317_2:86260846-86260846 C>T_KKKNNKASAFRNINTRRATQRDLDN	0.0
8:145057613-145057613 A>G	1.0	4046	OVARIAN	-	-	-	-	PARP10	uc003zal.4,p.F715S|ENST00000525773,p.F727S|uc003zam.2,p.F706S|ENST00000527262,p.F715S|ENST00000524918,p.F706S|uc011lku.2,p.F727S|NM_032789,p.F715S|uc003zak.4,p.F412S|ENST00000313028,p.F715S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lku.2	nonsynonymous SNV	exon7	c.T2180C	p.F727S	TDGKAQLVVHSAFEQDVEELDRALR	TDGKAQLVVHSASEQDVEELDRALR	10.0	5.0	-	-	4046_8:145057613-145057613 A>G_TDGKAQLVVHSASEQDVEELDRALR	0.0
12:18435341-18435341 T>G	0.0	4278	COLORECTAL	-	-	-	-	PIK3C2G	ENST00000535651,p.F109C|uc001rdt.3,p.F109C|NM_001288772,p.F109C|ENST00000266497,p.F109C|NM_004570,p.F109C|ENST00000546003,p.F109C|uc010sib.2,p.F109C|ENST00000538779,p.F109C|ENST00000433979,p.F109C	protein_coding, processed_transcript, nonsense_mediated_decay	uc010sib.2	nonsynonymous SNV	exon1	c.T326G	p.F109C	SWHQVSKAPAIGFSPSVLPKPQNTN	SWHQVSKAPAIGCSPSVLPKPQNTN	3.0	1.0	-	-	4278_12:18435341-18435341 T>G_SWHQVSKAPAIGCSPSVLPKPQNTN	0.0
5:79855094-79855094 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	ANKRD34B	uc003kgw.3,p.V249I|NM_001004441,p.V249I|ENST00000338682,p.V249I|uc010jam.3,p.V249I|uc010jan.3,p.V249I|uc021yax.1,p.V249I	protein_coding	uc021yax.1	nonsynonymous SNV	exon1	c.G745A	p.V249I	PKGPKLPHAPPWVKSPPLLMHQNRV	PKGPKLPHAPPWIKSPPLLMHQNRV	1.0	6.0	-	-	4258_5:79855094-79855094 C>T_PKGPKLPHAPPWIKSPPLLMHQNRV	0.0
12:89993046-89993046 T>C	1.0	4160	COLORECTAL	-	-	-	-	ATP2B1	uc001tbf.3,p.K701E|ENST00000348959,p.K1031E	retained_intron, protein_coding	uc001tbf.3	nonsynonymous SNV	exon12	c.A2101G	p.K701E	VQLISTIPTSRLKFLKEAGHGTQKE	VQLISTIPTSRLEFLKEAGHGTQKE	9.0	5.0	-	-	4160_12:89993046-89993046 T>C_VQLISTIPTSRLEFLKEAGHGTQKE	0.0
8:144649541-144649541 ->C	0.0	4326	BREAST	-	-	-	-	MROH6	ENST00000398882,p.G676fs|NM_001100878,p.G676fs|uc010mff.3,p.G676fs	retained_intron, protein_coding, processed_transcript	uc010mff.3	frameshift insertion	exon14	c.2027dupG	p.G676fs	SAQQVAMLARARGCPRGPRLLRIAP	SAQQVAMLARARGLPPRAPPSPHRPAPRPAPTSLRRQPLPAPERRGPLGLLRTPPSL	5.0	10.0	-	 translated beyond stop codon reached end of cDNA PR	4326_8:144649541-144649541 ->C_SAQQVAMLARARGLPPRAPPSPHRPAPRPAPTSLRRQPLPAPERRGPLGLLRTPPSL	0.0
3:30691871-30691871 ->A	1.0	4281	COLORECTAL	-	-	ID=COSM300123;OCCURENCE=1(large_intestine),1(pancreas)	1	TGFBR2	NM_001024847,p.E150fs|ENST00000359013,p.E150fs|uc003ceo.3,p.E125fs|ENST00000295754,p.E125fs|uc003cen.3,p.E150fs|NM_003242,p.E125fs	protein_coding	uc003ceo.3	frameshift insertion	exon3	c.374dupA	p.E125fs	LEDAASPKCIMKEKKKPGETFFMCS	LEDAASPKCIMKEKKKAW	8.0	9.0	-	-	4281_3:30691871-30691871 ->A_LEDAASPKCIMKEKKKAW	0.0
6:152763328-152763328 G>A	0.0	4238	COLORECTAL	0.01	-	-	-	SYNE1	uc003qow.3,p.A592V|ENST00000448038,p.A1304V|ENST00000367255,p.A1297V|ENST00000341594,p.A1363V|ENST00000367248,p.A1287V|NM_033071,p.A1304V|uc003qot.4,p.A1304V|ENST00000423061,p.A1304V|ENST00000413186,p.A1297V|uc010kjb.1,p.A1280V|ENST00000265368,p.A1297V|uc003qox.1,p.A813V|uc003qou.4,p.A1297V|ENST00000367253,p.A1297V|NM_182961,p.A1297V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kjb.1	nonsynonymous SNV	exon29	c.C3839T	p.A1280V	ISAKKRDVQQQIAQAQQGEGGLPDR	ISAKKRDVQQQIVQAQQGEGGLPDR	4.0	10.0	-	-	4238_6:152763328-152763328 G>A_ISAKKRDVQQQIVQAQQGEGGLPDR	0.0
3:122277227-122277227 G>A	1.0	3879	MELANOMA	-	-	-	-	PARP9	ENST00000466126,p.P13S	retained_intron, protein_coding	ENST00000466126	nonsynonymous SNV	exon3	c.C37T	p.P13S	MDFSMKVFAQIFPQWRKGNTEECLP	MDFSMKVFAQIFSQWRKGNTEECLP	6.0	10.0	-	-	3879_3:122277227-122277227 G>A_MDFSMKVFAQIFSQWRKGNTEECLP	0.0
10:86198453-86198453 T>A	1.0	4037	NSCLC	-	-	-	-	CCSER2	NM_018999,p.L685H|ENST00000224756,p.L685H|uc010qmd.1,p.L685H|uc001kdh.1,p.L685H|uc010qme.1,p.L112H|ENST00000372088,p.L685H|NM_001284240,p.L685H|NM_001284243,p.L112H|ENST00000543283,p.L112H|NM_001284242,p.L112H	protein_coding, processed_transcript	uc010qme.1	nonsynonymous SNV	exon3	c.T335A	p.L112H	TAVKTQLLKLKRLLHQHDGSGSLHD	TAVKTQLLKLKRHLHQHDGSGSLHD	9.0	7.0	-	-	4037_10:86198453-86198453 T>A_TAVKTQLLKLKRHLHQHDGSGSLHD	0.0
10:122334784-122334784 G>A	1.0	3879	MELANOMA	-	-	-	-	PPAPDC1A	ENST00000541332,p.R196H|uc010qtd.2,p.R196H	protein_coding, processed_transcript	uc010qtd.2	nonsynonymous SNV	exon6	c.G587A	p.R196H	LPLYCAMMIALSRMCDYKHHWQVGC	LPLYCAMMIALSHMCDYKHHWQVGC	5.0	5.0	-	-	3879_10:122334784-122334784 G>A_LPLYCAMMIALSHMCDYKHHWQVGC	0.0
16:69170647-69170647 G>A	1.0	4134	NSCLC	-	-	-	-	CIRH1A	ENST00000567235,p.E70K|uc002ewr.2,p.E70K|ENST00000563299,p.E81K|NM_032830,p.E70K|ENST00000314423,p.E70K|ENST00000563094,p.E70K|ENST00000352319,p.E70K|ENST00000566227,p.E22K|ENST00000562237,p.E84K|uc002ews.4,p.E70K	retained_intron, protein_coding, processed_transcript	uc002ews.4	nonsynonymous SNV	exon3	c.G208A	p.E70K	HESRATEALCWAEGQRLFSAGLNGE	HESRATEALCWAKGQRLFSAGLNGE	9.0	4.0	-	-	4134_16:69170647-69170647 G>A_HESRATEALCWAKGQRLFSAGLNGE	0.0
5:137610029-137610029 C>G	0.0	4298	COLORECTAL	-	-	-	-	GFRA3	uc003lco.3,p.A29P|ENST00000274721,p.A29P|ENST00000378362,p.A29P|uc003lcn.3,p.A29P|NM_001496,p.A29P	protein_coding	uc003lco.3	nonsynonymous SNV	exon1	c.G85C	p.A29P	LLLLLPPSPLPLAAGDPLPTESRLM	LLLLLPPSPLPLPAGDPLPTESRLM	3.0	9.0	-	-	4298_5:137610029-137610029 C>G_LLLLLPPSPLPLPAGDPLPTESRLM	0.0
16:68225642-68225642 G>A	1.0	3903	MELANOMA	-	-	-	-	NFATC3	uc002evo.2,p.A1024T|uc010vkv.2,p.A545T|uc010vlb.2,p.A545T|uc010vkm.2,p.A545T|ENST00000346183,p.A1024T|uc010vkq.2,p.A545T|uc010vks.2,p.A545T|uc010vky.2,p.A545T|NM_173165,p.A1024T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vlb.2	nonsynonymous SNV	exon9	c.G1633A	p.A545T	IKPEPEDREPNFATIGLQDITLDDV	IKPEPEDREPNFTTIGLQDITLDDV	7.0	7.0	-	-	3903_16:68225642-68225642 G>A_IKPEPEDREPNFTTIGLQDITLDDV	0.0
8:131124397-131124397 A>G	1.0	4252	COLORECTAL	-	-	-	-	ASAP1	uc011liw.2,p.S775P|uc003yta.2,p.S782P|uc003ysz.2,p.S593P|NM_001247996,p.S775P|ENST00000357668,p.S782P|NM_018482,p.S782P|ENST00000518721,p.S782P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011liw.2	nonsynonymous SNV	exon25	c.T2323C	p.S775P	FTNQIFVSTSTDSPTSPTTEAPPLP	FTNQIFVSTSTDPPTSPTTEAPPLP	7.0	1.0	-	-	4252_8:131124397-131124397 A>G_FTNQIFVSTSTDPPTSPTTEAPPLP	0.0
1:16103708-16103708 C>T	0.0	3713	MELANOMA	-	-	-	-	FBLIM1	ENST00000332305,p.P215S|uc001axi.1,p.P215S|ENST00000400773,p.P215S|ENST00000375766,p.P312S|uc001axh.1,p.P215S|NM_001024216,p.P215S|ENST00000375771,p.P312S|uc001axd.1,p.P312S|NM_017556,p.P312S|uc001axe.1,p.P312S	protein_coding, processed_transcript	uc001axi.1	nonsynonymous SNV	exon4	c.C643T	p.P215S	APVCSICENPIIPRDGKDAFKIECM	APVCSICENPIISRDGKDAFKIECM	4.0	1.0	-	-	3713_1:16103708-16103708 C>T_APVCSICENPIISRDGKDAFKIECM	0.0
8:68145099-68145099 ->CAA	0.0	4298	COLORECTAL	-	-	-	-	ARFGEF1	NM_006421,p.A1124delinsVA|uc003xxn.2,p.A107delinsVA|ENST00000262215,p.A1124delinsVA|ENST00000520381,p.A578delinsVA|uc003xxo.2,p.A1124delinsVA|uc003xxl.1,p.A578delinsVA	retained_intron, protein_coding, processed_transcript	uc003xxo.2	nonframeshift insertion	exon23	c.3370_3371insTTG	p.A1124delinsVA	SIGETSSQSVVVAVDRIFTGSTRLD	SIGETSSQSVVVVAVDRIFTGSTRL	8.0	1.0	-	-	4298_8:68145099-68145099 ->CAA_SIGETSSQSVVVVAVDRIFTGSTRL	0.0
1:201980333-201980334 CT>-	1.0	4278	COLORECTAL	-	-	-	2	ELF3	uc001gxg.4,p.D23fs|ENST00000446188,p.D23fs|ENST00000367283,p.D23fs|NM_004433,p.D23fs|uc001gxh.4,p.D23fs|ENST00000367284,p.D23fs|uc001gxi.4,p.D23fs|NM_001114309,p.D23fs|ENST00000359651,p.D23fs	protein_coding, processed_transcript	uc001gxi.4	frameshift deletion	exon2	c.69_70del	p.D23fs	FSNYFSAMYSSEDSTLASVPPAATF	FSNYFSAMYSSEDHPGLCSPCCHLWGR	10.0	5.0	-	-	4278_1:201980333-201980334 CT>-_FSNYFSAMYSSEDHPGLCSPCCHLWGR	0.0
7:154785460-154785460 G>A	1.0	3466	MELANOMA	-	-	-	-	PAXIP1	ENST00000457196,p.S79F|uc022aqg.1,p.S79F|ENST00000404141,p.S79F|NM_007349,p.S79F|ENST00000397192,p.S79F|uc022aqf.1,p.S79F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022aqg.1	nonsynonymous SNV	exon3	c.C236T	p.S79F	DLPVVKPSWVILSVQCGTLLPVNGF	DLPVVKPSWVILFVQCGTLLPVNGF	6.0	9.0	-	-	3466_7:154785460-154785460 G>A_DLPVVKPSWVILFVQCGTLLPVNGF	0.0
10:43280965-43280965 C>T	1.0	3713	MELANOMA	-	-	-	-	BMS1	NM_014753,p.P71L|ENST00000374518,p.P71L|uc001jaj.3,p.P71L	protein_coding	uc001jaj.3	nonsynonymous SNV	exon3	c.C212T	p.P71L	RTQDLKTKKHHIPVVDRTPLEPPPI	RTQDLKTKKHHILVVDRTPLEPPPI	5.0	6.0	-	-	3713_10:43280965-43280965 C>T_RTQDLKTKKHHILVVDRTPLEPPPI	0.0
20:35414899-35414899 G>A	1.0	4000	MELANOMA	-	-	-	-	SOGA1	NM_080627,p.P1659S|ENST00000357779,p.P1421S|uc021wcx.1,p.P1659S|ENST00000237536,p.P1659S|ENST00000456801,p.P1262S	retained_intron, protein_coding, nonsense_mediated_decay	uc021wcx.1	nonsynonymous SNV	exon15	c.C4975T	p.P1659S	ESSWGGEERALPPSE	ESSWGGEERALPSSE	7.0	1.0	-	-	4000_20:35414899-35414899 G>A_ESSWGGEERALPSSE	0.0
14:92150223-92150223 T>G	0.0	4298	COLORECTAL	-	-	-	-	CATSPERB	ENST00000256343,p.E310A|uc001xzs.1,p.E310A|NM_024764,p.E310A	retained_intron, protein_coding, nonsense_mediated_decay	uc001xzs.1	nonsynonymous SNV	exon11	c.A929C	p.E310A	YNERCFANREHFEVDYVTVTFERNR	YNERCFANREHFAVDYVTVTFERNR	3.0	2.0	-	-	4298_14:92150223-92150223 T>G_YNERCFANREHFAVDYVTVTFERNR	0.0
5:178552078-178552078 G>A	0.0	4266	COLORECTAL	-	-	ID=COSM1244358;OCCURENCE=1(oesophagus)	-	ADAMTS2	uc003mjw.3,p.R952C|NM_014244,p.R952C|ENST00000251582,p.R952C	retained_intron, protein_coding	uc003mjw.3	nonsynonymous SNV	exon19	c.C2854T	p.R952C	VRCIQPLHDNTTRSVHAKHCNDARP	VRCIQPLHDNTTCSVHAKHCNDARP	6.0	2.0	-	-	4266_5:178552078-178552078 G>A_VRCIQPLHDNTTCSVHAKHCNDARP	0.0
3:97591349-97591349 C>A	0.0	4345	COLORECTAL	-	-	-	-	CRYBG3	NM_153605,p.F437L|ENST00000419587,p.F437L|uc021xbn.2,p.F437L	protein_coding	uc021xbn.2	nonsynonymous SNV	exon4	c.C1311A	p.F437L	ELVEPQGPAISDFSCSKSDGSDTTE	ELVEPQGPAISDLSCSKSDGSDTTE	4.0	6.0	-	-	4345_3:97591349-97591349 C>A_ELVEPQGPAISDLSCSKSDGSDTTE	0.0
X:35993912-35993912 G>A	0.0	3998	MELANOMA	-	-	-	-	CXorf22	uc004ddj.3,p.M865I|NM_152632,p.M865I|ENST00000297866,p.M865I	protein_coding, nonsense_mediated_decay	uc004ddj.3	nonsynonymous SNV	exon15	c.G2595A	p.M865I	SNELVLRPRGFFMKTCFRGTVRLYN	SNELVLRPRGFFIKTCFRGTVRLYN	1.0	10.0	-	-	3998_X:35993912-35993912 G>A_SNELVLRPRGFFIKTCFRGTVRLYN	0.0
2:71205921-71205921 C>G	1.0	4284	COLORECTAL	-	-	-	-	ANKRD53	ENST00000457410,p.T49S|ENST00000441349,p.T49S	retained_intron, protein_coding	ENST00000457410	nonsynonymous SNV	exon1	c.C146G	p.T49S	QQANKVSLKATWTDAESKQPSPSKE	QQANKVSLKATWSDAESKQPSPSKE	4.0	9.0	-	-	4284_2:71205921-71205921 C>G_QQANKVSLKATWSDAESKQPSPSKE	0.0
3:71021817-71021817 C>T	1.0	4317	COLORECTAL	-	-	ID=COSM268496;OCCURENCE=1(large_intestine)	1	FOXP1	uc003doo.3,p.R513H|uc003dom.3,p.R438H|NM_001244808,p.R513H|NM_001244815,p.R516H|uc003doi.3,p.R414H|uc003dol.3,p.R514H|ENST00000475937,p.R514H|NM_001244812,p.R438H|ENST00000498215,p.R514H|uc003dok.3,p.R440H|ENST00000491238,p.R516H|uc021xan.1,p.R514H|uc003doj.3,p.R516H|uc003dor.1,p.R291H|NM_001244816,p.R514H|NM_001244813,p.R414H|ENST00000497355,p.R410H|NM_032682,p.R514H|ENST00000493089,p.R513H|NM_001244814,p.R514H|ENST00000318789,p.R514H|uc003dop.3,p.R514H|ENST00000327590,p.R514H|ENST00000484350,p.R438H	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xan.1	nonsynonymous SNV	exon17	c.G1541A	p.R514H	FRRNAATWKNAVRHNLSLHKCFVRV	FRRNAATWKNAVHHNLSLHKCFVRV	10.0	9.0	-	-	4317_3:71021817-71021817 C>T_FRRNAATWKNAVHHNLSLHKCFVRV	0.0
10:71973243-71973243 C>T	1.0	4186	BREAST	-	-	-	-	PPA1	uc001jqv.1,p.D163N|ENST00000373232,p.D163N|NM_021129,p.D163N	protein_coding, processed_transcript	uc001jqv.1	nonsynonymous SNV	exon6	c.G487A	p.D163N	ETDWKVIAINVDDPDAANYNDINDV	ETDWKVIAINVDNPDAANYNDINDV	10.0	2.0	-	-	4186_10:71973243-71973243 C>T_ETDWKVIAINVDNPDAANYNDINDV	0.0
4:2065844-2065844 G>A	0.0	4259	COLORECTAL	-	-	-	-	NAT8L	NM_178557,p.R300H|ENST00000331662,p.R132H|ENST00000423729,p.R300H|uc003geq.2,p.R300H	protein_coding	uc003geq.2	nonsynonymous SNV	exon3	c.G899A	p.R300H	FQVRYHRYRLQLREE	FQVRYHRYRLQLHEE	5.0	10.0	-	-	4259_4:2065844-2065844 G>A_FQVRYHRYRLQLHEE	0.0
17:6594177-6594177 G>A	0.0	2591	MELANOMA	-	-	-	-	SLC13A5	NM_177550,p.S453F|ENST00000573648,p.S453F|uc010clq.3,p.S410F|NM_001284509,p.S436F|ENST00000572727,p.S156F|ENST00000381074,p.S410F|NM_001143838,p.S453F|NM_001284510,p.S410F|uc002gdj.3,p.S453F|ENST00000293800,p.S436F|uc010vtf.2,p.S453F|ENST00000433363,p.S453F|uc002gdk.3,p.S436F	retained_intron, protein_coding, nonsense_mediated_decay	uc010vtf.2	nonsynonymous SNV	exon10	c.C1358T	p.S453F	HAVPPAAITLILSLLVAVFTECTSN	HAVPPAAITLILFLLVAVFTECTSN	1.0	2.0	-	-	2591_17:6594177-6594177 G>A_HAVPPAAITLILFLLVAVFTECTSN	0.0
3:46727055-46727055 T>G	1.0	4317	COLORECTAL	-	-	-	-	ALS2CL	ENST00000434140,p.E249A|ENST00000431015,p.E249A|ENST00000318962,p.E249A|uc003cqa.2,p.E249A|ENST00000450172,p.E249A|NM_147129,p.E249A|ENST00000415953,p.E249A|uc003cqb.2,p.E249A|NM_001190707,p.E249A	retained_intron, protein_coding, nonsense_mediated_decay	uc003cqb.2	nonsynonymous SNV	exon7	c.A746C	p.E249A	QDVPVTVAPLRAERVLLFDDALVLL	QDVPVTVAPLRAARVLLFDDALVLL	9.0	2.0	-	-	4317_3:46727055-46727055 T>G_QDVPVTVAPLRAARVLLFDDALVLL	0.0
8:61777720-61777720 T>G	1.0	4234	NSCLC	-	-	-	-	CHD7	NM_017780,p.I2741S|uc022aux.1,p.I692S|ENST00000423902,p.I2741S|ENST00000524602,p.I692S|uc003xue.3,p.I2741S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc022aux.1	nonsynonymous SNV	exon5	c.T2075G	p.I692S	AAAAAAVASTSGINPLLVNSLFAGM	AAAAAAVASTSGSNPLLVNSLFAGM	9.0	7.0	-	-	4234_8:61777720-61777720 T>G_AAAAAAVASTSGSNPLLVNSLFAGM	0.0
12:32490653-32490653 G>T	1.0	4110	BILE DUCT	-	-	-	-	BICD1	uc001rkw.1,p.A107S|uc001rku.3,p.A825S|ENST00000281474,p.A825S|NM_001714,p.A825S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001rkw.1	nonsynonymous SNV	exon2	c.G319T	p.A107S	KSKIGSPKVSGEASVTVPTIDTYLL	KSKIGSPKVSGESSVTVPTIDTYLL	5.0	9.0	-	-	4110_12:32490653-32490653 G>T_KSKIGSPKVSGESSVTVPTIDTYLL	0.0
15:86182612-86182612 G>A	1.0	4000	MELANOMA	-	-	ID=COSM1708503,COSM231735;OCCURENCE=2(skin)	-	AKAP13	uc031qtl.1,p.R30Q|NM_001270546,p.R30Q	retained_intron, protein_coding, processed_transcript	uc031qtl.1	nonsynonymous SNV	exon2	c.G89A	p.R30Q	DRTVDVVLLKINRENWCTIEPCPDA	DRTVDVVLLKINQENWCTIEPCPDA	10.0	7.0	-	-	4000_15:86182612-86182612 G>A_DRTVDVVLLKINQENWCTIEPCPDA	0.0
22:26897906-26897906 T>C	1.0	4196	COLORECTAL	-	-	-	-	TFIP11	ENST00000405938,p.K254R|ENST00000407148,p.K254R|NM_012143,p.K254R|uc003act.2,p.K254R|NM_001008697,p.K254R|ENST00000407690,p.K254R|uc003acs.2,p.K254R|ENST00000407431,p.K254R|uc003acr.2,p.K254R	retained_intron, protein_coding, processed_transcript	uc003act.2	nonsynonymous SNV	exon8	c.A761G	p.K254R	TVEELKAKGRISKKLTAPQKELSQV	TVEELKAKGRISRKLTAPQKELSQV	9.0	4.0	-	-	4196_22:26897906-26897906 T>C_TVEELKAKGRISRKLTAPQKELSQV	0.0
17:62029216-62029216 G>-	0.0	4110	BILE DUCT	-	-	-	-	SCN4A	uc002jds.1,p.A807fs|ENST00000578147,p.A807fs|NM_000334,p.A807fs|ENST00000435607,p.A807fs	retained_intron, protein_coding	uc002jds.1	frameshift deletion	exon14	c.2421delC	p.A807fs	NLFLALLLSSFSADSLAASDEDGEM	NLFLALLLSSFSATVWQPRMRMAR	3.0	8.0	-	-	4110_17:62029216-62029216 G>-_NLFLALLLSSFSATVWQPRMRMAR	0.0
2:215274981-215274981 A>T	0.0	3466	MELANOMA	-	-	-	-	SPAG16	ENST00000374309,p.H519L|ENST00000331683,p.H613L|ENST00000451561,p.H237L|uc010zjk.3,p.H519L|uc002ver.4,p.H559L|uc002veq.4,p.H613L|NM_024532,p.H613L	protein_coding, processed_transcript, nonsense_mediated_decay	uc010zjk.3	nonsynonymous SNV	exon15	c.A1556T	p.H519L	GHENEAHTVVFSHDGEILFSGGSDG	GHENEAHTVVFSLDGEILFSGGSDG	5.0	2.0	-	-	3466_2:215274981-215274981 A>T_GHENEAHTVVFSLDGEILFSGGSDG	0.0
17:7942511-7942511 C>A	0.0	4246	COLORECTAL	-	-	-	-	ALOX15B	uc002gjw.3,p.A13D|uc002gjv.3,p.A13D|ENST00000572022,p.A13D|NM_001039130,p.A13D|ENST00000380183,p.A13D|NM_001141,p.A13D|ENST00000573359,p.A13D|uc002gju.3,p.A13D|uc010vun.2,p.A13D|NM_001039131,p.A13D|ENST00000380173,p.A13D	retained_intron, protein_coding	uc010vun.2	nonsynonymous SNV	exon1	c.C38A	p.A13D	MAEFRVRVSTGEAFGAGTWDKVSVS	MAEFRVRVSTGEDFGAGTWDKVSVS	4.0	7.0	-	-	4246_17:7942511-7942511 C>A_MAEFRVRVSTGEDFGAGTWDKVSVS	0.0
3:50102527-50102527 C>T	1.0	3903	MELANOMA	-	-	-	-	RBM6	uc003cye.3,p.P362S|ENST00000443081,p.P752S|ENST00000266022,p.P884S|uc011bdi.2,p.P226S|NM_001167582,p.P362S|uc003cyd.3,p.P362S|ENST00000442092,p.P362S|ENST00000422955,p.P362S|NM_005777,p.P884S|ENST00000539992,p.P226S|uc003cyc.3,p.P884S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bdi.2	nonsynonymous SNV	exon11	c.C676T	p.P226S	APAEDVFKKPLPPTVKKEESPPPPK	APAEDVFKKPLPSTVKKEESPPPPK	9.0	3.0	-	-	3903_3:50102527-50102527 C>T_APAEDVFKKPLPSTVKKEESPPPPK	0.0
1:10207148-10207148 A>T	1.0	4320	COLORECTAL	-	-	-	-	UBE4B	uc021ogc.1,p.D915V|NM_006048,p.D735V|NM_001105562,p.D864V|ENST00000377157,p.D619V|ENST00000253251,p.D735V|uc001aqr.4,p.D735V|uc010oaj.2,p.D319V|ENST00000343090,p.D864V|uc001aqs.4,p.D864V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ogc.1	nonsynonymous SNV	exon20	c.A2744T	p.D915V	QLLLRILDPAYPDITLPLNSDVPKV	QLLLRILDPAYPVITLPLNSDVPKV	7.0	7.0	-	-	4320_1:10207148-10207148 A>T_QLLLRILDPAYPVITLPLNSDVPKV	0.0
1:235505714-235505714 T>G	1.0	4252	COLORECTAL	-	-	-	-	GGPS1	uc031psu.1,p.L177R|ENST00000488594,p.L177R|NM_001037277,p.L177R|ENST00000497327,p.L177R|ENST00000358966,p.L177R|ENST00000282841,p.L177R|uc001hww.3,p.L177R|ENST00000476121,p.L177R|uc001hwv.3,p.L177R|ENST00000471812,p.L177R|ENST00000391855,p.L123R|uc001hwx.3,p.L123R	protein_coding, processed_transcript	uc031psu.1	nonsynonymous SNV	exon4	c.T530G	p.L177R	LFSDYKEDLKPLLNTLGLFFQIRDD	LFSDYKEDLKPLRNTLGLFFQIRDD	9.0	3.0	-	-	4252_1:235505714-235505714 T>G_LFSDYKEDLKPLRNTLGLFFQIRDD	0.0
17:33875518-33875518 G>A	0.0	3998	MELANOMA	0.0005	-	-	-	SLFN14	uc010ctu.1,p.R827C|NM_001129820,p.R827C|ENST00000415846,p.R827C	protein_coding	uc010ctu.1	nonsynonymous SNV	exon4	c.C2479T	p.R827C	IAILCRRGEDRGRYRLALLKAMELI	IAILCRRGEDRGCYRLALLKAMELI	1.0	8.0	-	-	3998_17:33875518-33875518 G>A_IAILCRRGEDRGCYRLALLKAMELI	0.0
13:61987147-61987147 T>G	0.0	4287	COLORECTAL	-	-	-	-	PCDH20	NM_022843,p.K362T|ENST00000409186,p.K362T|uc010thj.2,p.K362T|ENST00000409204,p.K362T|uc001vid.4,p.K362T	protein_coding, processed_transcript	uc010thj.2	nonsynonymous SNV	exon5	c.A1085C	p.K362T	GTNAQITYSYSQKVPQASKDLFHLD	GTNAQITYSYSQTVPQASKDLFHLD	3.0	8.0	-	-	4287_13:61987147-61987147 T>G_GTNAQITYSYSQTVPQASKDLFHLD	0.0
3:178936091-178936091 G>A	1.0	4320	COLORECTAL	-	-	ID=COSM763,COSM125370;OCCURENCE=4(salivary_gland),38(endometrium),4(soft_tissue),28(ovary),1(pituitary),4(kidney),3(pancreas),3(liver),126(urinary_tract),1(biliary_tract),373(large_intestine),1(prostate),365(breast),16(skin),1(small_intestine),41(upper_aerodigestive_tract),8(oesophagus),18(stomach),17(central_nervous_system),21(cervix),7(gastrointestinal_tract_(site_indeterminate)),4(penis),44(lung),7(thyroid)	1	PIK3CA	ENST00000263967,p.E545K|uc003fjk.3,p.E545K|NM_006218,p.E545K	retained_intron, protein_coding	uc003fjk.3	nonsynonymous SNV	exon10	c.G1633A	p.E545K	AISTRDPLSEITEQEKDFLWSHRHY	AISTRDPLSEITKQEKDFLWSHRHY	7.0	8.0	-	-	4320_3:178936091-178936091 G>A_AISTRDPLSEITKQEKDFLWSHRHY	0.0
4:169433274-169433274 C>T	0.0	3713	MELANOMA	-	-	-	-	PALLD	NM_016081,p.P207S|ENST00000333488,p.P84S|ENST00000261509,p.P207S|NM_001166108,p.P207S|ENST00000505667,p.P207S|uc003iru.3,p.P207S|uc011cjx.2,p.P207S|ENST00000508898,p.P186S	retained_intron, protein_coding	uc011cjx.2	nonsynonymous SNV	exon2	c.C619T	p.P207S	GESSSPDSGYLSPKNQPSALLSASA	GESSSPDSGYLSSKNQPSALLSASA	7.0	5.0	-	-	3713_4:169433274-169433274 C>T_GESSSPDSGYLSSKNQPSALLSASA	0.0
16:71509509-71509509 G>A	1.0	3716	MELANOMA	-	-	-	-	ZNF19	uc002fal.1,p.S302F|uc002fak.1,p.S302F|ENST00000565637,p.S272F|ENST00000288177,p.S314F|NM_006961,p.S314F|ENST00000564230,p.S314F|uc010cgc.1,p.S314F|uc002fam.1,p.S314F|ENST00000565100,p.S244F	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010cgc.1	nonsynonymous SNV	exon6	c.C941T	p.S314F	ECNECGKSFGRTSHLSQHQRIHTGE	ECNECGKSFGRTFHLSQHQRIHTGE	3.0	7.0	-	-	3716_16:71509509-71509509 G>A_ECNECGKSFGRTFHLSQHQRIHTGE	0.0
10:102684073-102684073 C>G	0.0	4235	COLORECTAL	-	-	-	-	FAM178A	uc001krt.4,p.P439A|ENST00000370271,p.P439A|NM_018121,p.P439A|uc001kru.1,p.P374A|ENST00000370269,p.P439A|NM_001136123,p.P439A|ENST00000238961,p.P439A|uc001krr.1,p.P439A|uc001krs.3,p.P439A	protein_coding, processed_transcript	uc001kru.1	nonsynonymous SNV	exon3	c.C1120G	p.P374A	QVAGTKETKMQKPHLPLSQEKSAIK	QVAGTKETKMQKAHLPLSQEKSAIK	6.0	5.0	-	-	4235_10:102684073-102684073 C>G_QVAGTKETKMQKAHLPLSQEKSAIK	0.0
14:45478252-45478252 C>T	1.0	3713	MELANOMA	-	-	-	-	FAM179B	ENST00000361577,p.S1014F|NM_015091,p.S1014F|uc001wvw.3,p.S1014F|ENST00000361462,p.S1014F|uc001wvv.3,p.S1014F	retained_intron, protein_coding, nonsense_mediated_decay	uc001wvw.3	nonsynonymous SNV	exon6	c.C3041T	p.S1014F	KLDLTMDSPSLSSSPNINSYSESGV	KLDLTMDSPSLSFSPNINSYSESGV	4.0	9.0	-	-	3713_14:45478252-45478252 C>T_KLDLTMDSPSLSFSPNINSYSESGV	0.0
19:39664385-39664385 C>T	1.0	3466	MELANOMA	-	-	-	-	PAK4	ENST00000602004,p.P163L|ENST00000435673,p.P278L|uc002oko.1,p.P125L|NM_001014834,p.P125L|ENST00000599386,p.P125L|uc002okm.1,p.P125L|uc002okp.1,p.P188L|uc002okn.1,p.P278L|uc002okj.1,p.P278L|uc002okl.1,p.P278L|NM_005884,p.P278L|ENST00000360442,p.P278L|NM_001014835,p.P125L|NM_001014832,p.P278L|ENST00000599470,p.P125L|ENST00000321944,p.P188L|NM_001014831,p.P278L|ENST00000358301,p.P278L|ENST00000593690,p.P278L	retained_intron, protein_coding, processed_transcript	uc002okp.1	nonsynonymous SNV	exon5	c.C563T	p.P188L	ASEPQLAPPACTPAAPAVPGPPGPR	ASEPQLAPPACTLAAPAVPGPPGPR	6.0	1.0	-	-	3466_19:39664385-39664385 C>T_ASEPQLAPPACTLAAPAVPGPPGPR	0.0
7:72922754-72922754 A>C	1.0	4240	BREAST	-	-	-	-	BAZ1B	ENST00000404251,p.M91R|ENST00000339594,p.M91R|NM_032408,p.M91R|uc003tyc.3,p.M91R	retained_intron, protein_coding	uc003tyc.3	nonsynonymous SNV	exon3	c.T272G	p.M91R	EFPAWYEKLVLEMVHHNTASLEKLV	EFPAWYEKLVLERVHHNTASLEKLV	10.0	7.0	-	-	4240_7:72922754-72922754 A>C_EFPAWYEKLVLERVHHNTASLEKLV	0.0
22:36922149-36922149 G>A	1.0	3919	MELANOMA	-	-	-	-	EIF3D	ENST00000402116,p.P7L|ENST00000432675,p.P7L|ENST00000541106,p.P7L|NM_003753,p.P7L|uc003apr.3,p.P7L|ENST00000455547,p.P7L|uc011amt.2,p.P7L|ENST00000216190,p.P7L|ENST00000457241,p.P7L|ENST00000405442,p.P7L	retained_intron, protein_coding, processed_transcript	uc011amt.2	nonsynonymous SNV	exon2	c.C20T	p.P7L	MAKFMTPVIQDNPSGWGPC	MAKFMTLVIQDNPSGWGPC	10.0	6.0	-	-	3919_22:36922149-36922149 G>A_MAKFMTLVIQDNPSGWGPC	0.0
9:131581324-131581324 G>C	1.0	4252	COLORECTAL	-	-	-	-	ENDOG	ENST00000372642,p.V121L|uc004bwc.3,p.V121L|NM_004435,p.V121L	protein_coding	uc004bwc.3	nonsynonymous SNV	exon1	c.G361C	p.V121L	DRRECDFREDDSVHAYHRATNADYR	DRRECDFREDDSLHAYHRATNADYR	9.0	10.0	CD8	-	4252_9:131581324-131581324 G>C_DRRECDFREDDSLHAYHRATNADYR	2.0
19:57646776-57646776 G>A	0.0	4081	COLORECTAL	-	-	-	-	ZIM3	NM_052882,p.T310M|uc002qnz.1,p.T310M|ENST00000269834,p.T310M	protein_coding	uc002qnz.1	nonsynonymous SNV	exon5	c.C929T	p.T310M	KKVHTGQKPFQCTDCGKAFIYKSDL	KKVHTGQKPFQCMDCGKAFIYKSDL	1.0	6.0	-	-	4081_19:57646776-57646776 G>A_KKVHTGQKPFQCMDCGKAFIYKSDL	0.0
9:139366491-139366491 G>T	1.0	2591	MELANOMA	-	-	-	-	SEC16A	uc004chv.4,p.R604S|uc004chx.3,p.R1214S|NM_014866,p.R1214S|ENST00000371706,p.R1036S|uc004chw.3,p.R1214S|ENST00000290037,p.R1036S|ENST00000313050,p.R1214S|ENST00000431893,p.R1036S|NM_001276418,p.R1214S|uc010nbn.3,p.R1214S	protein_coding, processed_transcript	uc010nbn.3	nonsynonymous SNV	exon3	c.C3640A	p.R1214S	YDGAASAYAQNYRYPEPERPSSRAS	YDGAASAYAQNYSYPEPERPSSRAS	8.0	7.0	-	-	2591_9:139366491-139366491 G>T_YDGAASAYAQNYSYPEPERPSSRAS	0.0
7:116772014-116772014 A>C	1.0	4287	COLORECTAL	-	-	-	-	ST7	ENST00000446490,p.E214A|uc003vio.3,p.E214A|ENST00000393443,p.E164A|ENST00000393446,p.E214A|ENST00000422922,p.E168A|ENST00000393444,p.E171A|uc011knl.2,p.E214A|uc003vir.3,p.E162A|ENST00000465133,p.E171A|ENST00000393451,p.E214A|NM_018412,p.E214A|uc003vix.1,p.E50A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011knl.2	nonsynonymous SNV	exon6	c.A641C	p.E214A	RISAAHEALEINECATAYILLAEEE	RISAAHEALEINACATAYILLAEEE	8.0	7.0	-	-	4287_7:116772014-116772014 A>C_RISAAHEALEINACATAYILLAEEE	0.0
8:145051686-145051686 G>A	1.0	3784	MELANOMA	-	-	-	-	PARP10	uc003zal.4,p.P1015L|ENST00000313028,p.P1015L|ENST00000525773,p.P1027L|ENST00000524918,p.P1006L|NM_032789,p.P1015L|uc011lku.2,p.P1027L|uc003zak.4,p.P712L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lku.2	nonsynonymous SNV	exon10	c.C3080T	p.P1027L	TCEHVPRASPDDPSGLPGRSPDT	TCEHVPRASPDDLSGLPGRSPDT	9.0	7.0	-	-	3784_8:145051686-145051686 G>A_TCEHVPRASPDDLSGLPGRSPDT	0.0
1:65874453-65874453 C>A	0.0	3919	MELANOMA	-	-	-	-	DNAJC6	ENST00000263441,p.P804H|NM_014787,p.P817H|NM_001256865,p.P804H|NM_001256864,p.P874H|ENST00000371069,p.P874H|ENST00000395325,p.P817H|uc001dcd.2,p.P817H|uc010opc.2,p.P804H|uc001dce.2,p.P874H	protein_coding, processed_transcript	uc010opc.2	nonsynonymous SNV	exon18	c.C2411A	p.P804H	EMRKEEMAKEMDPEKLKILEWIEGK	EMRKEEMAKEMDHEKLKILEWIEGK	3.0	3.0	-	-	3919_1:65874453-65874453 C>A_EMRKEEMAKEMDHEKLKILEWIEGK	0.0
18:59821839-59821839 C>G	0.0	4240	BREAST	-	-	-	-	PIGN	NM_176787,p.R163T|ENST00000357637,p.R163T|ENST00000585923,p.R163T|ENST00000589098,p.R68T|ENST00000588748,p.R86T|ENST00000591238,p.R86T|ENST00000400334,p.R163T|uc021ulb.1,p.R163T|ENST00000590765,p.R127T|NM_012327,p.R163T|ENST00000589720,p.R163T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ulb.1	nonsynonymous SNV	exon4	c.G488C	p.R163T	GDHVYTYSYDAKREDFGAQDATKLD	GDHVYTYSYDAKTEDFGAQDATKLD	7.0	10.0	-	-	4240_18:59821839-59821839 C>G_GDHVYTYSYDAKTEDFGAQDATKLD	0.0
X:48923315-48923315 G>A	1.0	4196	COLORECTAL	-	-	-	-	CCDC120	uc004dmf.4,p.E299K|NM_033626,p.E299K|NM_001163321,p.E334K|uc010nik.4,p.E299K|NM_001271836,p.E299K|ENST00000603986,p.E334K|ENST00000376396,p.E299K|ENST00000496529,p.E299K|NM_001271835,p.E299K|ENST00000422185,p.E299K|uc011mms.3,p.E287K|NM_001163323,p.E287K|NM_001163322,p.E287K|uc011mmq.3,p.E287K|uc010nil.4,p.E299K|ENST00000536628,p.E287K|ENST00000597275,p.E299K	protein_coding, processed_transcript	uc011mms.3	nonsynonymous SNV	exon9	c.G859A	p.E287K	PTRSLPRSASSFEGRSVPATPVLTR	PTRSLPRSASSFKGRSVPATPVLTR	7.0	10.0	-	-	4196_X:48923315-48923315 G>A_PTRSLPRSASSFKGRSVPATPVLTR	0.0
7:99771488-99771488 C>T	0.0	4110	BILE DUCT	-	-	-	-	GPC2	uc003utv.3,p.G288R|ENST00000292377,p.G288R|NM_152742,p.G288R	retained_intron, protein_coding, processed_transcript	uc003utv.3	nonsynonymous SNV	exon5	c.G862A	p.G288R	CLNVVRGCLSSRGLEPDWGNYLDGL	CLNVVRGCLSSRRLEPDWGNYLDGL	3.0	5.0	-	-	4110_7:99771488-99771488 C>T_CLNVVRGCLSSRRLEPDWGNYLDGL	0.0
2:113984748-113984748 G>A	0.0	4281	COLORECTAL	-	-	-	1	PAX8	ENST00000263334,p.S365L|uc002tjm.3,p.S288L|ENST00000263335,p.S288L|NM_013952,p.S365L|NM_013953,p.S288L|uc010yxu.2,p.S365L|ENST00000348715,p.S365L	retained_intron, protein_coding, nonsense_mediated_decay	uc010yxu.2	nonsynonymous SNV	exon10	c.C1094T	p.S365L	PPADRAAMPPLPSQAWWQEVNTLAM	PPADRAAMPPLPLQAWWQEVNTLAM	4.0	9.0	-	-	4281_2:113984748-113984748 G>A_PPADRAAMPPLPLQAWWQEVNTLAM	0.0
6:46856086-46856086 A>C	0.0	4335	COLORECTAL	-	-	-	-	GPR116	uc003oyr.2,p.I105R|uc003oyp.3,p.I105R|ENST00000283296,p.I105R|ENST00000456426,p.I105R|uc003oyq.3,p.I105R|NM_015234,p.I105R|NM_001098518,p.I105R|ENST00000362015,p.I105R|uc003oyo.3,p.I105R|ENST00000265417,p.I105R	protein_coding, processed_transcript	uc003oyr.2	nonsynonymous SNV	exon4	c.T314G	p.I105R	GNNTDQITDILSINVTTVCRPAGNE	GNNTDQITDILSRNVTTVCRPAGNE	8.0	8.0	-	-	4335_6:46856086-46856086 A>C_GNNTDQITDILSRNVTTVCRPAGNE	0.0
2:29375616-29375616 C>T	1.0	3466	MELANOMA	-	-	-	-	CLIP4	uc002rmu.3,p.P363S|ENST00000401617,p.P256S|uc010ymn.1,p.P345S|ENST00000404424,p.P363S|ENST00000401605,p.P363S|NM_001287528,p.P363S|NM_001287527,p.P363S|ENST00000415891,p.P363S|uc010ezm.1,p.P363S|ENST00000320081,p.P363S|NM_024692,p.P363S|uc002rmv.3,p.P363S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ymn.1	nonsynonymous SNV	exon8	c.C1033T	p.P345S	KAKGRRKNITHTPSTKAAVPLIRSQ	KAKGRRKNITHTSSTKAAVPLIRSQ	8.0	3.0	-	-	3466_2:29375616-29375616 C>T_KAKGRRKNITHTSSTKAAVPLIRSQ	0.0
13:110830206-110830206 C>G	1.0	4234	NSCLC	-	-	-	-	COL4A1	ENST00000375820,p.G900A|NM_001845,p.G900A|uc001vqw.4,p.G900A	protein_coding, processed_transcript	uc001vqw.4	nonsynonymous SNV	exon33	c.G2699C	p.G900A	GQPGSPGPVGAPGLPGEKGDHGFPG	GQPGSPGPVGAPALPGEKGDHGFPG	9.0	5.0	-	-	4234_13:110830206-110830206 C>G_GQPGSPGPVGAPALPGEKGDHGFPG	0.0
20:62608740-62608740 G>C	0.0	3775	CERVICAL	-	-	-	-	SAMD10	ENST00000450107,p.F76L	protein_coding, processed_transcript	ENST00000450107	nonsynonymous SNV	exon3	c.C228G	p.F76L	PASPDSATAHFSFCRTLLEHTVSAE	PASPDSATAHFSLCRTLLEHTVSAE	5.0	4.0	-	-	3775_20:62608740-62608740 G>C_PASPDSATAHFSLCRTLLEHTVSAE	0.0
2:141526817-141526817 C>T	0.0	3795	MELANOMA	-	-	-	1	LRP1B	NM_018557,p.G1908E|ENST00000389484,p.G1908E|uc002tvj.1,p.G1908E	protein_coding, processed_transcript	uc002tvj.1	nonsynonymous SNV	exon35	c.G5723A	p.G1908E	PSDKMDALMPISGTSFAVGIDFHAE	PSDKMDALMPISETSFAVGIDFHAE	1.0	6.0	-	-	3795_2:141526817-141526817 C>T_PSDKMDALMPISETSFAVGIDFHAE	0.0
19:41132916-41132916 C>T	1.0	3784	MELANOMA	-	-	-	-	LTBP4	ENST00000308370,p.P1407L|ENST00000204005,p.P1370L|ENST00000396819,p.P1340L|uc002ool.1,p.P420L|uc002ooj.1,p.P281L|uc002ook.1,p.P542L|uc010xvp.1,p.P168L|ENST00000545697,p.P775L	retained_intron, protein_coding, processed_transcript	uc010xvp.1	nonsynonymous SNV	exon6	c.C503T	p.P168L	DDFEALCNVLRPPAYSPPRPGGFGL	DDFEALCNVLRPLAYSPPRPGGFGL	9.0	2.0	-	-	3784_19:41132916-41132916 C>T_DDFEALCNVLRPLAYSPPRPGGFGL	0.0
1:154247682-154247682 G>A	1.0	4189	MELANOMA	-	-	-	-	HAX1	ENST00000447768,p.S182N	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000447768	nonsynonymous SNV	exon5	c.G545A	p.S182N	FPRRVLARFYSPSPNPISRASL	FPRRVLARFYSPNPNPISRASL	10.0	9.0	-	-	4189_1:154247682-154247682 G>A_FPRRVLARFYSPNPNPISRASL	0.0
4:167983649-167983649 C>T	0.0	4245	COLORECTAL	0.0005	-	-	-	SPOCK3	uc003irj.1,p.D77N|uc011cjq.1,p.D89N|ENST00000502741,p.D80N|ENST00000504953,p.D77N|ENST00000502330,p.D80N|ENST00000421836,p.D29N|NM_001204352,p.D29N|uc011cjp.2,p.D77N|ENST00000515143,p.D41N|uc021xuf.1,p.D80N|ENST00000506886,p.D80N|ENST00000507086,p.D80N|ENST00000511531,p.D80N|ENST00000357154,p.D80N|ENST00000511269,p.D77N|uc011cjs.1,p.D29N|NM_001204356,p.D77N|ENST00000509854,p.D77N|ENST00000512042,p.D80N|ENST00000512648,p.D77N|NM_001204358,p.D77N|ENST00000357545,p.D77N|NM_016950,p.D80N|NM_001040159,p.D77N|ENST00000510741,p.D77N|uc003irk.4,p.D77N|ENST00000506697,p.D80N|uc003iri.1,p.D80N	protein_coding, processed_transcript, nonsense_mediated_decay	uc021xuf.1	nonsynonymous SNV	exon3	c.G238A	p.D80N	DYFRTWSPGKPFDQALDPAKDPCLK	DYFRTWSPGKPFNQALDPAKDPCLK	4.0	8.0	-	-	4245_4:167983649-167983649 C>T_DYFRTWSPGKPFNQALDPAKDPCLK	0.0
20:5283369-5283369 C>T	0.0	4278	COLORECTAL	-	-	-	-	PROKR2	ENST00000546004,p.V158I|uc010zqy.2,p.V158I|uc010zqx.2,p.V158I|uc010zqw.2,p.V158I|ENST00000217270,p.V158I|NM_144773,p.V158I	protein_coding	uc010zqy.2	nonsynonymous SNV	exon3	c.G472A	p.V158I	LLAIAIDRYLAIVHPLKPRMNYQTA	LLAIAIDRYLAIIHPLKPRMNYQTA	4.0	1.0	-	-	4278_20:5283369-5283369 C>T_LLAIAIDRYLAIIHPLKPRMNYQTA	0.0
22:42564721-42564721 G>A	1.0	4317	COLORECTAL	-	-	-	-	TCF20	uc003bcj.1,p.P1941S|NM_005650,p.P1941S|ENST00000359486,p.P1941S	protein_coding	uc003bcj.1	nonsynonymous SNV	exon4	c.C5821T	p.P1941S	CPKHKPPLPCPLPPLQNKTAKGSLS	CPKHKPPLPCPLSPLQNKTAKGSLS	9.0	9.0	-	-	4317_22:42564721-42564721 G>A_CPKHKPPLPCPLSPLQNKTAKGSLS	0.0
9:131743600-131743600 C>T	0.0	4129	NSCLC	-	-	-	-	NUP188	uc004bws.2,p.H483Y|ENST00000372577,p.H483Y|NM_015354,p.H483Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004bws.2	nonsynonymous SNV	exon15	c.C1447T	p.H483Y	MSFYNELYKHKPHDVISHEDGTLWR	MSFYNELYKHKPYDVISHEDGTLWR	7.0	10.0	-	-	4129_9:131743600-131743600 C>T_MSFYNELYKHKPYDVISHEDGTLWR	0.0
2:33783310-33783310 G>T	1.0	4259	COLORECTAL	-	-	-	-	RASGRP3	uc002roy.3,p.D537Y|ENST00000403687,p.D538Y|NM_001139488,p.D538Y|ENST00000407811,p.D537Y|ENST00000402538,p.D538Y|uc010ync.2,p.D538Y|NM_170672,p.D538Y|NM_015376,p.D537Y|uc002rox.3,p.D538Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ync.2	nonsynonymous SNV	exon16	c.G1612T	p.D538Y	KDCGANCHKQCKDLLVLACRRFARA	KDCGANCHKQCKYLLVLACRRFARA	6.0	10.0	-	-	4259_2:33783310-33783310 G>T_KDCGANCHKQCKYLLVLACRRFARA	0.0
12:123200483-123200483 C>T	0.0	4326	BREAST	-	-	-	-	HCAR3	ENST00000528880,p.V268M|NM_006018,p.V268M|uc001ucy.4,p.V268M	protein_coding	uc001ucy.4	nonsynonymous SNV	exon1	c.G802A	p.V268M	WLLHTSGTQNCEVYRSVDLAFFITL	WLLHTSGTQNCEMYRSVDLAFFITL	4.0	4.0	-	-	4326_12:123200483-123200483 C>T_WLLHTSGTQNCEMYRSVDLAFFITL	0.0
9:139734176-139734176 G>A	1.0	4081	COLORECTAL	0.0032	-	-	-	RABL6	ENST00000371675,p.D482N|ENST00000311502,p.D597N|NM_024718,p.D597N|NM_001173988,p.D598N|ENST00000435930,p.D391N|uc004cji.1,p.D597N|uc004cjj.1,p.D598N|uc010nbs.1,p.D482N|uc004cjn.1,p.D391N|ENST00000371663,p.D598N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010nbs.1	nonsynonymous SNV	exon13	c.G1444A	p.D482N	RADDFPVRDDPSDVTDEDEGPAEPP	RADDFPVRDDPSNVTDEDEGPAEPP	10.0	5.0	-	-	4081_9:139734176-139734176 G>A_RADDFPVRDDPSNVTDEDEGPAEPP	0.0
6:43172719-43172719 C>T	1.0	3713	MELANOMA	-	-	-	-	CUL9	uc003ouk.3,p.R1500C|uc003oul.3,p.R1500C|uc010jyk.3,p.R652C|ENST00000354495,p.R1390C|NM_015089,p.R1500C|ENST00000372647,p.R1500C|ENST00000252050,p.R1500C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jyk.3	nonsynonymous SNV	exon22	c.C1954T	p.R652C	LAAAWRAPDFVPRYCKLYEHLQRAG	LAAAWRAPDFVPCYCKLYEHLQRAG	8.0	2.0	-	-	3713_6:43172719-43172719 C>T_LAAAWRAPDFVPCYCKLYEHLQRAG	0.0
6:30863232-30863232 G>A	1.0	4240	BREAST	-	-	ID=COSM252467,COSM252466;OCCURENCE=1(large_intestine),1(ovary)	-	DDR1	NM_013994,p.R522H|ENST00000376575,p.R522H|NM_001297654,p.R522H|ENST00000513240,p.R522H|ENST00000452441,p.R522H|uc003nrv.3,p.R522H|ENST00000324771,p.R522H|ENST00000376568,p.R522H|NM_013993,p.R522H|uc003nrs.3,p.R522H|uc003nrr.3,p.R522H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003nrv.3	nonsynonymous SNV	exon11	c.G1565A	p.R522H	NPAYRLLLATYARPPRGPGPPTPAW	NPAYRLLLATYAHPPRGPGPPTPAW	10.0	5.0	-	-	4240_6:30863232-30863232 G>A_NPAYRLLLATYAHPPRGPGPPTPAW	0.0
4:56759872-56759872 G>T	1.0	3919	MELANOMA	-	-	-	-	EXOC1	uc003hbf.1,p.D627Y|uc003hbg.1,p.D612Y|ENST00000349598,p.D612Y|ENST00000381295,p.D627Y|ENST00000346134,p.D627Y|NM_018261,p.D627Y|uc003hbe.1,p.D627Y|NM_178237,p.D612Y|NM_001024924,p.D627Y	retained_intron, protein_coding	uc003hbg.1	nonsynonymous SNV	exon14	c.G1834T	p.D612Y	KMSHHVWTAQNVDPASFLSTTLGNV	KMSHHVWTAQNVYPASFLSTTLGNV	5.0	3.0	-	-	3919_4:56759872-56759872 G>T_KMSHHVWTAQNVYPASFLSTTLGNV	0.0
19:55493003-55493003 G>A	0.0	3998	MELANOMA	-	-	-	-	NLRP2	ENST00000538819,p.G115E|ENST00000391721,p.G115E|uc010esn.3,p.G115E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010esn.3	nonsynonymous SNV	exon4	c.G344A	p.G115E	RKPLSLAFTETKGNVICLGKEVFKG	RKPLSLAFTETKENVICLGKEVFKG	3.0	9.0	-	-	3998_19:55493003-55493003 G>A_RKPLSLAFTETKENVICLGKEVFKG	0.0
8:119941025-119941025 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1095407,COSM1154943;OCCURENCE=1(endometrium)	-	TNFRSF11B	NM_002546,p.D182N|ENST00000297350,p.D182N|uc003yon.4,p.D182N	retained_intron, protein_coding, nonsense_mediated_decay	uc003yon.4	nonsynonymous SNV	exon3	c.G544A	p.D182N	GLLLTQKGNATHDNICSGNSESTQK	GLLLTQKGNATHNNICSGNSESTQK	3.0	8.0	-	-	3713_8:119941025-119941025 C>T_GLLLTQKGNATHNNICSGNSESTQK	0.0
1:34090130-34090130 C>T	0.0	4081	COLORECTAL	-	-	-	-	CSMD2	uc001bxo.1,p.A745T|NM_001281956,p.A1872T|uc001bxn.1,p.A1832T|NM_052896,p.A1832T|ENST00000373380,p.A745T|ENST00000241312,p.A1832T|uc001bxm.1,p.A1872T|ENST00000373381,p.A1872T	protein_coding, processed_transcript, nonsense_mediated_decay	uc001bxo.1	nonsynonymous SNV	exon14	c.G2233A	p.A745T	LNCVWKIVVPEGAGIQIQVVSFVTE	LNCVWKIVVPEGTGIQIQVVSFVTE	2.0	8.0	-	-	4081_1:34090130-34090130 C>T_LNCVWKIVVPEGTGIQIQVVSFVTE	0.0
3:33339184-33339184 T>C	1.0	4266	COLORECTAL	-	-	-	-	FBXL2	ENST00000421391,p.I11T|uc003cfp.3,p.I11T|NM_012157,p.I11T|ENST00000484457,p.I11T|ENST00000507198,p.I11T|NM_001171713,p.I11T|uc021wuy.1,p.I11T|ENST00000538892,p.I11T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wuy.1	nonsynonymous SNV	exon2	c.T32C	p.I11T	MVFSNNDEGLINKKLPKELLLRI	MVFSNNDEGLTNKKLPKELLLRI	6.0	5.0	-	-	4266_3:33339184-33339184 T>C_MVFSNNDEGLTNKKLPKELLLRI	0.0
1:245530616-245530616 G>C	1.0	4046	OVARIAN	-	-	-	-	KIF26B	uc001ibf.1,p.D316H|NM_018012,p.D316H|uc010pyr.2,p.D116H|uc010pyq.1,p.D316H|ENST00000407071,p.D316H	retained_intron, protein_coding, processed_transcript	uc010pyr.2	nonsynonymous SNV	exon2	c.G346C	p.D116H	LNSVAIQAHQYLDGTWSLSRTNGVT	LNSVAIQAHQYLHGTWSLSRTNGVT	6.0	10.0	-	-	4046_1:245530616-245530616 G>C_LNSVAIQAHQYLHGTWSLSRTNGVT	0.0
9:101980805-101980805 G>A	1.0	3713	MELANOMA	-	-	-	-	ALG2	ENST00000476832,p.P221L|NM_033087,p.P221L|uc004azg.3,p.P128L|ENST00000319033,p.P128L|uc004azf.3,p.P221L	protein_coding, nonsense_mediated_decay	uc004azg.3	nonsynonymous SNV	exon3	c.C383T	p.P128L	DSVVPEKLDDLVPKGKKFLLLSINR	DSVVPEKLDDLVLKGKKFLLLSINR	8.0	4.0	-	-	3713_9:101980805-101980805 G>A_DSVVPEKLDDLVLKGKKFLLLSINR	0.0
8:144886949-144886949 G>A	1.0	3713	MELANOMA	-	-	-	-	SCRIB	NM_015356,p.S933F|uc003yzo.1,p.S933F|uc003yzp.1,p.S933F|ENST00000377533,p.S852F|ENST00000356994,p.S933F|NM_182706,p.S933F|ENST00000320476,p.S933F	retained_intron, protein_coding, processed_transcript	uc003yzp.1	nonsynonymous SNV	exon21	c.C2798T	p.S933F	VDVTEARHDHAVSLLTAASPTIALL	VDVTEARHDHAVFLLTAASPTIALL	9.0	8.0	-	-	3713_8:144886949-144886949 G>A_VDVTEARHDHAVFLLTAASPTIALL	0.0
8:2806856-2806856 C>T	1.0	4000	MELANOMA	-	-	-	-	CSMD1	NM_033225,p.G3456E|ENST00000602557,p.G3457E|uc011kwj.2,p.G2771E|ENST00000542608,p.G3279E|uc022aqr.1,p.G3456E|ENST00000537824,p.G3456E|ENST00000520002,p.G3457E|ENST00000400186,p.G3280E|uc010lrg.3,p.G1348E|ENST00000602723,p.G3280E	retained_intron, protein_coding, processed_transcript	uc022aqr.1	nonsynonymous SNV	exon68	c.G10367A	p.G3456E	ERGGFTFQGDIHGKDFGKFKLERQD	ERGGFTFQGDIHEKDFGKFKLERQD	4.0	10.0	-	-	4000_8:2806856-2806856 C>T_ERGGFTFQGDIHEKDFGKFKLERQD	0.0
X:134427929-134427929 C>A	0.0	3775	CERVICAL	-	-	-	-	ZNF75D	uc022ceq.1,p.E46D|ENST00000370766,p.E46D|uc004eyo.3,p.E46D|ENST00000370764,p.E46D|NM_001185063,p.E46D|NM_007131,p.E46D	protein_coding, processed_transcript	uc022ceq.1	nonsynonymous SNV	exon2	c.G138T	p.E46D	KKYSTKIENLGPESACRHFWSFRYH	KKYSTKIENLGPDSACRHFWSFRYH	7.0	8.0	-	-	3775_X:134427929-134427929 C>A_KKYSTKIENLGPDSACRHFWSFRYH	0.0
7:55272964-55272964 C>T	1.0	3713	MELANOMA	-	-	ID=COSM1451619;OCCURENCE=1(large_intestine)	1	EGFR	ENST00000275493,p.S1096F|ENST00000454757,p.S1043F|uc003tqk.3,p.S1096F|uc022adn.1,p.S1051F|uc011kco.2,p.S1043F|NM_005228,p.S1096F	retained_intron, protein_coding, processed_transcript	uc022adn.1	nonsynonymous SNV	exon27	c.C3152T	p.S1051F	DTFLPVPEYINQSVPKRPAGSVQNP	DTFLPVPEYINQFVPKRPAGSVQNP	2.0	3.0	-	-	3713_7:55272964-55272964 C>T_DTFLPVPEYINQFVPKRPAGSVQNP	0.0
13:113772782-113772782 G>T	0.0	4129	NSCLC	-	-	-	-	F7	uc001vsv.4,p.Q287H|NM_000131,p.Q287H|NM_001267554,p.Q203H|NM_019616,p.Q265H|uc001vsw.4,p.Q265H|ENST00000541084,p.Q218H|ENST00000375581,p.Q287H|ENST00000346342,p.Q265H|uc010tjt.3,p.Q203H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010tjt.3	nonsynonymous SNV	exon6	c.G609T	p.Q203H	EHDGDEQSRRVAQVIIPSTYVPGTT	EHDGDEQSRRVAHVIIPSTYVPGTT	1.0	6.0	-	-	4129_13:113772782-113772782 G>T_EHDGDEQSRRVAHVIIPSTYVPGTT	0.0
4:119951156-119951156 T>A	0.0	4149	OVARIAN	-	-	-	-	SYNPO2	NM_001128934,p.L409Q|ENST00000429713,p.L409Q|uc003icm.4,p.L409Q|ENST00000307142,p.L409Q|ENST00000434046,p.L409Q|uc010inb.3,p.L409Q|uc010ina.3,p.L409Q|NM_001128933,p.L409Q|NM_001286754,p.L378Q|uc010inc.3,p.L337Q|NM_133477,p.L409Q	protein_coding	uc010inc.3	nonsynonymous SNV	exon3	c.T1010A	p.L337Q	FKKRRRRARKYTLVSYGTGELEREA	FKKRRRRARKYTQVSYGTGELEREA	4.0	5.0	-	-	4149_4:119951156-119951156 T>A_FKKRRRRARKYTQVSYGTGELEREA	0.0
1:100715372-100715372 G>A	1.0	4000	MELANOMA	-	-	-	-	DBT	ENST00000370131,p.A2V|uc021oqo.1,p.A2V|uc001dta.3,p.A2V|NM_001918,p.A2V|ENST00000370132,p.A2V	protein_coding	uc021oqo.1	nonsynonymous SNV	exon1	c.C5T	p.A2V	MAAVRMLRTWSRNA	MVAVRMLRTWSRNA	7.0	9.0	CD8	-	4000_1:100715372-100715372 G>A_MVAVRMLRTWSRNA	1.0
16:1270330-1270330 G>A	0.0	4246	COLORECTAL	-	-	-	-	CACNA1H	uc002ckt.3,p.R2127H|ENST00000565831,p.R2127H|uc002ckv.3,p.R822H|uc002cku.3,p.R828H|ENST00000358590,p.R2127H|NM_001005407,p.R2127H|NM_021098,p.R2133H|uc002cks.3,p.R2133H|ENST00000348261,p.R2133H|uc010brj.3,p.R844H	retained_intron, protein_coding	uc010brj.3	nonsynonymous SNV	exon17	c.G2531A	p.R844H	EASPVAGGERDLRRLYSVDAQGFLD	EASPVAGGERDLHRLYSVDAQGFLD	4.0	6.0	-	-	4246_16:1270330-1270330 G>A_EASPVAGGERDLHRLYSVDAQGFLD	0.0
1:35940486-35940486 G>C	1.0	4335	COLORECTAL	-	-	-	-	KIAA0319L	uc001byx.3,p.S312C|ENST00000325722,p.S312C|ENST00000426982,p.S312C|NM_024874,p.S312C|ENST00000478463,p.S312C|ENST00000482929,p.S312C|uc010ohx.1,p.S312C|ENST00000440579,p.S312C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ohx.1	nonsynonymous SNV	exon5	c.C935G	p.S312C	SAPYPVIKELVVSAGESVQITLPKN	SAPYPVIKELVVCAGESVQITLPKN	9.0	5.0	-	-	4335_1:35940486-35940486 G>C_SAPYPVIKELVVCAGESVQITLPKN	0.0
4:65275050-65275050 G>A	0.0	3903	MELANOMA	-	-	-	-	TECRL	uc003hcv.3,p.S7F|NM_001010874,p.S7F|ENST00000381210,p.S7F|uc003hcw.3,p.S7F|ENST00000507440,p.S7F|ENST00000509536,p.S7F	retained_intron, protein_coding, processed_transcript	uc003hcw.3	nonsynonymous SNV	exon1	c.C20T	p.S7F	MFKRHKSLASERKRALLSQ	MFKRHKFLASERKRALLSQ	1.0	9.0	-	-	3903_4:65275050-65275050 G>A_MFKRHKFLASERKRALLSQ	0.0
9:90502089-90502089 G>A	0.0	3903	MELANOMA	-	-	-	-	SPATA31E1	NM_178828,p.G896E|uc004app.4,p.G896E|uc004apo.1,p.G708E|ENST00000325643,p.G896E	protein_coding	uc004app.4	nonsynonymous SNV	exon4	c.G2687A	p.G896E	RVESVPKVPIFLGKRPQNGPGDNRT	RVESVPKVPIFLEKRPQNGPGDNRT	1.0	10.0	-	-	3903_9:90502089-90502089 G>A_RVESVPKVPIFLEKRPQNGPGDNRT	0.0
7:114304422-114304422 T>G	0.0	4081	COLORECTAL	-	-	-	-	FOXP2	NM_001172766,p.L644R|ENST00000393494,p.L645R|ENST00000408937,p.L670R|uc003vha.3,p.L553R|ENST00000393489,p.L553R|uc003vgz.3,p.L670R|uc011kmv.2,p.L644R|ENST00000403559,p.L662R|ENST00000393491,p.L460R|ENST00000393498,p.L624R|ENST00000350908,p.L645R|NM_148898,p.L670R|NM_148900,p.L662R|uc003vhb.3,p.L645R|uc011kmu.2,p.L662R|uc010ljz.2,p.L460R|NM_014491,p.L645R	protein_coding, processed_transcript, nonsense_mediated_decay	uc011kmv.2	nonsynonymous SNV	exon16	c.T1931G	p.L644R	ASSGLLQAVHEDLNGSLDHIDSNGN	ASSGLLQAVHEDRNGSLDHIDSNGN	2.0	2.0	-	-	4081_7:114304422-114304422 T>G_ASSGLLQAVHEDRNGSLDHIDSNGN	0.0
7:6732209-6732209 C>T	1.0	4326	BREAST	-	-	-	-	ZNF12	NM_016265,p.D122N|ENST00000405858,p.D122N|uc003sqt.1,p.D122N	protein_coding, processed_transcript	uc003sqt.1	nonsynonymous SNV	exon5	c.G364A	p.D122N	IEERGNVPGKTFDVETNPVPSRKIA	IEERGNVPGKTFNVETNPVPSRKIA	8.0	9.0	-	-	4326_7:6732209-6732209 C>T_IEERGNVPGKTFNVETNPVPSRKIA	0.0
22:42310266-42310266 C>G	0.0	4240	BREAST	-	-	-	-	SHISA8	uc021wqh.1,p.E136Q|NM_001207020,p.E136Q	protein_coding	uc021wqh.1	nonsynonymous SNV	exon1	c.G406C	p.E136Q	ARDTAAPRDPGRERSHTAVYAVCGV	ARDTAAPRDPGRQRSHTAVYAVCGV	3.0	9.0	-	-	4240_22:42310266-42310266 C>G_ARDTAAPRDPGRQRSHTAVYAVCGV	0.0
11:105789493-105789493 A>C	0.0	4278	COLORECTAL	-	-	-	-	GRIA4	ENST00000530497,p.K442T|NM_001077243,p.K442T|uc001pix.2,p.K442T|ENST00000525187,p.K442T|ENST00000282499,p.K442T|ENST00000393127,p.K442T|NM_000829,p.K442T|uc001piw.2,p.K442T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001pix.2	nonsynonymous SNV	exon11	c.A1325C	p.K442T	YKKNHEMFEGNDKYEGYCVDLASEI	YKKNHEMFEGNDTYEGYCVDLASEI	1.0	9.0	-	-	4278_11:105789493-105789493 A>C_YKKNHEMFEGNDTYEGYCVDLASEI	0.0
10:94228663-94228663 G>A	1.0	4189	MELANOMA	-	-	-	-	IDE	uc001kia.3,p.R765W|ENST00000371581,p.R210W|uc010qnp.2,p.R210W|ENST00000265986,p.R765W|NM_001165946,p.R210W|NM_004969,p.R765W|uc001khz.3,p.R210W	protein_coding, processed_transcript	uc010qnp.2	nonsynonymous SNV	exon9	c.C628T	p.R210W	AHTKPLLPSQLVRYREVQLPDRGWF	AHTKPLLPSQLVWYREVQLPDRGWF	8.0	6.0	-	-	4189_10:94228663-94228663 G>A_AHTKPLLPSQLVWYREVQLPDRGWF	0.0
9:116931565-116931565 C>T	1.0	4237	NSCLC	-	-	-	-	COL27A1	ENST00000451716,p.P524L|NM_032888,p.P577L|ENST00000356083,p.P577L|uc011lxl.2,p.P577L|uc010mvd.2,p.P427L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011lxl.2	nonsynonymous SNV	exon3	c.C1730T	p.P577L	DVPLSDLTTRPSPRQPQPSQQTTPA	DVPLSDLTTRPSLRQPQPSQQTTPA	7.0	3.0	-	-	4237_9:116931565-116931565 C>T_DVPLSDLTTRPSLRQPQPSQQTTPA	0.0
X:20044026-20044026 G>A	1.0	4196	COLORECTAL	-	-	-	-	MAP7D2	uc011mji.2,p.P258L|uc004czr.2,p.P310L|ENST00000379643,p.P351L|NM_001168467,p.P258L|NM_001168465,p.P351L|uc011mjj.2,p.P265L|uc010nfo.2,p.P351L|NM_001168466,p.P265L|ENST00000543767,p.P195L|ENST00000452324,p.P258L|ENST00000379651,p.P310L|NM_152780,p.P310L|ENST00000443379,p.P265L|uc004czq.2,p.P195L	protein_coding, processed_transcript, nonsense_mediated_decay	uc011mjj.2	nonsynonymous SNV	exon7	c.C794T	p.P265L	TKAYPQSPKTTKPPYPGSPVKYRLP	TKAYPQSPKTTKLPYPGSPVKYRLP	8.0	3.0	-	-	4196_X:20044026-20044026 G>A_TKAYPQSPKTTKLPYPGSPVKYRLP	0.0
19:20228764-20228764 A>C	0.0	4316	COLORECTAL	-	-	-	-	ZNF90	NM_007138,p.N134T|ENST00000418063,p.N134T|uc002nor.2,p.N134T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002nor.2	nonsynonymous SNV	exon4	c.A401C	p.N134T	EGKVHKRGYNGLNQCLTATQSKVFQ	EGKVHKRGYNGLTQCLTATQSKVFQ	6.0	3.0	-	-	4316_19:20228764-20228764 A>C_EGKVHKRGYNGLTQCLTATQSKVFQ	0.0
18:59713138-59713138 G>T	1.0	3903	MELANOMA	-	-	-	-	PIGN	NM_012327,p.T916K|ENST00000400334,p.T916K|uc021ulb.1,p.T916K|ENST00000357637,p.T916K|NM_176787,p.T916K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ulb.1	nonsynonymous SNV	exon28	c.C2747A	p.T916K	FLVFLNGLAQLLTTKKLRLCGKPKS	FLVFLNGLAQLLKTKKLRLCGKPKS	6.0	10.0	-	-	3903_18:59713138-59713138 G>T_FLVFLNGLAQLLKTKKLRLCGKPKS	0.0
22:50662684-50662684 C>T	1.0	4320	COLORECTAL	-	-	-	-	TUBGCP6	ENST00000439308,p.R719Q|ENST00000248846,p.R719Q|uc003bkb.1,p.R719Q|uc010har.1,p.R719Q|uc003bkd.1,p.R73Q|NM_020461,p.R719Q	retained_intron, protein_coding, processed_transcript	uc010har.1	nonsynonymous SNV	exon13	c.G2156A	p.R719Q	QRLKEQFVKDQERRQAARQEELDDD	QRLKEQFVKDQEQRQAARQEELDDD	7.0	10.0	-	-	4320_22:50662684-50662684 C>T_QRLKEQFVKDQEQRQAARQEELDDD	0.0
X:54186007-54186007 A>C	1.0	2369	MELANOMA	-	-	-	-	FAM120C	uc004dsz.4,p.F248V|NM_001300788,p.F248V|ENST00000328235,p.F248V|uc011moh.2,p.F248V|NM_017848,p.F248V|ENST00000375180,p.F248V	protein_coding, processed_transcript	uc011moh.2	nonsynonymous SNV	exon2	c.T742G	p.F248V	QSLEDHHLEVVAFFRENGFHGLLAH	QSLEDHHLEVVAVFRENGFHGLLAH	6.0	10.0	-	-	2369_X:54186007-54186007 A>C_QSLEDHHLEVVAVFRENGFHGLLAH	0.0
11:2909613-2909613 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	SLC22A18AS	ENST00000455942,p.A84T|ENST00000533594,p.A187T|ENST00000526203,p.A84T|NM_007105,p.A187T|uc001lwv.4,p.A187T	protein_coding	uc001lwv.4	nonsynonymous SNV	exon4	c.G559A	p.A187T	CSEENAKAGGCSAFPLLLSQLGARM	CSEENAKAGGCSTFPLLLSQLGARM	4.0	10.0	-	-	4258_11:2909613-2909613 C>T_CSEENAKAGGCSTFPLLLSQLGARM	0.0
1:158639344-158639344 G>A	0.0	3775	CERVICAL	-	-	-	-	SPTA1	NM_003126,p.R563W|uc001fst.1,p.R563W|ENST00000368147,p.R563W|ENST00000368148,p.R563W	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon14	c.C1687T	p.R563W	ENIKAIRDGLLARRDALREKAATRR	ENIKAIRDGLLAWRDALREKAATRR	1.0	8.0	-	-	3775_1:158639344-158639344 G>A_ENIKAIRDGLLAWRDALREKAATRR	0.0
8:27151790-27151790 T>C	1.0	4320	COLORECTAL	-	-	-	-	TRIM35	ENST00000305364,p.E190G|uc010lup.1,p.E158G|ENST00000521253,p.E158G|uc003xfl.1,p.E190G|NM_171982,p.E190G	retained_intron, protein_coding	uc010lup.1	nonsynonymous SNV	exon2	c.A473G	p.E158G	VEAAWLEGRIRQEFDKLREFLRVEE	VEAAWLEGRIRQGFDKLREFLRVEE	6.0	3.0	-	-	4320_8:27151790-27151790 T>C_VEAAWLEGRIRQGFDKLREFLRVEE	0.0
17:43922661-43922661 C>T	0.0	4240	BREAST	-	-	-	-	SPPL2C	uc010wka.2,p.S130L|NM_175882,p.S130L|ENST00000329196,p.S130L	protein_coding	uc010wka.2	nonsynonymous SNV	exon1	c.C389T	p.S130L	LLIVSRVSDQQCSDTTLAPQDPRQP	LLIVSRVSDQQCLDTTLAPQDPRQP	1.0	10.0	-	-	4240_17:43922661-43922661 C>T_LLIVSRVSDQQCLDTTLAPQDPRQP	0.0
19:37382573-37382573 G>T	0.0	4245	COLORECTAL	-	-	-	-	ZNF829	ENST00000520965,p.H455N|NM_001171979,p.H455N|ENST00000391711,p.H374N|uc021utr.1,p.H455N|uc002ofa.2,p.H374N|NM_001037232,p.H374N	retained_intron, protein_coding	uc021utr.1	nonsynonymous SNV	exon6	c.C1363A	p.H455N	IQSSELIQHQRIHTDEKPYECNECG	IQSSELIQHQRINTDEKPYECNECG	5.0	2.0	-	-	4245_19:37382573-37382573 G>T_IQSSELIQHQRINTDEKPYECNECG	0.0
2:136111084-136111084 C>T	1.0	2591	MELANOMA	-	-	-	-	ZRANB3	ENST00000536680,p.E99K|uc002tul.3,p.E99K|uc002tun.1,p.E39K|ENST00000401392,p.E99K|NM_032143,p.E99K|uc002tum.3,p.E99K|ENST00000403017,p.E99K|ENST00000264159,p.E99K|NM_001286568,p.E99K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tun.1	nonsynonymous SNV	exon2	c.G115A	p.E39K	PSSLRYPWTEEIEKWIPELSPEEIN	PSSLRYPWTEEIKKWIPELSPEEIN	6.0	6.0	-	-	2591_2:136111084-136111084 C>T_PSSLRYPWTEEIKKWIPELSPEEIN	0.0
7:117067469-117067469 C>T	0.0	4301	MELANOMA	-	-	ID=COSM598560;OCCURENCE=1(lung)	-	ASZ1	ENST00000450714,p.E16K|uc003vjb.2,p.E16K|ENST00000284629,p.E16K|NM_130768,p.E16K|uc011kno.1,p.E16K|NM_001301821,p.E16K	retained_intron, protein_coding, nonsense_mediated_decay	uc011kno.1	nonsynonymous SNV	exon1	c.G46A	p.E16K	SALRGLPVAGGGESSESEDDGWEIG	SALRGLPVAGGGKSSESEDDGWEIG	1.0	10.0	-	-	4301_7:117067469-117067469 C>T_SALRGLPVAGGGKSSESEDDGWEIG	0.0
22:31333588-31333588 G>A	1.0	3466	MELANOMA	-	-	-	-	MORC2	ENST00000397641,p.P494S|ENST00000215862,p.P432S|NM_014941,p.P432S|uc003aje.1,p.P432S	retained_intron, protein_coding, processed_transcript	uc003aje.1	nonsynonymous SNV	exon16	c.C1294T	p.P432S	ELRYKRRRAMEIPTTIQCDLCLKWR	ELRYKRRRAMEISTTIQCDLCLKWR	8.0	3.0	-	-	3466_22:31333588-31333588 G>A_ELRYKRRRAMEISTTIQCDLCLKWR	0.0
3:30769838-30769838 C>T	0.0	3903	MELANOMA	-	-	-	-	GADL1	ENST00000282538,p.G488R|uc003cep.2,p.G488R|NM_207359,p.G488R	protein_coding, processed_transcript	uc003cep.2	nonsynonymous SNV	exon15	c.G1462A	p.G488R	KGSLMLGYQPHRGKVNFFRQVVISP	KGSLMLGYQPHRRKVNFFRQVVISP	1.0	8.0	-	-	3903_3:30769838-30769838 C>T_KGSLMLGYQPHRRKVNFFRQVVISP	0.0
2:96956144-96956144 G>A	1.0	3466	MELANOMA	-	-	-	-	SNRNP200	NM_014014,p.P888S|ENST00000323853,p.P888S|uc002svu.3,p.P888S	retained_intron, protein_coding, nonsense_mediated_decay	uc002svu.3	nonsynonymous SNV	exon20	c.C2662T	p.P888S	LQYYLSLLNQQLPIESQMVSKLPDM	LQYYLSLLNQQLSIESQMVSKLPDM	10.0	7.0	-	-	3466_2:96956144-96956144 G>A_LQYYLSLLNQQLSIESQMVSKLPDM	0.0
1:32256329-32256329 G>A	1.0	4155	MELANOMA	0.0027	-	-	-	SPOCD1	NM_001281988,p.P656S|NM_144569,p.P1176S|uc001btv.3,p.P656S|uc001btu.3,p.P1163S|uc001bts.1,p.P1176S|ENST00000533231,p.P1163S|NM_001281987,p.P1163S|ENST00000452755,p.P599S|ENST00000360482,p.P1176S|ENST00000257100,p.P656S	retained_intron, protein_coding	uc001btv.3	nonsynonymous SNV	exon15	c.C1966T	p.P656S	QALLCPQTKSSIPRPLQRLSSALAA	QALLCPQTKSSISRPLQRLSSALAA	6.0	10.0	-	-	4155_1:32256329-32256329 G>A_QALLCPQTKSSISRPLQRLSSALAA	0.0
13:32749722-32749722 A>C	1.0	4320	COLORECTAL	-	-	-	-	FRY	uc001utx.3,p.S792R|ENST00000380250,p.S792R|NM_023037,p.S792R	protein_coding, processed_transcript, nonsense_mediated_decay	uc001utx.3	nonsynonymous SNV	exon20	c.A2374C	p.S792R	DDRPMIDVMDQLSSSILESFIHVAV	DDRPMIDVMDQLRSSILESFIHVAV	6.0	2.0	-	-	4320_13:32749722-32749722 A>C_DDRPMIDVMDQLRSSILESFIHVAV	0.0
5:9122831-9122831 G>A	1.0	4237	NSCLC	-	-	-	-	SEMA5A	ENST00000382496,p.P573L|uc003jek.2,p.P573L|NM_003966,p.P573L	protein_coding, nonsense_mediated_decay	uc003jek.2	nonsynonymous SNV	exon14	c.C1718T	p.P573L	GSCLCRTRSCDSPAPQCGGWQCEGP	GSCLCRTRSCDSLAPQCGGWQCEGP	6.0	9.0	-	-	4237_5:9122831-9122831 G>A_GSCLCRTRSCDSLAPQCGGWQCEGP	0.0
11:122709283-122709283 C>A	0.0	4259	COLORECTAL	-	-	-	-	CRTAM	uc001pyj.3,p.A10E|ENST00000227348,p.A10E|NM_019604,p.A10E	retained_intron, protein_coding	uc001pyj.3	nonsynonymous SNV	exon1	c.C29A	p.A10E	MWWRVLSLLAWFPLQEASLTNH	MWWRVLSLLEWFPLQEASLTNH	4.0	5.0	-	-	4259_11:122709283-122709283 C>A_MWWRVLSLLEWFPLQEASLTNH	0.0
7:73791033-73791033 C>G	1.0	3713	MELANOMA	-	-	-	-	CLIP2	ENST00000395060,p.R768G|ENST00000223398,p.R768G|NM_032421,p.R733G|uc003uam.3,p.R768G|uc003uan.3,p.R733G|ENST00000361545,p.R733G|uc003uao.3,p.R162G|NM_003388,p.R768G	retained_intron, protein_coding	uc003uao.3	nonsynonymous SNV	exon1	c.C484G	p.R162G	ISLAEKKMLDYERLQRAEAQGKQEV	ISLAEKKMLDYEGLQRAEAQGKQEV	8.0	9.0	-	-	3713_7:73791033-73791033 C>G_ISLAEKKMLDYEGLQRAEAQGKQEV	0.0
7:144060804-144060804 T>G	1.0	4252	COLORECTAL	-	-	-	-	ARHGEF5	NM_005435,p.F348V|ENST00000056217,p.F348V|uc003wel.3,p.F348V|uc003wek.3,p.F348V	protein_coding	uc003wel.3	nonsynonymous SNV	exon2	c.T1042G	p.F348V	NRADSQDEKSQTFLGKSEEVTGKQE	NRADSQDEKSQTVLGKSEEVTGKQE	9.0	4.0	-	-	4252_7:144060804-144060804 T>G_NRADSQDEKSQTVLGKSEEVTGKQE	0.0
4:125592226-125592226 C>A	1.0	4134	NSCLC	-	-	-	-	ANKRD50	NM_001167882,p.D557Y|uc011cgo.2,p.D557Y|ENST00000515641,p.D557Y|NM_020337,p.D736Y|ENST00000504087,p.D736Y|uc010inw.3,p.D736Y	protein_coding	uc011cgo.2	nonsynonymous SNV	exon3	c.G1669T	p.D557Y	SKGHASVVSLLIDRGAEVDHCDKDG	SKGHASVVSLLIYRGAEVDHCDKDG	6.0	4.0	-	-	4134_4:125592226-125592226 C>A_SKGHASVVSLLIYRGAEVDHCDKDG	0.0
19:327884-327884 G>A	1.0	3713	MELANOMA	-	-	-	-	MIER2	ENST00000264819,p.P117S|NM_017550,p.P117S|uc002lok.1,p.P117S	retained_intron, protein_coding	uc002lok.1	nonsynonymous SNV	exon4	c.C349T	p.P117S	RESEGGDVAPNLPDMTLDKEQIAKD	RESEGGDVAPNLSDMTLDKEQIAKD	4.0	4.0	-	-	3713_19:327884-327884 G>A_RESEGGDVAPNLSDMTLDKEQIAKD	0.0
19:56329414-56329414 G>A	0.0	2369	MELANOMA	-	-	-	-	NLRP11	ENST00000443188,p.P43S|ENST00000589824,p.P43S|ENST00000589093,p.P43S|ENST00000360133,p.P43S|uc010ygf.2,p.P43S|NM_145007,p.P43S|ENST00000593244,p.P43S	protein_coding, nonsense_mediated_decay	uc010ygf.2	nonsynonymous SNV	exon4	c.C127T	p.P43S	ARKILDFKLPQFPLIQMTKEELANV	ARKILDFKLPQFSLIQMTKEELANV	5.0	5.0	-	-	2369_19:56329414-56329414 G>A_ARKILDFKLPQFSLIQMTKEELANV	0.0
9:131765186-131765186 A>C	1.0	4245	COLORECTAL	-	-	-	-	NUP188	uc004bws.2,p.T1410P|uc004bwu.3,p.T753P|ENST00000372577,p.T1410P|NM_015354,p.T1410P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004bwu.3	nonsynonymous SNV	exon18	c.A2257C	p.T753P	RLSMSLMEQLLKTLRYNFLPEALDF	RLSMSLMEQLLKPLRYNFLPEALDF	7.0	4.0	-	-	4245_9:131765186-131765186 A>C_RLSMSLMEQLLKPLRYNFLPEALDF	0.0
7:7480446-7480446 C>A	0.0	4245	COLORECTAL	-	-	-	-	COL28A1	uc011jxe.1,p.G249V|ENST00000399429,p.G566V|uc003src.1,p.G566V|NM_001037763,p.G566V|uc003srd.3,p.G121V	retained_intron, protein_coding, nonsense_mediated_decay	uc011jxe.1	nonsynonymous SNV	exon22	c.G746T	p.G249V	GKKGSKGNQGQRGLPGPEGPKGEPG	GKKGSKGNQGQRVLPGPEGPKGEPG	4.0	10.0	-	-	4245_7:7480446-7480446 C>A_GKKGSKGNQGQRVLPGPEGPKGEPG	0.0
11:6653496-6653496 C>T	0.0	4110	BILE DUCT	-	-	-	-	DCHS1	NM_003737,p.G1083R|uc001mem.1,p.G1083R|ENST00000299441,p.G1083R	protein_coding	uc001mem.1	nonsynonymous SNV	exon6	c.G3247A	p.G1083R	KVMAVSGSKAELGQQTGTATVRVSI	KVMAVSGSKAELRQQTGTATVRVSI	2.0	8.0	-	-	4110_11:6653496-6653496 C>T_KVMAVSGSKAELRQQTGTATVRVSI	0.0
19:6586405-6586405 C>T	1.0	3713	MELANOMA	-	-	-	-	CD70	NM_001252,p.D70N|uc010xjf.1,p.D70N|ENST00000245903,p.D70N|uc002mfi.3,p.D70N|ENST00000423145,p.D70N	protein_coding	uc010xjf.1	nonsynonymous SNV	exon3	c.G208A	p.D70N	AELQLNHTGPQQDPRLYWQGGPALG	AELQLNHTGPQQNPRLYWQGGPALG	2.0	10.0	-	-	3713_19:6586405-6586405 C>T_AELQLNHTGPQQNPRLYWQGGPALG	0.0
1:159162383-159162383 G>A	1.0	3713	MELANOMA	-	-	ID=COSM897972;OCCURENCE=1(endometrium),1(skin)	-	CADM3	uc001ftk.2,p.R116Q|NM_001127173,p.R82Q|ENST00000416746,p.R82Q|ENST00000368125,p.R82Q|uc001ftl.2,p.R82Q|ENST00000368124,p.R116Q|NM_021189,p.R116Q|uc009wsx.1,p.R116Q|uc009wsy.1,p.R82Q	protein_coding, processed_transcript	uc009wsy.1	nonsynonymous SNV	exon3	c.G245A	p.R82Q	LYFGEKRALRDNRIQLVTSTPHELS	LYFGEKRALRDNQIQLVTSTPHELS	10.0	5.0	-	-	3713_1:159162383-159162383 G>A_LYFGEKRALRDNQIQLVTSTPHELS	0.0
4:91230226-91230226 C>T	1.0	4129	NSCLC	-	-	-	-	CCSER1	uc003hsw.3,p.T264I|NM_001145065,p.T264I|uc003hsu.3,p.T264I|ENST00000509176,p.T264I|NM_207491,p.T264I|ENST00000505073,p.T264I|uc003hsv.4,p.T264I|ENST00000333691,p.T264I|ENST00000432775,p.T264I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003hsw.3	nonsynonymous SNV	exon2	c.C791T	p.T264I	TTAQTPSEFLALTEDSVSEMDAFSK	TTAQTPSEFLALIEDSVSEMDAFSK	2.0	3.0	-	-	4129_4:91230226-91230226 C>T_TTAQTPSEFLALIEDSVSEMDAFSK	0.0
4:102117208-102117208 G>A	1.0	3713	MELANOMA	-	-	-	-	PPP3CA	ENST00000512215,p.R42C|ENST00000394853,p.R42C|ENST00000394854,p.R42C|uc010ilj.2,p.R42C|NM_000944,p.R42C|uc010ilk.2,p.R42C|uc003hvt.2,p.R29C|NM_001130692,p.R42C|ENST00000323055,p.R42C|uc003hvu.2,p.R42C|uc011cen.1,p.R42C|NM_001130691,p.R42C	protein_coding, processed_transcript, nonsense_mediated_decay	uc011cen.1	nonsynonymous SNV	exon2	c.C124T	p.R42C	TAKEVFDNDGKPRVDILKAHLMKEG	TAKEVFDNDGKPCVDILKAHLMKEG	6.0	5.0	-	-	3713_4:102117208-102117208 G>A_TAKEVFDNDGKPCVDILKAHLMKEG	0.0
2:136630367-136630367 C>T	1.0	4258	ENDOMETRIAL	-	-	-	-	MCM6	uc002tuw.4,p.E52K|NM_005915,p.E52K|ENST00000264156,p.E52K	retained_intron, protein_coding, processed_transcript	uc002tuw.4	nonsynonymous SNV	exon2	c.G154A	p.E52K	SDGEIKYLQLAEELIRPERNTLVVS	SDGEIKYLQLAEKLIRPERNTLVVS	9.0	7.0	CD8	-	4258_2:136630367-136630367 C>T_SDGEIKYLQLAEKLIRPERNTLVVS	2.0
X:53111841-53111841 C>T	0.0	4081	COLORECTAL	-	-	-	-	TSPYL2	uc004drv.3,p.A54V|ENST00000375442,p.A54V|NM_022117,p.A54V|uc004drw.3,p.A54V	retained_intron, protein_coding, nonsense_mediated_decay	uc004drw.3	nonsynonymous SNV	exon1	c.C161T	p.A54V	PQQRPRLQEETEAAQVLADMRGVGL	PQQRPRLQEETEVAQVLADMRGVGL	5.0	5.0	-	-	4081_X:53111841-53111841 C>T_PQQRPRLQEETEVAQVLADMRGVGL	0.0
7:99751562-99751562 G>C	1.0	4240	BREAST	-	-	-	-	LAMTOR4	ENST00000341942,p.R92P|uc003utq.2,p.R92P|NM_001008395,p.R92P	retained_intron, protein_coding, processed_transcript	uc003utq.2	nonsynonymous SNV	exon4	c.G275C	p.R92P	SGQRVFVVKRQNRGREPIDV	SGQRVFVVKRQNPGREPIDV	10.0	9.0	-	-	4240_7:99751562-99751562 G>C_SGQRVFVVKRQNPGREPIDV	0.0
5:170818389-170818389 A>C	1.0	4037	NSCLC	-	-	-	1	NPM1	uc003mbi.3,p.K73N|ENST00000296930,p.K73N|NM_199185,p.K73N|NM_001037738,p.K73N|ENST00000517671,p.K73N|uc003mbh.3,p.K73N|uc003mbj.3,p.K73N|ENST00000351986,p.K73N|NM_002520,p.K73N|ENST00000393820,p.K73N	retained_intron, protein_coding	uc003mbj.3	nonsynonymous SNV	exon3	c.A219C	p.K73N	EAEAMNYEGSPIKVTLATLKMSVQP	EAEAMNYEGSPINVTLATLKMSVQP	10.0	8.0	CD8	-	4037_5:170818389-170818389 A>C_EAEAMNYEGSPINVTLATLKMSVQP	1.0
4:3441325-3441325 C>G	1.0	3775	CERVICAL	-	-	-	-	RGS12	uc003ggw.3,p.P1420A|uc010icv.3,p.P619A|uc003gha.3,p.P762A|ENST00000338806,p.P772A|NM_198227,p.P772A|ENST00000344733,p.P1420A|NM_198229,p.P1420A|uc003ggz.3,p.P772A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010icv.3	nonsynonymous SNV	exon14	c.C1855G	p.P619A	AGPGRSQASGGPPTSDLPGLGPVPG	AGPGRSQASGGPATSDLPGLGPVPG	9.0	7.0	-	-	3775_4:3441325-3441325 C>G_AGPGRSQASGGPATSDLPGLGPVPG	0.0
11:237103-237103 G>T	1.0	4071	COLORECTAL	-	-	-	-	PSMD13	NM_002817,p.Q18H|NM_175932,p.Q18H|ENST00000525665,p.Q18H|ENST00000352303,p.Q18H|ENST00000382671,p.Q18H|uc001lol.2,p.Q18H|ENST00000431206,p.Q18H|uc001loo.2,p.Q18H|ENST00000532097,p.Q18H|ENST00000529372,p.Q18H|ENST00000528906,p.Q18H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001loo.2	nonsynonymous SNV	exon1	c.G54T	p.Q18H	GFLQQSQNSGPGQPAVWHRLEELYT	GFLQQSQNSGPGHPAVWHRLEELYT	9.0	9.0	-	-	4071_11:237103-237103 G>T_GFLQQSQNSGPGHPAVWHRLEELYT	0.0
7:100642866-100642866 C>A	0.0	4237	NSCLC	-	-	-	-	MUC12	uc003uxo.3,p.P3008T|ENST00000536621,p.P3008T|ENST00000379442,p.P3151T|NM_001164462,p.P3008T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003uxo.3	nonsynonymous SNV	exon2	c.C9022A	p.P3008T	TFQSWPSSSDTTPSPPGTTAAPVEV	TFQSWPSSSDTTTSPPGTTAAPVEV	5.0	7.0	-	-	4237_7:100642866-100642866 C>A_TFQSWPSSSDTTTSPPGTTAAPVEV	0.0
15:72192104-72192104 T>G	1.0	4320	COLORECTAL	-	-	-	-	MYO9A	uc010biq.4,p.S752R|ENST00000424560,p.S1132R|ENST00000356056,p.S1132R|ENST00000564571,p.S1132R|uc002atl.5,p.S1132R|ENST00000566885,p.S752R|uc002atn.1,p.S1113R|ENST00000444904,p.S1113R|NM_006901,p.S1132R	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010biq.4	nonsynonymous SNV	exon22	c.A2254C	p.S752R	ICIQARWKAYRESKRYQEQRKKIIL	ICIQARWKAYRERKRYQEQRKKIIL	8.0	3.0	-	-	4320_15:72192104-72192104 T>G_ICIQARWKAYRERKRYQEQRKKIIL	0.0
12:123082472-123082472 G>A	1.0	2591	MELANOMA	-	-	-	-	KNTC1	NM_014708,p.G1517E|uc001ucv.3,p.G1517E|ENST00000333479,p.G1517E|ENST00000423927,p.G76E	retained_intron, protein_coding, processed_transcript	uc001ucv.3	nonsynonymous SNV	exon44	c.G4550A	p.G1517E	LTSTKDLVISLSGILHKLDPYDYEM	LTSTKDLVISLSEILHKLDPYDYEM	7.0	6.0	-	-	2591_12:123082472-123082472 G>A_LTSTKDLVISLSEILHKLDPYDYEM	0.0
12:116434861-116434861 A>C	1.0	4240	BREAST	-	-	-	-	MED13L	uc001tvw.3,p.M915R|ENST00000281928,p.M915R|NM_015335,p.M915R	retained_intron, protein_coding, processed_transcript	uc001tvw.3	nonsynonymous SNV	exon15	c.T2744G	p.M915R	VSMVSTQLTEFKMEVEDGLGSPKPE	VSMVSTQLTEFKREVEDGLGSPKPE	9.0	7.0	-	-	4240_12:116434861-116434861 A>C_VSMVSTQLTEFKREVEDGLGSPKPE	0.0
19:50099778-50099778 A>C	0.0	4335	COLORECTAL	-	-	-	-	PRR12	uc002poo.4,p.K729T|NM_020719,p.K729T|ENST00000418929,p.K729T	retained_intron, protein_coding	uc002poo.4	nonsynonymous SNV	exon4	c.A2186C	p.K729T	ALELGLGRLKEKKKGPERGGETPEG	ALELGLGRLKEKTKGPERGGETPEG	7.0	6.0	-	-	4335_19:50099778-50099778 A>C_ALELGLGRLKEKTKGPERGGETPEG	0.0
16:83065641-83065641 G>A	0.0	3713	MELANOMA	-	-	-	-	CDH13	ENST00000446376,p.D62N|NM_001220491,p.D62N|NM_001220489,p.D62N|uc010vnu.2,p.D62N|NM_001257,p.D62N|ENST00000566620,p.D62N|NM_001220488,p.D109N|ENST00000431540,p.D62N|NM_001220492,p.D62N|uc002fgx.3,p.D62N|uc010chh.3,p.D62N|ENST00000565636,p.D62N|ENST00000428848,p.D62N|ENST00000268613,p.D109N|uc010vns.2,p.D109N|uc021tlw.1,p.D62N	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021tlw.1	nonsynonymous SNV	exon3	c.G184A	p.D62N	ILNLTFSDCKGNDKLRYEVSSPYFK	ILNLTFSDCKGNNKLRYEVSSPYFK	3.0	2.0	-	-	3713_16:83065641-83065641 G>A_ILNLTFSDCKGNNKLRYEVSSPYFK	0.0
18:43217053-43217053 C>T	0.0	4160	COLORECTAL	-	-	-	-	SLC14A2	NM_001242692,p.A250V|uc002lbe.3,p.A250V|uc002lbb.3,p.A250V|uc010dnj.3,p.A250V|ENST00000255226,p.A250V|ENST00000586448,p.A250V|NM_007163,p.A250V	protein_coding, nonsense_mediated_decay	uc010dnj.3	nonsynonymous SNV	exon7	c.C749T	p.A250V	LPFNIAVTLYLAATGHYNLFFPTTL	LPFNIAVTLYLAVTGHYNLFFPTTL	1.0	6.0	-	-	4160_18:43217053-43217053 C>T_LPFNIAVTLYLAVTGHYNLFFPTTL	0.0
3:56809134-56809134 T>G	0.0	4345	COLORECTAL	-	-	-	-	ARHGEF3	ENST00000497267,p.E3A|uc011bev.1,p.E3A	protein_coding, processed_transcript, nonsense_mediated_decay	uc011bev.1	nonsynonymous SNV	exon1	c.A8C	p.E3A	MIEEPSNKRVKPLSR	MIAEPSNKRVKPLSR	7.0	6.0	-	-	4345_3:56809134-56809134 T>G_MIAEPSNKRVKPLSR	0.0
11:32955998-32955998 T>C	1.0	2591	MELANOMA	-	-	-	-	QSER1	uc001mtz.1,p.L697P|uc001mty.3,p.L936P|ENST00000527788,p.L697P|NM_001076786,p.L936P|ENST00000399302,p.L936P|uc001mua.3,p.L441P	retained_intron, protein_coding, processed_transcript	uc001mua.3	nonsynonymous SNV	exon1	c.T1322C	p.L441P	NQVTVNLSPVPALQSKMTLDQQHIE	NQVTVNLSPVPAPQSKMTLDQQHIE	6.0	3.0	-	-	2591_11:32955998-32955998 T>C_NQVTVNLSPVPAPQSKMTLDQQHIE	0.0
22:30887938-30887938 G>A	0.0	3795	MELANOMA	-	-	-	-	SEC14L4	uc011akz.1,p.P265L|NM_174977,p.P265L|uc003aid.2,p.P265L|NM_001161368,p.P265L|uc003aif.2,p.P211L|ENST00000255858,p.P265L|ENST00000392772,p.P211L|ENST00000381982,p.P265L|uc003aie.2,p.P250L|ENST00000540456,p.P250L	protein_coding, nonsense_mediated_decay	uc011akz.1	nonsynonymous SNV	exon10	c.C794T	p.P265L	KCLTKINYGGEVPKSYYLCEQVRLQ	KCLTKINYGGEVLKSYYLCEQVRLQ	1.0	7.0	-	-	3795_22:30887938-30887938 G>A_KCLTKINYGGEVLKSYYLCEQVRLQ	0.0
1:243328281-243328281 C>A	1.0	4196	COLORECTAL	-	-	-	-	CEP170	NM_001042405,p.S896I|uc001hzv.1,p.S372I|ENST00000366544,p.S896I|uc021plq.1,p.S896I|ENST00000366543,p.S896I|NM_001042404,p.S896I|uc021plo.1,p.S994I|ENST00000366542,p.S994I|NM_014812,p.S994I|uc021plp.1,p.S896I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021plq.1	nonsynonymous SNV	exon12	c.G2687T	p.S896I	SGAREKMEKKTKSRSTDVGSRADGR	SGAREKMEKKTKIRSTDVGSRADGR	9.0	7.0	-	-	4196_1:243328281-243328281 C>A_SGAREKMEKKTKIRSTDVGSRADGR	0.0
1:9063447-9063447 C>T	0.0	2591	MELANOMA	-	-	-	-	SLC2A7	ENST00000400906,p.R484K|NM_207420,p.R484K|uc009vmo.1,p.R484K	protein_coding	uc009vmo.1	nonsynonymous SNV	exon12	c.G1451A	p.R484K	KTFVEINRIFAKRNRVKLPEEKEET	KTFVEINRIFAKKNRVKLPEEKEET	1.0	4.0	-	-	2591_1:9063447-9063447 C>T_KTFVEINRIFAKKNRVKLPEEKEET	0.0
22:46326985-46326985 C>A	0.0	4287	COLORECTAL	-	-	-	-	WNT7B	uc010haa.2,p.G192V|uc003bgo.2,p.G188V|NM_058238,p.G188V|ENST00000339464,p.G188V|ENST00000409496,p.G192V|ENST00000410089,p.G172V	protein_coding	uc010haa.2	nonsynonymous SNV	exon3	c.G575T	p.G192V	ARRLMNLHNNEAGRKVLEDRMQLEC	ARRLMNLHNNEAVRKVLEDRMQLEC	1.0	9.0	-	-	4287_22:46326985-46326985 C>A_ARRLMNLHNNEAVRKVLEDRMQLEC	0.0
4:187130267-187130267 G>T	0.0	4246	COLORECTAL	-	-	-	-	CYP4V2	NM_207352,p.G416C|ENST00000378802,p.G416C|uc003iyw.4,p.G416C	 processed_transcript, protein_coding,retained_intron	uc003iyw.4	nonsynonymous SNV	exon10	c.G1246T	p.G416C	EDCEVAGYRVLKGTEAVIIPYALHR	EDCEVAGYRVLKCTEAVIIPYALHR	5.0	6.0	-	-	4246_4:187130267-187130267 G>T_EDCEVAGYRVLKCTEAVIIPYALHR	0.0
9:104432505-104432505 C>T	0.0	3903	MELANOMA	-	-	-	-	GRIN3A	NM_133445,p.R730K|uc004bbp.2,p.R730K|ENST00000361820,p.R730K|uc004bbq.1,p.R730K	protein_coding, processed_transcript	uc004bbq.1	nonsynonymous SNV	exon3	c.G2189A	p.R730K	SALNICYALLFGRTVAIKPPKCWTG	SALNICYALLFGKTVAIKPPKCWTG	3.0	10.0	-	-	3903_9:104432505-104432505 C>T_SALNICYALLFGKTVAIKPPKCWTG	0.0
5:140711683-140711683 G>A	1.0	2556	MELANOMA	-	-	-	-	PCDHGA1	uc011dan.2,p.D478N|ENST00000378105,p.D478N|uc003lji.2,p.D478N|NM_018912,p.D478N|NM_031993,p.D478N|ENST00000517417,p.D478N	protein_coding	uc011dan.2	nonsynonymous SNV	exon1	c.G1432A	p.D478N	PRGASIFSVRAHDLDSNENAQITYS	PRGASIFSVRAHNLDSNENAQITYS	5.0	8.0	-	-	2556_5:140711683-140711683 G>A_PRGASIFSVRAHNLDSNENAQITYS	0.0
12:25243087-25243087 G>A	0.0	4126	NSCLC	-	-	-	-	LRMP	uc001rgh.3,p.E188K|ENST00000354454,p.E188K|NM_001204127,p.E188K|ENST00000547044,p.E188K|ENST00000536173,p.E135K|uc010sjd.2,p.E135K|ENST00000361433,p.E188K|ENST00000548766,p.E188K|uc010sjc.2,p.E188K|uc010sja.2,p.E188K|NM_001204126,p.E188K|NM_006152,p.E188K|uc010sjb.2,p.E135K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sjd.2	nonsynonymous SNV	exon9	c.G403A	p.E135K	VKLEERSRDLAEENLKKEITNCLKL	VKLEERSRDLAEKNLKKEITNCLKL	4.0	2.0	-	-	4126_12:25243087-25243087 G>A_VKLEERSRDLAEKNLKKEITNCLKL	0.0
3:52256957-52256957 C>T	0.0	3713	MELANOMA	-	-	-	-	TLR9	ENST00000360658,p.D459N|ENST00000597542,p.D483N|uc003dda.2,p.D459N|NM_017442,p.D459N|uc003ddb.3,p.D556N	protein_coding	uc003ddb.3	nonsynonymous SNV	exon5	c.G1666A	p.D556N	WLQPGDLAPAPVDTPSSEDFRPNCS	WLQPGDLAPAPVNTPSSEDFRPNCS	2.0	6.0	-	-	3713_3:52256957-52256957 C>T_WLQPGDLAPAPVNTPSSEDFRPNCS	0.0
1:156035812-156035812 C>T	1.0	4240	BREAST	-	-	-	-	RAB25	ENST00000361084,p.R52C|NM_020387,p.R52C|uc001fnc.3,p.R52C	protein_coding, processed_transcript	uc001fnc.3	nonsynonymous SNV	exon2	c.C154T	p.R52C	DSRTTIGVEFSTRTVMLGTAAVKAQ	DSRTTIGVEFSTCTVMLGTAAVKAQ	10.0	1.0	-	-	4240_1:156035812-156035812 C>T_DSRTTIGVEFSTCTVMLGTAAVKAQ	0.0
11:2417152-2417152 G>T	1.0	3466	MELANOMA	-	-	-	-	CD81	ENST00000481687,p.K177N|NM_004356,p.K171N|ENST00000492252,p.K164N|ENST00000381036,p.K209N|ENST00000527343,p.K160N|NM_001297649,p.K100N|ENST00000526072,p.K100N|ENST00000492627,p.K100N|ENST00000263645,p.K171N|uc001lwf.1,p.K171N	retained_intron, protein_coding, processed_transcript	uc001lwf.1	nonsynonymous SNV	exon6	c.G513T	p.K171N	SSTLTALTTSVLKNNLCPSGSNIIS	SSTLTALTTSVLNNNLCPSGSNIIS	10.0	7.0	-	-	3466_11:2417152-2417152 G>T_SSTLTALTTSVLNNNLCPSGSNIIS	0.0
16:28331829-28331829 G>A	0.0	4346	COLORECTAL	-	-	-	-	SBK1	ENST00000341901,p.A288T|NM_001024401,p.A288T|uc002dpd.3,p.A288T	protein_coding	uc002dpd.3	nonsynonymous SNV	exon4	c.G862A	p.A288T	GLPSQWRRFTEPALRMFQRLLALEP	GLPSQWRRFTEPTLRMFQRLLALEP	3.0	1.0	-	-	4346_16:28331829-28331829 G>A_GLPSQWRRFTEPTLRMFQRLLALEP	0.0
9:137716509-137716509 G>A	0.0	4213	COLORECTAL	-	-	-	-	COL5A1	ENST00000371817,p.D1588N|uc004cfe.4,p.D1588N|NM_001278074,p.D1588N|uc031tfl.1,p.D1588N|NM_000093,p.D1588N	retained_intron, protein_coding, processed_transcript	uc031tfl.1	nonsynonymous SNV	exon62	c.G4762A	p.D1588N	LPIQASRTRRNIDASQLLDDGNGEN	LPIQASRTRRNINASQLLDDGNGEN	9.0	7.0	-	-	4213_9:137716509-137716509 G>A_LPIQASRTRRNINASQLLDDGNGEN	0.0
7:151053265-151053265 A>C	1.0	4335	COLORECTAL	-	-	-	-	NUB1	ENST00000566856,p.N217T|ENST00000413040,p.N241T|ENST00000568733,p.N241T|NM_001243351,p.N241T|NM_016118,p.N241T|uc003wjx.3,p.N241T|ENST00000355851,p.N217T|ENST00000468404,p.N217T|ENST00000483358,p.N217T|uc003wjw.4,p.N241T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003wjx.3	nonsynonymous SNV	exon7	c.A722C	p.N241T	VDPEMTPYLDIANQTGRSIRIPPSE	VDPEMTPYLDIATQTGRSIRIPPSE	10.0	4.0	-	-	4335_7:151053265-151053265 A>C_VDPEMTPYLDIATQTGRSIRIPPSE	0.0
19:36034575-36034575 C>G	1.0	4046	OVARIAN	-	-	-	-	GAPDHS	ENST00000222286,p.T301R|NM_014364,p.T301R|uc002oaf.1,p.T301R	protein_coding, nonsense_mediated_decay	uc002oaf.1	nonsynonymous SNV	exon9	c.C902G	p.T301R	VTKVIPELKGKLTGMAFRVPTPDVS	VTKVIPELKGKLRGMAFRVPTPDVS	2.0	5.0	-	-	4046_19:36034575-36034575 C>G_VTKVIPELKGKLRGMAFRVPTPDVS	0.0
10:15256479-15256479 C>A	1.0	4078	GASTRIC	-	-	-	-	FAM171A1	NM_001010924,p.A370S|uc001iob.3,p.A370S|ENST00000378116,p.A370S	protein_coding, processed_transcript	uc001iob.3	nonsynonymous SNV	exon8	c.G1108T	p.A370S	SMSHINLLFSRRASEFPGPLSVTSH	SMSHINLLFSRRSSEFPGPLSVTSH	5.0	1.0	-	-	4078_10:15256479-15256479 C>A_SMSHINLLFSRRSSEFPGPLSVTSH	0.0
1:156846244-156846244 A>C	0.0	4335	COLORECTAL	-	-	-	1	NTRK1	ENST00000524377,p.E562A|ENST00000358660,p.E559A|ENST00000392302,p.E526A|ENST00000368196,p.E556A|NM_001012331,p.E556A|NM_001007792,p.E526A|uc009wsk.1,p.E559A|NM_002529,p.E562A|uc001fqi.1,p.E556A|uc009wsi.1,p.E261A|uc001fqh.1,p.E562A|uc001fqf.1,p.E526A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009wsk.1	nonsynonymous SNV	exon13	c.A1676C	p.E559A	SESARQDFQREAELLTMLQHQHIVR	SESARQDFQREAALLTMLQHQHIVR	5.0	4.0	-	-	4335_1:156846244-156846244 A>C_SESARQDFQREAALLTMLQHQHIVR	0.0
3:129696006-129696006 C>T	0.0	4158	COLORECTAL	0.0014	-	-	-	TRH	NM_007117,p.R226W|ENST00000302649,p.R226W|uc003enc.4,p.R226W|ENST00000507066,p.R222W	protein_coding	uc003enc.4	nonsynonymous SNV	exon3	c.C676T	p.R226W	DDLSRSQGAEEKRQHPGRRAAWVRE	DDLSRSQGAEEKWQHPGRRAAWVRE	5.0	5.0	-	-	4158_3:129696006-129696006 C>T_DDLSRSQGAEEKWQHPGRRAAWVRE	0.0
19:54403680-54403680 G>A	0.0	4246	COLORECTAL	-	-	ID=COSM1000933,COSM1000934;OCCURENCE=1(endometrium)	-	PRKCG	uc002qcq.1,p.A461T|uc010yeh.1,p.A348T|ENST00000540413,p.A461T|ENST00000263431,p.A461T|NM_002739,p.A461T|ENST00000542049,p.A348T|uc010yeg.1,p.A461T	protein_coding	uc010yeh.1	nonsynonymous SNV	exon11	c.G1042A	p.A348T	LGKFKEPHAAFYAAEIAIGLFFLHN	LGKFKEPHAAFYTAEIAIGLFFLHN	1.0	5.0	-	-	4246_19:54403680-54403680 G>A_LGKFKEPHAAFYTAEIAIGLFFLHN	0.0
6:153345480-153345480 T>G	0.0	4346	COLORECTAL	-	-	-	-	RGS17	uc003qpm.3,p.K121Q|ENST00000206262,p.K121Q|ENST00000367225,p.K121Q|NM_012419,p.K121Q	protein_coding	uc003qpm.3	nonsynonymous SNV	exon4	c.A361C	p.K121Q	ENLLFWLACEDLKKEQNKKVIEEKA	ENLLFWLACEDLQKEQNKKVIEEKA	1.0	3.0	-	-	4346_6:153345480-153345480 T>G_ENLLFWLACEDLQKEQNKKVIEEKA	0.0
X:122551780-122551780 A>T	0.0	4160	COLORECTAL	-	-	-	-	GRIA3	uc011muf.1,p.L660F|ENST00000541091,p.L660F	protein_coding, processed_transcript	uc011muf.1	nonsynonymous SNV	exon11	c.A1980T	p.L660F	SNDRLSSSHCVCLCP	SNDRLSSSHCVCFCP	2.0	6.0	-	-	4160_X:122551780-122551780 A>T_SNDRLSSSHCVCFCP	0.0
8:146068129-146068129 T>G	1.0	4245	COLORECTAL	-	-	-	-	ZNF7	ENST00000446747,p.V557G|NM_001282795,p.V557G|uc003zek.4,p.V450G|ENST00000528372,p.V546G|uc003zeg.4,p.V546G|NM_001282797,p.V450G|ENST00000544249,p.V450G|uc011lln.2,p.V450G|uc010mge.3,p.V557G|ENST00000325241,p.V546G|NM_003416,p.V546G	retained_intron, protein_coding, processed_transcript	uc011lln.2	nonsynonymous SNV	exon4	c.T1349G	p.V450G	FSMSTQLTIHQRVHTGERPYKCNEC	FSMSTQLTIHQRGHTGERPYKCNEC	9.0	3.0	-	-	4245_8:146068129-146068129 T>G_FSMSTQLTIHQRGHTGERPYKCNEC	0.0
3:194365391-194365391 T>C	1.0	4320	COLORECTAL	-	-	-	-	LSG1	ENST00000265245,p.M570V|NM_018385,p.M570V|uc003fui.3,p.M570V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003fui.3	nonsynonymous SNV	exon13	c.A1708G	p.M570V	FQHQHQRLLENKMNSDEIKMQLGRN	FQHQHQRLLENKVNSDEIKMQLGRN	9.0	8.0	-	-	4320_3:194365391-194365391 T>C_FQHQHQRLLENKVNSDEIKMQLGRN	0.0
4:173150896-173150896 G>T	0.0	4266	COLORECTAL	-	-	-	-	GALNTL6	uc003isv.3,p.Q76H|ENST00000508122,p.Q59H|NM_001034845,p.Q76H|ENST00000506823,p.Q76H	protein_coding, processed_transcript	uc003isv.3	nonsynonymous SNV	exon3	c.G228T	p.Q76H	LRRKDWHDYESIQKEAMRSGKGEHG	LRRKDWHDYESIHKEAMRSGKGEHG	1.0	6.0	-	-	4266_4:173150896-173150896 G>T_LRRKDWHDYESIHKEAMRSGKGEHG	0.0
8:89209493-89209493 T>C	0.0	4284	COLORECTAL	-	-	-	-	MMP16	NM_005941,p.R59G|ENST00000286614,p.R59G|ENST00000522726,p.R76G|uc003yeb.4,p.R59G	retained_intron, protein_coding, processed_transcript	uc003yeb.4	nonsynonymous SNV	exon2	c.A175G	p.R59G	LQKYGYLPPTDPRMSVLRSAETMQS	LQKYGYLPPTDPGMSVLRSAETMQS	5.0	4.0	-	-	4284_8:89209493-89209493 T>C_LQKYGYLPPTDPGMSVLRSAETMQS	0.0
16:84229837-84229837 G>A	1.0	4284	COLORECTAL	-	-	ID=COSM1128852;OCCURENCE=1(prostate)	-	ADAD2	uc002fhr.2,p.A463T|ENST00000315906,p.A463T|uc002fhq.2,p.A545T|NM_001145400,p.A463T|NM_139174,p.A545T|ENST00000268624,p.A545T	retained_intron, protein_coding, processed_transcript	uc002fhr.2	nonsynonymous SNV	exon8	c.G1387A	p.A463T	LGPCLPPPYVRTALHLFAGPPVAPS	LGPCLPPPYVRTTLHLFAGPPVAPS	4.0	8.0	-	-	4284_16:84229837-84229837 G>A_LGPCLPPPYVRTTLHLFAGPPVAPS	0.0
7:101845237-101845237 C>T	1.0	3713	MELANOMA	-	-	-	1	CUX1	ENST00000550008,p.S831F|ENST00000292535,p.S887F|NM_181552,p.S887F|uc003uys.4,p.S898F|ENST00000360264,p.S898F|ENST00000549414,p.S865F|uc003uyx.4,p.S887F|ENST00000546411,p.S785F|ENST00000556210,p.S729F|NM_001202543,p.S898F	retained_intron, protein_coding, processed_transcript	uc003uyx.4	nonsynonymous SNV	exon18	c.C2660T	p.S887F	SSEYWKEWPSAESPYSQSSELSLTG	SSEYWKEWPSAEFPYSQSSELSLTG	8.0	8.0	-	-	3713_7:101845237-101845237 C>T_SSEYWKEWPSAEFPYSQSSELSLTG	0.0
9:125084859-125084859 G>T	1.0	4287	COLORECTAL	-	-	-	-	MRRF	NM_001173512,p.R199M|ENST00000373729,p.R207M|uc011lyr.2,p.R199M|ENST00000344641,p.R251M|uc010mwa.3,p.R251M|ENST00000297908,p.R199M|NM_138777,p.R251M	protein_coding, nonsense_mediated_decay	uc011lyr.2	nonsynonymous SNV	exon6	c.G596T	p.R199M	SQMADDTVAELDRHLAVKTKELLG	SQMADDTVAELDMHLAVKTKELLG	10.0	5.0	CD8	-	4287_9:125084859-125084859 G>T_SQMADDTVAELDMHLAVKTKELLG	1.0
17:26902259-26902259 C>T	0.0	4081	COLORECTAL	-	-	-	-	ALDOC	ENST00000578590,p.R69H|ENST00000581807,p.R30H|uc002hbp.3,p.R69H|ENST00000460201,p.R69H|ENST00000395321,p.R69H|NM_005165,p.R69H|ENST00000584086,p.R69H|ENST00000226253,p.R69H|ENST00000395319,p.R69H|ENST00000435638,p.R69H	retained_intron, protein_coding	uc002hbp.3	nonsynonymous SNV	exon3	c.G206A	p.R69H	RLYRQVLFSADDRVKKCIGGVIFFH	RLYRQVLFSADDHVKKCIGGVIFFH	7.0	4.0	CD8	-	4081_17:26902259-26902259 C>T_RLYRQVLFSADDHVKKCIGGVIFFH	1.0
12:109605753-109605753 G>A	0.0	4235	COLORECTAL	-	-	-	-	ACACB	ENST00000377854,p.R280H|NM_001093,p.R280H|uc001tob.3,p.R280H|ENST00000377848,p.R280H|uc001toc.3,p.R280H|ENST00000544726,p.R78H|ENST00000338432,p.R280H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001toc.3	nonsynonymous SNV	exon3	c.G839A	p.R280H	NGIAAVKCMRSIRRWAYEMFRNERA	NGIAAVKCMRSIHRWAYEMFRNERA	8.0	10.0	-	-	4235_12:109605753-109605753 G>A_NGIAAVKCMRSIHRWAYEMFRNERA	0.0
1:33764612-33764612 T>G	0.0	4320	COLORECTAL	-	-	-	-	ZNF362	NM_152493,p.S410A|ENST00000373428,p.S410A|uc001bxc.1,p.S410A|ENST00000539719,p.S410A	protein_coding, processed_transcript	uc001bxc.1	nonsynonymous SNV	exon9	c.T1228G	p.S410A	HLVSHHSPQRTESPGIPVRISLI	HLVSHHSPQRTEAPGIPVRISLI	7.0	3.0	-	-	4320_1:33764612-33764612 T>G_HLVSHHSPQRTEAPGIPVRISLI	0.0
11:6662587-6662587 G>C	0.0	4246	COLORECTAL	-	-	-	-	DCHS1	uc001mem.1,p.S86R|NM_003737,p.S86R|ENST00000299441,p.S86R	protein_coding	uc001mem.1	nonsynonymous SNV	exon2	c.C258G	p.S86R	APLMYFISAQEGSGVGTDLAIDEHS	APLMYFISAQEGRGVGTDLAIDEHS	4.0	4.0	-	-	4246_11:6662587-6662587 G>C_APLMYFISAQEGRGVGTDLAIDEHS	0.0
11:92577568-92577568 A>C	0.0	4213	COLORECTAL	-	-	-	2	FAT3	NM_001008781,p.T3679P|ENST00000298047,p.T3679P|ENST00000533797,p.T14P|ENST00000409404,p.T3679P|uc001pdi.4,p.T119P|uc001pdj.4,p.T3679P|ENST00000525166,p.T3529P	retained_intron, protein_coding, processed_transcript	uc001pdj.4	nonsynonymous SNV	exon18	c.A11035C	p.T3679P	HGFRRTLRNAVLTQKQDSLRIISIQ	HGFRRTLRNAVLPQKQDSLRIISIQ	4.0	4.0	-	-	4213_11:92577568-92577568 A>C_HGFRRTLRNAVLPQKQDSLRIISIQ	0.0
20:15412056-15412056 C>T	1.0	2556	MELANOMA	-	-	-	-	MACROD2	ENST00000310348,p.P183S|ENST00000217246,p.P183S|NM_080676,p.P183S|uc002wou.3,p.P183S|uc002wot.3,p.P183S	protein_coding, processed_transcript	uc002wou.3	nonsynonymous SNV	exon7	c.C547T	p.P183S	LVKENNIRSVAFPCISTGIYGFPNE	LVKENNIRSVAFSCISTGIYGFPNE	5.0	6.0	-	-	2556_20:15412056-15412056 C>T_LVKENNIRSVAFSCISTGIYGFPNE	0.0
19:51984835-51984835 C>T	0.0	4259	COLORECTAL	-	-	-	-	CEACAM18	uc002pwv.1,p.R258C|ENST00000396477,p.R197C|NM_001278392,p.R197C|ENST00000451626,p.R258C	protein_coding	uc002pwv.1	nonsynonymous SNV	exon4	c.C772T	p.R258C	PDGKTLVILRVSRYDRTIQCMIESF	PDGKTLVILRVSCYDRTIQCMIESF	6.0	9.0	-	-	4259_19:51984835-51984835 C>T_PDGKTLVILRVSCYDRTIQCMIESF	0.0
17:48272838-48272838 C>T	1.0	3713	MELANOMA	-	-	-	1	COL1A1	NM_000088,p.G386E|ENST00000225964,p.G386E|uc002iqm.3,p.G386E	retained_intron, protein_coding	uc002iqm.3	nonsynonymous SNV	exon18	c.G1157A	p.G386E	GPPGPAGAAGPAGNPGADGQPGAKG	GPPGPAGAAGPAENPGADGQPGAKG	10.0	3.0	-	-	3713_17:48272838-48272838 C>T_GPPGPAGAAGPAENPGADGQPGAKG	0.0
7:44047357-44047357 G>A	0.0	4245	COLORECTAL	-	rs62458722	-	-	SPDYE1	ENST00000258704,p.R334H|NM_175064,p.R334H|uc003tjf.3,p.R334H	protein_coding	uc003tjf.3	nonsynonymous SNV	exon6	c.G1001A	p.R334H	DPEHWVWARDRARLS	DPEHWVWARDRAHLS	2.0	6.0	-	-	4245_7:44047357-44047357 G>A_DPEHWVWARDRAHLS	0.0
8:135490781-135490781 C>T	1.0	3784	MELANOMA	-	-	-	-	ZFAT	uc010mej.3,p.E1164K|NM_001289394,p.E1214K|uc010meh.3,p.E1128K|NM_001167583,p.E1214K|NM_001029939,p.E1214K|uc003yup.3,p.E1226K|uc003yuq.3,p.E1214K|ENST00000520356,p.E1128K|ENST00000521673,p.E146K|ENST00000520214,p.E1214K|uc003yun.3,p.E1214K|ENST00000523399,p.E1164K|ENST00000377838,p.E1226K|NM_001174157,p.E1164K|NM_001174158,p.E1128K|ENST00000520727,p.E1214K|NM_020863,p.E1226K|uc011ljj.2,p.E345K|uc003yuo.3,p.E1214K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ljj.2	nonsynonymous SNV	exon6	c.G1033A	p.E345K	GGEASEFIVYVQEAMQPVEEQAVEQ	GGEASEFIVYVQKAMQPVEEQAVEQ	6.0	3.0	-	-	3784_8:135490781-135490781 C>T_GGEASEFIVYVQKAMQPVEEQAVEQ	0.0
12:112630923-112630923 G>A	1.0	3998	MELANOMA	-	-	-	-	HECTD4	NM_001109662,p.P2876S|ENST00000377560,p.P2838S|ENST00000430131,p.P2588S|ENST00000550722,p.P2864S|uc021reb.1,p.P2876S	retained_intron, protein_coding, processed_transcript	uc021reb.1	nonsynonymous SNV	exon58	c.C8626T	p.P2876S	ISESKVNMDVNFPGAAFVVVSCKES	ISESKVNMDVNFSGAAFVVVSCKES	9.0	5.0	-	-	3998_12:112630923-112630923 G>A_ISESKVNMDVNFSGAAFVVVSCKES	0.0
7:75192367-75192367 A>C	0.0	4246	COLORECTAL	-	-	-	1	HIP1	uc003uds.2,p.F298V|ENST00000434438,p.F298V|uc011kfz.2,p.F298V|NM_001243198,p.F298V|ENST00000336926,p.F298V|NM_005338,p.F298V	retained_intron, protein_coding, processed_transcript	uc011kfz.2	nonsynonymous SNV	exon11	c.T892G	p.F298V	IQIPQLPENPPNFLRASALSEHISP	IQIPQLPENPPNVLRASALSEHISP	7.0	5.0	-	-	4246_7:75192367-75192367 A>C_IQIPQLPENPPNVLRASALSEHISP	0.0
3:48611721-48611721 C>T	0.0	3919	MELANOMA	-	-	-	-	COL7A1	ENST00000328333,p.G2159S|NM_000094,p.G2159S|ENST00000454817,p.G2127S|uc003ctz.2,p.G2159S	retained_intron, protein_coding, processed_transcript	uc003ctz.2	nonsynonymous SNV	exon79	c.G6475A	p.G2159S	GQDGNPGLPGERGMAGPEGKPGLQG	GQDGNPGLPGERSMAGPEGKPGLQG	3.0	5.0	-	-	3919_3:48611721-48611721 C>T_GQDGNPGLPGERSMAGPEGKPGLQG	0.0
12:56428757-56428757 ->TGCGGGG	0.0	4266	COLORECTAL	-	-	-	-	IKZF4	uc001sjb.1,p.V467fs|ENST00000547791,p.V422fs|uc009zoi.1,p.V422fs|NM_022465,p.V467fs|ENST00000431367,p.V365fs|uc010sqa.1,p.V420fs|ENST00000547167,p.V467fs|ENST00000262032,p.V467fs|uc001sjc.1,p.V467fs|uc001sjd.1,p.V365fs|uc001sje.1,p.V426fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010sqa.1	frameshift insertion	exon7	c.1259_1260insTGCGGGG	p.V420fs	DSTDTESNHEDRVAGVVSLPQGPPP	DSTDTESNHEDRVAGCGGGIPPSGSPTPATSHHCGGPAQSCLRQRGPQATGGVIAGHPRPLQGSASGGGREW	4.0	5.0	-	-	4266_12:56428757-56428757 ->TGCGGGG_DSTDTESNHEDRVAGCGGGIPPSGSPTPATSHHCGGPAQSCLRQRGPQATGGVIAGHPRPLQGSASGGGREW	0.0
8:77767640-77767640 G>A	0.0	4301	MELANOMA	-	-	-	-	ZFHX4	ENST00000518282,p.G2802E|uc003yaw.1,p.G2783E|ENST00000521891,p.G2828E|ENST00000455469,p.G2783E|uc003yau.2,p.G2828E|NM_024721,p.G2828E|ENST00000050961,p.G2783E	retained_intron, protein_coding, nonsense_mediated_decay	uc003yaw.1	nonsynonymous SNV	exon9	c.G8348A	p.G2783E	GDEGNTEMESTTGSSGDVKPALSPK	GDEGNTEMESTTESSGDVKPALSPK	5.0	9.0	-	-	4301_8:77767640-77767640 G>A_GDEGNTEMESTTESSGDVKPALSPK	0.0
8:70553043-70553043 G>A	1.0	3466	MELANOMA	-	-	-	-	SULF1	uc010lza.1,p.G851E|uc003xyd.2,p.G851E|ENST00000402687,p.G851E|NM_015170,p.G851E|uc003xyg.2,p.G851E|ENST00000458141,p.G851E|uc003xyf.2,p.G851E|ENST00000419716,p.G851E|NM_001128204,p.G851E|uc003xye.2,p.G851E|NM_001128206,p.G851E|NM_001128205,p.G851E|ENST00000260128,p.G851E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010lza.1	nonsynonymous SNV	exon22	c.G2552A	p.G851E	KQCNPRPKNLDVGNKDGGSYDLHRG	KQCNPRPKNLDVENKDGGSYDLHRG	10.0	9.0	-	-	3466_8:70553043-70553043 G>A_KQCNPRPKNLDVENKDGGSYDLHRG	0.0
1:36031058-36031058 C>T	1.0	3713	MELANOMA	-	-	-	-	NCDN	ENST00000373253,p.R645C|ENST00000356090,p.R662C|NM_001014839,p.R662C|NM_001014841,p.R645C|NM_014284,p.R662C|ENST00000373243,p.R662C|uc001bzb.3,p.R662C|uc001bza.3,p.R662C|uc001bzc.3,p.R645C	protein_coding, processed_transcript	uc001bzc.3	nonsynonymous SNV	exon7	c.C1933T	p.R645C	LLPWLAPAALRSRWPQELLQLLGSV	LLPWLAPAALRSCWPQELLQLLGSV	9.0	7.0	-	-	3713_1:36031058-36031058 C>T_LLPWLAPAALRSCWPQELLQLLGSV	0.0
9:5968768-5968768 G>A	1.0	3879	MELANOMA	-	-	-	-	KIAA2026	uc003zjq.4,p.P488L|ENST00000513355,p.P421L|NM_001017969,p.P488L|ENST00000381461,p.P488L|ENST00000399933,p.P488L	protein_coding, processed_transcript, nonsense_mediated_decay	uc003zjq.4	nonsynonymous SNV	exon3	c.C1463T	p.P488L	FCGADVRIYKQRPFQAPEFPIPPIK	FCGADVRIYKQRLFQAPEFPIPPIK	8.0	6.0	-	-	3879_9:5968768-5968768 G>A_FCGADVRIYKQRLFQAPEFPIPPIK	0.0
16:58616794-58616794 G>A	1.0	2359	MELANOMA	-	-	-	-	CNOT1	NM_001265612,p.P316L|uc002enx.4,p.P316L|uc002env.4,p.P316L|uc002enu.5,p.P316L|ENST00000567188,p.P316L|NM_016284,p.P316L|NM_206999,p.P316L|ENST00000441024,p.P316L|ENST00000317147,p.P316L|ENST00000569240,p.P316L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002enx.4	nonsynonymous SNV	exon10	c.C947T	p.P316L	LTDGIPLQSISAPGSGIWSDGKDKS	LTDGIPLQSISALGSGIWSDGKDKS	10.0	7.0	-	-	2359_16:58616794-58616794 G>A_LTDGIPLQSISALGSGIWSDGKDKS	0.0
5:158588338-158588338 G>A	1.0	3713	MELANOMA	-	-	-	-	RNF145	uc010jiq.2,p.S551L|NM_001199380,p.S551L|uc003lxp.3,p.S521L|NM_001199383,p.S521L|ENST00000521606,p.S538L|NM_144726,p.S549L|ENST00000520638,p.S535L|ENST00000518802,p.S551L|uc011ddy.2,p.S535L|NM_001199381,p.S538L|ENST00000424310,p.S521L|uc003lxo.2,p.S549L|ENST00000274542,p.S549L|uc011ddz.2,p.S538L|NM_001199382,p.S535L|ENST00000519865,p.S521L	retained_intron, protein_coding, processed_transcript	uc011ddz.2	nonsynonymous SNV	exon10	c.C1613T	p.S538L	FLLRRDAVNKIKSLPIATKEQLEKH	FLLRRDAVNKIKLLPIATKEQLEKH	10.0	5.0	-	-	3713_5:158588338-158588338 G>A_FLLRRDAVNKIKLLPIATKEQLEKH	0.0
12:95461111-95461111 C>T	1.0	4244	COLORECTAL	-	-	-	-	NR2C1	NM_003297,p.G17E|uc001tdn.4,p.G17E|ENST00000333003,p.G17E|ENST00000330677,p.G17E|ENST00000393101,p.G17E|uc010suu.1,p.G17E|NM_001032287,p.G17E|uc001tdm.5,p.G17E|uc001tdo.4,p.G17E|NM_001127362,p.G17E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010suu.1	nonsynonymous SNV	exon1	c.G50A	p.G17E	EEIAHQIIEQQMGEIVTEQQTGQKI	EEIAHQIIEQQMEEIVTEQQTGQKI	9.0	6.0	-	-	4244_12:95461111-95461111 C>T_EEIAHQIIEQQMEEIVTEQQTGQKI	0.0
17:42476350-42476350 C>T	1.0	4275	COLORECTAL	-	-	-	-	GPATCH8	NM_001002909,p.R1032H|uc002igw.2,p.R1032H|uc002igv.2,p.R954H|uc010wiz.2,p.R954H|ENST00000591680,p.R1032H|ENST00000434000,p.R954H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wiz.2	nonsynonymous SNV	exon9	c.G2861A	p.R954H	SGRRDFIRSKIYRSQSPHYFRSGRG	SGRRDFIRSKIYHSQSPHYFRSGRG	10.0	5.0	CD8	-	4275_17:42476350-42476350 C>T_SGRRDFIRSKIYHSQSPHYFRSGRG	1.0
6:132910728-132910728 A>C	0.0	4110	BILE DUCT	-	-	-	-	TAAR5	NM_003967,p.I33S|uc003qdk.2,p.I33S|ENST00000258034,p.I33S	protein_coding	uc003qdk.2	nonsynonymous SNV	exon1	c.T98G	p.I33S	NGSCPRTVHTLGIQLVIYLACAAGM	NGSCPRTVHTLGSQLVIYLACAAGM	1.0	9.0	-	-	4110_6:132910728-132910728 A>C_NGSCPRTVHTLGSQLVIYLACAAGM	0.0
1:111737203-111737203 A>G	1.0	4320	COLORECTAL	-	-	-	-	DENND2D	NM_024901,p.L264P|ENST00000357640,p.L264P|NM_001271833,p.L261P|uc001eal.2,p.L261P|ENST00000369752,p.L261P|uc001eak.2,p.L264P	protein_coding, processed_transcript	uc001eal.2	nonsynonymous SNV	exon7	c.T782C	p.L261P	VLERKIIFLAEGLSTLSQCIHAAAA	VLERKIIFLAEGPSTLSQCIHAAAA	7.0	6.0	CD8	-	4320_1:111737203-111737203 A>G_VLERKIIFLAEGPSTLSQCIHAAAA	1.0
5:16703173-16703173 C>A	1.0	4317	COLORECTAL	-	-	-	-	MYO10	uc011cne.2,p.A148S|uc011cnd.2,p.A148S|uc010itx.3,p.A414S|ENST00000515803,p.A130S|ENST00000513610,p.A791S|ENST00000513882,p.A802S|ENST00000274203,p.A148S|uc003jft.4,p.A791S|NM_012334,p.A791S|ENST00000427430,p.A148S|ENST00000505695,p.A130S	retained_intron, protein_coding, processed_transcript	uc011cne.2	nonsynonymous SNV	exon5	c.G442T	p.A148S	FLLRRRFLHLKKAAIVFQKQLRGQI	FLLRRRFLHLKKSAIVFQKQLRGQI	10.0	7.0	-	-	4317_5:16703173-16703173 C>A_FLLRRRFLHLKKSAIVFQKQLRGQI	0.0
12:49742869-49742869 G>A	1.0	3713	MELANOMA	-	-	-	-	DNAJC22	uc001rua.3,p.V72M|NM_024902,p.V72M|ENST00000549441,p.V72M|ENST00000395069,p.V72M|uc001rub.3,p.V72M	retained_intron, protein_coding, processed_transcript	uc001rub.3	nonsynonymous SNV	exon3	c.G214A	p.V72M	NRAQGQRQSPRGVTPPLSPIRFAAQ	NRAQGQRQSPRGMTPPLSPIRFAAQ	2.0	4.0	-	-	3713_12:49742869-49742869 G>A_NRAQGQRQSPRGMTPPLSPIRFAAQ	0.0
6:53761323-53761326 GAGA>-	1.0	4237	NSCLC	-	-	-	-	LRRC1	ENST00000487251,p.L158fs|NM_018214,p.L158fs|uc003pcd.1,p.L158fs|ENST00000370888,p.L158fs	protein_coding, processed_transcript, nonsense_mediated_decay	uc003pcd.1	frameshift deletion	exon5	c.474_477del	p.L158fs	NIGNLYNLASLELRENLLTYLPDSLT	NIGNLYNLASLELRIFLHIFLTLLPSCED	7.0	9.0	-	-	4237_6:53761323-53761326 GAGA>-_NIGNLYNLASLELRIFLHIFLTLLPSCED	0.0
20:40117133-40117133 C>G	1.0	4240	BREAST	-	-	-	-	CHD6	ENST00000373233,p.D598H|uc002xka.1,p.D598H|uc002xkd.2,p.D576H|NM_032221,p.D598H	protein_coding, processed_transcript	uc002xkd.2	nonsynonymous SNV	exon12	c.G1726C	p.D576H	ELKKIHWSCVIIDEAHRLKNRNCKL	ELKKIHWSCVIIHEAHRLKNRNCKL	10.0	9.0	-	-	4240_20:40117133-40117133 C>G_ELKKIHWSCVIIHEAHRLKNRNCKL	0.0
19:9046046-9046046 A>T	0.0	4259	COLORECTAL	-	-	-	2	MUC16	uc002mkp.3,p.I11862N|ENST00000397910,p.I11862N|NM_024690,p.I11862N	protein_coding, processed_transcript, nonsense_mediated_decay	uc002mkp.3	nonsynonymous SNV	exon5	c.T35585A	p.I11862N	LSTHPGTETSTMIPTSTLSLGLLET	LSTHPGTETSTMNPTSTLSLGLLET	4.0	9.0	-	-	4259_19:9046046-9046046 A>T_LSTHPGTETSTMNPTSTLSLGLLET	0.0
11:67817178-67817178 A>G	1.0	4110	BILE DUCT	-	-	-	-	TCIRG1	uc001one.3,p.I646V|NM_006053,p.I430V|NM_006019,p.I646V|ENST00000532635,p.I430V|uc001ong.3,p.I430V|ENST00000265686,p.I646V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ong.3	nonsynonymous SNV	exon11	c.A1288G	p.I430V	ATLVVLALAMVPILLLGTPLHLLHR	ATLVVLALAMVPVLLLGTPLHLLHR	9.0	6.0	-	-	4110_11:67817178-67817178 A>G_ATLVVLALAMVPVLLLGTPLHLLHR	0.0
13:108518356-108518356 G>A	0.0	4316	COLORECTAL	-	-	-	-	FAM155A	NM_001080396,p.R197W|uc001vql.3,p.R197W|ENST00000375915,p.R197W	protein_coding	uc001vql.3	nonsynonymous SNV	exon1	c.C589T	p.R197W	ENADAVCARNWSRGAAGGDGQEVRS	ENADAVCARNWSWGAAGGDGQEVRS	4.0	8.0	-	-	4316_13:108518356-108518356 G>A_ENADAVCARNWSWGAAGGDGQEVRS	0.0
16:67195814-67195816 CGC>-	1.0	4078	GASTRIC	-	-	-	-	FBXL8	ENST00000517382,p.42_43del	protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000517382	nonframeshift deletion	exon2	c.126_128del	p.42_43del	RVCRAWAAAATCSAVWHDTKIRRPT	RVCRAWAAAATCSVWHDTKIRRPTR	5.0	5.0	-	-	4078_16:67195814-67195816 CGC>-_RVCRAWAAAATCSVWHDTKIRRPTR	0.0
7:143078702-143078702 C>T	1.0	4244	COLORECTAL	-	-	-	-	ZYX	uc011kte.2,p.S13L|ENST00000322764,p.S13L|NM_001010972,p.S13L|NM_003461,p.S13L|uc003wcw.3,p.S13L|ENST00000457235,p.S13L|uc003wcx.3,p.S13L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kte.2	nonsynonymous SNV	exon1	c.C38T	p.S13L	MAAPRPSPAISVSVSAPAFYAPQKK	MAAPRPSPAISVLVSAPAFYAPQKK	10.0	1.0	-	-	4244_7:143078702-143078702 C>T_MAAPRPSPAISVLVSAPAFYAPQKK	0.0
15:43892290-43892290 T>C	0.0	4237	NSCLC	-	-	-	-	STRC	uc001zsf.3,p.I1703V|ENST00000450892,p.I1703V|ENST00000541030,p.I930V|uc010bdl.3,p.I930V|uc001zse.3,p.I221V|NM_153700,p.I1703V	retained_intron, protein_coding, nonsense_mediated_decay	uc010bdl.3	nonsynonymous SNV	exon27	c.A2788G	p.I930V	IPPPKFAVVFSPIQLSSLTSAQAVA	IPPPKFAVVFSPVQLSSLTSAQAVA	4.0	7.0	-	-	4237_15:43892290-43892290 T>C_IPPPKFAVVFSPVQLSSLTSAQAVA	0.0
15:40750818-40750818 G>A	1.0	4186	BREAST	-	-	-	-	BAHD1	NM_014952,p.R52H|uc001zlu.2,p.R52H|uc010bbp.1,p.R52H|NM_001301132,p.R52H|ENST00000416165,p.R52H|ENST00000561234,p.R52H|uc001zlv.2,p.R52H|ENST00000560846,p.R52H|uc001zlt.2,p.R52H	retained_intron, protein_coding	uc010bbp.1	nonsynonymous SNV	exon2	c.G155A	p.R52H	GMPESPGHLTGRRKNYPLRKRPLVP	GMPESPGHLTGRHKNYPLRKRPLVP	5.0	6.0	-	-	4186_15:40750818-40750818 G>A_GMPESPGHLTGRHKNYPLRKRPLVP	0.0
11:72468901-72468901 C>T	1.0	4252	COLORECTAL	-	-	ID=COSM1475880;OCCURENCE=1(breast)	-	STARD10	uc001otb.3,p.R163Q|ENST00000543304,p.R163Q|ENST00000537351,p.R70Q|ENST00000334805,p.R163Q|ENST00000545082,p.R134Q|ENST00000538536,p.R117Q|ENST00000536728,p.R94Q|NM_006645,p.R163Q|ENST00000537947,p.R163Q|uc001osz.4,p.R163Q|uc001ota.3,p.R117Q|ENST00000542989,p.R163Q|ENST00000544767,p.R94Q|uc001osy.3,p.R163Q	retained_intron, protein_coding, processed_transcript, TEC	uc001otb.3	nonsynonymous SNV	exon5	c.G488A	p.R163Q	KHPKYPPRKDLVRAVSIQTGYLIQS	KHPKYPPRKDLVQAVSIQTGYLIQS	10.0	8.0	-	-	4252_11:72468901-72468901 C>T_KHPKYPPRKDLVQAVSIQTGYLIQS	0.0
20:50406698-50406698 C>T	0.0	4301	MELANOMA	-	-	-	1	SALL4	uc002xwh.4,p.R775Q|ENST00000217086,p.R775Q|NM_020436,p.R775Q	protein_coding, processed_transcript	uc002xwh.4	nonsynonymous SNV	exon2	c.G2324A	p.R775Q	SSSLMGDQEYQSRSPDILETTSFQA	SSSLMGDQEYQSQSPDILETTSFQA	5.0	6.0	-	-	4301_20:50406698-50406698 C>T_SSSLMGDQEYQSQSPDILETTSFQA	0.0
12:71029509-71029509 C>T	1.0	3713	MELANOMA	-	-	-	1	PTPRB	ENST00000551525,p.M130I|uc001swc.4,p.M131I|ENST00000550358,p.M131I|ENST00000334414,p.M131I|uc001swd.4,p.M130I|NM_001109754,p.M131I|uc001swa.4,p.M131I|uc001swe.3,p.M131I	retained_intron, protein_coding, processed_transcript	uc001swe.3	nonsynonymous SNV	exon2	c.G393A	p.M131I	VVKKARKYLHSWMKIDVNKEGKLVN	VVKKARKYLHSWIKIDVNKEGKLVN	2.0	6.0	-	-	3713_12:71029509-71029509 C>T_VVKKARKYLHSWIKIDVNKEGKLVN	0.0
6:43190311-43190311 G>A	1.0	4244	COLORECTAL	-	-	-	-	CUL9	uc010jyk.3,p.E1474K|ENST00000372647,p.E2294K|uc003ouk.3,p.E2322K|ENST00000252050,p.E2322K|uc003oun.3,p.E117K|ENST00000354495,p.E2212K|NM_015089,p.E2322K|uc003oul.3,p.E2294K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jyk.3	nonsynonymous SNV	exon36	c.G4420A	p.E1474K	AVNLRNRVSAIHEVPPPRSFTFLND	AVNLRNRVSAIHKVPPPRSFTFLND	9.0	3.0	-	-	4244_6:43190311-43190311 G>A_AVNLRNRVSAIHKVPPPRSFTFLND	0.0
2:120194523-120194523 G>A	0.0	4326	BREAST	0.0005	-	-	-	TMEM37	ENST00000409826,p.R39Q|uc002tly.3,p.R27Q|ENST00000306406,p.R27Q|NM_183240,p.R27Q	protein_coding, processed_transcript	uc002tly.3	nonsynonymous SNV	exon2	c.G80A	p.R27Q	RQPRRSFFESFIRTLIITCVALAVV	RQPRRSFFESFIQTLIITCVALAVV	5.0	7.0	-	-	4326_2:120194523-120194523 G>A_RQPRRSFFESFIQTLIITCVALAVV	0.0
2:231222552-231222552 G>A	1.0	3713	MELANOMA	-	-	-	-	SP140L	NM_138402,p.G47E|ENST00000243810,p.G47E|ENST00000415673,p.G47E|ENST00000444636,p.G47E|ENST00000396563,p.G47E|uc010fxm.1,p.G47E	retained_intron, protein_coding	uc010fxm.1	nonsynonymous SNV	exon3	c.G140A	p.G47E	QRLFTEDQDVDEGLVYDTVFKHFKR	QRLFTEDQDVDEELVYDTVFKHFKR	7.0	4.0	-	-	3713_2:231222552-231222552 G>A_QRLFTEDQDVDEELVYDTVFKHFKR	0.0
X:69176881-69176881 C>T	0.0	2556	MELANOMA	-	-	-	-	EDA	ENST00000374553,p.A134V|uc004dxr.3,p.A134V|NM_001005612,p.A134V|NM_001005609,p.A134V|uc004dxs.3,p.A134V|uc004dxq.1,p.A134V|ENST00000374552,p.A134V|ENST00000524573,p.A134V|NM_001399,p.A134V|uc011mpj.2,p.A134V	retained_intron, protein_coding, processed_transcript	uc011mpj.2	nonsynonymous SNV	exon2	c.C401T	p.A134V	ALHSDSQDGHQMALLNFFFPDEKPY	ALHSDSQDGHQMVLLNFFFPDEKPY	3.0	8.0	-	-	2556_X:69176881-69176881 C>T_ALHSDSQDGHQMVLLNFFFPDEKPY	0.0
1:33795685-33795685 T>C	1.0	3678	MELANOMA	-	-	-	-	PHC2	ENST00000373416,p.D176G|NM_198040,p.D711G|uc001bxg.1,p.D711G|NM_004427,p.D176G|ENST00000257118,p.D711G|ENST00000373422,p.D317G|uc001bxh.1,p.D683G|ENST00000373418,p.D176G|uc001bxf.1,p.D126G|ENST00000419414,p.D712G|uc009vuh.1,p.D712G|ENST00000431992,p.D682G|uc001bxe.1,p.D176G	protein_coding, processed_transcript	uc009vuh.1	nonsynonymous SNV	exon13	c.A2135G	p.D712G	RASKASLPPLTKDTKKQPTGTVPLS	RASKASLPPLTKGTKKQPTGTVPLS	8.0	10.0	-	-	3678_1:33795685-33795685 T>C_RASKASLPPLTKGTKKQPTGTVPLS	0.0
13:41705943-41705943 A>C	1.0	4298	COLORECTAL	-	-	-	-	KBTBD6	uc001uxu.1,p.S235R|ENST00000379485,p.S235R|ENST00000499385,p.S169R|NM_152903,p.S235R	protein_coding	uc001uxu.1	nonsynonymous SNV	exon1	c.T705G	p.S235R	LAVLRLDSLDVESEQTVCHVAVQWL	LAVLRLDSLDVEREQTVCHVAVQWL	6.0	8.0	-	-	4298_13:41705943-41705943 A>C_LAVLRLDSLDVEREQTVCHVAVQWL	0.0
11:125853928-125853928 G>A	1.0	3879	MELANOMA	-	-	-	-	CDON	ENST00000392693,p.S945F|uc009zbw.3,p.S945F|uc001qdb.4,p.S322F|NM_016952,p.S945F|ENST00000531738,p.S322F|NM_001243597,p.S945F|uc001qdc.4,p.S945F|ENST00000263577,p.S945F	retained_intron, protein_coding, nonsense_mediated_decay	uc009zbw.3	nonsynonymous SNV	exon16	c.C2834T	p.S945F	EYPVKDLSTPPNSLGSGGNVGPATS	EYPVKDLSTPPNFLGSGGNVGPATS	8.0	9.0	-	-	3879_11:125853928-125853928 G>A_EYPVKDLSTPPNFLGSGGNVGPATS	0.0
16:75670354-75670354 G>-	1.0	4158	COLORECTAL	-	-	-	-	KARS	ENST00000319410,p.S188fs|ENST00000302445,p.S160fs|ENST00000570215,p.S188fs|uc002fer.3,p.S188fs|uc002feq.3,p.S160fs|NM_001130089,p.S188fs|NM_005548,p.S160fs	retained_intron, protein_coding, nonsense_mediated_decay	uc002fer.3	frameshift deletion	exon5	c.564delC	p.S188fs	RGEGVKLQVMANSRNYKSEEEFIHI	RGEGVKLQVMANSEIINQKKNLFILITNCVGET	10.0	8.0	-	-	4158_16:75670354-75670354 G>-_RGEGVKLQVMANSEIINQKKNLFILITNCVGET	0.0
17:48273536-48273536 T>A	0.0	4287	COLORECTAL	-	-	-	1	COL1A1	ENST00000225964,p.T328S|uc002iqm.3,p.T328S|NM_000088,p.T328S	retained_intron, protein_coding	uc002iqm.3	nonsynonymous SNV	exon15	c.A982T	p.T328S	PGPAGARGNDGATGAAGPPGPTGPA	PGPAGARGNDGASGAAGPPGPTGPA	10.0	8.0	-	-	4287_17:48273536-48273536 T>A_PGPAGARGNDGASGAAGPPGPTGPA	0.0
10:100481584-100481584 C>A	0.0	4158	COLORECTAL	-	-	-	-	HPSE2	uc009xwc.2,p.E262D|uc001kpn.2,p.E262D|NM_021828,p.E262D|ENST00000370552,p.E262D|ENST00000370546,p.E262D|NM_001166246,p.E262D	protein_coding	uc009xwc.2	nonsynonymous SNV	exon5	c.G786T	p.E262D	SKKYNISWELGNEPNNYRTMHGRAV	SKKYNISWELGNDPNNYRTMHGRAV	2.0	7.0	-	-	4158_10:100481584-100481584 C>A_SKKYNISWELGNDPNNYRTMHGRAV	0.0
1:98060628-98060628 T>A	1.0	4129	NSCLC	-	-	-	-	DPYD	uc001drv.3,p.K315N|ENST00000370192,p.K315N|NM_000110,p.K315N	protein_coding, processed_transcript	uc001drv.3	nonsynonymous SNV	exon9	c.A945T	p.K315N	FYTSKDFLPLVAKGSKAGMCACHSP	FYTSKDFLPLVANGSKAGMCACHSP	6.0	7.0	-	-	4129_1:98060628-98060628 T>A_FYTSKDFLPLVANGSKAGMCACHSP	0.0
2:33359928-33359928 G>T	0.0	4129	NSCLC	-	-	ID=COSM1649796,COSM574849;OCCURENCE=1(lung)	-	LTBP1	ENST00000404816,p.G368C|uc021vft.1,p.G368C|uc010ymz.2,p.G42C|uc010yna.2,p.G42C|uc002rov.3,p.G42C|NM_000627,p.G42C|ENST00000418533,p.G42C|ENST00000404525,p.G42C|ENST00000354476,p.G368C|NM_206943,p.G368C|NM_001166264,p.G42C|ENST00000390003,p.G42C|NM_001166265,p.G42C|ENST00000407925,p.G42C|NM_001166266,p.G42C|ENST00000402934,p.G42C|uc002rou.3,p.G42C	protein_coding, processed_transcript	uc021vft.1	nonsynonymous SNV	exon5	c.G1102T	p.G368C	FTPSICKVTCTKGSCQNSCEKGNTT	FTPSICKVTCTKCSCQNSCEKGNTT	8.0	8.0	-	-	4129_2:33359928-33359928 G>T_FTPSICKVTCTKCSCQNSCEKGNTT	0.0
3:112545978-112545978 C>T	0.0	4213	COLORECTAL	-	-	-	-	CD200R1L	ENST00000488794,p.A160T|uc010hqf.1,p.A160T|NM_001199215,p.A160T|ENST00000448932,p.A160T|uc003dzi.1,p.A181T|uc011bhw.1,p.A160T|ENST00000398214,p.A181T|NM_001008784,p.A181T	protein_coding, nonsense_mediated_decay	uc011bhw.1	nonsynonymous SNV	exon6	c.G478A	p.A160T	AQISWIPEGSILATKQEYWGNGTVT	AQISWIPEGSILTTKQEYWGNGTVT	4.0	3.0	-	-	4213_3:112545978-112545978 C>T_AQISWIPEGSILTTKQEYWGNGTVT	0.0
15:62221898-62221898 T>A	0.0	3775	CERVICAL	-	-	ID=COSM1727199,COSM1727200;OCCURENCE=1(liver)	-	VPS13C	ENST00000395898,p.I1987L|uc002agz.3,p.I2030L|ENST00000261517,p.I2030L|NM_001018088,p.I2030L|ENST00000395896,p.I2030L|uc002aha.3,p.I1987L|NM_017684,p.I1987L|ENST00000249837,p.I1987L|NM_020821,p.I2030L|uc002ahb.2,p.I2030L|NM_018080,p.I1987L|uc002ahc.2,p.I1987L	retained_intron, protein_coding, processed_transcript	uc002ahc.2	nonsynonymous SNV	exon49	c.A5959T	p.I1987L	KNDQDNNSSMIDISYKQDKNGSQID	KNDQDNNSSMIDLSYKQDKNGSQID	9.0	3.0	-	-	3775_15:62221898-62221898 T>A_KNDQDNNSSMIDLSYKQDKNGSQID	0.0
3:44607138-44607138 G>A	0.0	4158	COLORECTAL	-	-	-	-	ZKSCAN7	ENST00000418719,p.G195R	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000418719	nonsynonymous SNV	exon3	c.G583A	p.G195R	PPYDPGTHHLPSGDFGYCGI	PPYDPGTHHLPSRDFGYCGI	4.0	5.0	-	-	4158_3:44607138-44607138 G>A_PPYDPGTHHLPSRDFGYCGI	0.0
7:107738946-107738946 C>A	0.0	4245	COLORECTAL	-	-	-	-	LAMB4	ENST00000388781,p.G421V|ENST00000205386,p.G421V|uc010ljo.1,p.G421V|ENST00000388780,p.G421V|ENST00000418464,p.G421V|NM_007356,p.G421V|uc003vey.2,p.G421V|ENST00000414450,p.G421V	retained_intron, protein_coding, processed_transcript	uc010ljo.1	nonsynonymous SNV	exon11	c.G1262T	p.G421V	VSHSDPALGSVAGQCLCKENVEGAK	VSHSDPALGSVAVQCLCKENVEGAK	5.0	2.0	-	-	4245_7:107738946-107738946 C>A_VSHSDPALGSVAVQCLCKENVEGAK	0.0
9:112969753-112969753 G>A	1.0	4317	COLORECTAL	-	-	-	-	C9orf152	NM_001012993,p.P36L|ENST00000400613,p.P36L|uc011lwk.2,p.P36L	protein_coding, processed_transcript	uc011lwk.2	nonsynonymous SNV	exon1	c.C107T	p.P36L	EGSRTQAPGKGPPLSIQFLRAQYEG	EGSRTQAPGKGPLLSIQFLRAQYEG	5.0	7.0	-	-	4317_9:112969753-112969753 G>A_EGSRTQAPGKGPLLSIQFLRAQYEG	0.0
19:6694620-6694621 CT>-	0.0	4240	BREAST	-	-	-	-	C3	NM_000064,p.E992fs|ENST00000245907,p.E992fs|uc002mfm.3,p.E992fs	retained_intron, protein_coding, processed_transcript	uc002mfm.3	frameshift deletion	exon24	c.2975_2976del	p.E992fs	ILLQGTPVAQMTEDAVDAERLKHLI	ILLQGTPVAQMTGCRRRGTAEAPHCDPLGLRGTEHDRHDAHGHRCALPG	10.0	6.0	-	-	4240_19:6694620-6694621 CT>-_ILLQGTPVAQMTGCRRRGTAEAPHCDPLGLRGTEHDRHDAHGHRCALPG	0.0
3:120371485-120371485 G>A	0.0	2591	MELANOMA	-	-	-	-	HGD	NM_000187,p.P99L|uc003edw.3,p.P99L|ENST00000283871,p.P99L|ENST00000476082,p.P58L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003edw.3	nonsynonymous SNV	exon5	c.C296T	p.P99L	EVDPDPNQLRWKPFEIPKASQKKVD	EVDPDPNQLRWKLFEIPKASQKKVD	2.0	8.0	-	-	2591_3:120371485-120371485 G>A_EVDPDPNQLRWKLFEIPKASQKKVD	0.0
2:152727089-152727089 T>C	0.0	4245	COLORECTAL	0.0009	-	-	-	CACNB4	ENST00000397327,p.M172V|uc002txz.3,p.M201V|NM_001005747,p.M185V|ENST00000360283,p.M186V|NM_001005746,p.M201V|NM_001145798,p.M219V|uc002txy.3,p.M185V|uc010fnz.3,p.M219V|ENST00000427385,p.M201V|ENST00000439467,p.M214V|uc002tyb.2,p.M185V|ENST00000534999,p.M185V|uc021vre.1,p.M185V|ENST00000539935,p.M219V|NM_000726,p.M219V|uc002tya.3,p.M219V|ENST00000201943,p.M219V	retained_intron, protein_coding, processed_transcript	uc021vre.1	nonsynonymous SNV	exon7	c.A553G	p.M185V	TEHIPPYDVVPSMRPVVLVGPSLKG	TEHIPPYDVVPSVRPVVLVGPSLKG	3.0	6.0	-	-	4245_2:152727089-152727089 T>C_TEHIPPYDVVPSVRPVVLVGPSLKG	0.0
19:39062903-39062903 G>A	0.0	4329	COLORECTAL	-	-	-	-	RYR1	ENST00000360985,p.C4659Y|ENST00000355481,p.C4659Y|uc002oit.3,p.C4664Y|ENST00000359596,p.C4664Y|NM_000540,p.C4664Y|uc002oiu.3,p.C4659Y|NM_001042723,p.C4659Y	retained_intron, protein_coding, nonsense_mediated_decay	uc002oiu.3	nonsynonymous SNV	exon94	c.G13976A	p.C4659Y	TLVAFLCIIGYNCLKVPLVIFKREK	TLVAFLCIIGYNYLKVPLVIFKREK	3.0	8.0	-	-	4329_19:39062903-39062903 G>A_TLVAFLCIIGYNYLKVPLVIFKREK	0.0
14:24653026-24653026 C>T	1.0	4134	NSCLC	-	-	-	-	IPO4	ENST00000354464,p.E650K|uc001wmz.2,p.E650K|uc001wmt.1,p.E128K|uc001wmv.1,p.E650K|uc001wmu.2,p.E312K|NM_024658,p.E650K|ENST00000560155,p.E650K|uc001wmy.1,p.E514K|uc001wmx.1,p.E514K	retained_intron, protein_coding, nonsense_mediated_decay	uc001wmz.2	nonsynonymous SNV	exon20	c.G1948A	p.E650K	ESDGEEEEELMDEDVEEEDDSEISG	ESDGEEEEELMDKDVEEEDDSEISG	8.0	6.0	-	-	4134_14:24653026-24653026 C>T_ESDGEEEEELMDKDVEEEDDSEISG	0.0
3:14239588-14239588 T>C	1.0	3919	MELANOMA	-	-	-	-	LSM3	ENST00000306024,p.L94P|NM_014463,p.L94P|uc003byn.3,p.L94P	protein_coding	uc003byn.3	nonsynonymous SNV	exon4	c.T281C	p.L94P	IPMLFVRGDGVVLVAPPLRVG	IPMLFVRGDGVVPVAPPLRVG	8.0	2.0	-	-	3919_3:14239588-14239588 T>C_IPMLFVRGDGVVPVAPPLRVG	0.0
13:58206840-58206840 G>A	0.0	4245	COLORECTAL	-	-	-	-	PCDH17	uc010aec.1,p.G54S|uc001vhq.1,p.G54S|ENST00000377918,p.G54S|NM_001040429,p.G54S|ENST00000484979,p.G54S	protein_coding, nonsense_mediated_decay	uc010aec.1	nonsynonymous SNV	exon1	c.G160A	p.G54S	ARLQPGLPPAERGGGGRSKSGSYRV	ARLQPGLPPAERSGGGRSKSGSYRV	7.0	8.0	-	-	4245_13:58206840-58206840 G>A_ARLQPGLPPAERSGGGRSKSGSYRV	0.0
16:815187-815187 T>A	0.0	4320	COLORECTAL	-	-	-	-	MSLN	ENST00000563941,p.F196L|NM_013404,p.F196L|NM_005823,p.F196L|NM_001177355,p.F196L|ENST00000382862,p.F196L|uc002cjt.1,p.F196L|uc010brd.1,p.F195L|ENST00000563651,p.F196L|ENST00000566549,p.F196L|uc002cju.1,p.F196L|uc002cjw.2,p.F196L|ENST00000545450,p.F196L	protein_coding	uc010brd.1	nonsynonymous SNV	exon8	c.T585A	p.F195L	ALGGLACDLPGRFVAESAEVLLPRL	ALGGLACDLPGRLVAESAEVLLPRL	7.0	1.0	-	-	4320_16:815187-815187 T>A_ALGGLACDLPGRLVAESAEVLLPRL	0.0
7:141618713-141618713 T>A	0.0	4278	COLORECTAL	-	-	-	-	OR9A4	uc003vwu.1,p.L13H|ENST00000548136,p.L13H|NM_001001656,p.L13H	protein_coding	uc003vwu.1	nonsynonymous SNV	exon1	c.T38A	p.L13H	MLMNYSSATEFYLLGFPGSEELHHI	MLMNYSSATEFYHLGFPGSEELHHI	3.0	4.0	-	-	4278_7:141618713-141618713 T>A_MLMNYSSATEFYHLGFPGSEELHHI	0.0
1:201780774-201780774 G>A	0.0	4317	COLORECTAL	-	-	-	-	NAV1	ENST00000367297,p.R1606Q|ENST00000367300,p.R1554Q|NM_001167738,p.R1220Q|uc001gwx.3,p.R1220Q|NM_020443,p.R1614Q|ENST00000367296,p.R1614Q|ENST00000367295,p.R1220Q|uc021phi.1,p.R1614Q|ENST00000367302,p.R1567Q|ENST00000295624,p.R1611Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021phi.1	nonsynonymous SNV	exon25	c.G4841A	p.R1614Q	QLYLSNLANQIDRETGIGDVPLVIL	QLYLSNLANQIDQETGIGDVPLVIL	5.0	9.0	-	-	4317_1:201780774-201780774 G>A_QLYLSNLANQIDQETGIGDVPLVIL	0.0
6:69703688-69703688 G>A	0.0	4149	OVARIAN	-	-	ID=COSM230591;OCCURENCE=1(skin)	-	BAI3	uc003pev.4,p.R588Q|uc010kak.3,p.R588Q|NM_001704,p.R588Q|ENST00000370598,p.R588Q	protein_coding	uc010kak.3	nonsynonymous SNV	exon10	c.G1763A	p.R588Q	QHSIKEHLAKGQRMLAGDGMSQVTK	QHSIKEHLAKGQQMLAGDGMSQVTK	2.0	5.0	-	-	4149_6:69703688-69703688 G>A_QHSIKEHLAKGQQMLAGDGMSQVTK	0.0
X:53561113-53561113 G>A	1.0	4287	COLORECTAL	-	-	-	-	HUWE1	NM_031407,p.R4293C|ENST00000262854,p.R4293C|ENST00000342160,p.R4293C|uc004dsp.4,p.R4293C|uc004dsn.4,p.R3101C	protein_coding, processed_transcript	uc004dsp.4	nonsynonymous SNV	exon83	c.C12877T	p.R4293C	FWRALRSFDQADRAKFLQFVTGTSK	FWRALRSFDQADCAKFLQFVTGTSK	10.0	10.0	-	-	4287_X:53561113-53561113 G>A_FWRALRSFDQADCAKFLQFVTGTSK	0.0
7:127670254-127670254 G>T	0.0	4095	COLORECTAL	-	-	-	-	LRRC4	ENST00000494115,p.S65Y|uc003vmk.3,p.S147Y|NM_022143,p.S147Y|ENST00000249363,p.S147Y|uc022akv.1,p.S147Y	protein_coding	uc022akv.1	nonsynonymous SNV	exon1	c.C440A	p.S147Y	LTVIPSGAFEYLSKLRELWLRNNPI	LTVIPSGAFEYLYKLRELWLRNNPI	5.0	7.0	-	-	4095_7:127670254-127670254 G>T_LTVIPSGAFEYLYKLRELWLRNNPI	0.0
12:51236839-51236839 T>G	0.0	4238	COLORECTAL	-	-	-	-	TMPRSS12	uc001rwx.4,p.L31R|NM_182559,p.L31R|uc001rwy.3,p.L31R|ENST00000551456,p.L31R|ENST00000398458,p.L31R	protein_coding	uc001rwy.3	nonsynonymous SNV	exon1	c.T92G	p.L31R	YSDHYSPSGRHRLGPSPEPAASSQQ	YSDHYSPSGRHRRGPSPEPAASSQQ	1.0	1.0	-	-	4238_12:51236839-51236839 T>G_YSDHYSPSGRHRRGPSPEPAASSQQ	0.0
2:196825422-196825422 G>A	0.0	2591	MELANOMA	-	-	ID=COSM718707;OCCURENCE=1(lung)	-	DNAH7	ENST00000312428,p.P818L|uc002utj.4,p.P818L|NM_018897,p.P818L	retained_intron, protein_coding, processed_transcript	uc002utj.4	nonsynonymous SNV	exon18	c.C2453T	p.P818L	GLYKLEKTFHDSPYALAMTKKVRSK	GLYKLEKTFHDSLYALAMTKKVRSK	1.0	8.0	-	-	2591_2:196825422-196825422 G>A_GLYKLEKTFHDSLYALAMTKKVRSK	0.0
13:106119440-106119440 T>G	0.0	3903	MELANOMA	-	-	-	-	DAOA	ENST00000601240,p.F28C|ENST00000375936,p.F28C|ENST00000489237,p.F28C|NM_172370,p.F28C|ENST00000473269,p.F28C|uc001vqb.3,p.F28C	protein_coding, nonsense_mediated_decay	uc001vqb.3	nonsynonymous SNV	exon2	c.T83G	p.F28C	SRYTLGKIYFIGFQRSILLSKSENS	SRYTLGKIYFIGCQRSILLSKSENS	1.0	3.0	-	-	3903_13:106119440-106119440 T>G_SRYTLGKIYFIGCQRSILLSKSENS	0.0
5:89938763-89938763 A>C	0.0	4284	COLORECTAL	-	-	-	-	GPR98	ENST00000405460,p.N820H|NM_032119,p.N820H|uc003kju.3,p.N820H	retained_intron, protein_coding, processed_transcript	uc003kju.3	nonsynonymous SNV	exon13	c.A2458C	p.N820H	QFLHYRVEPRDSNEFYGNTGVLEFK	QFLHYRVEPRDSHEFYGNTGVLEFK	6.0	1.0	-	-	4284_5:89938763-89938763 A>C_QFLHYRVEPRDSHEFYGNTGVLEFK	0.0
2:48738537-48738537 A>T	1.0	4317	COLORECTAL	-	-	-	-	PPP1R21	uc002rwk.3,p.H737L|uc002rwm.3,p.H748L|NM_001193475,p.H706L|ENST00000294952,p.H748L|uc010yok.2,p.H706L|NM_001135629,p.H748L|ENST00000281394,p.H737L|ENST00000449090,p.H706L|uc002rwl.3,p.H702L|NM_152994,p.H737L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yok.2	nonsynonymous SNV	exon19	c.A2117T	p.H706L	RSYEDQLSMMSDHLCSMNETLSKQR	RSYEDQLSMMSDLLCSMNETLSKQR	7.0	1.0	-	-	4317_2:48738537-48738537 A>T_RSYEDQLSMMSDLLCSMNETLSKQR	0.0
19:50832107-50832107 C>G	0.0	4326	BREAST	-	-	-	-	KCNC3	NM_004977,p.G78A|ENST00000376959,p.G78A|ENST00000477616,p.G78A|uc002pru.1,p.G78A	protein_coding	uc002pru.1	nonsynonymous SNV	exon1	c.G233C	p.G78A	AEPCPGLPAAAMGRHGGGGGDSGKI	AEPCPGLPAAAMARHGGGGGDSGKI	6.0	3.0	-	-	4326_19:50832107-50832107 C>G_AEPCPGLPAAAMARHGGGGGDSGKI	0.0
11:118925208-118925208 G>T	1.0	4244	COLORECTAL	-	-	-	-	HYOU1	ENST00000404233,p.Q226K|uc001put.2,p.Q191K|ENST00000543287,p.Q139K|uc001puw.1,p.Q226K|uc010ryu.1,p.Q246K|uc001pux.3,p.Q226K|uc001puu.2,p.Q226K|NM_006389,p.Q226K|NM_001130991,p.Q226K|ENST00000529972,p.Q226K|ENST00000525859,p.Q226K|uc010ryv.1,p.Q115K|ENST00000530473,p.Q226K	retained_intron, protein_coding, nonsense_mediated_decay	uc010ryv.1	nonsynonymous SNV	exon5	c.C343A	p.Q115K	GVFRRKDINTTAQNIMFYDMGSGST	GVFRRKDINTTAKNIMFYDMGSGST	9.0	3.0	-	-	4244_11:118925208-118925208 G>T_GVFRRKDINTTAKNIMFYDMGSGST	0.0
X:47308124-47308124 G>A	1.0	4000	MELANOMA	-	-	-	-	ZNF41	uc004dhs.4,p.H391Y|uc004dhy.4,p.H349Y|NM_153380,p.H349Y|uc004dhx.4,p.H349Y|uc011mlm.2,p.H263Y|uc004dht.4,p.H263Y|ENST00000377065,p.H349Y|ENST00000397050,p.H359Y|ENST00000313116,p.H349Y|NM_007130,p.H349Y|uc004dhu.4,p.H383Y|uc004dhv.4,p.H359Y|uc004dhw.4,p.H351Y	protein_coding, processed_transcript	uc011mlm.2	nonsynonymous SNV	exon4	c.C787T	p.H263Y	TLKSNLITHQKIHTGQKPYKCSECG	TLKSNLITHQKIYTGQKPYKCSECG	7.0	10.0	-	-	4000_X:47308124-47308124 G>A_TLKSNLITHQKIYTGQKPYKCSECG	0.0
6:33383075-33383075 T>G	1.0	4317	COLORECTAL	-	-	-	-	PHF1	NM_024165,p.F435V|uc010jux.3,p.F235V|ENST00000374516,p.F435V|uc003oeh.3,p.F435V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010jux.3	nonsynonymous SNV	exon12	c.T703G	p.F235V	PNQSYQGSSGYNFRPTDARCLPSSP	PNQSYQGSSGYNVRPTDARCLPSSP	9.0	5.0	-	-	4317_6:33383075-33383075 T>G_PNQSYQGSSGYNVRPTDARCLPSSP	0.0
17:57058377-57058377 C>G	0.0	4298	COLORECTAL	-	-	-	-	PPM1E	ENST00000308249,p.S751R|uc002iwx.4,p.S751R|NM_014906,p.S751R|uc010ddd.4,p.S514R	protein_coding	uc010ddd.4	nonsynonymous SNV	exon6	c.C1542G	p.S514R	KTHDIPCPDLPWSYKIE	KTHDIPCPDLPWRYKIE	3.0	5.0	-	-	4298_17:57058377-57058377 C>G_KTHDIPCPDLPWRYKIE	0.0
18:52555297-52555297 G>A	1.0	3713	MELANOMA	-	-	-	-	RAB27B	ENST00000262094,p.D139N|uc002lfr.3,p.D139N|NM_004163,p.D139N	protein_coding, processed_transcript	uc002lfr.3	nonsynonymous SNV	exon5	c.G415A	p.D139N	DIVLIGNKADLPDQREVNERQAREL	DIVLIGNKADLPNQREVNERQAREL	1.0	7.0	-	-	3713_18:52555297-52555297 G>A_DIVLIGNKADLPNQREVNERQAREL	0.0
7:87529601-87529601 C>T	1.0	3784	MELANOMA	-	-	-	-	DBF4	ENST00000413643,p.P229S	retained_intron, protein_coding, nonsense_mediated_decay	ENST00000413643	nonsynonymous SNV	exon9	c.C685T	p.P229S	KPFVKVEDMSQSPAVHLM	KPFVKVEDMSQSSAVHLM	8.0	5.0	-	-	3784_7:87529601-87529601 C>T_KPFVKVEDMSQSSAVHLM	0.0
14:62016407-62016407 C>T	1.0	2369	MELANOMA	-	-	-	-	PRKCH	ENST00000332981,p.S637F|ENST00000555082,p.S476F|uc010tsa.2,p.S476F|NM_006255,p.S637F|uc010tsb.2,p.S205F|uc001xfn.3,p.S637F	protein_coding, processed_transcript	uc010tsb.2	nonsynonymous SNV	exon6	c.C614T	p.S205F	RQIEPPFRPRIKSREDVSNFDPDFI	RQIEPPFRPRIKFREDVSNFDPDFI	7.0	2.0	-	-	2369_14:62016407-62016407 C>T_RQIEPPFRPRIKFREDVSNFDPDFI	0.0
19:8389421-8389421 C>T	0.0	4189	MELANOMA	-	-	-	-	KANK3	NM_198471,p.S765N|ENST00000593649,p.S765N|uc010dwa.3,p.S765N|ENST00000330915,p.S765N	retained_intron, protein_coding	uc010dwa.3	nonsynonymous SNV	exon10	c.G2294A	p.S765N	GCDPAILDNEGTSALAIALEAEQDE	GCDPAILDNEGTNALAIALEAEQDE	4.0	10.0	-	-	4189_19:8389421-8389421 C>T_GCDPAILDNEGTNALAIALEAEQDE	0.0
2:152132127-152132127 G>A	1.0	4180	BREAST	-	-	-	-	NMI	ENST00000243346,p.R169C|uc002txi.2,p.R169C|NM_004688,p.R169C	retained_intron, protein_coding	uc002txi.2	nonsynonymous SNV	exon6	c.C505T	p.R169C	MKINVTEIPDTLREDQMRDKLELSF	MKINVTEIPDTLCEDQMRDKLELSF	10.0	6.0	-	-	4180_2:152132127-152132127 G>A_MKINVTEIPDTLCEDQMRDKLELSF	0.0
17:42824510-42824510 A>C	0.0	4320	COLORECTAL	-	-	-	-	DBF4B	NM_145663,p.K297T|ENST00000315005,p.K297T|ENST00000393547,p.K297T|uc010wjc.2,p.K297T|NM_025104,p.K297T|uc002ihe.3,p.K111T|uc002ihf.3,p.K297T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wjc.2	nonsynonymous SNV	exon11	c.A890C	p.K297T	SPRSAAHTMPRRKKGYCECCQEAFE	SPRSAAHTMPRRTKGYCECCQEAFE	6.0	4.0	-	-	4320_17:42824510-42824510 A>C_SPRSAAHTMPRRTKGYCECCQEAFE	0.0
2:113498584-113498584 C>T	1.0	3879	MELANOMA	-	-	-	-	CKAP2L	NM_152515,p.G608E|ENST00000302450,p.G608E|uc002tie.2,p.G608E|ENST00000541405,p.G443E|uc002tif.2,p.G197E|uc010yxp.1,p.G443E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yxp.1	nonsynonymous SNV	exon8	c.G1328A	p.G443E	LNILQDSNRTTEGITSDSLVAETSI	LNILQDSNRTTEEITSDSLVAETSI	5.0	6.0	-	-	3879_2:113498584-113498584 C>T_LNILQDSNRTTEEITSDSLVAETSI	0.0
6:32164798-32164798 T>G	1.0	4189	MELANOMA	-	-	-	-	NOTCH4	uc003obb.3,p.T1702P|uc011dpt.2,p.T111P|ENST00000443903,p.T111P|NM_004557,p.T1702P|uc003oba.3,p.T362P|uc011dpw.1,p.T111P|ENST00000375023,p.T1702P	retained_intron, protein_coding, processed_transcript	uc011dpw.1	nonsynonymous SNV	exon2	c.A331C	p.T111P	RQTAVDARTEDGTTPLMLAARLAVE	RQTAVDARTEDGPTPLMLAARLAVE	5.0	5.0	-	-	4189_6:32164798-32164798 T>G_RQTAVDARTEDGPTPLMLAARLAVE	0.0
3:125271508-125271508 A>T	1.0	3713	MELANOMA	-	-	-	-	OSBPL11	ENST00000296220,p.F391I|NM_022776,p.F391I|uc003eic.3,p.F391I	protein_coding	uc003eic.3	nonsynonymous SNV	exon9	c.T1171A	p.F391I	LGMDLTRVVLPTFILEKRSLLEMYA	LGMDLTRVVLPTIILEKRSLLEMYA	3.0	7.0	-	-	3713_3:125271508-125271508 A>T_LGMDLTRVVLPTIILEKRSLLEMYA	0.0
8:143694620-143694620 C>T	0.0	4298	COLORECTAL	-	-	-	-	ARC	ENST00000356613,p.R338H|NM_015193,p.R338H|uc003ywn.2,p.R338H|uc022bca.1,p.R338H	protein_coding, processed_transcript	uc022bca.1	nonsynonymous SNV	exon1	c.G1013A	p.R338H	VGTLQPKLKRFLRHPLPKTLEQLIQ	VGTLQPKLKRFLHHPLPKTLEQLIQ	4.0	2.0	-	-	4298_8:143694620-143694620 C>T_VGTLQPKLKRFLHHPLPKTLEQLIQ	0.0
7:149558208-149558208 A>T	1.0	4329	COLORECTAL	-	-	-	-	ZNF862	NM_001099220,p.K653N|ENST00000223210,p.K653N|uc010lpn.3,p.K653N	retained_intron, protein_coding, processed_transcript	uc010lpn.3	nonsynonymous SNV	exon7	c.A1959T	p.K653N	GIYIRYFKQMEVKESYITLAPLYSE	GIYIRYFKQMEVNESYITLAPLYSE	7.0	3.0	-	-	4329_7:149558208-149558208 A>T_GIYIRYFKQMEVNESYITLAPLYSE	0.0
17:61908399-61908399 C>G	1.0	4252	COLORECTAL	-	-	-	-	PSMC5	ENST00000375812,p.A220G|uc002jcd.3,p.A220G|NM_002805,p.A228G|uc002jcb.3,p.A228G|ENST00000582130,p.A209G|ENST00000581882,p.A220G|NM_001199163,p.A220G|uc010ddy.3,p.A205G|ENST00000584320,p.A220G|ENST00000585123,p.A220G|ENST00000310144,p.A228G|ENST00000580864,p.A220G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010ddy.3	nonsynonymous SNV	exon7	c.C614G	p.A205G	GSELVQKFIGEGARMVRELFVMARE	GSELVQKFIGEGGRMVRELFVMARE	10.0	6.0	-	-	4252_17:61908399-61908399 C>G_GSELVQKFIGEGGRMVRELFVMARE	0.0
4:187153295-187153295 C>T	0.0	2359	MELANOMA	-	-	-	-	KLKB1	ENST00000513864,p.L25F|ENST00000264690,p.L25F|uc003iyy.3,p.L25F|NM_000892,p.L25F|ENST00000428196,p.L25F	retained_intron, protein_coding	uc003iyy.3	nonsynonymous SNV	exon3	c.C73T	p.L25F	LFATVSCGCLTQLYENAFFRGGDVA	LFATVSCGCLTQFYENAFFRGGDVA	2.0	2.0	-	-	2359_4:187153295-187153295 C>T_LFATVSCGCLTQFYENAFFRGGDVA	0.0
17:73227673-73227673 G>A	1.0	4252	COLORECTAL	-	-	-	-	NUP85	uc010wrv.1,p.G349D|ENST00000579324,p.G283D|ENST00000579298,p.G350D|NM_024844,p.G395D|ENST00000541827,p.G349D|ENST00000245544,p.G395D|ENST00000447371,p.G227D|uc002jng.1,p.G395D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wrv.1	nonsynonymous SNV	exon12	c.G1046A	p.G349D	HCKLLQSHNLYFGSNMREFLLLEYA	HCKLLQSHNLYFDSNMREFLLLEYA	10.0	10.0	CD8	-	4252_17:73227673-73227673 G>A_HCKLLQSHNLYFDSNMREFLLLEYA	2.0
1:171890926-171890926 G>A	0.0	4155	MELANOMA	-	-	-	-	DNM3	ENST00000358155,p.R67Q|uc001gif.4,p.R67Q|uc001gie.4,p.R67Q|ENST00000520906,p.R67Q|uc001gid.5,p.R67Q|NM_001136127,p.R67Q|uc009wwb.3,p.R67Q|ENST00000367733,p.R67Q|ENST00000367731,p.R67Q|NM_001278252,p.R67Q|NM_015569,p.R67Q|ENST00000355305,p.R67Q	retained_intron, protein_coding	uc009wwb.3	nonsynonymous SNV	exon2	c.G200A	p.R67Q	DFLPRGSGIVTRRPLVLQLVTSKAE	DFLPRGSGIVTRQPLVLQLVTSKAE	3.0	4.0	-	-	4155_1:171890926-171890926 G>A_DFLPRGSGIVTRQPLVLQLVTSKAE	0.0
8:144522463-144522463 C>T	1.0	4136	BREAST	-	-	-	-	ZC3H3	ENST00000262577,p.A855T|uc003yyd.2,p.A855T|NM_015117,p.A855T	protein_coding	uc003yyd.2	nonsynonymous SNV	exon11	c.G2563A	p.A855T	TPSSAALTAAAVAAPPHCPGGSASP	TPSSAALTAAAVTAPPHCPGGSASP	6.0	8.0	-	-	4136_8:144522463-144522463 C>T_TPSSAALTAAAVTAPPHCPGGSASP	0.0
11:27114898-27114898 A>G	0.0	2591	MELANOMA	-	-	-	-	BBOX1	ENST00000525090,p.Y173C|ENST00000528583,p.Y173C|NM_003986,p.Y173C|ENST00000529202,p.Y173C|ENST00000263182,p.Y173C|uc001mre.1,p.Y173C|uc009yih.1,p.Y173C|uc021qfd.1,p.Y173C|uc001mrg.1,p.Y173C	retained_intron, protein_coding, processed_transcript	uc021qfd.1	nonsynonymous SNV	exon3	c.A518G	p.Y173C	EVSKLGKRMGFLYLTFYGHTWQVQD	EVSKLGKRMGFLCLTFYGHTWQVQD	1.0	9.0	-	-	2591_11:27114898-27114898 A>G_EVSKLGKRMGFLCLTFYGHTWQVQD	0.0
13:76378541-76378541 C>T	1.0	3879	MELANOMA	-	-	-	-	LMO7	uc010thw.2,p.R221C|uc001vjt.1,p.R260C|ENST00000357063,p.R312C|uc001vjw.1,p.R27C|ENST00000489941,p.R27C|ENST00000377534,p.R312C|ENST00000341547,p.R312C|uc021rkq.1,p.R260C|ENST00000526371,p.R27C|ENST00000525373,p.R27C|ENST00000377499,p.R260C|ENST00000526202,p.R221C|ENST00000321797,p.R27C|ENST00000526528,p.R27C|ENST00000497947,p.R27C|ENST00000465261,p.R27C|uc001vjv.3,p.R27C|uc010thv.2,p.R312C|NM_015842,p.R27C|NM_005358,p.R312C	retained_intron, protein_coding, processed_transcript	uc021rkq.1	nonsynonymous SNV	exon8	c.C778T	p.R260C	SAVEPKTALPFNRFLPNKSRQPSYV	SAVEPKTALPFNCFLPNKSRQPSYV	6.0	3.0	-	-	3879_13:76378541-76378541 C>T_SAVEPKTALPFNCFLPNKSRQPSYV	0.0
3:138665224-138665224 T>G	0.0	4298	COLORECTAL	-	-	-	1	FOXL2	uc003esw.3,p.K114T|NM_023067,p.K114T|ENST00000330315,p.K114T	protein_coding	uc003esw.3	nonsynonymous SNV	exon1	c.A341C	p.K114T	IRHNLSLNECFIKVPREGGGERKGN	IRHNLSLNECFITVPREGGGERKGN	3.0	9.0	-	-	4298_3:138665224-138665224 T>G_IRHNLSLNECFITVPREGGGERKGN	0.0
2:135180489-135180489 A>C	1.0	4037	NSCLC	-	-	-	-	MGAT5	ENST00000281923,p.K598T|uc002ttw.4,p.K598T|ENST00000409645,p.K598T|NM_002410,p.K598T	protein_coding, processed_transcript	uc002ttw.4	nonsynonymous SNV	exon13	c.A1793C	p.K598T	EVEDAVKAILNQKIEPYMPYEFTCE	EVEDAVKAILNQTIEPYMPYEFTCE	9.0	7.0	-	-	4037_2:135180489-135180489 A>C_EVEDAVKAILNQTIEPYMPYEFTCE	0.0
7:87006675-87006675 C>T	0.0	4258	ENDOMETRIAL	-	-	-	-	CROT	NM_001143935,p.A324V|ENST00000331536,p.A296V|NM_021151,p.A296V|ENST00000442291,p.A296V|uc003uiu.3,p.A324V|uc003uit.3,p.A296V|ENST00000419147,p.A324V	retained_intron, protein_coding	uc003uiu.3	nonsynonymous SNV	exon11	c.C971T	p.A324V	HVTPEDYSEIIAAILIGDPTVRWGD	HVTPEDYSEIIAVILIGDPTVRWGD	4.0	6.0	-	-	4258_7:87006675-87006675 C>T_HVTPEDYSEIIAVILIGDPTVRWGD	0.0
1:202092540-202092540 C>T	1.0	4284	COLORECTAL	-	-	ID=COSM3803468;OCCURENCE=1(breast)	-	GPR37L1	uc001gxj.3,p.S150L|ENST00000367282,p.S150L|NM_004767,p.S150L	protein_coding	uc001gxj.3	nonsynonymous SNV	exon1	c.C449T	p.S150L	LVVFAVGIVGNLSVMCIVWHSYYLK	LVVFAVGIVGNLLVMCIVWHSYYLK	3.0	10.0	-	-	4284_1:202092540-202092540 C>T_LVVFAVGIVGNLLVMCIVWHSYYLK	0.0
11:6422860-6422860 G>A	1.0	3713	MELANOMA	0.0005	-	ID=COSM1580511;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),2(large_intestine)	-	APBB1	uc010rad.2,p.R200C|NM_001164,p.R483C|ENST00000299402,p.R481C|NM_145689,p.R481C|NM_001257321,p.R224C|ENST00000530885,p.R261C|uc001mdd.4,p.R261C|NM_001257319,p.R263C|ENST00000533407,p.R222C|NM_001257325,p.R248C|uc031pyu.1,p.R481C|NM_001257323,p.R261C|ENST00000311051,p.R481C|NM_001257326,p.R224C|uc001mdc.1,p.R481C|NM_001257320,p.R224C|ENST00000389906,p.R483C	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031pyu.1	nonsynonymous SNV	exon9	c.C1441T	p.R481C	DKLTQMLKCHVFRCEAPAKNIATSL	DKLTQMLKCHVFCCEAPAKNIATSL	4.0	3.0	-	-	3713_11:6422860-6422860 G>A_DKLTQMLKCHVFCCEAPAKNIATSL	0.0
9:140057067-140057067 G>A	1.0	4281	COLORECTAL	-	-	-	-	GRIN1	ENST00000371555,p.R651H|ENST00000315048,p.R630H|uc004clj.1,p.R627H|ENST00000350902,p.R630H|uc004cli.1,p.R305H|ENST00000371546,p.R651H|NM_021569,p.R630H|ENST00000371561,p.R630H|uc004clm.3,p.R630H|ENST00000371553,p.R651H|uc004cll.3,p.R630H|ENST00000371559,p.R630H|NM_001185091,p.R651H|NM_007327,p.R630H|uc004clk.3,p.R630H|NM_001185090,p.R651H|uc004cln.3,p.R651H|ENST00000371550,p.R630H|ENST00000371560,p.R651H|NM_000832,p.R630H|uc004clo.3,p.R651H	protein_coding, processed_transcript	uc004clo.3	nonsynonymous SNV	exon15	c.G1952A	p.R651H	GIGEGAPRSFSARILGMVWAGFAMI	GIGEGAPRSFSAHILGMVWAGFAMI	3.0	8.0	-	-	4281_9:140057067-140057067 G>A_GIGEGAPRSFSAHILGMVWAGFAMI	0.0
1:152189004-152189004 C>T	1.0	3879	MELANOMA	-	-	-	-	HRNR	NM_001009931,p.G1701S|ENST00000368801,p.G1701S|uc001ezt.2,p.G1701S	protein_coding	uc001ezt.2	nonsynonymous SNV	exon3	c.G5101A	p.G1701S	YGQHGSGSRQSSGHGRQGSGSGQSP	YGQHGSGSRQSSSHGRQGSGSGQSP	1.0	1.0	-	-	3879_1:152189004-152189004 C>T_YGQHGSGSRQSSSHGRQGSGSGQSP	0.0
21:35206692-35206692 C>T	1.0	3713	MELANOMA	-	-	-	-	ITSN1	NM_001001132,p.P1145S|uc002ysz.3,p.P1069S|uc010gmj.3,p.P1024S|ENST00000399349,p.P1069S|uc002yta.1,p.P1145S|ENST00000381291,p.P1145S|uc010gmg.3,p.P1032S|ENST00000381285,p.P1145S|ENST00000381318,p.P1145S|NM_003024,p.P1145S|uc002ytj.2,p.P1140S|uc002ysx.3,p.P1103S|ENST00000399353,p.P1103S|uc002ysw.3,p.P1145S|uc002ytb.1,p.P1140S|ENST00000437442,p.P1140S|uc021wip.1,p.P963S|uc002yte.3,p.P1008S|ENST00000399352,p.P1140S|uc010gmk.3,p.P1037S|ENST00000399355,p.P1074S|uc002ysy.3,p.P1140S|uc010gmi.3,p.P1108S|ENST00000399367,p.P1140S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021wip.1	nonsynonymous SNV	exon20	c.C2887T	p.P963S	VKLLSPGTSKITPTEPPKSTALAAV	VKLLSPGTSKITSTEPPKSTALAAV	4.0	8.0	-	-	3713_21:35206692-35206692 C>T_VKLLSPGTSKITSTEPPKSTALAAV	0.0
19:52249734-52249734 C>T	0.0	3903	MELANOMA	-	-	-	-	FPR1	NM_001193306,p.G172R|NM_002029,p.G172R|ENST00000600815,p.G172R|uc021uyo.1,p.G172R|uc002pxq.3,p.G172R|ENST00000595042,p.G172R|ENST00000304748,p.G172R|uc021uyn.1,p.G172R	protein_coding	uc021uyo.1	nonsynonymous SNV	exon1	c.G514A	p.G172R	VIIRVTTVPGKTGTVACTFNFSPWT	VIIRVTTVPGKTRTVACTFNFSPWT	8.0	8.0	-	-	3903_19:52249734-52249734 C>T_VIIRVTTVPGKTRTVACTFNFSPWT	0.0
1:237774245-237774245 G>T	0.0	4158	COLORECTAL	-	-	-	-	RYR2	NM_001035,p.D1623Y|ENST00000360064,p.D1621Y|ENST00000542537,p.D1607Y|ENST00000366574,p.D1623Y|uc001hyl.1,p.D1623Y	protein_coding, processed_transcript	uc001hyl.1	nonsynonymous SNV	exon36	c.G4867T	p.D1623Y	ISERQGWLVQCLDPLQFMSLHIPEE	ISERQGWLVQCLYPLQFMSLHIPEE	4.0	8.0	-	-	4158_1:237774245-237774245 G>T_ISERQGWLVQCLYPLQFMSLHIPEE	0.0
5:127668648-127668648 C>A	0.0	4329	COLORECTAL	-	-	-	-	FBN2	ENST00000507835,p.C243F|uc003kuv.2,p.C1360F|ENST00000262464,p.C1393F|ENST00000508053,p.C1393F|NM_001999,p.C1393F|uc003kuu.3,p.C1393F|ENST00000508989,p.C1360F	retained_intron, protein_coding, processed_transcript	uc003kuv.2	nonsynonymous SNV	exon31	c.G4079T	p.C1360F	HASCLNIPGSFKCSCREGWIGNGIK	HASCLNIPGSFKFSCREGWIGNGIK	3.0	3.0	-	-	4329_5:127668648-127668648 C>A_HASCLNIPGSFKFSCREGWIGNGIK	0.0
12:98941500-98941500 C>T	1.0	2556	MELANOMA	-	-	-	-	TMPO	uc001tfk.3,p.S301F|NM_001032283,p.S410F|uc001tfj.3,p.S410F|ENST00000393053,p.S301F|NM_001032284,p.S301F|ENST00000343315,p.S370F|ENST00000556029,p.S410F	retained_intron, protein_coding, processed_transcript	uc001tfk.3	nonsynonymous SNV	exon6	c.C902T	p.S301F	ADVKSEKTKKGRSIPVWIKILLFVV	ADVKSEKTKKGRFIPVWIKILLFVV	10.0	9.0	-	-	2556_12:98941500-98941500 C>T_ADVKSEKTKKGRFIPVWIKILLFVV	0.0
17:79094576-79094576 C>T	1.0	4000	MELANOMA	-	-	-	-	AATK	ENST00000417379,p.E951K|uc010dia.3,p.E1054K|uc021ueu.1,p.E951K|NM_001080395,p.E1054K|ENST00000326724,p.E1054K|NM_004920,p.E951K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ueu.1	nonsynonymous SNV	exon10	c.G2851A	p.E951K	GVSGEAQGSGPGEVLPPLLQLEGSS	GVSGEAQGSGPGKVLPPLLQLEGSS	5.0	10.0	-	-	4000_17:79094576-79094576 C>T_GVSGEAQGSGPGKVLPPLLQLEGSS	0.0
2:148653983-148653983 C>T	0.0	4235	COLORECTAL	-	-	ID=COSM1399821;OCCURENCE=1(large_intestine)	1	ACVR2A	NM_001278579,p.R57W|ENST00000241416,p.R57W|NM_001616,p.R57W|ENST00000404590,p.R57W|uc002twh.3,p.R57W|uc002twg.3,p.R57W	retained_intron, protein_coding, processed_transcript	uc002twh.3	nonsynonymous SNV	exon2	c.C169T	p.R57W	TGVEPCYGDKDKRRHCFATWKNISG	TGVEPCYGDKDKWRHCFATWKNISG	7.0	5.0	-	-	4235_2:148653983-148653983 C>T_TGVEPCYGDKDKWRHCFATWKNISG	0.0
4:89338673-89338673 C>T	1.0	3466	MELANOMA	-	-	-	-	HERC6	NM_001165136,p.T552I|ENST00000380265,p.T552I|uc011cdj.2,p.T552I|ENST00000264346,p.T552I|NM_017912,p.T552I|uc011cdi.2,p.T552I	retained_intron, protein_coding, nonsense_mediated_decay	uc011cdj.2	nonsynonymous SNV	exon13	c.C1655T	p.T552I	AAIISQLLHQTKTEQDHCNVKALLG	AAIISQLLHQTKIEQDHCNVKALLG	6.0	2.0	-	-	3466_4:89338673-89338673 C>T_AAIISQLLHQTKIEQDHCNVKALLG	0.0
5:40843312-40843314 AGA>-	0.0	4238	COLORECTAL	-	-	-	-	CARD6	NM_032587,p.114_115del|uc003jmg.3,p.114_115del|ENST00000254691,p.114_115del|ENST00000381677,p.114_115del	protein_coding	uc003jmg.3	nonframeshift deletion	exon2	c.342_344del	p.114_115del	TVPPQSMGASSNSEDAFSPGIKQPE	TVPPQSMGASSNSDAFSPGIKQPEA	3.0	4.0	-	-	4238_5:40843312-40843314 AGA>-_TVPPQSMGASSNSDAFSPGIKQPEA	0.0
3:48698992-48698992 C>T	1.0	4266	COLORECTAL	-	-	-	-	CELSR3	NM_001407,p.R359H|ENST00000164024,p.R359H|uc003cuf.1,p.R429H|ENST00000544264,p.R359H|uc003cul.3,p.R359H	retained_intron, protein_coding	uc003cul.3	nonsynonymous SNV	exon1	c.G1076A	p.R359H	VVAQDPDAGEAGRLVYSLAALMNSR	VVAQDPDAGEAGHLVYSLAALMNSR	5.0	7.0	-	-	4266_3:48698992-48698992 C>T_VVAQDPDAGEAGHLVYSLAALMNSR	0.0
3:151056195-151056195 C>T	0.0	4245	COLORECTAL	-	-	-	-	P2RY12	uc003eyw.1,p.V147I|uc003eyx.1,p.V147I|NM_176876,p.V147I|uc021xga.1,p.V147I|ENST00000302632,p.V147I|NM_022788,p.V147I	retained_intron, protein_coding	uc021xga.1	nonsynonymous SNV	exon1	c.G439A	p.V147I	PKNLLGAKILSVVIWAFMFLLSLPN	PKNLLGAKILSVIIWAFMFLLSLPN	4.0	9.0	-	-	4245_3:151056195-151056195 C>T_PKNLLGAKILSVIIWAFMFLLSLPN	0.0
6:128388773-128388773 G>A	1.0	4000	MELANOMA	-	-	ID=COSM236211;OCCURENCE=1(autonomic_ganglia)	1	PTPRK	ENST00000368226,p.A683V|ENST00000532331,p.A683V|NM_002844,p.A683V|ENST00000368227,p.A683V|ENST00000368210,p.A683V|uc003qbl.1,p.A553V|ENST00000368215,p.A683V|NM_001291982,p.A683V|ENST00000368207,p.A683V|ENST00000368213,p.A683V|NM_001291983,p.A554V|uc003qbj.3,p.A683V|uc011ebu.2,p.A683V|NM_001135648,p.A683V|uc010kfc.3,p.A683V|uc011ebv.1,p.A683V|NM_001291981,p.A683V|NM_001291984,p.A683V|uc003qbk.3,p.A683V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011ebv.1	nonsynonymous SNV	exon12	c.C2048T	p.A683V	AAELPPGNLPEPAPFTVGDNRTYQG	AAELPPGNLPEPVPFTVGDNRTYQG	1.0	5.0	-	-	4000_6:128388773-128388773 G>A_AAELPPGNLPEPVPFTVGDNRTYQG	0.0
7:148768242-148768242 T>G	1.0	4329	COLORECTAL	-	-	-	-	ZNF786	ENST00000451334,p.K504T|ENST00000316286,p.K455T|ENST00000491431,p.K541T|uc003wfh.2,p.K541T|uc011kuk.1,p.K504T|NM_152411,p.K541T|uc003wfi.2,p.K455T	protein_coding	uc011kuk.1	nonsynonymous SNV	exon5	c.A1511C	p.K504T	RVHSGERPFQCLKCDKRFRLKGILK	RVHSGERPFQCLTCDKRFRLKGILK	5.0	3.0	-	-	4329_7:148768242-148768242 T>G_RVHSGERPFQCLTCDKRFRLKGILK	0.0
X:119389123-119389123 A>C	0.0	4335	COLORECTAL	-	-	-	-	ZBTB33	uc010nqm.1,p.K618T|NM_006777,p.K618T|uc022cdm.1,p.K618T|NM_001184742,p.K618T|ENST00000326624,p.K618T|uc004esn.1,p.K618T|ENST00000557385,p.K618T	protein_coding	uc022cdm.1	nonsynonymous SNV	exon1	c.A1853C	p.K618T	TIPAMKDDGIGYKVDTGKEPPVGTT	TIPAMKDDGIGYTVDTGKEPPVGTT	6.0	4.0	-	-	4335_X:119389123-119389123 A>C_TIPAMKDDGIGYTVDTGKEPPVGTT	0.0
9:43626759-43626759 G>A	0.0	4177	PANCREATIC	-	rs2491539	-	-	SPATA31A6	ENST00000332857,p.T643M|uc011lrb.2,p.T643M|NM_001145196,p.T643M	protein_coding, processed_transcript	uc011lrb.2	nonsynonymous SNV	exon4	c.C1928T	p.T643M	QAKGKPSPWQSSTSTGESSKEAQKV	QAKGKPSPWQSSMSTGESSKEAQKV	1.0	9.0	-	-	4177_9:43626759-43626759 G>A_QAKGKPSPWQSSMSTGESSKEAQKV	0.0
7:149171717-149171717 G>T	1.0	4240	BREAST	-	-	-	-	ZNF746	uc010lpi.2,p.P566T|ENST00000340622,p.P565T|uc003wfw.2,p.P565T|ENST00000458143,p.P566T|NM_001163474,p.P566T|NM_152557,p.P565T	retained_intron, protein_coding	uc010lpi.2	nonsynonymous SNV	exon7	c.C1696A	p.P566T	LIDHYRTHTGVRPFTCTVCGKSFIR	LIDHYRTHTGVRTFTCTVCGKSFIR	7.0	9.0	-	-	4240_7:149171717-149171717 G>T_LIDHYRTHTGVRTFTCTVCGKSFIR	0.0
8:11188884-11188884 G>A	0.0	4346	COLORECTAL	0.0009	-	-	-	SLC35G5	uc003wtp.1,p.R90H|NM_054028,p.R90H|ENST00000382435,p.R90H	protein_coding	uc003wtp.1	nonsynonymous SNV	exon1	c.G269A	p.R90H	LFHLPIALLLKLRGDPLLGPPDIRG	LFHLPIALLLKLHGDPLLGPPDIRG	3.0	2.0	-	-	4346_8:11188884-11188884 G>A_LFHLPIALLLKLHGDPLLGPPDIRG	0.0
4:145628255-145628255 G>A	1.0	4069	PANCREATIC	-	-	-	-	HHIP	uc003ijs.2,p.V334I|NM_022475,p.V334I|ENST00000296575,p.V334I	retained_intron, protein_coding, processed_transcript	uc003ijs.2	nonsynonymous SNV	exon6	c.G1000A	p.V334I	VEYTVSRKNPHQVDLRTARVFLEVA	VEYTVSRKNPHQIDLRTARVFLEVA	4.0	10.0	-	-	4069_4:145628255-145628255 G>A_VEYTVSRKNPHQIDLRTARVFLEVA	0.0
1:182554693-182554693 A>C	1.0	4329	COLORECTAL	-	-	-	-	RNASEL	uc009wxz.2,p.L417V|ENST00000367559,p.L417V|uc009wya.1,p.L417V|NM_021133,p.L417V|ENST00000444138,p.L417V|ENST00000539397,p.L417V|uc001gpk.3,p.L417V	protein_coding	uc009wya.1	nonsynonymous SNV	exon1	c.T1249G	p.L417V	VSCLQSSRENSHLVTFYGSESHRGH	VSCLQSSRENSHVVTFYGSESHRGH	5.0	3.0	-	-	4329_1:182554693-182554693 A>C_VSCLQSSRENSHVVTFYGSESHRGH	0.0
16:3350226-3350226 C>T	1.0	3998	MELANOMA	-	-	ID=COSM3377889;OCCURENCE=1(pancreas)	-	TIGD7	ENST00000268674,p.R130Q|ENST00000396862,p.R130Q|NM_033208,p.R130Q|uc021tcc.1,p.R130Q|uc002cus.3,p.R130Q	protein_coding, processed_transcript	uc021tcc.1	nonsynonymous SNV	exon1	c.G389A	p.R130Q	DFKASTGWLFRFRNRHAIGNRKGCG	DFKASTGWLFRFQNRHAIGNRKGCG	5.0	7.0	-	-	3998_16:3350226-3350226 C>T_DFKASTGWLFRFQNRHAIGNRKGCG	0.0
11:34378964-34378964 C>A	0.0	4149	OVARIAN	-	-	-	-	ABTB2	uc001mvl.2,p.C56F|NM_145804,p.C56F|ENST00000435224,p.C56F	protein_coding, processed_transcript	uc001mvl.2	nonsynonymous SNV	exon1	c.G167T	p.C56F	SSAQQHRGAAWWCYSGSMNSRHNSW	SSAQQHRGAAWWFYSGSMNSRHNSW	1.0	4.0	-	-	4149_11:34378964-34378964 C>A_SSAQQHRGAAWWFYSGSMNSRHNSW	0.0
16:2747924-2747924 G>A	1.0	4240	BREAST	-	-	-	-	KCTD5	ENST00000301738,p.E127K|NM_018992,p.E127K|uc002crd.3,p.E127K	protein_coding, processed_transcript	uc002crd.3	nonsynonymous SNV	exon3	c.G379A	p.E127K	KDLAEEGVLEEAEFYNITSLIKLVK	KDLAEEGVLEEAKFYNITSLIKLVK	8.0	10.0	-	-	4240_16:2747924-2747924 G>A_KDLAEEGVLEEAKFYNITSLIKLVK	0.0
7:103275990-103275990 T>C	0.0	3795	MELANOMA	-	-	-	-	RELN	uc010liz.3,p.S783G|ENST00000428762,p.S783G|NM_005045,p.S783G|ENST00000424685,p.S783G|uc022ajq.1,p.S783G|ENST00000343529,p.S783G|uc022ajr.1,p.S783G|NM_173054,p.S783G	retained_intron, protein_coding, processed_transcript	uc022ajr.1	nonsynonymous SNV	exon19	c.A2347G	p.S783G	QFTLRLGSKSVLSTCRAPDQPGEGV	QFTLRLGSKSVLGTCRAPDQPGEGV	2.0	2.0	-	-	3795_7:103275990-103275990 T>C_QFTLRLGSKSVLGTCRAPDQPGEGV	0.0
2:219513378-219513378 C>A	1.0	4129	NSCLC	-	-	-	-	ZNF142	uc002vil.3,p.R379L|NM_001105537,p.R418L|uc002vim.4,p.R255L|ENST00000449707,p.R418L|uc002vin.4,p.R418L|ENST00000411696,p.R418L|uc010fvt.4,p.R255L	protein_coding, nonsense_mediated_decay	uc010fvt.4	nonsynonymous SNV	exon7	c.G764T	p.R255L	CNFATAHKRVLIRHMLLHTGEKPHK	CNFATAHKRVLILHMLLHTGEKPHK	6.0	6.0	-	-	4129_2:219513378-219513378 C>A_CNFATAHKRVLILHMLLHTGEKPHK	0.0
3:186505004-186505004 A>G	1.0	4180	BREAST	-	-	-	1	EIF4A2	uc003fqv.3,p.D192G|ENST00000425053,p.D287G|uc011bsb.2,p.D160G|ENST00000356531,p.D192G|ENST00000440191,p.D288G|ENST00000323963,p.D287G|uc003fqs.3,p.D287G|uc003fqw.3,p.D192G|uc003fqu.3,p.D288G|NM_001967,p.D287G	retained_intron, protein_coding, nonsense_mediated_decay	uc011bsb.2	nonsynonymous SNV	exon4	c.A479G	p.D160G	QAVIFLNTRRKVDWLTEKMHARDFT	QAVIFLNTRRKVGWLTEKMHARDFT	10.0	5.0	-	-	4180_3:186505004-186505004 A>G_QAVIFLNTRRKVGWLTEKMHARDFT	0.0
3:52428517-52428517 T>C	0.0	4335	COLORECTAL	-	-	-	-	DNAH1	ENST00000420323,p.S3555P|uc003ddv.3,p.S413P|NM_015512,p.S3555P|uc011bef.2,p.S3555P|ENST00000490713,p.S455P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bef.2	nonsynonymous SNV	exon67	c.T10663C	p.S3555P	SEWRYLLSGGSISIMTENPAPDWLS	SEWRYLLSGGSIPIMTENPAPDWLS	9.0	6.0	-	-	4335_3:52428517-52428517 T>C_SEWRYLLSGGSIPIMTENPAPDWLS	0.0
4:16165022-16165022 G>A	1.0	4037	NSCLC	-	-	-	-	TAPT1	uc010ied.1,p.T538M|NM_153365,p.T538M|uc011bxe.1,p.T427M|ENST00000399920,p.T427M|ENST00000405303,p.T538M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bxe.1	nonsynonymous SNV	exon13	c.C1280T	p.T427M	FLTTPDGDEKDITQDNSELKHRSSK	FLTTPDGDEKDIMQDNSELKHRSSK	7.0	10.0	-	-	4037_4:16165022-16165022 G>A_FLTTPDGDEKDIMQDNSELKHRSSK	0.0
6:70608903-70608903 T>A	0.0	4258	ENDOMETRIAL	-	-	-	-	COL19A1	NM_001858,p.L52H|uc003pfc.1,p.L52H|ENST00000322773,p.L52H	protein_coding, processed_transcript	uc003pfc.1	nonsynonymous SNV	exon3	c.T155A	p.L52H	EGHQLTYDNINKLEVSGFDLGDSFS	EGHQLTYDNINKHEVSGFDLGDSFS	4.0	8.0	-	-	4258_6:70608903-70608903 T>A_EGHQLTYDNINKHEVSGFDLGDSFS	0.0
12:100452524-100452524 T>A	0.0	4158	COLORECTAL	-	-	-	-	UHRF1BP1L	uc001tgq.3,p.D844V|uc001tgp.3,p.D494V|ENST00000279907,p.D844V|ENST00000545232,p.D494V|NM_015054,p.D844V	retained_intron, protein_coding, nonsense_mediated_decay	uc001tgq.3	nonsynonymous SNV	exon14	c.A2531T	p.D844V	ESLILLSENLRKDVEAVTGSPASQT	ESLILLSENLRKVVEAVTGSPASQT	5.0	4.0	-	-	4158_12:100452524-100452524 T>A_ESLILLSENLRKVVEAVTGSPASQT	0.0
10:31138595-31138595 T>G	1.0	4287	COLORECTAL	-	-	-	-	ZNF438	NM_182755,p.T247P|ENST00000413025,p.T247P|NM_001143770,p.T237P|uc001ivp.4,p.T237P|uc001ivn.3,p.T198P|ENST00000452305,p.T237P|uc010qeb.2,p.T247P|ENST00000444692,p.T237P|uc010qea.2,p.T247P|ENST00000442986,p.T247P|NM_001143768,p.T247P|ENST00000436087,p.T247P|uc009xlg.3,p.T247P|ENST00000538351,p.T198P|uc010qdy.2,p.T237P|ENST00000331737,p.T237P|ENST00000361310,p.T247P|NM_001143771,p.T237P|uc010qdz.2,p.T247P|NM_001143769,p.T198P|NM_001143767,p.T247P|NM_001143766,p.T247P	protein_coding	uc010qeb.2	nonsynonymous SNV	exon5	c.A739C	p.T247P	ALSGKAHFVSKITSSKPSAVASEKF	ALSGKAHFVSKIPSSKPSAVASEKF	5.0	10.0	-	-	4287_10:31138595-31138595 T>G_ALSGKAHFVSKIPSSKPSAVASEKF	0.0
19:17115116-17115116 C>A	1.0	4129	NSCLC	-	-	-	-	CPAMD8	ENST00000291440,p.A261S|ENST00000443236,p.A261S|ENST00000388925,p.A214S|uc002nfb.3,p.A261S|NM_015692,p.A261S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002nfb.3	nonsynonymous SNV	exon8	c.G781T	p.A261S	GEWFIFVEMQGHAYNKSFEVQKYVL	GEWFIFVEMQGHSYNKSFEVQKYVL	4.0	9.0	-	-	4129_19:17115116-17115116 C>A_GEWFIFVEMQGHSYNKSFEVQKYVL	0.0
1:113235481-113235481 A>G	1.0	4126	NSCLC	-	-	-	-	MOV10	NM_001286072,p.H301R|uc001ecm.3,p.H297R|uc001ecn.3,p.H357R|NM_001130079,p.H357R|ENST00000357443,p.H357R|uc009wgj.1,p.H297R|NM_020963,p.H357R|ENST00000369644,p.H301R|uc001ecl.2,p.H357R|uc001eck.3,p.H357R|ENST00000369645,p.H357R|ENST00000413052,p.H357R	protein_coding, processed_transcript	uc009wgj.1	nonsynonymous SNV	exon7	c.A890G	p.H297R	HLEELQMEHDIRHYDLESVPMTWDP	HLEELQMEHDIRRYDLESVPMTWDP	9.0	8.0	-	-	4126_1:113235481-113235481 A>G_HLEELQMEHDIRRYDLESVPMTWDP	0.0
X:8565143-8565143 G>C	0.0	4238	COLORECTAL	-	-	-	-	KAL1	NM_000216,p.S158C|uc004csf.3,p.S158C|ENST00000262648,p.S158C	protein_coding, processed_transcript	uc004csf.3	nonsynonymous SNV	exon4	c.C473G	p.S158C	ACVESCEVDNECSGVKKCCSNGCGH	ACVESCEVDNECCGVKKCCSNGCGH	2.0	7.0	-	-	4238_X:8565143-8565143 G>C_ACVESCEVDNECCGVKKCCSNGCGH	0.0
12:4747350-4747350 C>T	0.0	4237	NSCLC	-	-	-	-	AKAP3	ENST00000540967,p.V5I|uc031qfv.1,p.V5I|ENST00000545990,p.V5I|ENST00000228850,p.V5I|NM_006422,p.V5I|ENST00000536414,p.V5I|NM_001278309,p.V5I|uc001qnb.4,p.V5I	protein_coding, processed_transcript	uc031qfv.1	nonsynonymous SNV	exon4	c.G13A	p.V5I	MSEKVDWLQSQNGVCKV	MSEKIDWLQSQNGVCKV	4.0	9.0	-	-	4237_12:4747350-4747350 C>T_MSEKIDWLQSQNGVCKV	0.0
17:56440739-56440739 G>A	1.0	4160	COLORECTAL	-	-	-	1	RNF43	uc002iwf.3,p.P160L|uc002iwh.4,p.P160L|uc002iwg.4,p.P160L|uc010dcw.3,p.P33L|ENST00000407977,p.P160L|ENST00000581868,p.P33L|ENST00000583753,p.P119L|NM_017763,p.P160L|ENST00000500597,p.P119L|uc010wnv.2,p.P119L|ENST00000577625,p.P33L|ENST00000584437,p.P160L|ENST00000577716,p.P160L	retained_intron, protein_coding, processed_transcript	uc010wnv.2	nonsynonymous SNV	exon3	c.C356T	p.P119L	AEQLQQPLGLTWPVVLIWGNDAEKL	AEQLQQPLGLTWLVVLIWGNDAEKL	10.0	10.0	-	-	4160_17:56440739-56440739 G>A_AEQLQQPLGLTWLVVLIWGNDAEKL	0.0
5:50679518-50679518 G>A	0.0	3903	MELANOMA	-	-	ID=COSM1620356;OCCURENCE=2(liver)	-	ISL1	NM_002202,p.G5R|ENST00000230658,p.G5R|ENST00000511384,p.G5R|uc003jor.3,p.G5R	protein_coding	uc003jor.3	nonsynonymous SNV	exon1	c.G13A	p.G5R	MGDMGDPPKKKRLISLC	MGDMRDPPKKKRLISLC	2.0	6.0	-	-	3903_5:50679518-50679518 G>A_MGDMRDPPKKKRLISLC	0.0
7:100350487-100350487 C>A	0.0	4110	BILE DUCT	-	-	-	-	ZAN	ENST00000546292,p.P920H|uc003uwk.3,p.P920H|uc003uwj.3,p.P920H|ENST00000538115,p.P920H|ENST00000542585,p.P920H	protein_coding, polymorphic_pseudogene	uc003uwk.3	nonsynonymous SNV	exon14	c.C2759A	p.P920H	ISPEKPTISTEKPTIPTEKPTIPTE	ISPEKPTISTEKHTIPTEKPTIPTE	1.0	7.0	-	-	4110_7:100350487-100350487 C>A_ISPEKPTISTEKHTIPTEKPTIPTE	0.0
3:27763340-27763340 G>A	0.0	4258	ENDOMETRIAL	-	-	-	-	EOMES	ENST00000449599,p.P149L|NM_001278182,p.P149L|uc003cdy.4,p.P149L|uc003cdx.4,p.P149L|ENST00000295743,p.P149L|uc010hfn.3,p.P149L|NM_005442,p.P149L	protein_coding, processed_transcript	uc010hfn.3	nonsynonymous SNV	exon1	c.C446T	p.P149L	DSLSSERYYLQSPGPQGSELAAPCS	DSLSSERYYLQSLGPQGSELAAPCS	5.0	4.0	-	-	4258_3:27763340-27763340 G>A_DSLSSERYYLQSLGPQGSELAAPCS	0.0
19:54756803-54756803 C>T	0.0	4326	BREAST	-	-	-	-	LILRB5	uc002qez.3,p.V369I|uc002qey.3,p.V469I|NM_006840,p.V468I|NM_001081443,p.V369I|uc002qex.3,p.V468I|NM_001081442,p.V469I|ENST00000345866,p.V369I|ENST00000450632,p.V460I|ENST00000316219,p.V468I|uc010yer.1,p.V460I|ENST00000449561,p.V469I	retained_intron, protein_coding	uc010yer.1	nonsynonymous SNV	exon9	c.G1378A	p.V460I	HLGVVTGVSVAFVLLLFLLLFLLLR	HLGVVTGVSVAFILLLFLLLFLLLR	5.0	9.0	-	-	4326_19:54756803-54756803 C>T_HLGVVTGVSVAFILLLFLLLFLLLR	0.0
1:32714117-32714117 G>A	1.0	4258	ENDOMETRIAL	-	-	-	-	FAM167B	uc001buw.3,p.G136E|NM_032648,p.G136E|ENST00000373582,p.G136E	protein_coding	uc001buw.3	nonsynonymous SNV	exon2	c.G407A	p.G136E	LDEAELELELEPGAGLALAPLLRHL	LDEAELELELEPEAGLALAPLLRHL	6.0	3.0	-	-	4258_1:32714117-32714117 G>A_LDEAELELELEPEAGLALAPLLRHL	0.0
1:209799350-209799350 C>T	1.0	3713	MELANOMA	-	-	-	-	LAMB3	uc001hhh.3,p.G540E|ENST00000367030,p.G540E|NM_001017402,p.G540E|ENST00000391911,p.G540E|NM_000228,p.G540E|NM_001127641,p.G540E|ENST00000356082,p.G540E|uc009xco.3,p.G540E|uc001hhg.3,p.G540E	protein_coding	uc009xco.3	nonsynonymous SNV	exon14	c.G1619A	p.G540E	ATGCRACDCDFRGTEGPGCDKASGR	ATGCRACDCDFRETEGPGCDKASGR	1.0	4.0	-	-	3713_1:209799350-209799350 C>T_ATGCRACDCDFRETEGPGCDKASGR	0.0
20:61574937-61574937 A>T	1.0	4037	NSCLC	-	-	-	-	GID8	ENST00000266069,p.S136C|uc002ydy.3,p.S136C|NM_017896,p.S136C	protein_coding, processed_transcript	uc002ydy.3	nonsynonymous SNV	exon4	c.A406T	p.S136C	FAQTQLAEQGEESRECLTEMERTLA	FAQTQLAEQGEECRECLTEMERTLA	10.0	6.0	-	-	4037_20:61574937-61574937 A>T_FAQTQLAEQGEECRECLTEMERTLA	0.0
12:113545997-113545997 G>C	1.0	3775	CERVICAL	-	-	-	-	RASAL1	ENST00000546530,p.L470V|NM_001193520,p.L470V|uc001tun.2,p.L470V	retained_intron, protein_coding, processed_transcript	uc001tun.2	nonsynonymous SNV	exon15	c.C1408G	p.L470V	QQDVKYLAISGFLFLRFFAPAILTP	QQDVKYLAISGFVFLRFFAPAILTP	5.0	10.0	-	-	3775_12:113545997-113545997 G>C_QQDVKYLAISGFVFLRFFAPAILTP	0.0
1:34164382-34164382 G>T	0.0	4110	BILE DUCT	-	-	-	-	CSMD2	uc001bxm.1,p.T1299N|NM_001281956,p.T1299N|ENST00000241312,p.T1259N|uc001bxo.1,p.T172N|ENST00000373381,p.T1299N|ENST00000373380,p.T172N|uc001bxn.1,p.T1259N|NM_052896,p.T1259N	protein_coding, processed_transcript, nonsense_mediated_decay	uc001bxo.1	nonsynonymous SNV	exon3	c.C515A	p.T172N	SEELLCLSGERRTWDRPLPTCVAEC	SEELLCLSGERRNWDRPLPTCVAEC	2.0	5.0	-	-	4110_1:34164382-34164382 G>T_SEELLCLSGERRNWDRPLPTCVAEC	0.0
4:3216908-3216908 G>A	1.0	2556	MELANOMA	-	-	-	-	HTT	ENST00000355072,p.E2342K	retained_intron, protein_coding, processed_transcript	ENST00000355072	nonsynonymous SNV	exon51	c.G7024A	p.E2342K	ERRTNTPKAISEEEEEVDPNTQNPK	ERRTNTPKAISEKEEEVDPNTQNPK	9.0	8.0	-	-	2556_4:3216908-3216908 G>A_ERRTNTPKAISEKEEEVDPNTQNPK	0.0
20:17474766-17474766 C>T	1.0	4189	MELANOMA	-	-	-	-	BFSP1	NM_001278606,p.G512R|ENST00000536626,p.G512R|uc002wpo.3,p.G651R|uc010zrn.2,p.G512R|ENST00000544874,p.G512R|uc010zro.2,p.G512R|uc002wpp.3,p.G526R|NM_001195,p.G651R|ENST00000377868,p.G526R|ENST00000377873,p.G651R|NM_001161705,p.G526R|NM_001278608,p.G512R|NM_001278607,p.G540R	protein_coding, processed_transcript	uc010zro.2	nonsynonymous SNV	exon10	c.G1534A	p.G512R	YEETAVIVETMIGKTKSDKKKSGEK	YEETAVIVETMIRKTKSDKKKSGEK	3.0	6.0	-	-	4189_20:17474766-17474766 C>T_YEETAVIVETMIRKTKSDKKKSGEK	0.0
12:77417923-77417923 G>A	1.0	3466	MELANOMA	-	-	-	-	E2F7	uc001sym.4,p.R870C|ENST00000322886,p.R870C|NM_203394,p.R870C	retained_intron, protein_coding, nonsense_mediated_decay	uc001sym.4	nonsynonymous SNV	exon13	c.C2608T	p.R870C	VPVTPKSIQRTHRETFFKTPGSLGD	VPVTPKSIQRTHCETFFKTPGSLGD	6.0	9.0	-	-	3466_12:77417923-77417923 G>A_VPVTPKSIQRTHCETFFKTPGSLGD	0.0
2:163374650-163374650 T>G	0.0	4196	COLORECTAL	-	-	-	-	KCNH7	NM_173162,p.K161T|uc002uch.2,p.K161T|uc002uci.3,p.K161T|NM_033272,p.K161T|ENST00000328032,p.K161T|ENST00000332142,p.K161T	protein_coding, processed_transcript	uc002uci.3	nonsynonymous SNV	exon4	c.A482C	p.K161T	PIKTVNRKFFGFKFPGLRVLTYRKQ	PIKTVNRKFFGFTFPGLRVLTYRKQ	3.0	5.0	-	-	4196_2:163374650-163374650 T>G_PIKTVNRKFFGFTFPGLRVLTYRKQ	0.0
1:32119545-32119545 C>T	1.0	4071	COLORECTAL	-	-	-	-	COL16A1	ENST00000373672,p.R1486K|ENST00000271069,p.R1486K|NM_001856,p.R1486K|uc001btk.1,p.R1486K|uc001btj.1,p.R1284K	retained_intron, protein_coding, processed_transcript	uc001btk.1	nonsynonymous SNV	exon69	c.G4457A	p.R1486K	RPGPPGKDGAPGRPGAPGSPGLPGQ	RPGPPGKDGAPGKPGAPGSPGLPGQ	8.0	8.0	-	-	4071_1:32119545-32119545 C>T_RPGPPGKDGAPGKPGAPGSPGLPGQ	0.0
1:118582004-118582004 T>C	1.0	4281	COLORECTAL	-	-	-	-	SPAG17	ENST00000336338,p.D1077G|uc001ehk.2,p.D1077G|NM_206996,p.D1077G	protein_coding, processed_transcript	uc001ehk.2	nonsynonymous SNV	exon23	c.A3230G	p.D1077G	VKDNHNFMIHLNDPKEIVKKEEKGD	VKDNHNFMIHLNGPKEIVKKEEKGD	4.0	8.0	-	-	4281_1:118582004-118582004 T>C_VKDNHNFMIHLNGPKEIVKKEEKGD	0.0
15:39874718-39874718 G>A	1.0	3466	MELANOMA	-	-	-	-	THBS1	uc001zkh.3,p.S131N|NM_003246,p.S131N|ENST00000260356,p.S131N	retained_intron, protein_coding	uc001zkh.3	nonsynonymous SNV	exon3	c.G392A	p.S131N	VVSNGKAGTLDLSLTVQGKQHVVSV	VVSNGKAGTLDLNLTVQGKQHVVSV	10.0	1.0	-	-	3466_15:39874718-39874718 G>A_VVSNGKAGTLDLNLTVQGKQHVVSV	0.0
2:167056206-167056206 C>G	0.0	4258	ENDOMETRIAL	-	-	-	-	SCN9A	ENST00000303354,p.G1649A|ENST00000409672,p.G1637A|ENST00000375387,p.G1649A|NM_002977,p.G1637A|ENST00000409435,p.G1648A|uc010fpl.3,p.G1637A	retained_intron, protein_coding	uc010fpl.3	nonsynonymous SNV	exon27	c.G4910C	p.G1637A	ALMMSLPALFNIGLLLFLVMFIYAI	ALMMSLPALFNIALLLFLVMFIYAI	3.0	7.0	-	-	4258_2:167056206-167056206 C>G_ALMMSLPALFNIALLLFLVMFIYAI	0.0
16:24801460-24801460 G>A	1.0	3713	MELANOMA	-	-	-	-	TNRC6A	uc002dmm.3,p.M499I|ENST00000315183,p.M499I|NM_014494,p.M499I|uc002dmn.3,p.M246I|uc002dmo.3,p.M246I|ENST00000395799,p.M499I|uc010bxs.3,p.M246I|uc010vcc.1,p.M246I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vcc.1	nonsynonymous SNV	exon1	c.G738A	p.M246I	TMNHPQMQAPSGMNGTSLSHLSNGE	TMNHPQMQAPSGINGTSLSHLSNGE	9.0	7.0	-	-	3713_16:24801460-24801460 G>A_TMNHPQMQAPSGINGTSLSHLSNGE	0.0
22:39078045-39078045 C>T	1.0	3795	MELANOMA	-	-	-	-	TOMM22	ENST00000216034,p.P21L|NM_020243,p.P21L|uc003awe.3,p.P21L	retained_intron, protein_coding	uc003awe.3	nonsynonymous SNV	exon1	c.C62T	p.P21L	GAGEPQSPDELLPKGDAEKPEEELE	GAGEPQSPDELLLKGDAEKPEEELE	9.0	7.0	-	-	3795_22:39078045-39078045 C>T_GAGEPQSPDELLLKGDAEKPEEELE	0.0
4:49034612-49034612 T>A	1.0	4126	NSCLC	-	-	ID=COSM734253;OCCURENCE=1(lung)	-	CWH43	ENST00000226432,p.V513E|NM_025087,p.V513E|ENST00000513409,p.V486E|uc011bzl.2,p.V486E|NM_001286791,p.V486E|uc003gyv.3,p.V513E	retained_intron, protein_coding, nonsense_mediated_decay	uc011bzl.2	nonsynonymous SNV	exon12	c.T1457A	p.V486E	TWGIMALSRYPIVKSEHHLLPSPEG	TWGIMALSRYPIEKSEHHLLPSPEG	5.0	3.0	-	-	4126_4:49034612-49034612 T>A_TWGIMALSRYPIEKSEHHLLPSPEG	0.0
19:50176997-50176997 T>C	1.0	4180	BREAST	-	-	-	2	BCL2L12	uc031rlz.1,p.I258T|NM_001282521,p.I182T|uc031rlv.1,p.I182T|NM_001282519,p.I258T|uc031rma.1,p.I211T|NM_001282520,p.I211T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc031rma.1	nonsynonymous SNV	exon5	c.T632C	p.I211T	HPGCFTRGLELAIGLSSFSEAATR	HPGCFTRGLELATGLSSFSEAATR	9.0	6.0	-	-	4180_19:50176997-50176997 T>C_HPGCFTRGLELATGLSSFSEAATR	0.0
X:148585764-148585764 C>G	0.0	4129	NSCLC	-	-	-	-	IDS	uc011mxh.2,p.G55R|uc011mxj.2,p.G55R|NM_006123,p.G55R|ENST00000466323,p.G55R|ENST00000370443,p.G55R|ENST00000340855,p.G55R|NM_000202,p.G55R|ENST00000521702,p.G55R|ENST00000428056,p.G55R|ENST00000370441,p.G55R|uc011mxe.2,p.G55R	protein_coding, processed_transcript, nonsense_mediated_decay	uc011mxj.2	nonsynonymous SNV	exon2	c.G163C	p.G55R	IVDDLRPSLGCYGDKLVRSPNIDQL	IVDDLRPSLGCYRDKLVRSPNIDQL	8.0	6.0	-	-	4129_X:148585764-148585764 C>G_IVDDLRPSLGCYRDKLVRSPNIDQL	0.0
1:156235763-156235763 G>A	1.0	4126	NSCLC	-	-	-	-	SMG5	NM_015327,p.P555L|uc001foc.4,p.P555L|ENST00000361813,p.P555L	protein_coding, processed_transcript	uc001foc.4	nonsynonymous SNV	exon12	c.C1664T	p.P555L	RGRSEAPDSLNGPLGPSEASIASNL	RGRSEAPDSLNGLLGPSEASIASNL	10.0	2.0	-	-	4126_1:156235763-156235763 G>A_RGRSEAPDSLNGLLGPSEASIASNL	0.0
4:2242196-2242196 T>C	1.0	2098	MELANOMA	-	-	-	-	HAUS3	ENST00000443786,p.T160A|uc003ges.1,p.T160A|uc003get.1,p.T160A|ENST00000506763,p.T160A|NM_024511,p.T160A|ENST00000243706,p.T160A|uc011bvj.1,p.T160A	protein_coding	uc011bvj.1	nonsynonymous SNV	exon2	c.A478G	p.T160A	LKQSQGILNAMITKISNELQALTDE	LKQSQGILNAMIAKISNELQALTDE	7.0	7.0	CD8	-	2098_4:2242196-2242196 T>C_LKQSQGILNAMIAKISNELQALTDE	1.0
7:142460807-142460807 G>A	0.0	4301	MELANOMA	-	-	-	-	PRSS1	uc003wak.2,p.G227E|ENST00000486171,p.G241E|ENST00000311737,p.G227E|NM_002769,p.G227E|uc003wam.2,p.G167E	retained_intron, protein_coding	uc003wam.2	nonsynonymous SNV	exon3	c.G500A	p.G167E	SWGDGCAQKNKPGVYTKVYNYVKWI	SWGDGCAQKNKPEVYTKVYNYVKWI	4.0	10.0	-	-	4301_7:142460807-142460807 G>A_SWGDGCAQKNKPEVYTKVYNYVKWI	0.0
19:55993135-55993135 G>T	1.0	4110	BILE DUCT	-	-	-	-	ZNF628	ENST00000391718,p.R188L|uc002qld.3,p.R192L|ENST00000598519,p.R192L|NM_033113,p.R192L	protein_coding	uc002qld.3	nonsynonymous SNV	exon3	c.G575T	p.R192L	VCGKSFTQSTNLRQHQRVHTGERPF	VCGKSFTQSTNLLQHQRVHTGERPF	5.0	7.0	-	-	4110_19:55993135-55993135 G>T_VCGKSFTQSTNLLQHQRVHTGERPF	0.0
1:29016692-29016692 G>A	1.0	3903	MELANOMA	-	-	-	-	GMEB1	uc001bra.3,p.G79R|ENST00000373816,p.G69R|NM_006582,p.G79R|uc001bqz.3,p.G69R|uc001brb.3,p.G69R|NM_024482,p.G69R|ENST00000294409,p.G79R|ENST00000361872,p.G69R	protein_coding, processed_transcript	uc001brb.3	nonsynonymous SNV	exon3	c.G205A	p.G69R	AVETHTIHKIEEGIDTGTIEANEDM	AVETHTIHKIEERIDTGTIEANEDM	6.0	2.0	-	-	3903_1:29016692-29016692 G>A_AVETHTIHKIEERIDTGTIEANEDM	0.0
17:34001228-34001228 G>A	1.0	4326	BREAST	-	-	-	-	AP2B1	uc002hjs.3,p.E667K|uc002hjq.3,p.E738K|ENST00000262325,p.E724K|NM_001030006,p.E738K|ENST00000537622,p.E738K|ENST00000589344,p.E738K|ENST00000592545,p.E700K|ENST00000538556,p.E667K|uc010wci.2,p.E700K|uc002hjr.3,p.E724K|uc002hjt.3,p.E738K|ENST00000312678,p.E738K|uc010ctv.3,p.E738K|uc010wcj.2,p.E475K|NM_001282,p.E724K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wcj.2	nonsynonymous SNV	exon13	c.G1423A	p.E475K	AVWLPAVKAKGLEISGTFTHRQGHI	AVWLPAVKAKGLKISGTFTHRQGHI	9.0	4.0	-	-	4326_17:34001228-34001228 G>A_AVWLPAVKAKGLKISGTFTHRQGHI	0.0
5:140181362-140181362 C>T	1.0	3879	MELANOMA	-	-	-	-	PCDHA3	ENST00000532566,p.L194F|NM_031497,p.L194F|uc011czz.2,p.L194F|NM_018906,p.L194F|ENST00000522353,p.L194F|uc003lhf.2,p.L194F	protein_coding	uc011czz.2	nonsynonymous SNV	exon1	c.C580T	p.L194F	VKRNDEEIKSLGLVLKKNLNREDTP	VKRNDEEIKSLGFVLKKNLNREDTP	2.0	6.0	-	-	3879_5:140181362-140181362 C>T_VKRNDEEIKSLGFVLKKNLNREDTP	0.0
14:52957681-52957681 G>A	1.0	3879	MELANOMA	-	-	-	-	TXNDC16	ENST00000281741,p.L267F|uc001wzs.3,p.L267F|NM_020784,p.L267F|uc010tqu.2,p.L262F|NM_001160047,p.L262F	protein_coding, processed_transcript, nonsense_mediated_decay	uc010tqu.2	nonsynonymous SNV	exon10	c.C784T	p.L262F	VAEDPQQVSTVHLQLGLPLVFIVSQ	VAEDPQQVSTVHFQLGLPLVFIVSQ	6.0	6.0	-	-	3879_14:52957681-52957681 G>A_VAEDPQQVSTVHFQLGLPLVFIVSQ	0.0
3:15686033-15686033 C>T	1.0	3678	MELANOMA	-	-	-	-	BTD	NM_001281725,p.P204S|uc011avw.2,p.P226S|ENST00000449107,p.P226S|ENST00000303498,p.P224S|ENST00000437172,p.P226S|uc011avv.2,p.P226S|NM_001281724,p.P226S|NM_000060,p.P224S|uc003cah.3,p.P224S|ENST00000436193,p.P204S|ENST00000383778,p.P204S|NM_001281723,p.P226S|uc011avx.2,p.P204S	protein_coding, processed_transcript, nonsense_mediated_decay	uc011avx.2	nonsynonymous SNV	exon4	c.C610T	p.P204S	KHNLYFEAAFDVPLKVDLITFDTPF	KHNLYFEAAFDVSLKVDLITFDTPF	8.0	8.0	-	-	3678_3:15686033-15686033 C>T_KHNLYFEAAFDVSLKVDLITFDTPF	0.0
6:56510958-56510958 T>A	1.0	2556	MELANOMA	-	-	-	-	DST	uc021zaz.2,p.Q315L|ENST00000449297,p.Q493L|NM_001144770,p.Q355L|ENST00000520645,p.Q355L|uc003pde.2,p.Q431L|NM_183380,p.Q315L|ENST00000370754,p.Q493L|ENST00000421834,p.Q315L|uc021zay.2,p.Q355L|uc011dxl.1,p.Q344L|ENST00000312431,p.Q315L|NM_001144769,p.Q493L|uc021zba.2,p.Q493L|ENST00000370788,p.Q315L|ENST00000361203,p.Q315L|ENST00000370769,p.Q315L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zba.2	nonsynonymous SNV	exon13	c.A1478T	p.Q493L	PVELKALYNQYLQFKETEIPPKETE	PVELKALYNQYLLFKETEIPPKETE	10.0	6.0	-	-	2556_6:56510958-56510958 T>A_PVELKALYNQYLLFKETEIPPKETE	0.0
17:54431369-54431369 G>T	0.0	4240	BREAST	-	-	-	-	ANKFN1	ENST00000566473,p.R191M|NM_153228,p.R191M|uc002iun.1,p.R191M|ENST00000318698,p.R191M	retained_intron, protein_coding, processed_transcript	uc002iun.1	nonsynonymous SNV	exon5	c.G572T	p.R191M	DIAIMTNNVPIARILLRTGARESPH	DIAIMTNNVPIAMILLRTGARESPH	3.0	8.0	-	-	4240_17:54431369-54431369 G>T_DIAIMTNNVPIAMILLRTGARESPH	0.0
11:17574965-17574965 C>A	0.0	4259	COLORECTAL	-	-	-	-	OTOG	NM_001277269,p.H159N|ENST00000399397,p.H86N|uc031pzc.1,p.H159N|ENST00000399391,p.H159N|NM_001292063,p.H147N	retained_intron, protein_coding, processed_transcript	uc031pzc.1	nonsynonymous SNV	exon5	c.C475A	p.H159N	ERDSICRAWGQHHVETFDGLYYYLS	ERDSICRAWGQHNVETFDGLYYYLS	4.0	7.0	-	-	4259_11:17574965-17574965 C>A_ERDSICRAWGQHNVETFDGLYYYLS	0.0
20:50238618-50238618 G>A	1.0	2556	MELANOMA	-	-	-	-	ATP9A	uc002xwg.1,p.R704W|uc010gih.1,p.R568W|NM_006045,p.R704W|ENST00000338821,p.R704W|ENST00000311637,p.R568W|ENST00000402822,p.R583W	protein_coding, processed_transcript	uc010gih.1	nonsynonymous SNV	exon14	c.C1702T	p.R568W	HLVTRNQDIHVFRLVTNRGEAHLEL	HLVTRNQDIHVFWLVTNRGEAHLEL	8.0	7.0	-	-	2556_20:50238618-50238618 G>A_HLVTRNQDIHVFWLVTNRGEAHLEL	0.0
17:81006583-81006583 C>T	1.0	2556	MELANOMA	-	-	-	-	B3GNTL1	ENST00000320865,p.G47S|NM_001009905,p.G47S|uc002kgg.1,p.G47S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002kgg.1	nonsynonymous SNV	exon2	c.G139A	p.G47S	ECLRSVLQQDFEGTMELSVFNDASK	ECLRSVLQQDFESTMELSVFNDASK	6.0	7.0	-	-	2556_17:81006583-81006583 C>T_ECLRSVLQQDFESTMELSVFNDASK	0.0
2:207173160-207173160 C>T	0.0	4235	COLORECTAL	0.01	-	-	-	ZDBF2	uc002vbp.2,p.A1303V|NM_001285549,p.A1301V|ENST00000374423,p.A1303V|NM_020923,p.A1303V|uc031rqy.1,p.A1301V	protein_coding	uc031rqy.1	nonsynonymous SNV	exon7	c.C3902T	p.A1301V	EPLQSVTNKIPGANKEINLLREEHV	EPLQSVTNKIPGVNKEINLLREEHV	3.0	5.0	-	-	4235_2:207173160-207173160 C>T_EPLQSVTNKIPGVNKEINLLREEHV	0.0
1:60106962-60106962 G>A	0.0	3466	MELANOMA	-	-	-	-	FGGY	ENST00000371218,p.G411E|uc009wac.3,p.G411E|NM_001113411,p.G411E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc009wac.3	nonsynonymous SNV	exon12	c.G1232A	p.G411E	LADLTLKGMRTTGYLYIPALAALHS	LADLTLKGMRTTEYLYIPALAALHS	4.0	7.0	-	-	3466_1:60106962-60106962 G>A_LADLTLKGMRTTEYLYIPALAALHS	0.0
8:13424951-13424951 C>T	0.0	4284	COLORECTAL	-	-	-	-	C8orf48	uc003wwp.3,p.H151Y|ENST00000297324,p.H151Y|NM_001007090,p.H151Y	protein_coding	uc003wwp.3	nonsynonymous SNV	exon1	c.C451T	p.H151Y	SKKKTSSRHKKLHLGLDVEASERDA	SKKKTSSRHKKLYLGLDVEASERDA	2.0	5.0	-	-	4284_8:13424951-13424951 C>T_SKKKTSSRHKKLYLGLDVEASERDA	0.0
2:174227970-174227970 G>C	1.0	4284	COLORECTAL	-	-	-	-	CDCA7	ENST00000410019,p.R13P|uc010zek.1,p.R13P	retained_intron, protein_coding, nonsense_mediated_decay	uc010zek.1	nonsynonymous SNV	exon2	c.G38C	p.R13P	MDARRVPRLQSVREGCRTRSQCRHS	MDARRVPRLQSVPEGCRTRSQCRHS	10.0	7.0	-	-	4284_2:174227970-174227970 G>C_MDARRVPRLQSVPEGCRTRSQCRHS	0.0
9:32633592-32633592 G>C	0.0	3775	CERVICAL	-	-	-	-	TAF1L	NM_153809,p.I662M|ENST00000242310,p.I662M|uc003zrg.1,p.I662M	protein_coding	uc003zrg.1	nonsynonymous SNV	exon1	c.C1986G	p.I662M	PGPHSVQPLLKHIKKKAKMREQERQ	PGPHSVQPLLKHMKKKAKMREQERQ	1.0	6.0	-	-	3775_9:32633592-32633592 G>C_PGPHSVQPLLKHMKKKAKMREQERQ	0.0
10:58119539-58119539 T>G	0.0	4326	BREAST	-	-	-	-	ZWINT	ENST00000395405,p.K111T|NM_007057,p.K111T|uc001jjx.1,p.K111T|NM_001005413,p.K111T|uc001jjy.1,p.K111T|ENST00000373944,p.K111T|NM_032997,p.K111T|uc001jka.1,p.K111T|ENST00000361148,p.K111T	protein_coding, processed_transcript	uc001jka.1	nonsynonymous SNV	exon4	c.A332C	p.K111T	LKATYREHVEAIKIGLTKALTQMEE	LKATYREHVEAITIGLTKALTQMEE	7.0	2.0	-	-	4326_10:58119539-58119539 T>G_LKATYREHVEAITIGLTKALTQMEE	0.0
15:85400580-85400580 C>T	0.0	3903	MELANOMA	-	-	-	-	ALPK3	ENST00000258888,p.P1073S|uc002ble.3,p.P1073S|NM_020778,p.P1073S	retained_intron, protein_coding	uc002ble.3	nonsynonymous SNV	exon6	c.C3217T	p.P1073S	GLSQEVPTMPSLPGTGLTASPKAGP	GLSQEVPTMPSLSGTGLTASPKAGP	3.0	2.0	-	-	3903_15:85400580-85400580 C>T_GLSQEVPTMPSLSGTGLTASPKAGP	0.0
4:162376205-162376205 C>A	0.0	4110	BILE DUCT	-	-	-	-	FSTL5	NM_001128427,p.V597L|uc003iqi.4,p.V597L|NM_020116,p.V598L|ENST00000536695,p.V597L|ENST00000427802,p.V588L|NM_001128428,p.V588L|ENST00000306100,p.V598L|ENST00000379164,p.V597L|uc010iqv.4,p.V588L|uc003iqh.4,p.V598L	protein_coding, processed_transcript	uc010iqv.4	nonsynonymous SNV	exon14	c.G1762T	p.V588L	IHTQPVGKQFDRVDDFFIPTTTLII	IHTQPVGKQFDRLDDFFIPTTTLII	1.0	10.0	-	-	4110_4:162376205-162376205 C>A_IHTQPVGKQFDRLDDFFIPTTTLII	0.0
10:45984856-45984856 T>C	1.0	4186	BREAST	-	-	-	-	MARCH8	ENST00000319836,p.T38A|ENST00000453980,p.T38A|ENST00000395769,p.T38A|uc001jck.1,p.T38A|NM_001282866,p.T38A|ENST00000453424,p.T38A|NM_145021,p.T38A|uc001jch.2,p.T38A|uc001jci.1,p.T38A|NM_001002266,p.T38A|uc001jcj.1,p.T38A|ENST00000395771,p.T38A	protein_coding, processed_transcript	uc001jck.1	nonsynonymous SNV	exon3	c.A112G	p.T38A	TKEKEREEQNEKTLGHFMSHSSNIS	TKEKEREEQNEKALGHFMSHSSNIS	8.0	7.0	-	-	4186_10:45984856-45984856 T>C_TKEKEREEQNEKALGHFMSHSSNIS	0.0
4:177071010-177071010 C>A	0.0	4252	COLORECTAL	-	-	-	-	WDR17	ENST00000508596,p.D650E|ENST00000507824,p.D657E|NM_170710,p.D674E|uc003ium.4,p.D650E|NM_181265,p.D650E|ENST00000393643,p.D650E|ENST00000280190,p.D674E|uc003iuj.3,p.D674E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003ium.4	nonsynonymous SNV	exon14	c.C1950A	p.D650E	PSRPFTMASCSRDSTVRLWSLTALV	PSRPFTMASCSRESTVRLWSLTALV	3.0	10.0	-	-	4252_4:177071010-177071010 C>A_PSRPFTMASCSRESTVRLWSLTALV	0.0
6:110636575-110636575 C>T	0.0	4266	COLORECTAL	-	-	-	-	METTL24	ENST00000338882,p.R176H|NM_001123364,p.R176H|uc010kdu.1,p.R176H	protein_coding, processed_transcript	uc010kdu.1	nonsynonymous SNV	exon3	c.G527A	p.R176H	CLDDRFNLAHQIRNKQCRLYSLGLG	CLDDRFNLAHQIHNKQCRLYSLGLG	4.0	4.0	-	-	4266_6:110636575-110636575 C>T_CLDDRFNLAHQIHNKQCRLYSLGLG	0.0
6:170176735-170176735 C>T	1.0	3713	MELANOMA	-	-	-	-	ERMARD	uc011ehb.1,p.R443C|uc003qxi.1,p.R217C|ENST00000366773,p.R569C|ENST00000392095,p.R443C|ENST00000588451,p.R433C|NM_018341,p.R569C|NM_001278532,p.R443C|uc003qxg.1,p.R569C	retained_intron, protein_coding, nonsense_mediated_decay	uc011ehb.1	nonsynonymous SNV	exon15	c.C1327T	p.R443C	RHRQWVERTLRSRQRQNYLRMWSSI	RHRQWVERTLRSCQRQNYLRMWSSI	4.0	2.0	-	-	3713_6:170176735-170176735 C>T_RHRQWVERTLRSCQRQNYLRMWSSI	0.0
18:9257295-9257295 C>T	1.0	3713	MELANOMA	-	-	-	-	ANKRD12	NM_015208,p.P1344S|uc002knx.3,p.P1321S|uc002knw.3,p.P1321S|ENST00000383440,p.P1321S|NM_001083625,p.P1321S|uc010dkx.1,p.P1051S|ENST00000400020,p.P1321S|NM_001204056,p.P1321S|ENST00000262126,p.P1344S|uc002knv.3,p.P1344S	protein_coding, processed_transcript, nonsense_mediated_decay	uc010dkx.1	nonsynonymous SNV	exon4	c.C3151T	p.P1051S	QGSLLTVPGDTSPSPKPEVFSNVPE	QGSLLTVPGDTSSSPKPEVFSNVPE	8.0	2.0	-	-	3713_18:9257295-9257295 C>T_QGSLLTVPGDTSSSPKPEVFSNVPE	0.0
15:42364548-42364548 G>A	0.0	4235	COLORECTAL	-	-	-	-	PLA2G4D	uc001zox.3,p.R454W|NM_178034,p.R454W|ENST00000290472,p.R454W	retained_intron, protein_coding	uc001zox.3	nonsynonymous SNV	exon14	c.C1360T	p.R454W	DQKLSGQRAALERGQNPLPLYLSLN	DQKLSGQRAALEWGQNPLPLYLSLN	2.0	10.0	-	-	4235_15:42364548-42364548 G>A_DQKLSGQRAALEWGQNPLPLYLSLN	0.0
1:21900226-21900226 G>A	0.0	4266	COLORECTAL	-	-	-	-	ALPL	ENST00000374840,p.E311K|NM_001177520,p.E234K|ENST00000540617,p.E256K|uc010odn.2,p.E259K|uc010odo.2,p.E256K|uc001beu.4,p.E311K|NM_000478,p.E311K|ENST00000539907,p.E234K|NM_001127501,p.E256K|ENST00000374832,p.E311K|ENST00000425315,p.E311K|uc010odp.2,p.E234K|uc001bet.3,p.E311K	protein_coding, processed_transcript	uc010odp.2	nonsynonymous SNV	exon7	c.G700A	p.E234K	LNRNNVTDPSLSEMVVVAIQILRKN	LNRNNVTDPSLSKMVVVAIQILRKN	6.0	9.0	-	-	4266_1:21900226-21900226 G>A_LNRNNVTDPSLSKMVVVAIQILRKN	0.0
4:73013479-73013479 G>A	0.0	4298	COLORECTAL	-	-	-	-	NPFFR2	uc003hgg.2,p.E507K|uc010iig.2,p.E289K|uc003hgh.2,p.E405K|ENST00000308744,p.E507K|NM_053036,p.E405K|NM_001144756,p.E408K|NM_004885,p.E507K|ENST00000358749,p.E405K|ENST00000395999,p.E408K|uc003hgi.2,p.E408K	protein_coding, processed_transcript	uc010iig.2	nonsynonymous SNV	exon3	c.G865A	p.E289K	LLYRKSAEKPQQELVMEELKETTNS	LLYRKSAEKPQQKLVMEELKETTNS	3.0	8.0	-	-	4298_4:73013479-73013479 G>A_LLYRKSAEKPQQKLVMEELKETTNS	0.0
8:107670383-107670383 C>T	1.0	4110	BILE DUCT	-	-	-	-	OXR1	ENST00000435082,p.P57S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000435082	nonsynonymous SNV	exon1	c.C169T	p.P57S	QGDLGCGSPPHRPPAPSSPEGPDYY	QGDLGCGSPPHRSPAPSSPEGPDYY	8.0	7.0	-	-	4110_8:107670383-107670383 C>T_QGDLGCGSPPHRSPAPSSPEGPDYY	0.0
6:36464515-36464515 G>A	1.0	3879	MELANOMA	-	-	-	-	STK38	uc003omh.3,p.P414S|uc003omg.3,p.P414S|ENST00000229812,p.P414S|NM_007271,p.P414S|uc003omi.3,p.P414S	protein_coding	uc003omi.3	nonsynonymous SNV	exon13	c.C1240T	p.P414S	KSIDDTSNFDEFPESDILKPTVATS	KSIDDTSNFDEFSESDILKPTVATS	8.0	9.0	-	-	3879_6:36464515-36464515 G>A_KSIDDTSNFDEFSESDILKPTVATS	0.0
7:75890723-75890723 G>A	0.0	4275	COLORECTAL	-	-	ID=COSM1452099;OCCURENCE=2(large_intestine)	-	SRRM3	uc010ldi.2,p.R210H|NM_001291831,p.R210H|ENST00000388802,p.R210H|ENST00000326382,p.R210H	retained_intron, protein_coding, processed_transcript	uc010ldi.2	nonsynonymous SNV	exon7	c.G629A	p.R210H	PLRKKKKSVKKHRRDRSDSGSRRKR	PLRKKKKSVKKHHRDRSDSGSRRKR	5.0	5.0	-	-	4275_7:75890723-75890723 G>A_PLRKKKKSVKKHHRDRSDSGSRRKR	0.0
6:79657468-79657468 G>A	1.0	4258	ENDOMETRIAL	-	-	-	-	PHIP	uc003pio.4,p.P246S|uc003piq.3,p.P384S|ENST00000275034,p.P1360S|NM_017934,p.P1360S|uc003pir.3,p.P1360S|uc011dyp.2,p.P1359S	protein_coding, processed_transcript	uc011dyp.2	nonsynonymous SNV	exon36	c.C4075T	p.P1359S	LEYPDYRDIIDTPMDFATVRETLEA	LEYPDYRDIIDTSMDFATVRETLEA	9.0	7.0	-	-	4258_6:79657468-79657468 G>A_LEYPDYRDIIDTSMDFATVRETLEA	0.0
11:68192754-68192754 C>A	1.0	4234	NSCLC	-	-	-	-	LRP5	ENST00000294304,p.L1141M|uc001ont.3,p.L1141M|NM_001291902,p.L560M|NM_002335,p.L1141M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001ont.3	nonsynonymous SNV	exon15	c.C3421A	p.L1141M	VDADLKRIESCDLSGANRLTLEDAN	VDADLKRIESCDMSGANRLTLEDAN	10.0	6.0	-	-	4234_11:68192754-68192754 C>A_VDADLKRIESCDMSGANRLTLEDAN	0.0
12:56825281-56825281 C>G	1.0	4240	BREAST	-	-	-	-	TIMELESS	ENST00000553532,p.K265N|uc001slg.2,p.K264N|ENST00000229201,p.K264N|ENST00000554616,p.K265N|NM_003920,p.K265N|uc001slf.2,p.K265N	retained_intron, protein_coding	uc001slg.2	nonsynonymous SNV	exon8	c.G792C	p.K264N	LEVLRQREMAEKKTRALQRGNRHSR	LEVLRQREMAEKNTRALQRGNRHSR	9.0	8.0	-	-	4240_12:56825281-56825281 C>G_LEVLRQREMAEKNTRALQRGNRHSR	0.0
18:47376024-47376024 T>G	1.0	4246	COLORECTAL	-	-	-	-	MYO5B	ENST00000285039,p.K1410Q|ENST00000324581,p.K525Q|uc002leb.2,p.K1410Q|NM_001080467,p.K1410Q|uc002lea.2,p.K525Q	retained_intron, protein_coding, processed_transcript	uc002leb.2	nonsynonymous SNV	exon32	c.A4228C	p.K1410Q	EISRLTNENLDLKELVEKLEKNERK	EISRLTNENLDLQELVEKLEKNERK	9.0	10.0	CD8	-	4246_18:47376024-47376024 T>G_EISRLTNENLDLQELVEKLEKNERK	1.0
1:245850920-245850920 C>G	0.0	4346	COLORECTAL	-	-	-	-	KIF26B	uc001ibg.1,p.S1163R|uc001ibh.1,p.S787R|NM_018012,p.S1545R|ENST00000366518,p.S1164R|ENST00000407071,p.S1545R|uc001ibf.1,p.S1545R	retained_intron, protein_coding, processed_transcript	uc001ibh.1	nonsynonymous SNV	exon3	c.C2361G	p.S787R	KSSSLPRAFQKASRQEEPDSLSYYC	KSSSLPRAFQKARRQEEPDSLSYYC	3.0	5.0	-	-	4346_1:245850920-245850920 C>G_KSSSLPRAFQKARRQEEPDSLSYYC	0.0
5:140308192-140308192 G>T	1.0	4126	NSCLC	-	-	-	-	PCDHAC1	ENST00000409700,p.R572L|NM_018898,p.R572L|uc003lig.1,p.R572L|uc003lih.2,p.R572L|NM_031882,p.R572L|ENST00000253807,p.R572L	protein_coding	uc003lih.2	nonsynonymous SNV	exon1	c.G1715T	p.R572L	PRNGSVPVEIVPRSARTGHLVTKVV	PRNGSVPVEIVPLSARTGHLVTKVV	4.0	2.0	-	-	4126_5:140308192-140308192 G>T_PRNGSVPVEIVPLSARTGHLVTKVV	0.0
2:99012481-99012481 G>A	0.0	4275	COLORECTAL	-	-	ID=COSM1580002;OCCURENCE=1(central_nervous_system)	-	CNGA3	ENST00000393504,p.R283Q|ENST00000436404,p.R265Q|NM_001298,p.R283Q|uc002syu.3,p.R265Q|uc002syt.3,p.R283Q|NM_001079878,p.R265Q|ENST00000272602,p.R283Q|uc010fij.3,p.R287Q|ENST00000409937,p.R287Q	retained_intron, protein_coding	uc010fij.3	nonsynonymous SNV	exon8	c.G860A	p.R287Q	PEVRFNRLLKFSRLFEFFDRTETRT	PEVRFNRLLKFSQLFEFFDRTETRT	1.0	8.0	-	-	4275_2:99012481-99012481 G>A_PEVRFNRLLKFSQLFEFFDRTETRT	0.0
2:219611745-219611745 C>T	1.0	4259	COLORECTAL	-	-	-	-	TTLL4	uc010zkl.1,p.S500L|ENST00000392102,p.S665L|ENST00000258398,p.S665L|NM_014640,p.S665L|ENST00000457313,p.S500L|uc002viy.3,p.S665L	retained_intron, protein_coding, nonsense_mediated_decay	uc010zkl.1	nonsynonymous SNV	exon8	c.C1499T	p.S500L	IREHQKLNHFPGSFQIGRKDRLWRN	IREHQKLNHFPGLFQIGRKDRLWRN	9.0	10.0	-	-	4259_2:219611745-219611745 C>T_IREHQKLNHFPGLFQIGRKDRLWRN	0.0
4:47578895-47578895 G>T	1.0	4326	BREAST	-	-	-	-	ATP10D	NM_020453,p.A1158S|uc003gxk.1,p.A1158S|uc003gxl.1,p.A406S|ENST00000273859,p.A1158S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003gxl.1	nonsynonymous SNV	exon12	c.G1216T	p.A406S	WVLIFFNLLFTSAPPVIYGVLEKDV	WVLIFFNLLFTSSPPVIYGVLEKDV	9.0	2.0	-	-	4326_4:47578895-47578895 G>T_WVLIFFNLLFTSSPPVIYGVLEKDV	0.0
3:192078301-192078301 T>C	0.0	4266	COLORECTAL	-	-	-	-	FGF12	uc003fsx.3,p.R76G|NM_021032,p.R76G|ENST00000454309,p.R76G	retained_intron, protein_coding, processed_transcript	uc003fsx.3	nonsynonymous SNV	exon2	c.A226G	p.R76G	RRPEPQLKGIVTRLFSQQGYFLQMH	RRPEPQLKGIVTGLFSQQGYFLQMH	4.0	3.0	-	-	4266_3:192078301-192078301 T>C_RRPEPQLKGIVTGLFSQQGYFLQMH	0.0
21:47546145-47546145 T>C	1.0	3713	MELANOMA	-	-	-	-	COL6A2	ENST00000357838,p.C806R|NM_001849,p.C806R|ENST00000310645,p.C806R|ENST00000300527,p.C806R|uc002zia.1,p.C806R|NM_058174,p.C806R|NM_058175,p.C806R|ENST00000409416,p.C806R|ENST00000397763,p.C806R|uc002zhy.1,p.C806R|uc002zhz.1,p.C806R	retained_intron, protein_coding, processed_transcript	uc002zia.1	nonsynonymous SNV	exon26	c.T2416C	p.C806R	AEKFIDDMEDVLCPDPQIVCPDLPC	AEKFIDDMEDVLRPDPQIVCPDLPC	10.0	2.0	-	-	3713_21:47546145-47546145 T>C_AEKFIDDMEDVLRPDPQIVCPDLPC	0.0
6:99365275-99365275 C>A	1.0	3713	MELANOMA	-	-	-	-	FBXL4	ENST00000229971,p.G278V|ENST00000369244,p.G278V|NM_012160,p.G278V|uc003ppg.1,p.G278V|NM_001278716,p.G278V|uc003ppf.1,p.G278V	protein_coding	uc003ppg.1	nonsynonymous SNV	exon5	c.G833T	p.G278V	FSSAVLGEGPNNGYFDKLPYELIQL	FSSAVLGEGPNNVYFDKLPYELIQL	5.0	4.0	-	-	3713_6:99365275-99365275 C>A_FSSAVLGEGPNNVYFDKLPYELIQL	0.0
19:7975437-7975437 T>C	1.0	4000	MELANOMA	-	-	-	-	MAP2K7	uc002miv.2,p.F183L|NM_145185,p.F183L|ENST00000397979,p.F183L|uc002mit.3,p.F183L|ENST00000397983,p.F199L|uc010xkb.2,p.F183L|ENST00000545011,p.F225L|NM_001297555,p.F199L|ENST00000397981,p.F183L|NM_001297556,p.F183L|uc010dvv.3,p.F58L	retained_intron, protein_coding	uc010xkb.2	nonsynonymous SNV	exon5	c.T547C	p.F183L	LKSHDCPYIVQCFGTFITNTDVFIA	LKSHDCPYIVQCLGTFITNTDVFIA	7.0	9.0	-	-	4000_19:7975437-7975437 T>C_LKSHDCPYIVQCLGTFITNTDVFIA	0.0
17:26687593-26687593 A>C	1.0	4258	ENDOMETRIAL	-	-	-	-	TMEM199	uc010wah.1,p.Q139H|uc002hba.3,p.Q139H|ENST00000292114,p.Q139H|NM_152464,p.Q139H|ENST00000509083,p.Q139H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010wah.1	nonsynonymous SNV	exon4	c.A417C	p.Q139H	TRHGGTLSDLGKQVRSLKALVITIF	TRHGGTLSDLGKHVRSLKALVITIF	8.0	7.0	-	-	4258_17:26687593-26687593 A>C_TRHGGTLSDLGKHVRSLKALVITIF	0.0
17:1558696-1558696 C>A	1.0	4258	ENDOMETRIAL	-	-	-	-	PRPF8	uc002fte.3,p.V1979F|ENST00000304992,p.V1979F|NM_006445,p.V1979F|ENST00000572621,p.V1979F	retained_intron, protein_coding, processed_transcript	uc002fte.3	nonsynonymous SNV	exon37	c.G5935T	p.V1979F	IWPTLTDEEWIKVEVQLKDLILADY	IWPTLTDEEWIKFEVQLKDLILADY	10.0	5.0	-	-	4258_17:1558696-1558696 C>A_IWPTLTDEEWIKFEVQLKDLILADY	0.0
11:30034119-30034119 G>A	0.0	3795	MELANOMA	-	-	-	-	KCNA4	uc001msk.3,p.S36F|ENST00000328224,p.S36F|uc021qfi.1,p.S36F|NM_002233,p.S36F	protein_coding, processed_transcript	uc021qfi.1	nonsynonymous SNV	exon1	c.C107T	p.S36F	QARARERERLAHSRAAAAAAVAAAT	QARARERERLAHFRAAAAAAVAAAT	2.0	10.0	-	-	3795_11:30034119-30034119 G>A_QARARERERLAHFRAAAAAAVAAAT	0.0
19:11833375-11833375 C>T	1.0	3919	MELANOMA	-	-	-	-	ZNF823	NM_001080493,p.R325K|ENST00000431998,p.R281K|NM_017507,p.R281K|ENST00000545749,p.R143K|uc002msm.2,p.R325K|NM_001297610,p.R143K|ENST00000341191,p.R325K|uc010xmd.1,p.R143K|uc010dyi.1,p.R281K	protein_coding	uc010xmd.1	nonsynonymous SNV	exon3	c.G428A	p.R143K	FYHHTSFRRHMIRHTGDGPHKCKIC	FYHHTSFRRHMIKHTGDGPHKCKIC	3.0	2.0	-	-	3919_19:11833375-11833375 C>T_FYHHTSFRRHMIKHTGDGPHKCKIC	0.0
3:145914466-145914466 G>A	1.0	3713	MELANOMA	-	-	ID=COSM1221235;OCCURENCE=1(large_intestine)	-	PLSCR4	uc003evu.4,p.R142C|NM_001128304,p.R247C|uc010hva.3,p.R157C|NM_001128306,p.R157C|NM_001128305,p.R247C|uc010huy.3,p.R247C|ENST00000493382,p.R247C|NM_001177304,p.R142C|NM_020353,p.R247C|ENST00000460350,p.R247C|ENST00000446574,p.R247C|ENST00000433593,p.R142C|ENST00000354952,p.R247C|uc003evt.4,p.R247C|ENST00000383083,p.R157C|uc010huz.3,p.R247C	retained_intron, protein_coding	uc010hva.3	nonsynonymous SNV	exon5	c.C469T	p.R157C	IQNEKKENVMRVRGPCSTYGCGSDS	IQNEKKENVMRVCGPCSTYGCGSDS	6.0	3.0	CD8	-	3713_3:145914466-145914466 G>A_IQNEKKENVMRVCGPCSTYGCGSDS	1.0
11:598461-598461 C>T	1.0	3678	MELANOMA	-	-	-	-	PHRF1	uc009ybz.1,p.P119L|uc001lqe.3,p.P328L|ENST00000534320,p.P328L|ENST00000416188,p.P328L|uc010qwe.2,p.P324L|ENST00000264555,p.P328L|uc010qwd.2,p.P327L|uc010qwc.2,p.P328L|ENST00000413872,p.P327L|NM_020901,p.P328L|ENST00000533464,p.P324L|NM_001286581,p.P328L|NM_001286583,p.P324L|NM_001286582,p.P327L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010qwe.2	nonsynonymous SNV	exon9	c.C971T	p.P324L	VATGLSTAVYQRPLTPRTPARRKRK	VATGLSTAVYQRLLTPRTPARRKRK	7.0	7.0	-	-	3678_11:598461-598461 C>T_VATGLSTAVYQRLLTPRTPARRKRK	0.0
3:53753793-53753793 C>T	0.0	4186	BREAST	-	-	-	1	CACNA1D	NM_001128839,p.S497L|ENST00000422281,p.S497L|ENST00000350061,p.S497L|uc003dgy.5,p.S497L|NM_001128840,p.S497L|uc003dgv.5,p.S497L	retained_intron, protein_coding, processed_transcript	uc003dgy.5	nonsynonymous SNV	exon11	c.C1490T	p.S497L	NRGCCGSLCQAISKSKLSRRWRRWN	NRGCCGSLCQAILKSKLSRRWRRWN	6.0	10.0	-	-	4186_3:53753793-53753793 C>T_NRGCCGSLCQAILKSKLSRRWRRWN	0.0
6:132910294-132910294 T>C	0.0	4037	NSCLC	-	-	-	-	TAAR5	uc003qdk.2,p.R178G|NM_003967,p.R178G|ENST00000258034,p.R178G	protein_coding	uc003qdk.2	nonsynonymous SNV	exon1	c.A532G	p.R178G	TSLFLYTDVVETRLSQWLEEMPCVG	TSLFLYTDVVETGLSQWLEEMPCVG	1.0	10.0	-	-	4037_6:132910294-132910294 T>C_TSLFLYTDVVETGLSQWLEEMPCVG	0.0
2:10059834-10059834 A>T	1.0	4126	NSCLC	-	-	-	-	TAF1B	ENST00000263663,p.T484S|ENST00000396242,p.T229S|uc002qzz.3,p.T484S|NM_005680,p.T484S|uc002qzy.4,p.T484S|uc010yja.2,p.T229S|uc010exd.3,p.T229S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yja.2	nonsynonymous SNV	exon14	c.A685T	p.T229S	PSSFQFNWTEEDTDRTCFHGHSLQG	PSSFQFNWTEEDSDRTCFHGHSLQG	5.0	8.0	-	-	4126_2:10059834-10059834 A>T_PSSFQFNWTEEDSDRTCFHGHSLQG	0.0
11:68548157-68548157 T>C	1.0	4126	NSCLC	-	-	-	-	CPT1A	ENST00000265641,p.N470S|ENST00000539743,p.N470S|ENST00000540367,p.N470S|uc001oog.4,p.N470S|NM_001031847,p.N470S|NM_001876,p.N470S|uc001oof.4,p.N470S|ENST00000376618,p.N470S	protein_coding, processed_transcript, nonsense_mediated_decay	uc001oog.4	nonsynonymous SNV	exon12	c.A1409G	p.N470S	TFVVFKNGKMGLNAEHSWADAPIVA	TFVVFKNGKMGLSAEHSWADAPIVA	8.0	8.0	-	-	4126_11:68548157-68548157 T>C_TFVVFKNGKMGLSAEHSWADAPIVA	0.0
10:70765618-70765618 C>T	1.0	3903	MELANOMA	-	-	-	-	KIAA1279	ENST00000361983,p.P246S|NM_015634,p.P246S|uc001joy.3,p.P246S	protein_coding, processed_transcript	uc001joy.3	nonsynonymous SNV	exon4	c.C736T	p.P246S	TLKRQLEHNAYHPIEWAINAATLSQ	TLKRQLEHNAYHSIEWAINAATLSQ	7.0	10.0	CD8	-	3903_10:70765618-70765618 C>T_TLKRQLEHNAYHSIEWAINAATLSQ	1.0
1:109465046-109465046 G>C	1.0	4345	COLORECTAL	-	-	-	-	GPSM2	NM_013296,p.S483T|uc010ove.1,p.S483T|uc010ovc.2,p.S483T|ENST00000264126,p.S483T|ENST00000406462,p.S483T|uc010ovd.2,p.S483T	protein_coding	uc010ove.1	nonsynonymous SNV	exon13	c.G1448C	p.S483T	IDHRIPNSQRKISADTIGDEGFFDL	IDHRIPNSQRKITADTIGDEGFFDL	9.0	8.0	-	-	4345_1:109465046-109465046 G>C_IDHRIPNSQRKITADTIGDEGFFDL	0.0
9:5763635-5763637 GAA>-	1.0	4037	NSCLC	-	-	-	-	RIC1	ENST00000414202,p.870_870del|ENST00000418622,p.791_791del|uc003zjh.4,p.870_870del|uc003zjl.4,p.833_833del|ENST00000381532,p.791_791del|NM_020829,p.870_870del|ENST00000251879,p.870_870del|ENST00000449720,p.754_754del|uc003zji.4,p.870_870del|NM_001206557,p.833_833del|NM_001135920,p.870_870del|uc003zjj.1,p.333_333del	retained_intron, protein_coding, nonsense_mediated_decay	uc003zjl.4	nonframeshift deletion	exon18	c.2497_2499del	p.833_833del	PHVLELMLHEVLEEEATSREPIPDP	PHVLELMLHEVLEEATSREPIPDPL	9.0	8.0	-	-	4037_9:5763635-5763637 GAA>-_PHVLELMLHEVLEEATSREPIPDPL	0.0
1:200860714-200860714 G>T	0.0	4316	COLORECTAL	-	-	-	-	C1orf106	ENST00000367342,p.G16C|uc001gvo.4,p.G30C|NM_018265,p.G30C	protein_coding, processed_transcript	uc001gvo.4	nonsynonymous SNV	exon1	c.G88T	p.G30C	MPKLNEIPPGRAGRREARGEGRWPG	MPKLNEIPPGRACRREARGEGRWPG	7.0	8.0	-	-	4316_1:200860714-200860714 G>T_MPKLNEIPPGRACRREARGEGRWPG	0.0
7:87529601-87529601 C>T	1.0	3784	MELANOMA	-	-	-	-	DBF4	uc011khf.1,p.P16L	retained_intron, protein_coding, nonsense_mediated_decay	uc011khf.1	nonsynonymous SNV	exon8	c.C47T	p.P16L	KELVVVHKKQEKPCSPFDVDKPSSM	KELVVVHKKQEKLCSPFDVDKPSSM	8.0	5.0	-	-	3784_7:87529601-87529601 C>T_KELVVVHKKQEKLCSPFDVDKPSSM	0.0
1:40218960-40218960 C>T	1.0	3466	MELANOMA	-	-	-	-	PPIE	uc001cdx.2,p.A196V|NM_006112,p.A280V|uc001cds.2,p.A280V|ENST00000324379,p.A280V|uc010oiy.2,p.A201V|ENST00000372835,p.A229V|uc001cdt.2,p.A214V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010oiy.2	nonsynonymous SNV	exon10	c.C602T	p.A201V	VTEGLDVLRQIEAQGSKDGKPKQKV	VTEGLDVLRQIEVQGSKDGKPKQKV	8.0	6.0	-	-	3466_1:40218960-40218960 C>T_VTEGLDVLRQIEVQGSKDGKPKQKV	0.0
1:151384205-151384205 G>A	1.0	3713	MELANOMA	-	-	-	-	POGZ	uc021oyq.1,p.H555Y|uc010pdc.2,p.H546Y|uc001eyf.2,p.H564Y|NM_001194938,p.H546Y|ENST00000409503,p.H599Y|ENST00000392723,p.H555Y|uc001eyd.2,p.H608Y|ENST00000491586,p.H564Y|uc010pdd.2,p.H99Y|ENST00000368863,p.H513Y|ENST00000361398,p.H555Y|NM_207171,p.H555Y|NM_015100,p.H608Y|NM_001194937,p.H599Y|uc010pdb.2,p.H599Y|NM_145796,p.H513Y|ENST00000531094,p.H546Y|uc009wmv.2,p.H513Y|ENST00000271715,p.H608Y	retained_intron, protein_coding, nonsense_mediated_decay	uc021oyq.1	nonsynonymous SNV	exon10	c.C1663T	p.H555Y	QYRSSLYSEVDVHFRMIHEDTRHLL	QYRSSLYSEVDVYFRMIHEDTRHLL	10.0	8.0	-	-	3713_1:151384205-151384205 G>A_QYRSSLYSEVDVYFRMIHEDTRHLL	0.0
20:34143853-34143853 C>T	1.0	3879	MELANOMA	-	-	-	-	ERGIC3	ENST00000357394,p.P261L|uc002xct.3,p.P256L|ENST00000279052,p.P261L|NM_198398,p.P261L|ENST00000447986,p.P271L|NM_015966,p.P256L|ENST00000348547,p.P256L|uc002xcs.3,p.P261L|uc010zvg.2,p.P256L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010zvg.2	nonsynonymous SNV	exon9	c.C767T	p.P256L	HYIQHLSFGEDYPGIVNPLDHTNVT	HYIQHLSFGEDYLGIVNPLDHTNVT	9.0	3.0	-	-	3879_20:34143853-34143853 C>T_HYIQHLSFGEDYLGIVNPLDHTNVT	0.0
19:35786711-35786711 T>C	0.0	4158	COLORECTAL	-	-	-	-	MAG	uc002nyz.2,p.V81A|NM_002361,p.V81A|NM_001199216,p.V56A|ENST00000595791,p.V81A|uc010eds.2,p.V56A|uc002nyx.2,p.V81A|ENST00000537831,p.V56A|ENST00000361922,p.V81A|NM_080600,p.V81A|ENST00000392213,p.V81A|ENST00000600291,p.V56A|uc002nyy.2,p.V81A	retained_intron, protein_coding, processed_transcript	uc010eds.2	nonsynonymous SNV	exon4	c.T167C	p.V56A	YPPVVFKSRTQVVHESFQGRSRLLG	YPPVVFKSRTQVAHESFQGRSRLLG	3.0	10.0	-	-	4158_19:35786711-35786711 T>C_YPPVVFKSRTQVAHESFQGRSRLLG	0.0
15:40750931-40750931 G>A	1.0	4298	COLORECTAL	-	-	-	-	BAHD1	uc001zlv.2,p.D90N|ENST00000560846,p.D90N|ENST00000416165,p.D90N|uc010bbp.1,p.D90N|NM_014952,p.D90N|NM_001301132,p.D90N|ENST00000561234,p.D90N|uc001zlt.2,p.D90N|uc001zlu.2,p.D90N	retained_intron, protein_coding	uc010bbp.1	nonsynonymous SNV	exon2	c.G268A	p.D90N	ENVAGPRSADEADELPPDLPKPPSP	ENVAGPRSADEANELPPDLPKPPSP	6.0	1.0	-	-	4298_15:40750931-40750931 G>A_ENVAGPRSADEANELPPDLPKPPSP	0.0
2:1481186-1481186 G>C	0.0	3775	CERVICAL	-	-	-	-	TPO	uc002qwu.3,p.G383A|NM_175719,p.G383A|ENST00000346956,p.G383A|ENST00000345913,p.G383A|NM_000547,p.G383A|ENST00000382201,p.G383A|ENST00000329066,p.G383A|NM_175721,p.G383A|ENST00000422464,p.G312A|uc002qwx.3,p.G383A|uc002qwr.3,p.G383A|uc002qww.3,p.G383A|NM_001206744,p.G383A|NM_001206745,p.G383A|uc010yip.2,p.G383A|ENST00000337415,p.G383A	protein_coding, processed_transcript	uc010yip.2	nonsynonymous SNV	exon7	c.G1148C	p.G383A	APAACAPEPGIPGETRGPCFLAGDG	APAACAPEPGIPAETRGPCFLAGDG	1.0	6.0	-	-	3775_2:1481186-1481186 G>C_APAACAPEPGIPAETRGPCFLAGDG	0.0
1:94643219-94643219 C>T	1.0	3713	MELANOMA	-	-	-	-	ARHGAP29	uc001dqj.4,p.E952K|ENST00000260526,p.E952K|ENST00000552844,p.E952K|uc001dqk.3,p.E518K|NM_004815,p.E952K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001dqk.3	nonsynonymous SNV	exon10	c.G1552A	p.E518K	ESKIFERATSFEESERKQNALGKCD	ESKIFERATSFEKSERKQNALGKCD	3.0	3.0	-	-	3713_1:94643219-94643219 C>T_ESKIFERATSFEKSERKQNALGKCD	0.0
7:142627446-142627446 C>T	0.0	3903	MELANOMA	-	-	-	-	TRPV5	ENST00000439304,p.R69K|ENST00000265310,p.R75K|uc003wby.1,p.R75K|NM_019841,p.R75K|ENST00000442623,p.R75K|uc003wbz.3,p.R75K	protein_coding	uc003wbz.3	nonsynonymous SNV	exon2	c.G224A	p.R75K	QLLLDCTCDVRQRGALGETALHIAA	QLLLDCTCDVRQKGALGETALHIAA	1.0	5.0	-	-	3903_7:142627446-142627446 C>T_QLLLDCTCDVRQKGALGETALHIAA	0.0
5:70805549-70805549 C>G	1.0	4196	COLORECTAL	-	-	-	-	BDP1	ENST00000358731,p.T877S|uc003kbp.1,p.T877S|uc003kbo.3,p.T877S|uc003kbn.1,p.T877S|NM_018429,p.T877S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003kbp.1	nonsynonymous SNV	exon17	c.C2630G	p.T877S	INTKEMQSDLKETGRRAISPREKIL	INTKEMQSDLKESGRRAISPREKIL	9.0	7.0	-	-	4196_5:70805549-70805549 C>G_INTKEMQSDLKESGRRAISPREKIL	0.0
6:42974688-42974688 A>C	1.0	4320	COLORECTAL	-	-	-	-	PPP2R5D	NM_180976,p.K89T|ENST00000394110,p.K89T|uc021yzq.2,p.K89T	retained_intron, protein_coding, nonsense_mediated_decay	uc021yzq.2	nonsynonymous SNV	exon4	c.A266C	p.K89T	GPQIVKKELFIQKLRQCCVLFDFVS	GPQIVKKELFIQTLRQCCVLFDFVS	9.0	3.0	-	-	4320_6:42974688-42974688 A>C_GPQIVKKELFIQTLRQCCVLFDFVS	0.0
8:144993596-144993596 G>T	1.0	4095	COLORECTAL	-	-	-	-	PLEC	ENST00000345136,p.L3465M|uc003zaf.1,p.L3602M|uc003zad.2,p.L3465M|ENST00000322810,p.L3602M|NM_201381,p.L3433M|ENST00000354958,p.L3443M|NM_000445,p.L3492M|ENST00000436759,p.L3492M|ENST00000354589,p.L3465M|uc003zaj.2,p.L3492M|NM_201378,p.L3451M|uc003zac.1,p.L3469M|NM_201384,p.L3465M|NM_201382,p.L3465M|NM_201383,p.L3469M|ENST00000356346,p.L3451M|uc003zah.2,p.L3451M|ENST00000398774,p.L3433M|uc003zae.1,p.L3433M|uc003zag.1,p.L3443M|NM_201379,p.L3443M|uc003zab.1,p.L3465M|ENST00000357649,p.L3469M|ENST00000527096,p.L3488M|NM_201380,p.L3602M	retained_intron, protein_coding	uc003zaj.2	nonsynonymous SNV	exon33	c.C10474A	p.L3492M	KGLVLRQHGIRLLEAQIATGGIIDP	KGLVLRQHGIRLMEAQIATGGIIDP	8.0	9.0	-	-	4095_8:144993596-144993596 G>T_KGLVLRQHGIRLMEAQIATGGIIDP	0.0
17:3422064-3422064 C>T	1.0	4196	COLORECTAL	-	-	-	-	TRPV3	uc010vrl.2,p.E615K|uc010vrh.2,p.E615K|uc002fvr.3,p.E631K|ENST00000572519,p.E631K|ENST00000301365,p.E631K|uc010vrj.2,p.E615K|ENST00000576742,p.E631K|NM_001258205,p.E631K|uc010vri.2,p.E586K|uc002fvu.3,p.E631K|uc002fvt.2,p.E631K|NM_145068,p.E631K	retained_intron, protein_coding, nonsense_mediated_decay	uc010vrl.2	nonsynonymous SNV	exon14	c.G1843A	p.E615K	CSSYGSFSDAVLELFKLTIGLGDLN	CSSYGSFSDAVLKLFKLTIGLGDLN	6.0	9.0	-	-	4196_17:3422064-3422064 C>T_CSSYGSFSDAVLKLFKLTIGLGDLN	0.0
19:57325872-57325872 G>A	0.0	3903	MELANOMA	-	-	-	-	PEG3	ENST00000598410,p.S1189F|uc010etr.2,p.S1313F|ENST00000423103,p.S1313F|NM_001146185,p.S1187F|uc002qnv.2,p.S1313F|ENST00000593695,p.S1187F|ENST00000326441,p.S1313F|NM_006210,p.S1313F|uc002qnw.2,p.S1189F|NM_001146187,p.S1189F|uc002qnu.2,p.S1313F|ENST00000599577,p.S1313F|NM_001146184,p.S1313F|uc002qnt.2,p.S1284F|ENST00000599534,p.S1313F|NM_001146186,p.S1313F|uc002qnx.2,p.S1187F	protein_coding, processed_transcript	uc010etr.2	nonsynonymous SNV	exon9	c.C3938T	p.S1313F	VTVHKNEPYEYGSSYTHTSFLTEPL	VTVHKNEPYEYGFSYTHTSFLTEPL	1.0	4.0	-	-	3903_19:57325872-57325872 G>A_VTVHKNEPYEYGFSYTHTSFLTEPL	0.0
13:58206985-58206985 G>A	0.0	4246	COLORECTAL	-	-	-	-	PCDH17	ENST00000484979,p.C102Y|uc010aec.1,p.C102Y|ENST00000377918,p.C102Y|NM_001040429,p.C102Y|uc001vhq.1,p.C102Y	protein_coding, nonsense_mediated_decay	uc010aec.1	nonsynonymous SNV	exon1	c.G305A	p.C102Y	IDRESLCRHNAKCQLSLEVFANDKE	IDRESLCRHNAKYQLSLEVFANDKE	7.0	1.0	-	-	4246_13:58206985-58206985 G>A_IDRESLCRHNAKYQLSLEVFANDKE	0.0
20:34067959-34067959 C>T	1.0	4000	MELANOMA	-	-	-	-	CEP250	ENST00000342580,p.R859W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000342580	nonsynonymous SNV	exon20	c.C2575T	p.R859W	QKAAHEKEVNQLREKWMQLETEKER	QKAAHEKEVNQLWEKWMQLETEKER	8.0	3.0	-	-	4000_20:34067959-34067959 C>T_QKAAHEKEVNQLWEKWMQLETEKER	0.0
5:13811836-13811836 A>C	0.0	4238	COLORECTAL	-	-	ID=COSM3357856;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	-	DNAH5	uc003jfd.2,p.L2443V|NM_001369,p.L2443V|ENST00000265104,p.L2443V	retained_intron, protein_coding, processed_transcript	uc003jfd.2	nonsynonymous SNV	exon44	c.T7327G	p.L2443V	SFPDLYRFCIQNLEYKMEVLEAFVI	SFPDLYRFCIQNVEYKMEVLEAFVI	3.0	5.0	-	-	4238_5:13811836-13811836 A>C_SFPDLYRFCIQNVEYKMEVLEAFVI	0.0
11:62639124-62639124 A>C	1.0	4136	BREAST	-	-	-	-	SLC3A2	ENST00000377892,p.K94T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000377892	nonsynonymous SNV	exon3	c.A281C	p.K94T	LLASSDPPALASKNAEVTETGFHHV	LLASSDPPALASTNAEVTETGFHHV	10.0	7.0	-	-	4136_11:62639124-62639124 A>C_LLASSDPPALASTNAEVTETGFHHV	0.0
3:27244025-27244025 G>A	0.0	4238	COLORECTAL	-	-	-	-	LRRC3B,NEK10	ENST00000357467,p.P102L|uc003cds.1,p.P102L|ENST00000429845,p.P705L	retained_intron, protein_coding, processed_transcript	uc003cds.1	nonsynonymous SNV	exon7	c.C305T	p.P102L	ILYSCPEVLKSEPYGEKADVWAVGC	ILYSCPEVLKSELYGEKADVWAVGC	1.0	7.0	-	-	4238_3:27244025-27244025 G>A_ILYSCPEVLKSELYGEKADVWAVGC	0.0
19:48997234-48997234 G>A	0.0	4266	COLORECTAL	-	-	-	-	LMTK3	NM_001080434,p.A1299V|ENST00000270238,p.A1299V|uc002pjk.3,p.A1299V|ENST00000600059,p.A1270V	protein_coding	uc002pjk.3	nonsynonymous SNV	exon13	c.C3896T	p.A1299V	AGAAGGEAGGAGAPGPAEEDGEDED	AGAAGGEAGGAGVPGPAEEDGEDED	4.0	7.0	-	-	4266_19:48997234-48997234 G>A_AGAAGGEAGGAGVPGPAEEDGEDED	0.0
12:104698472-104698472 C>T	1.0	3879	MELANOMA	-	-	-	-	EID3	NM_001008394,p.R254C|uc001tkw.3,p.R254C|ENST00000527879,p.R254C	protein_coding	uc001tkw.3	nonsynonymous SNV	exon1	c.C760T	p.R254C	YFEFVIDPNSFSRTVENIFYVSFIV	YFEFVIDPNSFSCTVENIFYVSFIV	4.0	9.0	-	-	3879_12:104698472-104698472 C>T_YFEFVIDPNSFSCTVENIFYVSFIV	0.0
10:5541098-5541098 C>T	1.0	4301	MELANOMA	-	-	-	-	CALML5	uc001iic.2,p.E102K|NM_017422,p.E102K|ENST00000380332,p.E102K	protein_coding	uc001iic.2	nonsynonymous SNV	exon1	c.G304A	p.E102K	FDQDGDGHITVDELRRAMAGLGQPL	FDQDGDGHITVDKLRRAMAGLGQPL	4.0	7.0	-	-	4301_10:5541098-5541098 C>T_FDQDGDGHITVDKLRRAMAGLGQPL	0.0
10:99640110-99640110 C>T	1.0	3678	MELANOMA	0.0009	-	-	-	CRTAC1	ENST00000298819,p.E558K|ENST00000413387,p.E454K|uc001kot.2,p.E348K	protein_coding, processed_transcript	uc001kot.2	nonsynonymous SNV	exon11	c.G1042A	p.E348K	PMNASSSHSCALETSPYVSTPMEAT	PMNASSSHSCALKTSPYVSTPMEAT	7.0	10.0	-	-	3678_10:99640110-99640110 C>T_PMNASSSHSCALKTSPYVSTPMEAT	0.0
X:153284442-153284442 G>T	0.0	4258	ENDOMETRIAL	-	-	-	-	IRAK1	ENST00000444230,p.A171D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000444230	nonsynonymous SNV	exon4	c.C512A	p.A171D	SPASLWPPPPSPAPSSTKQDPVSKR	SPASLWPPPPSPDPSSTKQDPVSKR	10.0	3.0	-	-	4258_X:153284442-153284442 G>T_SPASLWPPPPSPDPSSTKQDPVSKR	0.0
1:158627473-158627473 C>A	0.0	4081	COLORECTAL	-	-	-	-	SPTA1	ENST00000368148,p.A867S|uc001fst.1,p.A867S|ENST00000368147,p.A867S|NM_003126,p.A867S	protein_coding, processed_transcript	uc001fst.1	nonsynonymous SNV	exon19	c.G2599T	p.A867S	RGNKMVEEGHFAAEDVASRVKSLNQ	RGNKMVEEGHFASEDVASRVKSLNQ	1.0	10.0	-	-	4081_1:158627473-158627473 C>A_RGNKMVEEGHFASEDVASRVKSLNQ	0.0
16:82101843-82101843 G>A	0.0	4246	COLORECTAL	-	-	ID=COSM1380122;OCCURENCE=1(large_intestine)	-	HSD17B2	uc002fgv.3,p.G112R|ENST00000199936,p.G112R|NM_002153,p.G112R|ENST00000569351,p.G40R	protein_coding, TEC	uc002fgv.3	nonsynonymous SNV	exon2	c.G334A	p.G112R	KYLDELGFTVFAGVLNENGPGAEEL	KYLDELGFTVFARVLNENGPGAEEL	6.0	9.0	-	-	4246_16:82101843-82101843 G>A_KYLDELGFTVFARVLNENGPGAEEL	0.0
3:51697372-51697372 T>C	1.0	4155	MELANOMA	-	-	-	-	RAD54L2	uc003dbh.3,p.V1036A|uc011bdt.2,p.V1447A|ENST00000409535,p.V1447A|uc011bdu.2,p.V1141A|ENST00000296477,p.V1141A|uc003dbj.3,p.V773A|NM_015106,p.V1447A	retained_intron, protein_coding	uc011bdu.2	nonsynonymous SNV	exon18	c.T3422C	p.V1141A	QVPPFDSHEVAEVGFSSNDDEDKDD	QVPPFDSHEVAEAGFSSNDDEDKDD	8.0	9.0	-	-	4155_3:51697372-51697372 T>C_QVPPFDSHEVAEAGFSSNDDEDKDD	0.0
5:149429853-149429853 T>G	1.0	2556	MELANOMA	-	-	-	-	HMGXB3	ENST00000502717,p.S1080R|NM_014983,p.S1080R|ENST00000503427,p.S1048R|uc003lrk.4,p.S1080R	retained_intron, protein_coding, nonsense_mediated_decay	uc003lrk.4	nonsynonymous SNV	exon19	c.T3240G	p.S1080R	VVCGSKYLVRGESARDHVDLLASSR	VVCGSKYLVRGERARDHVDLLASSR	9.0	5.0	-	-	2556_5:149429853-149429853 T>G_VVCGSKYLVRGERARDHVDLLASSR	0.0
2:27800388-27800388 G>C	0.0	4149	OVARIAN	-	-	-	-	C2orf16	uc002rkz.4,p.E317Q|ENST00000408964,p.E317Q|NM_032266,p.E317Q	protein_coding	uc002rkz.4	nonsynonymous SNV	exon1	c.G949C	p.E317Q	AERSPRLCPQNLECVEVISEKRLQG	AERSPRLCPQNLQCVEVISEKRLQG	1.0	1.0	-	-	4149_2:27800388-27800388 G>C_AERSPRLCPQNLQCVEVISEKRLQG	0.0
5:64483845-64483845 C>T	1.0	4326	BREAST	-	-	-	-	ADAMTS6	ENST00000381055,p.E970K|NM_197941,p.E970K|uc003jtp.3,p.E970K|uc003jto.4,p.E526K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003jtp.3	nonsynonymous SNV	exon22	c.G2908A	p.E970K	SCPPQWVALDWSECTPKCGPGFKHR	SCPPQWVALDWSKCTPKCGPGFKHR	6.0	10.0	-	-	4326_5:64483845-64483845 C>T_SCPPQWVALDWSKCTPKCGPGFKHR	0.0
15:84651106-84651106 G>T	0.0	4246	COLORECTAL	-	-	-	-	ADAMTSL3	uc002bjz.4,p.R909M|ENST00000286744,p.R909M|NM_001301110,p.R909M|uc010bmt.1,p.R909M|NM_207517,p.R909M|ENST00000567476,p.R909M	retained_intron, protein_coding, processed_transcript	uc010bmt.1	nonsynonymous SNV	exon21	c.G2726T	p.R909M	QILSVQRVYIQTREEKRINLTIGSR	QILSVQRVYIQTMEEKRINLTIGSR	5.0	8.0	-	-	4246_15:84651106-84651106 G>T_QILSVQRVYIQTMEEKRINLTIGSR	0.0
7:75611613-75611613 G>A	1.0	4071	COLORECTAL	-	-	-	-	POR	ENST00000419840,p.R82Q|ENST00000450476,p.R167Q|ENST00000394893,p.R268Q|uc011kgc.2,p.R76Q|ENST00000545601,p.R76Q|uc003udy.3,p.R268Q|ENST00000461988,p.R268Q|NM_000941,p.R268Q	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011kgc.2	nonsynonymous SNV	exon3	c.G227A	p.R76Q	IDAAKVYMGEMGRLKSYENQKPPFD	IDAAKVYMGEMGQLKSYENQKPPFD	10.0	7.0	CD8	-	4071_7:75611613-75611613 G>A_IDAAKVYMGEMGQLKSYENQKPPFD	2.0
7:82582375-82582375 G>A	1.0	2369	MELANOMA	-	-	-	-	PCLO	NM_014510,p.P2632S|ENST00000333891,p.P2632S|uc003uhv.2,p.P2632S|NM_033026,p.P2632S|ENST00000423517,p.P2632S|uc003uhx.2,p.P2632S	protein_coding, processed_transcript, nonsense_mediated_decay	uc003uhx.2	nonsynonymous SNV	exon5	c.C7894T	p.P2632S	FSVVPPVTAVEIPISSEQTFYISGA	FSVVPPVTAVEISISSEQTFYISGA	10.0	8.0	-	-	2369_7:82582375-82582375 G>A_FSVVPPVTAVEISISSEQTFYISGA	0.0
16:83712033-83712033 C>T	0.0	4069	PANCREATIC	-	-	-	-	CDH13	NM_001257,p.T502M|ENST00000428848,p.T463M|uc010vnu.2,p.T463M|NM_001220489,p.T463M|uc002fgx.3,p.T502M|uc010vns.2,p.T549M|NM_001220490,p.T248M|ENST00000268613,p.T549M|NM_001220488,p.T549M|ENST00000566620,p.T502M|uc010vnt.2,p.T248M	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010vnu.2	nonsynonymous SNV	exon9	c.C1388T	p.T463M	LSVGSVLLTVNATDPDSLQHQTIRY	LSVGSVLLTVNAMDPDSLQHQTIRY	8.0	7.0	-	-	4069_16:83712033-83712033 C>T_LSVGSVLLTVNAMDPDSLQHQTIRY	0.0
19:58868496-58868496 T>G	1.0	4071	COLORECTAL	-	-	-	-	ZNF497	NM_001207009,p.K169T|ENST00000425453,p.K169T|NM_198458,p.K169T|uc002qsh.2,p.K169T|uc021vcw.1,p.K169T|uc002qsi.2,p.K169T|ENST00000311044,p.K169T	protein_coding	uc021vcw.1	nonsynonymous SNV	exon1	c.A506C	p.K169T	SGEKPYACRECGKAFRAHSQLIHHQ	SGEKPYACRECGTAFRAHSQLIHHQ	2.0	4.0	-	-	4071_19:58868496-58868496 T>G_SGEKPYACRECGTAFRAHSQLIHHQ	0.0
2:40657293-40657293 C>T	1.0	3713	MELANOMA	-	-	-	-	SLC8A1	NM_021097,p.G43E|ENST00000402441,p.G43E|ENST00000542024,p.G43E|ENST00000406391,p.G43E|NM_001252624,p.G43E|ENST00000448531,p.G43E|ENST00000455476,p.G43E|NM_001112801,p.G43E|NM_001112800,p.G43E|uc002rsc.1,p.G43E|uc002rrx.3,p.G43E|ENST00000417271,p.G43E|uc002rrz.3,p.G43E|NM_001112802,p.G43E|uc010fan.1,p.G43E|uc002rry.3,p.G43E|uc002rsa.3,p.G43E|ENST00000408028,p.G43E|ENST00000407929,p.G40E|ENST00000403092,p.G43E|ENST00000542756,p.G43E|ENST00000406785,p.G43E|uc002rsb.2,p.G43E|ENST00000405269,p.G43E|ENST00000405901,p.G43E|ENST00000332839,p.G43E|uc002rsd.4,p.G43E	protein_coding, nonsense_mediated_decay	uc010fan.1	nonsynonymous SNV	exon3	c.G128A	p.G43E	DHVIAETEMEGEGNETGECTGSYYC	DHVIAETEMEGEENETGECTGSYYC	4.0	6.0	-	-	3713_2:40657293-40657293 C>T_DHVIAETEMEGEENETGECTGSYYC	0.0
7:55214300-55214309 AATCCTGCAT>-	0.0	4259	COLORECTAL	-	-	-	1	EGFR	uc022adm.1,p.E142fs|NM_201284,p.E142fs|NM_201283,p.E142fs|NM_201282,p.E142fs|ENST00000442591,p.E142fs|uc003tqi.3,p.E142fs|NM_005228,p.E142fs|ENST00000275493,p.E142fs|ENST00000450046,p.E89fs|ENST00000420316,p.E142fs|ENST00000342916,p.E142fs|uc003tqh.3,p.E142fs|uc003tqk.3,p.E142fs|uc011kco.2,p.E89fs|uc003tqj.3,p.E142fs|ENST00000344576,p.E142fs|ENST00000454757,p.E89fs	retained_intron, protein_coding, processed_transcript	uc022adm.1	frameshift deletion	exon4	c.426_435del	p.E142fs	TGLKELPMRNLQEILHGAVRFSNNP	TGLKELPMRNLQEAPCGSATTLPCATWRASSGGT	7.0	6.0	-	-	4259_7:55214300-55214309 AATCCTGCAT>-_TGLKELPMRNLQEAPCGSATTLPCATWRASSGGT	0.0
11:119599204-119599204 C>G	1.0	4281	COLORECTAL	-	-	-	-	PVRL1	NM_203286,p.L20F|uc001pwv.3,p.L20F|NM_002855,p.L20F|ENST00000340882,p.L20F|ENST00000264025,p.L20F|uc001pwu.1,p.L20F|uc001pww.3,p.L20F|NM_203285,p.L20F|ENST00000341398,p.L20F	retained_intron, protein_coding, processed_transcript	uc001pww.3	nonsynonymous SNV	exon1	c.G60C	p.L20F	GAAGRWWGLALGLTAFFLPGVHSQV	GAAGRWWGLALGFTAFFLPGVHSQV	9.0	3.0	-	-	4281_11:119599204-119599204 C>G_GAAGRWWGLALGFTAFFLPGVHSQV	0.0
19:11596534-11596534 G>A	1.0	4155	MELANOMA	-	-	-	-	ZNF653	ENST00000293771,p.P503S|NM_138783,p.P503S|uc002mrz.2,p.P503S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002mrz.2	nonsynonymous SNV	exon7	c.C1507T	p.P503S	VHRKGKTKVCPHPGCGKKFYLSNHL	VHRKGKTKVCPHSGCGKKFYLSNHL	8.0	6.0	-	-	4155_19:11596534-11596534 G>A_VHRKGKTKVCPHSGCGKKFYLSNHL	0.0
18:33734937-33734937 C>T	1.0	3879	MELANOMA	-	-	-	-	ELP2	ENST00000351393,p.P391L|ENST00000350494,p.P412L|NM_001242876,p.P412L|ENST00000539560,p.P417L|NM_001242875,p.P482L|ENST00000442325,p.P482L|ENST00000423854,p.P347L|uc002kzm.2,p.P391L|uc002kzn.2,p.P347L|uc002kzo.2,p.P347L|ENST00000542824,p.P347L|uc002kzk.2,p.P417L|NM_001242879,p.P347L|NM_001242878,p.P347L|ENST00000358232,p.P417L|uc010xch.2,p.P412L|uc010xcg.2,p.P482L|NM_001242877,p.P391L|NM_018255,p.P417L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xch.2	nonsynonymous SNV	exon11	c.C1235T	p.P412L	TVGTDQTTRLFAPWKRKDQSQVTWH	TVGTDQTTRLFALWKRKDQSQVTWH	10.0	9.0	-	-	3879_18:33734937-33734937 C>T_TVGTDQTTRLFALWKRKDQSQVTWH	0.0
19:46145475-46145475 G>A	0.0	4278	COLORECTAL	-	-	-	-	EML2	NM_001193268,p.A103V|ENST00000588172,p.A37V|NM_001193269,p.A49V|uc010xxl.2,p.A49V|ENST00000536630,p.A49V|ENST00000399594,p.A60V|ENST00000587152,p.A103V|uc010ekl.3,p.A103V|uc010xxm.2,p.A103V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010xxm.2	nonsynonymous SNV	exon2	c.C308T	p.A103V	KAALADALRRLRACEEQGAALRARG	KAALADALRRLRVCEEQGAALRARG	9.0	8.0	-	-	4278_19:46145475-46145475 G>A_KAALADALRRLRVCEEQGAALRARG	0.0
7:148768038-148768038 A>G	0.0	4345	COLORECTAL	-	-	-	-	ZNF786	NM_152411,p.L609P|ENST00000491431,p.L609P|uc003wfi.2,p.L523P|uc011kuk.1,p.L572P|ENST00000316286,p.L523P|ENST00000451334,p.L572P|uc003wfh.2,p.L609P	protein_coding	uc011kuk.1	nonsynonymous SNV	exon5	c.T1715C	p.L572P	ECNRSFRLKGQLLSHQRLHTGERPF	ECNRSFRLKGQLPSHQRLHTGERPF	4.0	1.0	-	-	4345_7:148768038-148768038 A>G_ECNRSFRLKGQLPSHQRLHTGERPF	0.0
9:37442285-37442290 GGTGGA>-	0.0	4077	BILE DUCT	-	-	-	-	ZBTB5	NM_014872,p.87_88del|uc003zzx.3,p.87_88del|ENST00000307750,p.87_88del|uc022bgv.1,p.87_88del	protein_coding	uc022bgv.1	nonframeshift deletion	exon1	c.259_264del	p.87_88del	EAFAALIDMMYTSTLMLGESNVMDV	EAFAALIDMMYTLMLGESNVMDVLL	6.0	8.0	-	-	4077_9:37442285-37442290 GGTGGA>-_EAFAALIDMMYTLMLGESNVMDVLL	0.0
X:9000386-9000386 T>A	0.0	4266	COLORECTAL	-	-	-	-	FAM9B	uc004csh.3,p.T94S|ENST00000362066,p.T94S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc004csh.3	nonsynonymous SNV	exon2	c.A280T	p.T94S	GEREPFAETDEHTGANTKKPEDTAV	GEREPFAETDEHSGANTKKPEDTAV	1.0	3.0	-	-	4266_X:9000386-9000386 T>A_GEREPFAETDEHSGANTKKPEDTAV	0.0
12:49445335-49445335 G>T	0.0	3466	MELANOMA	-	-	-	1	KMT2D	uc001rta.4,p.P711T|ENST00000301067,p.P711T|NM_003482,p.P711T	retained_intron, protein_coding, processed_transcript	uc001rta.4	nonsynonymous SNV	exon10	c.C2131A	p.P711T	SPPPEDSPASPPPEDSLMSLPLEES	SPPPEDSPASPPTEDSLMSLPLEES	8.0	9.0	-	-	3466_12:49445335-49445335 G>T_SPPPEDSPASPPTEDSLMSLPLEES	0.0
14:21822662-21822662 G>A	1.0	3713	MELANOMA	-	-	-	-	SUPT16H	ENST00000216297,p.L900F|uc001wao.2,p.L900F|NM_007192,p.L900F	retained_intron, protein_coding, nonsense_mediated_decay	uc001wao.2	nonsynonymous SNV	exon23	c.C2698T	p.L900F	SCDLKYTEGVQSLNWTKIMKTIVDD	SCDLKYTEGVQSFNWTKIMKTIVDD	10.0	2.0	-	-	3713_14:21822662-21822662 G>A_SCDLKYTEGVQSFNWTKIMKTIVDD	0.0
12:97023888-97023888 T>C	0.0	4245	COLORECTAL	-	-	-	-	CDK17,NEDD1	uc001ter.1,p.L354P|uc001tes.3,p.L48P	retained_intron, protein_coding, processed_transcript	uc001tes.3	nonsynonymous SNV	exon4	c.T143C	p.L48P	VHDFLKRRNESLLGLIKVKYKDSAL	VHDFLKRRNESLPGLIKVKYKDSAL	3.0	1.0	-	-	4245_12:97023888-97023888 T>C_VHDFLKRRNESLPGLIKVKYKDSAL	0.0
6:166844023-166844023 C>T	0.0	4246	COLORECTAL	-	-	ID=COSM595032,COSM595033;OCCURENCE=1(lung)	-	RPS6KA2	NM_001006932,p.R508Q|uc003qvb.1,p.R500Q|uc003qvd.1,p.R525Q|ENST00000265678,p.R500Q|uc003qvc.1,p.R508Q|ENST00000510118,p.R525Q|ENST00000405189,p.R411Q|uc010kkl.1,p.R411Q|ENST00000481261,p.R411Q|ENST00000503859,p.R508Q|uc011ego.1,p.R411Q|NM_021135,p.R500Q	protein_coding, processed_transcript	uc011ego.1	nonsynonymous SNV	exon16	c.G1232A	p.R411Q	LMRGGELLDRILRQRYFSEREASDV	LMRGGELLDRILQQRYFSEREASDV	6.0	7.0	-	-	4246_6:166844023-166844023 C>T_LMRGGELLDRILQQRYFSEREASDV	0.0
11:5510223-5510223 C>T	0.0	4301	MELANOMA	-	-	-	-	OR52D1	NM_001005163,p.S96F|ENST00000322641,p.S96F|uc010qzg.2,p.S96F	protein_coding	uc010qzg.2	nonsynonymous SNV	exon1	c.C287T	p.S96F	MLAILWLHAGEISFGGCLAQMFCVH	MLAILWLHAGEIFFGGCLAQMFCVH	1.0	8.0	-	-	4301_11:5510223-5510223 C>T_MLAILWLHAGEIFFGGCLAQMFCVH	0.0
2:128046282-128046282 C>A	1.0	4046	OVARIAN	-	-	-	1	ERCC3	ENST00000285398,p.M327I|uc002tog.1,p.M263I|uc002toh.1,p.M327I|uc010flx.1,p.M82I|uc002tof.1,p.M263I|uc002toe.1,p.M82I|NM_000122,p.M327I|ENST00000493187,p.M263I	retained_intron, protein_coding, nonsense_mediated_decay	uc010flx.1	nonsynonymous SNV	exon6	c.G246T	p.M82I	VLRPYQEKSLRKMFGNGRARSGVIV	VLRPYQEKSLRKIFGNGRARSGVIV	9.0	10.0	-	-	4046_2:128046282-128046282 C>A_VLRPYQEKSLRKIFGNGRARSGVIV	0.0
1:171173059-171173059 G>A	0.0	4259	COLORECTAL	-	-	-	-	FMO2	uc001ghk.1,p.G228D|ENST00000209929,p.G228D|ENST00000441535,p.G228D	retained_intron, protein_coding, processed_transcript	uc001ghk.1	nonsynonymous SNV	exon6	c.G683A	p.G228D	HGTWVMSRISEDGYPWDSVFHTRFR	HGTWVMSRISEDDYPWDSVFHTRFR	3.0	8.0	-	-	4259_1:171173059-171173059 G>A_HGTWVMSRISEDDYPWDSVFHTRFR	0.0
9:18777034-18777034 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM158916;OCCURENCE=1(breast)	-	ADAMTSL1	uc003zne.4,p.R936H|NM_001040272,p.R936H|ENST00000380548,p.R936H	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zne.4	nonsynonymous SNV	exon19	c.G2807A	p.R936H	VTVAPFGYLKIHRLKPSDAGVYTCS	VTVAPFGYLKIHHLKPSDAGVYTCS	5.0	2.0	-	-	4284_9:18777034-18777034 G>A_VTVAPFGYLKIHHLKPSDAGVYTCS	0.0
2:160876723-160876723 G>A	0.0	4155	MELANOMA	-	-	-	-	PLA2R1	NM_001007267,p.S449F|ENST00000392771,p.S449F|uc010zcp.2,p.S449F|uc002ubf.3,p.S449F|NM_001195641,p.S449F|uc002ube.2,p.S449F|ENST00000283243,p.S449F|NM_007366,p.S449F	protein_coding, processed_transcript	uc010zcp.2	nonsynonymous SNV	exon8	c.C1346T	p.S449F	TWIGLSSNKIPVSFEWSNDSSVIFT	TWIGLSSNKIPVFFEWSNDSSVIFT	7.0	10.0	-	-	4155_2:160876723-160876723 G>A_TWIGLSSNKIPVFFEWSNDSSVIFT	0.0
18:43310353-43310353 C>T	0.0	2591	MELANOMA	-	-	-	-	SLC14A1	ENST00000588179,p.S79L|uc002lbk.4,p.S23L|ENST00000415427,p.S79L|uc002lbf.4,p.S23L|uc021ujg.1,p.S23L|ENST00000589891,p.S79L|ENST00000436407,p.S79L|NM_001146036,p.S23L|ENST00000589700,p.S23L|ENST00000586142,p.S23L|ENST00000586951,p.S23L|uc002lbj.4,p.S79L|NM_001146037,p.S79L|ENST00000586056,p.S23L|uc010dnk.3,p.S79L|NM_001128588,p.S79L|NM_015865,p.S23L|uc010xcn.2,p.S23L|ENST00000321925,p.S23L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ujg.1	nonsynonymous SNV	exon1	c.C68T	p.S23L	DSPTMVRGENQVSPCQGRRCFPKAL	DSPTMVRGENQVLPCQGRRCFPKAL	1.0	5.0	-	-	2591_18:43310353-43310353 C>T_DSPTMVRGENQVLPCQGRRCFPKAL	0.0
X:153642444-153642444 A>T	1.0	4196	COLORECTAL	-	-	-	-	TAZ	uc004fkx.3,p.E126V|ENST00000351413,p.E126V|uc004fky.3,p.E126V|uc010nuy.3,p.E144V|ENST00000299328,p.E126V|ENST00000426834,p.E144V|NM_000116,p.E126V|ENST00000475699,p.E126V|NM_181312,p.E126V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010nuy.3	nonsynonymous SNV	exon5	c.A431T	p.E144V	SLGKCVPVCRGAEFFQAENEGKGVL	SLGKCVPVCRGAVFFQAENEGKGVL	10.0	8.0	-	-	4196_X:153642444-153642444 A>T_SLGKCVPVCRGAVFFQAENEGKGVL	0.0
12:25398285-25398285 C>A	1.0	4129	NSCLC	-	-	ID=COSM1140136,COSM516;OCCURENCE=15(stomach),1(central_nervous_system),8(upper_aerodigestive_tract),2(oesophagus),3(peritoneum),1776(lung),18(thyroid),17(haematopoietic_and_lymphoid_tissue),2(testis),2(cervix),4(gastrointestinal_tract_(site_indeterminate)),13(soft_tissue),34(ovary),38(endometrium),5(skin),11(breast),8(small_intestine),1(kidney),130(pancreas),4(liver),15(urinary_tract),1(adrenal_gland),1476(large_intestine),51(biliary_tract),10(prostate)	1	KRAS	ENST00000256078,p.G12C|uc001rgp.1,p.G12C|NM_033360,p.G12C|NM_004985,p.G12C|ENST00000556131,p.G12C|ENST00000557334,p.G12C|uc001rgq.1,p.G12C|ENST00000311936,p.G12C	protein_coding	uc001rgq.1	nonsynonymous SNV	exon2	c.G34T	p.G12C	MTEYKLVVVGAGGVGKSALTIQLI	MTEYKLVVVGACGVGKSALTIQLI	7.0	8.0	-	-	4129_12:25398285-25398285 C>A_MTEYKLVVVGACGVGKSALTIQLI	0.0
1:52442644-52442644 G>-	1.0	4077	BILE DUCT	-	-	-	-	RAB3B	uc001cth.3,p.P49fs|ENST00000371655,p.P49fs|NM_002867,p.P49fs	protein_coding	uc001cth.3	frameshift deletion	exon2	c.146delC	p.P49fs	SFLFRYADDTFTPAFVSTVGIDFKV	SFLFRYADDTFTQPSLAPWASTSR	4.0	9.0	-	-	4077_1:52442644-52442644 G>-_SFLFRYADDTFTQPSLAPWASTSR	0.0
5:131289968-131289968 A>T	0.0	4046	OVARIAN	-	-	-	2	ACSL6	NM_001205248,p.F685I|uc003kvw.2,p.F331I|uc003kwa.2,p.F696I|ENST00000379264,p.F710I|ENST00000379240,p.F685I|ENST00000357096,p.F610I|ENST00000379246,p.F696I|NM_001009185,p.F710I|ENST00000544770,p.F594I|NM_001205251,p.F610I|ENST00000543479,p.F685I|uc010jdn.2,p.F700I|ENST00000379272,p.F700I|NM_001205247,p.F675I|ENST00000379244,p.F685I|uc003kvy.2,p.F710I|ENST00000379255,p.F610I|uc003kvz.2,p.F610I|uc003kwb.3,p.F675I|NM_015256,p.F710I|ENST00000296869,p.F710I|uc010jdo.2,p.F685I|uc021ydh.1,p.F610I|ENST00000431707,p.F665I|NM_001205250,p.F696I|uc003kvx.2,p.F710I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ydh.1	nonsynonymous SNV	exon20	c.T1828A	p.F610I	TLKAKRPELREYFKKQIEELYSISM	TLKAKRPELREYIKKQIEELYSISM	2.0	10.0	-	-	4046_5:131289968-131289968 A>T_TLKAKRPELREYIKKQIEELYSISM	0.0
5:112175350-112175350 ->T	0.0	4246	COLORECTAL	-	-	-	1	APC	uc010jbz.3,p.E1070fs|uc003kpy.4,p.E1353fs|ENST00000457016,p.E1353fs|ENST00000257430,p.E1353fs|uc003kpz.4,p.E1353fs|ENST00000508376,p.E1353fs|NM_001127511,p.E1335fs|NM_001127510,p.E1353fs|uc011cvt.2,p.E1335fs|NM_000038,p.E1353fs|uc010jca.3,p.E653fs	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011cvt.2	frameshift insertion	exon14	c.4006dupT	p.E1335fs	SLSSESARHKAVEFSSGAKSPSKSG	SLSSESARHKAVEFFFRSEISLQKWCSDTQKST	5.0	2.0	-	-	4246_5:112175350-112175350 ->T_SLSSESARHKAVEFFFRSEISLQKWCSDTQKST	0.0
1:240492409-240492409 A>C	0.0	3903	MELANOMA	-	-	-	-	FMN2	ENST00000319653,p.K1417Q|ENST00000441342,p.K63Q|uc010pye.2,p.K1421Q|uc010pyd.2,p.K1417Q|NM_020066,p.K1417Q|uc010pyf.1,p.K63Q	protein_coding, processed_transcript	uc010pyf.1	nonsynonymous SNV	exon4	c.A187C	p.K63Q	NRAQSDELEKIEKHGRSSKDKENAK	NRAQSDELEKIEQHGRSSKDKENAK	6.0	10.0	-	-	3903_1:240492409-240492409 A>C_NRAQSDELEKIEQHGRSSKDKENAK	0.0
13:53422174-53422174 G>A	0.0	3775	CERVICAL	-	-	-	-	PCDH8	uc001vhj.3,p.P133L|ENST00000377942,p.P133L|uc001vhi.3,p.P133L|ENST00000338862,p.P133L|NM_002590,p.P133L|NM_032949,p.P133L	protein_coding	uc001vhj.3	nonsynonymous SNV	exon1	c.C398T	p.P133L	VEVEVRDVNDHAPRFPRAQIPVEVS	VEVEVRDVNDHALRFPRAQIPVEVS	4.0	9.0	-	-	3775_13:53422174-53422174 G>A_VEVEVRDVNDHALRFPRAQIPVEVS	0.0
X:123637503-123637503 G>T	0.0	4245	COLORECTAL	-	-	-	-	TENM1	NM_014253,p.Q1118K|uc011muj.2,p.Q1117K|ENST00000422452,p.Q1118K|ENST00000371130,p.Q1118K|uc010nqy.3,p.Q1118K|NM_001163279,p.Q1117K|NM_001163278,p.Q1118K|uc004euj.3,p.Q1118K	protein_coding, processed_transcript	uc011muj.2	nonsynonymous SNV	exon19	c.C3349A	p.Q1117K	EYETCPDFILWEQRTVVLQGFEMDA	EYETCPDFILWEKRTVVLQGFEMDA	2.0	6.0	-	-	4245_X:123637503-123637503 G>T_EYETCPDFILWEKRTVVLQGFEMDA	0.0
7:116772014-116772014 A>C	1.0	4287	COLORECTAL	-	-	-	-	ST7	ENST00000323984,p.E214A|ENST00000393447,p.E171A|ENST00000393449,p.E214A|ENST00000432298,p.E168A|ENST00000265437,p.E214A|uc011knm.2,p.E171A|NM_021908,p.E214A|uc003viq.3,p.E168A|ENST00000490039,p.E162A|uc003vin.3,p.E214A	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011knm.2	nonsynonymous SNV	exon6	c.A512C	p.E171A	RISAAHEALEINEIRSRVEVPLIAS	RISAAHEALEINAIRSRVEVPLIAS	8.0	7.0	CD8	-	4287_7:116772014-116772014 A>C_RISAAHEALEINAIRSRVEVPLIAS	1.0
19:55420645-55420645 G>A	0.0	4240	BREAST	0.0009	-	-	-	NCR1	uc002qid.2,p.E38K|NM_001242356,p.E38K|NM_001145458,p.E133K|NM_004829,p.E133K|ENST00000598576,p.E121K|uc010esj.2,p.E26K|uc002qic.2,p.E133K|ENST00000338835,p.E133K|uc002qie.2,p.E133K|NM_001145457,p.E133K|ENST00000357397,p.E26K|ENST00000350790,p.E38K|uc002qif.2,p.E38K|ENST00000291890,p.E133K|uc002qib.2,p.E133K|ENST00000594765,p.E133K|ENST00000447255,p.E133K|NM_001242357,p.E38K	retained_intron, protein_coding	uc010esj.2	nonsynonymous SNV	exon2	c.G76A	p.E26K	YDTPTLSVHPGPEVISGEKVTFYCR	YDTPTLSVHPGPKVISGEKVTFYCR	1.0	5.0	-	-	4240_19:55420645-55420645 G>A_YDTPTLSVHPGPKVISGEKVTFYCR	0.0
8:25232133-25232133 C>T	1.0	3713	MELANOMA	-	-	-	-	DOCK5	uc003xek.3,p.A49V|uc003xeh.1,p.A974V|uc003xei.3,p.A830V|ENST00000276440,p.A1260V|NM_024940,p.A1260V|uc003xeg.3,p.A1260V	retained_intron, protein_coding, nonsense_mediated_decay	uc003xek.3	nonsynonymous SNV	exon3	c.C146T	p.A49V	RDLHRDCENYTEAAYTLLLHAELLQ	RDLHRDCENYTEVAYTLLLHAELLQ	7.0	4.0	-	-	3713_8:25232133-25232133 C>T_RDLHRDCENYTEVAYTLLLHAELLQ	0.0
10:99498251-99498251 G>A	1.0	4069	PANCREATIC	-	-	-	-	ZFYVE27	NM_001174122,p.R6H|NM_001174120,p.R6H|uc021pwq.1,p.R6H|uc010qpd.2,p.R6H|NM_001002261,p.R6H|ENST00000356257,p.R6H|ENST00000337540,p.R6H|NM_001002262,p.R6H|NM_144588,p.R6H|uc001kol.2,p.R6H|uc001koq.3,p.R6H|uc001kom.2,p.R6H|ENST00000453958,p.R6H|NM_001174119,p.R6H|ENST00000370613,p.R6H|ENST00000359980,p.R6H|ENST00000357540,p.R6H|uc010qpa.2,p.R6H|ENST00000393677,p.R6H	protein_coding, processed_transcript, nonsense_mediated_decay	uc021pwq.1	nonsynonymous SNV	exon1	c.G17A	p.R6H	MQTSEREGSGPELSPSVM	MQTSEHEGSGPELSPSVM	9.0	9.0	CD8	-	4069_10:99498251-99498251 G>A_MQTSEHEGSGPELSPSVM	2.0
14:20010235-20010235 A>G	0.0	4326	BREAST	-	rs8135863	-	-	POTEM	ENST00000551509,p.V308A|ENST00000547848,p.V308A|NM_001145442,p.V308A|uc001vwc.3,p.V308A	protein_coding, nonsense_mediated_decay	uc001vwc.3	nonsynonymous SNV	exon5	c.T923C	p.V308A	ANLNALDRYGRTVLILAVCCGSASI	ANLNALDRYGRTALILAVCCGSASI	4.0	7.0	-	-	4326_14:20010235-20010235 A>G_ANLNALDRYGRTALILAVCCGSASI	0.0
1:6556602-6556602 C>T	1.0	4326	BREAST	-	-	-	-	PLEKHG5	ENST00000377740,p.G32E|NM_198681,p.G32E|ENST00000377748,p.G32E|uc001anq.2,p.G32E|uc001anp.2,p.G32E	retained_intron, protein_coding	uc001anq.2	nonsynonymous SNV	exon2	c.G95A	p.G32E	SGTDDQSPAEKKGLRCQNPACMDKG	SGTDDQSPAEKKELRCQNPACMDKG	6.0	8.0	-	-	4326_1:6556602-6556602 C>T_SGTDDQSPAEKKELRCQNPACMDKG	0.0
19:49573484-49573484 G>A	1.0	4196	COLORECTAL	-	-	-	-	KCNA7	uc002pmg.3,p.R403W|ENST00000221444,p.R403W|NM_031886,p.R403W	protein_coding	uc002pmg.3	nonsynonymous SNV	exon2	c.C1207T	p.R403W	PVIVSNFSYFYHRETEGEEAGMFSH	PVIVSNFSYFYHWETEGEEAGMFSH	2.0	8.0	-	-	4196_19:49573484-49573484 G>A_PVIVSNFSYFYHWETEGEEAGMFSH	0.0
1:109193763-109193763 G>A	1.0	3879	MELANOMA	-	-	-	-	HENMT1	uc009wer.3,p.S156F|ENST00000370032,p.S156F|NM_144584,p.S156F|uc001dvu.4,p.S156F|uc001dvt.4,p.S156F|ENST00000370031,p.S156F|ENST00000402983,p.S156F|ENST00000420055,p.S156F|NM_001102592,p.S156F	protein_coding, processed_transcript	uc009wer.3	nonsynonymous SNV	exon6	c.C467T	p.S156F	RFPEVVFGYLSPSMIVISTPNSEFN	RFPEVVFGYLSPFMIVISTPNSEFN	5.0	4.0	-	-	3879_1:109193763-109193763 G>A_RFPEVVFGYLSPFMIVISTPNSEFN	0.0
19:11623896-11623896 A>C	1.0	4287	COLORECTAL	-	-	-	-	ECSIT	ENST00000592571,p.L30V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	ENST00000592571	nonsynonymous SNV	exon1	c.T88G	p.L30V	LAMFGLRHMEPDLSARVTIYQAPCA	LAMFGLRHMEPDVSARVTIYQAPCA	9.0	6.0	-	-	4287_19:11623896-11623896 A>C_LAMFGLRHMEPDVSARVTIYQAPCA	0.0
10:83637750-83637750 G>A	0.0	4284	COLORECTAL	-	-	ID=COSM1474824;OCCURENCE=1(breast)	-	NRG3	ENST00000404576,p.V12I|ENST00000555784,p.V12I|uc021pvi.1,p.V12I|uc021pvg.1,p.V12I|uc021pve.1,p.V12I|ENST00000556918,p.V12I	protein_coding, nonsense_mediated_decay	uc021pvi.1	nonsynonymous SNV	exon1	c.G34A	p.V12I	MECGIPPTLVCVGRGGGLHTVGVF	MECGIPPTLVCIGRGGGLHTVGVF	3.0	1.0	-	-	4284_10:83637750-83637750 G>A_MECGIPPTLVCIGRGGGLHTVGVF	0.0
4:1305927-1305927 A>C	1.0	4345	COLORECTAL	-	-	-	-	MAEA	ENST00000502558,p.K77T|ENST00000452175,p.K66T|NM_001297430,p.K77T|uc011bvb.2,p.K77T	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc011bvb.2	nonsynonymous SNV	exon2	c.A230C	p.K77T	DSVVSLLDGVVEKLSVLKRKDLVNI	DSVVSLLDGVVETLSVLKRKDLVNI	10.0	2.0	-	-	4345_4:1305927-1305927 A>C_DSVVSLLDGVVETLSVLKRKDLVNI	0.0
17:27893596-27893596 G>A	0.0	3795	MELANOMA	-	-	-	-	ABHD15	uc002hed.2,p.A130V|NM_198147,p.A130V|ENST00000307201,p.A130V	protein_coding	uc002hed.2	nonsynonymous SNV	exon1	c.C389T	p.A130V	PGPELAREYLQLADDGLVALDWVVG	PGPELAREYLQLVDDGLVALDWVVG	4.0	1.0	-	-	3795_17:27893596-27893596 G>A_PGPELAREYLQLVDDGLVALDWVVG	0.0
3:147113979-147113979 G>C	0.0	4259	COLORECTAL	-	-	-	-	ZIC4	ENST00000525172,p.F166L|ENST00000425731,p.F154L|ENST00000484399,p.F116L|uc011bno.2,p.F166L|ENST00000383075,p.F116L|uc003ewc.2,p.F46L|ENST00000473123,p.F116L|NM_001168378,p.F166L|uc003ewd.2,p.F116L|ENST00000462748,p.F116L|NM_032153,p.F116L|NM_001168379,p.F154L|uc021xff.1,p.F154L	retained_intron, protein_coding, processed_transcript	uc021xff.1	nonsynonymous SNV	exon3	c.C462G	p.F154L	TVNLAAPHGPGAFFRYMRQPIKQEL	TVNLAAPHGPGALFRYMRQPIKQEL	5.0	9.0	-	-	4259_3:147113979-147113979 G>C_TVNLAAPHGPGALFRYMRQPIKQEL	0.0
13:36379865-36379865 C>T	1.0	4126	NSCLC	-	-	-	-	DCLK1	NM_001195415,p.V332I|NM_004734,p.V639I|uc001uve.4,p.V332I|NM_001195416,p.V332I|ENST00000379893,p.V332I|uc010abk.3,p.V159I|ENST00000255448,p.V639I|uc001uvf.3,p.V639I|ENST00000360631,p.V639I|uc010teh.2,p.V332I	protein_coding, processed_transcript	uc010teh.2	nonsynonymous SNV	exon11	c.G994A	p.V332I	MLLVDVDQRFSAVQVLEHPWVNDDG	MLLVDVDQRFSAIQVLEHPWVNDDG	3.0	4.0	-	-	4126_13:36379865-36379865 C>T_MLLVDVDQRFSAIQVLEHPWVNDDG	0.0
3:47446239-47446239 C>T	0.0	4081	COLORECTAL	0.0014	-	-	-	PTPN23	uc011baw.1,p.S61L|ENST00000456221,p.S61L|uc003crf.1,p.S86L|ENST00000265562,p.S86L|NM_015466,p.S86L	retained_intron, protein_coding, nonsense_mediated_decay	uc011baw.1	nonsynonymous SNV	exon2	c.C182T	p.S61L	QLHYLQSRVPMGSGQEAAVPVTWTE	QLHYLQSRVPMGLGQEAAVPVTWTE	8.0	9.0	-	-	4081_3:47446239-47446239 C>T_QLHYLQSRVPMGLGQEAAVPVTWTE	0.0
15:48539631-48539631 T>C	0.0	4158	COLORECTAL	-	-	ID=COSM1265667,COSM1265666;OCCURENCE=1(oesophagus)	-	SLC12A1	uc010bem.3,p.L553P|uc001zwq.4,p.L324P|ENST00000558405,p.L553P|uc001zwr.4,p.L280P|ENST00000396577,p.L553P|uc001zwn.4,p.L553P|uc010uew.1,p.L359P|NM_001184832,p.L553P|NM_000338,p.L553P|ENST00000380993,p.L553P|ENST00000559641,p.L366P	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010uew.1	nonsynonymous SNV	exon12	c.T1076C	p.L359P	NNEPLRGYILTFLIAMAFILIAELN	NNEPLRGYILTFPIAMAFILIAELN	7.0	1.0	-	-	4158_15:48539631-48539631 T>C_NNEPLRGYILTFPIAMAFILIAELN	0.0
12:41582655-41582655 G>T	0.0	4281	COLORECTAL	-	-	-	-	PDZRN4	NM_001164595,p.C133F|uc010skn.2,p.C133F|ENST00000402685,p.C133F	retained_intron, protein_coding	uc010skn.2	nonsynonymous SNV	exon1	c.G398T	p.C133F	GLGGGEVPARGGCGPTPRAGRGGGA	GLGGGEVPARGGFGPTPRAGRGGGA	2.0	5.0	-	-	4281_12:41582655-41582655 G>T_GLGGGEVPARGGFGPTPRAGRGGGA	0.0
6:51918854-51918854 G>A	1.0	4329	COLORECTAL	-	-	-	-	PKHD1	uc003pah.1,p.T649M|ENST00000371117,p.T649M|ENST00000340994,p.T649M|NM_170724,p.T649M|uc003pai.3,p.T649M|NM_138694,p.T649M	protein_coding	uc003pai.3	nonsynonymous SNV	exon20	c.C1946T	p.T649M	NMVKNTTCDWSLTRTSPESWQFDCT	NMVKNTTCDWSLMRTSPESWQFDCT	4.0	6.0	-	-	4329_6:51918854-51918854 G>A_NMVKNTTCDWSLMRTSPESWQFDCT	0.0
2:178481702-178481702 T>G	0.0	4346	COLORECTAL	-	-	-	-	TTC30A	ENST00000355689,p.K576N|NM_152275,p.K576N|uc002ulo.3,p.K576N	protein_coding	uc002ulo.3	nonsynonymous SNV	exon1	c.A1728C	p.K576N	ISRVIKSLEPYNKKLGTDTWYYAKR	ISRVIKSLEPYNNKLGTDTWYYAKR	4.0	4.0	-	-	4346_2:178481702-178481702 T>G_ISRVIKSLEPYNNKLGTDTWYYAKR	0.0
11:61624977-61624977 C>T	1.0	4000	MELANOMA	-	-	-	-	FADS2	NM_004265,p.T286I|ENST00000522056,p.T255I|uc001nsk.3,p.T286I|uc001nsl.1,p.T286I|NM_001281501,p.T264I|ENST00000355484,p.T52I|ENST00000278840,p.T286I|NM_001281502,p.T255I|ENST00000521571,p.T52I|ENST00000257261,p.T264I|uc001nsj.2,p.T264I|ENST00000521849,p.T286I|uc010rlo.1,p.T255I	retained_intron, protein_coding	uc010rlo.1	nonsynonymous SNV	exon7	c.C764T	p.T255I	LIPMYFQYQIIMTMIVHKNWVDLAW	LIPMYFQYQIIMIMIVHKNWVDLAW	7.0	2.0	-	-	4000_11:61624977-61624977 C>T_LIPMYFQYQIIMIMIVHKNWVDLAW	0.0
7:138268707-138268707 T>C	1.0	3678	MELANOMA	-	-	-	1	TRIM24	uc003vuc.3,p.F969S|NM_015905,p.F969S|uc003vub.3,p.F935S|ENST00000343526,p.F969S|NM_003852,p.F935S|ENST00000415680,p.F935S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003vuc.3	nonsynonymous SNV	exon18	c.T2906C	p.F969S	SMYSKPEDFVADFRLIFQNCAEFNE	SMYSKPEDFVADSRLIFQNCAEFNE	9.0	1.0	-	-	3678_7:138268707-138268707 T>C_SMYSKPEDFVADSRLIFQNCAEFNE	0.0
1:17668464-17668464 G>A	0.0	4196	COLORECTAL	-	-	-	-	PADI4	uc001baj.2,p.V227I|uc009vpc.2,p.V227I|NM_012387,p.V227I|ENST00000375448,p.V227I	protein_coding, processed_transcript	uc009vpc.2	nonsynonymous SNV	exon7	c.G679A	p.V227I	QATRGKLSSKCSVVLGPKWPSHYLM	QATRGKLSSKCSIVLGPKWPSHYLM	5.0	6.0	-	-	4196_1:17668464-17668464 G>A_QATRGKLSSKCSIVLGPKWPSHYLM	0.0
15:78783042-78783042 A>G	1.0	4037	NSCLC	-	-	ID=COSM254747;OCCURENCE=3(urinary_tract)	-	IREB2	uc010unb.1,p.I505V|NM_004136,p.I755V|uc002bdr.2,p.I755V|ENST00000258886,p.I755V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010unb.1	nonsynonymous SNV	exon17	c.A1513G	p.I505V	LLYLGDSVTTDHISPAGSIARNSAA	LLYLGDSVTTDHVSPAGSIARNSAA	7.0	10.0	-	-	4037_15:78783042-78783042 A>G_LLYLGDSVTTDHVSPAGSIARNSAA	0.0
22:30639731-30639731 G>A	0.0	4186	BREAST	-	-	ID=COSM1033239;OCCURENCE=1(endometrium)	-	LIF	ENST00000249075,p.S173L|uc003agz.3,p.S173L|NM_002309,p.S173L	protein_coding	uc003agz.3	nonsynonymous SNV	exon3	c.C518T	p.S173L	VGHVDVTYGPDTSGKDVFQKKKLGC	VGHVDVTYGPDTLGKDVFQKKKLGC	1.0	8.0	-	-	4186_22:30639731-30639731 G>A_VGHVDVTYGPDTLGKDVFQKKKLGC	0.0
9:6460703-6460703 C>G	0.0	4238	COLORECTAL	-	-	-	-	UHRF2	uc003zjy.3,p.Q259E|ENST00000276893,p.Q259E|NM_152896,p.Q259E|ENST00000450508,p.Q36E|uc003zka.1,p.Q36E|ENST00000468435,p.Q259E	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003zka.1	nonsynonymous SNV	exon2	c.C106G	p.Q36E	VVMVNYNVESPGQRGFWFDAEITTL	VVMVNYNVESPGERGFWFDAEITTL	6.0	2.0	-	-	4238_9:6460703-6460703 C>G_VVMVNYNVESPGERGFWFDAEITTL	0.0
8:110476992-110476992 C>T	0.0	4346	COLORECTAL	-	-	-	-	PKHD1L1	ENST00000378402,p.A2644V|uc003yne.3,p.A2644V|NM_177531,p.A2644V	retained_intron, protein_coding	uc003yne.3	nonsynonymous SNV	exon49	c.C7931T	p.A2644V	PMQTGSCTSTVPAPAIFNSLTTWNC	PMQTGSCTSTVPVPAIFNSLTTWNC	4.0	1.0	-	-	4346_8:110476992-110476992 C>T_PMQTGSCTSTVPVPAIFNSLTTWNC	0.0
8:99961325-99961325 A>T	0.0	3919	MELANOMA	-	-	-	-	OSR2	NM_053001,p.M49L|ENST00000435298,p.M49L|ENST00000297565,p.M49L|ENST00000522510,p.M49L|ENST00000520951,p.M102L|ENST00000518199,p.M49L|ENST00000457907,p.M170L|ENST00000523368,p.M49L|NM_001286841,p.M170L|uc003yir.3,p.M49L|uc011lgx.2,p.M170L|NM_001142462,p.M49L|uc010mbn.2,p.M49L|uc003yiq.3,p.M49L	protein_coding, processed_transcript	uc011lgx.2	nonsynonymous SNV	exon3	c.A508T	p.M170L	LQGLYGLSAVQTMHMNHWTLGYPNV	LQGLYGLSAVQTLHMNHWTLGYPNV	2.0	3.0	-	-	3919_8:99961325-99961325 A>T_LQGLYGLSAVQTLHMNHWTLGYPNV	0.0
17:33749122-33749122 C>A	0.0	4126	NSCLC	-	-	-	-	SLFN12	NM_018042,p.R309L|ENST00000304905,p.R309L|ENST00000452764,p.R309L|uc002hji.4,p.R309L|uc002hjj.4,p.R309L|ENST00000394562,p.R309L|uc010cts.3,p.R309L|NM_001289009,p.R309L	retained_intron, protein_coding, processed_transcript	uc010cts.3	nonsynonymous SNV	exon2	c.G926T	p.R309L	SLCGYVCALRVERFCCAVFAKEPDS	SLCGYVCALRVELFCCAVFAKEPDS	2.0	6.0	-	-	4126_17:33749122-33749122 C>A_SLCGYVCALRVELFCCAVFAKEPDS	0.0
11:61067637-61067637 C>T	1.0	2369	MELANOMA	-	-	-	-	DDB1	ENST00000538470,p.V179I|ENST00000451943,p.V119I|ENST00000301764,p.V1132I|uc001nrc.5,p.V1132I|ENST00000450997,p.V443I|NM_001923,p.V1132I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001nrc.5	nonsynonymous SNV	exon27	c.G3394A	p.V1132I	MKREATADDLIKVVEELTRIH	MKREATADDLIKIVEELTRIH	10.0	7.0	-	-	2369_11:61067637-61067637 C>T_MKREATADDLIKIVEELTRIH	0.0
9:37888304-37888304 G>T	1.0	4287	COLORECTAL	-	-	-	-	SLC25A51	uc022bgx.1,p.R82S|ENST00000380590,p.R82S|uc004aav.2,p.R82S|NM_033412,p.R82S|ENST00000242275,p.R82S|ENST00000377716,p.R82S	protein_coding, processed_transcript	uc022bgx.1	nonsynonymous SNV	exon1	c.C244A	p.R82S	LQLRRDGFRNLYRGILPPLMQKTTT	LQLRRDGFRNLYSGILPPLMQKTTT	6.0	10.0	-	-	4287_9:37888304-37888304 G>T_LQLRRDGFRNLYSGILPPLMQKTTT	0.0
11:92533986-92533986 G>C	0.0	4284	COLORECTAL	-	-	-	2	FAT3	uc001pdj.4,p.V2603L|NM_001008781,p.V2603L|ENST00000409404,p.V2603L|ENST00000298047,p.V2603L|ENST00000525166,p.V2453L	retained_intron, protein_coding, processed_transcript	uc001pdj.4	nonsynonymous SNV	exon9	c.G7807C	p.V2603L	VDENDNAPQFMTVEYRASVRADVGR	VDENDNAPQFMTLEYRASVRADVGR	4.0	8.0	-	-	4284_11:92533986-92533986 G>C_VDENDNAPQFMTLEYRASVRADVGR	0.0
14:45693418-45693418 G>A	1.0	3716	MELANOMA	-	-	-	-	MIS18BP1	ENST00000310806,p.T791I|NM_018353,p.T791I|uc001wwf.3,p.T791I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc001wwf.3	nonsynonymous SNV	exon11	c.C2372T	p.T791I	EKEIKRKAEVKKTKAGNTKEAVVHL	EKEIKRKAEVKKIKAGNTKEAVVHL	8.0	9.0	-	-	3716_14:45693418-45693418 G>A_EKEIKRKAEVKKIKAGNTKEAVVHL	0.0
1:65146969-65146969 G>C	0.0	4240	BREAST	-	-	-	-	CACHD1	uc001dbq.1,p.E849D|uc001dbp.1,p.E849D|uc010opa.1,p.E338D|uc001dbo.1,p.E1094D|ENST00000371073,p.E1145D|NM_020925,p.E1094D|ENST00000290039,p.E1094D|NM_001293274,p.E849D	retained_intron, protein_coding, processed_transcript	uc010opa.1	nonsynonymous SNV	exon11	c.G1014C	p.E338D	AAQEMSVRMSNLENDRDERDDDSHE	AAQEMSVRMSNLDNDRDERDDDSHE	4.0	9.0	-	-	4240_1:65146969-65146969 G>C_AAQEMSVRMSNLDNDRDERDDDSHE	0.0
13:98662384-98662384 A>G	1.0	4180	BREAST	-	-	-	-	IPO5	uc001vng.1,p.D275G|ENST00000261574,p.D672G|ENST00000539640,p.D529G|uc010tik.1,p.D529G|uc010til.1,p.D594G|ENST00000490680,p.D654G|uc001vnf.1,p.D654G|NM_002271,p.D672G|uc001vne.3,p.D672G|ENST00000357602,p.D654G	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010til.1	nonsynonymous SNV	exon17	c.A1781G	p.D594G	LLDTQDMENMSDDDGWEFVNLGDQQ	LLDTQDMENMSDGDGWEFVNLGDQQ	10.0	8.0	-	-	4180_13:98662384-98662384 A>G_LLDTQDMENMSDGDGWEFVNLGDQQ	0.0
15:39880416-39880416 C>T	1.0	3713	MELANOMA	-	-	-	-	THBS1	ENST00000260356,p.P490S|uc001zkh.3,p.P490S|NM_003246,p.P490S	retained_intron, protein_coding	uc001zkh.3	nonsynonymous SNV	exon9	c.C1468T	p.P490S	ARETKACKKDACPINGGWGPWSPWD	ARETKACKKDACSINGGWGPWSPWD	10.0	9.0	-	-	3713_15:39880416-39880416 C>T_ARETKACKKDACSINGGWGPWSPWD	0.0
2:183846001-183846001 C>A	0.0	4238	COLORECTAL	-	-	-	-	NCKAP1	NM_205842,p.D444Y|ENST00000361354,p.D438Y|NM_013436,p.D438Y|ENST00000360982,p.D444Y|uc002upc.4,p.D438Y|uc002upb.4,p.D444Y	retained_intron, protein_coding, processed_transcript	uc002upc.4	nonsynonymous SNV	exon13	c.G1312T	p.D438Y	MQRYYVQYLSGFDAVVLNELVQNLS	MQRYYVQYLSGFYAVVLNELVQNLS	8.0	6.0	CD8	-	4238_2:183846001-183846001 C>A_MQRYYVQYLSGFYAVVLNELVQNLS	1.0
8:41551469-41551469 C>T	0.0	4287	COLORECTAL	-	-	-	2	ANK1	uc003xoh.3,p.R476K|NM_020475,p.R1160K|ENST00000396942,p.R1160K|NM_020476,p.R1160K|NM_001142446,p.R1201K|ENST00000265709,p.R1201K|NM_000037,p.R1160K|uc003xol.3,p.R1160K|ENST00000352337,p.R1160K|uc003xoj.3,p.R1160K|ENST00000347528,p.R1160K|uc003xoi.3,p.R1160K|uc003xok.3,p.R1160K|ENST00000289734,p.R1160K|ENST00000379758,p.R1160K|ENST00000396945,p.R1160K|NM_020477,p.R1160K|uc003xom.3,p.R1201K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003xom.3	nonsynonymous SNV	exon30	c.G3602A	p.R1201K	RIPLPPSWTDNPRDSGEGDTTSLRL	RIPLPPSWTDNPKDSGEGDTTSLRL	3.0	8.0	-	-	4287_8:41551469-41551469 C>T_RIPLPPSWTDNPKDSGEGDTTSLRL	0.0
20:45905204-45905204 G>A	1.0	3466	MELANOMA	-	-	-	-	ZMYND8	ENST00000360911,p.S420F|NM_001281779,p.S177F|uc010zxz.1,p.S420F|NM_012408,p.S445F|NM_001281778,p.S420F|ENST00000458360,p.S420F|ENST00000446994,p.S362F|NM_183047,p.S445F|uc002xtc.1,p.S445F|NM_183048,p.S420F|NM_001281771,p.S420F|ENST00000262975,p.S425F|uc002xtd.1,p.S420F|uc010zya.1,p.S425F|uc002xsz.1,p.S362F|uc002xsx.1,p.S177F|uc002xta.1,p.S425F|NM_001281780,p.S177F|NM_001281781,p.S420F|NM_001281782,p.S420F|uc010ghr.1,p.S400F|NM_001281775,p.S445F|uc002xss.2,p.S425F|uc010zxy.1,p.S452F|uc002xst.1,p.S400F|uc002xte.1,p.S425F|NM_001281773,p.S425F|uc002xsv.1,p.S400F|uc002xtg.3,p.S419F|NM_001281783,p.S445F|NM_001281776,p.S445F|uc002xsw.1,p.S177F|uc002xtb.1,p.S445F|NM_001281774,p.S425F|NM_001281772,p.S425F|ENST00000355972,p.S425F|ENST00000540497,p.S420F|ENST00000536340,p.S452F|ENST00000352431,p.S445F|ENST00000471951,p.S445F|uc002xtf.1,p.S445F|ENST00000311275,p.S425F|uc002xsu.1,p.S425F|NM_001281777,p.S420F|NM_001281784,p.S420F|ENST00000372023,p.S420F|ENST00000396281,p.S425F|ENST00000461685,p.S445F|uc002xsy.1,p.S400F|uc010ghq.1,p.S102F|uc010ghs.2,p.S419F	protein_coding, processed_transcript	uc010zya.1	nonsynonymous SNV	exon12	c.C1274T	p.S425F	KPVLSGGTGRRISLSDMPRSPMSTN	KPVLSGGTGRRIFLSDMPRSPMSTN	10.0	3.0	-	-	3466_20:45905204-45905204 G>A_KPVLSGGTGRRIFLSDMPRSPMSTN	0.0
2:98834427-98834427 C>T	0.0	4252	COLORECTAL	-	-	-	-	VWA3B	uc010yvi.1,p.T309I|uc002syo.3,p.T652I|uc002sym.3,p.T652I|uc002syp.1,p.T44I|ENST00000477737,p.T652I|NM_144992,p.T652I	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010yvi.1	nonsynonymous SNV	exon8	c.C926T	p.T309I	IANRFLKEVAALTGGEFHFYNFGCK	IANRFLKEVAALIGGEFHFYNFGCK	5.0	8.0	-	-	4252_2:98834427-98834427 C>T_IANRFLKEVAALIGGEFHFYNFGCK	0.0
14:64701791-64701791 C>A	1.0	4110	BILE DUCT	-	-	-	-	ESR2	NM_001271877,p.D344Y|NM_001040275,p.D435Y|ENST00000358599,p.D435Y|ENST00000357782,p.D435Y|ENST00000267525,p.D344Y|NM_001437,p.D435Y|ENST00000353772,p.D435Y|NM_001214902,p.D435Y|uc001xgv.3,p.D435Y|uc010aqc.1,p.D344Y|ENST00000542956,p.D435Y|NM_001271876,p.D435Y|uc001xgz.2,p.D435Y|ENST00000554572,p.D435Y|uc001xgy.2,p.D435Y|uc001xgu.3,p.D435Y|ENST00000341099,p.D435Y|uc001xha.1,p.D435Y|ENST00000556275,p.D435Y|ENST00000555278,p.D435Y|uc031qoy.1,p.D435Y|NM_001291723,p.D435Y|NM_001291712,p.D435Y|uc001xgx.3,p.D435Y|ENST00000557772,p.D435Y|ENST00000553796,p.D435Y	protein_coding, processed_transcript, nonsense_mediated_decay	uc031qoy.1	nonsynonymous SNV	exon7	c.G1303T	p.D435Y	SRKLAHLLNAVTDALVWVIAKSGIS	SRKLAHLLNAVTYALVWVIAKSGIS	2.0	9.0	-	-	4110_14:64701791-64701791 C>A_SRKLAHLLNAVTYALVWVIAKSGIS	0.0
13:108863522-108863522 C>T	1.0	4287	COLORECTAL	-	-	-	-	LIG4	ENST00000442234,p.R32H|NM_206937,p.R32H|ENST00000405925,p.R32H|uc001vqn.3,p.R32H|uc021rmk.1,p.R32H|NM_001098268,p.R32H|NM_002312,p.R32H|uc010agf.3,p.R32H|ENST00000356922,p.R32H|uc001vqp.3,p.R32H|uc001vqo.3,p.R32H	protein_coding	uc021rmk.1	nonsynonymous SNV	exon1	c.G95A	p.R32H	CSTLERIQKSKGRAEKIRHFREFLD	CSTLERIQKSKGHAEKIRHFREFLD	7.0	6.0	-	-	4287_13:108863522-108863522 C>T_CSTLERIQKSKGHAEKIRHFREFLD	0.0
18:44426698-44426698 G>A	1.0	3713	MELANOMA	-	-	ID=COSM1711306,COSM1711305;OCCURENCE=1(skin)	-	PIAS2	uc002lck.3,p.S278F|ENST00000585916,p.S278F|ENST00000324794,p.S278F|uc002lcm.3,p.S278F|uc002lcn.1,p.S282F|NM_004671,p.S278F|uc002lcl.3,p.S278F|NM_173206,p.S278F	protein_coding, processed_transcript, nonsense_mediated_decay	uc002lcn.1	nonsynonymous SNV	exon6	c.C845T	p.S282F	LVRLSSAVPNQISISWASEIGKNYS	LVRLSSAVPNQIFISWASEIGKNYS	7.0	2.0	-	-	3713_18:44426698-44426698 G>A_LVRLSSAVPNQIFISWASEIGKNYS	0.0
20:4228802-4228802 G>A	0.0	4275	COLORECTAL	-	-	-	-	ADRA1D	ENST00000379453,p.A268V|NM_000678,p.A268V|uc002wkr.2,p.A268V	protein_coding	uc002wkr.2	nonsynonymous SNV	exon1	c.C803T	p.A268V	VFSSVCSFYLPMAVIVVMYCRVYVV	VFSSVCSFYLPMVVIVVMYCRVYVV	1.0	8.0	-	-	4275_20:4228802-4228802 G>A_VFSSVCSFYLPMVVIVVMYCRVYVV	0.0
X:34150304-34150304 G>A	0.0	4281	COLORECTAL	-	-	ID=COSM1472226;OCCURENCE=1(prostate)	-	FAM47A	NM_203408,p.A31V|uc004ddg.3,p.A31V|ENST00000346193,p.A31V	protein_coding	uc004ddg.3	nonsynonymous SNV	exon1	c.C92T	p.A31V	PWYCNKRPSKCFAKCKHRRLRFPPM	PWYCNKRPSKCFVKCKHRRLRFPPM	1.0	1.0	-	-	4281_X:34150304-34150304 G>A_PWYCNKRPSKCFVKCKHRRLRFPPM	0.0
15:74467621-74467621 C>T	1.0	4326	BREAST	-	-	-	-	ISLR	ENST00000249842,p.A141V|uc002axg.1,p.A141V|ENST00000395118,p.A141V|NM_201526,p.A141V|NM_005545,p.A141V|ENST00000560862,p.A141V|uc021sqf.1,p.A141V|uc002axh.1,p.A141V	protein_coding	uc021sqf.1	nonsynonymous SNV	exon1	c.C422T	p.A141V	MDSNELTFIPRDAFRSLRALRSLQL	MDSNELTFIPRDVFRSLRALRSLQL	9.0	9.0	CD8	-	4326_15:74467621-74467621 C>T_MDSNELTFIPRDVFRSLRALRSLQL	1.0
14:80328041-80328041 G>T	0.0	4126	NSCLC	-	-	-	-	NRXN3	ENST00000428277,p.G372W|NM_001272020,p.G550W|uc001xur.5,p.G345W|NM_001105250,p.G372W|ENST00000557594,p.G550W|uc001xuq.3,p.G550W|uc010asw.4,p.G372W|uc001xun.4,p.G974W|ENST00000554719,p.G974W|ENST00000281127,p.G345W|ENST00000335750,p.G974W|NM_138970,p.G345W|NM_004796,p.G974W	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010asw.4	nonsynonymous SNV	exon7	c.G1114T	p.G372W	ANPTEPGIRRVPGASEVIRESSSTT	ANPTEPGIRRVPWASEVIRESSSTT	2.0	9.0	-	-	4126_14:80328041-80328041 G>T_ANPTEPGIRRVPWASEVIRESSSTT	0.0
7:154002604-154002604 G>A	0.0	4245	COLORECTAL	-	-	-	-	DPP6	ENST00000427557,p.A9T|NM_001290252,p.A9T|uc011kvq.2,p.A9T|NM_001936,p.A9T|ENST00000332007,p.A9T|uc010lqh.1,p.A9T|uc003wlm.3,p.A9T	retained_intron, protein_coding, processed_transcript	uc011kvq.2	nonsynonymous SNV	exon1	c.G25A	p.A9T	MTTAKEPSASGKSVQQQEQEL	MTTAKEPSTSGKSVQQQEQEL	3.0	7.0	-	-	4245_7:154002604-154002604 G>A_MTTAKEPSTSGKSVQQQEQEL	0.0
19:2834278-2834278 G>A	1.0	4000	MELANOMA	-	-	-	-	ZNF554	uc002lwl.2,p.E298K|NM_001102651,p.E349K|uc002lwm.2,p.E349K|ENST00000317243,p.E349K	retained_intron, protein_coding, nonsense_mediated_decay	uc002lwm.2	nonsynonymous SNV	exon5	c.G1045A	p.E349K	HSLSEHQRIHTGEKPYECQECGRAF	HSLSEHQRIHTGKKPYECQECGRAF	5.0	4.0	-	-	4000_19:2834278-2834278 G>A_HSLSEHQRIHTGKKPYECQECGRAF	0.0
9:35389882-35389882 C>T	1.0	4326	BREAST	-	-	-	-	UNC13B	NM_006377,p.R963W|ENST00000378496,p.R963W|ENST00000396787,p.R975W|uc003zwq.3,p.R963W|ENST00000378495,p.R963W|uc003zwr.3,p.R963W	protein_coding, processed_transcript	uc003zwr.3	nonsynonymous SNV	exon24	c.C2887T	p.R963W	QELPPEEQGPSIRNLDFWPKLITLI	QELPPEEQGPSIWNLDFWPKLITLI	8.0	10.0	-	-	4326_9:35389882-35389882 C>T_QELPPEEQGPSIWNLDFWPKLITLI	0.0
2:31133871-31133871 C>T	0.0	2556	MELANOMA	-	-	ID=COSM1690384;OCCURENCE=1(skin)	-	GALNT14	uc002rnq.3,p.D499N|NM_024572,p.D519N|NM_001253827,p.D499N|uc010ymr.2,p.D484N|uc002rns.3,p.D524N|ENST00000349752,p.D519N|ENST00000420311,p.D484N|ENST00000356174,p.D486N|ENST00000324589,p.D524N|NM_001253826,p.D524N|uc002rnr.3,p.D519N|ENST00000406653,p.D499N	protein_coding, processed_transcript, nonsense_mediated_decay	uc010ymr.2	nonsynonymous SNV	exon16	c.G1450A	p.D484N	SHIEHIASHLCLDTDMFGDGTENGK	SHIEHIASHLCLNTDMFGDGTENGK	2.0	6.0	-	-	2556_2:31133871-31133871 C>T_SHIEHIASHLCLNTDMFGDGTENGK	0.0
12:21593382-21593382 G>T	0.0	4284	COLORECTAL	-	-	-	-	PYROXD1	uc001rew.3,p.Q55H|ENST00000545178,p.Q55H|NM_024854,p.Q55H|ENST00000240651,p.Q55H|ENST00000544970,p.Q55H|ENST00000543476,p.Q55H	retained_intron, protein_coding, nonsense_mediated_decay	uc001rew.3	nonsynonymous SNV	exon2	c.G165T	p.Q55H	ASPVIKAVTNFKQISKILEEFDVEE	ASPVIKAVTNFKHISKILEEFDVEE	7.0	6.0	-	-	4284_12:21593382-21593382 G>T_ASPVIKAVTNFKHISKILEEFDVEE	0.0
18:77806030-77806030 G>A	1.0	3678	MELANOMA	-	-	-	-	RBFA	ENST00000306735,p.D303N|NM_024805,p.D303N|uc002lns.3,p.D303N	retained_intron, protein_coding, processed_transcript	uc002lns.3	nonsynonymous SNV	exon7	c.G907A	p.D303N	SLKSYLSGEEVEDDLDLVGAPEYEC	SLKSYLSGEEVENDLDLVGAPEYEC	8.0	4.0	-	-	3678_18:77806030-77806030 G>A_SLKSYLSGEEVENDLDLVGAPEYEC	0.0
1:248512866-248512866 C>T	0.0	2359	MELANOMA	-	-	-	-	OR14C36	ENST00000317861,p.P264S|NM_001001918,p.P264S|uc010pzl.2,p.P264S	protein_coding	uc010pzl.2	nonsynonymous SNV	exon1	c.C790T	p.P264S	SCSSVYLRPPAIPAATQDLILSGFY	SCSSVYLRPPAISAATQDLILSGFY	1.0	2.0	-	-	2359_1:248512866-248512866 C>T_SCSSVYLRPPAISAATQDLILSGFY	0.0
6:56470483-56470483 T>A	1.0	3713	MELANOMA	-	-	-	-	RNU6-71P	uc021zax.1,p.E2444D|ENST00000370754,p.E2948D|ENST00000361203,p.E2770D|ENST00000439203,p.E2444D|ENST00000446842,p.E2444D|ENST00000312431,p.E2770D|ENST00000370769,p.E2770D	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021zax.1	nonsynonymous SNV	exon26	c.A7332T	p.E2444D	LPELTDSVKGKDEYFKNMTPKVDSS	LPELTDSVKGKDDYFKNMTPKVDSS	10.0	9.0	-	-	3713_6:56470483-56470483 T>A_LPELTDSVKGKDDYFKNMTPKVDSS	0.0
14:90446909-90446909 G>A	1.0	4237	NSCLC	-	-	-	-	TDP1	ENST00000393454,p.E273K|uc010atn.3,p.E273K|ENST00000393452,p.E273K|uc001xxy.3,p.E273K|ENST00000557782,p.E21K|uc001xxz.3,p.E273K|ENST00000335725,p.E273K|ENST00000553617,p.E174K|NM_001008744,p.E273K|ENST00000555880,p.E273K|NM_018319,p.E273K|ENST00000545686,p.E273K	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010atn.3	nonsynonymous SNV	exon8	c.G817A	p.E273K	THHTKMMLLLYEEGLRVVIHTSNLI	THHTKMMLLLYEKGLRVVIHTSNLI	8.0	7.0	-	-	4237_14:90446909-90446909 G>A_THHTKMMLLLYEKGLRVVIHTSNLI	0.0
11:117314707-117314707 C>T	0.0	4213	COLORECTAL	-	-	-	-	DSCAML1	NM_020693,p.A1313T|uc001prh.1,p.A1313T|ENST00000321322,p.A1313T|ENST00000527706,p.A1043T	protein_coding	uc001prh.1	nonsynonymous SNV	exon21	c.G3937A	p.A1313T	YETSPEQLFYRIAHLNRGQQYLLWV	YETSPEQLFYRITHLNRGQQYLLWV	3.0	9.0	-	-	4213_11:117314707-117314707 C>T_YETSPEQLFYRITHLNRGQQYLLWV	0.0
7:44802526-44802526 C>T	1.0	4000	MELANOMA	-	-	-	-	ZMIZ2	uc003tls.3,p.S522L|ENST00000413916,p.S490L|uc003tlr.3,p.S548L|uc003tlq.3,p.S490L|NM_174929,p.S522L|ENST00000441627,p.S548L|NM_031449,p.S548L|NM_001300959,p.S490L|ENST00000433667,p.S516L|uc003tlt.3,p.S171L|uc010kyj.3,p.S70L|ENST00000309315,p.S548L|ENST00000265346,p.S522L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc010kyj.3	nonsynonymous SNV	exon3	c.C209T	p.S70L	FVLQLVHRPSVRSVLQGLLKKRLLP	FVLQLVHRPSVRLVLQGLLKKRLLP	9.0	8.0	-	-	4000_7:44802526-44802526 C>T_FVLQLVHRPSVRLVLQGLLKKRLLP	0.0
5:111506664-111506664 C>T	1.0	4326	BREAST	-	-	-	-	EPB41L4A	uc003kpv.1,p.E550K|NM_022140,p.E550K|uc003kpp.1,p.E177K|ENST00000261486,p.E550K	retained_intron, protein_coding, processed_transcript	uc003kpv.1	nonsynonymous SNV	exon19	c.G1648A	p.E550K	RSRSRSPDIQAKEELWKHIQKELVD	RSRSRSPDIQAKKELWKHIQKELVD	6.0	1.0	-	-	4326_5:111506664-111506664 C>T_RSRSRSPDIQAKKELWKHIQKELVD	0.0
5:140041904-140041904 C>T	1.0	3784	MELANOMA	-	-	-	-	IK	uc003lgq.3,p.P555L|ENST00000417647,p.P555L|NM_006083,p.P555L	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc003lgq.3	nonsynonymous SNV	exon20	c.C1664T	p.P555L	KKMEADGVEVKRPKY	KKMEADGVEVKRLKY	10.0	8.0	-	-	3784_5:140041904-140041904 C>T_KKMEADGVEVKRLKY	0.0
14:64488081-64488081 T>G	1.0	4345	COLORECTAL	-	-	-	-	SYNE2	ENST00000358025,p.L1734V|uc001xgm.3,p.L1734V|uc021ruh.1,p.L1734V|ENST00000554584,p.L1734V|uc001xgl.3,p.L1734V|ENST00000344113,p.L1734V|NM_015180,p.L1734V|NM_182914,p.L1734V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc021ruh.1	nonsynonymous SNV	exon35	c.T5200G	p.L1734V	SILNKMEHVQKCLTGESNCHALSGS	SILNKMEHVQKCVTGESNCHALSGS	10.0	6.0	-	-	4345_14:64488081-64488081 T>G_SILNKMEHVQKCVTGESNCHALSGS	0.0
6:28254865-28254865 C>T	1.0	4301	MELANOMA	-	-	-	-	PGBD1	NM_001184743,p.P188S|NM_032507,p.P188S|uc003nky.3,p.P188S|uc003nkz.3,p.P188S|ENST00000259883,p.P188S|ENST00000405948,p.P188S	protein_coding	uc003nkz.3	nonsynonymous SNV	exon4	c.C562T	p.P188S	PQGNPQEVSGPVPHGSAHLQEKNPR	PQGNPQEVSGPVSHGSAHLQEKNPR	6.0	3.0	-	-	4301_6:28254865-28254865 C>T_PQGNPQEVSGPVSHGSAHLQEKNPR	0.0
6:123539823-123539823 G>A	0.0	2591	MELANOMA	-	-	-	-	TRDN	ENST00000334268,p.P697S|uc010kem.2,p.P206S|ENST00000398178,p.P705S|NM_006073,p.P705S|uc003pzj.2,p.P705S	protein_coding	uc010kem.2	nonsynonymous SNV	exon28	c.C616T	p.P206S	YLDGYNGYGFQFPFTPADRPGESSG	YLDGYNGYGFQFSFTPADRPGESSG	1.0	7.0	-	-	2591_6:123539823-123539823 G>A_YLDGYNGYGFQFSFTPADRPGESSG	0.0
1:248512906-248512906 C>A	0.0	4259	COLORECTAL	-	-	-	-	OR14C36	ENST00000317861,p.S277Y|NM_001001918,p.S277Y|uc010pzl.2,p.S277Y	protein_coding	uc010pzl.2	nonsynonymous SNV	exon1	c.C830A	p.S277Y	AATQDLILSGFYSIMPPLFNPIIYS	AATQDLILSGFYYIMPPLFNPIIYS	1.0	8.0	-	-	4259_1:248512906-248512906 C>A_AATQDLILSGFYYIMPPLFNPIIYS	0.0
19:30020811-30020811 G>A	0.0	4326	BREAST	-	-	ID=COSM1392379;OCCURENCE=1(large_intestine)	-	VSTM2B	ENST00000335523,p.R128H|uc010xrl.1,p.R128H|NM_001146339,p.R128H	protein_coding	uc010xrl.1	nonsynonymous SNV	exon4	c.G383A	p.R128H	AVRLQDEGVYECRVSDYSDDDTQEH	AVRLQDEGVYECHVSDYSDDDTQEH	1.0	2.0	-	-	4326_19:30020811-30020811 G>A_AVRLQDEGVYECHVSDYSDDDTQEH	0.0
2:128935463-128935463 A>T	0.0	4134	NSCLC	-	-	-	-	UGGT1	uc002tpr.3,p.N1204Y|uc002tps.3,p.N1228Y|ENST00000259253,p.N1228Y|ENST00000375990,p.N1204Y|NM_020120,p.N1228Y	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002tps.3	nonsynonymous SNV	exon33	c.A3682T	p.N1228Y	VNEDLLSDGTSENESGFWDSFKWGF	VNEDLLSDGTSEYESGFWDSFKWGF	9.0	7.0	-	-	4134_2:128935463-128935463 A>T_VNEDLLSDGTSEYESGFWDSFKWGF	0.0
1:175046954-175046954 G>A	0.0	2591	MELANOMA	-	-	-	-	TNN	uc001gkl.1,p.G134R|uc010pmx.1,p.G134R|NM_022093,p.G134R|ENST00000239462,p.G134R	protein_coding	uc010pmx.1	nonsynonymous SNV	exon1	c.G400A	p.G134R	MKEQCSAQRCCQGVTDLSRHCSGHG	MKEQCSAQRCCQRVTDLSRHCSGHG	1.0	6.0	-	-	2591_1:175046954-175046954 G>A_MKEQCSAQRCCQRVTDLSRHCSGHG	0.0
2:48132726-48132740 GGCTGCTGCTGGGGC>-	1.0	4134	NSCLC	-	-	-	1	FBXO11	uc002rwg.2,p.40_45del|uc002rwe.3,p.40_45del|NM_001190274,p.40_45del|ENST00000403359,p.40_45del	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002rwg.2	nonframeshift deletion	exon1	c.120_134del	p.40_45del	PQQPPPQPPQQQPPQQQPPPPPQQQ	PQQPPPQPPQQQPPPPPQQQQQQQP	9.0	5.0	-	-	4134_2:48132726-48132740 GGCTGCTGCTGGGGC>-_PQQPPPQPPQQQPPPPPQQQQQQQP	0.0
6:30916626-30916626 G>A	0.0	4110	BILE DUCT	-	-	-	-	DPCR1	uc003nsg.2,p.G129R|NM_080870,p.G129R|ENST00000462446,p.G129R	protein_coding	uc003nsg.2	nonsynonymous SNV	exon2	c.G385A	p.G129R	APPTSEENSSNQGKDPMIRNQRSVD	APPTSEENSSNQRKDPMIRNQRSVD	3.0	8.0	-	-	4110_6:30916626-30916626 G>A_APPTSEENSSNQRKDPMIRNQRSVD	0.0
5:82833818-82833818 G>A	0.0	3775	CERVICAL	-	-	-	-	VCAN	uc003kii.3,p.D1666N|uc003kij.3,p.D679N|ENST00000513960,p.D679N|ENST00000343200,p.D679N|NM_004385,p.D1666N|NM_001164097,p.D679N|uc003kil.3,p.D330N|ENST00000265077,p.D1666N	retained_intron, protein_coding, processed_transcript	uc003kil.3	nonsynonymous SNV	exon1	c.G988A	p.D330N	TMVTDLSQRNTTDTLITLDTSRIIT	TMVTDLSQRNTTNTLITLDTSRIIT	10.0	6.0	-	-	3775_5:82833818-82833818 G>A_TMVTDLSQRNTTNTLITLDTSRIIT	0.0
10:50531479-50531479 G>A	0.0	4275	COLORECTAL	0.0005	-	-	-	C10orf71	ENST00000374144,p.V297I|ENST00000323868,p.V297I|NM_001135196,p.V297I|uc021pqa.2,p.V297I|uc021pqb.1,p.V297I	protein_coding, processed_transcript	uc021pqb.1	nonsynonymous SNV	exon1	c.G889A	p.V297I	PKLLERKDTAGTVPESKAPKHYGDT	PKLLERKDTAGTIPESKAPKHYGDT	1.0	5.0	-	-	4275_10:50531479-50531479 G>A_PKLLERKDTAGTIPESKAPKHYGDT	0.0
8:116616171-116616171 T>A	0.0	4346	COLORECTAL	-	-	-	-	TRPS1	ENST00000519674,p.E662D|uc011lhy.2,p.E666D|NM_001282902,p.E666D|ENST00000220888,p.E662D|ENST00000519076,p.E416D|ENST00000395715,p.E675D|NM_014112,p.E675D|uc003ynz.3,p.E662D|ENST00000517323,p.E466D|uc010mcy.3,p.E662D|uc003yny.3,p.E675D|ENST00000520276,p.E666D|NM_001282903,p.E668D	protein_coding, nonsense_mediated_decay	uc011lhy.2	nonsynonymous SNV	exon3	c.A1998T	p.E666D	HLQGSDGQQSVKESKEHSCTKCDFI	HLQGSDGQQSVKDSKEHSCTKCDFI	5.0	8.0	-	-	4346_8:116616171-116616171 T>A_HLQGSDGQQSVKDSKEHSCTKCDFI	0.0
16:29808333-29808333 C>T	1.0	3795	MELANOMA	-	-	-	-	KIF22	ENST00000570173,p.P64S|ENST00000160827,p.P64S|NM_007317,p.P64S|uc002dts.4,p.P64S	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dts.4	nonsynonymous SNV	exon2	c.C190T	p.P64S	PFVDGTAGASDPPCVRGMDSCSLEI	PFVDGTAGASDPSCVRGMDSCSLEI	9.0	5.0	-	-	3795_16:29808333-29808333 C>T_PFVDGTAGASDPSCVRGMDSCSLEI	0.0
16:30012148-30012148 C>T	1.0	4275	COLORECTAL	-	-	-	-	INO80E	ENST00000304516,p.A92V|ENST00000567254,p.A92V|ENST00000562441,p.A92V|ENST00000563197,p.A92V|ENST00000567065,p.A92V|uc002dvg.1,p.A92V|NM_173618,p.A92V|ENST00000567705,p.A92V|ENST00000567987,p.A92V	retained_intron, protein_coding, processed_transcript, nonsense_mediated_decay	uc002dvg.1	nonsynonymous SNV	exon4	c.C275T	p.A92V	ETEGTPKLSDTPAPKRKRSPPLGGA	ETEGTPKLSDTPVPKRKRSPPLGGA	10.0	2.0	-	-	4275_16:30012148-30012148 C>T_ETEGTPKLSDTPVPKRKRSPPLGGA	0.0
1:93300354-93300354 G>A	1.0	3903	MELANOMA	-	-	-	1	RPL5	NM_000969,p.E70K|ENST00000315741,p.E20K|uc001doz.3,p.E70K|ENST00000370321,p.E70K|uc001dpb.3,p.E20K	protein_coding, processed_transcript	uc001dpb.3	nonsynonymous SNV	exon2	c.G58A	p.E20K	RDIICQIAYARIEGDMIVCAAYAHE	RDIICQIAYARIKGDMIVCAAYAHE	10.0	5.0	-	-	3903_1:93300354-93300354 G>A_RDIICQIAYARIKGDMIVCAAYAHE	0.0
2:26950735-26950735 A>G	1.0	4237	NSCLC	-	-	-	-	KCNK3	uc002rhn.2,p.I162V|NM_002246,p.I162V|ENST00000302909,p.I162V	protein_coding	uc002rhn.2	nonsynonymous SNV	exon2	c.A484G	p.I162V	RRADVSMANMVLIGFFSCISTLCIG	RRADVSMANMVLVGFFSCISTLCIG	6.0	8.0	-	-	4237_2:26950735-26950735 A>G_RRADVSMANMVLVGFFSCISTLCIG	0.0